PedAM
Pediatric Disease Annotations & Medicines
| otitis media | ||||
| Disease ID | 734 |
|---|---|
| Disease | otitis media |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:21) C1384666 | hearing loss | 49 C0008373 | cholesteatoma | 48 C0018777 | conductive hearing loss | 16 C0009450 | infection | 12 C0032285 | pneumoniae | 11 C0018784 | sensorineural hearing loss | 9 C0021400 | influenzae | 8 C0025289 | meningitis | 7 C0029883 | middle ear effusion | 6 C0015464 | facial palsy | 5 C0018483 | haemophilus influenzae | 5 C0015469 | facial nerve paralysis | 4 C0015469 | facial paralysis | 4 C0018188 | granuloma | 2 C0017168 | esophageal reflux | 2 C0006105 | brain abscess | 2 C0270639 | lateral sinus thrombosis | 1 C0154639 | streptococcal meningitis | 1 C0004610 | bacteremia | 1 C0002111 | allergy | 1 C0426768 | o sign | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:51) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 1 | 3691727 | rs1175549 | A | C | rs1175549 | 23133572 | 0.0000265 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 1 | 26746807 | rs12728900 | G | A | rs12728900 | 23133572 | 0.0000228 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31296644 | rs2098787 | A | G | rs2098787 | 23133572 | 0.00000726 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31297524 | rs1862981 | T | G | rs1862981 | 23133572 | 0.0000051 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31415054 | rs17010928 | G | A | rs17010928 | 23133572 | 0.0000985 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31431651 | rs6728152 | T | C | rs6728152 | 23133572 | 0.000175 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31444826 | rs13408922 | C | A | rs13408922 | 23133572 | 0.00000132 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31445615 | rs13386745 | A | G | rs13386745 | 23133572 | 0.00000163 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 31445691 | rs13386850 | A | C | rs13386850 | 23133572 | 0.00000132 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 48041377 | rs330787 | A | G | rs330787 | 23133572 | 0.0000464 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 2 | 174297659 | rs10497394 | C | T | rs10497394 | 23974705 | 2.00E-08 | NA | 1.51 | [1.30-1.70] | 373 cases; 229 controls from 143 families | NOPOP(602) | ALL(602) | NOPOP(602) | ALL(602) | Otitis media (chronic/recurrent) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | rs10497394-G | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 3 | 61620466 | rs17624623 | T | C | rs17624623 | 23133572 | 0.0000202 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 4 | 94583840 | rs11097383 | T | C | rs11097383 | 23133572 | 0.0000597 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 4 | 106005247 | rs10008015 | C | T | rs10008015 | 23133572 | 0.0000389 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 4 | 106042692 | rs1859161 | C | T | rs1859161 | 23133572 | 0.000019 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 4 | 186790909 | rs11940126 | G | A | rs11940126 | 23133572 | 0.000057 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 5 | 685748 | rs386057 | G | A | rs386057 | 23974705 | 6.94E-05 | NA | 1.35 | [1.20-1.60] | 373 cases; 229 controls from 143 families | NOPOP(602) | ALL(602) | NOPOP(602) | ALL(602) | Otitis media (chronic/recurrent) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | rs386057-G | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 7 | 90259912 | rs10242197 | C | T | rs10242197 | 23133572 | 0.0000423 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 7 | 90656040 | rs10488001 | G | T | rs10488001 | 23133572 | 0.0000453 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 50540708 | rs1496306 | T | C | rs1496306 | 23133572 | 0.0000163 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 50605655 | rs2132528 | T | C | rs2132528 | 23133572 | 0.0000241 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 62525896 | rs2882460 | C | A | rs2882460 | 23133572 | 0.0000496 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 62566832 | rs6471969 | G | T | rs6471969 | 23133572 | 0.00000373 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 62584995 | rs11990408 | A | G | rs11990408 | 23133572 | 0.000011 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 62620839 | rs11787089 | C | T | rs11787089 | 23133572 | 0.00000454 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 87858778 | rs13438948 | G | A | rs13438948 | 23133572 | 0.0000119 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 130370235 | rs7846284 | A | G | rs7846284 | 23133572 | 0.0000406 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 8 | 130370414 | rs7846684 | C | T | rs7846684 | 23133572 | 0.000036 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 9 | 94588498 | rs11790808 | T | C | rs11790808 | 23133572 | 0.0000115 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 9 | 138718121 | rs10776851 | A | G | rs10776851 | 23133572 | 0.0000213 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 10 | 20279158 | rs16919668 | A | G | rs16919668 | 23133572 | 0.0000205 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 10 | 53425328 | rs4575213 | C | A | rs4575213 | 23133572 | 0.0000465 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 10 | 106531703 | rs10884043 | A | G | rs10884043 | 23133572 | 0.0000274 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 10 | 106558025 | rs4556466 | A | G | rs4556466 | 23133572 | 0.0000247 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 13 | 72912338 | rs9564897 | G | T | rs9564897 | 23133572 | 0.0000198 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 13 | 102965003 | rs1336708 | A | G | rs1336708 | 23133572 | 0.0000331 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 13 | 111082058 | rs4512966 | T | C | rs4512966 | 23133572 | 0.0000252 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 15 | 58292636 | rs6493973 | T | C | rs6493973 | 23133572 | 0.000044 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 15 | 58294022 | rs2218261 | T | C | rs2218261 | 23133572 | 0.000044 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 15 | 58328448 | rs2704219 | T | C | rs2704219 | 23133572 | 0.0000372 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 15 | 90126121 | rs10775247 | C | T | rs10775247 | 23974705 | 3.00E-04 | NA | 0.77 | [0.67-0.89] | 373 cases; 229 controls from 143 families | NOPOP(602) | ALL(602) | NOPOP(602) | ALL(602) | Otitis media (chronic/recurrent) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | rs10775247-C | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 15 | 90190048 | rs1110060 | A | G | rs1110060 | 23974705 | 4.09E-05 | NA | 0.74 | [0.64-0.85] | 373 cases; 229 controls from 143 families | NOPOP(602) | ALL(602) | NOPOP(602) | ALL(602) | Otitis media (chronic/recurrent) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | rs1110060-A | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 17 | 78524244 | rs4627412 | G | A | rs4627412 | 23133572 | 0.0000463 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 17 | 78524407 | rs9911978 | G | A | rs9911978 | 23133572 | 0.0000463 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 20 | 31790377 | rs17396317 | G | A | rs17396317 | 23133572 | 0.0000515 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 20 | 31806588 | rs17305657 | T | C | rs17305657 | 23133572 | 0.0000328 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 20 | 31812923 | rs3818222 | G | A | rs3818222 | 23133572 | 0.0000328 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 20 | 31817604 | rs6059169 | A | C | rs6059169 | 23133572 | 0.000233 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 20 | 31826027 | rs6059183 | T | C | rs6059183 | 23133572 | 0.000301 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| 21 | 43869663 | rs2839520 | G | A | rs2839520 | 23133572 | 0.0000163 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
| X | 124133621 | rs1894516 | G | A | rs1894516 | 23133572 | 0.00000664 | NA | NA | NA | 416 cases; 1,075 controls of European | NOPOP(416) | European(1075) | ALL(1491) | NOPOP(416) | EUR(1075) | ALL(1491) | Otitis media (children 3 years old or younger) | HPOID:0000388 | Otitis media | DOID:10754 | otitis media | NA | NA | NA | NA | Otitis media | NA | Research Support, Non-U.S. Gov't |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:5) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0029882 | azithromycin | D017963 | 83905-01-5 | otitis media | MESH:D010033 | therapeutic | 16117986 | ||
| C0029882 | cefdinir | C056814 | - | otitis media | MESH:D010033 | therapeutic | 16117986 | ||
| C0029882 | ciprofloxacin | D002939 | 85721-33-1 | otitis media | MESH:D010033 | therapeutic | 12670280 | ||
| C0029882 | methadone | D008691 | 76-99-3 | otitis media | MESH:D010033 | marker/mechanism | 6178811 | ||
| C0029882 | phenylpropanolamine | D010665 | 14838-15-4 | otitis media | MESH:D010033 | therapeutic | 92706 | ||
FDA approved drug and dosage information(Total Drugs:2) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D010033 | cipro | ciprofloxacin | 400MG/40ML (10MG/ML) | INJECTABLE;INJECTION | Discontinued | None | Yes | No |
| MESH:D010033 | cipro | ciprofloxacin | 250MG/5ML | FOR SUSPENSION;ORAL | Prescription | AB | Yes | No |
FDA labeling changes(Total Drugs:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D010033 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |
| MESH:D010033 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |