PedAM

Pediatric Disease Annotations & Medicines


	onchocerciasis

Disease ID	449
Disease	onchocerciasis
Definition	Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Synonym	infection by onchocerca volvulus infection by onchocerca volvulus (disorder) infection caused by onchocerca volvulus infection caused by onchocerca volvulus (disorder) onchocerca volvulus infection onchocerciases onchocerciasis [disease/finding] onchocercosis river blindness volvulosis
Orphanet	ORPHANET:2737
DOID	DOID:11678 DOID:11680
UMLS	C0029001
MeSH	D009855
SNOMED-CT	SNOMEDCT_US_2016_09_01:38539003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:10) C0456909 \| blindness \| 6 C0014544 \| epilepsy \| 3 C0023968 \| loiasis \| 2 C0013884 \| lymphatic filariasis \| 1 C0016085 \| filariasis \| 1 C0036323 \| schistosomiasis \| 1 C0042961 \| volvulus \| 1 C0040592 \| trachoma \| 1 C0010034 \| corneal disease \| 1 C0010034 \| corneal diseases \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 2212 \| FCGR2A \| infer 3596 \| IL13 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:118) 2288 \| FKBP4 \| DISEASES 10942 \| PRSS21 \| DISEASES 3560 \| IL2RB \| DISEASES 6361 \| CCL17 \| DISEASES 10423 \| CDIPT \| DISEASES 973 \| CD79A \| DISEASES 6369 \| CCL24 \| DISEASES 5949 \| RBP3 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 8288 \| EPX \| DISEASES 23729 \| SHPK \| DISEASES 6357 \| CCL13 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 1432 \| MAPK14 \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 5534 \| PPP3R1 \| DISEASES 80306 \| MED28 \| DISEASES 8192 \| CLPP \| DISEASES 6351 \| CCL4 \| DISEASES 6737 \| TRIM21 \| DISEASES 5959 \| RDH5 \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 9043 \| SPAG9 \| DISEASES 3959 \| LGALS3BP \| DISEASES 2208 \| FCER2 \| DISEASES 175 \| AGA \| DISEASES 80725 \| SRCIN1 \| DISEASES 80321 \| CEP70 \| DISEASES 1950 \| EGF \| DISEASES 3001 \| GZMA \| DISEASES 4841 \| NONO \| DISEASES 3176 \| HNMT \| DISEASES 3081 \| HGD \| DISEASES 6352 \| CCL5 \| DISEASES 6359 \| CCL15 \| DISEASES 6368 \| CCL23 \| DISEASES 27306 \| HPGDS \| DISEASES 79753 \| SNIP1 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 25798 \| BRI3 \| DISEASES 94274 \| PPP1R14A \| DISEASES 56947 \| MFF \| DISEASES 6356 \| CCL11 \| DISEASES 6037 \| RNASE3 \| DISEASES 6036 \| RNASE2 \| DISEASES 5729 \| PTGDR \| DISEASES 3596 \| IL13 \| DISEASES 23592 \| LEMD3 \| DISEASES 27165 \| GLS2 \| DISEASES 27235 \| COQ2 \| DISEASES 9885 \| OSBPL2 \| DISEASES 4351 \| MPI \| DISEASES 811 \| CALR \| DISEASES 9033 \| PKD2L1 \| DISEASES 8784 \| TNFRSF18 \| DISEASES 1946 \| EFNA5 \| DISEASES 255324 \| EPGN \| DISEASES 340075 \| ARSI \| DISEASES 5269 \| SERPINB6 \| DISEASES 3141 \| HLCS \| DISEASES 3329 \| HSPD1 \| DISEASES 81545 \| FBXO38 \| DISEASES 8073 \| PTP4A2 \| DISEASES 10516 \| FBLN5 \| DISEASES 347 \| APOD \| DISEASES 84706 \| GPT2 \| DISEASES 5265 \| SERPINA1 \| DISEASES 287 \| ANK2 \| DISEASES 26136 \| TES \| DISEASES 404552 \| SCGB1D4 \| DISEASES 51150 \| SDF4 \| DISEASES 58484 \| NLRC4 \| DISEASES 4512 \| MT-CO1 \| DISEASES 9374 \| PPT2 \| DISEASES 4540 \| MT-ND5 \| DISEASES 25802 \| LMOD1 \| DISEASES 3459 \| IFNGR1 \| DISEASES 962 \| CD48 \| DISEASES 6280 \| S100A9 \| DISEASES 84816 \| RTN4IP1 \| DISEASES 2805 \| GOT1 \| DISEASES 959 \| CD40LG \| DISEASES 5900 \| RALGDS \| DISEASES 7099 \| TLR4 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 116511 \| MAS1L \| DISEASES 6354 \| CCL7 \| DISEASES 23408 \| SIRT5 \| DISEASES 6541 \| SLC7A1 \| DISEASES 10333 \| TLR6 \| DISEASES 390874 \| ONECUT3 \| DISEASES 2235 \| FECH \| DISEASES 440163 \| RNASE13 \| DISEASES 114609 \| TIRAP \| DISEASES 12 \| SERPINA3 \| DISEASES 9560 \| CCL4L2 \| DISEASES 2875 \| GPT \| DISEASES 8995 \| TNFSF18 \| DISEASES 3778 \| KCNMA1 \| DISEASES 210 \| ALAD \| DISEASES 6295 \| SAG \| DISEASES 55636 \| CHD7 \| DISEASES 6503 \| SLA \| DISEASES 83876 \| MRO \| DISEASES 7124 \| TNF \| DISEASES 2821 \| GPI \| DISEASES 3586 \| IL10 \| DISEASES 23218 \| NBEAL2 \| DISEASES 5542 \| PRB1 \| DISEASES 11331 \| PHB2 \| DISEASES 246744 \| STH \| DISEASES
Locus	(Waiting for update.)

Disease ID	449
Disease	onchocerciasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:5) HP:0000618 \| Blindness \| 6 HP:0002580 \| Volvulus \| 1 HP:0001482 \| Subcutaneous nodule \| 1 HP:0001250 \| Seizures \| 1 HP:0009903 \| Conjunctival nodule \| 1

Disease ID	449
Disease	onchocerciasis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:27) C2707258 \| infections C2364133 \| infection C2240374 \| eosinophilia C1689996 \| eosinopenia C1096087 \| mazzotti reaction C0456909 \| blindness C0339383 \| chorioretinopathy C0235272 \| retinal damage C0042961 \| volvulus C0037285 \| skin manifestations C0037284 \| skin lesions C0037274 \| skin disease C0036454 \| visual field defects C0035309 \| retinal disease C0033774 \| pruritus C0033774 \| itching C0029132 \| optic neuropathy C0029132 \| optic nerve disease C0023348 \| lepromatous leprosy C0018418 \| gynaecomastia C0015411 \| eye manifestations C0015397 \| ocular disease C0015397 \| eye disease C0014544 \| epilepsy C0013884 \| lymphatic filariasis C0013882 \| elephantiasis C0008513 \| chorioretinitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0456909 \| blindness \| 6 C0014544 \| epilepsy \| 3 C0021311 \| infections \| 2 C0042961 \| volvulus \| 1 C0033774 \| itching \| 1 C0013884 \| lymphatic filariasis \| 1 C0009450 \| infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0029001	albendazole	D015766	54965-21-8	onchocerciasis	MESH:D009855	therapeutic	1796233
C0029001	ivermectin	D007559	70288-86-7	onchocerciasis	MESH:D009855	therapeutic	15993957

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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