PedAM

Pediatric Disease Annotations & Medicines


	oligohydramnios

Disease ID	1278
Disease	oligohydramnios
Definition	A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.
Synonym	deficient liquor oligohydramnios (disorder) oligohydramnios [disease/finding] oligohydramnios nos oligohydramnios nos (disorder) oligohydramnios unspecified oligohydramnios unspecified (disorder) oligohydramnios, nos reduced amniotic fluid reduced liquor volume scanty liquor
DOID	DOID:12215
UMLS	C0079924
MeSH	D016104
SNOMED-CT	SNOMEDCT_US_2016_09_01:59566000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C0003460 \| anuria \| 5 C0022876 \| preterm labor \| 3 C0011847 \| diabetes \| 2 C0013537 \| eclampsia \| 1 C0011849 \| diabetes mellitus \| 1 C0020224 \| polyhydramnios \| 1 C0334684 \| renal adenoma \| 1 C0206667 \| adrenal adenoma \| 1 C0020295 \| hydronephrosis \| 1 C0000832 \| placental abruption \| 1 C0008495 \| chorioamnionitis \| 1 C0032051 \| placental insufficiency \| 1 C0011848 \| diabetes insipidus \| 1 C1565489 \| renal insufficiency \| 1 C0020538 \| hypertensive disorder \| 1 C1145670 \| respiratory failure \| 1 C0032914 \| preeclampsia \| 1 C0000832 \| abruptio placenta \| 1 C0001430 \| adenoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 3557 \| IL1RN \| infer 5743 \| PTGS2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:104) 3956 \| LGALS1 \| DISEASES 57167 \| SALL4 \| DISEASES 5020 \| OXT \| DISEASES 412 \| STS \| DISEASES 343 \| AQP8 \| DISEASES 366 \| AQP9 \| DISEASES 1592 \| CYP26A1 \| DISEASES 6928 \| HNF1B \| DISEASES 4621 \| MYH3 \| DISEASES 55907 \| CMAS \| DISEASES 4317 \| MMP8 \| DISEASES 6909 \| TBX2 \| DISEASES 9496 \| TBX4 \| DISEASES 7389 \| UROD \| DISEASES 3630 \| INS \| DISEASES 10343 \| PKDREJ \| DISEASES 729330 \| OC90 \| DISEASES 57045 \| TWSG1 \| DISEASES 3977 \| LIFR \| DISEASES 23530 \| NNT \| DISEASES 80144 \| FRAS1 \| DISEASES 5972 \| REN \| DISEASES 26154 \| ABCA12 \| DISEASES 341640 \| FREM2 \| DISEASES 124540 \| MSI2 \| DISEASES 1525 \| CXADR \| DISEASES 4838 \| NODAL \| DISEASES 1636 \| ACE \| DISEASES 5739 \| PTGIR \| DISEASES 327 \| APEH \| DISEASES 364 \| AQP7 \| DISEASES 360 \| AQP3 \| DISEASES 9317 \| PTER \| DISEASES 79053 \| ALG8 \| DISEASES 3479 \| IGF1 \| DISEASES 43 \| ACHE \| DISEASES 2720 \| GLB1 \| DISEASES 2733 \| GLE1 \| DISEASES 54715 \| RBFOX1 \| DISEASES 30008 \| EFEMP2 \| DISEASES 27165 \| GLS2 \| DISEASES 358 \| AQP1 \| DISEASES 54968 \| TMEM70 \| DISEASES 133522 \| PPARGC1B \| DISEASES 11238 \| CA5B \| DISEASES 1442 \| CSH1 \| DISEASES 147912 \| SIX5 \| DISEASES 9475 \| ROCK2 \| DISEASES 64388 \| GREM2 \| DISEASES 282679 \| AQP11 \| DISEASES 6888 \| TALDO1 \| DISEASES 10615 \| SPAG5 \| DISEASES 1303 \| COL12A1 \| DISEASES 5069 \| PAPPA \| DISEASES 5587 \| PRKD1 \| DISEASES 9402 \| GRAP2 \| DISEASES 5078 \| PAX4 \| DISEASES 8481 \| OFD1 \| DISEASES 285489 \| DOK7 \| DISEASES 10516 \| FBLN5 \| DISEASES 5154 \| PDGFA \| DISEASES 1717 \| DHCR7 \| DISEASES 5979 \| RET \| DISEASES 26503 \| SLC17A5 \| DISEASES 871 \| SERPINH1 \| DISEASES 5742 \| PTGS1 \| DISEASES 183 \| AGT \| DISEASES 5743 \| PTGS2 \| DISEASES 1892 \| ECHS1 \| DISEASES 959 \| CD40LG \| DISEASES 5737 \| PTGFR \| DISEASES 6005 \| RHAG \| DISEASES 5476 \| CTSA \| DISEASES 27286 \| SRPX2 \| DISEASES 90550 \| MCU \| DISEASES 7321 \| UBE2D1 \| DISEASES 2268 \| FGR \| DISEASES 10082 \| GPC6 \| DISEASES 8573 \| CASK \| DISEASES 9731 \| CEP104 \| DISEASES 4868 \| NPHS1 \| DISEASES 375790 \| AGRN \| DISEASES 1645 \| AKR1C1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 1146 \| CHRNG \| DISEASES 54828 \| BCAS3 \| DISEASES 55054 \| ATG16L1 \| DISEASES 3239 \| HOXD13 \| DISEASES 1443 \| CSH2 \| DISEASES 54903 \| MKS1 \| DISEASES 685 \| BTC \| DISEASES 174 \| AFP \| DISEASES 4668 \| NAGA \| DISEASES 92002 \| FAM58A \| DISEASES 91147 \| TMEM67 \| DISEASES 3481 \| IGF2 \| DISEASES 6915 \| TBXA2R \| DISEASES 8399 \| PLA2G10 \| DISEASES 5076 \| PAX2 \| DISEASES 196527 \| ANO6 \| DISEASES 51259 \| TMEM216 \| DISEASES 5228 \| PGF \| DISEASES 567 \| B2M \| DISEASES 10984 \| KCNQ1OT1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1278
Disease	oligohydramnios
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0002089 \| Hypoplastic lungs \| 8 HP:0100519 \| Anuria \| 5 HP:0000105 \| Renal enlargement \| 2 HP:0000021 \| Megacystis \| 2 HP:0001788 \| Premature rupture of membranes \| 2 HP:0001561 \| Hydramnios \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0000104 \| Renal agenesis \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0002804 \| Arthrogryposis multiplex congenita \| 1 HP:0011419 \| Abruptio placentae \| 1 HP:0100790 \| Hernia \| 1 HP:0001511 \| Prenatal onset growth retardation \| 1 HP:0100602 \| Pre-eclampsia \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0100603 \| Toxemia of pregnancy \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0100601 \| Eclampsia \| 1 HP:0000126 \| Hydronephrosis \| 1

Disease ID	1278
Disease	oligohydramnios
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0021308 \| infarction \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0079924	enalapril	D004656	75847-73-3	oligohydramnios	MESH:D016104	marker/mechanism	16147831
C0079924	indomethacin	D007213	53-86-1	oligohydramnios	MESH:D016104	marker/mechanism	1923225
C0079924	piroxicam	D010894	36322-90-4	oligohydramnios	MESH:D016104	marker/mechanism	7819009

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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