PedAM

Pediatric Disease Annotations & Medicines


	pain disorder

Disease ID	1410
Disease	pain disorder
Definition	Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused by psychological stress. The pain is often so severe that it disables the patient from proper functioning. Duration may be as short as a few days or as long as many years. The disorder may begin at any age, and occurs more frequently in girls than boys.[1] This disorder often occurs after an accident or during an illness that has caused pain, which then takes on a 'life' of its own.[2] - Wikipedia Reference: https://en.wikipedia.org/wiki/pain disorder
Synonym	disorder pain disorders pain pain dis pain disorders pain syndrome pain syndromes syndrome pain
DOID	DOID:0060164
UMLS	C0391976
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0011570 \| depression \| 6 C0003467 \| anxiety \| 5 C0028754 \| obesity \| 3 C0282488 \| interstitial cystitis \| 1 C0442874 \| neuropathy \| 1 C0037317 \| sleep disturbances \| 1 C0037650 \| somatoform disorders \| 1 C0020604 \| hypochondriasis \| 1 C0037317 \| sleep disturbance \| 1 C0002766 \| analgesia \| 1 C0014544 \| epilepsy \| 1 C0011251 \| delusional disorder \| 1 C0037650 \| somatoform disorder \| 1 C0031117 \| peripheral neuropathies \| 1 C0016053 \| fibromyalgia syndrome \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:188) 100126791 \| EGOT \| DISEASES 22846 \| VASH1 \| DISEASES 9741 \| LAPTM4A \| DISEASES 7380 \| UPK3A \| DISEASES 5173 \| PDYN \| DISEASES 479 \| ATP12A \| DISEASES 4210 \| MEFV \| DISEASES 51200 \| CPA4 \| DISEASES 6348 \| CCL3 \| DISEASES 5023 \| P2RX1 \| DISEASES 6347 \| CCL2 \| DISEASES 2784 \| GNB3 \| DISEASES 10279 \| PRSS16 \| DISEASES 1839 \| HBEGF \| DISEASES 3565 \| IL4 \| DISEASES 7035 \| TFPI \| DISEASES 80306 \| MED28 \| DISEASES 103910 \| MYL12B \| DISEASES 3070 \| HELLS \| DISEASES 9496 \| TBX4 \| DISEASES 2693 \| GHSR \| DISEASES 4852 \| NPY \| DISEASES 92797 \| HELB \| DISEASES 7429 \| VIL1 \| DISEASES 7166 \| TPH1 \| DISEASES 1215 \| CMA1 \| DISEASES 15 \| AANAT \| DISEASES 8220 \| DGCR14 \| DISEASES 9997 \| SCO2 \| DISEASES 2670 \| GFAP \| DISEASES 10267 \| RAMP1 \| DISEASES 23135 \| KDM6B \| DISEASES 1401 \| CRP \| DISEASES 78986 \| DUSP26 \| DISEASES 3569 \| IL6 \| DISEASES 2615 \| LRRC32 \| DISEASES 64398 \| MPP5 \| DISEASES 6532 \| SLC6A4 \| DISEASES 999 \| CDH1 \| DISEASES 8989 \| TRPA1 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 1326 \| MAP3K8 \| DISEASES 23523 \| CABIN1 \| DISEASES 5024 \| P2RX3 \| DISEASES 3553 \| IL1B \| DISEASES 9424 \| KCNK6 \| DISEASES 7379 \| UPK2 \| DISEASES 7348 \| UPK1B \| DISEASES 5443 \| POMC \| DISEASES 3827 \| KNG1 \| DISEASES 286 \| ANK1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 57332 \| CBX8 \| DISEASES 150094 \| SIK1 \| DISEASES 3358 \| HTR2C \| DISEASES 55327 \| LIN7C \| DISEASES 6506 \| SLC1A2 \| DISEASES 10398 \| MYL9 \| DISEASES 51348 \| KLRF1 \| DISEASES 2904 \| GRIN2B \| DISEASES 150 \| ADRA2A \| DISEASES 8562 \| DENR \| DISEASES 7082 \| TJP1 \| DISEASES 2911 \| GRM1 \| DISEASES 23576 \| DDAH1 \| DISEASES 7345 \| UCHL1 \| DISEASES 5651 \| TMPRSS15 \| DISEASES 10563 \| CXCL13 \| DISEASES 4489 \| MT1A \| DISEASES 90525 \| SHF \| DISEASES 8209 \| C21orf33 \| DISEASES 729230 \| CCR2 \| DISEASES 72 \| ACTG2 \| DISEASES 886 \| CCKAR \| DISEASES 64320 \| RNF25 \| DISEASES 1359 \| CPA3 \| DISEASES 57159 \| TRIM54 \| DISEASES 6228 \| RPS23 \| DISEASES 168667 \| BMPER \| DISEASES 9311 \| ASIC3 \| DISEASES 6571 \| SLC18A2 \| DISEASES 915 \| CD3D \| DISEASES 143501 \| C11orf40 \| DISEASES 6870 \| TACR3 \| DISEASES 6869 \| TACR1 \| DISEASES 2915 \| GRM5 \| DISEASES 3575 \| IL7R \| DISEASES 2353 \| FOS \| DISEASES 1473 \| CST5 \| DISEASES 11280 \| SCN11A \| DISEASES 27289 \| RND1 \| DISEASES 660 \| BMX \| DISEASES 51316 \| PLAC8 \| DISEASES 55215 \| FANCI \| DISEASES 354 \| KLK3 \| DISEASES 9377 \| COX5A \| DISEASES 8575 \| PRKRA \| DISEASES 27319 \| BHLHE22 \| DISEASES 6863 \| TAC1 \| DISEASES 3157 \| HMGCS1 \| DISEASES 55 \| ACPP \| DISEASES 79054 \| TRPM8 \| DISEASES 5179 \| PENK \| DISEASES 29895 \| MYLPF \| DISEASES 286826 \| LIN9 \| DISEASES 2903 \| GRIN2A \| DISEASES 8912 \| CACNA1H \| DISEASES 338567 \| KCNK18 \| DISEASES 51738 \| GHRL \| DISEASES 5025 \| P2RX4 \| DISEASES 4987 \| OPRL1 \| DISEASES 1982 \| EIF4G2 \| DISEASES 80320 \| SP6 \| DISEASES 132884 \| EVC2 \| DISEASES 22953 \| P2RX2 \| DISEASES 23463 \| ICMT \| DISEASES 11276 \| SYNRG \| DISEASES 1809 \| DPYSL3 \| DISEASES 3605 \| IL17A \| DISEASES 467 \| ATF3 \| DISEASES 94134 \| ARHGAP12 \| DISEASES 6334 \| SCN8A \| DISEASES 309 \| ANXA6 \| DISEASES 954 \| ENTPD2 \| DISEASES 3359 \| HTR3A \| DISEASES 55010 \| PARPBP \| DISEASES 4149 \| MAX \| DISEASES 3635 \| INPP5D \| DISEASES 1312 \| COMT \| DISEASES 388677 \| NOTCH2NL \| DISEASES 9937 \| DCLRE1A \| DISEASES 23038 \| WDTC1 \| DISEASES 10223 \| GPA33 \| DISEASES 284486 \| THEM5 \| DISEASES 5654 \| HTRA1 \| DISEASES 5550 \| PREP \| DISEASES 4803 \| NGF \| DISEASES 282991 \| BLOC1S2 \| DISEASES 1369 \| CPN1 \| DISEASES 54558 \| SPATA6 \| DISEASES 6406 \| SEMG1 \| DISEASES 1025 \| CDK9 \| DISEASES 6865 \| TACR2 \| DISEASES 7099 \| TLR4 \| DISEASES 8325 \| FZD8 \| DISEASES 199 \| AIF1 \| DISEASES 50943 \| FOXP3 \| DISEASES 146 \| ADRA1D \| DISEASES 22944 \| KIN \| DISEASES 114131 \| UCN3 \| DISEASES 148 \| ADRA1A \| DISEASES 56897 \| WRNIP1 \| DISEASES 438 \| ASMT \| DISEASES 9467 \| SH3BP5 \| DISEASES 340152 \| ZC3H12D \| DISEASES 51429 \| SNX9 \| DISEASES 654364 \| NME1-NME2 \| DISEASES 2962 \| GTF2F1 \| DISEASES 7041 \| TGFB1I1 \| DISEASES 100131390 \| SP9 \| DISEASES 3895 \| KTN1 \| DISEASES 27297 \| CRCP \| DISEASES 594857 \| NPS \| DISEASES 7110 \| TMF1 \| DISEASES 10606 \| PAICS \| DISEASES 7442 \| TRPV1 \| DISEASES 6335 \| SCN9A \| DISEASES 4295 \| MLN \| DISEASES 6336 \| SCN10A \| DISEASES 4988 \| OPRM1 \| DISEASES 4908 \| NTF3 \| DISEASES 7124 \| TNF \| DISEASES 139728 \| PNCK \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 346007 \| EYS \| DISEASES 4914 \| NTRK1 \| DISEASES 9152 \| SLC6A5 \| DISEASES 10978 \| CLP1 \| DISEASES 4190 \| MDH1 \| DISEASES 51271 \| UBAP1 \| DISEASES 8972 \| MGAM \| DISEASES 9051 \| PSTPIP1 \| DISEASES 91056 \| AP5B1 \| DISEASES 820 \| CAMP \| DISEASES 26085 \| KLK13 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1410
Disease	pain disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0012532 \| Chronic pain \| 20 HP:0012531 \| Pain \| 13 HP:0000716 \| Depression \| 6 HP:0000739 \| Anxiety \| 5 HP:0012533 \| Allodynia \| 3 HP:0003418 \| Back pain \| 3 HP:0001513 \| Obesity \| 3 HP:0003419 \| Low back pain \| 2 HP:0030833 \| Neck pain \| 2 HP:0006824 \| Cranial nerve palsy \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0012378 \| Fatigue \| 1 HP:0200025 \| Mandibular pain \| 1 HP:0002360 \| Sleep disturbance \| 1

Disease ID	1410
Disease	pain disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs375828897	25116815	6335	SCN9A	umls:C0391976	BeFree	Genetic testing for ion channel-associated pain disorders revealed an amino acid R1150W substitution of the Nav1.7 sodium channel.	0.005971721	2014	SCN9A;LOC101929680	2	166242645	T	A
rs398123010	24564660	8989	TRPA1	umls:C0391976	BeFree	Remarkably, a substitution of single amino acid in the S4-S5 region of TRPA1 (N855S) has been recently associated with familial episodic pain syndrome.	0.001357209	2014	TRPA1;LOC100132891	8	72034369	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:4)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	96145968	rs6693882	A	G	rs6693882	19207018	2.00E-06	post-operative pain onset time	NA	NA	60 females; 52 males	NOPOP(112)	ALL(112)	NOPOP(112)	ALL(112)	Pain	HPOID:0009763	Limb pain	DOID:0060164	pain disorder	D010146	Pain	EFOID:0003843	pain	Psychotic disorder	NA	Research Support, N.I.H., Intramural	A	NA
5	10169823	rs13361160	T	C	rs13361160	22956598	5.00E-07	NA	1.17	[1.10-1.24]	1,308 female European ancestry cases; 5,791 female European ancestry controls	European(7099)	ALL(7099)	EUR(7099)	ALL(7099)	Pain	HPOID:0009763	Limb pain	DOID:0060164	pain disorder	D010146	Pain	EFOID:0003843	pain	Psychotic disorder	rs13361160-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
11	118145686	rs17122021	C	T	rs17122021	19207018	7.00E-07	maximum post-operative pain rating	NA	NA	60 females; 52 males	NOPOP(112)	ALL(112)	NOPOP(112)	ALL(112)	Pain	HPOID:0009763	Limb pain	DOID:0060164	pain disorder	D010146	Pain	EFOID:0003843	pain	Psychotic disorder	NA	Research Support, N.I.H., Intramural	T,C	NA
19	21666210	rs2562456	C	T	rs2562456	19207018	2.00E-10	onset time of analgesia	NA	NA	60 females; 52 males	NOPOP(112)	ALL(112)	NOPOP(112)	ALL(112)	Pain	HPOID:0009763	Limb pain	DOID:0060164	pain disorder	D010146	Pain	EFOID:0003843	pain	Psychotic disorder	NA	Research Support, N.I.H., Intramural	A	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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