PedAM
Pediatric Disease Annotations & Medicines
| periodic limb movement disorder | ||||
| Disease ID | 1581 |
|---|---|
| Disease | periodic limb movement disorder |
| Definition | Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387) |
| Synonym | disorder limb movement periodic excessive periodic sleep relat leg movements excessive periodic sleep related leg movements excessive periodic sleep-related leg movements myoclonus syndrome, nocturnal myoclonus syndrome, sleep myoclonus syndromes, sleep nocturnal myoclonus syndrome nocturnal myoclonus syndrome [disease/finding] nocturnal myoclonus syndromes periodic leg movements excessive sleep relat periodic leg movements, excessive, sleep-related periodic limb movement periodic limb movement dis periodic limb movement disorder (disorder) periodic movement dis sleep periodic movement disorder, sleep sleep dis periodic movements sleep disorder, periodic movements sleep myoclonus syndrome sleep myoclonus syndromes sleep relat periodic leg movements excessive sleep related periodic leg movements, excessive sleep-related periodic leg movements, excessive syndrome, nocturnal myoclonus syndrome, sleep myoclonus syndromes, sleep myoclonus |
| DOID | |
| ICD10 | |
| UMLS | C0751774 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:6) C0002871 | anemia | 1 C0037315 | sleep apnea | 1 C0520679 | obstructive sleep apnea syndrome | 1 C0520679 | obstructive sleep apnea | 1 C0030567 | parkinson's disease | 1 C0037315 | sleep apnea syndrome | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:13) 57817 | HAMP | DISEASES 6532 | SLC6A4 | DISEASES 3358 | HTR2C | DISEASES 5187 | PER1 | DISEASES 3350 | HTR1A | DISEASES 5348 | FXYD1 | DISEASES 6935 | ZEB1 | DISEASES 56259 | CTNNBL1 | DISEASES 3356 | HTR2A | DISEASES 340152 | ZC3H12D | DISEASES 2741 | GLRA1 | DISEASES 102723508 | KANTR | DISEASES 114614 | MIR155HG | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1581 |
|---|---|
| Disease | periodic limb movement disorder |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:4) |
| Disease ID | 1581 |
|---|---|
| Disease | periodic limb movement disorder |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0751774 | olanzapine | C076029 | 132539-06-1 | nocturnal myoclonus syndrome | MESH:D020189 | marker/mechanism | 10505594 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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