PedAM

Pediatric Disease Annotations & Medicines


	pelvic inflammatory disease

Disease ID	1059
Disease	pelvic inflammatory disease
Definition	A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
Synonym	[x]inflammatory diseases of female pelvic organs [x]inflammatory diseases of female pelvic organs (disorder) disease (pid), pelvic inflammatory disease pelvic inflammatory disease, inflammatory pelvic disease, pelvic inflammatory diseases, inflammatory pelvic diseases, pelvic inflammatory fem pelv inflam dis nos female pelvic infection female pelvic inflammation female pelvic inflammatory disease female pelvic inflammatory disease (disorder) female pelvic inflammatory disease nos female pelvic inflammatory disease nos (disorder) female pelvic inflammatory diseases nos female pelvic inflammatory diseases nos (disorder) inflam. dis.- pelvic inflamm dis pelvic inflamm pelvic dis inflammation pelvic inflammatory disease (pid), pelvic inflammatory disease of female pelvic organs inflammatory disease of female pelvic organs and tissues, nos inflammatory disease of female pelvic organs and/or tissues inflammatory disease of female pelvic organs and/or tissues (disorder) inflammatory disease of female pelvic organs and/or tissues [ambiguous] inflammatory disease, pelvic inflammatory diseases of female pelvic organs inflammatory diseases, pelvic inflammatory pelvic disease inflammatory pelvic diseases pelvic dis inflamm pelvic disease, inflammatory pelvic diseases, inflammatory pelvic inflam. disease nos pelvic inflamm dis pelvic inflammation pelvic inflammatory disease (pid) pelvic inflammatory disease [disease/finding] pelvic inflammatory disease nos pelvic inflammatory disease, (pid) pelvic inflammatory diseases pid - pelvic inflammatory disease pid, pelvic inflammatory disease unspecified inflammatory disease of female pelvic organs and tissues
DOID	DOID:1003
UMLS	C0242172
MeSH	D000292
SNOMED-CT	SNOMEDCT_US_2016_09_01:198130006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:33) C0242172 \| pelvic inflammatory disease \| 71 C0242172 \| pelvic inflammatory disease (pid) \| 25 C0008148 \| chlamydia \| 9 C0021359 \| infertility \| 4 C0007113 \| rectal cancer \| 4 C0009402 \| colorectal cancer \| 4 C0032987 \| ectopic pregnancy \| 3 C1140680 \| ovarian cancer \| 3 C1140680 \| ovarian ca \| 3 C0027051 \| myocardial infarct \| 2 C0014175 \| endometriosis \| 2 C0018081 \| gonorrhea \| 2 C0027051 \| myocardial infarction \| 2 C0476089 \| endometrial cancer \| 1 C0021843 \| bowel obstruction \| 1 C0040921 \| trichomoniasis \| 1 C0041296 \| tuberculosis \| 1 C0036130 \| salpingitis \| 1 C0032987 \| ectopic pregnancies \| 1 C0026934 \| mycoplasma \| 1 C0020538 \| hypertension \| 1 C0018081 \| gonorrhoea \| 1 C0227791 \| vaginal discharge \| 1 C0034220 \| pyosalpinx \| 1 C0476089 \| endometrial ca \| 1 C0042133 \| uterine fibroid \| 1 C0018081 \| gonococcal infection \| 1 C0012813 \| diverticulitis \| 1 C0008924 \| cleft lip \| 1 C0039128 \| syphilis \| 1 C0023267 \| fibroids \| 1 C0042133 \| uterine fibroids \| 1 C0031154 \| peritonitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 6347 \| CCL2 \| infer 6387 \| CXCL12 \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:154) 1080 \| CFTR \| DISEASES 4257 \| MGST1 \| DISEASES 2896 \| GRN \| DISEASES 1738 \| DLD \| DISEASES 26499 \| PLEK2 \| DISEASES 10423 \| CDIPT \| DISEASES 2137 \| EXTL3 \| DISEASES 27294 \| DHDH \| DISEASES 23581 \| CASP14 \| DISEASES 973 \| CD79A \| DISEASES 2931 \| GSK3A \| DISEASES 6347 \| CCL2 \| DISEASES 2597 \| GAPDH \| DISEASES 7167 \| TPI1 \| DISEASES 55856 \| ACOT13 \| DISEASES 9450 \| LY86 \| DISEASES 23435 \| TARDBP \| DISEASES 8655 \| DYNLL1 \| DISEASES 9271 \| PIWIL1 \| DISEASES 8189 \| SYMPK \| DISEASES 826 \| CAPNS1 \| DISEASES 7277 \| TUBA4A \| DISEASES 2658 \| GDF2 \| DISEASES 348 \| APOE \| DISEASES 25814 \| ATXN10 \| DISEASES 1401 \| CRP \| DISEASES 4678 \| NASP \| DISEASES 1116 \| CHI3L1 \| DISEASES 5920 \| RARRES3 \| DISEASES 10468 \| FST \| DISEASES 9038 \| TAAR5 \| DISEASES 3569 \| IL6 \| DISEASES 23205 \| ACSBG1 \| DISEASES 255488 \| RNF144B \| DISEASES 7097 \| TLR2 \| DISEASES 9480 \| ONECUT2 \| DISEASES 6558 \| SLC12A2 \| DISEASES 3553 \| IL1B \| DISEASES 28960 \| DCPS \| DISEASES 1119 \| CHKA \| DISEASES 7994 \| KAT6A \| DISEASES 11081 \| KERA \| DISEASES 144193 \| AMDHD1 \| DISEASES 663 \| BNIP2 \| DISEASES 10261 \| IGSF6 \| DISEASES 432 \| ASGR1 \| DISEASES 54858 \| PGPEP1 \| DISEASES 6872 \| TAF1 \| DISEASES 3176 \| HNMT \| DISEASES 196463 \| PLBD2 \| DISEASES 22808 \| MRAS \| DISEASES 1584 \| CYP11B1 \| DISEASES 6352 \| CCL5 \| DISEASES 5798 \| PTPRN \| DISEASES 7123 \| CLEC3B \| DISEASES 1672 \| DEFB1 \| DISEASES 5267 \| SERPINA4 \| DISEASES 143689 \| PIWIL4 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 9081 \| PRY \| DISEASES 442862 \| PRY2 \| DISEASES 1673 \| DEFB4A \| DISEASES 442866 \| PRYP4 \| DISEASES 7314 \| UBB \| DISEASES 157570 \| ESCO2 \| DISEASES 9934 \| P2RY14 \| DISEASES 8815 \| BANF1 \| DISEASES 6773 \| STAT2 \| DISEASES 1068 \| CETN1 \| DISEASES 10938 \| EHD1 \| DISEASES 5345 \| SERPINF2 \| DISEASES 3355 \| HTR1F \| DISEASES 1453 \| CSNK1D \| DISEASES 5663 \| PSEN1 \| DISEASES 81857 \| MED25 \| DISEASES 2242 \| FES \| DISEASES 2621 \| GAS6 \| DISEASES 10227 \| MFSD10 \| DISEASES 353164 \| TAS2R42 \| DISEASES 10376 \| TUBA1B \| DISEASES 10147 \| SUGP2 \| DISEASES 23236 \| PLCB1 \| DISEASES 6622 \| SNCA \| DISEASES 5269 \| SERPINB6 \| DISEASES 7430 \| EZR \| DISEASES 3329 \| HSPD1 \| DISEASES 4137 \| MAPT \| DISEASES 442865 \| PRYP3 \| DISEASES 29978 \| UBQLN2 \| DISEASES 1635 \| DCTD \| DISEASES 6421 \| SFPQ \| DISEASES 253260 \| RICTOR \| DISEASES 26151 \| NAT9 \| DISEASES 6364 \| CCL20 \| DISEASES 5602 \| MAPK10 \| DISEASES 11076 \| TPPP \| DISEASES 578 \| BAK1 \| DISEASES 916 \| CD3E \| DISEASES 7096 \| TLR1 \| DISEASES 9846 \| GAB2 \| DISEASES 343035 \| RD3 \| DISEASES 5788 \| PTPRC \| DISEASES 6375 \| XCL1 \| DISEASES 117145 \| THEM4 \| DISEASES 9531 \| BAG3 \| DISEASES 5016 \| OVGP1 \| DISEASES 2316 \| FLNA \| DISEASES 1369 \| CPN1 \| DISEASES 2633 \| GBP1 \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 3725 \| JUN \| DISEASES 10406 \| WFDC2 \| DISEASES 7099 \| TLR4 \| DISEASES 9968 \| MED12 \| DISEASES 5252 \| PHF1 \| DISEASES 55937 \| APOM \| DISEASES 57449 \| PLEKHG5 \| DISEASES 1832 \| DSP \| DISEASES 4507 \| MTAP \| DISEASES 6019 \| RLN2 \| DISEASES 10333 \| TLR6 \| DISEASES 114899 \| C1QTNF3 \| DISEASES 54545 \| MTMR12 \| DISEASES 10675 \| CSPG5 \| DISEASES 9467 \| SH3BP5 \| DISEASES 163126 \| EID2 \| DISEASES 50838 \| TAS2R13 \| DISEASES 55022 \| PID1 \| DISEASES 114609 \| TIRAP \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 6046 \| BRD2 \| DISEASES 2919 \| CXCL1 \| DISEASES 2868 \| GRK4 \| DISEASES 54826 \| GIN1 \| DISEASES 5425 \| POLD2 \| DISEASES 7311 \| UBA52 \| DISEASES 79027 \| ZNF655 \| DISEASES 7124 \| TNF \| DISEASES 1139 \| CHRNA7 \| DISEASES 9351 \| SLC9A3R2 \| DISEASES 55655 \| NLRP2 \| DISEASES 3586 \| IL10 \| DISEASES 643836 \| ZFP62 \| DISEASES 259296 \| TAS2R50 \| DISEASES 345611 \| IRGM \| DISEASES 23741 \| EID1 \| DISEASES 503542 \| SPRN \| DISEASES 259292 \| TAS2R46 \| DISEASES 50840 \| TAS2R14 \| DISEASES 11201 \| POLI \| DISEASES 100302740 \| FAS-AS1 \| DISEASES 26812 \| SNORD37 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1059
Disease	pelvic inflammatory disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:12) HP:0000789 \| Infertility \| 4 HP:0100699 \| Scarring \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0030127 \| Endometriosis \| 2 HP:0012531 \| Pain \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0005214 \| Bowel obstruction \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0000822 \| Hypertension \| 1 HP:0000131 \| Uterine leiomyoma \| 1 HP:0002586 \| Peritonitis \| 1 HP:0001945 \| Fever \| 1

Disease ID	1059
Disease	pelvic inflammatory disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0009450 \| infection \| 17 C0021311 \| infections \| 7 C0021359 \| infertility \| 4 C0041343 \| tubo-ovarian abscess \| 3 C0008151 \| chlamydia trachomatis \| 2 C0238356 \| perihepatitis \| 1 C0008149 \| chlamydial infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1898830	24848367	7097	TLR2	umls:C0242172	BeFree	African-American women with PID carrying the AA genotype for TLR2 SNP rs1898830 had a threefold increased rate of BV/intermediate flora (OR 2.9, 95% CI 1.2 to 7.3).	0.000542884	2014	TLR2	4	153687301	A	G
rs1927911	22238472	7099	TLR4	umls:C0242172	BeFree	Women with PID who carried the TLR4 rs1927911 CC genotype had significantly increased odds of C. trachomatis (OR, 3.7; 95% CI, 1.6-8.8; P = .002).	0.000814326	2012	TLR4	9	117707776	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0242172	amikacin	D000583	37517-28-5	pelvic inflammatory disease	MESH:D000292	therapeutic	1856146
C0242172	ofloxacin	D015242	82419-36-1	pelvic inflammatory disease	MESH:D000292	therapeutic	14511503

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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