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Pediatric Disease Annotations & Medicines



   osteonecrosis
  

Disease ID 541
Disease osteonecrosis
Definition
Death of a bone or part of a bone, either atraumatic or posttraumatic.
Synonym
bone necroses
bone necrosis
bone necrosis (disorder)
bones--necrosis
necroses, bone
necrosis bone
necrosis of bone
necrosis, bone
osteochondronecrosis
osteonecroses
osteonecrosis [disease/finding]
Orphanet
DOID
UMLS
C0029445
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:44)
C0024141  |  systemic lupus erythematosus  |  9
C0029408  |  osteoarthritis  |  7
C0023448  |  lymphoblastic leukemia  |  6
C0023449  |  acute lymphoblastic leukemia  |  6
C0409974  |  lupus erythematosus  |  4
C0002895  |  sickle cell disease  |  4
C0023418  |  leukemia  |  4
C0006142  |  breast cancer  |  3
C0031099  |  periodontitis  |  3
C0019555  |  developmental dysplasia of the hip  |  2
C1332977  |  childhood leukemia  |  2
C0005940  |  bone disease  |  2
C0003864  |  arthritis  |  2
C0017205  |  gaucher disease  |  2
C0029443  |  osteomyelitis  |  2
C0026764  |  myeloma  |  2
C0029456  |  osteoporosis  |  2
C0026764  |  multiple myeloma  |  2
C0023234  |  perthes disease  |  2
C0031090  |  periodontal disease  |  2
C0042164  |  uveitis  |  2
C0398623  |  thrombophilia  |  2
C1253936  |  joint effusion  |  1
C0032461  |  polycythaemia  |  1
C0026769  |  multiple sclerosis  |  1
C0023470  |  myeloid leukemia  |  1
C0029434  |  osteogenesis imperfecta  |  1
C0023467  |  acute myeloid leukemia  |  1
C0032463  |  polycythaemia rubra vera  |  1
C0021053  |  immune disease  |  1
C0242666  |  protein s deficiency  |  1
C0020443  |  hypercholesterolemia  |  1
C0006444  |  bursitis  |  1
C0042769  |  virus infection  |  1
C0002895  |  sickle-cell disease  |  1
C0023452  |  childhood acute lymphoblastic leukemia  |  1
C0005940  |  bone diseases  |  1
C0162429  |  malnutrition  |  1
C0001261  |  actinomyces infection  |  1
C0376358  |  prostate cancer  |  1
C0003873  |  rheumatoid arthritis  |  1
C0022116  |  ischaemia  |  1
C0023418  |  leukaemia  |  1
C0007286  |  carpal tunnel syndrome  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:1)
MMP2  |  4313  |  CTD_human
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:14)
125  |  ADH1B  |  infer
217  |  ALDH2  |  infer
302  |  ANXA2  |  infer
335  |  APOA1  |  infer
338  |  APOB  |  infer
847  |  CAT  |  infer
1558  |  CYP2C8  |  infer
3091  |  HIF1A  |  infer
4524  |  MTHFR  |  infer
4846  |  NOS3  |  infer
5444  |  PON1  |  infer
5054  |  SERPINE1  |  infer
7298  |  TYMS  |  infer
7421  |  VDR  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:215)
6362  |  CCL18  |  DISEASES
64132  |  XYLT2  |  DISEASES
2273  |  FHL1  |  DISEASES
10857  |  PGRMC1  |  DISEASES
7076  |  TIMP1  |  DISEASES
54  |  ACP5  |  DISEASES
4313  |  MMP2  |  DISEASES
5327  |  PLAT  |  DISEASES
2091  |  FBL  |  DISEASES
7040  |  TGFB1  |  DISEASES
3036  |  HAS1  |  DISEASES
5444  |  PON1  |  DISEASES
1749  |  DLX5  |  DISEASES
5054  |  SERPINE1  |  DISEASES
6348  |  CCL3  |  DISEASES
1440  |  CSF3  |  DISEASES
30851  |  TAX1BP3  |  DISEASES
1655  |  DDX5  |  DISEASES
1277  |  COL1A1  |  DISEASES
2597  |  GAPDH  |  DISEASES
9896  |  FIG4  |  DISEASES
338  |  APOB  |  DISEASES
4317  |  MMP8  |  DISEASES
335  |  APOA1  |  DISEASES
4488  |  MSX2  |  DISEASES
5396  |  PRRX1  |  DISEASES
8600  |  TNFSF11  |  DISEASES
7291  |  TWIST1  |  DISEASES
652  |  BMP4  |  DISEASES
83596  |  BCL2L12  |  DISEASES
6495  |  SIX1  |  DISEASES
11135  |  CDC42EP1  |  DISEASES
968  |  CD68  |  DISEASES
5908  |  RAP1B  |  DISEASES
64428  |  NARFL  |  DISEASES
1401  |  CRP  |  DISEASES
325  |  APCS  |  DISEASES
1144  |  CHRND  |  DISEASES
1593  |  CYP27A1  |  DISEASES
3569  |  IL6  |  DISEASES
5004  |  ORM1  |  DISEASES
1588  |  CYP19A1  |  DISEASES
1134  |  CHRNA1  |  DISEASES
30061  |  SLC40A1  |  DISEASES
7450  |  VWF  |  DISEASES
4092  |  SMAD7  |  DISEASES
10156  |  RASA4  |  DISEASES
1  |  A1BG  |  DISEASES
23523  |  CABIN1  |  DISEASES
3553  |  IL1B  |  DISEASES
3791  |  KDR  |  DISEASES
2247  |  FGF2  |  DISEASES
950  |  SCARB2  |  DISEASES
1161  |  ERCC8  |  DISEASES
5243  |  ABCB1  |  DISEASES
347902  |  AMIGO2  |  DISEASES
121260  |  SLC15A4  |  DISEASES
150094  |  SIK1  |  DISEASES
1952  |  CELSR2  |  DISEASES
1513  |  CTSK  |  DISEASES
1807  |  DPYS  |  DISEASES
23196  |  FAM120A  |  DISEASES
90952  |  ESAM  |  DISEASES
128506  |  OCSTAMP  |  DISEASES
740  |  MRPL49  |  DISEASES
7424  |  VEGFC  |  DISEASES
2895  |  GRID2  |  DISEASES
5741  |  PTH  |  DISEASES
9453  |  GGPS1  |  DISEASES
654  |  BMP6  |  DISEASES
7070  |  THY1  |  DISEASES
89780  |  WNT3A  |  DISEASES
2849  |  GPR26  |  DISEASES
5468  |  PPARG  |  DISEASES
6352  |  CCL5  |  DISEASES
1145  |  CHRNE  |  DISEASES
4041  |  LRP5  |  DISEASES
4880  |  NPPC  |  DISEASES
308  |  ANXA5  |  DISEASES
26872  |  STEAP1  |  DISEASES
4982  |  TNFRSF11B  |  DISEASES
1672  |  DEFB1  |  DISEASES
4846  |  NOS3  |  DISEASES
116039  |  OSR2  |  DISEASES
81501  |  DCSTAMP  |  DISEASES
4783  |  NFIL3  |  DISEASES
9150  |  CTDP1  |  DISEASES
4314  |  MMP3  |  DISEASES
51129  |  ANGPTL4  |  DISEASES
50964  |  SOST  |  DISEASES
10921  |  RNPS1  |  DISEASES
51282  |  SCAND1  |  DISEASES
121340  |  SP7  |  DISEASES
1673  |  DEFB4A  |  DISEASES
2815  |  GP9  |  DISEASES
1140  |  CHRNB1  |  DISEASES
214  |  ALCAM  |  DISEASES
51162  |  EGFL7  |  DISEASES
9435  |  CHST2  |  DISEASES
2147  |  F2  |  DISEASES
5340  |  PLG  |  DISEASES
51316  |  PLAC8  |  DISEASES
26502  |  NARF  |  DISEASES
947  |  CD34  |  DISEASES
836  |  CASP3  |  DISEASES
5198  |  PFAS  |  DISEASES
8877  |  SPHK1  |  DISEASES
2629  |  GBA  |  DISEASES
7298  |  TYMS  |  DISEASES
284207  |  METRNL  |  DISEASES
1776  |  DNASE1L3  |  DISEASES
79649  |  MAP7D3  |  DISEASES
5345  |  SERPINF2  |  DISEASES
56975  |  FAM20C  |  DISEASES
23212  |  RRS1  |  DISEASES
3039  |  HBA1  |  DISEASES
4772  |  NFATC1  |  DISEASES
58491  |  ZNF71  |  DISEASES
3665  |  IRF7  |  DISEASES
5580  |  PRKCD  |  DISEASES
796  |  CALCA  |  DISEASES
2049  |  EPHB3  |  DISEASES
23762  |  OSBP2  |  DISEASES
2185  |  PTK2B  |  DISEASES
80864  |  EGFL8  |  DISEASES
3043  |  HBB  |  DISEASES
339761  |  CYP27C1  |  DISEASES
2152  |  F3  |  DISEASES
9138  |  ARHGEF1  |  DISEASES
1576  |  CYP3A4  |  DISEASES
3091  |  HIF1A  |  DISEASES
23583  |  SMUG1  |  DISEASES
26578  |  OSTF1  |  DISEASES
3605  |  IL17A  |  DISEASES
5170  |  PDPK1  |  DISEASES
1499  |  CTNNB1  |  DISEASES
302  |  ANXA2  |  DISEASES
8650  |  NUMB  |  DISEASES
1953  |  MEGF6  |  DISEASES
6651  |  SON  |  DISEASES
2224  |  FDPS  |  DISEASES
4745  |  NELL1  |  DISEASES
65989  |  DLK2  |  DISEASES
6714  |  SRC  |  DISEASES
1902  |  LPAR1  |  DISEASES
7456  |  WIPF1  |  DISEASES
9782  |  MATR3  |  DISEASES
6721  |  SREBF2  |  DISEASES
2475  |  MTOR  |  DISEASES
116443  |  GRIN3A  |  DISEASES
25896  |  INTS7  |  DISEASES
462  |  SERPINC1  |  DISEASES
2153  |  F5  |  DISEASES
4063  |  LY9  |  DISEASES
632  |  BGLAP  |  DISEASES
4803  |  NGF  |  DISEASES
9446  |  GSTO1  |  DISEASES
2258  |  FGF13  |  DISEASES
959  |  CD40LG  |  DISEASES
8790  |  FPGT  |  DISEASES
1791  |  DNTT  |  DISEASES
1558  |  CYP2C8  |  DISEASES
23648  |  SSBP3  |  DISEASES
860  |  RUNX2  |  DISEASES
6512  |  SLC1A7  |  DISEASES
7422  |  VEGFA  |  DISEASES
129685  |  TAF8  |  DISEASES
8879  |  SGPL1  |  DISEASES
2022  |  ENG  |  DISEASES
1955  |  MEGF9  |  DISEASES
22943  |  DKK1  |  DISEASES
7099  |  TLR4  |  DISEASES
57134  |  MAN1C1  |  DISEASES
7916  |  PRRC2A  |  DISEASES
4524  |  MTHFR  |  DISEASES
11074  |  TRIM31  |  DISEASES
646019  |  CBY3  |  DISEASES
7056  |  THBD  |  DISEASES
122183  |  PRR20A  |  DISEASES
127262  |  TPRG1L  |  DISEASES
650  |  BMP2  |  DISEASES
2683  |  B4GALT1  |  DISEASES
1280  |  COL2A1  |  DISEASES
25975  |  EGFL6  |  DISEASES
1645  |  AKR1C1  |  DISEASES
9189  |  ZBED1  |  DISEASES
90865  |  IL33  |  DISEASES
4487  |  MSX1  |  DISEASES
6736  |  SRY  |  DISEASES
27303  |  RBMS3  |  DISEASES
11173  |  ADAMTS7  |  DISEASES
6152  |  RPL24  |  DISEASES
6696  |  SPP1  |  DISEASES
9829  |  DNAJC6  |  DISEASES
79714  |  CCDC51  |  DISEASES
6387  |  CXCL12  |  DISEASES
655  |  BMP7  |  DISEASES
2047  |  EPHB1  |  DISEASES
319  |  APOF  |  DISEASES
89766  |  UMODL1  |  DISEASES
200424  |  TET3  |  DISEASES
176  |  ACAN  |  DISEASES
6916  |  TBXAS1  |  DISEASES
7576  |  ZNF28  |  DISEASES
7124  |  TNF  |  DISEASES
91833  |  WDR20  |  DISEASES
133396  |  IL31RA  |  DISEASES
8833  |  GMPS  |  DISEASES
10198  |  MPHOSPH9  |  DISEASES
2972  |  BRF1  |  DISEASES
124944  |  C17orf49  |  DISEASES
7732  |  RNF112  |  DISEASES
8792  |  TNFRSF11A  |  DISEASES
388815  |  MIR99AHG  |  DISEASES
100505832  |  PROX1-AS1  |  DISEASES
Locus(Waiting for update.)
Disease ID 541
Disease osteonecrosis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:36)
HP:0012531  |  Pain  |  11
HP:0002725  |  Systemic lupus erythematosus  |  9
HP:0002758  |  Osteoarthritis  |  7
HP:0006721  |  Acute lymphocytic leukemia  |  6
HP:0001909  |  Leukemia  |  4
HP:0002953  |  Vertebral compression fractures  |  4
HP:0000704  |  Pyorrhea  |  3
HP:0001928  |  Abnormal blood coagulation studies  |  3
HP:0003002  |  Breast carcinoma  |  3
HP:0001369  |  Arthritis  |  2
HP:0002653  |  Bone pain  |  2
HP:0100724  |  Hypercoagulability  |  2
HP:0006775  |  Multiple myeloma  |  2
HP:0030838  |  Hip pain  |  2
HP:0000939  |  Osteoporosis  |  2
HP:0000554  |  Uveitis  |  2
HP:0002754  |  Bone infection  |  2
HP:0002901  |  Hypocalcemia  |  2
HP:0003124  |  Elevated serum cholesterol  |  1
HP:0002829  |  Arthralgias  |  1
HP:0002721  |  Immunodeficiency  |  1
HP:0001370  |  Rheumatoid arthritis  |  1
HP:0004808  |  Acute myelogenous leukemia  |  1
HP:0001945  |  Fever  |  1
HP:0002960  |  Autoimmune condition  |  1
HP:0010885  |  Aseptic necrosis  |  1
HP:0012125  |  Prostate cancer  |  1
HP:0008807  |  Dysplastic acetabulae  |  1
HP:0003365  |  Coxalgia  |  1
HP:0012378  |  Fatigue  |  1
HP:0004395  |  Malnutrition  |  1
HP:0002756  |  Pathologic fracture  |  1
HP:0030041  |  Schmorl's node  |  1
HP:0003401  |  Paresthesia  |  1
HP:0012324  |  Myeloid leukemia  |  1
HP:0012532  |  Chronic pain  |  1
Disease ID 541
Disease osteonecrosis
Manually Symptom(Waiting for update.)
Text Mined Symptom(Waiting for update.)
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:2)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs10735810154592157421VDRumls:C0029445GAD[ Because folate-related and vitamin D-receptor genetic variants have been associated with bone and vasculature morbidity, these pharmacogenetic associations likely reflect the interaction of antileukemic medications with germline sensitivity to drug actio]0.0047340642004NANANANANA
rs1934951185940241558CYP2C8umls:C0029445GAD[Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.]0.0023670322008CYP2C81095038791CT
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:15)
CHR POS SNPID REF ALT ORI_SNPID PMID P_VALUE P_VALUE_TEXT OR/BETA CI95_TEXT GWAS_INITIAL_SAMPLE_SIZE SUB_POPULATION SUPER_POPULATION GWAS_TRAIT HPO_ID HPO_TERM DO_ID DO_TERM MESH_ID MESH_TERM EFO_ID EFO_TERM DOLITE_TERM RISK_ALLELE PUBLICATION_TYPE AA GENE_SYMBOL TYPE REFGENE
1196154898rs1886629CTrs1886629222678510.00000553NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralT
2166407511rs7588295AGrs7588295222678510.00000624NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralA
329954690rs17024608AGrs17024608222678517.47E-08NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralA
457941026rs11934877TCrs11934877222678510.00022NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralT
4165284574rs4431170AGrs4431170222678510.00000728NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralA
6120856203rs7740004TArs7740004222678510.00000787NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralT
858133986rs185048472GTrs185048472222678510.0000031NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralG
1096798548rs1934951CTrs1934951185940241.00E-06 12.75[3.70-43.50] 21 cases; 64 controlsNOPOP(85)ALL(85)NOPOP(85)ALL(85)Osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisD059266Bisphosphonate-Associated Osteonecrosis of the JawNANABone diseaseAseptic necrosis of boners1934951-TClinical TrialResearch Support, Non-U.S. Gov't
1099563198rs11189381TCrs11189381222678510.00000817NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralT
1123990404rs199876930TTACrs199876930222678510.00000994NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralNA
127074365rs11064477GArs11064477222678510.000000516NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralG
1395717906rs1678387TCrs1678387222678510.00002NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralC
1558306793rs12903202AGrs12903202222678510.00000915NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralA
1849201814rs17751934CTrs17751934222678510.00000916NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralC
2248598852rs5768434CTrs5768434222678510.000000117NANANA30 European cases; 1,743 European controlsEuropean(1773)ALL(1773)EUR(1773)ALL(1773)Bisphosphonate-induced osteonecrosis of the jawHPOID:0003368Abnormality of the femoral headDOID:10159osteonecrosisNANANANABone diseaseAseptic necrosis of boneNAResearch Support, N.I.H., ExtramuralC
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:1)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0029445zoledronic acidC088658-osteonecrosisMESH:D010020marker/mechanism17153267
FDA approved drug and dosage information(Total Drugs:2)
DiseaseID Drug_name active_ingredients strength Dosage Form/Route Marketing Status TE code RLD RS
MESH:D010020zometazoledronic acidEQ 4MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasonsINJECTABLE;IV (INFUSION)DiscontinuedNoneYesNo
MESH:D010020zometazoledronic acidEQ 4MG BASE/VIALINJECTABLE; IV (INFUSION)PrescriptionNoneNoNo
FDA labeling changes(Total Drugs:2)
DiseaseID Pediatric_Labeling_Date Trade_Name Generic_Name_or_Proper_Name Indications Studied Label Changes Summary Product Labeling BPCA(B) PREA(P) BPCA(B) and PREA(P) Pediatric Rule (R) Sponsor Pediatric Exclusivity Granted Date NNPS
MESH:D01002003/20/2008zometazoledronic acidSevere osteogenesis imperfectaZoledronic acid is not indicated for use in children Safety and effectiveness was studied in 152 pediatric patients with severe osteogenesis imperfecta aged 1 - 17 years. At one year, increases in BMD were observed in the zoledronic acid treatment group but the changes did not necessarily correlate with the risk for fracture or the incidence or severity of chronic bone pain Information on PK, clinical study, and AE profileLabelingB---Novartis12/21/2007FALSE'
MESH:D01002003/20/2008zometazoledronic acidSevere osteogenesis imperfectaZoledronic acid is not indicated for use in children Safety and effectiveness was studied in 152 pediatric patients with severe osteogenesis imperfecta aged 1 - 17 years. At one year, increases in BMD were observed in the zoledronic acid treatment group but the changes did not necessarily correlate with the risk for fracture or the incidence or severity of chronic bone pain Information on PK, clinical study, and AE profileLabelingB---Novartis12/21/2007FALSE'