PedAM

Pediatric Disease Annotations & Medicines


	orthostatic intolerance

Disease ID	585
Disease	orthostatic intolerance
Definition	Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)
Synonym	intolerance, orthostatic orthostatic intolerance [disease/finding]
OMIM	OMIM:604715
DOID	DOID:0050533
UMLS	C1535893
MeSH	D054971
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:5) C0015674 \| chronic fatigue syndrome \| 4 C0149931 \| migraine \| 1 C0014070 \| encephalomyelitis \| 1 C0015674 \| myalgic encephalomyelitis \| 1 C0034372 \| tetraplegia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) SLC6A2 \| 6530 \| CTD_human;UNIPROT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 6530 \| SLC6A2 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	585
Disease	orthostatic intolerance
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0012378 \| Fatigue \| 6 HP:0012432 \| Chronic fatigue \| 4 HP:0001279 \| Syncope \| 3 HP:0002459 \| Dysautonomia \| 2 HP:0012668 \| Situational syncope \| 2 HP:0002615 \| Low blood pressure \| 1 HP:0012417 \| Hypocapnia \| 1 HP:0001649 \| Tachycardia \| 1 HP:0011106 \| Depleted blood volume \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0001278 \| Orthostatic hypotension \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0002018 \| Nausea \| 1 HP:0012531 \| Pain \| 1

Disease ID	585
Disease	orthostatic intolerance
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2712322 \| tachycardia C1695782 \| cerebral hypoperfusion C1145628 \| disorders of the autonomic nervous system C0426768 \| o sign C0426576 \| gastrointestinal symptoms C0039070 \| syncope C0036161 \| o variant C0013363 \| dysautonomia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0039070 \| syncope \| 3 C0039231 \| tachycardia \| 1 C0426768 \| o sign \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1535893	nortriptyline	D009661	72-69-5	orthostatic intolerance	MESH:D054971	marker/mechanism	3756264

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics