PedAM

Pediatric Disease Annotations & Medicines


	peptic ulcer disease

Disease ID	828
Disease	peptic ulcer disease
Definition	Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Synonym	site unspecified gastroduodenal ulcer gastroduodenal ulcer, nos gastroduodenal ulcers peptic ulcer peptic ulcer (disorder) peptic ulcer - (pu) site unspecified peptic ulcer - (pu) site unspecified (disorder) peptic ulcer [disease/finding] peptic ulcer disorder peptic ulcer nos peptic ulcer nos (disorder) peptic ulcer nos = pu peptic ulcer syndrome peptic ulcer, nos peptic ulcer, site unspecified peptic ulceration peptic ulcers pu - peptic ulcer pud - peptic ulcer disease syndrome peptic ulcer ulcer gastroduodenal ulcer of the gastrointestinal tract ulcer peptic ulcer syndrome peptic ulcer, gastroduodenal ulcer, peptic ulcers, gastroduodenal ulcers, peptic unspecified peptic ulcer unspecified peptic ulcer (disorder) unspecified peptic ulcer nos unspecified peptic ulcer nos (disorder)
DOID	DOID:750
UMLS	C0030920
MeSH	D010437
SNOMED-CT	SNOMEDCT_US_2016_09_01:13200003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:36) C0024623 \| gastric cancer \| 6 C0023890 \| liver cirrhosis \| 3 C0001173 \| gastric outlet obstruction \| 3 C0001418 \| adenocarcinoma \| 2 C0017152 \| gastritis \| 2 C0278701 \| gastric adenocarcinoma \| 2 C0019360 \| herpes zoster \| 1 C0024523 \| malabsorption \| 1 C0004096 \| asthma \| 1 C0023890 \| cirrhosis \| 1 C0042373 \| vascular disease \| 1 C0020502 \| hyperparathyroidism \| 1 C0017601 \| glaucoma \| 1 C0022661 \| end-stage renal disease \| 1 C0014868 \| esophagitis \| 1 C0022658 \| renal disease \| 1 C0043121 \| wernicke's encephalopathy \| 1 C0011847 \| diabetes \| 1 C0019360 \| zoster \| 1 C0019284 \| diaphragmatic hernia \| 1 C0010068 \| coronary heart disease \| 1 C0014869 \| reflux esophagitis \| 1 C0085096 \| peripheral vascular disease \| 1 C0600260 \| obstructive pulmonary disease \| 1 C0011849 \| diabetes mellitus \| 1 C0008350 \| gallstones \| 1 C0017612 \| open angle glaucoma \| 1 C0030920 \| peptic ulcer \| 1 C0010068 \| coronary artery disease \| 1 C0003467 \| anxiety \| 1 C0018799 \| heart disease \| 1 C0030305 \| pancreatitis \| 1 C0024115 \| pulmonary disease \| 1 C0339573 \| primary open angle glaucoma \| 1 C0005586 \| bipolar disorder \| 1 C0024117 \| chronic obstructive pulmonary disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) EDN1 \| 1906 \| CTD_human IL1B \| 3553 \| CTD_human GAST \| 2520 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 3593 \| IL12B \| infer 4780 \| NFE2L2 \| infer 5742 \| PTGS1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:170) 6343 \| SCT \| DISEASES 4710 \| NDUFB4 \| DISEASES 27248 \| ERLEC1 \| DISEASES 9812 \| KIAA0141 \| DISEASES 28954 \| REM1 \| DISEASES 3002 \| GZMB \| DISEASES 1113 \| CHGA \| DISEASES 479 \| ATP12A \| DISEASES 2137 \| EXTL3 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 10392 \| NOD1 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 5539 \| PPY \| DISEASES 3558 \| IL2 \| DISEASES 3565 \| IL4 \| DISEASES 56920 \| SEMA3G \| DISEASES 4953 \| ODC1 \| DISEASES 8574 \| AKR7A2 \| DISEASES 1958 \| EGR1 \| DISEASES 654231 \| OCM \| DISEASES 54210 \| TREM1 \| DISEASES 3306 \| HSPA2 \| DISEASES 7425 \| VGF \| DISEASES 968 \| CD68 \| DISEASES 3630 \| INS \| DISEASES 9945 \| GFPT2 \| DISEASES 1401 \| CRP \| DISEASES 4922 \| NTS \| DISEASES 78986 \| DUSP26 \| DISEASES 2922 \| GRP \| DISEASES 2694 \| GIF \| DISEASES 4951 \| OCM2 \| DISEASES 26122 \| EPC2 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 1559 \| CYP2C9 \| DISEASES 9360 \| PPIG \| DISEASES 7450 \| VWF \| DISEASES 384 \| ARG2 \| DISEASES 6521 \| SLC4A1 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 8578 \| SCARF1 \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 3938 \| LCT \| DISEASES 2247 \| FGF2 \| DISEASES 5443 \| POMC \| DISEASES 1950 \| EGF \| DISEASES 7157 \| TP53 \| DISEASES 7462 \| LAT2 \| DISEASES 1392 \| CRH \| DISEASES 3176 \| HNMT \| DISEASES 3606 \| IL18 \| DISEASES 5805 \| PTS \| DISEASES 5741 \| PTH \| DISEASES 152273 \| FGD5 \| DISEASES 6750 \| SST \| DISEASES 3815 \| KIT \| DISEASES 7032 \| TFF2 \| DISEASES 7031 \| TFF1 \| DISEASES 114757 \| CYGB \| DISEASES 51127 \| TRIM17 \| DISEASES 389015 \| SLC9A4 \| DISEASES 886 \| CCKAR \| DISEASES 10109 \| ARPC2 \| DISEASES 152185 \| SPICE1 \| DISEASES 213 \| ALB \| DISEASES 8642 \| DCHS1 \| DISEASES 5479 \| PPIB \| DISEASES 6447 \| SCG5 \| DISEASES 8000 \| PSCA \| DISEASES 5617 \| PRL \| DISEASES 7200 \| TRH \| DISEASES 5066 \| PAM \| DISEASES 125 \| ADH1B \| DISEASES 200558 \| APLF \| DISEASES 54498 \| SMOX \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 5222 \| PGA5 \| DISEASES 6868 \| ADAM17 \| DISEASES 947 \| CD34 \| DISEASES 132243 \| H1FOO \| DISEASES 6863 \| TAC1 \| DISEASES 85302 \| FBF1 \| DISEASES 4843 \| NOS2 \| DISEASES 7485 \| WRB \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 8338 \| HIST2H2AC \| DISEASES 220323 \| OAF \| DISEASES 2152 \| F3 \| DISEASES 55589 \| BMP2K \| DISEASES 51738 \| GHRL \| DISEASES 887 \| CCKBR \| DISEASES 885 \| CCK \| DISEASES 4221 \| MEN1 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 875 \| CBS \| DISEASES 100506658 \| OCLN \| DISEASES 5265 \| SERPINA1 \| DISEASES 2695 \| GIP \| DISEASES 1510 \| CTSE \| DISEASES 26136 \| TES \| DISEASES 5697 \| PYY \| DISEASES 3360 \| HTR4 \| DISEASES 56477 \| CCL28 \| DISEASES 5742 \| PTGS1 \| DISEASES 9760 \| TOX \| DISEASES 4513 \| MT-CO2 \| DISEASES 9926 \| LPGAT1 \| DISEASES 5743 \| PTGS2 \| DISEASES 6279 \| S100A8 \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 23195 \| MDN1 \| DISEASES 2316 \| FLNA \| DISEASES 959 \| CD40LG \| DISEASES 1557 \| CYP2C19 \| DISEASES 7422 \| VEGFA \| DISEASES 5225 \| PGC \| DISEASES 5292 \| PIM1 \| DISEASES 286205 \| SCAI \| DISEASES 7099 \| TLR4 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 8859 \| STK19 \| DISEASES 2155 \| F7 \| DISEASES 3303 \| HSPA1A \| DISEASES 3305 \| HSPA1L \| DISEASES 3055 \| HCK \| DISEASES 9576 \| SPAG6 \| DISEASES 23412 \| COMMD3 \| DISEASES 3274 \| HRH2 \| DISEASES 79135 \| APOO \| DISEASES 1906 \| EDN1 \| DISEASES 1045 \| CDX2 \| DISEASES 402682 \| UFSP1 \| DISEASES 94 \| ACVRL1 \| DISEASES 6370 \| CCL25 \| DISEASES 2962 \| GTF2F1 \| DISEASES 1365 \| CLDN3 \| DISEASES 65010 \| SLC26A6 \| DISEASES 79924 \| ADM2 \| DISEASES 2919 \| CXCL1 \| DISEASES 594857 \| NPS \| DISEASES 2950 \| GSTP1 \| DISEASES 2641 \| GCG \| DISEASES 4295 \| MLN \| DISEASES 7124 \| TNF \| DISEASES 7866 \| IFRD2 \| DISEASES 9228 \| DLGAP2 \| DISEASES 4049 \| LTA \| DISEASES 4588 \| MUC6 \| DISEASES 389125 \| MUSTN1 \| DISEASES 3586 \| IL10 \| DISEASES 4583 \| MUC2 \| DISEASES 7884 \| SLBP \| DISEASES 10772 \| SRSF10 \| DISEASES 131 \| ADH7 \| DISEASES 4008 \| LMO7 \| DISEASES 4586 \| MUC5AC \| DISEASES 26298 \| EHF \| DISEASES 142891 \| SAMD8 \| DISEASES 246744 \| STH \| DISEASES 8972 \| MGAM \| DISEASES 51741 \| WWOX \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	828
Disease	peptic ulcer disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:28) HP:0012126 \| Gastric cancer \| 6 HP:0002239 \| Gastrointestinal hemorrhage \| 3 HP:0002584 \| Intestinal hemorrhage \| 3 HP:0012531 \| Pain \| 2 HP:0005231 \| Chronic gastritis \| 2 HP:0005263 \| Gastritis \| 2 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0100790 \| Hernia \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0002099 \| Asthma \| 1 HP:0006510 \| Chronic obstructive pulmonary disease \| 1 HP:0012108 \| Primary open angle glaucoma \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0000501 \| Glaucoma \| 1 HP:0000739 \| Anxiety \| 1 HP:0001945 \| Fever \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0100867 \| Duodenal stenosis/atresia \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0001081 \| Gallstones \| 1 HP:0000776 \| Diaphragmatic hernia \| 1 HP:0001733 \| Pancreatic inflammation \| 1

Disease ID	828
Disease	peptic ulcer disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0009450 \| infection \| 7 C0024623 \| gastric cancer \| 6 C0267373 \| intestinal bleeding \| 3 C0001173 \| gastric outlet obstruction \| 2 C0017152 \| gastritis \| 2 C0014868 \| esophagitis \| 1 C0850666 \| h. pylori infection \| 1 C0267055 \| erosive esophagitis \| 1 C0850666 \| helicobacter pylori infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:22)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10306114	17078001	5742	PTGS1	umls:C0030920	BeFree	The COX-1 A-842G/C50T SNP does not influence the risk for developing peptic ulcer bleeding.	0.008458305	2006	PTGS1	9	122370243	A	G
rs1045642	18644389	5243	ABCB1	umls:C0030920	BeFree	MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese.	0.008729747	2008	ABCB1	7	87509329	A	T,G
rs1045642	24815441	5243	ABCB1	umls:C0030920	BeFree	Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcer: a systemic review and meta-analysis.	0.008729747	2015	ABCB1	7	87509329	A	T,G
rs1045642	22001987	5243	ABCB1	umls:C0030920	BeFree	C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers.	0.008729747	2011	ABCB1	7	87509329	A	T,G
rs10509681	23267857	1559	CYP2C9	umls:C0030920	BeFree	We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C83 (rs11572080 and rs10509681), CYP2C84, CYP2C92, CYP2C93, CYP2C192, CYP2C193, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.	0.005276948	2013	CYP2C8	10	95038992	T	C
rs10509681	23267857	1558	CYP2C8	umls:C0030920	BeFree	We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C83 (rs11572080 and rs10509681), CYP2C84, CYP2C92, CYP2C93, CYP2C192, CYP2C193, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.	0.000271442	2013	CYP2C8	10	95038992	T	C
rs11572080	23267857	1559	CYP2C9	umls:C0030920	BeFree	We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C83 (rs11572080 and rs10509681), CYP2C84, CYP2C92, CYP2C93, CYP2C192, CYP2C193, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.	0.005276948	2013	CYP2C8	10	95067273	C	T
rs11572080	23267857	1558	CYP2C8	umls:C0030920	BeFree	We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C83 (rs11572080 and rs10509681), CYP2C84, CYP2C92, CYP2C93, CYP2C192, CYP2C193, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.	0.000271442	2013	CYP2C8	10	95067273	C	T
rs11614913	21073609	406938	MIR146A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	MIR196A2	12	53991815	C	T
rs11614913	21073609	574501	MIR499A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	MIR196A2	12	53991815	C	T
rs1330344	25243161	5742	PTGS1	umls:C0030920	BeFree	Impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.	0.008458305	2014	PTGS1	9	122369409	C	T
rs1799964	25368751	7124	TNF	umls:C0030920	BeFree	TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for increased TNFA transcription, could influence the risk of peptic ulceration.	0.016731045	2013	LTA;TNF;LOC100287329	6	31574531	T	C
rs1800629	25368751	7124	TNF	umls:C0030920	BeFree	TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for increased TNFA transcription, could influence the risk of peptic ulceration.	0.016731045	2013	TNF	6	31575254	G	A
rs1801282	18372284	5468	PPARG	umls:C0030920	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.005362824	2008	PPARG	3	12351626	C	G
rs1805192	18372284	5468	PPARG	umls:C0030920	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.005362824	2008	PPARG	3	12379739	C	G
rs2075820	17309748	7099	TLR4	umls:C0030920	BeFree	E266K CARD4/NOD1, but not the TLR4 gene polymorphism increases the risk of peptic ulceration in H. pylori-positive patients.	0.000271442	2007	NOD1	7	30452621	C	T
rs2075820	17309748	10392	NOD1	umls:C0030920	BeFree	E266K CARD4/NOD1, but not the TLR4 gene polymorphism increases the risk of peptic ulceration in H. pylori-positive patients.	0.000542884	2007	NOD1	7	30452621	C	T
rs2910164	21073609	406938	MIR146A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	LOC285628;MIR146A	5	160485411	C	G
rs2910164	21073609	574501	MIR499A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	LOC285628;MIR146A	5	160485411	C	G
rs3746444	21073609	574501	MIR499A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3746444	21073609	406938	MIR146A	umls:C0030920	BeFree	We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.	0.000271442	2010	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3842787	17078001	5742	PTGS1	umls:C0030920	BeFree	The COX-1 A-842G/C50T SNP does not influence the risk for developing peptic ulcer bleeding.	0.008458305	2006	PTGS1	9	122371228	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:13)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0030920	atropine	D001285	51-55-8	peptic ulcer	MESH:D010437	therapeutic	7034155
C0030920	celecoxib	D000068579	-	peptic ulcer	MESH:D010437	marker/mechanism	16897817
C0030920	cimetidine	D002927	51481-61-9	peptic ulcer	MESH:D010437	therapeutic	11421865
C0030920	diclofenac	D004008	15307-86-5	peptic ulcer	MESH:D010437	marker/mechanism	16897817
C0030920	indomethacin	D007213	53-86-1	peptic ulcer	MESH:D010437	marker/mechanism	11148446
C0030920	lansoprazole	D064747	-	peptic ulcer	MESH:D010437	therapeutic	11394734
C0030920	omeprazole	D009853	73590-58-6	peptic ulcer	MESH:D010437	marker/mechanism	8667442
C0030920	omeprazole	D009853	73590-58-6	peptic ulcer	MESH:D010437	therapeutic	10192720
C0030920	pantoprazole	C064276	102625-70-7	peptic ulcer	MESH:D010437	therapeutic	19837071
C0030920	piroxicam	D010894	36322-90-4	peptic ulcer	MESH:D010437	marker/mechanism	2957207
C0030920	spironolactone	D013148	1952/1/7	peptic ulcer	MESH:D010437	therapeutic	5569832
C0030920	sucralfate	D013392	54182-58-0	peptic ulcer	MESH:D010437	marker/mechanism	8667442
C0030920	tinidazole	D014011	19387-91-8	peptic ulcer	MESH:D010437	therapeutic	11394734

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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