PedAM

Pediatric Disease Annotations & Medicines


	panuveitis

Disease ID	613
Disease	panuveitis
Definition	Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.
Synonym	diffuse uveitis panuveitis (disorder) panuveitis [disease/finding]
Orphanet	ORPHANET:280898
DOID	DOID:12030
UMLS	C0030343
MeSH	D015864
SNOMED-CT	SNOMEDCT_US_2016_09_01:75614007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:35) C0035305 \| retinal detachment \| 12 C0008526 \| choroiditis \| 8 C0035305 \| retinal detachments \| 5 C0042384 \| vasculitis \| 4 C0017601 \| glaucoma \| 4 C0042900 \| vitiligo \| 3 C0271051 \| macular edema \| 2 C0035333 \| retinitis \| 2 C0152026 \| retinal vasculitis \| 2 C0042164 \| uveitis \| 2 C0002170 \| alopecia \| 2 C0003873 \| rheumatoid arthritis \| 2 C0086543 \| cataract \| 2 C0238463 \| papillary thyroid carcinoma \| 1 C0015397 \| ocular disease \| 1 C0042769 \| virus infection \| 1 C0023788 \| whipple disease \| 1 C0008513 \| retinochoroiditis \| 1 C0022073 \| iridocyclitis \| 1 C0549473 \| thyroid carcinoma \| 1 C0456909 \| blindness \| 1 C0007115 \| thyroid ca \| 1 C0035435 \| rheumatic diseases \| 1 C0035435 \| rheumatic disease \| 1 C0039128 \| syphilis \| 1 C0035328 \| retinal vein occlusion \| 1 C0024441 \| macular hole \| 1 C0035309 \| retinal disease \| 1 C0036202 \| sarcoidosis \| 1 C0024440 \| cystoid macular edema \| 1 C0008513 \| chorioretinitis \| 1 C0042167 \| posterior uveitis \| 1 C0042164 \| intraocular inflammation \| 1 C0162293 \| papillitis \| 1 C0949691 \| spondyloarthropathy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:155) 7132 \| TNFRSF1A \| DISEASES 5442 \| POLRMT \| DISEASES 4282 \| MIF \| DISEASES 1414 \| CRYBB1 \| DISEASES 3560 \| IL2RB \| DISEASES 2137 \| EXTL3 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 7991 \| TUSC3 \| DISEASES 973 \| CD79A \| DISEASES 5949 \| RBP3 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 3111 \| HLA-DOA \| DISEASES 3565 \| IL4 \| DISEASES 8809 \| IL18R1 \| DISEASES 6402 \| SELL \| DISEASES 7128 \| TNFAIP3 \| DISEASES 10804 \| GJB6 \| DISEASES 6431 \| SRSF6 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 1401 \| CRP \| DISEASES 1823 \| DSC1 \| DISEASES 80210 \| ARMC9 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 27348 \| TOR1B \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 7188 \| TRAF5 \| DISEASES 23406 \| COTL1 \| DISEASES 898 \| CCNE1 \| DISEASES 10133 \| OPTN \| DISEASES 443 \| ASPA \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 10994 \| ILVBL \| DISEASES 55717 \| WDR11 \| DISEASES 832 \| CAPZB \| DISEASES 941 \| CD80 \| DISEASES 8808 \| IL1RL2 \| DISEASES 84162 \| KIAA1109 \| DISEASES 3383 \| ICAM1 \| DISEASES 3189 \| HNRNPH3 \| DISEASES 6687 \| SPG7 \| DISEASES 57410 \| SCYL1 \| DISEASES 9869 \| SETDB1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 4715 \| NDUFB9 \| DISEASES 3439 \| IFNA1 \| DISEASES 726 \| CAPN5 \| DISEASES 23643 \| LY96 \| DISEASES 1636 \| ACE \| DISEASES 1409 \| CRYAA \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 1584 \| CYP11B1 \| DISEASES 85451 \| UNK \| DISEASES 6352 \| CCL5 \| DISEASES 3577 \| CXCR1 \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 51752 \| ERAP1 \| DISEASES 4714 \| NDUFB8 \| DISEASES 64127 \| NOD2 \| DISEASES 56947 \| MFF \| DISEASES 1493 \| CTLA4 \| DISEASES 9655 \| SOCS5 \| DISEASES 3627 \| CXCL10 \| DISEASES 56246 \| MRAP \| DISEASES 81793 \| TLR10 \| DISEASES 5340 \| PLG \| DISEASES 5553 \| PRG2 \| DISEASES 767 \| CA8 \| DISEASES 55075 \| UACA \| DISEASES 4684 \| NCAM1 \| DISEASES 149233 \| IL23R \| DISEASES 342898 \| SYCN \| DISEASES 23046 \| KIF21B \| DISEASES 125061 \| AFMID \| DISEASES 8651 \| SOCS1 \| DISEASES 81565 \| NDEL1 \| DISEASES 5133 \| PDCD1 \| DISEASES 57153 \| SLC44A2 \| DISEASES 114548 \| NLRP3 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 966 \| CD59 \| DISEASES 84639 \| IL1F10 \| DISEASES 6731 \| SRP72 \| DISEASES 3605 \| IL17A \| DISEASES 766 \| CA7 \| DISEASES 23111 \| SPG20 \| DISEASES 100506658 \| OCLN \| DISEASES 50488 \| MINK1 \| DISEASES 1717 \| DHCR7 \| DISEASES 5265 \| SERPINA1 \| DISEASES 9600 \| PITPNM1 \| DISEASES 6775 \| STAT4 \| DISEASES 9652 \| TTC37 \| DISEASES 9332 \| CD163 \| DISEASES 26191 \| PTPN22 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 676 \| BRDT \| DISEASES 7096 \| TLR1 \| DISEASES 6993 \| DYNLT1 \| DISEASES 3080 \| CFHR2 \| DISEASES 3075 \| CFH \| DISEASES 356 \| FASLG \| DISEASES 4942 \| OAT \| DISEASES 8804 \| CREG1 \| DISEASES 959 \| CD40LG \| DISEASES 5737 \| PTGFR \| DISEASES 7422 \| VEGFA \| DISEASES 55315 \| SLC29A3 \| DISEASES 5464 \| PPA1 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 1896 \| EDA \| DISEASES 5698 \| PSMB9 \| DISEASES 50943 \| FOXP3 \| DISEASES 100507436 \| MICA \| DISEASES 3107 \| HLA-C \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 8718 \| TNFRSF25 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 3559 \| IL2RA \| DISEASES 4155 \| MBP \| DISEASES 3426 \| CFI \| DISEASES 7913 \| DEK \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 337867 \| UBAC2 \| DISEASES 3778 \| KCNMA1 \| DISEASES 6295 \| SAG \| DISEASES 3550 \| IK \| DISEASES 720 \| C4A \| DISEASES 55683 \| KANSL3 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 64167 \| ERAP2 \| DISEASES 4049 \| LTA \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 6171 \| RPL41 \| DISEASES 7710 \| ZNF154 \| DISEASES 51428 \| DDX41 \| DISEASES 346007 \| EYS \| DISEASES 11331 \| PHB2 \| DISEASES 567 \| B2M \| DISEASES 79104 \| MEG8 \| DISEASES 100130889 \| PSORS1C3 \| DISEASES
Locus	(Waiting for update.)

Disease ID	613
Disease	panuveitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0000541 \| Detached retina \| 11 HP:0012123 \| Posterior uveitis \| 9 HP:0012231 \| Exudative retinal detachment \| 6 HP:0002633 \| Vasculitis \| 4 HP:0001045 \| Blotchy loss of skin color \| 3 HP:0002290 \| Poliosis \| 3 HP:0002721 \| Immunodeficiency \| 2 HP:0000969 \| Dropsy \| 2 HP:0040049 \| Macular edema \| 2 HP:0000554 \| Uveitis \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0001596 \| Hair loss \| 2 HP:0000501 \| Glaucoma \| 2 HP:0002890 \| Thyroid carcinoma \| 1 HP:0000572 \| Visual loss \| 1 HP:0001094 \| Iridocyclitis \| 1 HP:0000618 \| Blindness \| 1 HP:0009926 \| Epiphora \| 1 HP:0000518 \| Cataract \| 1 HP:0012230 \| Rhegmatogenous retinal detachment \| 1 HP:0011508 \| Macular hole \| 1 HP:0012636 \| Retinal vein occlusion \| 1 HP:0012531 \| Pain \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0008052 \| Retinal fold \| 1 HP:0200026 \| Ocular pain \| 1 HP:0000613 \| Extreme light sensitivity \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0007866 \| Retinal infarction \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1

Disease ID	613
Disease	panuveitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C2364133 \| infection C1843274 \| acute tubulointerstitial nephritis C1328519 \| retinal pigment epithelial tear C0151827 \| ocular pain C0042170 \| vogt-koyanagi-harada syndrome C0035321 \| retinal tears
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061170	23497844	3075	CFH	umls:C0030343	BeFree	Carriage of the CFH Y402H polymorphism in both alleles is associated with an increased risk for posterior uveitis and panuveitis presentation.	0.000271442	2013	CFH	1	196690107	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0030343	rifabutin	D017828	72559-06-9	panuveitis	MESH:D015864	marker/mechanism	16321897

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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