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Pediatric Disease Annotations & Medicines



   pericardial effusion
  

Disease ID 897
Disease pericardial effusion
Definition
Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
Synonym
effusion pericardial
effusion, pericardial
effusions, pericardial
fluid, pericardial
pericardial effusion (disorder)
pericardial effusion [disease/finding]
pericardial effusion, nos
pericardial effusions
pericardial fluid
DOID
UMLS
C0031039
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:115)
C0007177  |  cardiac tamponade  |  58
C0031046  |  pericarditis  |  25
C0018801  |  heart failure  |  11
C0020676  |  hypothyroidism  |  11
C0242379  |  lung cancer  |  6
C1619734  |  pulmonary arterial hypertension  |  5
C0041296  |  tuberculosis  |  5
C0020538  |  hypertension  |  4
C0031048  |  constrictive pericarditis  |  4
C0020542  |  pulmonary hypertension  |  3
C0014859  |  esophageal cancer  |  3
C0024299  |  lymphoma  |  3
C0035078  |  renal failure  |  3
C0039483  |  giant cell arteritis  |  2
C0040100  |  thymoma  |  2
C0878675  |  erdheim-chester disease  |  2
C0026266  |  mitral regurgitation  |  2
C0020224  |  polyhydramnios  |  2
C1140680  |  ovarian ca  |  2
C0022658  |  renal disease  |  2
C0018916  |  hemangioma  |  2
C0027051  |  myocardial infarction  |  2
C0079731  |  b-cell lymphoma  |  2
C0027051  |  myocardial infarct  |  2
C0024141  |  systemic lupus erythematosus  |  2
C0022660  |  acute renal failure  |  2
C0025229  |  melioidosis  |  2
C0007177  |  pericardial tamponade  |  2
C0036421  |  systemic sclerosis  |  2
C0027059  |  myocarditis  |  2
C0032533  |  polymyalgia rheumatica  |  2
C0018916  |  haemangioma  |  2
C0020676  |  hypothyroid  |  2
C0023473  |  chronic myeloid leukemia  |  2
C0003873  |  rheumatoid arthritis  |  2
C0032285  |  pneumonia  |  2
C0018801  |  cardiac failure  |  1
C0010051  |  coronary artery aneurysm  |  1
C0006142  |  breast cancer  |  1
C1140680  |  ovarian cancer  |  1
C0009171  |  cocaine abuse  |  1
C0235974  |  pancreatic cancer  |  1
C0022661  |  chronic renal failure  |  1
C0032319  |  pneumopericardium  |  1
C0017205  |  gaucher's disease  |  1
C0278689  |  recurrent ovarian cancer  |  1
C0409974  |  lupus erythematosus  |  1
C0264716  |  chronic heart failure  |  1
C0042769  |  virus infection  |  1
C0003509  |  aortitis  |  1
C1145670  |  respiratory failure  |  1
C0014118  |  endocarditis  |  1
C0026266  |  mitral valve insufficiency  |  1
C0041321  |  miliary tuberculosis  |  1
C0014121  |  infective endocarditis  |  1
C0600260  |  obstructive pulmonary disease  |  1
C0031117  |  peripheral neuropathy  |  1
C0040053  |  thrombus  |  1
C0205969  |  thymic carcinoma  |  1
C0022661  |  chronic kidney disease  |  1
C0022116  |  ischemia  |  1
C0024623  |  gastric cancer  |  1
C0745140  |  hyperthyroid  |  1
C0018799  |  cardiac disease  |  1
C0032357  |  poland syndrome  |  1
C0751552  |  thymic cancer  |  1
C0034065  |  pulmonary embolism  |  1
C0023418  |  leukemia  |  1
C0001418  |  adenocarcinoma  |  1
C0007112  |  prostate adenocarcinoma  |  1
C0006271  |  bronchiolitis  |  1
C0013990  |  emphysema  |  1
C0024299  |  lymphomas  |  1
C0010051  |  coronary artery aneurysms  |  1
C0162309  |  x-linked adrenoleukodystrophy  |  1
C0023449  |  acute lymphoblastic leukaemia  |  1
C0040553  |  toxocariasis  |  1
C0151744  |  myocardial ischemia  |  1
C0016085  |  filariasis  |  1
C0023452  |  childhood acute lymphoblastic leukemia  |  1
C0040147  |  thyroiditis  |  1
C0003486  |  aortic aneurysm  |  1
C0162309  |  adrenoleukodystrophy  |  1
C0149925  |  small cell lung cancer  |  1
C0001339  |  acute pancreatitis  |  1
C0006267  |  bronchiectasis  |  1
C0024117  |  chronic obstructive pulmonary disease  |  1
C0079744  |  diffuse large b-cell lymphoma  |  1
C0042384  |  vasculitis  |  1
C0022661  |  end-stage renal disease  |  1
C0014733  |  erysipelas  |  1
C0040961  |  tricuspid regurgitation  |  1
C0030421  |  paraganglioma  |  1
C0007570  |  celiac disease  |  1
C0013502  |  hydatid cyst  |  1
C0022658  |  kidney disease  |  1
C0018920  |  cavernous hemangioma  |  1
C0011644  |  scleroderma  |  1
C0032805  |  postpericardiotomy syndrome  |  1
C0029927  |  ovarian cyst  |  1
C0030305  |  pancreatitis  |  1
C0153500  |  heart ca  |  1
C0029925  |  ovarian carcinoma  |  1
C0024115  |  pulmonary disease  |  1
C0020550  |  hyperthyroidism  |  1
C0006309  |  brucellosis  |  1
C0795690  |  omphalocele  |  1
C0021400  |  influenza  |  1
C0677607  |  hashimoto thyroiditis  |  1
C0442874  |  neuropathy  |  1
C0004153  |  atherosclerosis  |  1
C0024141  |  lupus syndrome  |  1
C0019829  |  hodgkin's lymphoma  |  1
C0546837  |  oesophageal cancer  |  1
C0020305  |  hydrops fetalis  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:2)
PLAT  |  5327  |  CTD_human
PTGS2  |  5743  |  CTD_human
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:191)
84957  |  RELT  |  DISEASES
9567  |  GTPBP1  |  DISEASES
79890  |  RIN3  |  DISEASES
5753  |  PTK6  |  DISEASES
140679  |  SLC32A1  |  DISEASES
2158  |  F9  |  DISEASES
4210  |  MEFV  |  DISEASES
7038  |  TG  |  DISEASES
5327  |  PLAT  |  DISEASES
973  |  CD79A  |  DISEASES
1048  |  CEACAM5  |  DISEASES
7392  |  USF2  |  DISEASES
2077  |  ERF  |  DISEASES
4353  |  MPO  |  DISEASES
1440  |  CSF3  |  DISEASES
952  |  CD38  |  DISEASES
3558  |  IL2  |  DISEASES
2026  |  ENO2  |  DISEASES
6534  |  SLC6A7  |  DISEASES
604  |  BCL6  |  DISEASES
7276  |  TTR  |  DISEASES
3070  |  HELLS  |  DISEASES
3764  |  KCNJ8  |  DISEASES
654231  |  OCM  |  DISEASES
28981  |  IFT81  |  DISEASES
10888  |  GPR83  |  DISEASES
5911  |  RAP2A  |  DISEASES
968  |  CD68  |  DISEASES
3270  |  HRC  |  DISEASES
6382  |  SDC1  |  DISEASES
6737  |  TRIM21  |  DISEASES
23647  |  ARFIP2  |  DISEASES
6117  |  RPA1  |  DISEASES
1401  |  CRP  |  DISEASES
4951  |  OCM2  |  DISEASES
3569  |  IL6  |  DISEASES
3557  |  IL1RN  |  DISEASES
6741  |  SSB  |  DISEASES
10060  |  ABCC9  |  DISEASES
945  |  CD33  |  DISEASES
6521  |  SLC4A1  |  DISEASES
1770  |  DNAH9  |  DISEASES
8178  |  ELL  |  DISEASES
25939  |  SAMHD1  |  DISEASES
22858  |  ICK  |  DISEASES
7299  |  TYR  |  DISEASES
9424  |  KCNK6  |  DISEASES
8647  |  ABCB11  |  DISEASES
943  |  TNFRSF8  |  DISEASES
6897  |  TARS  |  DISEASES
5286  |  PIK3C2A  |  DISEASES
5373  |  PMM2  |  DISEASES
2064  |  ERBB2  |  DISEASES
56006  |  SMG9  |  DISEASES
57410  |  SCYL1  |  DISEASES
5972  |  REN  |  DISEASES
6567  |  SLC16A2  |  DISEASES
4851  |  NOTCH1  |  DISEASES
2180  |  ACSL1  |  DISEASES
10225  |  CD96  |  DISEASES
7547  |  ZIC3  |  DISEASES
6750  |  SST  |  DISEASES
56683  |  C21orf59  |  DISEASES
1636  |  ACE  |  DISEASES
10158  |  PDZK1IP1  |  DISEASES
213  |  ALB  |  DISEASES
5885  |  RAD21  |  DISEASES
90390  |  MED30  |  DISEASES
79053  |  ALG8  |  DISEASES
4775  |  NFATC3  |  DISEASES
6249  |  CLIP1  |  DISEASES
118429  |  ANTXR2  |  DISEASES
23627  |  PRND  |  DISEASES
5002  |  SLC22A18  |  DISEASES
2147  |  F2  |  DISEASES
5340  |  PLG  |  DISEASES
171389  |  NLRP6  |  DISEASES
947  |  CD34  |  DISEASES
56945  |  MRPS22  |  DISEASES
51172  |  NAGPA  |  DISEASES
6208  |  RPS14  |  DISEASES
1240  |  CMKLR1  |  DISEASES
924  |  CD7  |  DISEASES
8557  |  TCAP  |  DISEASES
1776  |  DNASE1L3  |  DISEASES
28959  |  TMEM176B  |  DISEASES
137814  |  NKX2-6  |  DISEASES
147179  |  WIPF2  |  DISEASES
25970  |  SH2B1  |  DISEASES
9920  |  KBTBD11  |  DISEASES
3039  |  HBA1  |  DISEASES
1153  |  CIRBP  |  DISEASES
7706  |  TRIM25  |  DISEASES
3032  |  HADHB  |  DISEASES
55748  |  CNDP2  |  DISEASES
3052  |  HCCS  |  DISEASES
161882  |  ZFPM1  |  DISEASES
10052  |  GJC1  |  DISEASES
3043  |  HBB  |  DISEASES
2152  |  F3  |  DISEASES
10732  |  TCFL5  |  DISEASES
81608  |  FIP1L1  |  DISEASES
60528  |  ELAC2  |  DISEASES
123283  |  TARSL2  |  DISEASES
23583  |  SMUG1  |  DISEASES
857  |  CAV1  |  DISEASES
7137  |  TNNI3  |  DISEASES
132884  |  EVC2  |  DISEASES
921  |  CD5  |  DISEASES
5449  |  POU1F1  |  DISEASES
149998  |  LIPI  |  DISEASES
3767  |  KCNJ11  |  DISEASES
23481  |  PES1  |  DISEASES
6651  |  SON  |  DISEASES
37  |  ACADVL  |  DISEASES
1635  |  DCTD  |  DISEASES
135250  |  RAET1E  |  DISEASES
5079  |  PAX5  |  DISEASES
1969  |  EPHA2  |  DISEASES
2013  |  EMP2  |  DISEASES
2157  |  F8  |  DISEASES
4311  |  MME  |  DISEASES
10367  |  MICU1  |  DISEASES
6905  |  TBCE  |  DISEASES
28514  |  DLL1  |  DISEASES
5362  |  PLXNA2  |  DISEASES
7139  |  TNNT2  |  DISEASES
5788  |  PTPRC  |  DISEASES
462  |  SERPINC1  |  DISEASES
2117  |  ETV3  |  DISEASES
80222  |  TARS2  |  DISEASES
8036  |  SHOC2  |  DISEASES
914  |  CD2  |  DISEASES
959  |  CD40LG  |  DISEASES
81030  |  ZBP1  |  DISEASES
7422  |  VEGFA  |  DISEASES
9670  |  IPO13  |  DISEASES
100  |  ADA  |  DISEASES
1759  |  DNM1  |  DISEASES
129685  |  TAF8  |  DISEASES
27095  |  TRAPPC3  |  DISEASES
80312  |  TET1  |  DISEASES
84890  |  ADO  |  DISEASES
1269  |  CNR2  |  DISEASES
27301  |  APEX2  |  DISEASES
11240  |  PADI2  |  DISEASES
2155  |  F7  |  DISEASES
3055  |  HCK  |  DISEASES
8449  |  DHX16  |  DISEASES
4879  |  NPPB  |  DISEASES
4878  |  NPPA  |  DISEASES
2623  |  GATA1  |  DISEASES
5251  |  PHEX  |  DISEASES
9247  |  GCM2  |  DISEASES
22944  |  KIN  |  DISEASES
551  |  AVP  |  DISEASES
2315  |  MLANA  |  DISEASES
399  |  RHOH  |  DISEASES
94  |  ACVRL1  |  DISEASES
238  |  ALK  |  DISEASES
163126  |  EID2  |  DISEASES
3122  |  HLA-DRA  |  DISEASES
174  |  AFP  |  DISEASES
3652  |  IPP  |  DISEASES
4689  |  NCF4  |  DISEASES
23365  |  ARHGEF12  |  DISEASES
7110  |  TMF1  |  DISEASES
54826  |  GIN1  |  DISEASES
23414  |  ZFPM2  |  DISEASES
7018  |  TF  |  DISEASES
10989  |  IMMT  |  DISEASES
11137  |  PWP1  |  DISEASES
4776  |  NFATC4  |  DISEASES
7124  |  TNF  |  DISEASES
10216  |  PRG4  |  DISEASES
5817  |  PVR  |  DISEASES
9278  |  ZBTB22  |  DISEASES
54900  |  LAX1  |  DISEASES
2876  |  GPX1  |  DISEASES
83871  |  RAB34  |  DISEASES
6760  |  SS18  |  DISEASES
5447  |  POR  |  DISEASES
930  |  CD19  |  DISEASES
51271  |  UBAP1  |  DISEASES
83857  |  TMTC1  |  DISEASES
6625  |  SNRNP70  |  DISEASES
100316868  |  HOTTIP  |  DISEASES
102723508  |  KANTR  |  DISEASES
4573  |  MT-TR  |  DISEASES
103752588  |  PACERR  |  DISEASES
6082  |  SNORD20  |  DISEASES
Locus(Waiting for update.)
Disease ID 897
Disease pericardial effusion
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:113)
HP:0001701  |  Pericarditis  |  24
HP:0001635  |  Congestive heart failure  |  12
HP:0000821  |  Underactive thyroid  |  11
HP:0002202  |  Pleural effusion  |  9
HP:0005110  |  Atrial fibrillation  |  4
HP:0002563  |  Constrictive pericarditis  |  4
HP:0002665  |  Lymphoma  |  3
HP:0000822  |  Hypertension  |  3
HP:0002664  |  Neoplasia  |  3
HP:0000083  |  Renal insufficiency  |  3
HP:0001640  |  Increased heart size  |  3
HP:0012531  |  Pain  |  3
HP:0001653  |  Mitral valve insufficiency  |  3
HP:0002375  |  Decreased spontaneous movement  |  3
HP:0002094  |  Dyspnea  |  3
HP:0100749  |  Thoracic pain  |  3
HP:0030731  |  Carcinoma  |  2
HP:0005506  |  Chronic myeloid leukemia  |  2
HP:0100522  |  Thymoma  |  2
HP:0002090  |  Pneumonia  |  2
HP:0001370  |  Rheumatoid arthritis  |  2
HP:0001945  |  Fever  |  2
HP:0002725  |  Systemic lupus erythematosus  |  2
HP:0001658  |  Myocardial infarction  |  2
HP:0012191  |  B-cell lymphoma  |  2
HP:0002092  |  Pulmonary artery hypertension  |  2
HP:0012819  |  Myocarditis  |  2
HP:0012089  |  Arteritis  |  2
HP:0002902  |  Hyponatremia  |  2
HP:0200058  |  Angiosarcoma  |  2
HP:0003774  |  End-stage renal failure  |  2
HP:0030718  |  Right atrial enlargement  |  2
HP:0030149  |  Cardiovascular shock  |  2
HP:0001028  |  Strawberry mark  |  2
HP:0001541  |  Ascites  |  2
HP:0100571  |  Cardiac diverticulum  |  2
HP:0001919  |  Acute renal failure  |  2
HP:0001880  |  Eosinophilia  |  2
HP:0001561  |  Hydramnios  |  2
HP:0000969  |  Dropsy  |  2
HP:0007430  |  Generalized edema  |  2
HP:0001714  |  Ventricular hypertrophy  |  1
HP:0006510  |  Chronic obstructive pulmonary disease  |  1
HP:0002647  |  Aortic dissection  |  1
HP:0000872  |  Hashimoto's thyroiditis  |  1
HP:0002621  |  Atherosclerosis  |  1
HP:0100584  |  Endocarditis  |  1
HP:0012886  |  Hemorrhagic ovarian cyst  |  1
HP:0001789  |  Hydrops fetalis  |  1
HP:0100750  |  Pulmonary atelectasis  |  1
HP:0001297  |  Cerebral vascular events  |  1
HP:0100730  |  Bronchogenic cyst  |  1
HP:0000832  |  Primary hypothyroidism  |  1
HP:0012281  |  Chylous ascites  |  1
HP:0006689  |  Bacterial endocarditis  |  1
HP:0012735  |  Coughing  |  1
HP:0000790  |  Hematuria  |  1
HP:0003073  |  Hypoalbuminaemia  |  1
HP:0002880  |  Respiratory difficulties  |  1
HP:0002110  |  Bronchiectasis  |  1
HP:0002955  |  Granulomatosis  |  1
HP:0002015  |  Swallowing difficulty  |  1
HP:0002204  |  Pulmonary embolism  |  1
HP:0100646  |  Thyroiditis  |  1
HP:0002304  |  Akinesia  |  1
HP:0005306  |  Capillary hemangioma  |  1
HP:0003002  |  Breast carcinoma  |  1
HP:0002894  |  Neoplasia of the pancreas  |  1
HP:0001733  |  Pancreatic inflammation  |  1
HP:0001744  |  Splenomegaly  |  1
HP:0011950  |  Bronchiolitis  |  1
HP:0012050  |  Anasarca  |  1
HP:0030357  |  Small cell lung carcinoma  |  1
HP:0002097  |  Pulmonary emphysema  |  1
HP:0002615  |  Low blood pressure  |  1
HP:0001279  |  Syncope  |  1
HP:0000836  |  Overactive thyroid  |  1
HP:0005180  |  Tricuspid insufficiency  |  1
HP:0045073  |  Serositis  |  1
HP:0002716  |  Lymph node hyperplasia  |  1
HP:0012587  |  Gross hematuria  |  1
HP:0002960  |  Autoimmune condition  |  1
HP:0001259  |  Coma  |  1
HP:0001909  |  Leukemia  |  1
HP:0001961  |  Hypoplastic heart  |  1
HP:0001631  |  Atria septal defect  |  1
HP:0001539  |  Omphalocele  |  1
HP:0002633  |  Vasculitis  |  1
HP:0002098  |  Respiratory distress  |  1
HP:0100324  |  Progressive systemic scleroderma  |  1
HP:0004942  |  Aortic aneurysm  |  1
HP:0000282  |  Facial puffiness  |  1
HP:0002617  |  Aneurysmal dilatation  |  1
HP:0001735  |  Acute pancreatitis  |  1
HP:0012189  |  Hodgkin disease  |  1
HP:0004933  |  Ascending aortic dissection  |  1
HP:0001433  |  Enlarged liver and spleen  |  1
HP:0011675  |  Arrhythmias  |  1
HP:0005132  |  Pericardial constriction  |  1
HP:0001662  |  Bradycardia  |  1
HP:0009830  |  Peripheral neuritis  |  1
HP:0002878  |  Respiratory failure  |  1
HP:0002608  |  Celiac disease  |  1
HP:0002089  |  Hypoplastic lungs  |  1
HP:0012622  |  Chronic kidney disease  |  1
HP:0001048  |  Cavernous angioma  |  1
HP:0012764  |  Orthopnea  |  1
HP:0100827  |  Lymphocytosis  |  1
HP:0001055  |  Erysipelas  |  1
HP:0002240  |  Enlarged liver  |  1
HP:0000138  |  Ovarian cyst  |  1
HP:0002668  |  Paragangliomas  |  1
HP:0100790  |  Hernia  |  1
Disease ID 897
Disease pericardial effusion
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:9)
C0007177  |  cardiac tamponade  |  56
C0018801  |  heart failure  |  11
C0031048  |  constrictive pericarditis  |  4
C0035078  |  renal failure  |  3
C0018800  |  cardiomegaly  |  3
C0264714  |  acute heart failure  |  3
C0012817  |  diverticulum  |  2
C0020542  |  pulmonary hypertension  |  2
C0020649  |  hypotension  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:4)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs37648802444578051311TLR8umls:C0031039BeFreeTLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females.0.0002714422013TLR8;TLR8-AS1X12906707AG
rs37648802444578051284TLR7umls:C0031039BeFreeTLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females.0.0002714422013TLR8;TLR8-AS1X12906707AG
rs38538392444578051284TLR7umls:C0031039BeFreeTLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females.0.0002714422013TLR7X12889539CG
rs38538392444578051311TLR8umls:C0031039BeFreeTLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females.0.0002714422013TLR7X12889539CG
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:16)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0031039arsenic trioxideC0066321327-53-3pericardial effusionMESH:D010490marker/mechanism12669407
C0031039busulfanD00206655-98-1pericardial effusionMESH:D010490marker/mechanism4691200
C0031039carbamazepineD002220298-46-4pericardial effusionMESH:D010490marker/mechanism16283138
C0031039carmustineD002330154-93-8pericardial effusionMESH:D010490marker/mechanism18344943
C0031039chlorthalidoneD00275277-36-1pericardial effusionMESH:D010490marker/mechanism3836295
C0031039clozapineD0030245786-21-0pericardial effusionMESH:D010490marker/mechanism11870026
C0031039cyclophosphamideD00352050-18-0pericardial effusionMESH:D010490marker/mechanism25023062
C0031039gemcitabineC056507103882-84-4pericardial effusionMESH:D010490marker/mechanism16109609
C0031039indomethacinD00721353-86-1pericardial effusionMESH:D010490marker/mechanism1923225
C0031039labetalolD00774136894-69-6pericardial effusionMESH:D010490marker/mechanism9828745
C0031039methotrexateD0087271959/5/2pericardial effusionMESH:D010490marker/mechanism10576662
C0031039methysergideD008784361-37-5pericardial effusionMESH:D010490marker/mechanism15151680
C0031039minoxidilD00891438304-91-5pericardial effusionMESH:D010490marker/mechanism12356348
C0031039thalidomideD01379250-35-1pericardial effusionMESH:D010490marker/mechanism11972510
C0031039tretinoinD014212302-79-4pericardial effusionMESH:D010490marker/mechanism1637024
C0031039valproic acidD01463599-66-1pericardial effusionMESH:D010490marker/mechanism15901671
FDA approved drug and dosage information(Total Drugs:1)
DiseaseID Drug_name active_ingredients strength Dosage Form/Route Marketing Status TE code RLD RS
MESH:D010490busulfexbusulfan6MG/MLINJECTABLE;INJECTIONPrescriptionAPYesYes
FDA labeling changes(Total Drugs:1)
DiseaseID Pediatric_Labeling_Date Trade_Name Generic_Name_or_Proper_Name Indications Studied Label Changes Summary Product Labeling BPCA(B) PREA(P) BPCA(B) and PREA(P) Pediatric Rule (R) Sponsor Pediatric Exclusivity Granted Date NNPS
MESH:D01049001/13/2003busulfexbusulfanPart of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseasesThe population pharmacokinetic estimates of busulfan for clearance and volume of distribution were determined in an open-label, uncontrolled PK study in 24 pediatric patients 5 months to 16 years who received busulfan as part of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseases Suggested dosing regimenLabelingB---Orphan Medical12/3/2002FALSE'