PedAM

Pediatric Disease Annotations & Medicines


	paraplegia

Disease ID	430
Disease	paraplegia
Definition	Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Synonym	extremities lower paralysis extremity paralysis, lower leg paralysis lower paraplegia paralysis of both lower limbs paralysis, legs paralysis, lower extremities paralysis, lower limbs paraplegia (complete or partial paralysis of legs) paraplegia (disorder) paraplegia [disease/finding] paraplegia nos paraplegia, lower paraplegias
DOID	DOID:607
UMLS	C0030486
MeSH	D010264
SNOMED-CT	SNOMEDCT_US_2016_09_01:60389000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:52) C0022116 \| ischemia \| 7 C0442874 \| neuropathy \| 6 C0004134 \| ataxia \| 4 C0007758 \| cerebellar ataxia \| 4 C0026975 \| myelitis \| 4 C0270921 \| axonal neuropathy \| 4 C0029124 \| optic atrophy \| 3 C0003486 \| aortic aneurysm \| 2 C0039730 \| thalassemia \| 2 C0011127 \| pressure sores \| 2 C0025362 \| mental retardation \| 2 C0031117 \| peripheral neuropathy \| 2 C0029132 \| optic neuropathy \| 1 C0206754 \| neuroendocrine tumor \| 1 C0007222 \| cardiovascular disease \| 1 C0029438 \| gorham's disease \| 1 C0034372 \| tetraplegia \| 1 C0017919 \| glycogen storage disease \| 1 C0001080 \| achondroplasia \| 1 C0018916 \| hemangioma \| 1 C0022821 \| kyphosis \| 1 C0019562 \| von hippel lindau syndrome \| 1 C0037944 \| spinal stenosis \| 1 C0018099 \| gout \| 1 C0038012 \| spondylitis \| 1 C0024623 \| gastric cancer \| 1 C0152025 \| polyneuropathy \| 1 C0035078 \| renal failure \| 1 C1261473 \| sarcoma \| 1 C0024236 \| lymphoedema \| 1 C0041296 \| tuberculosis \| 1 C0695242 \| neurogenic bowel \| 1 C0005283 \| beta thalassemia \| 1 C0812437 \| oculodentodigital dysplasia \| 1 C0151313 \| sensory neuropathy \| 1 C0022116 \| ischaemia \| 1 C0027873 \| neuromyelitis optica \| 1 C0235025 \| motor neuropathy \| 1 C0042373 \| vascular disease \| 1 C0007760 \| cerebellar dysfunction \| 1 C0013502 \| hydatid cyst \| 1 C0028738 \| nystagmus \| 1 C0162871 \| abdominal aortic aneurysm \| 1 C0221069 \| anterior spinal artery syndrome \| 1 C0004943 \| behcet's disease \| 1 C0037928 \| myelopathy \| 1 C0086543 \| cataracts \| 1 C0011649 \| dermoid cyst \| 1 C0020538 \| hypertension \| 1 C0019937 \| horner's syndrome \| 1 C0497327 \| dementia \| 1 C0031485 \| phenylketonuria \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:56) AP4E1 \| 23431 \| UniProtKB-KW C12orf65 \| 91574 \| UniProtKB-KW REEP1 \| 65055 \| UniProtKB-KW REEP2 \| 51308 \| UniProtKB-KW SLC33A1 \| 9197 \| UniProtKB-KW KIF1A \| 547 \| UniProtKB-KW SPAST \| 6683 \| UniProtKB-KW AP4M1 \| 9179 \| UniProtKB-KW UCHL1 \| 7345 \| UniProtKB-KW PNPLA6 \| 10908 \| UniProtKB-KW FA2H \| 79152 \| UniProtKB-KW CYP7B1 \| 9420 \| UniProtKB-KW KIF5A \| 3798 \| UniProtKB-KW ERLIN2 \| 11160 \| UniProtKB-KW HSPD1 \| 3329 \| UniProtKB-KW PLP1 \| 5354 \| UniProtKB-KW HACE1 \| 57531 \| UniProtKB-KW SPG21 \| 51324 \| UniProtKB-KW SPG7 \| 6687 \| CTD_human;UniProtKB-KW ARL6IP1 \| 23204 \| UniProtKB-KW ALDH18A1 \| 5832 \| UniProtKB-KW DDHD1 \| 80821 \| UniProtKB-KW DDHD2 \| 23259 \| UniProtKB-KW GJC2 \| 57165 \| UniProtKB-KW TFG \| 10342 \| UniProtKB-KW CAPN1 \| 823 \| UniProtKB-KW TECPR2 \| 9895 \| UniProtKB-KW ENTPD1 \| 953 \| UniProtKB-KW L1CAM \| 3897 \| UniProtKB-KW;GHR BSCL2 \| 26580 \| UniProtKB-KW AP5Z1 \| 9907 \| UniProtKB-KW DSTYK \| 25778 \| UniProtKB-KW VPS37A \| 137492 \| UniProtKB-KW KIDINS220 \| 57498 \| UniProtKB-KW NIPA1 \| 123606 \| UniProtKB-KW ERLIN1 \| 10613 \| UniProtKB-KW ATP13A2 \| 23400 \| UniProtKB-KW MAG \| 4099 \| UniProtKB-KW AMPD2 \| 271 \| UniProtKB-KW GBA2 \| 57704 \| UniProtKB-KW NT5C2 \| 22978 \| UniProtKB-KW ATL1 \| 51062 \| UniProtKB-KW KLC2 \| 64837 \| UniProtKB-KW CYP2U1 \| 113612 \| UniProtKB-KW C19orf12 \| 83636 \| UniProtKB-KW AP4B1 \| 10717 \| UniProtKB-KW ZFYVE27 \| 118813 \| UniProtKB-KW ZFYVE26 \| 23503 \| UniProtKB-KW CPT1C \| 126129 \| UniProtKB-KW AP4S1 \| 11154 \| UniProtKB-KW FARS2 \| 10667 \| UniProtKB-KW SPG11 \| 80208 \| UniProtKB-KW SPG20 \| 23111 \| UniProtKB-KW;GHR B4GALNT1 \| 2583 \| UniProtKB-KW RTN2 \| 6253 \| UniProtKB-KW IBA57 \| 200205 \| UniProtKB-KW
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 9197 \| SLC33A1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:464) 53844 \| COPG2IT1 \| DISEASES 54860 \| MS4A12 \| DISEASES 6591 \| SNAI2 \| DISEASES 1015 \| CDH17 \| DISEASES 57595 \| PDZD4 \| DISEASES 22846 \| VASH1 \| DISEASES 51324 \| SPG21 \| DISEASES 7051 \| TGM1 \| DISEASES 8086 \| AAAS \| DISEASES 410 \| ARSA \| DISEASES 2999 \| GZMH \| DISEASES 11154 \| AP4S1 \| DISEASES 9517 \| SPTLC2 \| DISEASES 7443 \| VRK1 \| DISEASES 57473 \| ZNF512B \| DISEASES 5173 \| PDYN \| DISEASES 10084 \| PQBP1 \| DISEASES 282808 \| RAB40AL \| DISEASES 51090 \| PLLP \| DISEASES 79152 \| FA2H \| DISEASES 9028 \| RHBDL1 \| DISEASES 54332 \| GDAP1 \| DISEASES 3972 \| LHB \| DISEASES 7040 \| TGFB1 \| DISEASES 10226 \| PLIN3 \| DISEASES 6671 \| SP4 \| DISEASES 5054 \| SERPINE1 \| DISEASES 4232 \| MEST \| DISEASES 8721 \| EDF1 \| DISEASES 23064 \| SETX \| DISEASES 657 \| BMPR1A \| DISEASES 6347 \| CCL2 \| DISEASES 1277 \| COL1A1 \| DISEASES 2026 \| ENO2 \| DISEASES 1337 \| COX6A1 \| DISEASES 2822 \| GPLD1 \| DISEASES 4015 \| LOX \| DISEASES 1007 \| CDH9 \| DISEASES 150465 \| TTL \| DISEASES 92840 \| REEP6 \| DISEASES 3336 \| HSPE1 \| DISEASES 6549 \| SLC9A2 \| DISEASES 6697 \| SPR \| DISEASES 8317 \| CDC7 \| DISEASES 9927 \| MFN2 \| DISEASES 9525 \| VPS4B \| DISEASES 23435 \| TARDBP \| DISEASES 10342 \| TFG \| DISEASES 80218 \| NAA50 \| DISEASES 9409 \| PEX16 \| DISEASES 7374 \| UNG \| DISEASES 28981 \| IFT81 \| DISEASES 6615 \| SNAI1 \| DISEASES 6662 \| SOX9 \| DISEASES 8192 \| CLPP \| DISEASES 6253 \| RTN2 \| DISEASES 7389 \| UROD \| DISEASES 402 \| ARL2 \| DISEASES 6945 \| MLX \| DISEASES 8139 \| GAN \| DISEASES 968 \| CD68 \| DISEASES 83855 \| KLF16 \| DISEASES 3630 \| INS \| DISEASES 23503 \| ZFYVE26 \| DISEASES 84271 \| POLDIP3 \| DISEASES 9253 \| NUMBL \| DISEASES 84660 \| CCDC62 \| DISEASES 91574 \| C12orf65 \| DISEASES 2670 \| GFAP \| DISEASES 1327 \| COX4I1 \| DISEASES 10328 \| EMC8 \| DISEASES 23199 \| GSE1 \| DISEASES 8500 \| PPFIA1 \| DISEASES 79727 \| LIN28A \| DISEASES 51308 \| REEP2 \| DISEASES 27183 \| VPS4A \| DISEASES 1401 \| CRP \| DISEASES 3508 \| IGHMBP2 \| DISEASES 1965 \| EIF2S1 \| DISEASES 10752 \| CHL1 \| DISEASES 10717 \| AP4B1 \| DISEASES 50640 \| PNPLA8 \| DISEASES 1783 \| DYNC1LI2 \| DISEASES 1144 \| CHRND \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 89953 \| KLC4 \| DISEASES 1134 \| CHRNA1 \| DISEASES 2581 \| GALC \| DISEASES 4001 \| LMNB1 \| DISEASES 55745 \| AP5M1 \| DISEASES 999 \| CDH1 \| DISEASES 5159 \| PDGFRB \| DISEASES 23431 \| AP4E1 \| DISEASES 80208 \| SPG11 \| DISEASES 51156 \| SERPINA10 \| DISEASES 9172 \| MYOM2 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 10558 \| SPTLC1 \| DISEASES 6845 \| VAMP7 \| DISEASES 6855 \| SYP \| DISEASES 3553 \| IL1B \| DISEASES 5582 \| PRKCG \| DISEASES 9559 \| VPS26A \| DISEASES 54414 \| SIAE \| DISEASES 23095 \| KIF1B \| DISEASES 55669 \| MFN1 \| DISEASES 10382 \| TUBB4A \| DISEASES 1615 \| DARS \| DISEASES 57679 \| ALS2 \| DISEASES 200576 \| PIKFYVE \| DISEASES 54847 \| SIDT1 \| DISEASES 6722 \| SRF \| DISEASES 11059 \| WWP1 \| DISEASES 6713 \| SQLE \| DISEASES 347902 \| AMIGO2 \| DISEASES 51411 \| BIN2 \| DISEASES 6252 \| RTN1 \| DISEASES 2252 \| FGF7 \| DISEASES 146057 \| TTBK2 \| DISEASES 1009 \| CDH11 \| DISEASES 81631 \| MAP1LC3B \| DISEASES 2588 \| GALNS \| DISEASES 6687 \| SPG7 \| DISEASES 1000 \| CDH2 \| DISEASES 10939 \| AFG3L2 \| DISEASES 9775 \| EIF4A3 \| DISEASES 126410 \| CYP4F22 \| DISEASES 207 \| AKT1 \| DISEASES 9027 \| NAT8 \| DISEASES 5868 \| RAB5A \| DISEASES 10769 \| PLK2 \| DISEASES 23092 \| ARHGAP26 \| DISEASES 10667 \| FARS2 \| DISEASES 6567 \| SLC16A2 \| DISEASES 11160 \| ERLIN2 \| DISEASES 123 \| PLIN2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 6768 \| ST14 \| DISEASES 823 \| CAPN1 \| DISEASES 22948 \| CCT5 \| DISEASES 23657 \| SLC7A11 \| DISEASES 4718 \| NDUFC2 \| DISEASES 51594 \| NBAS \| DISEASES 7082 \| TJP1 \| DISEASES 26353 \| HSPB8 \| DISEASES 2895 \| GRID2 \| DISEASES 57724 \| EPG5 \| DISEASES 5741 \| PTH \| DISEASES 8526 \| DGKE \| DISEASES 404550 \| C16orf74 \| DISEASES 351 \| APP \| DISEASES 9510 \| ADAMTS1 \| DISEASES 10120 \| ACTR1B \| DISEASES 6285 \| S100B \| DISEASES 5130 \| PCYT1A \| DISEASES 126133 \| ALDH16A1 \| DISEASES 347730 \| LRRTM1 \| DISEASES 84661 \| DPY30 \| DISEASES 72 \| ACTG2 \| DISEASES 54738 \| FEV \| DISEASES 213 \| ALB \| DISEASES 5500 \| PPP1CB \| DISEASES 84315 \| MON1A \| DISEASES 90390 \| MED30 \| DISEASES 9907 \| AP5Z1 \| DISEASES 25879 \| DCAF13 \| DISEASES 84889 \| SLC7A3 \| DISEASES 219938 \| SPATA19 \| DISEASES 79053 \| ALG8 \| DISEASES 339302 \| CPLX4 \| DISEASES 90678 \| LRSAM1 \| DISEASES 80150 \| ASRGL1 \| DISEASES 79058 \| ASPSCR1 \| DISEASES 3308 \| HSPA4 \| DISEASES 1140 \| CHRNB1 \| DISEASES 260434 \| PYDC1 \| DISEASES 51375 \| SNX7 \| DISEASES 136647 \| MPLKIP \| DISEASES 5354 \| PLP1 \| DISEASES 3708 \| ITPR1 \| DISEASES 9331 \| B4GALT6 \| DISEASES 23204 \| ARL6IP1 \| DISEASES 84233 \| TMEM126A \| DISEASES 2720 \| GLB1 \| DISEASES 3799 \| KIF5B \| DISEASES 2147 \| F2 \| DISEASES 5376 \| PMP22 \| DISEASES 5340 \| PLG \| DISEASES 572 \| BAD \| DISEASES 947 \| CD34 \| DISEASES 9420 \| CYP7B1 \| DISEASES 136259 \| KLF14 \| DISEASES 836 \| CASP3 \| DISEASES 5870 \| RAB6A \| DISEASES 348938 \| NIPAL4 \| DISEASES 65125 \| WNK1 \| DISEASES 57231 \| SNX14 \| DISEASES 80025 \| PANK2 \| DISEASES 8636 \| SSNA1 \| DISEASES 3737 \| KCNA2 \| DISEASES 7915 \| ALDH5A1 \| DISEASES 8496 \| PPFIBP1 \| DISEASES 64837 \| KLC2 \| DISEASES 283316 \| CD163L1 \| DISEASES 2824 \| GPM6B \| DISEASES 8411 \| EEA1 \| DISEASES 8575 \| PRKRA \| DISEASES 10730 \| YME1L1 \| DISEASES 137492 \| VPS37A \| DISEASES 58492 \| ZNF77 \| DISEASES 170825 \| GSX2 \| DISEASES 126129 \| CPT1C \| DISEASES 2653 \| GCSH \| DISEASES 80207 \| OPA3 \| DISEASES 10749 \| KIF1C \| DISEASES 6683 \| SPAST \| DISEASES 29906 \| ST8SIA5 \| DISEASES 79075 \| DSCC1 \| DISEASES 3039 \| HBA1 \| DISEASES 547 \| KIF1A \| DISEASES 51010 \| EXOSC3 \| DISEASES 25915 \| NDUFAF3 \| DISEASES 80031 \| SEMA6D \| DISEASES 400359 \| C15orf53 \| DISEASES 55486 \| PARL \| DISEASES 349149 \| GJC3 \| DISEASES 9919 \| SEC16A \| DISEASES 5663 \| PSEN1 \| DISEASES 5178 \| PEG3 \| DISEASES 55432 \| YOD1 \| DISEASES 80821 \| DDHD1 \| DISEASES 23400 \| ATP13A2 \| DISEASES 145942 \| TMCO5A \| DISEASES 51218 \| GLRX5 \| DISEASES 66008 \| TRAK2 \| DISEASES 22906 \| TRAK1 \| DISEASES 9798 \| IST1 \| DISEASES 388962 \| BOLA3 \| DISEASES 796 \| CALCA \| DISEASES 1485 \| CTAG1B \| DISEASES 25987 \| TSKU \| DISEASES 4088 \| SMAD3 \| DISEASES 8398 \| PLA2G6 \| DISEASES 113612 \| CYP2U1 \| DISEASES 3916 \| LAMP1 \| DISEASES 11104 \| KATNA1 \| DISEASES 8541 \| PPFIA3 \| DISEASES 1174 \| AP1S1 \| DISEASES 3842 \| TNPO1 \| DISEASES 123606 \| NIPA1 \| DISEASES 79621 \| RNASEH2B \| DISEASES 3300 \| DNAJB2 \| DISEASES 23321 \| TRIM2 \| DISEASES 84545 \| MRPL43 \| DISEASES 3329 \| HSPD1 \| DISEASES 80320 \| SP6 \| DISEASES 2583 \| B4GALNT1 \| DISEASES 3178 \| HNRNPA1 \| DISEASES 27255 \| CNTN6 \| DISEASES 6049 \| RNF6 \| DISEASES 10166 \| SLC25A15 \| DISEASES 3198 \| HOXA1 \| DISEASES 26053 \| AUTS2 \| DISEASES 10313 \| RTN3 \| DISEASES 1003 \| CDH5 \| DISEASES 1499 \| CTNNB1 \| DISEASES 56704 \| JPH1 \| DISEASES 6483 \| ST3GAL2 \| DISEASES 4734 \| NEDD4 \| DISEASES 224 \| ALDH3A2 \| DISEASES 3921 \| RPSA \| DISEASES 6275 \| S100A4 \| DISEASES 5325 \| PLAGL1 \| DISEASES 23111 \| SPG20 \| DISEASES 1785 \| DNM2 \| DISEASES 51287 \| COA4 \| DISEASES 118813 \| ZFYVE27 \| DISEASES 11152 \| WDR45 \| DISEASES 1778 \| DYNC1H1 \| DISEASES 23299 \| BICD2 \| DISEASES 3482 \| IGF2R \| DISEASES 10390 \| CEPT1 \| DISEASES 493 \| ATP2B4 \| DISEASES 871 \| SERPINH1 \| DISEASES 51530 \| ZC3HC1 \| DISEASES 51062 \| ATL1 \| DISEASES 7415 \| VCP \| DISEASES 7048 \| TGFBR2 \| DISEASES 617 \| BCS1L \| DISEASES 9197 \| SLC33A1 \| DISEASES 653440 \| WASH6P \| DISEASES 9895 \| TECPR2 \| DISEASES 1786 \| DNMT1 \| DISEASES 9179 \| AP4M1 \| DISEASES 773 \| CACNA1A \| DISEASES 4133 \| MAP2 \| DISEASES 1825 \| DSC3 \| DISEASES 4326 \| MMP17 \| DISEASES 26580 \| BSCL2 \| DISEASES 4976 \| OPA1 \| DISEASES 4535 \| MT-ND1 \| DISEASES 91252 \| SLC39A13 \| DISEASES 1639 \| DCTN1 \| DISEASES 2705 \| GJB1 \| DISEASES 8556 \| CDC14A \| DISEASES 79674 \| VEPH1 \| DISEASES 54583 \| EGLN1 \| DISEASES 200205 \| IBA57 \| DISEASES 57165 \| GJC2 \| DISEASES 5071 \| PARK2 \| DISEASES 3142 \| HLX \| DISEASES 7042 \| TGFB2 \| DISEASES 26750 \| RPS6KC1 \| DISEASES 84947 \| SERAC1 \| DISEASES 25778 \| DSTYK \| DISEASES 5788 \| PTPRC \| DISEASES 7827 \| NPHS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 1490 \| CTGF \| DISEASES 2117 \| ETV3 \| DISEASES 4580 \| MTX1 \| DISEASES 3713 \| IVL \| DISEASES 7062 \| TCHH \| DISEASES 10100 \| TSPAN2 \| DISEASES 10121 \| ACTR1A \| DISEASES 134728 \| IRAK1BP1 \| DISEASES 393 \| ARHGAP4 \| DISEASES 3897 \| L1CAM \| DISEASES 2334 \| AFF2 \| DISEASES 2635 \| GBP3 \| DISEASES 55361 \| PI4K2A \| DISEASES 5832 \| ALDH18A1 \| DISEASES 10555 \| AGPAT2 \| DISEASES 2060 \| EPS15 \| DISEASES 6836 \| SURF4 \| DISEASES 4318 \| MMP9 \| DISEASES 11128 \| POLR3A \| DISEASES 6709 \| SPTAN1 \| DISEASES 1678 \| TIMM8A \| DISEASES 27035 \| NOX1 \| DISEASES 27286 \| SRPX2 \| DISEASES 1104 \| RCC1 \| DISEASES 1741 \| DLG3 \| DISEASES 57185 \| NIPAL3 \| DISEASES 659 \| BMPR2 \| DISEASES 9314 \| KLF4 \| DISEASES 83737 \| ITCH \| DISEASES 80067 \| DCAF17 \| DISEASES 4958 \| OMD \| DISEASES 199 \| AIF1 \| DISEASES 84701 \| COX4I2 \| DISEASES 22921 \| MSRB2 \| DISEASES 26090 \| ABHD12 \| DISEASES 7454 \| WAS \| DISEASES 29907 \| SNX15 \| DISEASES 2395 \| FXN \| DISEASES 8869 \| ST3GAL5 \| DISEASES 6311 \| ATXN2 \| DISEASES 10970 \| CKAP4 \| DISEASES 57704 \| GBA2 \| DISEASES 10497 \| UNC13B \| DISEASES 55210 \| ATAD3A \| DISEASES 4868 \| NPHS1 \| DISEASES 64225 \| ATL2 \| DISEASES 4897 \| NRCAM \| DISEASES 55676 \| SLC30A6 \| DISEASES 7905 \| REEP5 \| DISEASES 10300 \| KATNB1 \| DISEASES 10631 \| POSTN \| DISEASES 54840 \| APTX \| DISEASES 203228 \| C9orf72 \| DISEASES 54875 \| CNTLN \| DISEASES 10528 \| NOP56 \| DISEASES 6547 \| SLC8A3 \| DISEASES 26278 \| SACS \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 1130 \| LYST \| DISEASES 8878 \| SQSTM1 \| DISEASES 11202 \| KLK8 \| DISEASES 147700 \| KLC3 \| DISEASES 4099 \| MAG \| DISEASES 83636 \| C19orf12 \| DISEASES 152137 \| CCDC50 \| DISEASES 55188 \| RIC8B \| DISEASES 4287 \| ATXN3 \| DISEASES 284076 \| TTLL6 \| DISEASES 1267 \| CNP \| DISEASES 11346 \| SYNPO \| DISEASES 10575 \| CCT4 \| DISEASES 285848 \| PNPLA1 \| DISEASES 64400 \| AKTIP \| DISEASES 6164 \| RPL34 \| DISEASES 3895 \| KTN1 \| DISEASES 2643 \| GCH1 \| DISEASES 6641 \| SNTB1 \| DISEASES 2919 \| CXCL1 \| DISEASES 6387 \| CXCL12 \| DISEASES 655 \| BMP7 \| DISEASES 6843 \| VAMP1 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 23259 \| DDHD2 \| DISEASES 7106 \| TSPAN4 \| DISEASES 283742 \| FAM98B \| DISEASES 51699 \| VPS29 \| DISEASES 5119 \| CHMP1A \| DISEASES 2687 \| GGT5 \| DISEASES 6314 \| ATXN7 \| DISEASES 2887 \| GRB10 \| DISEASES 25923 \| ATL3 \| DISEASES 6093 \| ROCK1 \| DISEASES 57680 \| CHD8 \| DISEASES 375775 \| PNPLA7 \| DISEASES 51571 \| FAM49B \| DISEASES 27247 \| NFU1 \| DISEASES 10989 \| IMMT \| DISEASES 285175 \| UNC80 \| DISEASES 3481 \| IGF2 \| DISEASES 55636 \| CHD7 \| DISEASES 8861 \| LDB1 \| DISEASES 3800 \| KIF5C \| DISEASES 279 \| AMY2A \| DISEASES 7124 \| TNF \| DISEASES 8605 \| PLA2G4C \| DISEASES 84529 \| C15orf41 \| DISEASES 10908 \| PNPLA6 \| DISEASES 3798 \| KIF5A \| DISEASES 2632 \| GBE1 \| DISEASES 1028 \| CDKN1C \| DISEASES 22862 \| FNDC3A \| DISEASES 23089 \| PEG10 \| DISEASES 10243 \| GPHN \| DISEASES 1496 \| CTNNA2 \| DISEASES 57113 \| TRPC7 \| DISEASES 23303 \| KIF13B \| DISEASES 23025 \| UNC13A \| DISEASES 9791 \| PTDSS1 \| DISEASES 123041 \| SLC24A4 \| DISEASES 57558 \| USP35 \| DISEASES 57132 \| CHMP1B \| DISEASES 3748 \| KCNC3 \| DISEASES 9152 \| SLC6A5 \| DISEASES 388015 \| RTL1 \| DISEASES 6195 \| RPS6KA1 \| DISEASES 9973 \| CCS \| DISEASES 65055 \| REEP1 \| DISEASES 192111 \| PGAM5 \| DISEASES 785 \| CACNB4 \| DISEASES 283446 \| MYO1H \| DISEASES 4090 \| SMAD5 \| DISEASES 83857 \| TMTC1 \| DISEASES 8437 \| RASAL1 \| DISEASES 9990 \| SLC12A6 \| DISEASES 4212 \| MEIS2 \| DISEASES 91056 \| AP5B1 \| DISEASES 57733 \| GBA3 \| DISEASES 149775 \| GNAS-AS1 \| DISEASES 102723508 \| KANTR \| DISEASES 10984 \| KCNQ1OT1 \| DISEASES 55384 \| MEG3 \| DISEASES 317751 \| MESTIT1 \| DISEASES 26801 \| SNORD48 \| DISEASES
Locus	(Waiting for update.)

Disease ID	430
Disease	paraplegia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:74) HP:0002079 \| Hypoplasia of the corpus callosum \| 19 HP:0003690 \| Limb weakness \| 8 HP:0001249 \| Mental retardation \| 7 HP:0012531 \| Pain \| 7 HP:0001251 \| Ataxia \| 5 HP:0012486 \| Inflammation of spinal cord \| 4 HP:0003477 \| Peripheral axonal neuropathy \| 4 HP:0001284 \| Areflexia \| 3 HP:0100310 \| Extradural hematoma \| 3 HP:0000648 \| Optic-nerve degeneration \| 3 HP:0001265 \| Decreased tendon reflexes \| 2 HP:0040078 \| Axonal degeneration \| 2 HP:0012399 \| Bedsore \| 2 HP:0002176 \| Spinal cord compression \| 2 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 2 HP:0004942 \| Aortic aneurysm \| 2 HP:0009830 \| Peripheral neuritis \| 2 HP:0030731 \| Carcinoma \| 2 HP:0001288 \| Gait disturbance \| 2 HP:0004947 \| Arteriovenous fistula \| 2 HP:0001257 \| Spasticity \| 2 HP:0001268 \| Mental deterioration \| 2 HP:0003474 \| Sensory impairment \| 2 HP:0001263 \| Developmental retardation \| 2 HP:0001945 \| Fever \| 2 HP:0000016 \| Urinary retention \| 1 HP:0003487 \| Extensor plantar reflexes \| 1 HP:0000969 \| Dropsy \| 1 HP:0007002 \| Motor axonal neuropathy \| 1 HP:0001260 \| Dysarthric speech \| 1 HP:0003470 \| Inability to move \| 1 HP:0001028 \| Strawberry mark \| 1 HP:0000822 \| Hypertension \| 1 HP:0030834 \| Shoulder pain \| 1 HP:0100561 \| Spinal cord lesion \| 1 HP:0000519 \| Cataracts, lenticular, bilateral \| 1 HP:0005881 \| Spinal instability \| 1 HP:0002808 \| Gibbus deformity \| 1 HP:0001252 \| Hypotonia \| 1 HP:0100242 \| Sarcoma \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0002196 \| Myelopathy \| 1 HP:0000639 \| Nystagmus \| 1 HP:0002607 \| Anal incontinence \| 1 HP:0003416 \| Spinal canal stenosis \| 1 HP:0000763 \| Sensory neuropathy \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0002277 \| Horner's syndrome \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0004953 \| Abdominal aortic aneurysm \| 1 HP:0001548 \| Overgrowth \| 1 HP:0009058 \| Muscle lipidosis \| 1 HP:0001004 \| Lymphatic obstruction \| 1 HP:0200040 \| Epidermal inclusion cyst \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0003401 \| Paresthesia \| 1 HP:0002385 \| Paraparesis \| 1 HP:0007178 \| Motor polyneuropathy \| 1 HP:0001337 \| Tremor \| 1 HP:0000518 \| Cataract \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0002600 \| Hyporeflexia of lower limbs \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0001997 \| Gout \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0000726 \| Dementia \| 1 HP:0002839 \| Urinary bladder sphincter dysfunction \| 1 HP:0003390 \| Sensory axonal neuropathy \| 1 HP:0001297 \| Cerebral vascular events \| 1

Disease ID	430
Disease	paraplegia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:66) C2707258 \| infections C2678504 \| osteoporosis C2598155 \| pain C1963244 \| supraventricular tachycardia C1963087 \| constipation C1961100 \| erectile dysfunction C1546602 \| diverticulum C1540912 \| hypereosinophilic syndrome C1258215 \| ileus C1000483 \| anemia C0700208 \| scoliosis C0699885 \| bladder cancer C0694550 \| recurrent pneumonia C0600139 \| carcinoma of the prostate C0575081 \| gait disturbance C0494752 \| diaphragmatic hernia C0452221 \| vertebral osteomyelitis C0451641 \| urolithiasis C0426768 \| o sign C0423716 \| neuropathic pain C0401149 \| chronic constipation C0392525 \| nephrolithiasis C0271708 \| fasting hypoglycemia C0270777 \| spinal cord edema C0263661 \| osteoarthropathies C0235031 \| neurologic symptoms C0221166 \| paraparesis C0152256 \| disuse osteoporosis C0085697 \| chronic pyelonephritis C0042580 \| vesicoureteral reflux C0042580 \| vesico-ureteric reflux C0042580 \| vesico-ureteral reflux C0042075 \| urinary tract disorders C0042029 \| urinary infection C0039070 \| syncope C0038828 \| superior mesenteric artery syndrome C0038525 \| subarachnoid hemorrhage C0037763 \| spasms C0037315 \| sleep apnoea C0037299 \| skin ulceration C0034216 \| pyonephrosis C0034186 \| pyelonephritis C0034065 \| pulmonary embolism C0033117 \| priapism C0030925 \| perforated peptic ulcer C0030920 \| peptic ulcer C0029440 \| osteoma C0027122 \| myositis ossificans C0026838 \| spasticity C0026826 \| hypertonia C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0022408 \| arthropathies C0020903 \| illusions C0020440 \| hypercapnia C0020295 \| hydronephrosis C0016053 \| fibromyositis C0012616 \| disarticulation C0011127 \| pressure sores C0011127 \| decubitus ulcers C0011127 \| decubitus ulcer C0011127 \| bedsores C0010701 \| cystosarcoma phyllodes C0009024 \| clonus C0002726 \| amyloidosis C0001080 \| chondrodystrophia fetalis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0030193 \| pain \| 7 C0426768 \| o sign \| 2 C0575081 \| gait disturbance \| 2 C0026838 \| spasticity \| 2 C0011127 \| pressure sores \| 2 C0221166 \| paraparesis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0030486	betamethasone	D001623	378-44-9	paraplegia	MESH:D010264	marker/mechanism	19863744
C0030486	bupivacaine	D002045	2180-92-9	paraplegia	MESH:D010264	marker/mechanism	21030892
C0030486	butorphanol	D002077	42408-82-2	paraplegia	MESH:D010264	marker/mechanism	21030892
C0030486	methotrexate	D008727	1959/5/2	paraplegia	MESH:D010264	marker/mechanism	2023567
C0030486	mitoxantrone	D008942	65271-80-9	paraplegia	MESH:D010264	marker/mechanism	2878247
C0030486	nelarabine	C104457	-	paraplegia	MESH:D010264	marker/mechanism	20658590
C0030486	thiotepa	D013852	52-24-4	paraplegia	MESH:D010264	marker/mechanism	8711459
C0030486	vincristine	D014750	-	paraplegia	MESH:D010264	therapeutic	9375755

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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