PedAM

Pediatric Disease Annotations & Medicines


	ocular hypertension

Disease ID	677
Disease	ocular hypertension
Definition	A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
Synonym	hypertension ocular hypertension, ocular hypertensions, ocular ocular hypertension (disorder) ocular hypertension [disease/finding] ocular hypertensions oh - ocular hypertension oht - ocular hypertension pressure behind eyeballs
DOID	DOID:9282
UMLS	C0028840
MeSH	D009798
SNOMED-CT	SNOMEDCT_US_2016_09_01:4210003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:30) C0017601 \| glaucoma \| 21 C0017612 \| open-angle glaucoma \| 10 C0339573 \| primary open-angle glaucoma \| 4 C0042164 \| uveitis \| 3 C0339573 \| primary open angle glaucoma \| 2 C0042165 \| anterior uveitis \| 2 C0011847 \| diabetes \| 2 C0339572 \| steroid responders \| 2 C0456909 \| blindness \| 2 C0017612 \| open angle glaucoma \| 2 C0442874 \| neuropathy \| 1 C1271398 \| pigment dispersion syndrome \| 1 C0036454 \| visual field defects \| 1 C0020581 \| hyphema \| 1 C0017606 \| primary angle closure glaucoma \| 1 C0035305 \| retinal detachment \| 1 C0017605 \| angle closure glaucoma \| 1 C0152136 \| normal tension glaucoma \| 1 C0019348 \| herpes simplex \| 1 C0154841 \| central retinal vein occlusion \| 1 C0339143 \| graves' ophthalmopathy \| 1 C0035328 \| retinal vein occlusion \| 1 C0154946 \| acute angle closure glaucoma \| 1 C0011884 \| diabetic retinopathy \| 1 C0042164 \| intraocular inflammation \| 1 C0036454 \| visual field defect \| 1 C0014236 \| endophthalmitis \| 1 C0086543 \| cataract \| 1 C0029132 \| optic neuropathy \| 1 C0022116 \| ischemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) MMP1 \| 4312 \| CTD_human NR3C1 \| 2908 \| CTD_human DDIT3 \| 1649 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 4653 \| MYOC \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:228) 4653 \| MYOC \| DISEASES 4804 \| NGFR \| DISEASES 440 \| ASNS \| DISEASES 368 \| ABCC6 \| DISEASES 7494 \| XBP1 \| DISEASES 410 \| ARSA \| DISEASES 49 \| ACR \| DISEASES 1690 \| COCH \| DISEASES 1591 \| CYP24A1 \| DISEASES 6445 \| SGCG \| DISEASES 10562 \| OLFM4 \| DISEASES 6530 \| SLC6A2 \| DISEASES 366 \| AQP9 \| DISEASES 6422 \| SFRP1 \| DISEASES 27294 \| DHDH \| DISEASES 5216 \| PFN1 \| DISEASES 51166 \| AADAT \| DISEASES 4848 \| CNOT2 \| DISEASES 7167 \| TPI1 \| DISEASES 113246 \| C12orf57 \| DISEASES 8683 \| SRSF9 \| DISEASES 9450 \| LY86 \| DISEASES 5459 \| POU4F3 \| DISEASES 2908 \| NR3C1 \| DISEASES 1509 \| CTSD \| DISEASES 55640 \| FLVCR2 \| DISEASES 63923 \| TNN \| DISEASES 2693 \| GHSR \| DISEASES 5732 \| PTGER2 \| DISEASES 4974 \| OMG \| DISEASES 64428 \| NARFL \| DISEASES 27112 \| FAM155B \| DISEASES 2670 \| GFAP \| DISEASES 6538 \| SLC6A11 \| DISEASES 23378 \| RRP8 \| DISEASES 759 \| CA1 \| DISEASES 51124 \| IER3IP1 \| DISEASES 2947 \| GSTM3 \| DISEASES 90070 \| LACRT \| DISEASES 6610 \| SMPD2 \| DISEASES 27348 \| TOR1B \| DISEASES 1545 \| CYP1B1 \| DISEASES 3290 \| HSD11B1 \| DISEASES 59341 \| TRPV4 \| DISEASES 4016 \| LOXL1 \| DISEASES 4591 \| TRIM37 \| DISEASES 9093 \| DNAJA3 \| DISEASES 3249 \| HPN \| DISEASES 25939 \| SAMHD1 \| DISEASES 10133 \| OPTN \| DISEASES 1326 \| MAP3K8 \| DISEASES 57084 \| SLC17A6 \| DISEASES 6855 \| SYP \| DISEASES 3977 \| LIFR \| DISEASES 55850 \| USE1 \| DISEASES 941 \| CD80 \| DISEASES 2891 \| GRIA2 \| DISEASES 5276 \| SERPINI2 \| DISEASES 411 \| ARSB \| DISEASES 2121 \| EVC \| DISEASES 11063 \| SOX30 \| DISEASES 6507 \| SLC1A3 \| DISEASES 55716 \| LMBR1L \| DISEASES 6017 \| RLBP1 \| DISEASES 207 \| AKT1 \| DISEASES 2041 \| EPHA1 \| DISEASES 4915 \| NTRK2 \| DISEASES 79175 \| ZNF343 \| DISEASES 932 \| MS4A3 \| DISEASES 5458 \| POU4F2 \| DISEASES 6695 \| SPOCK1 \| DISEASES 2893 \| GRIA4 \| DISEASES 22934 \| RPIA \| DISEASES 760 \| CA2 \| DISEASES 114 \| ADCY8 \| DISEASES 6529 \| SLC6A1 \| DISEASES 8321 \| FZD1 \| DISEASES 57798 \| GATAD1 \| DISEASES 2176 \| FANCC \| DISEASES 9669 \| EIF5B \| DISEASES 1409 \| CRYAA \| DISEASES 1173 \| AP2M1 \| DISEASES 8927 \| BSN \| DISEASES 364 \| AQP7 \| DISEASES 58157 \| NGB \| DISEASES 2619 \| GAS1 \| DISEASES 161742 \| SPRED1 \| DISEASES 26585 \| GREM1 \| DISEASES 147945 \| NLRP4 \| DISEASES 55872 \| PBK \| DISEASES 598 \| BCL2L1 \| DISEASES 5734 \| PTGER4 \| DISEASES 3094 \| HINT1 \| DISEASES 136 \| ADORA2B \| DISEASES 2915 \| GRM5 \| DISEASES 2353 \| FOS \| DISEASES 3777 \| KCNK3 \| DISEASES 56246 \| MRAP \| DISEASES 2752 \| GLUL \| DISEASES 134 \| ADORA1 \| DISEASES 763 \| CA5A \| DISEASES 26502 \| NARF \| DISEASES 836 \| CASP3 \| DISEASES 131450 \| CD200R1 \| DISEASES 5870 \| RAB6A \| DISEASES 1427 \| CRYGS \| DISEASES 713 \| C1QB \| DISEASES 8630 \| HSD17B6 \| DISEASES 10954 \| PDIA5 \| DISEASES 23362 \| PSD3 \| DISEASES 3309 \| HSPA5 \| DISEASES 342898 \| SYCN \| DISEASES 284359 \| IZUMO1 \| DISEASES 221937 \| FOXK1 \| DISEASES 2242 \| FES \| DISEASES 1538 \| CYLC1 \| DISEASES 2049 \| EPHB3 \| DISEASES 135 \| ADORA2A \| DISEASES 468 \| ATF4 \| DISEASES 55775 \| TDP1 \| DISEASES 57142 \| RTN4 \| DISEASES 2289 \| FKBP5 \| DISEASES 6540 \| SLC6A13 \| DISEASES 3985 \| LIMK2 \| DISEASES 5549 \| PRELP \| DISEASES 1003 \| CDH5 \| DISEASES 5170 \| PDPK1 \| DISEASES 57556 \| SEMA6A \| DISEASES 302 \| ANXA2 \| DISEASES 6890 \| TAP1 \| DISEASES 6334 \| SCN8A \| DISEASES 100506658 \| OCLN \| DISEASES 84894 \| LINGO1 \| DISEASES 4010 \| LMX1B \| DISEASES 5733 \| PTGER3 \| DISEASES 57194 \| ATP10A \| DISEASES 9463 \| PICK1 \| DISEASES 5602 \| MAPK10 \| DISEASES 799 \| CALCR \| DISEASES 6539 \| SLC6A12 \| DISEASES 1002 \| CDH4 \| DISEASES 58484 \| NLRC4 \| DISEASES 4916 \| NTRK3 \| DISEASES 4976 \| OPA1 \| DISEASES 1270 \| CNTF \| DISEASES 4139 \| MARK1 \| DISEASES 7042 \| TGFB2 \| DISEASES 6646 \| SOAT1 \| DISEASES 5824 \| PEX19 \| DISEASES 3766 \| KCNJ10 \| DISEASES 93183 \| PIGM \| DISEASES 55974 \| SLC50A1 \| DISEASES 4803 \| NGF \| DISEASES 8266 \| UBL4A \| DISEASES 140 \| ADORA3 \| DISEASES 5737 \| PTGFR \| DISEASES 2778 \| GNAS \| DISEASES 6005 \| RHAG \| DISEASES 3725 \| JUN \| DISEASES 7422 \| VEGFA \| DISEASES 94233 \| OPN4 \| DISEASES 6418 \| SET \| DISEASES 6709 \| SPTAN1 \| DISEASES 26508 \| HEYL \| DISEASES 286205 \| SCAI \| DISEASES 55869 \| HDAC8 \| DISEASES 23637 \| RABGAP1 \| DISEASES 6428 \| SRSF3 \| DISEASES 26190 \| FBXW2 \| DISEASES 4153 \| MBL2 \| DISEASES 1896 \| EDA \| DISEASES 10919 \| EHMT2 \| DISEASES 199 \| AIF1 \| DISEASES 57512 \| GPR158 \| DISEASES 10218 \| ANGPTL7 \| DISEASES 5457 \| POU4F1 \| DISEASES 1910 \| EDNRB \| DISEASES 765 \| CA6 \| DISEASES 5251 \| PHEX \| DISEASES 1906 \| EDN1 \| DISEASES 8544 \| PIR \| DISEASES 2296 \| FOXC1 \| DISEASES 55504 \| TNFRSF19 \| DISEASES 361 \| AQP4 \| DISEASES 56953 \| NT5M \| DISEASES 54499 \| TMCO1 \| DISEASES 55188 \| RIC8B \| DISEASES 2869 \| GRK5 \| DISEASES 10018 \| BCL2L11 \| DISEASES 2596 \| GAP43 \| DISEASES 6430 \| SRSF5 \| DISEASES 4501 \| MT1X \| DISEASES 6046 \| BRD2 \| DISEASES 2047 \| EPHB1 \| DISEASES 1415 \| CRYBB2 \| DISEASES 4905 \| NSF \| DISEASES 54826 \| GIN1 \| DISEASES 1837 \| DTNA \| DISEASES 3778 \| KCNMA1 \| DISEASES 136371 \| ASB10 \| DISEASES 57448 \| BIRC6 \| DISEASES 3776 \| KCNK2 \| DISEASES 29843 \| SENP1 \| DISEASES 387836 \| CLEC2A \| DISEASES 50863 \| NTM \| DISEASES 8848 \| TSC22D1 \| DISEASES 387 \| RHOA \| DISEASES 93649 \| MYOCD \| DISEASES 4140 \| MARK3 \| DISEASES 627 \| BDNF \| DISEASES 56244 \| BTNL2 \| DISEASES 6171 \| RPL41 \| DISEASES 134430 \| WDR36 \| DISEASES 11275 \| KLHL2 \| DISEASES 346007 \| EYS \| DISEASES 149466 \| C1orf210 \| DISEASES 23741 \| EID1 \| DISEASES 4914 \| NTRK1 \| DISEASES 26298 \| EHF \| DISEASES 100431172 \| KLRF2 \| DISEASES 83857 \| TMTC1 \| DISEASES 8284 \| KDM5D \| DISEASES 1649 \| DDIT3 \| DISEASES 5228 \| PGF \| DISEASES 4782 \| NFIC \| DISEASES 3292 \| HSD17B1 \| DISEASES 8740 \| TNFSF14 \| DISEASES 348120 \| LINC01193 \| DISEASES
Locus	(Waiting for update.)

Disease ID	677
Disease	ocular hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0000501 \| Glaucoma \| 21 HP:0000554 \| Uveitis \| 3 HP:0012122 \| Anterior uveitis \| 2 HP:0000618 \| Blindness \| 2 HP:0012108 \| Primary open angle glaucoma \| 2 HP:0000541 \| Detached retina \| 1 HP:0001123 \| Partial loss of field of vision \| 1 HP:0012109 \| Primary angle closure glaucoma \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0011886 \| Hyphema \| 1 HP:0012636 \| Retinal vein occlusion \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0000518 \| Cataract \| 1

Disease ID	677
Disease	ocular hypertension
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0017601 \| glaucoma \| 21 C0021888 \| intraocular pressure \| 11 C0339573 \| primary open angle glaucoma \| 2 C0036454 \| visual field defects \| 1 C0154841 \| central retinal vein occlusion \| 1 C0856169 \| endothelial dysfunction \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs6195	17563720	2908	NR3C1	umls:C0028840	BeFree	The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy.	0.123267234	2007	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:71)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	163449989	rs10917773	C	T	rs10917773	23836780	9.32E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs10917773-T	Research Support, Non-U.S. Gov't
1	165687205	rs4656461	G	A	rs4656461	22570627	9.60E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165687205	rs4656461	G	A	rs4656461	24002674	8.30E-07	NA	0.9	[0.51-1.29] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs4656461-G	Research Support, N.I.H., Extramural
1	165694897	rs7524755	T	C	rs7524755	22570627	7.80E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165695855	rs6660601	C	T	rs6660601	22570627	7.50E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165707923	rs6696454	T	C	rs6696454	22570627	6.40E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165718979	rs7555523	C	A	rs7555523	22570627	2.00E-08	NA	0.28	[0.18-0.37] mmHg increase	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs7555523-C	Research Support, N.I.H., Extramural
1	165718979	rs7555523	C	A	rs7555523	23836780	1.88E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs7555523-C	Research Support, Non-U.S. Gov't
1	165732661	rs4657476	C	T	rs4657476	22570627	6.40E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165736880	rs7518099	C	T	rs7518099	22570627	7.80E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165736880	rs7518099	C	T	rs7518099	23836780	1.04E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs7518099-C	Research Support, Non-U.S. Gov't
1	165736880	rs7518099	C	T	rs7518099	24002674	8.00E-08	NA	0.94	[0.55-1.33] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs7518099-G	Research Support, N.I.H., Extramural
1	165737704	rs2790053	C	G	rs2790053	22570627	7.70E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165738311	rs2251768	A	T	rs2251768	22570627	7.70E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165738463	rs2790052	G	C	rs2790052	22570627	7.60E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
1	165739598	rs2814471	C	T	rs2814471	22570627	7.40E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
2	206719553	rs6745633	T	C	rs6745633	22570627	5.70E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	18408096	rs9713190	T	C	rs9713190	22570627	9.60E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	18408930	rs9837588	A	G	rs9837588	22570627	9.40E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	18409067	rs9879688	G	A	rs9879688	22570627	9.20E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	18409077	rs9841621	A	G	rs9841621	22570627	1.00E-04	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	18409169	rs9879573	C	T	rs9879573	22570627	9.20E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	70850461	rs2117760	C	A	rs2117760	22570627	5.50E-04	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
3	71055162	rs13093086	G	A	rs13093086	24002674	5.00E-06	NA	0.57	[0.30-0.84] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs13093086-A	Research Support, N.I.H., Extramural
4	5841350	rs16837723	A	G	rs16837723	23836780	3.05E-05	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs16837723-G	Research Support, Non-U.S. Gov't
4	7863508	rs4383619	T	C	rs4383619	24002674	1.30E-05	NA	0.55	[0.22-0.88] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs4383619-A	Research Support, N.I.H., Extramural
4	7917806	rs6838291	C	T	rs6838291	24002674	1.00E-05	NA	0.59	[0.24-0.94] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs6838291-A	Research Support, N.I.H., Extramural
4	7931682	rs11930623	A	C	rs11930623	24002674	1.30E-05	NA	0.63	[0.36-0.9] unit decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs11930623-C	Research Support, N.I.H., Extramural
4	182638513	rs6848193	A	G	rs6848193	24002674	1.50E-05	NA	0.47	[0.2-0.74] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs6848193-A	Research Support, N.I.H., Extramural
5	149445921	rs216146	T	C	rs216146	22570627	3.70E-04	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
5	149447628	rs216150	A	G	rs216150	22570627	2.70E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
6	51622449	rs2025751	T	C	rs2025751	24002674	7.00E-07	NA	0.6	[0.33-0.87] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs2025751-A	Research Support, N.I.H., Extramural
6	136505036	rs560713	A	C	rs560713	24002674	2.00E-06	NA	0.53	[0.24-0.82] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs560713-A	Research Support, N.I.H., Extramural
7	8150990	rs13227590	A	G	rs13227590	23836780	8.25E-08	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs13227590-G	Research Support, Non-U.S. Gov't
7	8152067	rs59072263	G	T	rs59072263	23836780	1.00E-08	GWAS+replication1+2	0.45	[0.29-0.61] unit increase	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs59072263-G	Research Support, Non-U.S. Gov't
7	89970723	rs42639	G	A	rs42639	22570627	1.90E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
8	118089513	rs7815720	G	A	rs7815720	24002674	2.00E-06	NA	1.02	[0.61-1.43] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs7815720-A	Research Support, N.I.H., Extramural
8	134615750	rs2945733	T	G	rs2945733	24002674	4.00E-06	NA	0.51	[0.098-0.922] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs2945733-A	Research Support, N.I.H., Extramural
9	35424038	rs17370022	A	G	rs17370022	23836780	4.56E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs17370022-A	Research Support, Non-U.S. Gov't
9	35438294	rs17298052	G	C	rs17298052	23836780	4.56E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs17298052-G	Research Support, Non-U.S. Gov't
9	35439386	rs17370251	T	C	rs17370251	23836780	4.56E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs17370251-T	Research Support, Non-U.S. Gov't
9	129246487	rs2286885	A	C	rs2286885	24518671	6.00E-06	NA	0.12	[0.07-0.18] mmHg increase	2,774 European ancestry individuals	European(2774)	ALL(2774)	EUR(2774)	ALL(2774)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs2286885-A	Twin Study
10	36455895	rs315644	C	A	rs315644	24002674	1.20E-05	NA	0.59	[0.26-0.92] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs315644-C	Research Support, N.I.H., Extramural
10	88528362	rs12772861	T	C	rs12772861	22570627	1.00E-05	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88601610	rs4114847	G	A	rs4114847	22570627	7.20E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88603145	rs12762647	C	G	rs12762647	22570627	7.20E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88605242	rs17107107	C	T	rs17107107	22570627	5.60E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88606938	rs11814254	G	A	rs11814254	22570627	7.10E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88613110	rs12243345	A	G	rs12243345	22570627	8.00E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88616531	rs12778494	T	C	rs12778494	22570627	8.50E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	88618624	rs7894966	T	G	rs7894966	22570627	3.00E-06	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
10	124749965	rs3736580	C	T	rs3736580	23836780	1.26E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs3736580-T	Research Support, Non-U.S. Gov't
10	124753060	rs9423302	G	A	rs9423302	23836780	4.25E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs9423302-A	Research Support, Non-U.S. Gov't
11	41182519	rs10430986	T	C	rs10430986	23836780	2.63E-06	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs10430986-C	Research Support, Non-U.S. Gov't
11	41187859	rs12222492	C	T	rs12222492	23836780	8.68E-06	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs12222492-T	Research Support, Non-U.S. Gov't
11	92388582	rs6483184	G	C	rs6483184	22570627	2.40E-07	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
14	22078529	rs10047948	A	G	rs10047948	24002674	1.70E-05	NA	0.73	[0.3-1.16] unit decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs10047948-G	Research Support, N.I.H., Extramural
14	22235890	rs718433	G	A	rs718433	24002674	8.00E-06	NA	0.59	[0.32-0.86] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs718433-G	Research Support, N.I.H., Extramural
14	45169289	rs807331	C	T	rs807331	24002674	1.60E-05	NA	0.5	[0.19-0.81] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs807331-G	Research Support, N.I.H., Extramural
14	101978769	rs3818077	A	G	rs3818077	23836780	1.41E-04	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs3818077-A	Research Support, Non-U.S. Gov't
14	101979288	rs3818079	G	A	rs3818079	23836780	9.99E-06	GWAS+replication1	NA	NA	2,175 European ancestry individuals	European(2175)	ALL(2175)	EUR(2175)	ALL(2175)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs3818079-G	Research Support, Non-U.S. Gov't
15	37630365	rs4924148	T	C	rs4924148	24002674	4.90E-06	NA	0.73	[0.44-1.02] unit decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs4924148-G	Research Support, N.I.H., Extramural
15	37660049	rs587847	C	A	rs587847	24002674	1.00E-06	NA	0.69	[0.42-0.96] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs587847-C	Research Support, N.I.H., Extramural
15	37675583	rs603165	C	T	rs603165	24002674	1.50E-05	NA	0.62	[0.35-0.89] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs603165-A	Research Support, N.I.H., Extramural
16	6108430	rs1906060	C	T	rs1906060	24002674	4.00E-06	NA	0.59	[0.24-0.94] mmHg increase	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs1906060-G	Research Support, N.I.H., Extramural
16	77572955	rs1826598	C	A	rs1826598	22570627	5.40E-07	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
17	10031090	rs12150284	C	T	rs12150284	22570627	2.50E-08	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
17	10031090	rs12150284	C	T	rs12150284	24002674	2.00E-06	NA	0.62	[0.33-0.91] mmHg decrease	2,847 European ancestry primary open angle glaucoma cases; 3,389 European ancestry controls	European(6236)	ALL(6236)	EUR(6236)	ALL(6236)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs12150284-A	Research Support, N.I.H., Extramural
17	10031183	rs9913911	A	G	rs9913911	22570627	2.40E-08	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural
17	10033679	rs11656696	C	A	rs11656696	22570627	1.00E-08	NA	0.19	[0.12-0.26] mmHg decrease	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	rs11656696-A	Research Support, N.I.H., Extramural
17	10035337	rs9889528	C	T	rs9889528	22570627	2.10E-08	NA	NA	NA	11,972 European ancestry individuals	European(11972)	ALL(11972)	EUR(11972)	ALL(11972)	Intraocular pressure	HPOID:0007906	HPOID:0008007	Increased intraocular pressure	Primary congenital glaucoma	DOID:1686	glaucoma	D009798	Ocular Hypertension	EFOID:0004695	intraocular pressure measurement	Glaucoma	NA	Research Support, N.I.H., Extramural

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:16)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0028840	betamethasone	D001623	378-44-9	ocular hypertension	MESH:D009798	marker/mechanism	9435188
C0028840	caffeine	D002110	1958/8/2	ocular hypertension	MESH:D009798	marker/mechanism	9442454
C0028840	carteolol	D002354	51781-06-7	ocular hypertension	MESH:D009798	therapeutic	8145982
C0028840	diclofenac	D004008	15307-86-5	ocular hypertension	MESH:D009798	therapeutic	14609909
C0028840	diltiazem	D004110	42399-41-7	ocular hypertension	MESH:D009798	therapeutic	9435188
C0028840	dipivefrin	C015173	52365-63-6	ocular hypertension	MESH:D009798	therapeutic	517603
C0028840	fluocinolone acetonide	D005446	67-73-2	ocular hypertension	MESH:D009798	marker/mechanism	15767049
C0028840	fluorometholone	D005469	426-13-1	ocular hypertension	MESH:D009798	marker/mechanism	10088814
C0028840	metoprolol	D008790	37350-58-6	ocular hypertension	MESH:D009798	therapeutic	7010891
C0028840	norepinephrine	D009638	51-41-2	ocular hypertension	MESH:D009798	therapeutic	1138682
C0028840	phenylephrine	D010656	59-42-7	ocular hypertension	MESH:D009798	marker/mechanism	19295368
C0028840	pilocarpine	D010862	92-13-7	ocular hypertension	MESH:D009798	therapeutic	18721251
C0028840	ramipril	D017257	87333-19-5	ocular hypertension	MESH:D009798	marker/mechanism	18516782
C0028840	succinylcholine	D013390	306-40-1	ocular hypertension	MESH:D009798	marker/mechanism	9659028
C0028840	timolol	D013999	26839-75-8	ocular hypertension	MESH:D009798	therapeutic	10596105
C0028840	travoprost	D000069557	-	ocular hypertension	MESH:D009798	therapeutic	19403113

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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