PedAM

Pediatric Disease Annotations & Medicines


	pemphigus vulgaris

Disease ID	557
Disease	pemphigus vulgaris
Definition	An autoimmune blistering disorder. It is characterized by the presence of painful blisters and erosions in the skin and mucous membranes.
Synonym	pemphigus pv vulgaris pemphigus vulgaris (disorder) pemphigus, vulgaris pv - pemphigus vulgaris
Orphanet	ORPHANET:704
ICD10	ICD10CM:L10.0
UMLS	C0030809
SNOMED-CT	SNOMEDCT_US_2016_09_01:49420001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:26) C0014868 \| esophagitis \| 4 C0033860 \| psoriasis \| 3 C0030807 \| pemphigus \| 3 C0029456 \| osteoporosis \| 2 C0040128 \| thyroid disease \| 2 C0036220 \| kaposi's sarcoma \| 2 C0003864 \| arthritis \| 2 C1261473 \| sarcoma \| 2 C0034212 \| pyoderma \| 1 C0035309 \| retinopathy \| 1 C0017574 \| gingivitis \| 1 C0013295 \| duodenal ulcer \| 1 C0004623 \| bacterial infection \| 1 C0879615 \| stromal tumor \| 1 C0042769 \| virus infection \| 1 C0009324 \| ulcerative colitis \| 1 C0004623 \| bacterial infections \| 1 C0003873 \| rheumatoid arthritis \| 1 C0015230 \| cutaneous eruption \| 1 C0040128 \| thyroid diseases \| 1 C0031099 \| periodontitis \| 1 C0085652 \| pyoderma gangrenosum \| 1 C0007137 \| squamous cell carcinoma \| 1 C0238198 \| gastrointestinal stromal tumor \| 1 C0021053 \| immune disease \| 1 C0040137 \| thyroid nodule \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) 1830 \| DSG3 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3592 \| IL12A \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3554 \| IL1R1 \| infer 3557 \| IL1RN \| infer 3558 \| IL2 \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer 3569 \| IL6 \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:106) 6362 \| CCL18 \| DISEASES 1015 \| CDH17 \| DISEASES 7414 \| VCL \| DISEASES 4282 \| MIF \| DISEASES 5411 \| PNN \| DISEASES 6361 \| CCL17 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 2217 \| FCGRT \| DISEASES 973 \| CD79A \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 3111 \| HLA-DOA \| DISEASES 1007 \| CDH9 \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 1843 \| DUSP1 \| DISEASES 667 \| DST \| DISEASES 81578 \| COL21A1 \| DISEASES 6939 \| TCF15 \| DISEASES 1830 \| DSG3 \| DISEASES 1828 \| DSG1 \| DISEASES 1823 \| DSC1 \| DISEASES 3915 \| LAMC1 \| DISEASES 1144 \| CHRND \| DISEASES 3569 \| IL6 \| DISEASES 1829 \| DSG2 \| DISEASES 999 \| CDH1 \| DISEASES 57148 \| RALGAPB \| DISEASES 3552 \| IL1A \| DISEASES 55717 \| WDR11 \| DISEASES 28960 \| DCPS \| DISEASES 5317 \| PKP1 \| DISEASES 5443 \| POMC \| DISEASES 122481 \| AK7 \| DISEASES 255626 \| HIST1H2BA \| DISEASES 1824 \| DSC2 \| DISEASES 2220 \| FCN2 \| DISEASES 1145 \| CHRNE \| DISEASES 2215 \| FCGR3B \| DISEASES 27306 \| HPGDS \| DISEASES 27242 \| TNFRSF21 \| DISEASES 5055 \| SERPINB2 \| DISEASES 144568 \| A2ML1 \| DISEASES 2125 \| EVPL \| DISEASES 6037 \| RNASE3 \| DISEASES 81851 \| KRTAP1-1 \| DISEASES 80777 \| CYB5B \| DISEASES 5897 \| RAG2 \| DISEASES 5340 \| PLG \| DISEASES 56945 \| MRPS22 \| DISEASES 836 \| CASP3 \| DISEASES 8832 \| CD84 \| DISEASES 55584 \| CHRNA9 \| DISEASES 120103 \| SLC36A4 \| DISEASES 5339 \| PLEC \| DISEASES 940 \| CD28 \| DISEASES 10250 \| SRRM1 \| DISEASES 29110 \| TBK1 \| DISEASES 11187 \| PKP3 \| DISEASES 200162 \| SPAG17 \| DISEASES 5329 \| PLAUR \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 5493 \| PPL \| DISEASES 1308 \| COL17A1 \| DISEASES 79723 \| SUV39H2 \| DISEASES 50488 \| MINK1 \| DISEASES 6714 \| SRC \| DISEASES 728113 \| ANXA8L1 \| DISEASES 147409 \| DSG4 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 3135 \| HLA-G \| DISEASES 1825 \| DSC3 \| DISEASES 2214 \| FCGR3A \| DISEASES 3713 \| IVL \| DISEASES 284486 \| THEM5 \| DISEASES 4942 \| OAT \| DISEASES 8416 \| ANXA9 \| DISEASES 959 \| CD40LG \| DISEASES 2219 \| FCN1 \| DISEASES 3437 \| IFIT3 \| DISEASES 958 \| CD40 \| DISEASES 5328 \| PLAU \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 10673 \| TNFSF13B \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 8718 \| TNFRSF25 \| DISEASES 1832 \| DSP \| DISEASES 27032 \| ATP2C1 \| DISEASES 7106 \| TSPAN4 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 4719 \| NDUFS1 \| DISEASES 64065 \| PERP \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 387 \| RHOA \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 3586 \| IL10 \| DISEASES 51428 \| DDX41 \| DISEASES 930 \| CD19 \| DISEASES 488 \| ATP2A2 \| DISEASES 1006 \| CDH8 \| DISEASES 677833 \| SNORA54 \| DISEASES
Locus	(Waiting for update.)

Disease ID	557
Disease	pemphigus vulgaris
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:10) HP:0000163 \| Abnormality of the oral cavity HP:0001824 \| Weight loss HP:0002719 \| Recurrent infections HP:0008872 \| Feeding difficulties in infancy HP:0100792 \| Acantholysis HP:0008066 \| Abnormal blistering of the skin HP:0100838 \| Recurrent cutaneous abscess formation HP:0001025 \| Urticaria HP:0002960 \| Autoimmunity HP:0000987 \| Atypical scarring of skin
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:28) HP:0100792 \| Acantholysis \| 5 HP:0100633 \| Inflammation of the esophagus \| 4 HP:0008066 \| Skin bullae \| 3 HP:0003765 \| Psoriasis \| 3 HP:0001369 \| Arthritis \| 2 HP:0000820 \| Thyroid abnormality \| 2 HP:0100242 \| Sarcoma \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0100726 \| Kaposi's sarcoma \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0001298 \| Encephalopathy \| 1 HP:0002588 \| Duodenal ulcer \| 1 HP:0008069 \| Neoplasm of the skin \| 1 HP:0100825 \| Inflammation of the lips \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0100723 \| Gastrointestinal stroma tumor \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0100806 \| Sepsis \| 1 HP:0012531 \| Pain \| 1 HP:0030731 \| Carcinoma \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0000230 \| Inflamed gums \| 1 HP:0000999 \| Pyoderma \| 1 HP:0030318 \| Commissural cheilitis \| 1

Disease ID	557
Disease	pemphigus vulgaris
Manually Symptom	UMLS \| Name(Total Manually Symptoms:34) C2364133 \| infection C1962986 \| glaucoma C1334149 \| iatrogenic kaposi's sarcoma C1000483 \| anemia C0747479 \| periodontal infection C0740272 \| cryptococcal infection C0406347 \| disseminated superficial porokeratosis C0406252 \| podopompholyx C0376379 \| herpetic gingivostomatitis C0278701 \| gastric adenocarcinoma C0275583 \| pulmonary nocardiosis C0263540 \| onychomadesis C0263367 \| koebner phenomenon C0221150 \| odynophagia C0038826 \| superinfection C0037284 \| skin lesions C0037284 \| skin lesion C0036220 \| kaposi's sarcoma C0034065 \| pulmonary embolism C0029172 \| oral submucous fibrosis C0029166 \| oral manifestation C0027721 \| minimal change nephropathy C0027339 \| nail disease C0026896 \| myasthenia gravis C0022595 \| darier's disease C0022568 \| keratitis C0019348 \| herpes simplex virus infection C0019348 \| herpes simplex infection C0019158 \| hepatitis C0017577 \| desquamative gingivitis C0017531 \| castleman's disease C0016436 \| folliculitis C0014866 \| esophageal stenosis C0007097 \| epithelial carcinoma
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0036220 \| kaposi's sarcoma \| 2 C0017577 \| desquamative gingivitis \| 1 C0037284 \| skin lesions \| 1 C1334149 \| iatrogenic kaposi's sarcoma \| 1 C0029166 \| oral manifestation \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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