PedAM

Pediatric Disease Annotations & Medicines


	obstructive jaundice

Disease ID	1283
Disease	obstructive jaundice
Definition	Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
Synonym	cholestatic icterus cholestatic jaundice cholestatic jaundice syndrome cholestatic jaundice syndrome (disorder) cholestatic jaundice syndrome, nos cholestatic jaundice, nos jaundice cholestatic jaundice obstructive jaundice, cholestatic jaundice, mechanical jaundice, obstructive jaundice, obstructive [disease/finding] jaundice, regurgitation mechanical jaundice obstructive hyperbilirubinaemia obstructive hyperbilirubinemia obstructive hyperbilirubinemia (disorder) obstructive jaundice nos obstructive jaundice nos (disorder)
DOID	DOID:13603
UMLS	C0022354
MeSH	D041781
SNOMED-CT	SNOMEDCT_US_2016_09_01:44018007;SNOMEDCT_US_2016_09_01:59848001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:61) C0030305 \| pancreatitis \| 10 C0019204 \| hepatocellular carcinoma \| 9 C0206698 \| cholangiocarcinoma \| 8 C0008311 \| cholangitis \| 8 C0235974 \| pancreatic cancer \| 7 C1334028 \| hilar cholangiocarcinoma \| 6 C0024299 \| lymphoma \| 4 C0267917 \| acute cholangitis \| 4 C0854776 \| unresectable pancreatic cancer \| 3 C0024623 \| gastric cancer \| 3 C0854778 \| resectable pancreatic cancer \| 3 C0345916 \| ampullary tumor \| 2 C0031154 \| peritonitis \| 2 C0013502 \| hydatid cyst \| 2 C0701818 \| choledocholithiasis \| 2 C0024205 \| lymphadenitis \| 2 C0008350 \| cholelithiasis \| 2 C0863194 \| resectable hepatocellular carcinoma \| 2 C0039538 \| teratoma \| 2 C0235782 \| gallbladder carcinoma \| 1 C0235974 \| pancreatic carcinoma \| 1 C0010633 \| cystadenoma \| 1 C0281508 \| desmoplastic small round cell tumour \| 1 C0032131 \| plasmacytoma \| 1 C0311273 \| ascending cholangitis \| 1 C0019284 \| diaphragmatic hernia \| 1 C0541912 \| duodenal ca \| 1 C0041296 \| tuberculosis \| 1 C0149521 \| chronic pancreatitis \| 1 C0206702 \| klatskin tumor \| 1 C0346647 \| pancreatic cancers \| 1 C0008350 \| gallstone \| 1 C0008325 \| cholecystitis \| 1 C0008340 \| choledochal cyst \| 1 C0024305 \| non hodgkin lymphoma \| 1 C0699885 \| bladder carcinoma \| 1 C1333790 \| gastric teratoma \| 1 C0002726 \| amyloidosis \| 1 C0018916 \| angioma \| 1 C0010635 \| mucinous cystadenoma \| 1 C1258215 \| ileus \| 1 C0699790 \| colonic carcinoma \| 1 C0027819 \| neuroblastoma \| 1 C0162429 \| malnutrition \| 1 C0039101 \| synovial sarcoma \| 1 C0022660 \| acute renal failure \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0740457 \| renal cancer \| 1 C0278502 \| recurrent gastric cancer \| 1 C1261473 \| sarcoma \| 1 C0149925 \| small cell lung carcinoma \| 1 C0035078 \| renal failure \| 1 C0019829 \| hodgkin lymphoma \| 1 C0750952 \| biliary cancer \| 1 C0013292 \| duodenal obstruction \| 1 C0041316 \| tuberculous lymphadenitis \| 1 C0085113 \| neurofibromatosis \| 1 C0153452 \| gallbladder ca \| 1 C0023890 \| cirrhosis \| 1 C0162429 \| poor nutrition \| 1 C0079731 \| b-cell lymphoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) ABCB4 \| 5244 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:184) 1856 \| DVL2 \| DISEASES 5009 \| OTC \| DISEASES 634 \| CEACAM1 \| DISEASES 6343 \| SCT \| DISEASES 4710 \| NDUFB4 \| DISEASES 3162 \| HMOX1 \| DISEASES 1113 \| CHGA \| DISEASES 6554 \| SLC10A1 \| DISEASES 28231 \| SLCO4A1 \| DISEASES 3929 \| LBP \| DISEASES 10857 \| PGRMC1 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 3082 \| HGF \| DISEASES 4353 \| MPO \| DISEASES 30851 \| TAX1BP3 \| DISEASES 2584 \| GALK1 \| DISEASES 6347 \| CCL2 \| DISEASES 6928 \| HNF1B \| DISEASES 5539 \| PPY \| DISEASES 230 \| ALDOC \| DISEASES 51056 \| LAP3 \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 2026 \| ENO2 \| DISEASES 11334 \| TUSC2 \| DISEASES 7276 \| TTR \| DISEASES 63923 \| TNN \| DISEASES 10804 \| GJB6 \| DISEASES 6718 \| AKR1D1 \| DISEASES 583 \| BBS2 \| DISEASES 826 \| CAPNS1 \| DISEASES 92797 \| HELB \| DISEASES 2671 \| GFER \| DISEASES 2678 \| GGT1 \| DISEASES 968 \| CD68 \| DISEASES 3630 \| INS \| DISEASES 445 \| ASS1 \| DISEASES 5791 \| PTPRE \| DISEASES 1401 \| CRP \| DISEASES 6341 \| SCO1 \| DISEASES 4922 \| NTS \| DISEASES 3845 \| KRAS \| DISEASES 2922 \| GRP \| DISEASES 3569 \| IL6 \| DISEASES 9394 \| HS6ST1 \| DISEASES 1208 \| CLPS \| DISEASES 64240 \| ABCG5 \| DISEASES 10483 \| SEC23B \| DISEASES 671 \| BPI \| DISEASES 27134 \| TJP3 \| DISEASES 6855 \| SYP \| DISEASES 3553 \| IL1B \| DISEASES 8647 \| ABCB11 \| DISEASES 3931 \| LCAT \| DISEASES 1001 \| CDH3 \| DISEASES 590 \| BCHE \| DISEASES 3383 \| ICAM1 \| DISEASES 2162 \| F13A1 \| DISEASES 10058 \| ABCB6 \| DISEASES 5244 \| ABCB4 \| DISEASES 6652 \| SORD \| DISEASES 4864 \| NPC1 \| DISEASES 7157 \| TP53 \| DISEASES 150094 \| SIK1 \| DISEASES 5972 \| REN \| DISEASES 64241 \| ABCG8 \| DISEASES 91937 \| TIMD4 \| DISEASES 7082 \| TJP1 \| DISEASES 5205 \| ATP8B1 \| DISEASES 760 \| CA2 \| DISEASES 27163 \| NAAA \| DISEASES 10563 \| CXCL13 \| DISEASES 4838 \| NODAL \| DISEASES 6750 \| SST \| DISEASES 3815 \| KIT \| DISEASES 54069 \| MIS18A \| DISEASES 83932 \| SPRTN \| DISEASES 248 \| ALPI \| DISEASES 213 \| ALB \| DISEASES 5648 \| MASP1 \| DISEASES 4724 \| NDUFS4 \| DISEASES 6690 \| SPINK1 \| DISEASES 80270 \| HSD3B7 \| DISEASES 290 \| ANPEP \| DISEASES 2990 \| GUSB \| DISEASES 25928 \| SOSTDC1 \| DISEASES 6579 \| SLCO1A2 \| DISEASES 83886 \| PRSS27 \| DISEASES 2147 \| F2 \| DISEASES 5644 \| PRSS1 \| DISEASES 660 \| BMX \| DISEASES 5340 \| PLG \| DISEASES 3265 \| HRAS \| DISEASES 6868 \| ADAM17 \| DISEASES 836 \| CASP3 \| DISEASES 80227 \| PAAF1 \| DISEASES 56667 \| MUC13 \| DISEASES 4793 \| NFKBIB \| DISEASES 2580 \| GAK \| DISEASES 10170 \| DHRS9 \| DISEASES 4684 \| NCAM1 \| DISEASES 1582 \| CYP8B1 \| DISEASES 4018 \| LPA \| DISEASES 400668 \| PRSS57 \| DISEASES 387775 \| SLC22A10 \| DISEASES 26276 \| VPS33B \| DISEASES 3855 \| KRT7 \| DISEASES 338328 \| GPIHBP1 \| DISEASES 9146 \| HGS \| DISEASES 2520 \| GAST \| DISEASES 222546 \| RFX6 \| DISEASES 9939 \| RBM8A \| DISEASES 23265 \| EXOC7 \| DISEASES 245908 \| DEFB105A \| DISEASES 504180 \| DEFB105B \| DISEASES 885 \| CCK \| DISEASES 226 \| ALDOA \| DISEASES 1908 \| EDN3 \| DISEASES 9376 \| SLC22A8 \| DISEASES 9166 \| EBAG9 \| DISEASES 4089 \| SMAD4 \| DISEASES 1364 \| CLDN4 \| DISEASES 84706 \| GPT2 \| DISEASES 7080 \| NKX2-1 \| DISEASES 100506658 \| OCLN \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 11060 \| WWP2 \| DISEASES 337 \| APOA4 \| DISEASES 26136 \| TES \| DISEASES 4763 \| NF1 \| DISEASES 7037 \| TFRC \| DISEASES 1733 \| DIO1 \| DISEASES 462 \| SERPINC1 \| DISEASES 9095 \| TBX19 \| DISEASES 79626 \| TNFAIP8L2 \| DISEASES 5406 \| PNLIP \| DISEASES 2773 \| GNAI3 \| DISEASES 2805 \| GOT1 \| DISEASES 959 \| CD40LG \| DISEASES 1791 \| DNTT \| DISEASES 1025 \| CDK9 \| DISEASES 7099 \| TLR4 \| DISEASES 51230 \| PHF20 \| DISEASES 1896 \| EDA \| DISEASES 249 \| ALPL \| DISEASES 229 \| ALDOB \| DISEASES 53358 \| SHC3 \| DISEASES 8928 \| FOXH1 \| DISEASES 9356 \| SLC22A6 \| DISEASES 1906 \| EDN1 \| DISEASES 53919 \| SLCO1C1 \| DISEASES 6370 \| CCL25 \| DISEASES 250 \| ALPP \| DISEASES 64423 \| INF2 \| DISEASES 2875 \| GPT \| DISEASES 174 \| AFP \| DISEASES 64223 \| MLST8 \| DISEASES 728441 \| GGT2 \| DISEASES 2641 \| GCG \| DISEASES 50863 \| NTM \| DISEASES 7124 \| TNF \| DISEASES 10165 \| SLC25A13 \| DISEASES 862 \| RUNX1T1 \| DISEASES 4588 \| MUC6 \| DISEASES 3586 \| IL10 \| DISEASES 4583 \| MUC2 \| DISEASES 2859 \| GPR35 \| DISEASES 4585 \| MUC4 \| DISEASES 285782 \| CAGE1 \| DISEASES 151306 \| GPBAR1 \| DISEASES 56 \| ACRV1 \| DISEASES 4586 \| MUC5AC \| DISEASES 4925 \| NUCB2 \| DISEASES 9414 \| TJP2 \| DISEASES 55733 \| HHAT \| DISEASES 136541 \| PRSS58 \| DISEASES 9971 \| NR1H4 \| DISEASES 84525 \| HOPX \| DISEASES 27229 \| TUBGCP4 \| DISEASES 378805 \| LINC-PINT \| DISEASES 26766 \| RNU105C \| DISEASES
Locus	(Waiting for update.)

Disease ID	1283
Disease	obstructive jaundice
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:44) HP:0030731 \| Carcinoma \| 14 HP:0001733 \| Pancreatic inflammation \| 9 HP:0001402 \| Hepatocellular carcinoma \| 9 HP:0030153 \| Cholangiocarcinoma \| 8 HP:0030151 \| Cholangitis \| 8 HP:0002894 \| Neoplasia of the pancreas \| 7 HP:0012531 \| Pain \| 6 HP:0002665 \| Lymphoma \| 4 HP:0002027 \| Abdominal pain \| 4 HP:0002664 \| Neoplasia \| 3 HP:0005206 \| Pancreatic pseudocyst \| 2 HP:0003256 \| Coagulopathy \| 2 HP:0009792 \| Teratoma \| 2 HP:0002586 \| Peritonitis \| 2 HP:0001410 \| Decreased liver function \| 2 HP:0000952 \| Yellow skin \| 2 HP:0002840 \| Lymphadenitis \| 2 HP:0012126 \| Gastric cancer \| 2 HP:0002617 \| Aneurysmal dilatation \| 2 HP:0012191 \| B-cell lymphoma \| 1 HP:0100242 \| Sarcoma \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0030717 \| Meconium peritonitis \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0002018 \| Nausea \| 1 HP:0100762 \| Hemobilia \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0002862 \| Bladder carcinoma \| 1 HP:0001399 \| Liver failure \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0004395 \| Malnutrition \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001824 \| Weight loss \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0000776 \| Diaphragmatic hernia \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0011857 \| Plasmacytoma \| 1 HP:0100890 \| Cyst of the ductus choledochus \| 1 HP:0012570 \| Synovial sarcoma \| 1

Disease ID	1283
Disease	obstructive jaundice
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0009450 \| infection \| 5 C0854776 \| unresectable pancreatic cancer \| 3 C0863194 \| resectable hepatocellular carcinoma \| 2 C1335316 \| serous cystadenoma of the pancreas \| 1 C0018994 \| hemobilia \| 1 C0035078 \| renal failure \| 1 C0021079 \| immunosuppression \| 1 C0162429 \| malnutrition \| 1 C0022660 \| acute renal failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:30)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022354	aminoglutethimide	D000616	125-84-8	jaundice, obstructive	MESH:D041781	marker/mechanism	6691647
C0022354	amitriptyline	D000639	50-48-6	jaundice, obstructive	MESH:D041781	marker/mechanism	11092117
C0022354	busulfan	D002066	55-98-1	jaundice, obstructive	MESH:D041781	marker/mechanism	5278972
C0022354	carbimazole	D002231	22232-54-8	jaundice, obstructive	MESH:D041781	marker/mechanism	3968675
C0022354	chlorpromazine	D002746	50-53-3	jaundice, obstructive	MESH:D041781	marker/mechanism	14961937
C0022354	ciprofloxacin	D002939	85721-33-1	jaundice, obstructive	MESH:D041781	marker/mechanism	12399240
C0022354	clozapine	D003024	5786-21-0	jaundice, obstructive	MESH:D041781	marker/mechanism	2773535
C0022354	disopyramide	D004206	3737/9/5	jaundice, obstructive	MESH:D041781	marker/mechanism	6834895
C0022354	enalapril	D004656	75847-73-3	jaundice, obstructive	MESH:D041781	marker/mechanism	2342045
C0022354	ethambutol	D004977	74-55-5	jaundice, obstructive	MESH:D041781	marker/mechanism	3083914
C0022354	floxuridine	D005467	50-91-9	jaundice, obstructive	MESH:D041781	marker/mechanism	2848277
C0022354	fosinopril	D017328	98048-97-6	jaundice, obstructive	MESH:D041781	marker/mechanism	11293449
C0022354	griseofulvin	D006118	126-07-8	jaundice, obstructive	MESH:D041781	marker/mechanism	131731
C0022354	imipramine	D007099	50-49-7	jaundice, obstructive	MESH:D041781	marker/mechanism	7429116
C0022354	lactulose	D007792	4618-18-2	jaundice, obstructive	MESH:D041781	therapeutic	2311978
C0022354	lovastatin	D008148	75330-75-5	jaundice, obstructive	MESH:D041781	marker/mechanism	2026107
C0022354	medroxyprogesterone acetate	D017258	71-58-9	jaundice, obstructive	MESH:D041781	marker/mechanism	23956101
C0022354	metformin	D008687	657-24-9	jaundice, obstructive	MESH:D041781	marker/mechanism	11467664
C0022354	octreotide	D015282	83150-76-9	jaundice, obstructive	MESH:D041781	marker/mechanism	10923237
C0022354	phenytoin	D010672	57-41-0	jaundice, obstructive	MESH:D041781	marker/mechanism	6721716
C0022354	piroxicam	D010894	36322-90-4	jaundice, obstructive	MESH:D041781	marker/mechanism	1955140
C0022354	propylthiouracil	D011441	51-52-5	jaundice, obstructive	MESH:D041781	marker/mechanism	3528517
C0022354	rifampin	D012293	13292-46-1	jaundice, obstructive	MESH:D041781	marker/mechanism	2488482
C0022354	sulindac	D013467	38194-50-2	jaundice, obstructive	MESH:D041781	marker/mechanism	7083082
C0022354	sulpiride	D013469	15676-16-1	jaundice, obstructive	MESH:D041781	marker/mechanism	3326861
C0022354	tacrolimus	D016559	109581-93-3	jaundice, obstructive	MESH:D041781	marker/mechanism	18648179
C0022354	tenoxicam	C032801	59804-37-4	jaundice, obstructive	MESH:D041781	marker/mechanism	12821054
C0022354	ticlopidine	D013988	55142-85-3	jaundice, obstructive	MESH:D041781	marker/mechanism	1834400
C0022354	trimethoprim	D014295	738-70-5	jaundice, obstructive	MESH:D041781	marker/mechanism	1937651
C0022354	valproic acid	D014635	99-66-1	jaundice, obstructive	MESH:D041781	marker/mechanism	3110488

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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