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PedAM

Pediatric Disease Annotations & Medicines



   oral submucous fibrosis
  

Disease ID 70
Disease oral submucous fibrosis
Definition
Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
Synonym
fibroses, oral submucous
fibrosis, oral submucous
oral submucosal fibrosis (disorder)
oral submucous fibroses
oral submucous fibrosis [disease/finding]
submucous fibroses, oral
submucous fibrosis, oral
Orphanet
DOID
ICD10
UMLS
C0029172
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:3)
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:15)
TNF  |  7124  |  CTD_human
TGFB1  |  7040  |  CTD_human
CTLA4  |  1493  |  CTD_human
IFNG  |  3458  |  CTD_human
COL1A2  |  1278  |  CTD_human
COL1A1  |  1277  |  CTD_human
MMP1  |  4312  |  CTD_human
MMP9  |  4318  |  CTD_human
PTGS2  |  5743  |  CTD_human
CST3  |  1471  |  CTD_human
MMP2  |  4313  |  CTD_human
TIMP1  |  7076  |  CTD_human
LOX  |  4015  |  CTD_human
FGF2  |  2247  |  CTD_human
MICA  |  100507436  |  CTD_human
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:15)
1277  |  COL1A1  |  infer
1278  |  COL1A2  |  infer
1471  |  CST3  |  infer
1493  |  CTLA4  |  infer
3105  |  HLA-A  |  infer
3106  |  HLA-B  |  infer
3107  |  HLA-C  |  infer
3119  |  HLA-DQB1  |  infer
3123  |  HLA-DRB1  |  infer
4015  |  LOX  |  infer
4049  |  LTA  |  infer
100507436  |  MICA  |  infer
4317  |  MMP8  |  infer
7040  |  TGFB1  |  infer
7124  |  TNF  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:101)
3053  |  SERPIND1  |  DISEASES
3162  |  HMOX1  |  DISEASES
8106  |  PABPN1  |  DISEASES
7076  |  TIMP1  |  DISEASES
4313  |  MMP2  |  DISEASES
6422  |  SFRP1  |  DISEASES
7040  |  TGFB1  |  DISEASES
973  |  CD79A  |  DISEASES
1311  |  COMP  |  DISEASES
1577  |  CYP3A5  |  DISEASES
5054  |  SERPINE1  |  DISEASES
1277  |  COL1A1  |  DISEASES
595  |  CCND1  |  DISEASES
2729  |  GCLC  |  DISEASES
4015  |  LOX  |  DISEASES
9499  |  MYOT  |  DISEASES
1958  |  EGR1  |  DISEASES
847  |  CAT  |  DISEASES
2952  |  GSTT1  |  DISEASES
3852  |  KRT5  |  DISEASES
1571  |  CYP2E1  |  DISEASES
891  |  CCNB1  |  DISEASES
3569  |  IL6  |  DISEASES
7057  |  THBS1  |  DISEASES
999  |  CDH1  |  DISEASES
7077  |  TIMP2  |  DISEASES
2247  |  FGF2  |  DISEASES
7067  |  THRA  |  DISEASES
4258  |  MGST2  |  DISEASES
8034  |  SLC25A16  |  DISEASES
3373  |  HYAL1  |  DISEASES
6425  |  SFRP5  |  DISEASES
2252  |  FGF7  |  DISEASES
1000  |  CDH2  |  DISEASES
7157  |  TP53  |  DISEASES
6317  |  SERPINB3  |  DISEASES
1562  |  CYP2C18  |  DISEASES
10  |  NAT2  |  DISEASES
11197  |  WIF1  |  DISEASES
3856  |  KRT8  |  DISEASES
152185  |  SPICE1  |  DISEASES
1278  |  COL1A2  |  DISEASES
4314  |  MMP3  |  DISEASES
4071  |  TM4SF1  |  DISEASES
1281  |  COL3A1  |  DISEASES
8625  |  RFXANK  |  DISEASES
7015  |  TERT  |  DISEASES
2944  |  GSTM1  |  DISEASES
27122  |  DKK3  |  DISEASES
2149  |  F2R  |  DISEASES
4312  |  MMP1  |  DISEASES
255324  |  EPGN  |  DISEASES
4088  |  SMAD3  |  DISEASES
1572  |  CYP2F1  |  DISEASES
55256  |  ADI1  |  DISEASES
1429  |  CRYZ  |  DISEASES
10249  |  GLYAT  |  DISEASES
57402  |  S100A14  |  DISEASES
7366  |  UGT2B15  |  DISEASES
1499  |  CTNNB1  |  DISEASES
6483  |  ST3GAL2  |  DISEASES
2224  |  FDPS  |  DISEASES
54097  |  FAM3B  |  DISEASES
871  |  SERPINH1  |  DISEASES
3123  |  HLA-DRB1  |  DISEASES
5599  |  MAPK8  |  DISEASES
6935  |  ZEB1  |  DISEASES
4283  |  CXCL9  |  DISEASES
3880  |  KRT19  |  DISEASES
7052  |  TGM2  |  DISEASES
7042  |  TGFB2  |  DISEASES
5743  |  PTGS2  |  DISEASES
1660  |  DHX9  |  DISEASES
1490  |  CTGF  |  DISEASES
135112  |  NCOA7  |  DISEASES
4014  |  LOR  |  DISEASES
11218  |  DDX20  |  DISEASES
2316  |  FLNA  |  DISEASES
3725  |  JUN  |  DISEASES
4318  |  MMP9  |  DISEASES
2022  |  ENG  |  DISEASES
56288  |  PARD3  |  DISEASES
7046  |  TGFBR1  |  DISEASES
84930  |  MASTL  |  DISEASES
1471  |  CST3  |  DISEASES
2512  |  FTL  |  DISEASES
1543  |  CYP1A1  |  DISEASES
7158  |  TP53BP1  |  DISEASES
3875  |  KRT18  |  DISEASES
7247  |  TSN  |  DISEASES
307  |  ANXA4  |  DISEASES
91807  |  MYLK3  |  DISEASES
1286  |  COL4A4  |  DISEASES
23028  |  KDM1A  |  DISEASES
1029  |  CDKN2A  |  DISEASES
7124  |  TNF  |  DISEASES
7465  |  WEE1  |  DISEASES
2263  |  FGFR2  |  DISEASES
6424  |  SFRP4  |  DISEASES
5478  |  PPIA  |  DISEASES
8754  |  ADAM9  |  DISEASES
Locus(Waiting for update.)
Disease ID 70
Disease oral submucous fibrosis
Integrated Phenotype
HPO | Name(Total Integrated Phenotypes:7)
HP:0000600  |  Abnormality of the pharynx
HP:0000163  |  Abnormality of the oral cavity
HP:0012182  |  Oropharyngeal squamous cell carcinoma
HP:0001371  |  Flexion contracture
HP:0000160  |  Narrow mouth
HP:0000211  |  Trismus
HP:0100825  |  Cheilitis
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:4)
HP:0030731  |  Carcinoma  |  2
HP:0002860  |  Squamous cell carcinoma  |  1
HP:0003712  |  Hypertrophic muscles  |  1
HP:0000211  |  Trismus  |  1
Disease ID 70
Disease oral submucous fibrosis
Manually Symptom
UMLS  | Name(Total Manually Symptoms:5)
C1608408  |  malignant transformation
C1527383  |  morphoea
C0234958  |  muscle degeneration
C0031256  |  petechiae
C0007137  |  squamous cell carcinoma
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:1)
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:1)
HP ID HP Name MP ID MP Name Annotation
HP:0000163Abnormality of the oral cavityMP:0006271abnormal involution of the mammary gland;HP:0000600Abnormality of the pharynx
Mapped by homologous gene(Total Items:1)
HP ID HP Name MP ID MP Name Annotation
HP:0000163Abnormality of the oral cavityMP:0010211abnormal acute phase protein level;HP:0001371Flexion contracture
Chemical(Total Drugs:0)
(Waiting for update.)
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)