PedAM

Pediatric Disease Annotations & Medicines


	peptic esophagitis

Disease ID	1069
Disease	peptic esophagitis
Definition	INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.
Synonym	esophagitides, peptic esophagitides, reflux esophagitis peptic esophagitis reflux esophagitis refluxing esophagitis, peptic esophagitis, peptic [disease/finding] esophagitis, reflux peptic esophagitides peptic oesophagitis peptic reflux disease peptic reflux disease (disorder) peptic reflux esophagitis peptic reflux oesophagitis reflux esophagitides reflux esophagitis reflux oesophagitis
DOID	DOID:13976
UMLS	C0014869
MeSH	D004942
SNOMED-CT	SNOMEDCT_US_2016_09_01:57643001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:1) C0019291 \| hiatus hernia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) CXCL8 \| 3576 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1557 \| CYP2C19 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:72) 55359 \| STYK1 \| DISEASES 6343 \| SCT \| DISEASES 9812 \| KIAA0141 \| DISEASES 479 \| ATP12A \| DISEASES 2862 \| MLNR \| DISEASES 27121 \| DKK4 \| DISEASES 1777 \| DNASE2 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 56920 \| SEMA3G \| DISEASES 654231 \| OCM \| DISEASES 2952 \| GSTT1 \| DISEASES 4951 \| OCM2 \| DISEASES 26122 \| EPC2 \| DISEASES 3569 \| IL6 \| DISEASES 490 \| ATP2B1 \| DISEASES 2294 \| FOXF1 \| DISEASES 495 \| ATP4A \| DISEASES 3553 \| IL1B \| DISEASES 3938 \| LCT \| DISEASES 53831 \| GPR84 \| DISEASES 7157 \| TP53 \| DISEASES 7462 \| LAT2 \| DISEASES 7032 \| TFF2 \| DISEASES 4056 \| LTC4S \| DISEASES 6352 \| CCL5 \| DISEASES 27306 \| HPGDS \| DISEASES 3577 \| CXCR1 \| DISEASES 213 \| ALB \| DISEASES 5066 \| PAM \| DISEASES 23627 \| PRND \| DISEASES 1857 \| DVL3 \| DISEASES 132243 \| H1FOO \| DISEASES 4843 \| NOS2 \| DISEASES 3855 \| KRT7 \| DISEASES 2520 \| GAST \| DISEASES 6546 \| SLC8A1 \| DISEASES 2689 \| GH2 \| DISEASES 55256 \| ADI1 \| DISEASES 23562 \| CLDN14 \| DISEASES 54681 \| P4HTM \| DISEASES 84639 \| IL1F10 \| DISEASES 1364 \| CLDN4 \| DISEASES 100506658 \| OCLN \| DISEASES 4638 \| MYLK \| DISEASES 3360 \| HTR4 \| DISEASES 5743 \| PTGS2 \| DISEASES 6279 \| S100A8 \| DISEASES 1557 \| CYP2C19 \| DISEASES 5225 \| PGC \| DISEASES 3274 \| HRH2 \| DISEASES 795 \| S100G \| DISEASES 1045 \| CDX2 \| DISEASES 402682 \| UFSP1 \| DISEASES 79400 \| NOX5 \| DISEASES 1365 \| CLDN3 \| DISEASES 4650 \| MYO9B \| DISEASES 594857 \| NPS \| DISEASES 2950 \| GSTP1 \| DISEASES 4295 \| MLN \| DISEASES 7124 \| TNF \| DISEASES 7866 \| IFRD2 \| DISEASES 389125 \| MUSTN1 \| DISEASES 4583 \| MUC2 \| DISEASES 338376 \| IFNE \| DISEASES 149466 \| C1orf210 \| DISEASES 4008 \| LMO7 \| DISEASES 4586 \| MUC5AC \| DISEASES 4850 \| CNOT4 \| DISEASES 11245 \| GPR176 \| DISEASES 51741 \| WWOX \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1069
Disease	peptic esophagitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:2) HP:0100790 \| Hernia \| 1 HP:0002036 \| Hiatus hernia \| 1

Disease ID	1069
Disease	peptic esophagitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1052133	18349297	4968	OGG1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	OGG1;CAMK1	3	9757089	C	G
rs1052133	18349297	7515	XRCC1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	OGG1;CAMK1	3	9757089	C	G
rs25487	18349297	4968	OGG1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	XRCC1	19	43551574	T	C
rs25487	18349297	7515	XRCC1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	XRCC1	19	43551574	T	C
rs386493716	18349297	4968	OGG1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	NA	NA	NA	NA	NA
rs386493716	18349297	7515	XRCC1	umls:C0014869	BeFree	In a population-based case-control study, we examined associations of the hOGG1 Ser 326 Cys, XRCC1 Arg 399 Gln, and XPD Lys 751 Gln polymorphisms with risk of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.	0.000271442	2008	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0014869	cimetidine	D002927	51481-61-9	esophagitis, peptic	MESH:D004942	therapeutic	7427548
C0014869	lansoprazole	D064747	-	esophagitis, peptic	MESH:D004942	therapeutic	10594396
C0014869	nizatidine	D016567	76963-41-2	esophagitis, peptic	MESH:D004942	therapeutic	15683433
C0014869	omeprazole	D009853	73590-58-6	esophagitis, peptic	MESH:D004942	therapeutic	11350494
C0014869	pantoprazole	C064276	102625-70-7	esophagitis, peptic	MESH:D004942	therapeutic	7762175

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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