PedAM

Pediatric Disease Annotations & Medicines


	pericarditis

Disease ID	904
Disease	pericarditis
Definition	Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.
Synonym	an inflammation of the membrane surrounding the heart pericarditis (disorder) pericarditis [disease/finding] pericarditis nos pericarditis, nos
DOID	DOID:1787
UMLS	C0031046
MeSH	D010493
SNOMED-CT	SNOMEDCT_US_2016_09_01:3238004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:89) C0007177 \| cardiac tamponade \| 35 C0031039 \| pericardial effusion \| 28 C0018801 \| heart failure \| 8 C0041296 \| tuberculosis \| 8 C0003873 \| rheumatoid arthritis \| 5 C0027059 \| myocarditis \| 5 C0014118 \| endocarditis \| 4 C0032285 \| pneumonia \| 4 C0006309 \| brucellosis \| 3 C0031048 \| constrictive pericarditis \| 3 C0085273 \| parvovirus b19 infection \| 2 C0019064 \| hemopericardium \| 2 C0027051 \| myocardial infarct \| 2 C0022661 \| chronic kidney disease \| 2 C0018802 \| congestive heart failure \| 2 C0409974 \| lupus erythematosus \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0027051 \| myocardial infarction \| 2 C0022658 \| renal disease \| 2 C0018799 \| heart disease \| 2 C0007177 \| pericardial tamponade \| 2 C0041948 \| uremia \| 2 C0031039 \| pericardial effusions \| 1 C0022408 \| arthropathy \| 1 C0878544 \| cardiomyopathy \| 1 C0014859 \| esophageal cancer \| 1 C0007115 \| thyroid cancer \| 1 C0242379 \| lung cancer \| 1 C1335381 \| pericardial mesothelioma \| 1 C0023895 \| hepatopathy \| 1 C0024299 \| malignant lymphoma \| 1 C0002726 \| amyloidosis \| 1 C0006142 \| breast cancer \| 1 C0027121 \| myositis \| 1 C0022658 \| kidney disease \| 1 C0035435 \| rheumatism \| 1 C0024115 \| pulmonary disease \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C1442837 \| myocardial necrosis \| 1 C0036205 \| pulmonary sarcoidosis \| 1 C0004943 \| behcet's disease \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0018213 \| graves' disease \| 1 C0025229 \| melioidosis \| 1 C0014121 \| infective endocarditis \| 1 C0272412 \| splenic abscess \| 1 C0023788 \| whipple's disease \| 1 C0003486 \| aortic aneurysm \| 1 C0025294 \| meningococcal meningitis \| 1 C0023364 \| leptospirosis \| 1 C0011570 \| depression \| 1 C0042214 \| vaccinia \| 1 C0021053 \| immune disease \| 1 C0024623 \| gastric cancer \| 1 C0022116 \| ischemia \| 1 C0007115 \| thyroid ca \| 1 C1135196 \| diastolic heart failure \| 1 C0343525 \| lemierre's syndrome \| 1 C0032453 \| relapsing polychondritis \| 1 C0022661 \| end stage renal disease \| 1 C0023448 \| lymphatic leukemia \| 1 C0041321 \| miliary tuberculosis \| 1 C1704437 \| respiratory distress syndrome \| 1 C0040053 \| thrombus \| 1 C0155686 \| acute myocarditis \| 1 C0025303 \| meningococcal disease \| 1 C0267572 \| ulcerative proctitis \| 1 C0025289 \| meningitis \| 1 C0033680 \| protein-losing enteropathy \| 1 C0023434 \| chronic lymphatic leukemia \| 1 C0003864 \| arthritis \| 1 C0039263 \| takayasu arteritis \| 1 C0014121 \| bacterial endocarditis \| 1 C0026934 \| mycoplasma \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0242966 \| systemic inflammatory response syndrome \| 1 C0007196 \| restrictive cardiomyopathy \| 1 C0026764 \| multiple myeloma \| 1 C0155862 \| pneumococcal pneumonia \| 1 C0175693 \| silver-russell syndrome \| 1 C0878675 \| erdheim-chester disease \| 1 C0033246 \| proctitis \| 1 C0035222 \| acute respiratory distress syndrome \| 1 C0080032 \| malignant effusion \| 1 C0031350 \| pharyngitis \| 1 C0022661 \| end-stage renal disease \| 1 C0032231 \| pleuritis \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0003509 \| aortitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PRG4 \| 10216 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:141) 1595 \| CYP51A1 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 4710 \| NDUFB4 \| DISEASES 9978 \| RBX1 \| DISEASES 79890 \| RIN3 \| DISEASES 4210 \| MEFV \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 9545 \| RAB3D \| DISEASES 7392 \| USF2 \| DISEASES 10282 \| BET1 \| DISEASES 10105 \| PPIF \| DISEASES 6783 \| SULT1E1 \| DISEASES 3458 \| IFNG \| DISEASES 3945 \| LDHB \| DISEASES 84830 \| ADTRP \| DISEASES 6908 \| TBP \| DISEASES 3336 \| HSPE1 \| DISEASES 5657 \| PRTN3 \| DISEASES 3764 \| KCNJ8 \| DISEASES 7291 \| TWIST1 \| DISEASES 6431 \| SRSF6 \| DISEASES 4277 \| MICB \| DISEASES 10343 \| PKDREJ \| DISEASES 1160 \| CKMT2 \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 23640 \| HSPBP1 \| DISEASES 59340 \| HRH4 \| DISEASES 3357 \| HTR2B \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 170679 \| PSORS1C1 \| DISEASES 6741 \| SSB \| DISEASES 4591 \| TRIM37 \| DISEASES 22858 \| ICK \| DISEASES 3553 \| IL1B \| DISEASES 735 \| C9 \| DISEASES 5443 \| POMC \| DISEASES 6897 \| TARS \| DISEASES 54806 \| AHI1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 5678 \| PSG9 \| DISEASES 5972 \| REN \| DISEASES 6567 \| SLC16A2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 3948 \| LDHC \| DISEASES 10225 \| CD96 \| DISEASES 7547 \| ZIC3 \| DISEASES 1636 \| ACE \| DISEASES 89858 \| SIGLEC12 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 79885 \| HDAC11 \| DISEASES 213 \| ALB \| DISEASES 7047 \| TGM4 \| DISEASES 1437 \| CSF2 \| DISEASES 1152 \| CKB \| DISEASES 55800 \| SCN3B \| DISEASES 1159 \| CKMT1B \| DISEASES 64127 \| NOD2 \| DISEASES 5734 \| PTGER4 \| DISEASES 134526 \| ACOT12 \| DISEASES 118429 \| ANTXR2 \| DISEASES 56246 \| MRAP \| DISEASES 160065 \| PATE1 \| DISEASES 5340 \| PLG \| DISEASES 171389 \| NLRP6 \| DISEASES 5771 \| PTPN2 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 64388 \| GREM2 \| DISEASES 783 \| CACNB2 \| DISEASES 9920 \| KBTBD11 \| DISEASES 1153 \| CIRBP \| DISEASES 7706 \| TRIM25 \| DISEASES 5366 \| PMAIP1 \| DISEASES 79969 \| ATAT1 \| DISEASES 9798 \| IST1 \| DISEASES 338321 \| NLRP9 \| DISEASES 3043 \| HBB \| DISEASES 81608 \| FIP1L1 \| DISEASES 114548 \| NLRP3 \| DISEASES 123283 \| TARSL2 \| DISEASES 23583 \| SMUG1 \| DISEASES 5313 \| PKLR \| DISEASES 117178 \| SSX2IP \| DISEASES 123228 \| SENP8 \| DISEASES 4089 \| SMAD4 \| DISEASES 7137 \| TNNI3 \| DISEASES 22953 \| P2RX2 \| DISEASES 23481 \| PES1 \| DISEASES 50488 \| MINK1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 781 \| CACNA2D1 \| DISEASES 135250 \| RAET1E \| DISEASES 6775 \| STAT4 \| DISEASES 4151 \| MB \| DISEASES 6905 \| TBCE \| DISEASES 10765 \| KDM5B \| DISEASES 7139 \| TNNT2 \| DISEASES 6738 \| TROVE2 \| DISEASES 10758 \| TRAF3IP2 \| DISEASES 7390 \| UROS \| DISEASES 80222 \| TARS2 \| DISEASES 8036 \| SHOC2 \| DISEASES 1810 \| DR1 \| DISEASES 959 \| CD40LG \| DISEASES 100 \| ADA \| DISEASES 129685 \| TAF8 \| DISEASES 27095 \| TRAPPC3 \| DISEASES 3339 \| HSPG2 \| DISEASES 3055 \| HCK \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 4879 \| NPPB \| DISEASES 116085 \| SLC22A12 \| DISEASES 1804 \| DPP6 \| DISEASES 79625 \| NDNF \| DISEASES 10457 \| GPNMB \| DISEASES 8887 \| TAX1BP1 \| DISEASES 51147 \| ING4 \| DISEASES 11069 \| RAPGEF4 \| DISEASES 51128 \| SAR1B \| DISEASES 51135 \| IRAK4 \| DISEASES 7124 \| TNF \| DISEASES 10216 \| PRG4 \| DISEASES 3594 \| IL12RB1 \| DISEASES 548596 \| CKMT1A \| DISEASES 55655 \| NLRP2 \| DISEASES 283337 \| ZNF740 \| DISEASES 204801 \| NLRP11 \| DISEASES 83871 \| RAB34 \| DISEASES 345611 \| IRGM \| DISEASES 3939 \| LDHA \| DISEASES 56963 \| RGMA \| DISEASES 85316 \| BAGE5 \| DISEASES 6625 \| SNRNP70 \| DISEASES 10866 \| HCP5 \| DISEASES 102723508 \| KANTR \| DISEASES 103752588 \| PACERR \| DISEASES 26799 \| SNORD50A \| DISEASES
Locus	(Waiting for update.)

Disease ID	904
Disease	pericarditis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:61) HP:0001698 \| Pericardial effusions \| 27 HP:0001635 \| Congestive heart failure \| 8 HP:0100749 \| Thoracic pain \| 8 HP:0012531 \| Pain \| 7 HP:0001370 \| Rheumatoid arthritis \| 5 HP:0012819 \| Myocarditis \| 5 HP:0001541 \| Ascites \| 4 HP:0100584 \| Endocarditis \| 3 HP:0030149 \| Cardiovascular shock \| 3 HP:0002563 \| Constrictive pericarditis \| 3 HP:0011851 \| Hemopericardium \| 2 HP:0010310 \| Chylothorax \| 2 HP:0002202 \| Pleural effusion \| 2 HP:0006689 \| Bacterial endocarditis \| 2 HP:0002090 \| Pneumonia \| 2 HP:0006532 \| Pneumonia, recurrent episodes \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0002094 \| Dyspnea \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0012281 \| Chylous ascites \| 2 HP:0001631 \| Atria septal defect \| 1 HP:0001287 \| Meningitis \| 1 HP:0001945 \| Fever \| 1 HP:0004942 \| Aortic aneurysm \| 1 HP:0000716 \| Depression \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0001609 \| Hoarseness \| 1 HP:0030834 \| Shoulder pain \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0002240 \| Enlarged liver \| 1 HP:0001723 \| Restrictive cardiomyopathy \| 1 HP:0002243 \| Protein-losing enteropathy \| 1 HP:0010783 \| Erythema \| 1 HP:0100721 \| Mediastinal lymphadenopathy \| 1 HP:0003040 \| Arthropathy \| 1 HP:0012735 \| Coughing \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0045073 \| Serositis \| 1 HP:0002102 \| Pleuritis \| 1 HP:0001649 \| Tachycardia \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0002631 \| Ascending aortic aneurysm \| 1 HP:0000969 \| Dropsy \| 1 HP:0001369 \| Arthritis \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0001681 \| Angina pectoris \| 1 HP:0001708 \| Impaired right ventricular function \| 1 HP:0001700 \| Myocardial necrosis \| 1 HP:0001041 \| Blushing \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0100004 \| Pericardial mesothelioma \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002664 \| Neoplasia \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100614 \| Muscle inflammation \| 1

Disease ID	904
Disease	pericarditis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0007177 \| cardiac tamponade \| 34 C0031039 \| pericardial effusion \| 26 C0018801 \| heart failure \| 8 C0008031 \| chest pain \| 8 C0031039 \| pericardial effusions \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs3099844	25369137	6775	STAT4	umls:C0031046	BeFree	The genotype/phenotype correlation analysis showed several associations including a higher risk to develop pericarditis with STAT4, and an association between HCP5 rs3099844 and anti-Ro/SSA antibodies.	0.000271442	2014	LOC102725068	6	31481199	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:15)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0031046	amikacin	D000583	37517-28-5	pericarditis	MESH:D010493	therapeutic	20622739
C0031046	amphetamine	D000661	300-62-9	pericarditis	MESH:D010493	marker/mechanism	9889603
C0031046	cabergoline	C047047	81409-90-7	pericarditis	MESH:D010493	marker/mechanism	19170199
C0031046	cefotaxime	D002439	63527-52-6	pericarditis	MESH:D010493	marker/mechanism	2041948
C0031046	clozapine	D003024	5786-21-0	pericarditis	MESH:D010493	marker/mechanism	11870026
C0031046	cyclophosphamide	D003520	50-18-0	pericarditis	MESH:D010493	marker/mechanism	11041571
C0031046	fluorouracil	D005472	51-21-8	pericarditis	MESH:D010493	marker/mechanism	2205312
C0031046	indomethacin	D007213	53-86-1	pericarditis	MESH:D010493	therapeutic	7752506
C0031046	methotrexate	D008727	1959/5/2	pericarditis	MESH:D010493	marker/mechanism	17520171
C0031046	methylphenidate	D008774	113-45-1	pericarditis	MESH:D010493	marker/mechanism	19296063
C0031046	minoxidil	D008914	38304-91-5	pericarditis	MESH:D010493	marker/mechanism	4053985
C0031046	propylthiouracil	D011441	51-52-5	pericarditis	MESH:D010493	marker/mechanism	11250767
C0031046	tramadol	D014147	27203-92-5	pericarditis	MESH:D010493	marker/mechanism	15771942
C0031046	valproic acid	D014635	99-66-1	pericarditis	MESH:D010493	marker/mechanism	11244813
C0031046	vancomycin	D014640	1404-90-6	pericarditis	MESH:D010493	therapeutic	1835557

FDA approved drug and dosage information(Total Drugs:3)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D010493	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D010493	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D010493	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No

FDA labeling changes(Total Drugs:3)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D010493	6/4/2006	daytrana	methylphenidate	ADHD	Summary is pending	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D010493	12/14/2009	daytrana	methylphenidate	Postmarketing safety study	Information added to Warnings and Adverse Reactions on skin reactions observed in a postmarketing dermal study in pediatric patients	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D010493	06/29/2010	daytrana	methylphenidate	ADHD	Expanded pediatric indication to include adolescent patients ages13-17 years The most commonly reported adverse reactions in a trial in patients 13-17 years included appetite decreased, nausea, insomnia, weight decreased, dizziness, abdominal pain, and anorexia. The majority of patients had erythema at the application site Information on PK parameters, Adverse Event profile and clinical studies	Labeling	-	P	-	-	Shire	-	FALSE'

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