PedAM
Pediatric Disease Annotations & Medicines
| pathological gambling | ||||
| Disease ID | 1062 |
|---|---|
| Disease | pathological gambling |
| Definition | A disorder characterized by a preoccupation with gambling and the excitement that gambling with increasing risk provides. Pathological gamblers are unable to cut back on their gambling, despite the fact that it may lead them to lie, steal, or lose a significant relationship, job, or educational opportunity. |
| Synonym | addiction gambling addictions gambling compulsive gambling compulsive gambling (disorder) compulsive gambling (finding) gambling addiction gambling compulsive gambling disorder gambling pathol gambling pathological gambling, pathologic gambling, pathological gamblings, pathological pathol gambling pathological gambling (disorder) pathological gambling disorder pathological gamblings |
| OMIM | |
| DOID | |
| ICD10 | |
| UMLS | C0030662 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:10) C0030567 | parkinson disease | 4 C0030567 | parkinson's disease | 4 C0021122 | impulse control disorders | 2 C0221765 | chronic schizophrenia | 1 C0013473 | eating disorder | 1 C0338451 | frontotemporal dementia | 1 C1510472 | drug addiction | 1 C0031212 | personality disorders | 1 C0004936 | mental disorders | 1 C0497327 | dementia | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:2) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:70) 1815 | DRD4 | DISEASES 11211 | FZD10 | DISEASES 5754 | PTK7 | DISEASES 374291 | NDUFS7 | DISEASES 5552 | SRGN | DISEASES 2354 | FOSB | DISEASES 9509 | ADAMTS2 | DISEASES 51540 | SCLY | DISEASES 29113 | C6orf15 | DISEASES 6532 | SLC6A4 | DISEASES 217 | ALDH2 | DISEASES 10049 | DNAJB6 | DISEASES 4969 | OGN | DISEASES 30846 | EHD2 | DISEASES 64083 | GOLPH3 | DISEASES 10058 | ABCB6 | DISEASES 51083 | GAL | DISEASES 55749 | CCAR1 | DISEASES 6531 | SLC6A3 | DISEASES 3358 | HTR2C | DISEASES 5531 | PPP4C | DISEASES 2904 | GRIN2B | DISEASES 4154 | MBNL1 | DISEASES 256471 | MFSD8 | DISEASES 6571 | SLC18A2 | DISEASES 6632 | SNRPD1 | DISEASES 4054 | LTBP3 | DISEASES 116844 | LRG1 | DISEASES 9482 | STX8 | DISEASES 1816 | DRD5 | DISEASES 2915 | GRM5 | DISEASES 255239 | ANKK1 | DISEASES 157570 | ESCO2 | DISEASES 8557 | TCAP | DISEASES 3642 | INSM1 | DISEASES 3350 | HTR1A | DISEASES 2744 | GLS | DISEASES 4026 | LPP | DISEASES 4691 | NCL | DISEASES 23017 | FAIM2 | DISEASES 1812 | DRD1 | DISEASES 57142 | RTN4 | DISEASES 4128 | MAOA | DISEASES 1544 | CYP1A2 | DISEASES 875 | CBS | DISEASES 8936 | WASF1 | DISEASES 1002 | CDH4 | DISEASES 1312 | COMT | DISEASES 1813 | DRD2 | DISEASES 9446 | GSTO1 | DISEASES 3351 | HTR1B | DISEASES 5832 | ALDH18A1 | DISEASES 1557 | CYP2C19 | DISEASES 2902 | GRIN1 | DISEASES 5453 | POU3F1 | DISEASES 4878 | NPPA | DISEASES 4129 | MAOB | DISEASES 3356 | HTR2A | DISEASES 8544 | PIR | DISEASES 2618 | GART | DISEASES 7436 | VLDLR | DISEASES 1814 | DRD3 | DISEASES 9467 | SH3BP5 | DISEASES 4501 | MT1X | DISEASES 152 | ADRA2C | DISEASES 4988 | OPRM1 | DISEASES 10163 | WASF2 | DISEASES 862 | RUNX1T1 | DISEASES 1154 | CISH | DISEASES 627 | BDNF | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1062 |
|---|---|
| Disease | pathological gambling |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:6) HP:0100710 | Impulsivity | 5 HP:0000726 | Dementia | 1 HP:0012075 | Personality disorder | 1 HP:0030858 | Addictive behavior | 1 HP:0002145 | Frontotemporal dementia | 1 HP:0000734 | Disinhibition | 1 |
| Disease ID | 1062 |
|---|---|
| Disease | pathological gambling |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:8) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10812227 | 22780124 | 11211 | FZD10 | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | VLDLR-AS1 | 9 | 2548556 | C | T |
| rs10812227 | 22780124 | 7436 | VLDLR | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | VLDLR-AS1 | 9 | 2548556 | C | T |
| rs1106076 | 22780124 | 11211 | FZD10 | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | NA | 7 | 5581212 | C | G |
| rs1106076 | 22780124 | 7436 | VLDLR | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | NA | 7 | 5581212 | C | G |
| rs12305135 | 22780124 | 7436 | VLDLR | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | NA | 12 | 130150660 | T | C |
| rs12305135 | 22780124 | 11211 | FZD10 | umls:C0030662 | BeFree | Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. | 0.000271442 | 2013 | NA | 12 | 130150660 | T | C |
| rs386602276 | 22740152 | 3356 | HTR2A | umls:C0030662 | BeFree | A significant association of the C/C genotype of the serotonin receptor 2A T102C (rs 6313) polymorphism and the PG phenotype was observed [OR = 1.7 (1.1-3.4)]. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs6313 | 22740152 | 3356 | HTR2A | umls:C0030662 | BeFree | A significant association of the C/C genotype of the serotonin receptor 2A T102C (rs 6313) polymorphism and the PG phenotype was observed [OR = 1.7 (1.1-3.4)]. | 0.000271442 | 2013 | HTR2A | 13 | 46895805 | G | A |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:5) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 6 | 16343056 | rs9383153 | A | G | rs9383153 | 22780124 | 5.00E-06 | NA | 0.33 | [0.19-0.47] unit increase | 1,312 twins from 894 families | NOPOP(1312) | ALL(1312) | NOPOP(1312) | ALL(1312) | Gambling | HPOID:0100851 | Abnormal emotion/affect behavior | DOID:12399 | pathological gambling | D005715 | Gambling | NA | NA | Conduct disorder | rs9383153-A | Twin Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't |
| 9 | 2548556 | rs10812227 | C | T | rs10812227 | 22780124 | 5.00E-06 | NA | 0.22 | [0.13-0.32] unit increase | 1,312 twins from 894 families | NOPOP(1312) | ALL(1312) | NOPOP(1312) | ALL(1312) | Gambling | HPOID:0100851 | Abnormal emotion/affect behavior | DOID:12399 | pathological gambling | D005715 | Gambling | NA | NA | Conduct disorder | rs10812227-C | Twin Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't |
| 9 | 2551654 | rs12237653 | T | C | rs12237653 | 22780124 | 3.00E-06 | NA | 0.23 | [0.13-0.32] unit increase | 1,312 twins from 894 families | NOPOP(1312) | ALL(1312) | NOPOP(1312) | ALL(1312) | Gambling | HPOID:0100851 | Abnormal emotion/affect behavior | DOID:12399 | pathological gambling | D005715 | Gambling | NA | NA | Conduct disorder | rs12237653-T | Twin Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't |
| 12 | 130630935 | rs11060736 | T | C | rs11060736 | 22780124 | 4.00E-06 | NA | 0.29 | [0.16-0.41] unit decrease | 1,312 twins from 894 families | NOPOP(1312) | ALL(1312) | NOPOP(1312) | ALL(1312) | Gambling | HPOID:0100851 | Abnormal emotion/affect behavior | DOID:12399 | pathological gambling | D005715 | Gambling | NA | NA | Conduct disorder | rs11060736-T | Twin Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't |
| 16 | 56725173 | rs8064100 | A | G | rs8064100 | 22780124 | 3.00E-06 | NA | 0.15 | [0.087-0.209] unit decrease | 1,312 twins from 894 families | NOPOP(1312) | ALL(1312) | NOPOP(1312) | ALL(1312) | Gambling | HPOID:0100851 | Abnormal emotion/affect behavior | DOID:12399 | pathological gambling | D005715 | Gambling | NA | NA | Conduct disorder | rs8064100-A | Twin Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |