PedAM
Pediatric Disease Annotations & Medicines
| oral lichen planus | ||||
| Disease ID | 798 |
|---|---|
| Disease | oral lichen planus |
| Definition | Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry) |
| Synonym | lichen oral planus lichen planus oral lichen planus, oral lichen planus, oral [disease/finding] olp - oral lichen planus oral lichen planus (disorder) |
| UMLS | C0206139 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:23) C0003467 | anxiety | 5 C0019196 | hepatitis c | 5 C0042769 | virus infection | 4 C0017574 | gingivitis | 4 C0011570 | depression | 3 C0019158 | hepatitis | 3 C0021053 | immune disease | 2 C0040128 | thyroid disease | 2 C0007137 | squamous cell carcinoma | 2 C0079293 | epidermolysis bullosa acquisita | 1 C0032580 | polyposis coli | 1 C0006840 | candida infection | 1 C0008049 | varicella | 1 C0006840 | candidiasis | 1 C0019163 | hepatitis b | 1 C0032580 | adenomatous polyposis coli | 1 C0014527 | epidermolysis bullosa | 1 C0948265 | metabolic syndrome | 1 C0036202 | sarcoidosis | 1 C0031099 | periodontitis | 1 C0007570 | celiac disease | 1 C0019360 | zoster | 1 C0026640 | oral cancer | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:22) 1557 | CYP2C19 | infer 1559 | CYP2C9 | infer 1565 | CYP2D6 | infer 2204 | FCAR | infer 2212 | FCGR2A | infer 2213 | FCGR2B | infer 2215 | FCGR3B | infer 3458 | IFNG | infer 3586 | IL10 | infer 3552 | IL1A | infer 3553 | IL1B | infer 3557 | IL1RN | infer 3558 | IL2 | infer 3565 | IL4 | infer 3569 | IL6 | infer 4312 | MMP1 | infer 7040 | TGFB1 | infer 7124 | TNF | infer 7133 | TNFRSF1B | infer 3122 | HLA-DRA | infer 6532 | SLC6A4 | infer 7157 | TP53 | infer |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 798 |
|---|---|
| Disease | oral lichen planus |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:15) HP:0000739 | Anxiety | 5 HP:0000230 | Inflamed gums | 4 HP:0012115 | Liver inflammation | 3 HP:0000716 | Depression | 3 HP:0002860 | Squamous cell carcinoma | 2 HP:0000820 | Thyroid abnormality | 2 HP:0002960 | Autoimmune condition | 2 HP:0012531 | Pain | 2 HP:0030731 | Carcinoma | 2 HP:0002608 | Celiac disease | 1 HP:0002721 | Immunodeficiency | 1 HP:0002745 | Oral idiopathic leukoplakia | 1 HP:0000704 | Pyorrhea | 1 HP:0200123 | Chronic liver inflammation | 1 HP:0000708 | Behavioral problems | 1 |
| Disease ID | 798 |
|---|---|
| Disease | oral lichen planus |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:15) C2598155 | pain C2364133 | infection C1608408 | malignant transformation C1510471 | vitamin deficiencies C1373218 | immunosuppression C0950124 | papillomavirus infection C0878500 | epithelial dysplasia C0276680 | candida albicans infection C0220641 | oral cancer C0085860 | polyglandular autoimmune syndrome type ii C0042769 | virus infection C0029166 | oral manifestations C0023895 | hepatic disease C0017577 | desquamative gingivitis C0011849 | diabetes mellitus |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0009450 | infection | 7 C0042769 | virus infection | 4 C1608408 | malignant transformation | 3 C0017577 | desquamative gingivitis | 2 C0030193 | pain | 2 C0026640 | oral cancer | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs3775291 | 24028589 | 7097 | TLR2 | umls:C0206139 | BeFree | No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. | 0.00408156 | 2013 | TLR3 | 4 | 186082920 | C | T,G |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0206139 | tretinoin | D014212 | 302-79-4 | lichen planus, oral | MESH:D017676 | therapeutic | 4685585 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |