PedAM

Pediatric Disease Annotations & Medicines


	osteoarthritis

Disease ID	283
Disease	osteoarthritis
Definition	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Synonym	[joint degeneration] or [osteoarthritis nos] [joint degeneration] or [osteoarthritis nos] (disorder) a o arthritides, degenerative arthritis degenerative arthritis osteoarthritis arthritis, degenerative arthritis, hypertrophic arthritis, senescent arthropathy, degenerative degenerative arthritides degenerative arthritis degenerative arthritis, nos degenerative arthropathy degenerative arthropathy (disorder) degenerative arthropathy, nos degenerative disease joint degenerative disease joints degenerative diseases joint degenerative joint disease degenerative joint disease (disorder) degenerative joint disease, nos degenerative osteoarthritis degenerative polyarthritis degenerative polyarthritis (disorder) degenerative polyarthritis, nos djd hypertrophic arthritis hypertrophic arthritis, nos hypertrophic polyarthritis hypertrophic polyarthritis, nos joint degeneration joint disease, degenerative o a oa oa - osteoarthritis oa - osteoarthrosis oa osteoarthritis oas osteoarthritides osteoarthritis (& [allied disorders]) osteoarthritis (disorder) osteoarthritis [disease/finding] osteoarthritis and allied disorders osteoarthritis arthritis osteoarthritis degenerative osteoarthritis nos osteoarthritis nos (disorder) osteoarthritis nos, of unspecified site osteoarthritis nos, of unspecified site (disorder) osteoarthritis, nos osteoarthroses osteoarthrosis osteoarthrosis (disorder) osteoarthrosis, nos osteoarthrosis, unspecified whether generalized or localized primary oa
OMIM	OMIM:165720 OMIM:206920
DOID	DOID:8398
UMLS	C0029408
MeSH	D010003
SNOMED-CT	SNOMEDCT_US_2016_09_01:225655006;SNOMEDCT_US_2016_09_01:396275006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:72) C0028754 \| obesity \| 20 C0011847 \| diabetes \| 9 C1956089 \| osteophytes \| 8 C0003864 \| arthritis \| 7 C0007222 \| cardiovascular disease \| 7 C0042373 \| vascular disease \| 7 C0039103 \| synovitis \| 6 C0003873 \| rheumatoid arthritis \| 6 C0948265 \| metabolic syndrome \| 6 C1253936 \| joint effusion \| 5 C0022408 \| arthropathy \| 5 C0011849 \| diabetes mellitus \| 5 C0020538 \| hypertension \| 5 C0011570 \| depression \| 5 C0002766 \| analgesia \| 4 C0016053 \| fibromyalgia \| 3 C0029456 \| osteoporosis \| 3 C0022408 \| joint disease \| 2 C0011860 \| type 2 diabetes \| 2 C0042870 \| vitamin d deficiency \| 2 C0019555 \| developmental dysplasia of the hip \| 2 C0006444 \| bursitis \| 2 C0030567 \| parkinson's disease \| 2 C0040053 \| thrombosis \| 2 C0037944 \| spinal stenosis \| 2 C0004153 \| atherosclerosis \| 2 C0042870 \| vitamin d defic \| 2 C0007222 \| cardiovascular diseases \| 2 C0011860 \| type 2 diabetes mellitus \| 2 C1956089 \| osteophyte \| 2 C0020676 \| hypothyroidism \| 2 C0023798 \| lipoma \| 2 C0042373 \| vascular diseases \| 2 C0005940 \| bone disease \| 1 C0024115 \| pulmonary disease \| 1 C0700594 \| radiculopathy \| 1 C2697932 \| loeys-dietz syndrome \| 1 C1956089 \| osteophytosis \| 1 C0036440 \| idiopathic scoliosis \| 1 C0029454 \| osteopetrosis \| 1 C0042974 \| von willebrand disease \| 1 C0038012 \| spondylitis \| 1 C0036439 \| scoliosis \| 1 C0035435 \| rheumatism \| 1 C0151744 \| ischaemic heart disease \| 1 C0024796 \| marfan syndrome \| 1 C0037317 \| sleep disturbances \| 1 C0038018 \| spondylolysis \| 1 C0553730 \| chondrocalcinosis \| 1 C0002871 \| anemia \| 1 C0016977 \| gallbladder disease \| 1 C0003864 \| inflammatory arthritis \| 1 C0029434 \| osteogenesis imperfecta \| 1 C0013720 \| ehlers-danlos syndrome \| 1 C0018099 \| gout \| 1 C0015645 \| fasciitis \| 1 C0001206 \| acromegaly \| 1 C0040188 \| tic disorders \| 1 C0037317 \| sleep disturbance \| 1 C0038015 \| spondyloepiphyseal dysplasia congenita \| 1 C0018799 \| heart disease \| 1 C0029408 \| degenerative joint disease \| 1 C0158266 \| degenerative disc disease \| 1 C0238124 \| necrotizing fasciitis \| 1 C0019618 \| histiocytosis \| 1 C0002395 \| alzheimer's disease \| 1 C0003864 \| joint inflammation \| 1 C0007789 \| cerebral palsy \| 1 C0038015 \| spondyloepiphyseal dysplasia \| 1 C0023890 \| cirrhosis \| 1 C0877149 \| patellofemoral pain syndrome \| 1 C0085681 \| hyperphosphatemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:94) CHI3L1 \| 1116 \| CTD_human SLC2A1 \| 6513 \| CTD_human EEF2 \| 1938 \| CTD_human COL6A2 \| 1292 \| CTD_human SOD2 \| 6648 \| CTD_human SDHA \| 6389 \| CTD_human ENO1 \| 2023 \| CTD_human ACTB \| 60 \| CTD_human ATP1A3 \| 478 \| CTD_human SMAD3 \| 4088 \| CTD_human CTSD \| 1509 \| CTD_human PDCD6IP \| 10015 \| CTD_human COL1A2 \| 1278 \| CTD_human CXCL2 \| 2920 \| CTD_human IDH2 \| 3418 \| CTD_human BMP6 \| 654 \| CTD_human BMP4 \| 652 \| CTD_human RUNX2 \| 860 \| CTD_human TRPV4 \| 59341 \| CTD_human IL1B \| 3553 \| CTD_human LTBP3 \| 4054 \| CTD_human DDX3X \| 1654 \| CTD_human ASPN \| 54829 \| CTD_human MSN \| 4478 \| CTD_human PBRM1 \| 55193 \| GWASCAT FTL \| 2512 \| CTD_human OPA1 \| 4976 \| CTD_human EZR \| 7430 \| CTD_human CAMK2B \| 816 \| GWASCAT NDUFV1 \| 4723 \| CTD_human COL2A1 \| 1280 \| CTD_human AKR1C1 \| 1645 \| CTD_human FRZB \| 2487 \| CLINVAR;CTD_human MATN3 \| 4148 \| CTD_human TRIM2 \| 23321 \| CTD_human NDUFS8 \| 4728 \| CTD_human COG5 \| 10466 \| GWASCAT EDIL3 \| 10085 \| CTD_human VIM \| 7431 \| CTD_human TGM2 \| 7052 \| CTD_human COMP \| 1311 \| CTD_human PPARG \| 5468 \| CTD_human PLOD2 \| 5352 \| CTD_human PPP2R1A \| 5518 \| CTD_human CLU \| 1191 \| CTD_human MYH13 \| 8735 \| CTD_human CALCA \| 796 \| CTD_human ETFA \| 2108 \| CTD_human DOT1L \| 84444 \| GWASCAT GDF5 \| 8200 \| CTD_human VDAC2 \| 7417 \| CTD_human AKR1C2 \| 1646 \| CTD_human GAPDH \| 2597 \| CTD_human ATP6V1B2 \| 526 \| CTD_human PDHA1 \| 5160 \| CTD_human DUS4L \| 11062 \| GWASCAT IDH3A \| 3419 \| CTD_human SEC23A \| 10484 \| CTD_human SCRN1 \| 9805 \| CTD_human DAPP1 \| 27071 \| CTD_human ALDH1A2 \| 8854 \| CTD_human;GWASCAT ESD \| 2098 \| CTD_human NME2 \| 4831 \| CTD_human RAN \| 5901 \| CTD_human GLS \| 2744 \| CTD_human DPYSL2 \| 1808 \| CTD_human TXNRD1 \| 7296 \| CTD_human CLIC1 \| 1192 \| CTD_human ACAA2 \| 10449 \| CTD_human SUPT3H \| 8464 \| GWASCAT POU3F3 \| 5455 \| CTD_human PLS3 \| 5358 \| CTD_human SGCG \| 6445 \| CTD_human GSTK1 \| 373156 \| CTD_human HADHA \| 3030 \| CTD_human YWHAQ \| 10971 \| CTD_human SNORD19 \| 692089 \| GWASCAT AK4 \| 205 \| CTD_human ACO1 \| 48 \| CTD_human P3H3 \| 10536 \| CTD_human HIBCH \| 26275 \| CTD_human TFPI2 \| 7980 \| CTD_human MVP \| 9961 \| CTD_human CXCL6 \| 6372 \| CTD_human ISOC2 \| 79763 \| CTD_human PSMB1 \| 5689 \| CTD_human PLCD1 \| 5333 \| CTD_human SDCBP \| 6386 \| CTD_human IMMT \| 10989 \| CTD_human MCF2L \| 23263 \| GWASCAT RCN3 \| 57333 \| CTD_human CLIC4 \| 25932 \| CTD_human GNL3 \| 26354 \| GWASCAT TRAP1 \| 10131 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:63) 8038 \| ADAM12 \| infer 9508 \| ADAMTS3 \| infer 11096 \| ADAMTS5 \| infer 367 \| AR \| infer 54829 \| ASPN \| infer 650 \| BMP2 \| infer 653 \| BMP5 \| infer 796 \| CALCA \| infer 801 \| CALM1 \| infer 948 \| CD36 \| infer 8483 \| CILP \| infer 7123 \| CLEC3B \| infer 10466 \| COG5 \| infer 1301 \| COL11A1 \| infer 1302 \| COL11A2 \| infer 1277 \| COL1A1 \| infer 1280 \| COL2A1 \| infer 1297 \| COL9A1 \| infer 1298 \| COL9A2 \| infer 1299 \| COL9A3 \| infer 1311 \| COMP \| infer 1401 \| CRP \| infer 1734 \| DIO2 \| infer 5167 \| ENPP1 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 2487 \| FRZB \| infer 8200 \| GDF5 \| infer 3077 \| HFE \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3479 \| IGF1 \| infer 3490 \| IGFBP7 \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3554 \| IL1R1 \| infer 3557 \| IL1RN \| infer 3566 \| IL4R \| infer 3569 \| IL6 \| infer 9365 \| KL \| infer 11278 \| KLF12 \| infer 23143 \| LRCH1 \| infer 4041 \| LRP5 \| infer 4040 \| LRP6 \| infer 4146 \| MATN1 \| infer 4148 \| MATN3 \| infer 23263 \| MCF2L \| infer 4313 \| MMP2 \| infer 9612 \| NCOR2 \| infer 9060 \| PAPSS2 \| infer 5743 \| PTGS2 \| infer 388 \| RHOB \| infer 12 \| SERPINA3 \| infer 1836 \| SLC26A2 \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer 7130 \| TNFAIP6 \| infer 4982 \| TNFRSF11B \| infer 7132 \| TNFRSF1A \| infer 7133 \| TNFRSF1B \| infer 7421 \| VDR \| infer 8840 \| WISP1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:837) 6362 \| CCL18 \| DISEASES 1856 \| DVL2 \| DISEASES 6376 \| CX3CL1 \| DISEASES 928 \| CD9 \| DISEASES 10867 \| TSPAN9 \| DISEASES 64132 \| XYLT2 \| DISEASES 84245 \| MRI1 \| DISEASES 1634 \| DCN \| DISEASES 2896 \| GRN \| DISEASES 79931 \| TNIP3 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 6694 \| SPP2 \| DISEASES 4804 \| NGFR \| DISEASES 8839 \| WISP2 \| DISEASES 51314 \| NME8 \| DISEASES 8646 \| CHRD \| DISEASES 2099 \| ESR1 \| DISEASES 23411 \| SIRT1 \| DISEASES 4616 \| GADD45B \| DISEASES 4282 \| MIF \| DISEASES 5008 \| OSM \| DISEASES 5594 \| MAPK1 \| DISEASES 7494 \| XBP1 \| DISEASES 3162 \| HMOX1 \| DISEASES 150356 \| CHADL \| DISEASES 22795 \| NID2 \| DISEASES 1511 \| CTSG \| DISEASES 2999 \| GZMH \| DISEASES 328 \| APEX1 \| DISEASES 4792 \| NFKBIA \| DISEASES 5173 \| PDYN \| DISEASES 10005 \| ACOT8 \| DISEASES 10857 \| PGRMC1 \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 54 \| ACP5 \| DISEASES 4313 \| MMP2 \| DISEASES 6367 \| CCL22 \| DISEASES 4150 \| MAZ \| DISEASES 6422 \| SFRP1 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 3972 \| LHB \| DISEASES 56729 \| RETN \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 6822 \| SULT2A1 \| DISEASES 3036 \| HAS1 \| DISEASES 1311 \| COMP \| DISEASES 3082 \| HGF \| DISEASES 51384 \| WNT16 \| DISEASES 10135 \| NAMPT \| DISEASES 26959 \| HBP1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 5919 \| RARRES2 \| DISEASES 2662 \| GDF10 \| DISEASES 657 \| BMPR1A \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 6198 \| RPS6KB1 \| DISEASES 6347 \| CCL2 \| DISEASES 1277 \| COL1A1 \| DISEASES 7448 \| VTN \| DISEASES 952 \| CD38 \| DISEASES 3381 \| IBSP \| DISEASES 6372 \| CXCL6 \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 595 \| CCND1 \| DISEASES 4254 \| KITLG \| DISEASES 51561 \| IL23A \| DISEASES 2735 \| GLI1 \| DISEASES 11272 \| PRR4 \| DISEASES 4256 \| MGP \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 1432 \| MAPK14 \| DISEASES 54346 \| UNC93A \| DISEASES 9450 \| LY86 \| DISEASES 4015 \| LOX \| DISEASES 6678 \| SPARC \| DISEASES 3565 \| IL4 \| DISEASES 56920 \| SEMA3G \| DISEASES 51185 \| CRBN \| DISEASES 28972 \| SPCS1 \| DISEASES 374291 \| NDUFS7 \| DISEASES 3485 \| IGFBP2 \| DISEASES 3488 \| IGFBP5 \| DISEASES 2677 \| GGCX \| DISEASES 3554 \| IL1R1 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 388714 \| FMO6P \| DISEASES 1509 \| CTSD \| DISEASES 4317 \| MMP8 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 27145 \| FILIP1 \| DISEASES 7128 \| TNFAIP3 \| DISEASES 83449 \| PMFBP1 \| DISEASES 11064 \| CNTRL \| DISEASES 7043 \| TGFB3 \| DISEASES 1843 \| DUSP1 \| DISEASES 4360 \| MRC1 \| DISEASES 8600 \| TNFSF11 \| DISEASES 1958 \| EGR1 \| DISEASES 847 \| CAT \| DISEASES 4852 \| NPY \| DISEASES 3624 \| INHBA \| DISEASES 7291 \| TWIST1 \| DISEASES 5552 \| SRGN \| DISEASES 4035 \| LRP1 \| DISEASES 2166 \| FAAH \| DISEASES 1300 \| COL10A1 \| DISEASES 7130 \| TNFAIP6 \| DISEASES 79586 \| CHPF \| DISEASES 4159 \| MC3R \| DISEASES 5184 \| PEPD \| DISEASES 1948 \| EFNB2 \| DISEASES 3659 \| IRF1 \| DISEASES 652 \| BMP4 \| DISEASES 6662 \| SOX9 \| DISEASES 4620 \| MYH2 \| DISEASES 30833 \| NT5C \| DISEASES 718 \| C3 \| DISEASES 7408 \| VASP \| DISEASES 8189 \| SYMPK \| DISEASES 9572 \| NR1D1 \| DISEASES 5199 \| CFP \| DISEASES 23780 \| APOL2 \| DISEASES 3976 \| LIF \| DISEASES 3235 \| HOXD9 \| DISEASES 8854 \| ALDH1A2 \| DISEASES 968 \| CD68 \| DISEASES 79148 \| MMP28 \| DISEASES 6351 \| CCL4 \| DISEASES 8840 \| WISP1 \| DISEASES 3630 \| INS \| DISEASES 11024 \| LILRA1 \| DISEASES 26025 \| PCDHGA12 \| DISEASES 9026 \| HIP1R \| DISEASES 55902 \| ACSS2 \| DISEASES 10266 \| RAMP2 \| DISEASES 22856 \| CHSY1 \| DISEASES 3958 \| LGALS3 \| DISEASES 6382 \| SDC1 \| DISEASES 8864 \| PER2 \| DISEASES 91107 \| TRIM47 \| DISEASES 182 \| JAG1 \| DISEASES 1401 \| CRP \| DISEASES 84327 \| ZBED3 \| DISEASES 1116 \| CHI3L1 \| DISEASES 27299 \| ADAMDEC1 \| DISEASES 10906 \| TRAFD1 \| DISEASES 4907 \| NT5E \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 1101 \| CHAD \| DISEASES 3557 \| IL1RN \| DISEASES 2995 \| GYPC \| DISEASES 5168 \| ENPP2 \| DISEASES 6366 \| CCL21 \| DISEASES 29113 \| C6orf15 \| DISEASES 7097 \| TLR2 \| DISEASES 23213 \| SULF1 \| DISEASES 4316 \| MMP7 \| DISEASES 4322 \| MMP13 \| DISEASES 7057 \| THBS1 \| DISEASES 1588 \| CYP19A1 \| DISEASES 1559 \| CYP2C9 \| DISEASES 3685 \| ITGAV \| DISEASES 1833 \| EPYC \| DISEASES 11213 \| IRAK3 \| DISEASES 5858 \| PZP \| DISEASES 64131 \| XYLT1 \| DISEASES 7450 \| VWF \| DISEASES 10162 \| LPCAT3 \| DISEASES 59341 \| TRPV4 \| DISEASES 8483 \| CILP \| DISEASES 51201 \| ZDHHC2 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 83690 \| CRISPLD1 \| DISEASES 8989 \| TRPA1 \| DISEASES 64750 \| SMURF2 \| DISEASES 4969 \| OGN \| DISEASES 9368 \| SLC9A3R1 \| DISEASES 495 \| ATP4A \| DISEASES 7077 \| TIMP2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 5595 \| MAPK3 \| DISEASES 1 \| A1BG \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 8190 \| MIA \| DISEASES 23476 \| BRD4 \| DISEASES 1991 \| ELANE \| DISEASES 2034 \| EPAS1 \| DISEASES 3574 \| IL7 \| DISEASES 3791 \| KDR \| DISEASES 4162 \| MCAM \| DISEASES 1386 \| ATF2 \| DISEASES 79594 \| MUL1 \| DISEASES 8808 \| IL1RL2 \| DISEASES 8807 \| IL18RAP \| DISEASES 2247 \| FGF2 \| DISEASES 3589 \| IL11 \| DISEASES 9759 \| HDAC4 \| DISEASES 1356 \| CP \| DISEASES 7474 \| WNT5A \| DISEASES 6774 \| STAT3 \| DISEASES 80725 \| SRCIN1 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 26998 \| FETUB \| DISEASES 1462 \| VCAN \| DISEASES 6897 \| TARS \| DISEASES 51176 \| LEF1 \| DISEASES 1950 \| EGF \| DISEASES 5307 \| PITX1 \| DISEASES 10512 \| SEMA3C \| DISEASES 10371 \| SEMA3A \| DISEASES 1390 \| CREM \| DISEASES 25824 \| PRDX5 \| DISEASES 26229 \| B3GAT3 \| DISEASES 27074 \| LAMP3 \| DISEASES 11062 \| DUS4L \| DISEASES 1021 \| CDK6 \| DISEASES 3263 \| HPX \| DISEASES 55830 \| GLT8D1 \| DISEASES 3373 \| HYAL1 \| DISEASES 7078 \| TIMP3 \| DISEASES 283358 \| B4GALNT3 \| DISEASES 4060 \| LUM \| DISEASES 2252 \| FGF7 \| DISEASES 3480 \| IGF1R \| DISEASES 1009 \| CDH11 \| DISEASES 7157 \| TP53 \| DISEASES 396 \| ARHGDIA \| DISEASES 3487 \| IGFBP4 \| DISEASES 593 \| BCKDHA \| DISEASES 7711 \| ZNF155 \| DISEASES 150094 \| SIK1 \| DISEASES 207 \| AKT1 \| DISEASES 81794 \| ADAMTS10 \| DISEASES 963 \| CD53 \| DISEASES 6282 \| S100A11 \| DISEASES 1513 \| CTSK \| DISEASES 7483 \| WNT9A \| DISEASES 388 \| RHOB \| DISEASES 805 \| CALM2 \| DISEASES 5746 \| PTH2R \| DISEASES 170690 \| ADAMTS16 \| DISEASES 3001 \| GZMA \| DISEASES 5295 \| PIK3R1 \| DISEASES 1404 \| HAPLN1 \| DISEASES 8817 \| FGF18 \| DISEASES 4851 \| NOTCH1 \| DISEASES 3026 \| HABP2 \| DISEASES 740 \| MRPL49 \| DISEASES 4319 \| MMP10 \| DISEASES 3606 \| IL18 \| DISEASES 5741 \| PTH \| DISEASES 83439 \| TCF7L1 \| DISEASES 2321 \| FLT1 \| DISEASES 23171 \| GPD1L \| DISEASES 2697 \| GJA1 \| DISEASES 3672 \| ITGA1 \| DISEASES 5352 \| PLOD2 \| DISEASES 654 \| BMP6 \| DISEASES 3081 \| HGD \| DISEASES 223117 \| SEMA3D \| DISEASES 7070 \| THY1 \| DISEASES 56172 \| ANKH \| DISEASES 116337 \| PANX3 \| DISEASES 7345 \| UCHL1 \| DISEASES 89780 \| WNT3A \| DISEASES 23643 \| LY96 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 11096 \| ADAMTS5 \| DISEASES 1836 \| SLC26A2 \| DISEASES 1436 \| CSF1R \| DISEASES 4325 \| MMP16 \| DISEASES 9508 \| ADAMTS3 \| DISEASES 392255 \| GDF6 \| DISEASES 7079 \| TIMP4 \| DISEASES 5468 \| PPARG \| DISEASES 146433 \| IL34 \| DISEASES 4091 \| SMAD6 \| DISEASES 909 \| CD1A \| DISEASES 715 \| C1R \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 404037 \| HAPLN4 \| DISEASES 148113 \| CILP2 \| DISEASES 23387 \| SIK3 \| DISEASES 51043 \| ZBTB7B \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 221914 \| GPC2 \| DISEASES 6352 \| CCL5 \| DISEASES 126123 \| IZUMO2 \| DISEASES 7471 \| WNT1 \| DISEASES 401827 \| MSLNL \| DISEASES 4041 \| LRP5 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 2487 \| FRZB \| DISEASES 7039 \| TGFA \| DISEASES 11167 \| FSTL1 \| DISEASES 3577 \| CXCR1 \| DISEASES 3549 \| IHH \| DISEASES 152185 \| SPICE1 \| DISEASES 213 \| ALB \| DISEASES 84818 \| IL17RC \| DISEASES 2921 \| CXCL3 \| DISEASES 6374 \| CXCL5 \| DISEASES 7349 \| UCN \| DISEASES 7123 \| CLEC3B \| DISEASES 1230 \| CCR1 \| DISEASES 308 \| ANXA5 \| DISEASES 3248 \| HPGD \| DISEASES 3600 \| IL15 \| DISEASES 2150 \| F2RL1 \| DISEASES 4724 \| NDUFS4 \| DISEASES 81789 \| TIGD6 \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 10466 \| COG5 \| DISEASES 25862 \| USP49 \| DISEASES 1278 \| COL1A2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 9311 \| ASIC3 \| DISEASES 81034 \| SLC25A32 \| DISEASES 81501 \| DCSTAMP \| DISEASES 2350 \| FOLR2 \| DISEASES 23588 \| KLHDC2 \| DISEASES 84659 \| RNASE7 \| DISEASES 79841 \| AGBL2 \| DISEASES 4714 \| NDUFB8 \| DISEASES 4314 \| MMP3 \| DISEASES 290 \| ANPEP \| DISEASES 26585 \| GREM1 \| DISEASES 6632 \| SNRPD1 \| DISEASES 51129 \| ANGPTL4 \| DISEASES 50964 \| SOST \| DISEASES 79058 \| ASPSCR1 \| DISEASES 6356 \| CCL11 \| DISEASES 5604 \| MAP2K1 \| DISEASES 79663 \| HSPBAP1 \| DISEASES 8313 \| AXIN2 \| DISEASES 3479 \| IGF1 \| DISEASES 2845 \| GPR22 \| DISEASES 121340 \| SP7 \| DISEASES 5734 \| PTGER4 \| DISEASES 3603 \| IL16 \| DISEASES 3308 \| HSPA4 \| DISEASES 140738 \| TMEM37 \| DISEASES 3688 \| ITGB1 \| DISEASES 6869 \| TACR1 \| DISEASES 54360 \| CYTL1 \| DISEASES 1281 \| COL3A1 \| DISEASES 5028 \| P2RY1 \| DISEASES 3596 \| IL13 \| DISEASES 5046 \| PCSK6 \| DISEASES 1051 \| CEBPB \| DISEASES 3627 \| CXCL10 \| DISEASES 50515 \| CHST11 \| DISEASES 23450 \| SF3B3 \| DISEASES 81851 \| KRTAP1-1 \| DISEASES 214 \| ALCAM \| DISEASES 3575 \| IL7R \| DISEASES 2353 \| FOS \| DISEASES 84309 \| NUDT16L1 \| DISEASES 56246 \| MRAP \| DISEASES 3037 \| HAS2 \| DISEASES 6383 \| SDC2 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 9902 \| MRC2 \| DISEASES 54205 \| CYCS \| DISEASES 4323 \| MMP14 \| DISEASES 27289 \| RND1 \| DISEASES 2147 \| F2 \| DISEASES 6363 \| CCL19 \| DISEASES 81029 \| WNT5B \| DISEASES 5340 \| PLG \| DISEASES 54715 \| RBFOX1 \| DISEASES 4973 \| OLR1 \| DISEASES 23529 \| CLCF1 \| DISEASES 1072 \| CFL1 \| DISEASES 6868 \| ADAM17 \| DISEASES 169270 \| ZNF596 \| DISEASES 947 \| CD34 \| DISEASES 8061 \| FOSL1 \| DISEASES 55790 \| CSGALNACT1 \| DISEASES 836 \| CASP3 \| DISEASES 358 \| AQP1 \| DISEASES 1240 \| CMKLR1 \| DISEASES 5319 \| PLA2G1B \| DISEASES 8837 \| CFLAR \| DISEASES 3952 \| LEP \| DISEASES 5198 \| PFAS \| DISEASES 998 \| CDC42 \| DISEASES 1191 \| CLU \| DISEASES 1604 \| CD55 \| DISEASES 8560 \| DEGS1 \| DISEASES 5551 \| PRF1 \| DISEASES 2744 \| GLS \| DISEASES 166012 \| CHST13 \| DISEASES 64388 \| GREM2 \| DISEASES 27319 \| BHLHE22 \| DISEASES 7358 \| UGDH \| DISEASES 3579 \| CXCR2 \| DISEASES 9370 \| ADIPOQ \| DISEASES 220032 \| GDPD4 \| DISEASES 23765 \| IL17RA \| DISEASES 6863 \| TAC1 \| DISEASES 5745 \| PTH1R \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 8100 \| IFT88 \| DISEASES 55600 \| ITLN1 \| DISEASES 2535 \| FZD2 \| DISEASES 2 \| A2M \| DISEASES 3309 \| HSPA5 \| DISEASES 8408 \| ULK1 \| DISEASES 10586 \| MAB21L2 \| DISEASES 9235 \| IL32 \| DISEASES 55553 \| SOX6 \| DISEASES 9622 \| KLK4 \| DISEASES 3052 \| HCCS \| DISEASES 4094 \| MAF \| DISEASES 7433 \| VIPR1 \| DISEASES 4843 \| NOS2 \| DISEASES 633 \| BGN \| DISEASES 1435 \| CSF1 \| DISEASES 4772 \| NFATC1 \| DISEASES 716 \| C1S \| DISEASES 9241 \| NOG \| DISEASES 11016 \| ATF7 \| DISEASES 50616 \| IL22 \| DISEASES 8651 \| SOCS1 \| DISEASES 842 \| CASP9 \| DISEASES 9021 \| SOCS3 \| DISEASES 5155 \| PDGFB \| DISEASES 3953 \| LEPR \| DISEASES 80213 \| TM2D3 \| DISEASES 6401 \| SELE \| DISEASES 796 \| CALCA \| DISEASES 942 \| CD86 \| DISEASES 1675 \| CFD \| DISEASES 29940 \| DSE \| DISEASES 1233 \| CCR4 \| DISEASES 4088 \| SMAD3 \| DISEASES 388566 \| ZNF470 \| DISEASES 80864 \| EGFL8 \| DISEASES 5600 \| MAPK11 \| DISEASES 682 \| BSG \| DISEASES 2152 \| F3 \| DISEASES 5025 \| P2RX4 \| DISEASES 51548 \| SIRT6 \| DISEASES 114548 \| NLRP3 \| DISEASES 112744 \| IL17F \| DISEASES 7189 \| TRAF6 \| DISEASES 284004 \| HEXDC \| DISEASES 3091 \| HIF1A \| DISEASES 4862 \| NPAS2 \| DISEASES 2246 \| FGF1 \| DISEASES 66005 \| CHID1 \| DISEASES 857 \| CAV1 \| DISEASES 5329 \| PLAUR \| DISEASES 2309 \| FOXO3 \| DISEASES 2261 \| FGFR3 \| DISEASES 2358 \| FPR2 \| DISEASES 4137 \| MAPT \| DISEASES 7477 \| WNT7B \| DISEASES 5764 \| PTN \| DISEASES 1299 \| COL9A3 \| DISEASES 51094 \| ADIPOR1 \| DISEASES 2804 \| GOLGB1 \| DISEASES 1508 \| CTSB \| DISEASES 9536 \| PTGES \| DISEASES 3146 \| HMGB1 \| DISEASES 8785 \| MATN4 \| DISEASES 9474 \| ATG5 \| DISEASES 197021 \| LCTL \| DISEASES 7464 \| CORO2A \| DISEASES 5549 \| PRELP \| DISEASES 2100 \| ESR2 \| DISEASES 3605 \| IL17A \| DISEASES 467 \| ATF3 \| DISEASES 1499 \| CTNNB1 \| DISEASES 9672 \| SDC3 \| DISEASES 80833 \| APOL3 \| DISEASES 8073 \| PTP4A2 \| DISEASES 5606 \| MAP2K3 \| DISEASES 80142 \| PTGES2 \| DISEASES 538 \| ATP7A \| DISEASES 6677 \| SPAM1 \| DISEASES 2879 \| GPX4 \| DISEASES 142679 \| DUSP19 \| DISEASES 6275 \| S100A4 \| DISEASES 9719 \| ADAMTSL2 \| DISEASES 2335 \| FN1 \| DISEASES 2331 \| FMOD \| DISEASES 728 \| C5AR1 \| DISEASES 2202 \| EFEMP1 \| DISEASES 8764 \| TNFRSF14 \| DISEASES 26503 \| SLC17A5 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 11060 \| WWP2 \| DISEASES 219844 \| HYLS1 \| DISEASES 6288 \| SAA1 \| DISEASES 1953 \| MEGF6 \| DISEASES 5733 \| PTGER3 \| DISEASES 64116 \| SLC39A8 \| DISEASES 3683 \| ITGAL \| DISEASES 8794 \| TNFRSF10C \| DISEASES 8751 \| ADAM15 \| DISEASES 801 \| CALM1 \| DISEASES 79602 \| ADIPOR2 \| DISEASES 1297 \| COL9A1 \| DISEASES 65989 \| DLK2 \| DISEASES 60 \| ACTB \| DISEASES 23032 \| USP33 \| DISEASES 8692 \| HYAL2 \| DISEASES 2050 \| EPHB4 \| DISEASES 6714 \| SRC \| DISEASES 1524 \| CX3CR1 \| DISEASES 841 \| CASP8 \| DISEASES 131873 \| COL6A6 \| DISEASES 2526 \| FUT4 \| DISEASES 117583 \| PARD3B \| DISEASES 6364 \| CCL20 \| DISEASES 1902 \| LPAR1 \| DISEASES 23644 \| EDC4 \| DISEASES 7048 \| TGFBR2 \| DISEASES 4217 \| MAP3K5 \| DISEASES 9332 \| CD163 \| DISEASES 1735 \| DIO3 \| DISEASES 799 \| CALCR \| DISEASES 1454 \| CSNK1E \| DISEASES 55959 \| SULF2 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 3164 \| NR4A1 \| DISEASES 5599 \| MAPK8 \| DISEASES 4326 \| MMP17 \| DISEASES 54106 \| TLR9 \| DISEASES 5167 \| ENPP1 \| DISEASES 6772 \| STAT1 \| DISEASES 23245 \| ASTN2 \| DISEASES 2475 \| MTOR \| DISEASES 7855 \| FZD5 \| DISEASES 5742 \| PTGS1 \| DISEASES 8838 \| WISP3 \| DISEASES 4513 \| MT-CO2 \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 9444 \| QKI \| DISEASES 8678 \| BECN1 \| DISEASES 7052 \| TGM2 \| DISEASES 961 \| CD47 \| DISEASES 142 \| PARP1 \| DISEASES 7042 \| TGFB2 \| DISEASES 39 \| ACAT2 \| DISEASES 22828 \| SCAF8 \| DISEASES 26254 \| OPTC \| DISEASES 7432 \| VIP \| DISEASES 5788 \| PTPRC \| DISEASES 5321 \| PLA2G4A \| DISEASES 5743 \| PTGS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 167826 \| OLIG3 \| DISEASES 4921 \| DDR2 \| DISEASES 1490 \| CTGF \| DISEASES 9507 \| ADAMTS4 \| DISEASES 2117 \| ETV3 \| DISEASES 632 \| BGLAP \| DISEASES 7059 \| THBS3 \| DISEASES 8038 \| ADAM12 \| DISEASES 6283 \| S100A12 \| DISEASES 6281 \| S100A10 \| DISEASES 5654 \| HTRA1 \| DISEASES 1520 \| CTSS \| DISEASES 6001 \| RGS10 \| DISEASES 5550 \| PREP \| DISEASES 2209 \| FCGR1A \| DISEASES 1268 \| CNR1 \| DISEASES 4803 \| NGF \| DISEASES 9446 \| GSTO1 \| DISEASES 119392 \| SFR1 \| DISEASES 1117 \| CHI3L2 \| DISEASES 8277 \| TKTL1 \| DISEASES 3654 \| IRAK1 \| DISEASES 8771 \| TNFRSF6B \| DISEASES 1301 \| COL11A1 \| DISEASES 55118 \| CRTAC1 \| DISEASES 2258 \| FGF13 \| DISEASES 959 \| CD40LG \| DISEASES 2239 \| GPC4 \| DISEASES 653 \| BMP5 \| DISEASES 2941 \| GSTA4 \| DISEASES 163782 \| KANK4 \| DISEASES 1791 \| DNTT \| DISEASES 6005 \| RHAG \| DISEASES 3725 \| JUN \| DISEASES 860 \| RUNX2 \| DISEASES 8464 \| SUPT3H \| DISEASES 5730 \| PTGDS \| DISEASES 1289 \| COL5A1 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 8202 \| NCOA3 \| DISEASES 91851 \| CHRDL1 \| DISEASES 5900 \| RALGDS \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 6385 \| SDC4 \| DISEASES 1298 \| COL9A2 \| DISEASES 5328 \| PLAU \| DISEASES 100 \| ADA \| DISEASES 80149 \| ZC3H12A \| DISEASES 2022 \| ENG \| DISEASES 140766 \| ADAMTS14 \| DISEASES 339488 \| TFAP2E \| DISEASES 1025 \| CDK9 \| DISEASES 5230 \| PGK1 \| DISEASES 2833 \| CXCR3 \| DISEASES 4146 \| MATN1 \| DISEASES 7185 \| TRAF1 \| DISEASES 7321 \| UBE2D1 \| DISEASES 1955 \| MEGF9 \| DISEASES 22943 \| DKK1 \| DISEASES 7099 \| TLR4 \| DISEASES 9968 \| MED12 \| DISEASES 113220 \| KIF12 \| DISEASES 57134 \| MAN1C1 \| DISEASES 8200 \| GDF5 \| DISEASES 240 \| ALOX5 \| DISEASES 7295 \| TXN \| DISEASES 1896 \| EDA \| DISEASES 3339 \| HSPG2 \| DISEASES 1302 \| COL11A2 \| DISEASES 11326 \| VSIG4 \| DISEASES 5535 \| PPP3R2 \| DISEASES 249 \| ALPL \| DISEASES 7046 \| TGFBR1 \| DISEASES 1306 \| COL15A1 \| DISEASES 5320 \| PLA2G2A \| DISEASES 23569 \| PADI4 \| DISEASES 11240 \| PADI2 \| DISEASES 54829 \| ASPN \| DISEASES 4958 \| OMD \| DISEASES 114769 \| CARD16 \| DISEASES 6850 \| SYK \| DISEASES 283078 \| MKX \| DISEASES 3055 \| HCK \| DISEASES 10673 \| TNFSF13B \| DISEASES 3397 \| ID1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 778 \| CACNA1F \| DISEASES 1041 \| CDSN \| DISEASES 1471 \| CST3 \| DISEASES 347252 \| IGFBPL1 \| DISEASES 4609 \| MYC \| DISEASES 55301 \| OLAH \| DISEASES 414062 \| CCL3L3 \| DISEASES 6354 \| CCL7 \| DISEASES 134549 \| SHROOM1 \| DISEASES 221044 \| UCMA \| DISEASES 650 \| BMP2 \| DISEASES 79899 \| PRR5L \| DISEASES 84515 \| MCM8 \| DISEASES 55973 \| BCAP29 \| DISEASES 29103 \| DNAJC15 \| DISEASES 10549 \| PRDX4 \| DISEASES 1906 \| EDN1 \| DISEASES 22944 \| KIN \| DISEASES 10631 \| POSTN \| DISEASES 81567 \| TXNDC5 \| DISEASES 122011 \| CSNK1A1L \| DISEASES 3456 \| IFNB1 \| DISEASES 84935 \| MEDAG \| DISEASES 241 \| ALOX5AP \| DISEASES 1280 \| COL2A1 \| DISEASES 7114 \| TMSB4X \| DISEASES 57593 \| EBF4 \| DISEASES 1645 \| AKR1C1 \| DISEASES 54557 \| SGTB \| DISEASES 55020 \| TTC38 \| DISEASES 3486 \| IGFBP3 \| DISEASES 7054 \| TH \| DISEASES 55623 \| THUMPD1 \| DISEASES 90865 \| IL33 \| DISEASES 3717 \| JAK2 \| DISEASES 10522 \| DEAF1 \| DISEASES 579 \| NKX3-2 \| DISEASES 6736 \| SRY \| DISEASES 11173 \| ADAMTS7 \| DISEASES 283659 \| PRTG \| DISEASES 80070 \| ADAMTS20 \| DISEASES 284297 \| SSC5D \| DISEASES 406 \| ARNTL \| DISEASES 23143 \| LRCH1 \| DISEASES 352909 \| DNAAF3 \| DISEASES 3903 \| LAIR1 \| DISEASES 11009 \| IL24 \| DISEASES 51429 \| SNX9 \| DISEASES 10203 \| CALCRL \| DISEASES 9244 \| CRLF1 \| DISEASES 2113 \| ETS1 \| DISEASES 12 \| SERPINA3 \| DISEASES 78996 \| C7orf49 \| DISEASES 347734 \| SLC35B2 \| DISEASES 3886 \| KRT35 \| DISEASES 6152 \| RPL24 \| DISEASES 9862 \| MED24 \| DISEASES 200894 \| ARL13B \| DISEASES 5627 \| PROS1 \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 6355 \| CCL8 \| DISEASES 3426 \| CFI \| DISEASES 6164 \| RPL34 \| DISEASES 100131390 \| SP9 \| DISEASES 6696 \| SPP1 \| DISEASES 81606 \| LBH \| DISEASES 2919 \| CXCL1 \| DISEASES 6387 \| CXCL12 \| DISEASES 655 \| BMP7 \| DISEASES 5744 \| PTHLH \| DISEASES 4773 \| NFATC2 \| DISEASES 117195 \| MRGPRX3 \| DISEASES 26993 \| AKAP8L \| DISEASES 5609 \| MAP2K7 \| DISEASES 594857 \| NPS \| DISEASES 7110 \| TMF1 \| DISEASES 56099 \| PCDHGB7 \| DISEASES 84444 \| DOT1L \| DISEASES 7478 \| WNT8A \| DISEASES 7442 \| TRPV1 \| DISEASES 57708 \| MIER1 \| DISEASES 4148 \| MATN3 \| DISEASES 79174 \| CRELD2 \| DISEASES 5970 \| RELA \| DISEASES 55120 \| FANCL \| DISEASES 8995 \| TNFSF18 \| DISEASES 84268 \| RPAIN \| DISEASES 7018 \| TF \| DISEASES 6335 \| SCN9A \| DISEASES 7852 \| CXCR4 \| DISEASES 80146 \| UXS1 \| DISEASES 176 \| ACAN \| DISEASES 340351 \| AGBL3 \| DISEASES 3384 \| ICAM2 \| DISEASES 5601 \| MAPK9 \| DISEASES 6916 \| TBXAS1 \| DISEASES 23109 \| DDN \| DISEASES 6336 \| SCN10A \| DISEASES 2086 \| ERV3-1 \| DISEASES 163131 \| ZNF780B \| DISEASES 3481 \| IGF2 \| DISEASES 6399 \| TRAPPC2 \| DISEASES 2260 \| FGFR1 \| DISEASES 197 \| AHSG \| DISEASES 83700 \| JAM3 \| DISEASES 26354 \| GNL3 \| DISEASES 10725 \| NFAT5 \| DISEASES 720 \| C4A \| DISEASES 6660 \| SOX5 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 3491 \| CYR61 \| DISEASES 3109 \| HLA-DMB \| DISEASES 10216 \| PRG4 \| DISEASES 387 \| RHOA \| DISEASES 4615 \| MYD88 \| DISEASES 64084 \| CLSTN2 \| DISEASES 26054 \| SENP6 \| DISEASES 4049 \| LTA \| DISEASES 7086 \| TKT \| DISEASES 388372 \| CCL4L1 \| DISEASES 91833 \| WDR20 \| DISEASES 9060 \| PAPSS2 \| DISEASES 162466 \| PHOSPHO1 \| DISEASES 54900 \| LAX1 \| DISEASES 7148 \| TNXB \| DISEASES 6349 \| CCL3L1 \| DISEASES 1154 \| CISH \| DISEASES 834 \| CASP1 \| DISEASES 6424 \| SFRP4 \| DISEASES 4140 \| MARK3 \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 57553 \| MICAL3 \| DISEASES 6513 \| SLC2A1 \| DISEASES 3077 \| HFE \| DISEASES 3712 \| IVD \| DISEASES 56999 \| ADAMTS9 \| DISEASES 6256 \| RXRA \| DISEASES 6452 \| SH3BP2 \| DISEASES 134145 \| FAM173B \| DISEASES 81792 \| ADAMTS12 \| DISEASES 2920 \| CXCL2 \| DISEASES 90161 \| HS6ST2 \| DISEASES 100287362 \| PRSS46 \| DISEASES 3551 \| IKBKB \| DISEASES 4914 \| NTRK1 \| DISEASES 113174 \| SAAL1 \| DISEASES 56 \| ACRV1 \| DISEASES 56413 \| LTB4R2 \| DISEASES 26298 \| EHF \| DISEASES 23263 \| MCF2L \| DISEASES 3684 \| ITGAM \| DISEASES 11331 \| PHB2 \| DISEASES 5027 \| P2RX7 \| DISEASES 91 \| ACVR1B \| DISEASES 11153 \| FICD \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 1649 \| DDIT3 \| DISEASES 1734 \| DIO2 \| DISEASES 3892 \| KRT86 \| DISEASES 567 \| B2M \| DISEASES 11243 \| PMF1 \| DISEASES 10143 \| CLEC3A \| DISEASES 64772 \| ENGASE \| DISEASES 8792 \| TNFRSF11A \| DISEASES 9141 \| PDCD5 \| DISEASES 284424 \| MIR7-3HG \| DISEASES 5608 \| MAP2K6 \| DISEASES 594842 \| HAS2-AS1 \| DISEASES 106144538 \| KCNK15-AS1 \| DISEASES 26783 \| SNORA65 \| DISEASES 692084 \| SNORD13 \| DISEASES 728723 \| ZBED3-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	283
Disease	osteoarthritis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:2) HP:0002644 \| Abnormal shape of pelvic girdle bone HP:0008843 \| Hip osteoarthritis
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:100) HP:0012531 \| Pain \| 316 HP:0012532 \| Chronic pain \| 39 HP:0030839 \| Knee pain \| 29 HP:0001513 \| Obesity \| 20 HP:0002829 \| Arthralgias \| 15 HP:0010885 \| Aseptic necrosis \| 10 HP:0003418 \| Back pain \| 9 HP:0005086 \| Knee osteoarthritis \| 8 HP:0001369 \| Arthritis \| 7 HP:0100769 \| Synovitis \| 6 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0000716 \| Depression \| 5 HP:0000819 \| Diabetes mellitus \| 5 HP:0003419 \| Low back pain \| 5 HP:0000822 \| Hypertension \| 5 HP:0003040 \| Arthropathy \| 5 HP:0030838 \| Hip pain \| 4 HP:0001385 \| Congenital hip dysplasia \| 4 HP:0001324 \| Muscular weakness \| 4 HP:0008807 \| Dysplastic acetabulae \| 4 HP:0030883 \| Femoroacetabular Impingement \| 4 HP:0003416 \| Spinal canal stenosis \| 3 HP:0002527 \| Falls \| 3 HP:0000939 \| Osteoporosis \| 3 HP:0003287 \| Abnormality of mitochondrial metabolism \| 3 HP:0002999 \| Dislocated kneecap \| 3 HP:0002857 \| Genu valgum \| 3 HP:0100773 \| Cartilage destruction \| 3 HP:0001387 \| Stiff joints \| 3 HP:0004936 \| Blood clot in vein \| 2 HP:0003731 \| Quadriceps weakness \| 2 HP:0002625 \| Blood clot in a deep vein \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0030833 \| Neck pain \| 2 HP:0012032 \| Lipoma \| 2 HP:0002812 \| Coxa vara \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0004610 \| Narrow lumbar spinal canal \| 2 HP:0004976 \| Dislocations of the knees \| 2 HP:0002797 \| Increased bone resorption \| 2 HP:0001371 \| Flexion contractures of joints \| 2 HP:0000821 \| Underactive thyroid \| 2 HP:0030834 \| Shoulder pain \| 2 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0008826 \| Dislocated femoral heads \| 1 HP:0100022 \| Movement disorder \| 1 HP:0002653 \| Bone pain \| 1 HP:0005186 \| Synovial hypertrophy \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0100550 \| Rupture of tendons \| 1 HP:0200042 \| Skin ulcer \| 1 HP:0001903 \| Anemia \| 1 HP:0012533 \| Allodynia \| 1 HP:0002659 \| Increased tendency to fractures \| 1 HP:0001997 \| Gout \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0001376 \| Decreased joint mobility \| 1 HP:0002094 \| Dyspnea \| 1 HP:0001289 \| Confusion \| 1 HP:0003304 \| Spondylolysis \| 1 HP:0001822 \| Hallux valgus \| 1 HP:0000845 \| Acromegalic growth \| 1 HP:0010807 \| Open bite between upper and lower teeth \| 1 HP:0011001 \| Increased bone mineral density \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0012743 \| Central obesity \| 1 HP:0001379 \| Degenerative joint disease \| 1 HP:0001762 \| Talipes equinovarus \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0002656 \| Epiphyseal dysplasia \| 1 HP:0008419 \| Degeneration of intervertebral disks \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0002655 \| Spondyloepiphyseal dysplasia \| 1 HP:0003467 \| Atlantoaxial instability \| 1 HP:0002650 \| Scoliosis \| 1 HP:0002315 \| Headaches \| 1 HP:0100785 \| Insomnia \| 1 HP:0200095 \| Anterior open bite \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0002025 \| Narrowing of anal opening \| 1 HP:0011002 \| Osteopetrosis \| 1 HP:0030836 \| Wrist pain \| 1 HP:0009027 \| Foot drop \| 1 HP:0100033 \| Tic disorder \| 1 HP:0000734 \| Disinhibition \| 1 HP:0009763 \| Limb pain \| 1 HP:0030840 \| Ankle pain \| 1 HP:0001388 \| Joint laxity \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0001681 \| Angina pectoris \| 1 HP:0002938 \| Exaggerated lumbar lordosis \| 1 HP:0012378 \| Fatigue \| 1 HP:0012062 \| Bone cysts \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0000934 \| Chondrocalcinosis \| 1 HP:0012399 \| Bedsore \| 1 HP:0001386 \| Joint swelling \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0000969 \| Dropsy \| 1

Disease ID	283
Disease	osteoarthritis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:28) C0030193 \| pain \| 316 C0150055 \| chronic pain \| 39 C0231749 \| knee pain \| 29 C0028754 \| obesity \| 20 C0427008 \| stiffness \| 17 C0003862 \| joint pain \| 14 C1956089 \| osteophytes \| 8 C0007222 \| cardiovascular disease \| 7 C0039103 \| synovitis \| 6 C0278140 \| severe pain \| 6 C0796095 \| c syndrome \| 6 C0311395 \| lameness \| 6 C0011570 \| depression \| 5 C0426768 \| o sign \| 5 C0004093 \| weakness \| 5 C0019559 \| hip pain \| 4 C0029408 \| joint degeneration \| 4 C0029456 \| osteoporosis \| 3 C0042870 \| vitamin d deficiency \| 2 C0030567 \| parkinson's disease \| 2 C0022408 \| joint disease \| 2 C0040053 \| thrombosis \| 2 C0278139 \| moderate pain \| 1 C0231749 \| knee joint pain \| 1 C0029408 \| degenerative joint disease \| 1 C0577655 \| quadriceps weakness \| 1 C0015672 \| fatigue \| 1 C0086132 \| depressive symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:70)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061622	16871413	7133	TNFRSF1B	umls:C0029408	BeFree	Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.	0.003181358	2006	TNFRSF1B	1	12192898	T	G
rs1062033	20417295	1588	CYP19A1	umls:C0029408	BeFree	The rs1062033 genotype associated with higher OA risk was also associated with reduced expression of the aromatase gene in bone.	0.005634266	2010	CYP19A1;PIRC66	15	51255741	C	G
rs10948172	22763110	8464	SUPT3H	umls:C0029408	GWASCAT	Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.	0.12	2012	SUPT3H;LOC101929770	6	44809954	A	G
rs10980705	18625619	1902	LPAR1	umls:C0029408	BeFree	To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2).	0.001085767	2009	LPAR1	9	111040905	C	T
rs10980705	18625619	79513	OR10R1P	umls:C0029408	BeFree	The association of the rs10980705 SNP with knee OA was not replicated in any of the five sample collections studied or in their combined analysis (odds ratio (OR) 1.10, 95% CI 0.98 to 1.22; p = 0.10).	0.000271442	2009	LPAR1	9	111040905	C	T
rs10980705	18325907	1902	LPAR1	umls:C0029408	BeFree	Through the stepwise association study, an SNP located in the promoter region of EDG2 [endothelial differentiation, lysophosphatidic acid (LPA) GPCR, 2] (-2,820G/A; rs10980705) showed significant association with knee OA in two independent populations (pooled P = 2.6 x 10(-5)).	0.001085767	2008	LPAR1	9	111040905	C	T
rs11177	22763110	692089	SNORD19	umls:C0029408	GWASCAT	Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.	0.12	2012	GNL3;PBRM1;SNORD19;SNORD136	3	52687289	G	A
rs11177	22763110	55193	PBRM1	umls:C0029408	GWASCAT	Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.	0.12	2012	GNL3;PBRM1;SNORD19;SNORD136	3	52687289	G	A
rs11177	22763110	26354	GNL3	umls:C0029408	GWASCAT	Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies.	0.120542884	2012	GNL3;PBRM1;SNORD19;SNORD136	3	52687289	G	A
rs1143627	19733643	3557	IL1RN	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.025808179	2010	IL1B	2	112836810	G	A
rs1143627	19733643	3553	IL1B	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.255554621	2010	IL1B	2	112836810	G	A
rs1143634	23216199	3557	IL1RN	umls:C0029408	BeFree	Haplotype analyses revealed gender disparities and showed that women carriers of the 1-2-1-1 haplotype [IL-1A(rs1800587) - IL-1B(rs1143634) - IL-1B(rs16944) - IL-1RN(VNTR)] had sixfold lower risk to develop knee OA.	0.025808179	2013	IL1B	2	112832813	G	A
rs11564299	24148886	3190	HNRNPK	umls:C0029408	BeFree	In summary, a CDH2 promoter polymorphism influences the risk of OA, and hnRNP K was found to be involved in the regulation of elevated N-cadherin expression in patients with OA carrying the minor allele of rs11564299.	0.000271442	2014	NA	18	28180064	A	G
rs116855380	26211391	8202	NCOA3	umls:C0029408	BeFree	Correlation of the osteoarthritis susceptibility variants that map to chromosome 20q13 with an expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism rs116855380.	0.000814326	2015	NA	20	47491550	A	G
rs11842874	21871595	23263	MCF2L	umls:C0029408	GWASCAT	A variant in MCF2L is associated with osteoarthritis.	0.120814326	2011	MCF2L	13	113040195	A	G
rs12149832	22956599	79068	FTO	umls:C0029408	BeFree	However, only one of the height or BMI signals that had shown evidence of association with osteoarthritis in the arcOGEN GWAS was also associated with osteoarthritis in the independent dataset: rs12149832, within the FTO gene (combined p=2.3×10(-5)).	0.000814326	2013	FTO	16	53808996	G	A
rs1256049	21523342	2100	ESR2	umls:C0029408	BeFree	To investigate the possible influence of the single nucleotide polymorphism (SNP) of the estrogen receptor-β gene, rs1256049 (Rsa) in exon 5, on the frequency of rheumatoid arthritis (RA), 263 RA patients and 174 control subjects with osteoarthritis (OA) were recruited.	0.005819831	2012	ESR2	14	64257333	C	T
rs1256049	23352710	2100	ESR2	umls:C0029408	BeFree	The rs1256049 polymorphism of the estrogen receptor-β gene can potentially be used to identify genetically high-risk subgroup of osteoarthritis in advance and to understand pathogenesis of osteoarthritis.	0.005819831	2012	ESR2	14	64257333	C	T
rs12885713	18452398	805	CALM2	umls:C0029408	BeFree	Our data implied that the -16TT (rs12885713) CALM1 core promoter genotype is not a risk factor for OA etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility.	0.001900093	2008	CALM1	14	90397013	C	A,T
rs12885713	18452398	54829	ASPN	umls:C0029408	BeFree	Our data implied that the -16TT (rs12885713) CALM1 core promoter genotype is not a risk factor for OA etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility.	0.156891145	2008	CALM1	14	90397013	C	A,T
rs12982744	22566624	84444	DOT1L	umls:C0029408	GWASCAT	DOT1L may represent a therapeutic target for OA.	0.120542884	2012	DOT1L	19	2177194	C	G
rs143383	18947434	8200	GDF5	umls:C0029408	BeFree	A functional single nucleotide polymorphism (SNP) in the 5'-untranslated region of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility.	0.151061383	2008	GDF5	20	35438203	G	A
rs143383	17676627	8200	GDF5	umls:C0029408	BeFree	Our data implied that the +104T/C; rs143383 GDF5 core promoter polymorphism is not a risk factor for OA etiology in Greek Caucasians.	0.151061383	2008	GDF5	20	35438203	G	A
rs143383	20633687	8200	GDF5	umls:C0029408	BeFree	Recently, a functional polymorphism (rs143383) of the 5'-untranslated region of GDF5 (Growth/Differentiation Factor 5) - previously reported to be associated with osteoarthritis - has been associated with CDH in a Chinese population.	0.151061383	2010	GDF5	20	35438203	G	A
rs143383	25456297	8200	GDF5	umls:C0029408	BeFree	The discovery of a novel variant near the NCOA3 (nuclear receptor coactivator 3) gene associated with hip OA and the regulation of GDF5 gene by four transcription factors via the OA susceptibility locus rs143383 are among important findings in OA genetics.	0.151061383	2014	GDF5	20	35438203	G	A
rs143383	24861163	8200	GDF5	umls:C0029408	BeFree	CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383.	0.151061383	2014	GDF5	20	35438203	G	A
rs143383	25456297	8202	NCOA3	umls:C0029408	BeFree	The discovery of a novel variant near the NCOA3 (nuclear receptor coactivator 3) gene associated with hip OA and the regulation of GDF5 gene by four transcription factors via the OA susceptibility locus rs143383 are among important findings in OA genetics.	0.000814326	2014	GDF5	20	35438203	G	A
rs143383	23825960	8200	GDF5	umls:C0029408	BeFree	The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.	0.151061383	2013	GDF5	20	35438203	G	A
rs16944	19733643	3553	IL1B	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.255554621	2010	IL1B	2	112837290	A	G
rs16944	19733643	3557	IL1RN	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.025808179	2010	IL1B	2	112837290	A	G
rs16944	23216199	3557	IL1RN	umls:C0029408	BeFree	Haplotype analyses revealed gender disparities and showed that women carriers of the 1-2-1-1 haplotype [IL-1A(rs1800587) - IL-1B(rs1143634) - IL-1B(rs16944) - IL-1RN(VNTR)] had sixfold lower risk to develop knee OA.	0.025808179	2013	IL1B	2	112837290	A	G
rs1799945	17284543	3077	HFE	umls:C0029408	BeFree	The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis.	0.021279544	2007	HFE	6	26090951	C	G
rs1799945	16755236	3077	HFE	umls:C0029408	BeFree	Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype.	0.021279544	2006	HFE	6	26090951	C	G
rs1800562	22209421	3077	HFE	umls:C0029408	BeFree	HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis.	0.021279544	2012	HFE	6	26092913	G	A
rs1800562	12508400	3077	HFE	umls:C0029408	BeFree	This is the first report to show an increased risk of OA among individuals who are heterozygous for the C282Y HFE mutation.	0.021279544	2003	HFE	6	26092913	G	A
rs1800587	23216199	3557	IL1RN	umls:C0029408	BeFree	Haplotype analyses revealed gender disparities and showed that women carriers of the 1-2-1-1 haplotype [IL-1A(rs1800587) - IL-1B(rs1143634) - IL-1B(rs16944) - IL-1RN(VNTR)] had sixfold lower risk to develop knee OA.	0.025808179	2013	IL1A	2	112785383	G	C,A
rs1800587	15077300	3552	IL1A	umls:C0029408	GAD	[To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine.]	0.028436721	2004	IL1A	2	112785383	G	C,A
rs1871054	25197389	8038	ADAM12	umls:C0029408	BeFree	In conclusion, our data demonstrated the ADAM12 rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.	0.006362715	2014	ADAM12	10	126093840	C	T
rs1871054	25667922	8038	ADAM12	umls:C0029408	BeFree	In summary, we have identified that the rs1871054 variant within the ADAM12 gene is a risk factor for increased osteoarthritis susceptibility and severity.	0.006362715	2014	ADAM12	10	126093840	C	T
rs20417	20378913	5743	PTGS2	umls:C0029408	BeFree	The promoter polymorphism rs20417 of the COX-2 gene contributes to the genetic risk for end-stage hip and knee OA.	0.009695963	2011	PTGS2;PACERR	1	186681189	C	G
rs2070739	21088911	1280	COL2A1	umls:C0029408	BeFree	To investigate the relationships between two COL2A1 single nucleotide polymorphisms (SNPs; T2088C and G4006A) and osteoarthritis (OA) in Han Chinese women.	0.231789832	2011	COL2A1	12	47974193	C	T
rs225014	22492780	1734	DIO2	umls:C0029408	BeFree	The allelic imbalance of the DIO2 mRNA transcript, with the OA risk allele 'C' of rs225014 more abundant than the wild-type 'T' allele in heterozygote carriers provides a possible mechanism by which genetic variation at DIO2 confers OA risk.	0.009087065	2012	DIO2	14	80203237	T	C
rs2276454	21088911	1280	COL2A1	umls:C0029408	BeFree	To investigate the relationships between two COL2A1 single nucleotide polymorphisms (SNPs; T2088C and G4006A) and osteoarthritis (OA) in Han Chinese women.	0.231789832	2011	COL2A1;LOC105369752	12	47982508	G	A
rs2276455	19019890	1280	COL2A1	umls:C0029408	BeFree	To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women.	0.231789832	2009	COL2A1;LOC105369752	12	47982354	G	A
rs288326	16572458	2487	FRZB	umls:C0029408	BeFree	Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA.	0.26507973	2006	FRZB	2	182838608	G	A
rs288326	NA	2487	FRZB	umls:C0029408	CLINVAR	NA	0.26507973	NA	FRZB	2	182838608	G	A
rs28939676	20971668	4148	MATN3	umls:C0029408	BeFree	The T303M polymorphism of the MATN3 gene, which was initially described as associated with hand osteoarthritis, may be more closely linked to trapeziometacarpal osteoarthritis than to digital osteoarthritis.	0.129901391	2011	NA	NA	NA	NA	NA
rs3117582	25231575	55603	FAM46A	umls:C0029408	BeFree	Family with sequence similarity 46, member A (FAM46A) gene VNTR and BCL2-Associated Athanogene 6 (BAG6) gene rs3117582 polymorphisms were genotyped in a case-control study with 474 large-joint (hip and knee) osteoarthritis (OA) patients and 568 controls in Croatian population by candidate-gene approach for association with OA.	0.000271442	2014	BAG6;APOM	6	31652743	T	G
rs3117582	25231575	7917	BAG6	umls:C0029408	BeFree	Family with sequence similarity 46, member A (FAM46A) gene VNTR and BCL2-Associated Athanogene 6 (BAG6) gene rs3117582 polymorphisms were genotyped in a case-control study with 474 large-joint (hip and knee) osteoarthritis (OA) patients and 568 controls in Croatian population by candidate-gene approach for association with OA.	0.002638474	2014	BAG6;APOM	6	31652743	T	G
rs3204689	24728293	8854	ALDH1A2	umls:C0029408	GWASCAT	Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.	0.240271442	2014	ALDH1A2	15	57954604	G	C
rs3730043	23089924	1636	ACE	umls:C0029408	BeFree	MTHFR gene C677T mutation and ACE gene I/D polymorphism in Turkish patients with osteoarthritis.	0.000814326	2013	ACE	17	63491216	C	T
rs3737548	19019890	1280	COL2A1	umls:C0029408	BeFree	To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women.	0.231789832	2009	COL2A1;LOC105369751	12	47997633	G	T,A
rs3757837	23989986	816	CAMK2B	umls:C0029408	GWASCAT	A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.	0.12	2014	CAMK2B	7	44237052	T	C
rs3815148	20112360	10466	COG5	umls:C0029408	GAD	[The C allele of rs3815148 on chromosome 7q22 (minor allele frequency 23%; intron 12 of the COG5 gene) was associated with a 1.14-fold increased risk (95% confidence interval 1.09-1.19) of knee and/or hand OA (P = 8 x 10(-8)) and also with a 30% increased risk of knee OA progression (95% confidence interval 1.03-1.64) (P = 0.03).]	0.122909916	2010	COG5	7	107297975	A	C
rs3815148	20112360	10466	COG5	umls:C0029408	BeFree	The C allele of rs3815148 on chromosome 7q22 (minor allele frequency 23%; intron 12 of the COG5 gene) was associated with a 1.14-fold increased risk (95% confidence interval 1.09-1.19) of knee and/or hand OA (P = 8 x 10(-8)) and also with a 30% increased risk of knee OA progression (95% confidence interval 1.03-1.64) (P = 0.03).	0.122909916	2010	COG5	7	107297975	A	C
rs3815148	20112360	10466	COG5	umls:C0029408	GWASCAT	The C allele of rs3815148 on chromosome 7q22 (minor allele frequency 23%; intron 12 of the COG5 gene) was associated with a 1.14-fold increased risk (95% confidence interval 1.09-1.19) of knee and/or hand OA (P = 8 x 10(-8)) and also with a 30% increased risk of knee OA progression (95% confidence interval 1.03-1.64) (P = 0.03).	0.122909916	2010	COG5	7	107297975	A	C
rs386563303	21088911	1280	COL2A1	umls:C0029408	BeFree	To investigate the relationships between two COL2A1 single nucleotide polymorphisms (SNPs; T2088C and G4006A) and osteoarthritis (OA) in Han Chinese women.	0.231789832	2011	NA	NA	NA	NA	NA
rs4140564	18471798	5321	PLA2G4A	umls:C0029408	BeFree	rs4140564 on chromosome 1 mapping 5' to both the PTGS2 and PLA2G4A genes was associated with risk of knee OA in all the cohorts studied (overall odds ratio OR(mh) = 1.55 95% C.I.	0.003267234	2008	NA	1	186755871	G	A
rs419598	19733643	3557	IL1RN	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.025808179	2010	IL1RN	2	113129630	T	C
rs419598	19733643	3553	IL1B	umls:C0029408	BeFree	A 3-single-nucleotide polymorphism (SNP) IL1B-IL1RN haplotype rs1143627-rs16944-rs419598 showed a trend toward hand OA association (posterior probability of association 0.72) with the most prominent feature being protection from a specific haplotype representing a partial mirror image of the extended risk haplotype (OR estimated at 0.46).	0.255554621	2010	IL1RN	2	113129630	T	C
rs4730250	21068099	11062	DUS4L	umls:C0029408	GWASCAT	Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.	0.120271442	2011	DUS4L	7	107567250	A	G
rs4747096	24301791	140766	ADAMTS14	umls:C0029408	BeFree	In conclusion, the nsSNP rs4747096 in ADAMTS14 was associated with knee OA in female Thai patients; therefore, the role of ADAMTS14 in OA seems to be gender-dependent.	0.000542884	2015	ADAMTS14	10	70758253	A	G,T
rs479632	20054692	5307	PITX1	umls:C0029408	BeFree	The present study suggests that the PITX1 polymorphism (rs479632) is not a risk factor for knee OA susceptibility in the Chinese Han population.	0.000542884	2011	PITX1	5	135028828	C	G
rs5743836	21748790	7099	TLR4	umls:C0029408	BeFree	Our data demonstrated a lack of association among TLR-2, TLR-4, and TLR-9 (T-1237C) polymorphisms and the risk of developing OA in both stages of the study.	0.001900093	2012	TLR9	3	52226766	A	G
rs6094710	26211391	55959	SULF2	umls:C0029408	BeFree	To functionally characterize the osteoarthritis (OA) susceptibility variants that map to a region of high linkage disequilibrium (LD) on chromosome 20q13 marked by the single-nucleotide polymorphism (SNP) rs6094710 and encompassing NCOA3 and SULF2.	0.003538676	2015	NA	20	47466905	G	A
rs7639618	22083612	344875	COL6A4P1	umls:C0029408	BeFree	The aim of this study was to examine a single-nucleotide polymorphism (SNP) rs7639618 of double von Willebrand factor (DVWA) gene for the association with osteoarthritis (OA) susceptibility in Korean cohort.	0.001628651	2013	COL6A4P1	3	15174922	C	T
rs7775	16572458	2487	FRZB	umls:C0029408	BeFree	Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA.	0.26507973	2006	FRZB	2	182834857	G	T,C,A
rs7775	NA	2487	FRZB	umls:C0029408	CLINVAR	NA	0.26507973	NA	FRZB	2	182834857	G	T,C,A
rs7958311	22447075	5027	P2RX7	umls:C0029408	BeFree	Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, we observed a genetic association between lower pain intensity and the hypofunctional His270 (rs7958311) allele of P2RX7.	0.000542884	2012	P2RX7;LOC105370032	12	121167552	G	A,C,T
rs9340799	25325995	2099	ESR1	umls:C0029408	BeFree	Association of rs9340799 polymorphism in estrogen receptor alpha gene with the risk of osteoarthritis: evidence based on 8,792 subjects.	0.023636644	2014	ESR1	6	151842246	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:526)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	15546825	rs549	A	G	rs549	19508968	1.60E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	TMEM51
1	18278257	rs673567	G	A	rs673567	21177295	4.89E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	18278257	rs673567	G	A	rs673567	21177295	8.00E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	22523727	rs2744718	T	C	rs2744718	21177295	2.88E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
1	22523727	rs2744718	T	C	rs2744718	21177295	3.66E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
1	31272051	rs12063364	A	G	rs12063364	19508968	2.37E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	40290011	rs11206937	A	G	rs11206937	22566624	7.30E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	40555321	rs3131651	C	T	rs3131651	21177295	1.44E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PPT1
1	40555321	rs3131651	C	T	rs3131651	21177295	3.33E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PPT1
1	40555321	rs3131651	C	T	rs3131651	21177295	3.50E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PPT1
1	46805222	rs4660344	A	G	rs4660344	21177295	2.24E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
1	46805222	rs4660344	A	G	rs4660344	21177295	2.25E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
1	46805222	rs4660344	A	G	rs4660344	21177295	6.80E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
1	49064097	rs11583036	T	C	rs11583036	21177295	2.67E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	AGBL4
1	49064097	rs11583036	T	C	rs11583036	21177295	2.70E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	AGBL4
1	49064097	rs11583036	T	C	rs11583036	21177295	3.11E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	AGBL4
1	49067379	rs319978	C	T	rs319978	21177295	1.45E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	AGBL4
1	49067379	rs319978	C	T	rs319978	21177295	1.70E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	AGBL4
1	49067379	rs319978	C	T	rs319978	21177295	7.74E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	AGBL4
1	68757334	rs3923451	C	T	rs3923451	21177295	4.40E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
1	68757334	rs3923451	C	T	rs3923451	21177295	4.91E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
1	71127061	rs1334995	A	G	rs1334995	19508968	2.29E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	71142202	rs2782763	T	C	rs2782763	19508968	2.38E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
1	102274276	rs1854169	C	T	rs1854169	22763110	6.53E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
1	103452392	rs2615977	A	C	rs2615977	21177295	3.88E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	COL11A1
1	103452392	rs2615977	A	C	rs2615977	21177295	9.91E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	COL11A1
1	145674825	rs112745056	T	A	rs112745056	21871595	3.49E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
1	163762232	rs4657305	T	C	rs4657305	21177295	1.16E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
1	163762232	rs4657305	T	C	rs4657305	21177295	7.16E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
1	167589943	rs1229403	T	C	rs1229403	21177295	4.78E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	181109478	rs881964	C	T	rs881964	21177295	2.51E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	181109478	rs881964	C	T	rs881964	21177295	4.79E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
1	186725003	rs4140564	G	A	rs4140564	18471798	3.00E-06		1.59	[1.31-1.94]	357 cases; 285 controls	NOPOP(642)	ALL(642)	NOPOP(642)	ALL(642)	Knee osteoarthritis	HPOID:0005086	Knee osteoarthritis	DOID:8398	osteoarthritis	D020370	Osteoarthritis, Knee	EFOID:0004616	osteoarthritis of the knee	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
1	201976402	rs2819358	T	G	rs2819358	21177295	5.58E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LOC100289488
1	201976402	rs2819358	T	G	rs2819358	21177295	6.13E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LOC100289488
1	208049077	rs2952	C	T	rs2952	21177295	2.33E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
1	208049077	rs2952	C	T	rs2952	21177295	4.74E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
1	219673828	rs1417066	G	A	rs1417066	22763110	1.00E-06	NA	1.07	[1.04-1.10]	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs1417066-G	Multicenter Study	Research Support, Non-U.S. Gov't	C
1	225685928	rs1629896	A	G	rs1629896	22763110	4.82E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
1	244809936	rs987179	G	A	rs987179	22763110	6.23E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
1	246898134	rs7526237	C	T	rs7526237	21177295	1.23E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	SCCPDH
1	246898134	rs7526237	C	T	rs7526237	21177295	3.76E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	SCCPDH
1	246898134	rs7526237	C	T	rs7526237	21177295	4.53E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	SCCPDH
2	10059654	rs112736747	C	G	rs112736747	21871595	7.16E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
2	37601208	rs1024816	A	G	rs1024816	22763110	1.72E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
2	52042513	rs7603003	A	G	rs7603003	21177295	2.88E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
2	52042513	rs7603003	A	G	rs7603003	21177295	4.18E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
2	56096892	rs3791679	A	G	rs3791679	22763110	1.71E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
2	60449710	rs1473099	A	G	rs1473099	19508968	8.83E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
2	74755778	rs10779958	A	C	rs10779958	22763110	2.97E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
2	77712607	rs1922817	G	T	rs1922817	19508968	2.80E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	LRRTM4
2	81191209	rs4462808	G	T	rs4462808	19508968	1.31E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
2	81201683	rs4389353	C	T	rs4389353	19508968	3.37E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
2	106454085	rs7589561	C	T	rs7589561	21177295	2.02E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NCK2
2	106454085	rs7589561	C	T	rs7589561	21177295	5.53E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NCK2
2	109156275	rs6754683	G	A	rs6754683	22763110	8.84E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
2	125806843	rs4622728	T	C	rs4622728	22763110	6.22E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
2	137808507	rs1432237	A	G	rs1432237	22763110	4.44E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
2	151732979	rs12618428	A	G	rs12618428	22763110	7.72E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
2	163894302	rs918932	C	T	rs918932	21177295	5.08E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
2	165928113	rs62174866	A	T	rs62174866	21871595	6.65E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
2	165929310	rs62174867	C	T	rs62174867	21871595	6.65E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
2	165930578	rs62174869	C	G	rs62174869	21871595	3.44E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
2	165936973	rs62174894	G	A	rs62174894	21871595	6.54E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
2	165958651	rs62174897	A	G	rs62174897	21871595	1.41E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
2	165988343	rs62174901	T	C	rs62174901	21871595	9.01E-07	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	166008357	rs62174906	A	G	rs62174906	21871595	6.66E-07	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
2	175542474	rs6716254	T	C	rs6716254	22763110	8.05E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
2	182344221	rs3770123	A	C	rs3770123	21871595	5.21E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	182352568	rs10172410	T	C	rs10172410	21871595	2.90E-07	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	206150594	rs1207421	A	G	rs1207421	18471798	6.00E-06		1.46	[1.24-1.73]	357 cases; 285 controls	NOPOP(642)	ALL(642)	NOPOP(642)	ALL(642)	Knee osteoarthritis	HPOID:0005086	Knee osteoarthritis	DOID:8398	osteoarthritis	D020370	Osteoarthritis, Knee	EFOID:0004616	osteoarthritis of the knee	Arthritis	NA	Research Support, Non-U.S. Gov't	C	PARD3B
2	206614091	rs13026243	T	G	rs13026243	21177295	1.79E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NRP2
2	206614091	rs13026243	T	G	rs13026243	21177295	3.18E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NRP2
2	206614091	rs13026243	T	G	rs13026243	21177295	3.37E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NRP2
2	211024197	rs4673501	A	G	rs4673501	21177295	2.47E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	KANSL1L
2	211024197	rs4673501	A	G	rs4673501	21177295	4.49E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	KANSL1L
2	211024197	rs4673501	A	G	rs4673501	21177295	6.29E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	KANSL1L
2	211761578	rs13013804	A	G	rs13013804	19508968	1.94E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
2	229332491	rs2059390	A	G	rs2059390	21177295	3.02E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
2	229332491	rs2059390	A	G	rs2059390	21177295	3.22E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
3	6478949	rs2124811	A	G	rs2124811	19508968	1.11E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
3	8826396	rs6793234	A	G	rs6793234	22763110	6.86E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
3	15216429	rs7639618	C	T	rs7639618	18622395	7.30E-11	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	C	NA
3	15224983	rs353093	C	T	rs353093	18622395	6.20E-05	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	C	COL6A4P1
3	15227252	rs9864422	C	T	rs9864422	18622395	2.40E-08	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	T	COL6A4P1
3	15247796	rs1287464	A	G	rs1287464	18622395	6.70E-05	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	C	CAPN7
3	15264563	rs3773475	T	C	rs3773475	18622395	2.40E-05	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	G	CAPN7
3	15294811	rs11713836	G	A	rs11713836	18622395	2.10E-04	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	G	NA
3	15302753	rs3773472	G	C	rs3773472	18622395	6.50E-07	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	T	SH3BP5
3	15308240	rs3773469	A	G	rs3773469	18622395	5.40E-04	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	T	SH3BP5
3	19994475	rs4858660	G	A	rs4858660	21177295	3.12E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	RAB5A
3	25392772	rs11718836	G	A	rs11718836	18622395	5.20E-08	Knee osteoarthritis	NA	NA	94 Japanese cases; 658 Japanese controls	Japanese(752)	ALL(752)	ASN(752)	ALL(752)	Osteoarthritis (knee)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	NA	G	NA
3	39369682	rs12107527	C	T	rs12107527	21177295	2.37E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	39369682	rs12107527	C	T	rs12107527	21177295	5.83E-06	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	52721305	rs11177	G	A	rs11177	22763110	5.00E-09	NA	1.09	[1.06-1.12]	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs11177-A	Multicenter Study	Research Support, Non-U.S. Gov't	C
3	52728804	rs6976	C	T	rs6976	22763110	2.27E-10	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
3	59655530	rs10510816	C	A	rs10510816	22763110	2.34E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
3	59898057	rs294459	T	C	rs294459	21177295	4.35E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	FHIT
3	87854277	rs959132	T	C	rs959132	19508968	1.10E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
3	117346618	rs2904196	T	C	rs2904196	19508968	3.54E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
3	131487666	rs1355782	T	C	rs1355782	22763110	3.83E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
3	140842821	rs16851066	G	A	rs16851066	22763110	5.37E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
3	143269658	rs10513209	C	T	rs10513209	19508968	2.24E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	SLC9A9
3	143311453	rs17582102	T	C	rs17582102	19508968	3.61E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	SLC9A9
3	163258818	rs9841414	C	T	rs9841414	21177295	2.46E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	163258818	rs9841414	C	T	rs9841414	21177295	3.13E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	164435533	rs6548369	C	T	rs6548369	21177295	1.31E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	164435533	rs6548369	C	T	rs6548369	21177295	5.51E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
3	164863010	rs9867979	A	G	rs9867979	22763110	3.06E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
3	170171835	rs7647823	A	G	rs7647823	21177295	1.07E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
3	170171835	rs7647823	A	G	rs7647823	21177295	1.12E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
3	172193632	rs6445063	T	C	rs6445063	21760914	1.70E-04	Osteoporotic fracture (Hip fracture)	NA	NA	350 Chinese cases; 350 Chinese controls	Chinese(700)	ALL(700)	ASN(700)	ALL(700)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
3	173317852	rs16828127	T	C	rs16828127	21177295	1.22E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NLGN1
3	173317852	rs16828127	T	C	rs16828127	21177295	2.26E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NLGN1
3	173317852	rs16828127	T	C	rs16828127	21177295	3.48E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NLGN1
3	173317852	rs16828127	T	C	rs16828127	21177295	6.92E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NLGN1
3	173877136	rs7612490	C	A	rs7612490	21177295	1.57E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NLGN1
3	173877136	rs7612490	C	A	rs7612490	21177295	3.64E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NLGN1
3	173877136	rs7612490	C	A	rs7612490	21177295	6.57E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NLGN1
3	174820195	rs6443283	C	T	rs6443283	19508968	3.44E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NAALADL2
3	177997568	rs9879640	A	G	rs9879640	19508968	7.29E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
3	189600160	rs12107036	A	G	rs12107036	22763110	3.03E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
3	190350461	rs7626795	A	G	rs7626795	21177295	1.57E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	IL1RAP
3	190350461	rs7626795	A	G	rs7626795	21177295	1.73E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	IL1RAP
3	190350461	rs7626795	A	G	rs7626795	21177295	4.45E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	IL1RAP
4	5504274	rs16837352	G	T	rs16837352	22763110	3.78E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
4	6113559	rs11731332	C	T	rs11731332	19508968	2.67E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	JAKMIP1
4	37900725	rs17578878	C	T	rs17578878	22763110	9.87E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
4	48387851	rs11725992	T	C	rs11725992	22763110	7.01E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
4	54847381	rs6828100	G	A	rs6828100	21177295	5.98E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
4	60489510	rs6842739	A	G	rs6842739	22763110	7.19E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
4	76102398	rs11940311	T	C	rs11940311	19508968	2.32E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
4	76164287	rs7691721	C	T	rs7691721	19508968	7.08E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	79895323	rs10030550	G	A	rs10030550	19508968	2.31E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LOC100505875
4	80332039	rs10049840	C	A	rs10049840	19508968	2.80E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
4	96255088	rs2626053	G	A	rs2626053	22763110	6.54E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
4	106309224	rs2636726	G	A	rs2636726	22763110	8.44E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
4	114540781	rs12500935	G	A	rs12500935	22763110	4.10E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
4	118072289	rs2196712	G	A	rs2196712	21177295	1.11E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	118072289	rs2196712	G	A	rs2196712	21177295	8.54E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	165726891	rs4572830	C	T	rs4572830	21177295	5.33E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	165726891	rs4572830	C	T	rs4572830	21177295	7.24E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	186732566	rs1566347	T	C	rs1566347	22763110	9.15E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
4	188698095	rs7683009	C	T	rs7683009	21177295	3.29E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
4	188698095	rs7683009	C	T	rs7683009	21177295	3.62E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	583442	rs4957048	G	A	rs4957048	22763110	3.42E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	11589030	rs2251418	C	T	rs2251418	21177295	2.75E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	CTNND2
5	11589030	rs2251418	C	T	rs2251418	21177295	3.26E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	CTNND2
5	11589030	rs2251418	C	T	rs2251418	21177295	7.63E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	CTNND2
5	18173672	rs2443547	C	T	rs2443547	19508968	3.57E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	18176583	rs442958	A	G	rs442958	19508968	3.36E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	65149815	rs10057505	A	G	rs10057505	19508968	2.79E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	65160065	rs11948927	C	A	rs11948927	19508968	3.56E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	66278913	rs1083523	C	T	rs1083523	22763110	2.75E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	67791030	rs11738020	C	T	rs11738020	22566624	5.50E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	71256659	rs2610424	T	C	rs2610424	22763110	6.62E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
5	81074655	rs457008	C	T	rs457008	22763110	3.37E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C,T
5	89654177	rs2366614	A	G	rs2366614	21177295	1.74E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	89654177	rs2366614	A	G	rs2366614	21177295	3.29E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	89654177	rs2366614	A	G	rs2366614	21177295	3.96E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	89654177	rs2366614	A	G	rs2366614	21177295	7.41E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	91303719	rs7356540	T	C	rs7356540	19508968	3.40E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
5	91322882	rs2112945	A	G	rs2112945	19508968	1.94E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
5	91754932	rs10036746	A	G	rs10036746	22763110	9.86E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
5	93187135	rs11135394	C	T	rs11135394	22763110	9.46E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	117315725	rs6595079	C	T	rs6595079	21177295	6.72E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	117315725	rs6595079	C	T	rs6595079	21177295	7.15E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	124004404	rs13162151	G	A	rs13162151	19508968	3.04E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZNF608
5	127691233	rs32218	A	G	rs32218	19508968	2.43E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	FBN2
5	134305197	rs12515798	C	T	rs12515798	22763110	2.78E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	144812693	rs10515550	C	T	rs10515550	22763110	9.93E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	148586989	rs13167773	C	T	rs13167773	22763110	3.87E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	163382675	rs7720295	C	T	rs7720295	19508968	1.04E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
5	167822652	rs10051783	C	T	rs10051783	22763110	6.94E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
5	180656749	rs112739547	T	C	rs112739547	21871595	7.08E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	32373312	rs10947262	C	T	rs10947262	20305777	5.00E-09	NA	1.31	[1.20-1.44]	899 Japanese cases; 3,396 Japanese controls	Japanese(4295)	ALL(4295)	ASN(4295)	ALL(4295)	Knee osteoarthritis	HPOID:0005086	Knee osteoarthritis	DOID:8398	osteoarthritis	D020370	Osteoarthritis, Knee	EFOID:0004616	osteoarthritis of the knee	Arthritis	rs10947262-T	Research Support, Non-U.S. Gov't	T	BTNL2
6	41034858	rs11280	T	C	rs11280	21177295	3.23E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	C6orf130
6	41034858	rs11280	T	C	rs11280	21177295	5.94E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	C6orf130
6	44687957	rs10948155	T	C	rs10948155	22566624	7.70E-07	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
6	44777691	rs10948172	A	G	rs10948172	22763110	6.00E-07	NA	1.08	[1.05-1.12]	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs10948172-G	Multicenter Study	Research Support, Non-U.S. Gov't	A
6	73244928	rs9442813	G	A	rs9442813	19508968	1.58E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
6	76241527	rs9350591	C	T	rs9350591	22763110	2.49E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T,C
6	76357593	rs569731	G	A	rs569731	22763110	1.64E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
6	79886077	rs1577792	A	G	rs1577792	23989986	9.60E-06	NA	1.07	[1.04-1.11]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs1577792-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
6	82637934	rs9294239	C	T	rs9294239	21177295	2.35E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	LOC100506867
6	82637934	rs9294239	C	T	rs9294239	21177295	2.53E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	LOC100506867
6	82647162	rs9294240	C	T	rs9294240	21177295	5.35E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	LOC100506867
6	82647162	rs9294240	C	T	rs9294240	21177295	5.99E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	LOC100506867
6	82670520	rs9449384	C	T	rs9449384	22763110	2.19E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
6	95383492	rs2493984	A	G	rs2493984	22763110	3.25E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
6	109637154	rs7755798	T	C	rs7755798	22763110	9.87E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
6	112635196	rs2027532	T	C	rs2027532	22763110	3.72E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
6	113971591	rs6931833	G	A	rs6931833	22763110	5.92E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
6	114206311	rs503593	A	G	rs503593	21177295	1.65E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
6	153857936	rs559901	A	G	rs559901	21177295	6.24E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
6	167083690	rs6921577	A	G	rs6921577	19508968	1.09E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	RPS6KA2
6	167778498	rs12213619	T	G	rs12213619	19508968	7.88E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
7	1680165	rs12703010	C	T	rs12703010	21177295	1.53E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	1680165	rs12703010	C	T	rs12703010	21177295	4.66E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	4552959	rs1447398	G	A	rs1447398	19508968	2.69E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
7	16764996	rs17627827	A	G	rs17627827	22763110	1.71E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
7	23010063	rs6461679	T	C	rs6461679	22763110	2.67E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
7	28183702	rs849140	T	C	rs849140	21177295	2.24E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	JAZF1
7	28183702	rs849140	T	C	rs849140	21177295	2.91E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	JAZF1
7	28183702	rs849140	T	C	rs849140	21177295	5.46E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	JAZF1
7	29145706	rs1522919	A	G	rs1522919	19508968	2.94E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	CPVL
7	29434444	rs1034716	A	G	rs1034716	19508968	3.15E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	CHN2
7	31522092	rs4720038	C	A	rs4720038	21177295	1.88E-07	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	31522092	rs4720038	C	A	rs4720038	21177295	3.50E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	31522092	rs4720038	C	A	rs4720038	21177295	5.68E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	32461015	rs7785659	C	T	rs7785659	22763110	1.37E-08	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
7	32573570	rs7805536	T	C	rs7805536	22763110	4.38E-08	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
7	44276651	rs3757837	T	C	rs3757837	23989986	8.00E-10	Male-specifc	1.27	[1.15-1.41]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs3757837-C	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
7	44354257	rs4524693	A	G	rs4524693	21871595	6.02E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
7	44354265	rs4298415	C	T	rs4298415	21871595	6.02E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
7	48360337	rs6949736	C	A	rs6949736	19508968	2.84E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ABCA13
7	77032997	rs1859572	C	T	rs1859572	22763110	1.74E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
7	78160248	rs6466265	A	G	rs6466265	22763110	3.72E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
7	94003260	rs6465411	T	C	rs6465411	21177295	1.78E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	94003260	rs6465411	T	C	rs6465411	21177295	6.49E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	94003260	rs6465411	T	C	rs6465411	21177295	7.37E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	95608753	rs1488517	T	C	rs1488517	22763110	3.56E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
7	98861307	rs6465748	T	C	rs6465748	19508968	1.85E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	99085879	rs2037595	A	G	rs2037595	19508968	1.30E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
7	106938420	rs3815148	A	C	rs3815148	20112360	8.00E-08	NA	1.14	[1.09-1.19]	1,341 European cases; 3,496 European controls	European(4837)	ALL(4837)	EUR(4837)	ALL(4837)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs3815148-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
7	106938420	rs3815148	A	C	rs3815148	21177295	7.00E-05	Knee osteoarthritis and/or hand osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	COG5
7	106938420	rs3815148	A	C	rs3815148	21177295	7.00E-05	Knee osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	COG5
7	106938420	rs3815148	A	C	rs3815148	21177295	8.00E-08	Knee osteoarthritis and/or hand osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	COG5
7	107207695	rs4730250	A	G	rs4730250	21068099	6.00E-08	NA	1.15	[1.10-1.22]	2,371 European ancestry cases; 35,909 European ancestry controls	European(38280)	ALL(38280)	EUR(38280)	ALL(38280)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs4730250-G	Meta-Analysis	Research Support, Non-U.S. Gov't	A
7	110133558	rs10270301	C	T	rs10270301	21177295	3.94E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	110157546	rs2966417	A	G	rs2966417	22763110	6.57E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
7	112159178	rs5009270	G	A	rs5009270	23989986	3.00E-06	NA	1.1	[1.06-1.14]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs5009270-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
7	116034844	rs11772856	C	T	rs11772856	19508968	1.60E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
7	137600690	rs273957	C	A,G,T	rs273957	21177295	1.55E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	CREB3L2
7	137600690	rs273957	C	A,G,T	rs273957	21177295	2.08E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	CREB3L2
8	4924197	rs7843140	A	C	rs7843140	21177295	1.26E-06	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
8	4924197	rs7843140	A	C	rs7843140	21177295	6.18E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
8	8109936	rs2945230	A	G	rs2945230	21177295	3.58E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	8109936	rs2945230	A	G	rs2945230	21177295	7.89E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	8109936	rs2945230	A	G	rs2945230	21177295	9.56E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	8601350	rs4841020	A	G	rs4841020	22763110	3.04E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
8	8681756	rs1876836	T	C	rs1876836	22763110	6.59E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
8	8747245	rs4841067	A	G	rs4841067	22763110	5.40E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
8	9246837	rs17662123	G	A	rs17662123	21177295	1.37E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9246837	rs17662123	G	A	rs17662123	21177295	3.11E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9246837	rs17662123	G	A	rs17662123	21177295	5.32E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9246837	rs17662123	G	A	rs17662123	21177295	6.68E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9395532	rs6601327	G	A	rs6601327	21177295	1.13E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9395532	rs6601327	G	A	rs6601327	21177295	7.56E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	9819890	rs609792	T	C	rs609792	22763110	4.61E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
8	10210451	rs6997710	A	G	rs6997710	22763110	6.92E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
8	15562672	rs1421259	A	G	rs1421259	22763110	5.74E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
8	25917711	rs4872393	G	A	rs4872393	21177295	1.90E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	25917711	rs4872393	G	A	rs4872393	21177295	7.18E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	25917711	rs4872393	G	A	rs4872393	21177295	8.18E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	32563924	rs2919381	A	G	rs2919381	21177295	7.56E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NRG1
8	32563924	rs2919381	A	G	rs2919381	21177295	8.81E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NRG1
8	58678194	rs13265778	C	T	rs13265778	19508968	5.76E-06	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
8	58694111	rs1561081	G	A	rs1561081	19508968	3.18E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
8	72649840	rs11989824	C	T	rs11989824	19508968	1.07E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
8	80562259	rs2979715	C	T	rs2979715	22763110	4.63E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
8	80597253	rs2467753	G	T	rs2467753	22763110	1.54E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
8	93298704	rs12544183	G	T	rs12544183	22566624	8.50E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	98288164	rs2289496	A	C	rs2289496	22763110	4.78E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
8	100432976	rs3103705	C	T	rs3103705	21177295	1.34E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	VPS13B
8	100432976	rs3103705	C	T	rs3103705	21177295	3.19E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	VPS13B
8	104122246	rs16870112	C	A,G,T	rs16870112	22763110	5.85E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
8	123448950	rs7813226	T	C	rs7813226	19508968	6.68E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
8	124086827	rs10956114	A	G	rs10956114	22763110	3.09E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
8	124665575	rs7463896	A	G	rs7463896	21177295	9.60E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
8	126516988	rs4512391	T	C	rs4512391	21177295	1.13E-06	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
8	126516988	rs4512391	T	C	rs4512391	21177295	1.80E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
8	133776163	rs2433051	T	C	rs2433051	21177295	1.18E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	133776163	rs2433051	T	C	rs2433051	21177295	4.83E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
8	142736531	rs4072286	T	G	rs4072286	22763110	3.92E-08	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
9	4657040	rs2146423	A	G	rs2146423	22763110	2.88E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
9	9119229	rs17589981	T	C	rs17589981	21177295	1.31E-06	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PTPRD
9	9119229	rs17589981	T	C	rs17589981	21177295	2.85E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PTPRD
9	9119229	rs17589981	T	C	rs17589981	21177295	5.19E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PTPRD
9	9970203	rs7860148	T	C	rs7860148	21177295	2.16E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	PTPRD
9	9970203	rs7860148	T	C	rs7860148	21177295	2.87E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	PTPRD
9	18927768	rs945442	C	A	rs945442	21177295	2.24E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
9	18927768	rs945442	C	A	rs945442	21177295	8.61E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
9	18927768	rs945442	C	A	rs945442	22763110	1.58E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
9	18930880	rs4977469	T	G	rs4977469	21177295	1.22E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	FAM154A
9	18930880	rs4977469	T	G	rs4977469	21177295	3.90E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	FAM154A
9	73736643	rs4620343	C	T	rs4620343	21177295	8.34E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
9	73736643	rs4620343	C	T	rs4620343	21177295	8.63E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
9	80137434	rs3780296	C	T	rs3780296	22763110	8.97E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
9	80918420	rs3758201	C	T	rs3758201	19508968	2.80E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PSAT1
9	82362167	rs10867419	C	T	rs10867419	19508968	2.33E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
9	82377443	rs1888073	T	G	rs1888073	19508968	1.21E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
9	90498210	rs4072357	T	C	rs4072357	22763110	2.90E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
9	96379797	rs12551314	C	A	rs12551314	23989986	4.30E-05	Male-specific	1.16	[1.07-1.25]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs12551314-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
9	110887048	rs1025571	C	A	rs1025571	21177295	1.49E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
9	110887048	rs1025571	C	A	rs1025571	21177295	8.73E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
9	115015710	rs10817301	G	A	rs10817301	21177295	3.83E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PTBP3
9	115015710	rs10817301	G	A	rs10817301	21177295	8.46E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PTBP3
9	116464160	rs2170226	C	T	rs2170226	19508968	2.65E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
9	119266695	rs4836732	C	T	rs4836732	22763110	2.48E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
9	119476270	rs719535	T	C	rs719535	22763110	9.02E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
9	119489376	rs10817928	C	T	rs10817928	21177295	3.23E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ASTN2
9	119489376	rs10817928	C	T	rs10817928	21177295	3.60E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ASTN2
9	119572876	rs1465918	G	T	rs1465918	19508968	3.16E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	ASTN2
9	122198457	rs11792112	T	C	rs11792112	21177295	4.50E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
9	122198457	rs11792112	T	C	rs11792112	21177295	5.79E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
9	122198457	rs11792112	T	C	rs11792112	21177295	7.56E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
9	132394270	rs2900277	G	T	rs2900277	22763110	8.44E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
9	135483721	rs445990	G	T	rs445990	19508968	9.93E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	DDX31
10	1509658	rs12782764	G	A	rs12782764	21177295	1.39E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ADARB2
10	1509658	rs12782764	G	A	rs12782764	21177295	5.23E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ADARB2
10	1509658	rs12782764	G	A	rs12782764	21177295	7.97E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ADARB2
10	3204561	rs7912487	C	T	rs7912487	19508968	3.20E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PITRM1
10	24294611	rs1970288	T	C	rs1970288	21177295	2.70E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	KIAA1217
10	24294611	rs1970288	T	C	rs1970288	21177295	4.39E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	KIAA1217
10	24294611	rs1970288	T	C	rs1970288	21177295	6.11E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	KIAA1217
10	33495983	rs2474714	A	G	rs2474714	22763110	7.56E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
10	49867327	rs1057549	G	A	rs1057549	21177295	1.29E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
10	49867327	rs1057549	G	A	rs1057549	21177295	7.83E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
10	56933921	rs9299558	C	A	rs9299558	22763110	9.92E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
10	80259796	rs7074960	G	A	rs7074960	21177295	1.82E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
10	80932607	rs10824726	T	G	rs10824726	21177295	8.16E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80932607	rs10824726	T	G	rs10824726	21177295	8.35E-06	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80944095	rs703979	T	C	rs703979	21177295	1.27E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80944095	rs703979	T	C	rs703979	21177295	1.68E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80944095	rs703979	T	C	rs703979	21177295	2.15E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80944095	rs703979	T	C	rs703979	21177295	3.92E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	81058027	rs1250552	A	G	rs1250552	22763110	3.13E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
10	95124673	rs787640	G	A	rs787640	22763110	9.23E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
10	97401996	rs11188412	G	A	rs11188412	22763110	3.24E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
10	121107900	rs11198893	G	A	rs11198893	21177295	9.00E-06	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	GRK5
10	121107900	rs11198893	G	A	rs11198893	21177295	9.27E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	GRK5
10	121107900	rs11198893	G	A	rs11198893	21177295	9.32E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	GRK5
10	130074063	rs7900125	G	A	rs7900125	21177295	5.48E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
10	130163817	rs7894663	A	G	rs7894663	21177295	3.55E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
10	130163817	rs7894663	A	G	rs7894663	21177295	7.51E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
11	8012077	rs7951923	A	C	rs7951923	21177295	1.05E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	EIF3F
11	8012077	rs7951923	A	C	rs7951923	21177295	4.84E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	EIF3F
11	8012077	rs7951923	A	C	rs7951923	21177295	5.89E-06	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	EIF3F
11	12415077	rs4757420	G	T	rs4757420	22763110	6.20E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
11	16963663	rs4756876	C	T	rs4756876	19508968	2.35E-06	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	PLEKHA7
11	26263085	rs9332433	T	C	rs9332433	21177295	2.47E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
11	26263085	rs9332433	T	C	rs9332433	21177295	4.94E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
11	27071118	rs7107938	C	T	rs7107938	19508968	2.02E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	BBOX1
11	60122857	rs4939346	G	A	rs4939346	19508968	2.05E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
11	62166235	rs7119797	C	T	rs7119797	22763110	5.06E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
11	62663659	rs547248	C	T	rs547248	21177295	3.70E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
11	82819298	rs17159801	G	A	rs17159801	22763110	2.34E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
11	90600576	rs2691829	T	C	rs2691829	22763110	9.38E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
11	94471927	rs1430860	G	A	rs1430860	19508968	5.64E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
11	102495998	rs2245803	T	G	rs2245803	21177295	5.24E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	MMP20
11	102495998	rs2245803	T	G	rs2245803	21177295	8.91E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	MMP20
11	109865559	rs7947141	C	T	rs7947141	19508968	3.04E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
11	114917927	rs4146886	A	G	rs4146886	19508968	1.98E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
11	120724018	rs6589848	T	C	rs6589848	22763110	9.36E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
11	124409935	rs948725	G	A	rs948725	19508968	1.17E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
11	124432323	rs2187149	A	G	rs2187149	19508968	2.57E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
11	124440617	rs12792184	C	T	rs12792184	19508968	5.94E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	OR8A1
11	126370843	rs7941193	G	A	rs7941193	22763110	3.26E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
11	131613622	rs2063024	G	A	rs2063024	21177295	2.26E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NTM
11	131613622	rs2063024	G	A	rs2063024	21177295	6.56E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NTM
11	132420784	rs7947822	C	A	rs7947822	21177295	1.04E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	OPCML
11	132420784	rs7947822	C	A	rs7947822	21177295	1.10E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	OPCML
11	132755278	rs2063071	G	A	rs2063071	19508968	2.30E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G,A	OPCML
11	133168523	rs7122854	A	G	rs7122854	22763110	8.08E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
12	18102310	rs7970960	T	C	rs7970960	19508968	2.59E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
12	24969627	rs7305794	T	C	rs7305794	22763110	8.26E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
12	28014970	rs10492367	G	T	rs10492367	22763110	7.00E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
12	28643213	rs6487684	T	C	rs6487684	22763110	7.35E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
12	31377942	rs4931462	T	G	rs4931462	22566624	4.30E-07	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
12	45025396	rs7305652	C	T	rs7305652	19508968	3.66E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NELL2
12	45158289	rs10506257	C	T	rs10506257	19508968	3.07E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NELL2
12	47935320	rs7971524	T	C	rs7971524	21177295	3.01E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
12	47935320	rs7971524	T	C	rs7971524	21177295	3.72E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
12	48389643	rs1034762	A	C	rs1034762	22763110	4.36E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
12	67958700	rs10878630	G	A	rs10878630	23989986	1.10E-05	Female-specific	1.09	[1.04-1.14]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs10878630-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
12	76604910	rs7311560	C	T	rs7311560	19508968	2.00E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
12	78432055	rs11107957	A	C	rs11107957	22763110	7.19E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
12	85364479	rs1404866	G	T	rs1404866	22763110	3.04E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
12	94246356	rs11107219	A	G	rs11107219	22763110	9.81E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
12	95160155	rs2008023	A	G	rs2008023	21177295	1.13E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
12	95160155	rs2008023	A	G	rs2008023	21177295	1.24E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
12	95160155	rs2008023	A	G	rs2008023	21177295	4.49E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
12	95160155	rs2008023	A	G	rs2008023	21177295	5.48E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
12	105060767	rs835487	A	G	rs835487	22763110	3.26E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
12	108618630	rs3764002	C	T	rs3764002	21177295	6.34E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	WSCD2
12	108618630	rs3764002	C	T	rs3764002	21177295	8.80E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	WSCD2
12	119673183	rs11064722	C	T	rs11064722	22763110	6.16E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
12	124375210	rs10773046	A	G	rs10773046	23989986	2.00E-06	NA	1.07	[1.03-1.11]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs10773046-G	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
12	128792381	rs4882730	C	A	rs4882730	19508968	1.73E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	TMEM132C
13	25876011	rs11556093	G	A	rs12871898	19508968	9.01E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	NA	NUPL1
13	32062345	rs17076208	G	T	rs17076208	21177295	5.94E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
13	32062345	rs17076208	G	T	rs17076208	21177295	6.50E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
13	68174418	rs4544137	T	C	rs4544137	22763110	2.44E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
13	68365830	rs7994526	A	G	rs7994526	22763110	1.74E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G,A
13	76747030	rs2036717	T	C	rs2036717	22763110	7.04E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
13	76840783	rs885421	C	T	rs885421	21177295	2.86E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
13	76840783	rs885421	C	T	rs885421	21177295	3.23E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
13	85881124	rs1873288	G	A	rs1873288	19508968	1.99E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
13	107057420	rs9520058	T	G	rs9520058	22763110	1.01E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
13	113694509	rs11842874	A	G	rs11842874	21871595	2.00E-08	NA	1.17	[1.11-1.23]	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs11842874-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
13	113695229	rs1888227	T	C	rs1888227	21871595	6.75E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
14	35246472	rs8015303	A	G	rs8015303	22763110	8.89E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
14	43171328	rs1627411	T	C	rs1627411	22763110	8.83E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
14	50418230	rs7155791	C	T	rs7155791	22763110	9.52E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
14	52583459	rs1998094	C	T	rs1998094	22763110	7.91E-07	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
14	54228517	rs1958654	T	C	rs1958654	19508968	2.46E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T,C	NA
14	71309483	rs979536	A	G	rs979536	19508968	3.77E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
14	71314581	rs1990037	C	A	rs1990037	19508968	4.95E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
14	71737314	rs11623996	A	G	rs11623996	19508968	5.55E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	C14orf56
14	71851912	rs41216	C	T	rs41216	19508968	1.47E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
14	78652519	rs10144429	G	A	rs10144429	22763110	8.48E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
14	96323265	rs12891775	A	G	rs12891775	21871595	2.33E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
14	96328262	rs61983843	A	C	rs61983843	21871595	2.28E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
14	96334783	rs35074918	A	C	rs35074918	21871595	2.18E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
14	96338601	rs61984878	T	A	rs61984878	21871595	2.15E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
14	96354124	rs34767699	G	A	rs34767699	21871595	4.82E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
14	96356164	rs12888779	G	A	rs12888779	21871595	5.46E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
14	104029819	rs2296482	T	G	rs2296482	21177295	3.31E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	APOPT1
14	104029819	rs2296482	T	G	rs2296482	21177295	3.83E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	APOPT1
14	104029819	rs2296482	T	G	rs2296482	21177295	3.94E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	APOPT1
15	26232919	rs938076	G	A	rs938076	19508968	3.72E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LOC100128714
15	33087472	rs11634255	G	A	rs11634255	22763110	1.34E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
15	33785483	rs1369308	C	T	rs1369308	21177295	1.58E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	RYR3
15	33785483	rs1369308	C	T	rs1369308	21177295	6.20E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	RYR3
15	34075300	rs12901404	T	C	rs12901404	19508968	7.78E-07	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	RYR3
15	34089496	rs12900756	A	G	rs12900756	19508968	3.62E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	RYR3
15	35148102	rs1055356	T	C	rs1055356	19508968	3.30E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
15	35152649	rs3858931	T	C	rs3858931	19508968	3.31E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T,C	AQR
15	35196878	rs717941	A	C	rs717941	19508968	1.63E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	AQR
15	35217536	rs7169701	T	C	rs7169701	19508968	2.47E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	AQR
15	58246802	rs3204689	G	C	rs3204689	24728293	1.00E-11	(Severe thumbs and severe fingers)	1.46	[1.31-1.63]	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs3204689-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
15	58246802	rs3204689	G	C	rs3204689	24728293	5.10E-17	(Severe thumbs)	1.18	NA	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs3204689-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
15	58246802	rs3204689	G	C	rs3204689	24728293	5.60E-12	(Severe fingers)	1.26	NA	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs3204689-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
15	58256127	rs4646626	C	T	rs4646626	22763110	8.86E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
15	58336000	rs4238326	T	C	rs4238326	24728293	1.50E-08	(Severe thumbs)	1.21	NA	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs4238326-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
15	58336000	rs4238326	T	C	rs4238326	24728293	2.00E-11	(Severe fingers)	1.25	NA	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs4238326-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
15	58336000	rs4238326	T	C	rs4238326	24728293	8.60E-11	(Severe thumbs and severe fingers)	1.44	NA	623 European ancestry cases; 69,153 European ancestry controls	European(69776)	ALL(69776)	EUR(69776)	ALL(69776)	Osteoarthritis (hand, severe)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs4238326-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
15	63792486	rs17184382	A	C	rs17184382	21177295	1.20E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
15	63792486	rs17184382	A	C	rs17184382	21177295	1.31E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
15	63792486	rs17184382	A	C	rs17184382	21177295	2.10E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
15	63804555	rs12915297	T	C	rs12915297	21871595	5.23E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
15	63871292	rs7178762	C	T	rs7178762	21177295	2.12E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	USP3
15	63871292	rs7178762	C	T	rs7178762	21177295	2.28E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	USP3
15	63871292	rs7178762	C	T	rs7178762	21177295	6.98E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	USP3
15	64150869	rs7180823	T	G	rs7180823	21177295	1.51E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
15	64150869	rs7180823	T	G	rs7180823	21177295	3.72E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
15	64150869	rs7180823	T	G	rs7180823	21177295	9.32E-06	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
15	64167098	rs33942564	G	GA,GT,GTA	rs34675318	21871595	5.56E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
15	64167098	rs34675318	G	A	rs34675318	21871595	5.56E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
15	67326140	rs266339	T	C	rs266339	21177295	1.26E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
15	67326140	rs266339	T	C	rs266339	21177295	8.66E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
15	70156785	rs12907468	T	A	rs12907468	22566624	7.80E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
15	89417629	rs2280465	G	A	rs2280465	21177295	4.43E-06	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ACAN
15	89417629	rs2280465	G	A	rs2280465	21177295	4.94E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ACAN
15	91340995	rs2380165	A	G	rs2380165	22566624	5.60E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	BLM
15	93602056	rs8032755	G	A	rs8032755	22763110	7.40E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
16	5031844	rs2908646	A	G	rs2908646	22763110	9.17E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
16	6336912	rs716508	C	T	rs716508	19508968	6.40E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	RBFOX1
16	6345924	rs4786850	C	A	rs4786850	19508968	8.39E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	RBFOX1
16	9417288	rs12596722	A	C	rs12596722	22763110	1.23E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
16	9787937	rs12923310	G	T	rs12923310	22763110	7.45E-08	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
16	14013898	rs112732710	T	C	rs112732710	21871595	8.74E-06	NA	NA	NA	3,177 European ancestry cases; 4,894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
16	53839135	rs8044769	T	C	rs8044769	22763110	4.00E-06	NA	1.07	[1.04-1.10]	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs8044769-C	Multicenter Study	Research Support, Non-U.S. Gov't	C
16	56330832	rs9937815	A	G	rs9937815	22763110	8.75E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
16	66412729	rs7404629	G	A	rs7404629	22763110	7.23E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
16	78151746	rs16947129	T	C	rs16947129	22763110	2.39E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
17	4539392	rs7217186	C	T	rs7217186	19508968	1.41E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ALOX15
17	16978834	rs4078062	G	A	rs4078062	22763110	9.41E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
17	18139896	rs2746028	G	T	rs2746028	21177295	1.14E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LLGL1
17	18139896	rs2746028	G	T	rs2746028	21177295	1.59E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LLGL1
17	18139896	rs2746028	G	T	rs2746028	21177295	7.07E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	LLGL1
17	45808828	rs4794067	T	C	rs4794067	19508968	2.22E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	TBX21
17	59667953	rs17610181	G	A	rs17610181	23989986	8.00E-06	NA	1.12	[1.06-1.18]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs17610181-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
17	64708866	rs8081512	A	G	rs8081512	19508968	3.07E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	PRKCA
17	69786943	rs8080960	G	A	rs8080960	22763110	5.75E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
17	75706339	rs1529964	T	C	rs1529964	19508968	2.01E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
18	10478812	rs11665347	G	A	rs11665347	21177295	5.73E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	APCDD1
18	10478812	rs11665347	G	A	rs11665347	22763110	7.97E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
18	53633786	rs1985049	T	C	rs1985049	19508968	2.05E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
18	59494069	rs8091174	C	T	rs8091174	21177295	1.00E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	RNF152
18	59494069	rs8091174	C	T	rs8091174	21177295	2.04E-05	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	RNF152
18	59494069	rs8091174	C	T	rs8091174	21177295	9.69E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	RNF152
18	64148687	rs12454396	C	T	rs12454396	22763110	7.47E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
18	65318652	rs2440515	G	A	rs2440515	21177295	1.67E-04	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	LOC643542
18	65318652	rs2440515	G	A	rs2440515	21177295	2.03E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	LOC643542
18	72218701	rs17089382	C	T	rs17089382	22763110	3.28E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
18	75475146	rs2654179	C	T	rs2654179	19508968	2.89E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
18	75499666	rs1032914	C	T	rs1032914	19508968	3.36E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
18	75512158	rs4890850	C	T	rs4890850	19508968	2.21E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
18	75547049	rs7241566	T	C	rs7241566	19508968	3.90E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
18	77356003	rs660749	T	C	rs660749	19508968	3.45E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
19	2177193	rs12982744	C	G	rs12982744	22566624	1.00E-11	NA	0.09	[NA] mm increase	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	rs12982744-G	Research Support, Non-U.S. Gov't	C	DOT1L
19	2183175	rs2864419	G	T	rs2864419	21177295	4.89E-05	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	DOT1L
19	2183175	rs2864419	G	T	rs2864419	21177295	6.62E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	T	DOT1L
19	2184005	rs12974139	T	C	rs12974139	22763110	1.69E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
19	4554774	rs1610093	T	C	rs1610093	22763110	2.13E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
19	8111982	rs10426443	G	A	rs10426443	22763110	8.37E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
19	17580707	rs11665774	A	G	rs11665774	22566624	4.00E-06	NA	NA	NA	6,523 individuals	NOPOP(6523)	ALL(6523)	NOPOP(6523)	ALL(6523)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
19	18567039	rs731945	C	T	rs731945	19508968	7.72E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ELL
19	29755681	rs879122	C	T	rs879122	19508968	1.24E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	G	NA
19	34019755	rs4805902	C	T	rs4805902	21177295	4.50E-04	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
19	34019755	rs4805902	C	T	rs4805902	21177295	5.06E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
19	49092234	rs10426377	C	A	rs10426377	22763110	7.29E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
19	49206603	rs281377	C	T	rs281377	19508968	9.55E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	FUT2
20	13233011	rs6109781	A	C	rs6109781	19508968	3.60E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	ISM1
20	22939045	rs869611	G	A	rs869611	21177295	6.42E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA
20	22961890	rs1360400	G	A	rs1360400	22763110	7.22E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
20	34025983	rs143383	A	G	rs143383	21177295	2.00E-13	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	GDF5
20	34025983	rs143383	A	G	rs143383	21177295	9.00E-05	Knee osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	C	GDF5
20	41109702	rs172981	T	C	rs172981	22763110	1.45E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	T
20	46095649	rs6094710	G	A	rs6094710	23989986	2.00E-10	NA	1.28	[1.18-1.39]	up to 4,734 European ancestry cases; up to 46,903 European ancestry controls	European(51637)	ALL(51637)	EUR(51637)	ALL(51637)	Osteoarthritis (hip)	HPOID:0008843	Hip osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	rs6094710-A	Review	Meta-Analysis	Research Support, Non-U.S. Gov't
20	48433059	rs17785895	A	G	rs17785895	22763110	9.41E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
20	55116737	rs6092326	C	T	rs6092326	19508968	2.77E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	C	NA
20	55132478	rs4811713	T	C	rs4811713	19508968	1.95E-05	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
20	60867591	rs4925370	A	G	rs4925370	22763110	8.11E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
21	33441610	rs7277441	C	T	rs7277441	19508968	3.63E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	T	NA
21	40757973	rs2244352	T	G	rs2244352	21177295	3.20E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	WRB
21	40757973	rs2244352	T	G	rs2244352	21177295	6.94E-04	Osteoarthritis (females)	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	WRB
21	40757973	rs2244352	T	G	rs2244352	21177295	8.10E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G	WRB
22	18299197	rs2277831	A	G	rs2277831	21177295	2.28E-05	Osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G,A	MICAL3
22	18299197	rs2277831	A	G	rs2277831	21177295	8.44E-04	Hip osteoarthritis	NA	NA	3177 European ancestry cases; 4894 European ancestry controls	European(8071)	ALL(8071)	EUR(8071)	ALL(8071)	Osteoarthritis (knee and hip)	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	NA	NA	NA	NA	Arthritis	NA	Research Support, Non-U.S. Gov't	G,A	MICAL3
22	21352120	rs3747081	G	A	rs3747081	22763110	6.81E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	G
22	23929852	rs7287616	C	T	rs7287616	22763110	7.52E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	C
22	28159672	rs5762347	G	A	rs5762347	22763110	5.98E-06	NA	NA	NA	7,410 European ancestry cases; 11,009 European ancestry controls	European(18419)	ALL(18419)	EUR(18419)	ALL(18419)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Multicenter Study	Research Support, Non-U.S. Gov't	A
22	47710815	rs5767675	G	A	rs5767675	19508968	2.08E-04	NA	NA	NA	1,804 European ancestry individuals	European(1804)	ALL(1804)	EUR(1804)	ALL(1804)	Osteoarthritis	HPOID:0002758	Osteoarthritis	DOID:8398	osteoarthritis	D010003	Osteoarthritis	EFOID:0002506	osteoarthritis	Arthritis	NA	Research Support, Non-U.S. Gov't	A	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:17)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0029408	acetaminophen	D000082	103-90-2	osteoarthritis	MESH:D010003	therapeutic	18177922
C0029408	aspartame	D001218	22839-47-0	osteoarthritis	MESH:D010003	therapeutic	9630831
C0029408	capsaicin	D002211	404-86-4	osteoarthritis	MESH:D010003	therapeutic	20538089
C0029408	celecoxib	D000068579	-	osteoarthritis	MESH:D010003	therapeutic	11793622
C0029408	diclofenac	D004008	15307-86-5	osteoarthritis	MESH:D010003	therapeutic	12051399
C0029408	doxycycline	D004318	564-25-0	osteoarthritis	MESH:D010003	therapeutic	17267227
C0029408	fenoprofen	D005279	31879-05-7	osteoarthritis	MESH:D010003	therapeutic	6803950
C0029408	indomethacin	D007213	53-86-1	osteoarthritis	MESH:D010003	therapeutic	1096903
C0029408	meloxicam	C065757	71125-38-7	osteoarthritis	MESH:D010003	therapeutic	11322690
C0029408	nicotine	D009538	-	osteoarthritis	MESH:D010003	marker/mechanism	26776438
C0029408	piroxicam	D010894	36322-90-4	osteoarthritis	MESH:D010003	therapeutic	2004031
C0029408	rofecoxib	C116926	-	osteoarthritis	MESH:D010003	therapeutic	12175641
C0029408	sulindac	D013467	38194-50-2	osteoarthritis	MESH:D010003	therapeutic	3623432
C0029408	tenoxicam	C032801	59804-37-4	osteoarthritis	MESH:D010003	therapeutic	1778090
C0029408	tolmetin	D014046	26171-23-3	osteoarthritis	MESH:D010003	therapeutic	8452658
C0029408	tramadol	D014147	27203-92-5	osteoarthritis	MESH:D010003	therapeutic	11240075
C0029408	valdecoxib	C406224	-	osteoarthritis	MESH:D010003	therapeutic	15266215

FDA approved drug and dosage information(Total Drugs:11)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D010003	vioxx	rofecoxib	12.5MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D010003	vioxx	rofecoxib	12.5MG/5ML	SUSPENSION;ORAL	Discontinued	None	No	No
MESH:D010003	vioxx	rofecoxib	12.5MG	TABLET; ORAL	Discontinued	None	No	No
MESH:D010003	mobic	meloxicam	7.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D010003	mobic	meloxicam	7.5MG/5ML	SUSPENSION;ORAL	Prescription	None	Yes	Yes
MESH:D010003	celebrex	celecoxib	100MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D010003	celebrex	celecoxib	100MG	CAPSULE;ORAL	Prescription	None	No	No
MESH:D010003	ofirmev	acetaminophen	1GM/100ML (10MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	Yes
MESH:D010003	ofirmev	acetaminophen	1GM/100ML (10MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	Yes
MESH:D010003	acetaminophen	acetaminophen	650MG	SUPPOSITORY;RECTAL	Over-the-counter	None	Yes	Yes
MESH:D010003	acetaminophen	acetaminophen	650MG	SUPPOSITORY;RECTAL	Over-the-counter	None	Yes	Yes

FDA labeling changes(Total Drugs:11)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D010003	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D010003	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D010003	08/19/2004	vioxx	rofecoxib	Pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) due to safety concerns on September 30, 2004.	Labeling	B	-	-	-	Merck	02/18/2004	FALSE'
MESH:D010003	11/8/2005	mobic	meloxicam	Relief of signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Safety and efficacy established in patients 2 years of age and older Clinical studies evaluated doses ranging from 0.125 mg/kg/day to 0.375 mg/kg/day. There was no additional benefit demonstrated by doses above 0.125 mg/kg/day in the clinical trials. The lowest effective dose should be used Adverse events in children were similar to those in adults including skin reactions and gastrointestinal bleed risk Information on dose, PK parameters, AE profile and clinical studies	Labeling	-	-	B, P	-	Boehringer Ingelheim	04/15/2005	FALSE'
MESH:D010003	11/8/2005	mobic	meloxicam	Relief of signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis	Safety and efficacy established in patients 2 years of age and older Clinical studies evaluated doses ranging from 0.125 mg/kg/day to 0.375 mg/kg/day. There was no additional benefit demonstrated by doses above 0.125 mg/kg/day in the clinical trials. The lowest effective dose should be used Adverse events in children were similar to those in adults including skin reactions and gastrointestinal bleed risk Information on dose, PK parameters, AE profile and clinical studies	Labeling	-	-	B, P	-	Boehringer Ingelheim	04/15/2005	FALSE'
MESH:D010003	12/15/2006	celebrex	celecoxib	Relief of the signs and symptoms of juvenile rheumatoid arthritis (JRA)	New indication in 2 years and older Has not been studied in patients < 2 years, in patients with body weight < 10 kg, or in patients with active systemic features Celecoxib should be used only with caution in patients with systemic onset JRA due to the risk for serious adverse reactions including the risk of disseminated intravascular coagulation The long-term cardiovascular toxicity in children has not been evaluated; it is unknown if the long-term risk may be similar to that seen in adults New 50 mg capsule developed Information on adding contents of a capsule to applesauce. for patients with difficulty swallowing capsules Information on dose, clinical studies, PK parameters, AEs	Labeling	B	-	-	-	Pfizer	08/23/2006	FALSE'
MESH:D010003	12/15/2006	celebrex	celecoxib	Relief of the signs and symptoms of juvenile rheumatoid arthritis (JRA)	New indication in 2 years and older Has not been studied in patients < 2 years, in patients with body weight < 10 kg, or in patients with active systemic features Celecoxib should be used only with caution in patients with systemic onset JRA due to the risk for serious adverse reactions including the risk of disseminated intravascular coagulation The long-term cardiovascular toxicity in children has not been evaluated; it is unknown if the long-term risk may be similar to that seen in adults New 50 mg capsule developed Information on adding contents of a capsule to applesauce. for patients with difficulty swallowing capsules Information on dose, clinical studies, PK parameters, AEs	Labeling	B	-	-	-	Pfizer	08/23/2006	FALSE'
MESH:D010003	2/11/2010	ofirmev	acetaminophen	Management of mild-to-moderate pain, for the management of moderate-to-severe pain with adjunctive opioid analgesics, and for the reduction of fever	The safety and effectiveness of Ofirmev for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of Ofirmev in adults. Additional safety and PK data was collected in 355 from premature neonates to adolescents. The effectiveness of Ofirmev for the treatment of acute pain and fever has not been studied in pediatric patients < 2 years of age.The PK exposure of Ofirmev observed in children and adolescents is similar to adults, but higher in neonates and infants. Dosing simulations from PK data in infants and neonates suggest that dose reductions of 33% in infants 1 month to < 2 years of age, and 50% in neonates up to 28 days, with a minimum dosing interval of 6 hours, will produce a PK exposure similar to that observed in children age 2 years and olderMost common adverse reactions in pediatric patients were nausea, vomiting, constipation, pruritus, agitation, and atelectasis.Information on dosing, clinical studies, adverse reactions and PK parametersNew dosage form and route of administration	Labeling	-	P	-	-	Cadence	-	FALSE'
MESH:D010003	01/27/2017	ofirmev	acetaminophen	Treatmeny of pain and fever in pediatric patients birth to 2 years	Treatment of pain Efficacy was not demonstrated in pediatric patients younger than 2 years in a double-blind, placebo-controlled study of 198 pediatric patients younger than 2 years. Pediatric patients less than 2 years of age, including neonates from 28 to 40 weeks gestational age at birth, were randomized to receive opioid plus acetaminophen or opioid plus placebo. No difference in analgesic effect of intravenous acetaminophen, measured by assessment of reduced need for additional opioid treatment for pain control, was observed. Treatment of fever The safety and effectiveness for the treatment of fever in pediatric patients, including premature neonates born at 32 weeks or greater gestation is supported by adequate and well-controlled studies of Ofirmev in adults, clinical studies in 244 pediatric patients 2 years and older, and safety and pharmacokinetic data from 239 patients younger than 2 years including neonates 32 weeks or greater gestational age. Information on dosing, clinical trials. Postmarketing study.	Labeling	-	-	B,P	-	Mallinckrodt	11/7/2016	FALSE
MESH:D010003	2/11/2010	ofirmev	acetaminophen	Management of mild-to-moderate pain, for the management of moderate-to-severe pain with adjunctive opioid analgesics, and for the reduction of fever	The safety and effectiveness of Ofirmev for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of Ofirmev in adults. Additional safety and PK data was collected in 355 from premature neonates to adolescents. The effectiveness of Ofirmev for the treatment of acute pain and fever has not been studied in pediatric patients < 2 years of age.The PK exposure of Ofirmev observed in children and adolescents is similar to adults, but higher in neonates and infants. Dosing simulations from PK data in infants and neonates suggest that dose reductions of 33% in infants 1 month to < 2 years of age, and 50% in neonates up to 28 days, with a minimum dosing interval of 6 hours, will produce a PK exposure similar to that observed in children age 2 years and olderMost common adverse reactions in pediatric patients were nausea, vomiting, constipation, pruritus, agitation, and atelectasis.Information on dosing, clinical studies, adverse reactions and PK parametersNew dosage form and route of administration	Labeling	-	P	-	-	Cadence	-	FALSE'
MESH:D010003	01/27/2017	ofirmev	acetaminophen	Treatmeny of pain and fever in pediatric patients birth to 2 years	Treatment of pain Efficacy was not demonstrated in pediatric patients younger than 2 years in a double-blind, placebo-controlled study of 198 pediatric patients younger than 2 years. Pediatric patients less than 2 years of age, including neonates from 28 to 40 weeks gestational age at birth, were randomized to receive opioid plus acetaminophen or opioid plus placebo. No difference in analgesic effect of intravenous acetaminophen, measured by assessment of reduced need for additional opioid treatment for pain control, was observed. Treatment of fever The safety and effectiveness for the treatment of fever in pediatric patients, including premature neonates born at 32 weeks or greater gestation is supported by adequate and well-controlled studies of Ofirmev in adults, clinical studies in 244 pediatric patients 2 years and older, and safety and pharmacokinetic data from 239 patients younger than 2 years including neonates 32 weeks or greater gestational age. Information on dosing, clinical trials. Postmarketing study.	Labeling	-	-	B,P	-	Mallinckrodt	11/7/2016	FALSE