PedAM
Pediatric Disease Annotations & Medicines
| neutropenia | ||||
| Disease ID | 186 |
|---|---|
| Disease | neutropenia |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:48) C2707258 | infections C2364133 | infection C1963091 | diarrhea C1844383 | recurrent bacterial infections C1719672 | severe sepsis C1609535 | invasive candidiasis C1142423 | staphylococcus aureus bacteremia C1096584 | chlamydia pneumoniae infection C1090821 | sepsis C0752179 | herpes zoster meningoencephalitis C0744471 | gram-negative bacteraemia C0684256 | bacterial septicemia C0520459 | necrotizing enterocolitis C0424755 | fever C0343386 | clostridium difficile infection C0343039 | subcutaneous zygomycosis C0276653 | invasive pulmonary aspergillosis C0272278 | congenital thrombocytopenia C0178829 | genital disorder C0175683 | citrullinemia C0152964 | streptococcal bacteraemia C0151465 | kidney abscess C0149925 | small cell lung cancer C0085394 | serratia infections C0042769 | viral infections C0041296 | tuberculosis C0038395 | streptococcal infections C0036690 | septicemia C0036685 | gram-negative septicemia C0033817 | pseudomonas infection C0032285 | pneumonia C0028992 | omphalitis C0026946 | mycoses C0026946 | fungal infections C0026946 | fungal infection C0025289 | meningitis C0024305 | non-hodgkin's lymphoma C0024291 | hemophagocytic syndrome C0023530 | leukopenia C0023439 | acute eosinophilic leukemia C0015970 | fever of unknown origin C0014733 | erysipelas C0009324 | ulcerative colitis C0006840 | candidiasis C0004623 | bacterial infections C0004623 | bacterial infection C0004610 | bacteremia C0004030 | aspergillosis |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:22) C0021311 | infections | 62 C0015967 | fever | 61 C0009450 | infection | 54 C0036690 | sepsis | 35 C0023530 | leukopenia | 18 C0026946 | fungal infection | 8 C0032285 | pneumonia | 8 C0004623 | bacterial infection | 7 C0004610 | bacteremia | 7 C0004030 | aspergillosis | 6 C1844383 | recurrent bacterial infections | 4 C0011991 | diarrhea | 4 C0024305 | non-hodgkin's lymphoma | 3 C0149925 | small cell lung cancer | 3 C0004623 | bacterial infections | 3 C1719672 | severe sepsis | 3 C0276653 | invasive pulmonary aspergillosis | 3 C0036690 | septicemia | 2 C0006840 | candidiasis | 2 C0024291 | hemophagocytic syndrome | 1 C0026946 | fungal infections | 1 C0025289 | meningitis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:96) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1042522 | 24732641 | 7157 | TP53 | umls:C0023530 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000814326 | 2014 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 24732641 | 4193 | MDM2 | umls:C0023530 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000542884 | 2014 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 21706156 | 4193 | MDM2 | umls:C0023530 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000542884 | 2012 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 21706156 | 4193 | MDM2 | umls:C0027947 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000542884 | 2012 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 21706156 | 7157 | TP53 | umls:C0027947 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000814326 | 2012 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 21706156 | 7157 | TP53 | umls:C0023530 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000814326 | 2012 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 24732641 | 4193 | MDM2 | umls:C0027947 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000542884 | 2014 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 24732641 | 7157 | TP53 | umls:C0027947 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000814326 | 2014 | TP53 | 17 | 7676154 | G | T,C |
| rs1045642 | 19349543 | 54658 | UGT1A1 | umls:C0027947 | BeFree | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia. | 0.14695996 | 2009 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 19349543 | 5243 | ABCB1 | umls:C0027947 | BeFree | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia. | 0.129815515 | 2009 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 19349543 | 5243 | ABCB1 | umls:C0023530 | BeFree | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia. | 0.005895776 | 2009 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 21327421 | 5243 | ABCB1 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.005895776 | 2011 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 21327421 | 1558 | CYP2C8 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 21327421 | 5243 | ABCB1 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.129815515 | 2011 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 25007187 | 5243 | ABCB1 | umls:C0023530 | BeFree | In addition, a statistically significant association was found among neutropenia (absolute neutrophil count<500) and variant allele carriers of ABCB1 rs1045642 (OR=5.174; 95% CI: 1.674; 15.989) and ABCB1 rs1128503 (OR=3.364; 95% CI: 1.257; 9.004), respectively. | 0.005895776 | 2014 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 21327421 | 1558 | CYP2C8 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 21706123 | 5243 | ABCB1 | umls:C0023530 | BeFree | Serum LDH may be a promising predictor of prognosis, and the ABCB1 C3435T polymorphism may be a genetic predictor of the severity of leukocytopenia in patients with CRPC treated with DEC. | 0.005895776 | 2012 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 25007187 | 5243 | ABCB1 | umls:C0027947 | BeFree | In addition, a statistically significant association was found among neutropenia (absolute neutrophil count<500) and variant allele carriers of ABCB1 rs1045642 (OR=5.174; 95% CI: 1.674; 15.989) and ABCB1 rs1128503 (OR=3.364; 95% CI: 1.257; 9.004), respectively. | 0.129815515 | 2014 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1045642 | 19349543 | 54658 | UGT1A1 | umls:C0023530 | BeFree | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia. | 0.01302921 | 2009 | ABCB1 | 7 | 87509329 | A | T,G |
| rs11045585 | 18294295 | 1244 | ABCC2 | umls:C0027947 | BeFree | The combined analysis indicated a significant association of rs12762549 in ABCC2 (P = 0.00022) and rs11045585 in SLCO1B3 (P = 0.00017) with docetaxel-induced leukopenia/neutropenia. | 0.008544182 | 2008 | SLCO1B3 | 12 | 20892760 | A | G |
| rs11141915 | 22293537 | 1612 | DAPK1 | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | DAPK1 | 9 | 87620879 | A | C |
| rs11141915 | 22293537 | 1612 | DAPK1 | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | DAPK1 | 9 | 87620879 | A | C |
| rs11141915 | 22293537 | 5142 | PDE4B | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | DAPK1 | 9 | 87620879 | A | C |
| rs11141915 | 22293537 | 5142 | PDE4B | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | DAPK1 | 9 | 87620879 | A | C |
| rs1128503 | 25007187 | 5243 | ABCB1 | umls:C0023530 | BeFree | In addition, a statistically significant association was found among neutropenia (absolute neutrophil count<500) and variant allele carriers of ABCB1 rs1045642 (OR=5.174; 95% CI: 1.674; 15.989) and ABCB1 rs1128503 (OR=3.364; 95% CI: 1.257; 9.004), respectively. | 0.005895776 | 2014 | ABCB1 | 7 | 87550285 | A | G |
| rs1128503 | 21327421 | 5243 | ABCB1 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.129815515 | 2011 | ABCB1 | 7 | 87550285 | A | G |
| rs1128503 | 21327421 | 5243 | ABCB1 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.005895776 | 2011 | ABCB1 | 7 | 87550285 | A | G |
| rs1128503 | 21327421 | 1558 | CYP2C8 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87550285 | A | G |
| rs1128503 | 25007187 | 5243 | ABCB1 | umls:C0027947 | BeFree | In addition, a statistically significant association was found among neutropenia (absolute neutrophil count<500) and variant allele carriers of ABCB1 rs1045642 (OR=5.174; 95% CI: 1.674; 15.989) and ABCB1 rs1128503 (OR=3.364; 95% CI: 1.257; 9.004), respectively. | 0.129815515 | 2014 | ABCB1 | 7 | 87550285 | A | G |
| rs1128503 | 21327421 | 1558 | CYP2C8 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87550285 | A | G |
| rs11540654 | 21706156 | 4193 | MDM2 | umls:C0023530 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000542884 | 2012 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11540654 | 21706156 | 4193 | MDM2 | umls:C0027947 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000542884 | 2012 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11540654 | 21706156 | 7157 | TP53 | umls:C0023530 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000814326 | 2012 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11540654 | 21706156 | 7157 | TP53 | umls:C0027947 | BeFree | MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively, in breast cancer patients treated with FEC100, and especially their combination may be a useful predictor of severe neutropenia and FN. | 0.000814326 | 2012 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11706052 | 20061166 | 3615 | IMPDH2 | umls:C0027947 | BeFree | The IMPDH2 rs11706052 G variant was associated with more frequent neutropenia requiring dose-holding (p = 0.046). | 0.000271442 | 2010 | IMPDH2 | 3 | 49026677 | A | G |
| rs11706052 | 20061166 | 3615 | IMPDH2 | umls:C0023530 | BeFree | The IMPDH2 rs11706052 G variant was associated with more frequent neutropenia requiring dose-holding (p = 0.046). | 0.000271442 | 2010 | IMPDH2 | 3 | 49026677 | A | G |
| rs11719165 | 22293537 | 5142 | PDE4B | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 3 | 194865359 | T | C |
| rs11719165 | 22293537 | 1612 | DAPK1 | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 3 | 194865359 | T | C |
| rs11719165 | 22293537 | 5142 | PDE4B | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 3 | 194865359 | T | C |
| rs11719165 | 22293537 | 1612 | DAPK1 | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 3 | 194865359 | T | C |
| rs12046844 | 22293537 | 1612 | DAPK1 | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 1 | 65772696 | G | A |
| rs12046844 | 22293537 | 5142 | PDE4B | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 1 | 65772696 | G | A |
| rs12046844 | 22293537 | 5142 | PDE4B | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 1 | 65772696 | G | A |
| rs12046844 | 22293537 | 1612 | DAPK1 | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 1 | 65772696 | G | A |
| rs12762549 | 18294295 | 1244 | ABCC2 | umls:C0027947 | BeFree | The combined analysis indicated a significant association of rs12762549 in ABCC2 (P = 0.00022) and rs11045585 in SLCO1B3 (P = 0.00017) with docetaxel-induced leukopenia/neutropenia. | 0.008544182 | 2008 | NA | 10 | 99861014 | C | G |
| rs1695 | 23812950 | 2950 | GSTP1 | umls:C0023530 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.002909916 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 23812950 | 2944 | GSTM1 | umls:C0023530 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.000814326 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 23812950 | 2950 | GSTP1 | umls:C0027947 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.002909916 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 23812950 | 2952 | GSTT1 | umls:C0023530 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.000814326 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 23812950 | 2952 | GSTT1 | umls:C0027947 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.002909916 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 23812950 | 2944 | GSTM1 | umls:C0027947 | BeFree | On evaluating higher order gene-gene interaction models by MDR analysis, GSTM1 and GSTP1 Ile105Val; GSTM1 and GSTT1; and GSTT1 and GSTP1 Ile105Val showed significant association with treatment response, grade 2-4 anemia, and dose delay/reduction due to neutropenia (P=0.046, P=0.027, P=0.026), respectively. | 0.003181358 | 2014 | GSTP1 | 11 | 67585218 | A | G |
| rs1901440 | 22293537 | 1612 | DAPK1 | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 2 | 133680388 | C | A |
| rs1901440 | 22293537 | 5142 | PDE4B | umls:C0023530 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 2 | 133680388 | C | A |
| rs1901440 | 22293537 | 5142 | PDE4B | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 2 | 133680388 | C | A |
| rs1901440 | 22293537 | 1612 | DAPK1 | umls:C0027947 | BeFree | We identified four loci possibly associated with gemcitabine-induced leukopenia/neutropenia [rs11141915 in DAPK1 on chromosome 9q21, combined P=1.27×10, odds ratio (OR)=4.10; rs1901440 on chromosome 2q12, combined P=3.11×10, OR=34.00; rs12046844 in PDE4B on chromosome 1p31, combined P=4.56×10, OR=4.13; rs11719165 on chromosome 3q29, combined P=5.98×10, OR=2.60]. | 0.000271442 | 2012 | NA | 2 | 133680388 | C | A |
| rs2032582 | 21327421 | 1558 | CYP2C8 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87531302 | A | T,C |
| rs2032582 | 21327421 | 5243 | ABCB1 | umls:C0023530 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.005895776 | 2011 | ABCB1 | 7 | 87531302 | A | T,C |
| rs2032582 | 21327421 | 1558 | CYP2C8 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.000271442 | 2011 | ABCB1 | 7 | 87531302 | A | T,C |
| rs2032582 | 21327421 | 5243 | ABCB1 | umls:C0027947 | BeFree | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correlated to overall survival, sensoric neuropathy, and neutropenia in 119 patients treated for ovarian cancer with paclitaxel/carboplatin. | 0.129815515 | 2011 | ABCB1 | 7 | 87531302 | A | T,C |
| rs2244613 | 25611302 | 1244 | ABCC2 | umls:C0027947 | BeFree | Reduced risk of neutropenia and diarrhoea was associated with ABCC2-24C/T (odds ratio (OR)=0.22, 0.06-0.85) and CES1 (rs2244613; OR=0.29, 0.09-0.89), respectively. | 0.008544182 | 2014 | CES1 | 16 | 55810697 | G | T |
| rs2244613 | 25611302 | 1244 | ABCC2 | umls:C0023530 | BeFree | Reduced risk of neutropenia and diarrhoea was associated with ABCC2-24C/T (odds ratio (OR)=0.22, 0.06-0.85) and CES1 (rs2244613; OR=0.29, 0.09-0.89), respectively. | 0.003724241 | 2014 | CES1 | 16 | 55810697 | G | T |
| rs2244613 | 25611302 | 1066 | CES1 | umls:C0023530 | BeFree | Reduced risk of neutropenia and diarrhoea was associated with ABCC2-24C/T (odds ratio (OR)=0.22, 0.06-0.85) and CES1 (rs2244613; OR=0.29, 0.09-0.89), respectively. | 0.000271442 | 2014 | CES1 | 16 | 55810697 | G | T |
| rs2244613 | 25611302 | 1066 | CES1 | umls:C0027947 | BeFree | Reduced risk of neutropenia and diarrhoea was associated with ABCC2-24C/T (odds ratio (OR)=0.22, 0.06-0.85) and CES1 (rs2244613; OR=0.29, 0.09-0.89), respectively. | 0.000271442 | 2014 | CES1 | 16 | 55810697 | G | T |
| rs2279744 | 24732641 | 4193 | MDM2 | umls:C0023530 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000542884 | 2014 | MDM2 | 12 | 68808800 | T | G |
| rs2279744 | 24732641 | 7157 | TP53 | umls:C0027947 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000814326 | 2014 | MDM2 | 12 | 68808800 | T | G |
| rs2279744 | 24732641 | 4193 | MDM2 | umls:C0027947 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000542884 | 2014 | MDM2 | 12 | 68808800 | T | G |
| rs2279744 | 24732641 | 7157 | TP53 | umls:C0023530 | BeFree | MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. | 0.000814326 | 2014 | MDM2 | 12 | 68808800 | T | G |
| rs2305482 | 25515861 | 3447 | IFNA13 | umls:C0023530 | BeFree | Logistic regression analysis showed that rs2305482 CC and neutrophil count at baseline were independent predictive factors for IFN-induced neutropenia (OR = 2.497, P = 0.0072 and OR = 0.998, P < 0.0001, respectively). | 0.000542884 | 2014 | PSMD3 | 17 | 39984674 | A | C |
| rs2305482 | 25515861 | 3447 | IFNA13 | umls:C0027947 | BeFree | Logistic regression analysis showed that rs2305482 CC and neutrophil count at baseline were independent predictive factors for IFN-induced neutropenia (OR = 2.497, P = 0.0072 and OR = 0.998, P < 0.0001, respectively). | 0.000542884 | 2014 | PSMD3 | 17 | 39984674 | A | C |
| rs2916733 | 21799462 | 79648 | MCPH1 | umls:C0027947 | BeFree | The combined analysis indicated that rs2916733 in microcephalin 1 [combined PFisher min=2.27×10, odds ratio (OR)=2.74 with 95% confidence interval (CI)=1.96-3.83; the nonrisk genotype as reference] was significantly associated with epirubicin-induced leukopenia/neutropenia. | 0.000271442 | 2011 | MCPH1 | 8 | 6465757 | G | A |
| rs2916733 | 21799462 | 79648 | MCPH1 | umls:C0023530 | BeFree | The combined analysis indicated that rs2916733 in microcephalin 1 [combined PFisher min=2.27×10, odds ratio (OR)=2.74 with 95% confidence interval (CI)=1.96-3.83; the nonrisk genotype as reference] was significantly associated with epirubicin-induced leukopenia/neutropenia. | 0.000271442 | 2011 | MCPH1 | 8 | 6465757 | G | A |
| rs3087403 | 24956248 | 51455 | REV1 | umls:C0027947 | BeFree | Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively). | 0.000271442 | 2015 | REV1 | 2 | 99442408 | C | T |
| rs3087403 | 24956248 | 51455 | REV1 | umls:C0023530 | BeFree | Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively). | 0.000271442 | 2015 | REV1 | 2 | 99442408 | C | T |
| rs3087403 | 24956248 | 81890 | QTRT1 | umls:C0027947 | BeFree | Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively). | 0.000271442 | 2015 | REV1 | 2 | 99442408 | C | T |
| rs3087403 | 24956248 | 81890 | QTRT1 | umls:C0023530 | BeFree | Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively). | 0.000271442 | 2015 | REV1 | 2 | 99442408 | C | T |
| rs3136228 | 22868256 | 2956 | MSH6 | umls:C0023530 | BeFree | hMSH6-rs3136228 was associated with grade 3-4 neutropenia (3.23(1.38-7.57), q-value=0.0937). | 0.000271442 | 2012 | MSH6 | 2 | 47782677 | T | G |
| rs3136228 | 22868256 | 2956 | MSH6 | umls:C0027947 | BeFree | hMSH6-rs3136228 was associated with grade 3-4 neutropenia (3.23(1.38-7.57), q-value=0.0937). | 0.000271442 | 2012 | MSH6 | 2 | 47782677 | T | G |
| rs386467430 | 25381393 | 1806 | DPYD | umls:C0023530 | BeFree | The DPYD*2A variant statistically significantly associated with the specific AEs nausea/vomiting (P = .007) and neutropenia (P < .001), whereas D949V statistically significantly associated with dehydration (P = .02), diarrhea (P = .003), leukopenia (P = .002), neutropenia (P < .001), and thrombocytopenia (P < .001). | 0.003452799 | 2015 | NA | NA | NA | NA | NA |
| rs386467430 | 25381393 | 1806 | DPYD | umls:C0027947 | BeFree | The DPYD*2A variant statistically significantly associated with the specific AEs nausea/vomiting (P = .007) and neutropenia (P < .001), whereas D949V statistically significantly associated with dehydration (P = .02), diarrhea (P = .003), leukopenia (P = .002), neutropenia (P < .001), and thrombocytopenia (P < .001). | 0.120814326 | 2015 | NA | NA | NA | NA | NA |
| rs387906717 | 19006568 | 7454 | WAS | umls:C0023530 | BeFree | A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. | 0.001357209 | 2009 | WAS | X | 48688403 | T | C |
| rs387906717 | 19006568 | 7454 | WAS | umls:C0027947 | BeFree | A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. | 0.00408156 | 2009 | WAS | X | 48688403 | T | C |
| rs4969170 | 23133602 | 9021 | SOCS3 | umls:C0027947 | BeFree | HCV treatment-induced neutropenia and thrombocytopenia are associated with SOCS3 rs4969170 polymorphism. | 0.000271442 | 2012 | LOC101928674 | 17 | 78364457 | A | G |
| rs4969170 | 23133602 | 9021 | SOCS3 | umls:C0023530 | BeFree | HCV treatment-induced neutropenia and thrombocytopenia are associated with SOCS3 rs4969170 polymorphism. | 0.000271442 | 2012 | LOC101928674 | 17 | 78364457 | A | G |
| rs67376798 | 25381393 | 1806 | DPYD | umls:C0027947 | BeFree | The DPYD*2A variant statistically significantly associated with the specific AEs nausea/vomiting (P = .007) and neutropenia (P < .001), whereas D949V statistically significantly associated with dehydration (P = .02), diarrhea (P = .003), leukopenia (P = .002), neutropenia (P < .001), and thrombocytopenia (P < .001). | 0.120814326 | 2015 | DPYD | 1 | 97082391 | T | A |
| rs67376798 | 25381393 | 1806 | DPYD | umls:C0023530 | BeFree | The DPYD*2A variant statistically significantly associated with the specific AEs nausea/vomiting (P = .007) and neutropenia (P < .001), whereas D949V statistically significantly associated with dehydration (P = .02), diarrhea (P = .003), leukopenia (P = .002), neutropenia (P < .001), and thrombocytopenia (P < .001). | 0.003452799 | 2015 | DPYD | 1 | 97082391 | T | A |
| rs6838440 | 21799462 | 80216 | ALPK1 | umls:C0023530 | GAD | [Our findings show that genetic variants in the microcephalin 1 locus are suggestively associated with the risk of epirubicin-induced ADRs and might be applicable in development of diagnostic system for predicting the risk of the ADRs, leading to better pr] | 0.002367032 | 2011 | ALPK1 | 4 | 112406922 | C | T |
| rs693955 | 25735499 | 1635 | DCTD | umls:C0027947 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | SLC29A1 | 6 | 44224183 | A | C |
| rs693955 | 25735499 | 2030 | SLC29A1 | umls:C0027947 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | SLC29A1 | 6 | 44224183 | A | C |
| rs693955 | 25735499 | 1635 | DCTD | umls:C0023530 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | SLC29A1 | 6 | 44224183 | A | C |
| rs693955 | 25735499 | 2030 | SLC29A1 | umls:C0023530 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | SLC29A1 | 6 | 44224183 | A | C |
| rs9561778 | 19696793 | 231 | AKR1B1 | umls:C0027947 | BeFree | Subgroup analysis also indicated that the SNP rs9561778 was significantly associated with two major ADR subgroups; gastrointestinal toxicity and leukopenia/neutropenia (Cochran-Armitage trend's P-value=0.00019 and 0.014; OR=2.31 and 1.83). | 0.000271442 | 2009 | ABCC4 | 13 | 95061461 | G | A,T |
| rs9561778 | 19696793 | 231 | AKR1B1 | umls:C0023530 | BeFree | Subgroup analysis also indicated that the SNP rs9561778 was significantly associated with two major ADR subgroups; gastrointestinal toxicity and leukopenia/neutropenia (Cochran-Armitage trend's P-value=0.00019 and 0.014; OR=2.31 and 1.83). | 0.000271442 | 2009 | ABCC4 | 13 | 95061461 | G | A,T |
| rs9990999 | 25735499 | 1635 | DCTD | umls:C0027947 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | DCTD | 4 | 182902820 | G | A |
| rs9990999 | 25735499 | 2030 | SLC29A1 | umls:C0023530 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | DCTD | 4 | 182902820 | G | A |
| rs9990999 | 25735499 | 1635 | DCTD | umls:C0023530 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | DCTD | 4 | 182902820 | G | A |
| rs9990999 | 25735499 | 2030 | SLC29A1 | umls:C0027947 | BeFree | The DCTD rs9990999 AG/GG and SLC29A1 rs693955 CC genotypes were also significantly associated with shorter duration of neutropenia. | 0.000271442 | 2015 | DCTD | 4 | 182902820 | G | A |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:1609) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 1 | 1138913 | rs3819001 | T | C | rs3819001 | 23648065 | 5.45E-05 | Allelic model | 2.78 | [1.70-4.53] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3819001-C | Research Support, Non-U.S. Gov't |
| 1 | 2068906 | rs3128296 | G | T | rs3128296 | 23648065 | 2.45E-05 | Dominant model | 10.94 | [2.55-46.90] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3128296-G | Research Support, Non-U.S. Gov't |
| 1 | 2281726 | rs7527871 | A | C | rs7527871 | 23648065 | 8.70E-05 | Recessive model | 1.37 | [1.15-1.64] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7527871-A | Research Support, Non-U.S. Gov't |
| 1 | 5142784 | rs12047111 | A | G | rs12047111 | 23648065 | 6.69E-05 | Allelic model | 2.37 | [1.53-3.69] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12047111-G | Research Support, Non-U.S. Gov't |
| 1 | 5142818 | rs2334263 | T | C | rs2334263 | 23648065 | 4.87E-05 | Dominant model | 2.06 | [1.36-3.12] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2334263-G | Research Support, Non-U.S. Gov't |
| 1 | 5689702 | rs770683 | A | G | rs770683 | 23648065 | 7.54E-05 | Dominant model | 2.25 | [1.48-3.43] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs770683-T | Research Support, Non-U.S. Gov't |
| 1 | 9533238 | rs6679380 | C | T | rs6679380 | 23648065 | 8.33E-05 | Allelic model | 2.58 | [1.60-4.15] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6679380-G | Research Support, Non-U.S. Gov't |
| 1 | 15339960 | rs6429703 | T | C | rs6429703 | 23648065 | 8.00E-06 | Allelic model | 2.94 | [1.80-4.80] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6429703-T | Research Support, Non-U.S. Gov't |
| 1 | 20061456 | rs3850533 | T | C | rs3850533 | 23648065 | 2.40E-05 | Dominant model | 2.69 | [1.34-5.40] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3850533-C | Research Support, Non-U.S. Gov't |
| 1 | 20279405 | rs818968 | C | T | rs818968 | 23648065 | 4.76E-05 | Allelic model | 2.38 | [1.51-3.75] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs818968-G | Research Support, Non-U.S. Gov't |
| 1 | 21826566 | rs6667242 | A | G | rs6667242 | 23648065 | 1.11E-05 | Dominant model | 1.42 | [1.19-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6667242-A | Research Support, Non-U.S. Gov't |
| 1 | 21837755 | rs16825455 | A | G | rs16825455 | 23648065 | 9.00E-06 | Dominant model | 1.43 | [1.19-1.70] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16825455-T | Research Support, Non-U.S. Gov't |
| 1 | 22493672 | rs2807356 | T | C | rs2807356 | 23648065 | 3.59E-05 | Allelic model | 3.68 | [2.04-6.67] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2807356-T | Research Support, Non-U.S. Gov't |
| 1 | 30278550 | rs10914475 | C | T | rs10914475 | 23648065 | 4.98E-05 | Dominant model | 6.79 | [2.28-20.25] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10914475-A | Research Support, Non-U.S. Gov't |
| 1 | 30660403 | rs7523165 | A | G | rs7523165 | 23648065 | 7.83E-05 | Allelic model | 1.81 | [1.36-2.42] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7523165-G | Research Support, Non-U.S. Gov't |
| 1 | 30660839 | rs12072928 | T | G | rs12072928 | 23648065 | 3.99E-05 | Allelic model | 1.93 | [1.42-2.63] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12072928-G | Research Support, Non-U.S. Gov't |
| 1 | 30663554 | rs10915040 | A | G | rs10915040 | 23648065 | 4.71E-05 | Allelic model | 1.9 | [1.40-2.59] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10915040-G | Research Support, Non-U.S. Gov't |
| 1 | 31022237 | rs904257 | A | G | rs904257 | 23648065 | 2.71E-05 | Recessive model | 1.58 | [1.13-2.22] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs904257-G | Research Support, Non-U.S. Gov't |
| 1 | 31034663 | rs3104425 | C | T | rs3104425 | 23648065 | 2.71E-05 | Recessive model | 1.58 | [1.13-2.22] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3104425-A | Research Support, Non-U.S. Gov't |
| 1 | 34418942 | rs504471 | A | G | rs504471 | 23648065 | 2.93E-05 | Dominant model | 2.06 | [1.45-2.93] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs504471-G | Research Support, Non-U.S. Gov't |
| 1 | 37900173 | rs10796907 | A | G | rs10796907 | pha003095 | 6.75E-06 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10796907-A | NA |
| 1 | 38117562 | rs4653314 | T | C | rs4653314 | 23648065 | 1.31E-05 | Allelic model | 2.88 | [1.79-4.62] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4653314-T | Research Support, Non-U.S. Gov't |
| 1 | 38117562 | rs573381957 | TC | T | rs4653314 | 23648065 | 1.31E-05 | Allelic model | 2.88 | [1.79-4.62] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4653314-T | Research Support, Non-U.S. Gov't |
| 1 | 41053260 | rs6677621 | C | T | rs6677621 | 23648065 | 9.68E-05 | Dominant model | 1.73 | [1.25-2.40] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6677621-A | Research Support, Non-U.S. Gov't |
| 1 | 42738366 | rs12402117 | G | A | rs12402117 | 23648065 | 2.71E-05 | Dominant model | 2.26 | [1.45-3.54] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12402117-C | Research Support, Non-U.S. Gov't |
| 1 | 42738366 | rs12402117 | G | A | rs12402117 | 23648065 | 2.98E-05 | Dominant model | 4.21 | [1.82-9.78] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12402117-C | Research Support, Non-U.S. Gov't |
| 1 | 44972309 | rs781775 | G | A | rs781775 | 23648065 | 3.82E-05 | Allelic model | 1.74 | [1.34-2.26] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs781775-A | Research Support, Non-U.S. Gov't |
| 1 | 44974119 | rs781770 | C | T | rs781770 | 23648065 | 2.71E-05 | Allelic model | 1.77 | [1.36-2.29] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs781770-T | Research Support, Non-U.S. Gov't |
| 1 | 44976806 | rs781790 | A | G | rs781790 | 23648065 | 2.85E-05 | Allelic model | 1.75 | [1.35-2.27] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs781790-C | Research Support, Non-U.S. Gov't |
| 1 | 46503217 | rs1768808 | C | T | rs1768808 | 23648065 | 1.18E-05 | Recessive model | 1.44 | [1.13-1.84] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1768808-T | Research Support, Non-U.S. Gov't |
| 1 | 48098406 | rs2506991 | A | G | rs2506991 | 23648065 | 2.00E-06 | Recessive model | 3.95 | [2.10-7.42] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2506991-G | Research Support, Non-U.S. Gov't |
| 1 | 48100829 | rs2506987 | A | G | rs2506987 | 23648065 | 3.94E-05 | Recessive model | 3.35 | [1.80-6.22] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2506987-C | Research Support, Non-U.S. Gov't |
| 1 | 48965583 | rs12032082 | C | T | rs12032082 | 23648065 | 6.64E-05 | Dominant model | 2.69 | [1.54-4.69] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12032082-T | Research Support, Non-U.S. Gov't |
| 1 | 49664304 | rs11591141 | C | T | rs11591141 | 23648065 | 2.26E-05 | Recessive model | 1.5 | [1.12-2.00] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11591141-G | Research Support, Non-U.S. Gov't |
| 1 | 49762418 | rs1431638 | C | T | rs1431638 | 23648065 | 2.26E-05 | Recessive model | 1.51 | [1.13-2.02] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1431638-G | Research Support, Non-U.S. Gov't |
| 1 | 49949006 | rs1933271 | C | T | rs1933271 | 23648065 | 2.26E-05 | Recessive model | 1.56 | [1.17-2.10] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1933271-C | Research Support, Non-U.S. Gov't |
| 1 | 50128198 | rs4408195 | G | A | rs4408195 | 23648065 | 2.26E-05 | Recessive model | 1.54 | [1.15-2.06] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4408195-C | Research Support, Non-U.S. Gov't |
| 1 | 52293570 | rs2077725 | G | A | rs2077725 | 23648065 | 8.92E-05 | Allelic model | 2.16 | [1.45-3.23] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2077725-A | Research Support, Non-U.S. Gov't |
| 1 | 52316785 | rs6676789 | T | C | rs6676789 | 23648065 | 8.92E-05 | Allelic model | 2.16 | [1.45-3.23] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6676789-G | Research Support, Non-U.S. Gov't |
| 1 | 52343297 | rs6663305 | A | G | rs6663305 | 23648065 | 8.98E-05 | Allelic model | 2.15 | [1.44-3.22] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6663305-A | Research Support, Non-U.S. Gov't |
| 1 | 56056400 | rs4926690 | G | A | rs4926690 | pha003095 | 8.54E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4926690-G | NA |
| 1 | 56429031 | rs2192102 | C | A | rs2192102 | 23648065 | 4.66E-05 | Recessive model | 1.53 | [1.11-2.09] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2192102-A | Research Support, Non-U.S. Gov't |
| 1 | 56432184 | rs12409063 | G | A | rs12409063 | 23648065 | 4.66E-05 | Recessive model | 1.53 | [1.11-2.09] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12409063-A | Research Support, Non-U.S. Gov't |
| 1 | 56798308 | rs2994565 | A | G | rs2994565 | 23648065 | 2.25E-05 | Recessive model | 1.44 | [1.04-1.99] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2994565-A | Research Support, Non-U.S. Gov't |
| 1 | 58857598 | rs849492 | C | A | rs849492 | 23648065 | 9.44E-05 | Recessive model | 1.33 | [1.09-1.63] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs849492-G | Research Support, Non-U.S. Gov't |
| 1 | 58857666 | rs338934 | A | G | rs338934 | 23648065 | 3.32E-05 | Recessive model | 1.35 | [1.10-1.65] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs338934-T | Research Support, Non-U.S. Gov't |
| 1 | 60084516 | rs12727131 | G | A | rs12727131 | 21507922 | 3.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 1 | 66238379 | rs12046844 | G | A | rs12046844 | 23648065 | 5.84E-04 | Dominant model | 2.53 | [1.45-4.43] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12046844-C | Research Support, Non-U.S. Gov't |
| 1 | 68604773 | rs1864570 | G | A | rs1864570 | 23648065 | 7.32E-05 | Dominant model | 3.49 | [1.61-7.55] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1864570-A | Research Support, Non-U.S. Gov't |
| 1 | 68633924 | rs1367448 | G | A | rs1367448 | 23648065 | 5.00E-06 | Dominant model | 1.55 | [1.21-1.99] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1367448-C | Research Support, Non-U.S. Gov't |
| 1 | 69975660 | rs10889833 | G | A | rs10889833 | 23648065 | 2.54E-05 | Allelic model | 2.15 | [1.50-3.08] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10889833-C | Research Support, Non-U.S. Gov't |
| 1 | 70029922 | rs4650295 | C | T | rs4650295 | pha003095 | 7.95E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4650295-C | NA |
| 1 | 79110518 | rs4650590 | A | G | rs4650590 | 23648065 | 5.21E-05 | Dominant model | 1.58 | [1.19-2.09] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4650590-C | Research Support, Non-U.S. Gov't |
| 1 | 81996353 | rs17454592 | G | A | rs17454592 | 23648065 | 5.60E-05 | Dominant model | 3.81 | [1.78-8.13] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17454592-C | Research Support, Non-U.S. Gov't |
| 1 | 82848122 | rs11163467 | C | T | rs11163467 | 23648065 | 5.77E-05 | Recessive model | 1.35 | [1.06-1.71] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11163467-A | Research Support, Non-U.S. Gov't |
| 1 | 83171994 | rs10493722 | C | T | rs10493722 | 23648065 | 7.46E-05 | Allelic model | 4.32 | [2.10-8.87] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10493722-T | Research Support, Non-U.S. Gov't |
| 1 | 83204106 | rs2060361 | C | T | rs2060361 | 23648065 | 7.46E-05 | Allelic model | 4.32 | [2.10-8.87] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2060361-A | Research Support, Non-U.S. Gov't |
| 1 | 85400114 | rs1325277 | C | A | rs1325277 | 23648065 | 5.63E-05 | Recessive model | 1.23 | [1.02-1.49] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1325277-G | Research Support, Non-U.S. Gov't |
| 1 | 86008398 | rs17099679 | A | G | rs17099679 | 23648065 | 6.63E-05 | Allelic model | 2.31 | [1.51-3.52] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17099679-A | Research Support, Non-U.S. Gov't |
| 1 | 86008536 | rs12734233 | G | A | rs12734233 | 23648065 | 6.63E-05 | Allelic model | 2.31 | [1.51-3.52] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12734233-G | Research Support, Non-U.S. Gov't |
| 1 | 88083782 | rs923545 | G | A | rs923545 | 23648065 | 4.11E-05 | Allelic model | 2 | [1.44-2.77] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs923545-T | Research Support, Non-U.S. Gov't |
| 1 | 88287371 | rs2491281 | C | T | rs2491281 | 23648065 | 8.45E-05 | Dominant model | 1.62 | [1.27-2.06] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2491281-T | Research Support, Non-U.S. Gov't |
| 1 | 89016499 | rs10493815 | G | A | rs10493815 | pha003095 | 4.77E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10493815-A | NA |
| 1 | 90005132 | rs9428043 | T | C | rs9428043 | 23648065 | 4.26E-05 | Recessive model | 1.79 | [1.24-2.59] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9428043-G | Research Support, Non-U.S. Gov't |
| 1 | 90005132 | rs9428043 | T | C | rs9428043 | 23648065 | 9.25E-05 | Recessive model | 1.51 | [1.15-1.98] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9428043-G | Research Support, Non-U.S. Gov't |
| 1 | 90022796 | rs922107 | A | G | rs922107 | 23648065 | 3.00E-06 | Recessive model | 1.79 | [1.25-2.56] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs922107-G | Research Support, Non-U.S. Gov't |
| 1 | 90023768 | rs6699344 | G | A | rs6699344 | 23648065 | 2.02E-05 | Recessive model | 1.34 | [1.01-1.77] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6699344-A | Research Support, Non-U.S. Gov't |
| 1 | 90023768 | rs6699344 | G | A | rs6699344 | 23648065 | 2.73E-06 | Recessive model | 1.83 | [1.26-2.64] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6699344-A | Research Support, Non-U.S. Gov't |
| 1 | 90023768 | rs6699344 | G | A | rs6699344 | 23648065 | 4.13E-06 | Recessive model | 1.58 | [1.20-2.06] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6699344-A | Research Support, Non-U.S. Gov't |
| 1 | 90025519 | rs922106 | C | A | rs922106 | 23648065 | 9.00E-07 | Recessive model | 1.68 | [1.28-2.21] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs922106-T | Research Support, Non-U.S. Gov't |
| 1 | 90032940 | rs10922664 | A | G | rs10922664 | 23648065 | 3.70E-05 | Recessive model | 1.39 | [1.04-1.84] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10922664-G | Research Support, Non-U.S. Gov't |
| 1 | 90032940 | rs10922664 | A | G | rs10922664 | 23648065 | 5.80E-06 | Recessive model | 1.87 | [1.28-2.71] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10922664-G | Research Support, Non-U.S. Gov't |
| 1 | 90032940 | rs10922664 | A | G | rs10922664 | 23648065 | 9.28E-07 | Recessive model | 1.68 | [1.28-2.21] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10922664-G | Research Support, Non-U.S. Gov't |
| 1 | 90050831 | rs7516314 | A | G | rs7516314 | 23648065 | 3.70E-05 | Recessive model | 1.37 | [1.03-1.82] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7516314-C | Research Support, Non-U.S. Gov't |
| 1 | 90050831 | rs7516314 | A | G | rs7516314 | 23648065 | 3.77E-06 | Recessive model | 1.66 | [1.26-2.17] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7516314-C | Research Support, Non-U.S. Gov't |
| 1 | 90050831 | rs7516314 | A | G | rs7516314 | 23648065 | 5.80E-06 | Recessive model | 1.87 | [1.29-2.72] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7516314-C | Research Support, Non-U.S. Gov't |
| 1 | 90053245 | rs12135419 | C | T | rs12135419 | 23648065 | 3.70E-05 | Recessive model | 1.37 | [1.03-1.82] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12135419-T | Research Support, Non-U.S. Gov't |
| 1 | 90053245 | rs12135419 | C | T | rs12135419 | 23648065 | 3.77E-06 | Recessive model | 1.66 | [1.26-2.17] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12135419-T | Research Support, Non-U.S. Gov't |
| 1 | 90053245 | rs12135419 | C | T | rs12135419 | 23648065 | 5.80E-06 | Recessive model | 1.87 | [1.29-2.72] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12135419-T | Research Support, Non-U.S. Gov't |
| 1 | 97992257 | rs2811173 | C | T | rs2811173 | 23648065 | 9.01E-05 | Dominant model | 2.95 | [1.59-5.49] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2811173-G | Research Support, Non-U.S. Gov't |
| 1 | 99184798 | rs12725220 | G | A | rs12725220 | 23648065 | 3.08E-05 | Allelic model | 1.72 | [1.33-2.22] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12725220-C | Research Support, Non-U.S. Gov't |
| 1 | 99515902 | rs7530449 | T | G | rs7530449 | 23648065 | 7.66E-05 | Dominant model | 2.23 | [1.44-3.48] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7530449-G | Research Support, Non-U.S. Gov't |
| 1 | 99533944 | rs17119481 | A | C | rs17119481 | 23648065 | 7.66E-05 | Dominant model | 2.18 | [1.40-3.38] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17119481-C | Research Support, Non-U.S. Gov't |
| 1 | 99589379 | rs303386 | C | T | rs303386 | 23648065 | 4.00E-06 | Dominant | 1.77 | [1.26-2.48] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs303386-A | Research Support, Non-U.S. Gov't |
| 1 | 99589379 | rs303386 | C | T | rs303386 | 23648065 | 4.00E-06 | Dominant model | 2.24 | [1.45-3.46] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs303386-A | Research Support, Non-U.S. Gov't |
| 1 | 105688179 | rs11184448 | A | G | rs11184448 | 23648065 | 7.78E-05 | Dominant model | 1.4 | [1.15-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11184448-A | Research Support, Non-U.S. Gov't |
| 1 | 105688537 | rs17015466 | G | A | rs17015466 | 23648065 | 7.78E-05 | Dominant model | 1.4 | [1.15-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17015466-G | Research Support, Non-U.S. Gov't |
| 1 | 105725458 | rs6667576 | C | T | rs6667576 | 23648065 | 7.86E-05 | Allelic model | 1.88 | [1.36-2.60] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6667576-G | Research Support, Non-U.S. Gov't |
| 1 | 108302922 | rs12142335 | G | A | rs12142335 | 23648065 | 8.00E-06 | Dominant model | 9.71 | [3.17-29.71] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12142335-A | Research Support, Non-U.S. Gov't |
| 1 | 108315137 | rs4462178 | C | T | rs4462178 | 23648065 | 8.45E-06 | Dominant model | 9.71 | [3.17-29.71] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4462178-T | Research Support, Non-U.S. Gov't |
| 1 | 109392837 | rs1277203 | C | T | rs1277203 | 23648065 | 9.00E-06 | Recessive model | 1.62 | [1.24-2.10] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1277203-A | Research Support, Non-U.S. Gov't |
| 1 | 109783555 | rs4246519 | A | G | rs4246519 | 23648065 | 1.60E-05 | Allelic model | 1.7 | [1.34-2.15] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4246519-A | Research Support, Non-U.S. Gov't |
| 1 | 109784781 | rs586254 | A | G | rs586254 | 23648065 | 4.76E-05 | Allelic model | 1.65 | [1.30-2.10] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs586254-C | Research Support, Non-U.S. Gov't |
| 1 | 111087124 | rs2790372 | C | A | rs2790372 | 23648065 | 7.52E-05 | Dominant model | 3.06 | [1.60-5.88] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2790372-C | Research Support, Non-U.S. Gov't |
| 1 | 111089405 | rs1625029 | C | T | rs1625029 | 23648065 | 7.52E-05 | Dominant model | 3.06 | [1.60-5.88] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1625029-G | Research Support, Non-U.S. Gov't |
| 1 | 111100562 | rs6537668 | T | C | rs6537668 | 23648065 | 4.12E-05 | Allelic model | 1.79 | [1.35-2.39] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6537668-A | Research Support, Non-U.S. Gov't |
| 1 | 115774074 | rs971723 | A | C | rs971723 | 23648065 | 9.08E-05 | Recessive model | 1.54 | [1.10-2.16] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs971723-A | Research Support, Non-U.S. Gov't |
| 1 | 115782754 | rs7542599 | T | C | rs7542599 | 23648065 | 8.83E-05 | Recessive model | 1.51 | [1.08-2.12] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7542599-T | Research Support, Non-U.S. Gov't |
| 1 | 117367190 | rs6428670 | T | C | rs6428670 | 23648065 | 2.76E-05 | Recessive model | 1.39 | [1.07-1.81] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6428670-G | Research Support, Non-U.S. Gov't |
| 1 | 151673350 | rs1308145 | T | C | rs1308145 | 23648065 | 9.31E-05 | Recessive model | 1.57 | [1.22-2.02] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1308145-G | Research Support, Non-U.S. Gov't |
| 1 | 151679441 | rs1308152 | T | C | rs1308152 | 23648065 | 1.83E-05 | Recessive model | 2.05 | [1.42-2.97] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1308152-C | Research Support, Non-U.S. Gov't |
| 1 | 151679441 | rs1308152 | T | C | rs1308152 | 23648065 | 3.79E-05 | Recessive model | 1.66 | [1.28-2.15] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1308152-C | Research Support, Non-U.S. Gov't |
| 1 | 151684262 | rs3762302 | T | C | rs3762302 | 23648065 | 3.34E-05 | Dominant model | 1.7 | [1.20-2.41] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3762302-C | Research Support, Non-U.S. Gov't |
| 1 | 151778683 | rs9017 | C | T | rs9017 | 23648065 | 7.80E-05 | Recessive model | 1.5 | [1.16-1.94] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9017-G | Research Support, Non-U.S. Gov't |
| 1 | 154340789 | rs12025518 | A | C | rs12025518 | 23648065 | 6.26E-05 | Allelic model | 7.23 | [2.41-21.73] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12025518-T | Research Support, Non-U.S. Gov't |
| 1 | 159174683 | rs2814778 | T | C | rs2814778 | 21507922 | 1.00E-08 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 1 | 159582103 | rs10494331 | C | T | rs10494331 | 23648065 | 2.52E-05 | Allelic model | 2.76 | [1.72-4.44] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10494331-G | Research Support, Non-U.S. Gov't |
| 1 | 159582218 | rs4233355 | G | A | rs4233355 | 23648065 | 3.53E-05 | Allelic model | 2.77 | [1.71-4.47] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4233355-T | Research Support, Non-U.S. Gov't |
| 1 | 162061265 | rs4657140 | T | C | rs4657140 | pha003095 | 8.79E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4657140-T | NA |
| 1 | 162062044 | rs1415257 | C | T | rs1415257 | pha003095 | 9.45E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1415257-C | NA |
| 1 | 162085309 | rs1415259 | C | T | rs1415259 | pha003095 | 8.38E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1415259-C | NA |
| 1 | 162085685 | rs10494366 | G | T | rs10494366 | pha003095 | 8.38E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10494366-G | NA |
| 1 | 167803823 | rs3752608 | G | T | rs3752608 | 23648065 | 7.27E-05 | Allelic model | 3.7 | [1.98-6.92] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3752608-T | Research Support, Non-U.S. Gov't |
| 1 | 170856852 | rs10489239 | C | T | rs10489239 | 23648065 | 3.83E-05 | Dominant model | 1.51 | [1.18-1.92] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10489239-G | Research Support, Non-U.S. Gov't |
| 1 | 170858095 | rs10489241 | T | C | rs10489241 | 23648065 | 3.83E-05 | Dominant model | 1.5 | [1.17-1.91] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10489241-A | Research Support, Non-U.S. Gov't |
| 1 | 170860531 | rs12038181 | C | T | rs12038181 | 23648065 | 3.83E-05 | Dominant model | 1.5 | [1.17-1.91] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12038181-G | Research Support, Non-U.S. Gov't |
| 1 | 174246712 | rs6670617 | C | A | rs6670617 | 23648065 | 8.65E-05 | Recessive model | 1.54 | [1.22-1.94] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6670617-T | Research Support, Non-U.S. Gov't |
| 1 | 174258877 | rs4650989 | G | A | rs4650989 | 23648065 | 3.68E-05 | Recessive model | 1.55 | [1.23-1.96] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4650989-T | Research Support, Non-U.S. Gov't |
| 1 | 174266642 | rs7555067 | C | T | rs7555067 | 23648065 | 8.61E-05 | Recessive model | 1.55 | [1.23-1.96] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7555067-T | Research Support, Non-U.S. Gov't |
| 1 | 174312813 | rs17301013 | C | T | rs17301013 | 23648065 | 5.19E-05 | Recessive model | 1.59 | [1.26-2.01] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17301013-A | Research Support, Non-U.S. Gov't |
| 1 | 174497642 | rs12088073 | A | C | rs12088073 | 23648065 | 5.18E-05 | Recessive model | 1.47 | [1.17-1.86] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12088073-G | Research Support, Non-U.S. Gov't |
| 1 | 174499977 | rs6425284 | G | A | rs6425284 | 23648065 | 3.62E-05 | Recessive model | 1.49 | [1.18-1.88] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6425284-T | Research Support, Non-U.S. Gov't |
| 1 | 174499977 | rs6425284 | G | A | rs6425284 | 23648065 | 7.79E-05 | Recessive model | 1.62 | [1.24-2.12] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6425284-T | Research Support, Non-U.S. Gov't |
| 1 | 174592050 | rs6664864 | A | G | rs6664864 | 23648065 | 2.56E-05 | Recessive model | 1.52 | [1.20-1.91] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6664864-C | Research Support, Non-U.S. Gov't |
| 1 | 174818547 | rs3018410 | A | G | rs3018410 | 23648065 | 3.61E-05 | Recessive model | 1.52 | [1.20-1.92] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3018410-T | Research Support, Non-U.S. Gov't |
| 1 | 175391741 | rs6666777 | C | T | rs6666777 | 23648065 | 7.53E-05 | Recessive model | 1.67 | [1.17-2.40] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6666777-G | Research Support, Non-U.S. Gov't |
| 1 | 177271313 | rs16851037 | G | A | rs16851037 | 23648065 | 7.63E-05 | Recessive model | 1.21 | [0.92-1.60] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16851037-T | Research Support, Non-U.S. Gov't |
| 1 | 182420448 | rs267866 | G | A | rs267866 | 23648065 | 6.03E-05 | Allelic model | 3.18 | [1.73-5.85] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs267866-T | Research Support, Non-U.S. Gov't |
| 1 | 185341597 | rs4651254 | T | C | rs4651254 | 23648065 | 6.18E-05 | Allelic model | 1.43 | [1.20-1.71] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4651254-G | Research Support, Non-U.S. Gov't |
| 1 | 185347488 | rs10911713 | C | T | rs10911713 | 23648065 | 8.31E-05 | Allelic model | 1.45 | [1.21-1.75] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10911713-T | Research Support, Non-U.S. Gov't |
| 1 | 186163076 | rs1322375 | T | C | rs1322375 | 23648065 | 3.78E-05 | Allelic model | 2.42 | [1.61-3.66] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1322375-C | Research Support, Non-U.S. Gov't |
| 1 | 186172443 | rs1885522 | C | A | rs1885522 | 23648065 | 4.02E-05 | Allelic model | 2.38 | [1.60-3.54] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1885522-A | Research Support, Non-U.S. Gov't |
| 1 | 192940642 | rs12025826 | G | A | rs12025826 | 23648065 | 7.57E-05 | Dominant model | 1.75 | [1.23-2.47] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12025826-G | Research Support, Non-U.S. Gov't |
| 1 | 194591753 | rs13376197 | T | C | rs13376197 | 23648065 | 6.69E-05 | Dominant model | 5.69 | [2.36-13.70] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13376197-C | Research Support, Non-U.S. Gov't |
| 1 | 194910364 | rs6695766 | G | A | rs6695766 | 23648065 | 4.20E-05 | Allelic model | 2.92 | [1.68-5.08] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6695766-C | Research Support, Non-U.S. Gov't |
| 1 | 194965856 | rs11583374 | T | C | rs11583374 | 23648065 | 9.68E-05 | Allelic model | 2.64 | [1.56-4.46] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11583374-T | Research Support, Non-U.S. Gov't |
| 1 | 195367222 | rs1987929 | T | C | rs1987929 | 23648065 | 9.62E-05 | Allelic model | 2.4 | [1.53-3.74] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1987929-G | Research Support, Non-U.S. Gov't |
| 1 | 198469162 | rs10922438 | G | A | rs10922438 | 23648065 | 6.00E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10922438-T | Research Support, Non-U.S. Gov't |
| 1 | 198481371 | rs12058080 | C | T | rs12058080 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12058080-T | Research Support, Non-U.S. Gov't |
| 1 | 198484209 | rs2359847 | C | T | rs2359847 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2359847-T | Research Support, Non-U.S. Gov't |
| 1 | 198484784 | rs16843226 | A | G | rs16843226 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16843226-C | Research Support, Non-U.S. Gov't |
| 1 | 198485706 | rs12083381 | T | C | rs12083381 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12083381-C | Research Support, Non-U.S. Gov't |
| 1 | 198489457 | rs10494777 | T | C | rs10494777 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10494777-C | Research Support, Non-U.S. Gov't |
| 1 | 198494473 | rs10922446 | C | T | rs10922446 | 23648065 | 6.01E-06 | Allelic model | 2.3 | [1.61-3.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10922446-A | Research Support, Non-U.S. Gov't |
| 1 | 201101413 | rs6697303 | C | T | rs6697303 | 23648065 | 3.81E-05 | Dominant model | 2.54 | [1.54-4.20] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6697303-T | Research Support, Non-U.S. Gov't |
| 1 | 201429381 | rs12090950 | G | A | rs12090950 | 23648065 | 1.76E-05 | Allelic model | 2.18 | [1.54-3.08] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12090950-T | Research Support, Non-U.S. Gov't |
| 1 | 201429381 | rs12090950 | G | A | rs12090950 | 23648065 | 4.64E-05 | Allelic model | 2.45 | [1.62-3.70] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12090950-T | Research Support, Non-U.S. Gov't |
| 1 | 201775746 | rs4379719 | G | A | rs4379719 | 23648065 | 2.45E-05 | Dominant model | 2.44 | [1.57-3.78] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4379719-C | Research Support, Non-U.S. Gov't |
| 1 | 204006104 | rs4951290 | T | G | rs4951290 | 23648065 | 8.52E-05 | Dominant model | 2.82 | [1.64-4.85] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4951290-C | Research Support, Non-U.S. Gov't |
| 1 | 206714818 | rs9661909 | C | T | rs9661909 | 23648065 | 2.07E-05 | Recessive model | 1.7 | [1.15-2.51] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9661909-C | Research Support, Non-U.S. Gov't |
| 1 | 207143422 | rs1856746 | A | G | rs1856746 | 23648065 | 8.46E-05 | Allelic model | 1.67 | [1.29-2.16] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1856746-T | Research Support, Non-U.S. Gov't |
| 1 | 207162433 | rs2791708 | T | C | rs2791708 | 23648065 | 7.67E-05 | Allelic model | 1.69 | [1.30-2.19] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2791708-T | Research Support, Non-U.S. Gov't |
| 1 | 208578200 | rs710417 | G | A | rs710417 | 23648065 | 7.72E-05 | Recessive model | 1.64 | [1.17-2.31] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs710417-T | Research Support, Non-U.S. Gov't |
| 1 | 209581483 | rs1988163 | C | A | rs1988163 | 23648065 | 3.12E-05 | Dominant model | 1.88 | [1.29-2.73] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1988163-G | Research Support, Non-U.S. Gov't |
| 1 | 211666218 | rs10863899 | A | G | rs10863899 | 23648065 | 2.50E-05 | Recessive model | 1.22 | [0.91-1.66] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10863899-A | Research Support, Non-U.S. Gov't |
| 1 | 211672506 | rs755448 | G | A | rs755448 | 23648065 | 2.37E-05 | Recessive model | 1.24 | [0.90-1.71] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs755448-G | Research Support, Non-U.S. Gov't |
| 1 | 212757658 | rs4543871 | T | C | rs4543871 | 23648065 | 2.54E-05 | Allelic model | 2.48 | [1.63-3.78] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4543871-G | Research Support, Non-U.S. Gov't |
| 1 | 212757658 | rs4543871 | T | C | rs4543871 | 23648065 | 5.17E-05 | Allelic model | 2.19 | [1.51-3.17] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4543871-G | Research Support, Non-U.S. Gov't |
| 1 | 213120103 | rs6656706 | C | T | rs6656706 | 23648065 | 9.07E-05 | Allelic model | 1.74 | [1.31-2.30] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6656706-C | Research Support, Non-U.S. Gov't |
| 1 | 216705965 | rs6696225 | T | C | rs6696225 | 23648065 | 1.34E-05 | Recessive model | 1.28 | [1.07-1.54] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6696225-C | Research Support, Non-U.S. Gov't |
| 1 | 216707012 | rs1833036 | G | T | rs1833036 | 23648065 | 1.46E-05 | Recessive model | 1.28 | [1.06-1.54] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1833036-A | Research Support, Non-U.S. Gov't |
| 1 | 216715514 | rs2377098 | G | T | rs2377098 | 23648065 | 3.33E-06 | Recessive model | 1.33 | [1.10-1.61] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2377098-T | Research Support, Non-U.S. Gov't |
| 1 | 216716320 | rs12145418 | G | T | rs12145418 | 23648065 | 2.00E-06 | Recessive model | 1.33 | [1.10-1.60] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12145418-T | Research Support, Non-U.S. Gov't |
| 1 | 216726333 | rs10442688 | T | C | rs10442688 | 23648065 | 6.60E-06 | Recessive model | 1.3 | [1.08-1.57] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10442688-G | Research Support, Non-U.S. Gov't |
| 1 | 216727323 | rs4846528 | C | T | rs4846528 | 23648065 | 3.43E-05 | Recessive model | 1.28 | [1.06-1.54] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4846528-A | Research Support, Non-U.S. Gov't |
| 1 | 216966601 | rs7355008 | T | C | rs7355008 | 23648065 | 9.82E-05 | Allelic model | 1.46 | [1.21-1.77] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7355008-C | Research Support, Non-U.S. Gov't |
| 1 | 218128141 | rs17691163 | G | A | rs17691163 | 23648065 | 3.88E-05 | Allelic model | 4.21 | [2.13-8.35] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17691163-T | Research Support, Non-U.S. Gov't |
| 1 | 218439928 | rs1338445 | T | C | rs1338445 | 23648065 | 2.81E-05 | Recessive model | 1.91 | [1.24-2.94] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1338445-G | Research Support, Non-U.S. Gov't |
| 1 | 219176608 | rs7540160 | A | G | rs7540160 | 23648065 | 9.91E-05 | Recessive model | 1.55 | [1.19-2.02] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7540160-T | Research Support, Non-U.S. Gov't |
| 1 | 225508712 | rs648011 | C | T | rs648011 | 23648065 | 8.52E-05 | Recessive model | 1.58 | [1.13-2.21] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs648011-A | Research Support, Non-U.S. Gov't |
| 1 | 231922845 | rs11590192 | T | C | rs11590192 | 23648065 | 8.22E-05 | Dominant model | 1.9 | [1.36-2.67] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11590192-G | Research Support, Non-U.S. Gov't |
| 1 | 234701910 | rs9970996 | G | A | rs9970996 | 23648065 | 9.51E-05 | Recessive model | 1.25 | [0.94-1.66] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9970996-C | Research Support, Non-U.S. Gov't |
| 1 | 234769793 | rs9803801 | C | T | rs9803801 | 23648065 | 5.14E-05 | Dominant model | 4.63 | [1.97-10.87] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9803801-G | Research Support, Non-U.S. Gov't |
| 1 | 240091765 | rs6666471 | G | A | rs6666471 | 23648065 | 5.15E-05 | Recessive model | 1.36 | [1.15-1.61] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6666471-C | Research Support, Non-U.S. Gov't |
| 1 | 244508697 | rs4658624 | A | G | rs4658624 | 23648065 | 4.97E-05 | Allelic model | 1.68 | [1.31-2.16] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4658624-A | Research Support, Non-U.S. Gov't |
| 1 | 248519821 | rs1538703 | T | G | rs1538703 | 23648065 | 2.98E-05 | Dominant model | 2.44 | [1.42-4.22] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1538703-G | Research Support, Non-U.S. Gov't |
| 1 | 248521032 | rs946761 | T | C | rs946761 | 23648065 | 6.73E-05 | Dominant model | 2.4 | [1.41-4.11] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs946761-C | Research Support, Non-U.S. Gov't |
| 2 | 773278 | rs4380275 | C | T | rs4380275 | 23648065 | 5.00E-06 | Recessive model | 3.6 | [2.04-6.37] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4380275-G | Research Support, Non-U.S. Gov't |
| 2 | 2764201 | rs1031348 | C | A | rs1031348 | 23648065 | 2.42E-05 | Dominant model | 1.7 | [1.29-2.23] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1031348-G | Research Support, Non-U.S. Gov't |
| 2 | 2978905 | rs17437842 | C | T | rs17437842 | 23648065 | 8.24E-05 | Dominant model | 1.82 | [1.32-2.50] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17437842-G | Research Support, Non-U.S. Gov't |
| 2 | 5891097 | rs13391560 | A | G | rs13391560 | 23648065 | 6.64E-05 | Allelic model | 3.51 | [1.89-6.52] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13391560-A | Research Support, Non-U.S. Gov't |
| 2 | 8949070 | rs7587928 | T | C | rs7587928 | 21507922 | 2.00E-07 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 2 | 9988348 | rs1469544 | T | G | rs1469544 | 23648065 | 5.98E-05 | Dominant model | 1.6 | [1.23-2.08] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1469544-T | Research Support, Non-U.S. Gov't |
| 2 | 9989442 | rs16867195 | A | G | rs16867195 | 23648065 | 6.07E-05 | Dominant model | 1.6 | [1.23-2.08] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16867195-A | Research Support, Non-U.S. Gov't |
| 2 | 9996156 | rs1014509 | T | C | rs1014509 | 23648065 | 5.87E-05 | Dominant model | 1.61 | [1.24-2.09] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1014509-A | Research Support, Non-U.S. Gov't |
| 2 | 14881995 | rs7607607 | A | C | rs7607607 | 23648065 | 8.96E-05 | Recessive model | 1.31 | [0.90-1.90] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7607607-A | Research Support, Non-U.S. Gov't |
| 2 | 18314546 | rs12471785 | G | A | rs12471785 | 23648065 | 7.04E-05 | Dominant model | 1.53 | [1.20-1.96] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12471785-G | Research Support, Non-U.S. Gov't |
| 2 | 20335709 | rs4666360 | G | A | rs4666360 | 23648065 | 3.00E-06 | Dominant model | 2.14 | [1.55-2.95] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4666360-C | Research Support, Non-U.S. Gov't |
| 2 | 20346651 | rs981396 | G | A | rs981396 | 23648065 | 4.72E-05 | Allelic model | 2.02 | [1.44-2.83] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs981396-T | Research Support, Non-U.S. Gov't |
| 2 | 23300822 | rs1446875 | T | C | rs1446875 | 23648065 | 2.85E-05 | Recessive model | 1.59 | [1.13-2.23] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1446875-C | Research Support, Non-U.S. Gov't |
| 2 | 25038268 | rs2082881 | G | A | rs2082881 | 23648065 | 3.72E-05 | Dominant model | 2.54 | [1.57-4.13] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2082881-C | Research Support, Non-U.S. Gov't |
| 2 | 25041620 | rs1550115 | C | T | rs1550115 | 23648065 | 3.72E-05 | Dominant model | 2.54 | [1.57-4.13] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1550115-C | Research Support, Non-U.S. Gov't |
| 2 | 25482970 | rs11694842 | A | G | rs11694842 | 23648065 | 4.19E-05 | Dominant model | 2.12 | [1.49-3.03] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11694842-C | Research Support, Non-U.S. Gov't |
| 2 | 32444054 | rs212701 | T | C | rs212701 | 23648065 | 2.43E-05 | Recessive model | 1.54 | [1.20-1.96] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs212701-G | Research Support, Non-U.S. Gov't |
| 2 | 32447718 | rs177083 | C | T | rs177083 | 23648065 | 2.43E-05 | Recessive model | 1.56 | [1.22-1.99] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs177083-T | Research Support, Non-U.S. Gov't |
| 2 | 32450348 | rs212704 | C | T | rs212704 | 23648065 | 3.20E-05 | Recessive model | 1.58 | [1.23-2.02] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs212704-A | Research Support, Non-U.S. Gov't |
| 2 | 32475109 | rs455060 | G | A | rs455060 | 23648065 | 2.43E-05 | Recessive model | 1.58 | [1.24-2.02] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs455060-A | Research Support, Non-U.S. Gov't |
| 2 | 34499749 | rs6719309 | A | C | rs6719309 | 23648065 | 2.08E-05 | Allelic model | 1.8 | [1.37-2.37] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6719309-T | Research Support, Non-U.S. Gov't |
| 2 | 34542730 | rs6721933 | G | T | rs6721933 | 23648065 | 9.65E-05 | Recessive model | 1.59 | [1.21-2.08] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6721933-T | Research Support, Non-U.S. Gov't |
| 2 | 36386902 | rs12614272 | T | C | rs12614272 | pha003095 | 2.29E-05 | phs000221 | phs000501 | 0.3 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs12614272-C | NA |
| 2 | 36625388 | rs3770935 | C | T | rs3770935 | 23648065 | 4.67E-05 | Recessive model | 1.69 | [1.26-2.28] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3770935-A | Research Support, Non-U.S. Gov't |
| 2 | 36627725 | rs4670145 | A | G | rs4670145 | 23648065 | 8.74E-05 | Recessive model | 1.62 | [1.20-2.18] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4670145-C | Research Support, Non-U.S. Gov't |
| 2 | 38178362 | rs2197561 | T | C | rs2197561 | 23648065 | 9.89E-05 | Dominant model | 1.28 | [1.08-1.52] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2197561-G | Research Support, Non-U.S. Gov't |
| 2 | 40354688 | rs2110927 | C | T | rs2110927 | 23648065 | 5.34E-05 | Allelic model | 2.75 | [1.65-4.61] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2110927-T | Research Support, Non-U.S. Gov't |
| 2 | 40357323 | rs2160364 | T | C | rs2160364 | 23648065 | 9.64E-05 | Allelic model | 2.61 | [1.58-4.34] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2160364-A | Research Support, Non-U.S. Gov't |
| 2 | 40358175 | rs765554 | G | A | rs765554 | 23648065 | 2.87E-05 | Allelic model | 1.96 | [1.43-2.68] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs765554-C | Research Support, Non-U.S. Gov't |
| 2 | 40363644 | rs2110922 | C | A | rs2110922 | 23648065 | 9.03E-05 | Allelic model | 1.82 | [1.35-2.47] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2110922-T | Research Support, Non-U.S. Gov't |
| 2 | 40376453 | rs2058693 | T | G | rs2058693 | 23648065 | 8.81E-05 | Allelic model | 1.87 | [1.37-2.55] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2058693-G | Research Support, Non-U.S. Gov't |
| 2 | 40381369 | rs13425134 | A | G | rs13425134 | 23648065 | 9.20E-05 | Allelic model | 2.47 | [1.54-3.96] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13425134-G | Research Support, Non-U.S. Gov't |
| 2 | 40384733 | rs452369 | C | T | rs452369 | 23648065 | 9.20E-05 | Allelic model | 2.47 | [1.54-3.96] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs452369-G | Research Support, Non-U.S. Gov't |
| 2 | 41036518 | rs6722048 | G | A | rs6722048 | 23648065 | 7.99E-05 | Recessive model | 1.48 | [1.08-2.03] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6722048-A | Research Support, Non-U.S. Gov't |
| 2 | 41273631 | rs17027130 | T | C | rs17027130 | 23648065 | 3.00E-06 | Allelic model | 2.87 | [1.84-4.45] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17027130-C | Research Support, Non-U.S. Gov't |
| 2 | 42015775 | rs6704827 | T | G | rs6704827 | 23648065 | 7.74E-05 | Dominant model | 1.56 | [1.20-2.04] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6704827-A | Research Support, Non-U.S. Gov't |
| 2 | 44554724 | rs4953085 | A | G | rs4953085 | 23648065 | 8.42E-05 | Allelic model | 1.72 | [1.32-2.25] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4953085-G | Research Support, Non-U.S. Gov't |
| 2 | 45506771 | rs12476712 | C | T | rs12476712 | 23648065 | 3.83E-05 | Allelic model | 4.01 | [2.06-7.81] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12476712-G | Research Support, Non-U.S. Gov't |
| 2 | 47372425 | rs726117 | G | A | rs726117 | 23648065 | 7.41E-05 | Allelic model | 1.76 | [1.33-2.33] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs726117-A | Research Support, Non-U.S. Gov't |
| 2 | 48039484 | rs10490303 | T | G | rs10490303 | pha003095 | 7.11E-05 | phs000221 | phs000501 | 0.43 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10490303-G | NA |
| 2 | 48150587 | rs7588761 | C | T | rs7588761 | pha003095 | 8.36E-05 | phs000221 | phs000501 | 0.43 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7588761-T | NA |
| 2 | 48174199 | rs6729916 | T | C | rs6729916 | pha003095 | 3.85E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6729916-T | NA |
| 2 | 48193108 | rs10199698 | T | C | rs10199698 | pha003095 | 3.19E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10199698-T | NA |
| 2 | 48197968 | rs10183748 | C | T | rs10183748 | pha003095 | 3.12E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10183748-T | NA |
| 2 | 49715021 | rs12987465 | G | A | rs12987465 | 23648065 | 7.00E-06 | Recessive model | 2.6 | [1.42-4.74] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12987465-A | Research Support, Non-U.S. Gov't |
| 2 | 49732935 | rs1553127 | T | C | rs1553127 | 23648065 | 1.85E-05 | Dominant model | 1.88 | [1.40-2.52] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1553127-T | Research Support, Non-U.S. Gov't |
| 2 | 49732935 | rs1553127 | T | C | rs1553127 | 23648065 | 5.80E-05 | Dominant model | 1.93 | [1.40-2.67] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1553127-T | Research Support, Non-U.S. Gov't |
| 2 | 49737819 | rs1405965 | A | G | rs1405965 | 23648065 | 2.27E-05 | Dominant model | 1.95 | [1.42-2.67] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1405965-T | Research Support, Non-U.S. Gov't |
| 2 | 49737819 | rs1405965 | A | G | rs1405965 | 23648065 | 3.87E-05 | Dominant model | 1.78 | [1.34-2.37] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1405965-T | Research Support, Non-U.S. Gov't |
| 2 | 49749038 | rs6709183 | C | T | rs6709183 | 23648065 | 7.52E-05 | Dominant model | 1.7 | [1.27-2.27] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6709183-A | Research Support, Non-U.S. Gov't |
| 2 | 49752589 | rs4971621 | T | C | rs4971621 | 23648065 | 6.76E-05 | Recessive model | 2.6 | [1.42-4.74] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4971621-A | Research Support, Non-U.S. Gov't |
| 2 | 49852392 | rs1391749 | A | C | rs1391749 | 23648065 | 2.26E-05 | Allelic model | 2.27 | [1.56-3.30] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1391749-C | Research Support, Non-U.S. Gov't |
| 2 | 56656894 | rs1861776 | A | G | rs1861776 | 23648065 | 1.84E-05 | Allelic model | 2.3 | [1.56-3.39] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1861776-G | Research Support, Non-U.S. Gov't |
| 2 | 56682547 | rs13397156 | C | A | rs13397156 | 23648065 | 2.64E-05 | Allelic model | 2.29 | [1.55-3.38] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13397156-A | Research Support, Non-U.S. Gov't |
| 2 | 57147590 | rs7589657 | C | T | rs7589657 | 23648065 | 4.24E-05 | Dominant model | 1.52 | [1.21-1.90] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7589657-A | Research Support, Non-U.S. Gov't |
| 2 | 57174489 | rs7578236 | C | T | rs7578236 | 23648065 | 8.15E-05 | Allelic model | 1.42 | [1.19-1.68] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7578236-T | Research Support, Non-U.S. Gov't |
| 2 | 57174489 | rs7578236 | C | T | rs7578236 | 23648065 | 8.58E-05 | Allelic model | 1.59 | [1.26-1.99] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7578236-T | Research Support, Non-U.S. Gov't |
| 2 | 57436631 | rs7604249 | T | C | rs7604249 | 23648065 | 9.01E-05 | Allelic model | 1.43 | [1.19-1.71] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7604249-G | Research Support, Non-U.S. Gov't |
| 2 | 57696957 | rs17048844 | T | C | rs17048844 | 23648065 | 4.53E-05 | Recessive model | 1.79 | [1.24-2.58] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17048844-G | Research Support, Non-U.S. Gov't |
| 2 | 57696957 | rs17048844 | T | C | rs17048844 | 23648065 | 7.02E-05 | Allelic model | 1.43 | [1.20-1.70] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17048844-G | Research Support, Non-U.S. Gov't |
| 2 | 63815801 | rs2278718 | A | C | rs2278718 | 23648065 | 7.51E-05 | Recessive model | 1.37 | [1.11-1.69] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2278718-C | Research Support, Non-U.S. Gov't |
| 2 | 70736219 | rs454305 | A | G | rs454305 | 21507922 | 5.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 2 | 75186337 | rs2287102 | A | G | rs2287102 | 23648065 | 1.93E-05 | Dominant model | 1.53 | [1.23-1.90] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2287102-A | Research Support, Non-U.S. Gov't |
| 2 | 75290700 | rs13404785 | A | G | rs13404785 | 23648065 | 5.86E-05 | Dominant model | 1.41 | [1.17-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13404785-T | Research Support, Non-U.S. Gov't |
| 2 | 75291510 | rs3755457 | G | A | rs3755457 | 23648065 | 9.76E-05 | Dominant model | 1.4 | [1.17-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3755457-G | Research Support, Non-U.S. Gov't |
| 2 | 80185885 | rs747921 | A | G | rs747921 | 23648065 | 6.38E-05 | Dominant model | 2.59 | [1.42-4.72] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs747921-A | Research Support, Non-U.S. Gov't |
| 2 | 80228740 | rs1368909 | T | C | rs1368909 | 23648065 | 1.26E-05 | Dominant model | 1.85 | [1.34-2.53] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1368909-G | Research Support, Non-U.S. Gov't |
| 2 | 106310212 | rs11884955 | T | C | rs11884955 | 23648065 | 5.96E-05 | Recessive model | 1.21 | [0.92-1.60] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11884955-G | Research Support, Non-U.S. Gov't |
| 2 | 111740221 | rs11123271 | A | G | rs11123271 | 23648065 | 6.82E-05 | Allelic model | 1.66 | [1.30-2.13] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11123271-G | Research Support, Non-U.S. Gov't |
| 2 | 111753228 | rs6542248 | C | A | rs6542248 | 23648065 | 2.32E-05 | Allelic model | 1.74 | [1.35-2.25] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6542248-G | Research Support, Non-U.S. Gov't |
| 2 | 111787027 | rs1561476 | C | T | rs1561476 | 23648065 | 3.95E-05 | Allelic model | 1.72 | [1.33-2.23] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1561476-G | Research Support, Non-U.S. Gov't |
| 2 | 114637231 | rs6720853 | C | T | rs6720853 | 23648065 | 5.31E-05 | Dominant model | 2.36 | [1.47-3.80] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6720853-T | Research Support, Non-U.S. Gov't |
| 2 | 114672304 | rs12618683 | A | G | rs12618683 | 23648065 | 5.31E-05 | Dominant model | 2.28 | [1.42-3.66] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12618683-G | Research Support, Non-U.S. Gov't |
| 2 | 115573050 | rs2420449 | A | G | rs2420449 | pha003095 | 8.17E-06 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2420449-A | NA |
| 2 | 122936737 | rs1432312 | T | C | rs1432312 | 23648065 | 7.82E-05 | Allelic model | 1.78 | [1.33-2.39] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1432312-T | Research Support, Non-U.S. Gov't |
| 2 | 125061838 | rs733112 | C | A | rs733112 | 23648065 | 1.09E-05 | Dominant model | 2.06 | [1.43-2.98] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs733112-T | Research Support, Non-U.S. Gov't |
| 2 | 129457798 | rs10928827 | A | G | rs10928827 | 23648065 | 8.59E-05 | Dominant model | 1.67 | [1.21-2.28] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10928827-A | Research Support, Non-U.S. Gov't |
| 2 | 130024589 | rs837898 | A | G | rs837898 | 23648065 | 9.33E-06 | Recessive model | 1.28 | [0.93-1.76] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs837898-G | Research Support, Non-U.S. Gov't |
| 2 | 130034012 | rs837841 | C | A | rs837841 | 23648065 | 8.00E-06 | Recessive model | 1.28 | [0.93-1.76] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs837841-T | Research Support, Non-U.S. Gov't |
| 2 | 133471789 | rs10166009 | C | T | rs10166009 | 23648065 | 3.46E-05 | Dominant model | 1.99 | [1.35-2.93] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10166009-G | Research Support, Non-U.S. Gov't |
| 2 | 134442532 | rs6430443 | A | G | rs6430443 | 23648065 | 8.61E-04 | Recessive model | 6.33 | [1.90-22.22] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6430443-G | Research Support, Non-U.S. Gov't |
| 2 | 143746849 | rs1050950 | C | A | rs1050950 | 23648065 | 7.18E-05 | Dominant model | 1.22 | [1.03-1.45] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1050950-T | Research Support, Non-U.S. Gov't |
| 2 | 143749073 | rs1371514 | G | A | rs1371514 | 23648065 | 7.18E-05 | Dominant model | 1.22 | [1.03-1.45] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1371514-T | Research Support, Non-U.S. Gov't |
| 2 | 143751071 | rs12466715 | A | G | rs12466715 | 23648065 | 9.24E-05 | Dominant model | 1.22 | [1.03-1.44] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12466715-G | Research Support, Non-U.S. Gov't |
| 2 | 143931505 | rs354696 | G | A | rs354696 | 23648065 | 4.29E-05 | Allelic model | 3.74 | [1.97-7.10] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs354696-C | Research Support, Non-U.S. Gov't |
| 2 | 148305357 | rs16827511 | C | A | rs16827511 | 23648065 | 1.36E-05 | Dominant model | 3.94 | [1.97-7.86] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16827511-C | Research Support, Non-U.S. Gov't |
| 2 | 148318521 | rs12464146 | T | C | rs12464146 | 23648065 | 1.36E-05 | Dominant model | 3.94 | [1.97-7.86] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12464146-T | Research Support, Non-U.S. Gov't |
| 2 | 148318521 | rs12464146 | T | C | rs12464146 | 23648065 | 2.44E-05 | Dominant model | 6.01 | [2.13-17.00] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12464146-T | Research Support, Non-U.S. Gov't |
| 2 | 151345113 | rs2222760 | G | A | rs2222760 | 23648065 | 5.37E-05 | Recessive model | 1.29 | [0.92-1.80] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2222760-T | Research Support, Non-U.S. Gov't |
| 2 | 155652357 | rs1037091 | C | T | rs1037091 | 23648065 | 9.76E-05 | Dominant model | 1.49 | [1.19-1.87] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1037091-T | Research Support, Non-U.S. Gov't |
| 2 | 161118687 | rs10170600 | T | C | rs10170600 | 23648065 | 8.38E-05 | Dominant model | 2.15 | [1.38-3.34] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10170600-T | Research Support, Non-U.S. Gov't |
| 2 | 161133471 | rs3772070 | T | C | rs3772070 | 23648065 | 3.20E-05 | Dominant model | 2.31 | [1.47-3.64] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3772070-T | Research Support, Non-U.S. Gov't |
| 2 | 161166234 | rs4077463 | A | G | rs4077463 | 23648065 | 6.55E-05 | Dominant model | 2.53 | [1.57-4.07] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4077463-A | Research Support, Non-U.S. Gov't |
| 2 | 161192070 | rs4410242 | A | G | rs4410242 | 23648065 | 6.55E-05 | Dominant model | 2.53 | [1.57-4.07] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4410242-A | Research Support, Non-U.S. Gov't |
| 2 | 161214175 | rs6718526 | T | C | rs6718526 | 23648065 | 2.02E-05 | Dominant model | 2.81 | [1.71-4.63] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6718526-A | Research Support, Non-U.S. Gov't |
| 2 | 168772522 | rs836664 | A | G | rs836664 | 23648065 | 1.51E-05 | Allelic model | 2.15 | [1.50-3.08] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs836664-A | Research Support, Non-U.S. Gov't |
| 2 | 168775061 | rs7576460 | C | A | rs7576460 | 23648065 | 1.51E-05 | Allelic model | 2.15 | [1.50-3.08] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7576460-C | Research Support, Non-U.S. Gov't |
| 2 | 175893333 | rs1150186 | T | C | rs1150186 | 23648065 | 3.08E-05 | Recessive model | 1.3 | [1.05-1.60] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1150186-T | Research Support, Non-U.S. Gov't |
| 2 | 188482933 | rs7561970 | A | G | rs7561970 | 23648065 | 2.74E-05 | Allelic model | 1.54 | [1.26-1.89] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7561970-C | Research Support, Non-U.S. Gov't |
| 2 | 188684507 | rs4471853 | A | G | rs4471853 | 23648065 | 7.21E-05 | Dominant model | 1.85 | [1.33-2.57] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4471853-C | Research Support, Non-U.S. Gov't |
| 2 | 192465598 | rs6706693 | C | T | rs6706693 | 23648065 | 9.00E-06 | Recessive model | 1.74 | [1.36-2.23] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6706693-A | Research Support, Non-U.S. Gov't |
| 2 | 192469816 | rs4134381 | G | A | rs4134381 | 23648065 | 2.13E-05 | Allelic model | 1.73 | [1.35-2.22] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4134381-T | Research Support, Non-U.S. Gov't |
| 2 | 192470385 | rs4318338 | C | T | rs4318338 | 23648065 | 2.86E-05 | Allelic model | 1.73 | [1.35-2.21] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4318338-G | Research Support, Non-U.S. Gov't |
| 2 | 192473543 | rs4853629 | C | T | rs4853629 | 23648065 | 4.92E-05 | Allelic model | 1.68 | [1.31-2.15] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4853629-A | Research Support, Non-U.S. Gov't |
| 2 | 192479007 | rs3935827 | A | G | rs3935827 | 23648065 | 4.35E-05 | Allelic model | 1.7 | [1.33-2.18] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3935827-T | Research Support, Non-U.S. Gov't |
| 2 | 192479674 | rs4401164 | A | G | rs4401164 | 23648065 | 4.37E-05 | Allelic model | 1.7 | [1.33-2.17] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4401164-T | Research Support, Non-U.S. Gov't |
| 2 | 192490640 | rs11899661 | A | G | rs11899661 | 23648065 | 4.36E-05 | Allelic model | 1.7 | [1.33-2.17] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11899661-T | Research Support, Non-U.S. Gov't |
| 2 | 192491453 | rs6434494 | A | G | rs6434494 | 23648065 | 4.51E-05 | Allelic model | 1.69 | [1.32-2.16] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6434494-A | Research Support, Non-U.S. Gov't |
| 2 | 192506225 | rs6434497 | G | T | rs6434497 | 23648065 | 9.31E-05 | Recessive model | 1.58 | [1.24-2.02] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6434497-G | Research Support, Non-U.S. Gov't |
| 2 | 192510265 | rs5008133 | T | C | rs5008133 | 23648065 | 3.28E-05 | Recessive model | 1.6 | [1.25-2.05] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs5008133-A | Research Support, Non-U.S. Gov't |
| 2 | 196365890 | rs4591358 | T | C | rs4591358 | 23648065 | 7.00E-06 | Allelic model | 1.58 | [1.30-1.92] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4591358-C | Research Support, Non-U.S. Gov't |
| 2 | 198987935 | rs988583 | C | A | rs988583 | 21507922 | 6.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 2 | 200638509 | rs12615435 | T | G | rs12615435 | 23648065 | 4.00E-06 | Allelic model | 2.21 | [1.56-3.15] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12615435-T | Research Support, Non-U.S. Gov't |
| 2 | 207418899 | rs3770977 | C | T | rs3770977 | 23648065 | 1.28E-05 | Allelic model | 2.97 | [1.75-5.04] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3770977-C | Research Support, Non-U.S. Gov't |
| 2 | 214940734 | rs6715771 | T | C | rs6715771 | 23648065 | 2.02E-05 | Dominant model | 3.49 | [1.94-6.26] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6715771-C | Research Support, Non-U.S. Gov't |
| 2 | 215179277 | rs6731110 | C | A | rs6731110 | 23648065 | 9.24E-05 | Dominant model | 2.51 | [1.44-4.38] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6731110-C | Research Support, Non-U.S. Gov't |
| 2 | 217827849 | rs2372928 | A | G | rs2372928 | 23648065 | 5.70E-05 | Recessive model | 1.46 | [1.16-1.84] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2372928-A | Research Support, Non-U.S. Gov't |
| 2 | 217971141 | rs2372972 | T | C | rs2372972 | 23648065 | 8.94E-05 | Allelic model | 2.43 | [1.55-3.83] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2372972-C | Research Support, Non-U.S. Gov't |
| 2 | 217974444 | rs13015994 | A | C | rs13015994 | 23648065 | 2.08E-05 | Allelic model | 2.59 | [1.68-4.00] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13015994-G | Research Support, Non-U.S. Gov't |
| 2 | 217980433 | rs12466929 | G | A | rs12466929 | 23648065 | 1.97E-05 | Allelic model | 2.68 | [1.69-4.24] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12466929-C | Research Support, Non-U.S. Gov't |
| 2 | 218512598 | rs6733585 | A | G | rs6733585 | 23648065 | 5.48E-05 | Dominant model | 8.66 | [2.73-27.43] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6733585-A | Research Support, Non-U.S. Gov't |
| 2 | 218754326 | rs10174633 | T | C | rs10174633 | 23648065 | 1.57E-05 | Dominant model | 1.39 | [1.18-1.65] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10174633-A | Research Support, Non-U.S. Gov't |
| 2 | 220926429 | rs4674493 | C | T | rs4674493 | 23648065 | 9.28E-05 | Dominant model | 2.09 | [1.43-3.06] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4674493-G | Research Support, Non-U.S. Gov't |
| 2 | 221000018 | rs12614221 | G | T | rs12614221 | 23648065 | 3.51E-05 | Recessive model | 2.02 | [1.43-2.84] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12614221-A | Research Support, Non-U.S. Gov't |
| 2 | 221762952 | rs830747 | G | A | rs830747 | 23648065 | 1.59E-05 | Allelic model | 3.83 | [2.06-7.11] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs830747-G | Research Support, Non-U.S. Gov't |
| 2 | 221927852 | rs9808155 | G | T | rs9808155 | 23648065 | 3.45E-05 | Recessive model | 1.5 | [1.19-1.89] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9808155-A | Research Support, Non-U.S. Gov't |
| 2 | 222330970 | rs1430216 | T | C | rs1430216 | 23648065 | 6.26E-05 | Allelic model | 2.59 | [1.56-4.30] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1430216-T | Research Support, Non-U.S. Gov't |
| 2 | 224943685 | rs6740660 | G | A | rs6740660 | 23648065 | 4.00E-06 | Allelic model | 3.39 | [1.87-6.13] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6740660-G | Research Support, Non-U.S. Gov't |
| 2 | 232077075 | rs5018532 | A | G | rs5018532 | 23648065 | 1.72E-05 | Recessive model | 1.46 | [1.07-1.97] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs5018532-G | Research Support, Non-U.S. Gov't |
| 2 | 232077075 | rs5018532 | A | G | rs5018532 | 23648065 | 6.74E-05 | Recessive model | 1.13 | [0.92-1.39] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs5018532-G | Research Support, Non-U.S. Gov't |
| 2 | 232077670 | rs16827863 | T | C | rs16827863 | 23648065 | 1.72E-05 | Recessive model | 1.46 | [1.07-1.97] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16827863-C | Research Support, Non-U.S. Gov't |
| 2 | 232077670 | rs16827863 | T | C | rs16827863 | 23648065 | 6.89E-05 | Recessive model | 1.13 | [0.92-1.39] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16827863-C | Research Support, Non-U.S. Gov't |
| 2 | 234669144 | rs4148323 | G | A | rs4148323 | 23648065 | 9.68E-05 | Recessive model | 1.64 | [1.09-2.46] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4148323-A | Research Support, Non-U.S. Gov't |
| 2 | 234888161 | rs10207672 | T | C | rs10207672 | 23648065 | 7.09E-05 | Allelic model | 2.33 | [1.53-3.53] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10207672-C | Research Support, Non-U.S. Gov't |
| 2 | 236589977 | rs6750322 | A | G | rs6750322 | 23648065 | 3.51E-05 | Recessive model | 1.43 | [1.09-1.87] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6750322-C | Research Support, Non-U.S. Gov't |
| 2 | 236813557 | rs6747286 | T | C | rs6747286 | 23648065 | 9.91E-05 | Recessive model | 1.34 | [1.05-1.69] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6747286-C | Research Support, Non-U.S. Gov't |
| 2 | 236832573 | rs7571708 | A | G | rs7571708 | 23648065 | 2.45E-05 | Recessive model | 1.41 | [1.11-1.79] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7571708-T | Research Support, Non-U.S. Gov't |
| 2 | 236834160 | rs1962299 | A | G | rs1962299 | 23648065 | 2.45E-05 | Recessive model | 1.4 | [1.10-1.78] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1962299-T | Research Support, Non-U.S. Gov't |
| 2 | 238806370 | rs4663269 | T | C | rs4663269 | 23648065 | 7.48E-05 | Dominant model | 1.34 | [1.05-1.71] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4663269-T | Research Support, Non-U.S. Gov't |
| 2 | 240399614 | rs6726998 | A | G | rs6726998 | 23648065 | 3.31E-05 | Allelic model | 2.21 | [1.54-3.15] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6726998-C | Research Support, Non-U.S. Gov't |
| 2 | 240871893 | rs4853981 | T | C | rs4853981 | 23648065 | 7.54E-05 | Dominant model | 1.56 | [1.19-2.04] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4853981-G | Research Support, Non-U.S. Gov't |
| 2 | 241819526 | rs4675792 | C | T | rs4675792 | 23648065 | 3.45E-05 | Allelic model | 1.68 | [1.31-2.14] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4675792-C | Research Support, Non-U.S. Gov't |
| 3 | 3101065 | rs163579 | C | T | rs163579 | 23648065 | 3.07E-05 | Dominant model | 4.48 | [2.10-9.56] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs163579-G | Research Support, Non-U.S. Gov't |
| 3 | 3193676 | rs1669342 | A | G | rs1669342 | 23648065 | 8.14E-05 | Recessive model | 1.6 | [1.21-2.12] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1669342-G | Research Support, Non-U.S. Gov't |
| 3 | 3742077 | rs6796414 | A | G | rs6796414 | pha003095 | 3.05E-05 | phs000221 | phs000501 | 0.4 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6796414-G | NA |
| 3 | 5427679 | rs9842582 | A | G | rs9842582 | pha003095 | 5.56E-05 | phs000221 | phs000501 | 0.37 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9842582-G | NA |
| 3 | 5938105 | rs12233495 | C | T | rs12233495 | 23648065 | 1.19E-05 | Dominant model | 3.32 | [1.78-6.21] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12233495-G | Research Support, Non-U.S. Gov't |
| 3 | 6002693 | rs6767324 | G | A | rs6767324 | 23648065 | 1.89E-05 | Dominant model | 3.01 | [1.62-5.58] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6767324-G | Research Support, Non-U.S. Gov't |
| 3 | 6002768 | rs6807385 | T | C | rs6807385 | 23648065 | 1.89E-05 | Dominant model | 3.01 | [1.62-5.58] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6807385-A | Research Support, Non-U.S. Gov't |
| 3 | 6005401 | rs6768819 | T | C | rs6768819 | 23648065 | 2.31E-05 | Dominant model | 2.87 | [1.55-5.30] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6768819-A | Research Support, Non-U.S. Gov't |
| 3 | 7010081 | rs480409 | C | T | rs480409 | 23648065 | 9.00E-06 | Recessive model | 1.84 | [1.31-2.60] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs480409-G | Research Support, Non-U.S. Gov't |
| 3 | 7012842 | rs6796324 | G | A | rs6796324 | 23648065 | 2.86E-05 | Dominant model | 2.54 | [1.62-3.98] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6796324-A | Research Support, Non-U.S. Gov't |
| 3 | 7083814 | rs1353832 | C | T | rs1353832 | 23648065 | 3.99E-05 | Allelic model | 2.22 | [1.53-3.21] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1353832-C | Research Support, Non-U.S. Gov't |
| 3 | 7152640 | rs9876724 | G | A | rs9876724 | 23648065 | 4.97E-05 | Dominant model | 1.35 | [1.14-1.60] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9876724-G | Research Support, Non-U.S. Gov't |
| 3 | 7170011 | rs6766686 | A | G | rs6766686 | 23648065 | 6.90E-05 | Recessive model | 1.36 | [1.02-1.81] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6766686-T | Research Support, Non-U.S. Gov't |
| 3 | 7505487 | rs1868616 | A | G | rs1868616 | 23648065 | 7.77E-05 | Dominant model | 2.09 | [1.35-3.23] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1868616-A | Research Support, Non-U.S. Gov't |
| 3 | 7898720 | rs13323237 | C | T | rs13323237 | 23648065 | 9.94E-05 | Dominant model | 1.61 | [1.22-2.13] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13323237-G | Research Support, Non-U.S. Gov't |
| 3 | 10258493 | rs2302862 | T | C | rs2302862 | 23648065 | 3.42E-05 | Dominant model | 4.91 | [2.23-10.80] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2302862-A | Research Support, Non-U.S. Gov't |
| 3 | 13866499 | rs4685039 | G | A | rs4685039 | 23648065 | 6.97E-05 | Dominant model | 1.76 | [1.22-2.54] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4685039-T | Research Support, Non-U.S. Gov't |
| 3 | 14345707 | rs9883639 | C | T | rs9883639 | 23648065 | 6.96E-05 | Allelic model | 1.73 | [1.32-2.25] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9883639-C | Research Support, Non-U.S. Gov't |
| 3 | 16169491 | rs7624406 | A | G | rs7624406 | 23648065 | 2.74E-05 | Dominant model | 1.95 | [1.39-2.72] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7624406-G | Research Support, Non-U.S. Gov't |
| 3 | 16196224 | rs6775152 | G | A | rs6775152 | 23648065 | 2.21E-05 | Allelic model | 1.66 | [1.31-2.09] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6775152-T | Research Support, Non-U.S. Gov't |
| 3 | 16196224 | rs6775152 | G | A | rs6775152 | 23648065 | 4.36E-05 | Allelic model | 1.44 | [1.21-1.72] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6775152-T | Research Support, Non-U.S. Gov't |
| 3 | 17002619 | rs6769249 | G | A | rs6769249 | pha003095 | 3.55E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6769249-A | NA |
| 3 | 21361784 | rs13059346 | T | C | rs13059346 | 23648065 | 2.59E-05 | Dominant model | 4.22 | [2.06-8.63] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13059346-G | Research Support, Non-U.S. Gov't |
| 3 | 24173744 | rs1705734 | A | G | rs1705734 | 23648065 | 8.66E-05 | Allelic model | 2.12 | [1.47-3.06] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1705734-T | Research Support, Non-U.S. Gov't |
| 3 | 24267140 | rs826223 | A | G | rs826223 | 23648065 | 4.76E-05 | Dominant model | 1.31 | [1.10-1.57] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs826223-T | Research Support, Non-U.S. Gov't |
| 3 | 25383258 | rs4681047 | A | G | rs4681047 | 23648065 | 5.06E-05 | Allelic model | 2.29 | [1.54-3.38] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4681047-G | Research Support, Non-U.S. Gov't |
| 3 | 32125010 | rs7643045 | G | A | rs7643045 | 23648065 | 1.98E-05 | Recessive model | 1.32 | [1.10-1.57] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7643045-G | Research Support, Non-U.S. Gov't |
| 3 | 40174858 | rs9878321 | A | G | rs9878321 | 23648065 | 7.15E-05 | Allelic model | 1.84 | [1.36-2.48] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9878321-A | Research Support, Non-U.S. Gov't |
| 3 | 45623774 | rs1021124 | G | A | rs1021124 | pha003095 | 3.41E-05 | phs000221 | phs000501 | 0.04 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1021124-T | NA |
| 3 | 55231799 | rs1381389 | G | A | rs1381389 | 23648065 | 8.45E-05 | Recessive model | 3.5 | [1.87-6.54] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1381389-T | Research Support, Non-U.S. Gov't |
| 3 | 55236699 | rs12491607 | C | A,G,T | rs12491607 | 23648065 | 5.10E-05 | Allelic model | 3.52 | [1.91-6.49] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12491607-A | Research Support, Non-U.S. Gov't |
| 3 | 55237738 | rs10510777 | C | T | rs10510777 | 23648065 | 3.06E-05 | Recessive model | 3.69 | [1.98-6.88] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10510777-A | Research Support, Non-U.S. Gov't |
| 3 | 55241137 | rs6802697 | T | C | rs6802697 | 23648065 | 5.14E-05 | Allelic model | 3.68 | [1.97-6.89] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6802697-A | Research Support, Non-U.S. Gov't |
| 3 | 55256432 | rs374563 | C | A | rs374563 | 23648065 | 4.97E-05 | Allelic model | 3.63 | [1.92-6.84] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs374563-A | Research Support, Non-U.S. Gov't |
| 3 | 55263442 | rs535157 | A | C | rs535157 | 23648065 | 2.73E-05 | Allelic model | 3.76 | [2.02-7.00] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs535157-T | Research Support, Non-U.S. Gov't |
| 3 | 55265674 | rs393836 | A | C | rs393836 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs393836-C | Research Support, Non-U.S. Gov't |
| 3 | 58025903 | rs1718481 | C | T | rs1718481 | 23648065 | 1.67E-05 | Recessive model | 1.67 | [1.29-2.14] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1718481-T | Research Support, Non-U.S. Gov't |
| 3 | 58025903 | rs1718481 | C | T | rs1718481 | 23648065 | 7.53E-05 | Allelic model | 2.02 | [1.43-2.84] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1718481-T | Research Support, Non-U.S. Gov't |
| 3 | 58027197 | rs1623879 | A | G | rs1623879 | 23648065 | 4.00E-06 | Recessive model | 1.67 | [1.30-2.15] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1623879-G | Research Support, Non-U.S. Gov't |
| 3 | 58036792 | rs839230 | C | T | rs839230 | 23648065 | 2.60E-05 | Recessive model | 1.66 | [1.29-2.13] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs839230-T | Research Support, Non-U.S. Gov't |
| 3 | 58036792 | rs839230 | C | T | rs839230 | 23648065 | 5.97E-05 | Allelic model | 2 | [1.42-2.81] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs839230-T | Research Support, Non-U.S. Gov't |
| 3 | 58045538 | rs1249968 | C | T | rs1249968 | 23648065 | 2.37E-05 | Recessive model | 1.55 | [1.21-1.98] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1249968-T | Research Support, Non-U.S. Gov't |
| 3 | 58045538 | rs1249968 | C | T | rs1249968 | 23648065 | 6.52E-05 | Allelic model | 2.02 | [1.43-2.84] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1249968-T | Research Support, Non-U.S. Gov't |
| 3 | 64009102 | rs35836 | G | T | rs35836 | 23648065 | 9.56E-05 | Dominant model | 3.71 | [1.86-7.42] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs35836-A | Research Support, Non-U.S. Gov't |
| 3 | 66525963 | rs3845905 | T | C | rs3845905 | 23648065 | 4.00E-06 | Allelic model | 1.89 | [1.43-2.50] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3845905-G | Research Support, Non-U.S. Gov't |
| 3 | 66525963 | rs3845905 | T | C | rs3845905 | 23648065 | 6.00E-06 | Allelic model | 2.43 | [1.65-3.60] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3845905-G | Research Support, Non-U.S. Gov't |
| 3 | 68995937 | rs6787753 | C | A | rs6787753 | pha003095 | 2.55E-05 | phs000221 | phs000501 | 0.32 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6787753-A | NA |
| 3 | 69001402 | rs6785239 | A | G | rs6785239 | pha003095 | 2.96E-05 | phs000221 | phs000501 | 0.32 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6785239-G | NA |
| 3 | 69034385 | rs2033773 | G | T | rs2033773 | 23648065 | 7.42E-05 | Dominant model | 2.01 | [1.39-2.91] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2033773-C | Research Support, Non-U.S. Gov't |
| 3 | 69694906 | rs17006293 | C | T | rs17006293 | 23648065 | 9.38E-05 | Allelic model | 1.76 | [1.33-2.34] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17006293-C | Research Support, Non-U.S. Gov't |
| 3 | 71737107 | rs3796226 | A | G | rs3796226 | 23648065 | 4.64E-05 | Allelic model | 1.81 | [1.36-2.41] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3796226-C | Research Support, Non-U.S. Gov't |
| 3 | 76806018 | rs7609557 | A | G | rs7609557 | 23648065 | 8.15E-05 | Recessive model | 2 | [1.28-3.12] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7609557-C | Research Support, Non-U.S. Gov't |
| 3 | 76850916 | rs1167035 | C | T | rs1167035 | 23648065 | 4.48E-05 | Recessive model | 1.95 | [1.25-3.04] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1167035-T | Research Support, Non-U.S. Gov't |
| 3 | 77643174 | rs775723 | G | T | rs775723 | 23648065 | 6.94E-05 | Allelic model | 2.42 | [1.57-3.73] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs775723-T | Research Support, Non-U.S. Gov't |
| 3 | 77675638 | rs876675 | C | T | rs876675 | 23648065 | 3.96E-05 | Allelic model | 2.53 | [1.64-3.91] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs876675-A | Research Support, Non-U.S. Gov't |
| 3 | 77675638 | rs876675 | C | T | rs876675 | 23648065 | 4.86E-05 | Allelic model | 2.09 | [1.47-2.97] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs876675-A | Research Support, Non-U.S. Gov't |
| 3 | 87274437 | rs904115 | T | G | rs904115 | 23648065 | 5.93E-05 | Allelic model | 2.53 | [1.62-3.96] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs904115-A | Research Support, Non-U.S. Gov't |
| 3 | 87373894 | rs4859055 | C | T | rs4859055 | 23648065 | 4.91E-05 | Allelic model | 4.66 | [2.24-9.72] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4859055-G | Research Support, Non-U.S. Gov't |
| 3 | 87373894 | rs4859055 | C | T | rs4859055 | 23648065 | 7.24E-05 | Allelic model | 3.39 | [1.85-6.22] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4859055-G | Research Support, Non-U.S. Gov't |
| 3 | 95617191 | rs980856 | A | G | rs980856 | 23648065 | 3.85E-05 | Allelic model | 1.84 | [1.36-2.49] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs980856-C | Research Support, Non-U.S. Gov't |
| 3 | 106089227 | rs9831569 | C | T | rs9831569 | 23648065 | 5.35E-05 | Recessive model | 1.63 | [1.28-2.09] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9831569-A | Research Support, Non-U.S. Gov't |
| 3 | 107003691 | rs16853338 | G | A | rs16853338 | 23648065 | 3.90E-05 | Dominant model | 1.35 | [1.14-1.60] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16853338-T | Research Support, Non-U.S. Gov't |
| 3 | 107019713 | rs809421 | A | G | rs809421 | 23648065 | 8.71E-05 | Dominant model | 1.31 | [1.10-1.56] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs809421-C | Research Support, Non-U.S. Gov't |
| 3 | 109927376 | rs13323983 | A | G | rs13323983 | 21507922 | 5.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 3 | 122128394 | rs1127343 | G | A | rs1127343 | 23648065 | 5.48E-05 | Allelic model | 2.17 | [1.47-3.23] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1127343-A | Research Support, Non-U.S. Gov't |
| 3 | 124499685 | rs3772827 | C | T | rs3772827 | 23648065 | 4.05E-05 | Allelic model | 2.82 | [1.75-4.54] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3772827-A | Research Support, Non-U.S. Gov't |
| 3 | 124515395 | rs2291086 | G | A | rs2291086 | 23648065 | 6.71E-05 | Allelic model | 2.65 | [1.66-4.23] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2291086-T | Research Support, Non-U.S. Gov't |
| 3 | 124515636 | rs2291089 | C | T | rs2291089 | 23648065 | 3.18E-05 | Allelic model | 2.78 | [1.73-4.45] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2291089-A | Research Support, Non-U.S. Gov't |
| 3 | 124545750 | rs6771896 | G | A | rs6771896 | 23648065 | 4.21E-05 | Allelic model | 2.53 | [1.59-4.03] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6771896-C | Research Support, Non-U.S. Gov't |
| 3 | 124546047 | rs4677946 | A | G | rs4677946 | 23648065 | 6.17E-05 | Allelic model | 2.59 | [1.60-4.21] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4677946-A | Research Support, Non-U.S. Gov't |
| 3 | 124550364 | rs3772840 | C | T | rs3772840 | 23648065 | 8.52E-05 | Allelic model | 2.32 | [1.51-3.56] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3772840-A | Research Support, Non-U.S. Gov't |
| 3 | 124610238 | rs7373878 | G | T | rs7373878 | 23648065 | 1.50E-05 | Allelic model | 2.7 | [1.68-4.36] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7373878-A | Research Support, Non-U.S. Gov't |
| 3 | 128478542 | rs9831813 | G | A | rs9831813 | pha003095 | 5.45E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9831813-A | NA |
| 3 | 128516142 | rs3772158 | A | C | rs3772158 | pha003095 | 7.66E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3772158-C | NA |
| 3 | 128528630 | rs9853945 | A | G | rs9853945 | pha003095 | 6.76E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9853945-G | NA |
| 3 | 131813900 | rs6775745 | G | A | rs6775745 | 21507922 | 2.00E-07 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 3 | 144559115 | rs1401033 | C | T | rs1401033 | pha003095 | 8.41E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1401033-T | NA |
| 3 | 145921954 | rs9839874 | T | C | rs9839874 | 23648065 | 9.58E-05 | Allelic model | 1.58 | [1.26-1.99] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9839874-T | Research Support, Non-U.S. Gov't |
| 3 | 146394094 | rs10935638 | C | T | rs10935638 | 23648065 | 1.75E-05 | Recessive model | 2.12 | [1.36-3.30] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10935638-A | Research Support, Non-U.S. Gov't |
| 3 | 151155620 | rs6781302 | G | A | rs6781302 | pha003095 | 9.57E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6781302-G | NA |
| 3 | 156821808 | rs6441111 | C | T | rs6441111 | 23648065 | 5.58E-05 | Dominant model | 1.21 | [1.01-1.45] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6441111-T | Research Support, Non-U.S. Gov't |
| 3 | 157054271 | rs988587 | T | G | rs988587 | 23648065 | 1.79E-05 | Allelic model | 1.76 | [1.35-2.29] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs988587-C | Research Support, Non-U.S. Gov't |
| 3 | 157054271 | rs988587 | T | G | rs988587 | 23648065 | 6.74E-05 | Allelic model | 2.11 | [1.46-3.05] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs988587-C | Research Support, Non-U.S. Gov't |
| 3 | 157088982 | rs9883103 | C | T | rs9883103 | 23648065 | 8.25E-05 | Allelic model | 1.58 | NA | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9883103-A | Research Support, Non-U.S. Gov't |
| 3 | 157094479 | rs4680360 | T | C | rs4680360 | 23648065 | 4.26E-05 | Allelic model | 1.71 | [1.32-2.22] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4680360-C | Research Support, Non-U.S. Gov't |
| 3 | 157113276 | rs12486427 | A | C | rs12486427 | 23648065 | 2.64E-05 | Allelic model | 1.73 | [1.33-2.24] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12486427-G | Research Support, Non-U.S. Gov't |
| 3 | 157125584 | rs6803628 | G | A | rs6803628 | 23648065 | 2.85E-05 | Allelic model | 1.69 | [1.32-2.18] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6803628-A | Research Support, Non-U.S. Gov't |
| 3 | 157166123 | rs4680367 | G | A | rs4680367 | 23648065 | 1.68E-05 | Allelic model | 1.77 | [1.36-2.31] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4680367-T | Research Support, Non-U.S. Gov't |
| 3 | 159714802 | rs2243143 | G | A | rs2243143 | 23648065 | 6.19E-05 | Recessive model | 1.22 | [0.96-1.55] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2243143-C | Research Support, Non-U.S. Gov't |
| 3 | 159718268 | rs6441284 | A | G | rs6441284 | 23648065 | 6.19E-05 | Recessive model | 1.19 | [0.94-1.51] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6441284-A | Research Support, Non-U.S. Gov't |
| 3 | 161460016 | rs16833312 | C | T | rs16833312 | 23648065 | 2.00E-05 | Dominant model | 5.18 | [2.23-12.02] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16833312-G | Research Support, Non-U.S. Gov't |
| 3 | 161490079 | rs1515730 | G | A | rs1515730 | 23648065 | 3.57E-05 | Allelic model | 3.69 | [1.89-7.21] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1515730-G | Research Support, Non-U.S. Gov't |
| 3 | 168644514 | rs6768780 | C | A | rs6768780 | 23648065 | 5.68E-05 | Dominant model | 3.04 | [1.77-5.22] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6768780-T | Research Support, Non-U.S. Gov't |
| 3 | 174038312 | rs13098004 | C | A | rs13098004 | 23648065 | 2.90E-05 | Allelic model | 1.99 | [1.44-2.75] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13098004-C | Research Support, Non-U.S. Gov't |
| 3 | 178357197 | rs9847335 | A | G | rs9847335 | 23648065 | 1.86E-05 | Dominant model | 3.11 | [1.73-5.60] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9847335-T | Research Support, Non-U.S. Gov't |
| 3 | 178365840 | rs7615444 | A | C | rs7615444 | 23648065 | 5.83E-05 | Allelic model | 2.82 | [1.71-4.65] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7615444-T | Research Support, Non-U.S. Gov't |
| 3 | 178449906 | rs6443571 | G | A | rs6443571 | 23648065 | 1.89E-05 | Allelic model | 2.9 | [1.78-4.71] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6443571-G | Research Support, Non-U.S. Gov't |
| 3 | 181340141 | rs13086529 | A | G | rs13086529 | 23648065 | 6.31E-05 | Recessive model | 1.34 | [1.00-1.79] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13086529-C | Research Support, Non-U.S. Gov't |
| 3 | 187710426 | rs9860469 | A | G | rs9860469 | 23648065 | 5.70E-05 | Recessive model | 1.51 | [1.07-2.13] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9860469-C | Research Support, Non-U.S. Gov't |
| 3 | 187716886 | rs1553091 | A | G | rs1553091 | 23648065 | 7.00E-06 | Recessive model | 1.48 | [1.05-2.08] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1553091-G | Research Support, Non-U.S. Gov't |
| 3 | 187719473 | rs9843063 | G | A | rs9843063 | 23648065 | 5.70E-05 | Recessive model | 1.49 | [1.05-2.11] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9843063-A | Research Support, Non-U.S. Gov't |
| 3 | 187727515 | rs11924318 | G | A | rs11924318 | 23648065 | 7.12E-05 | Recessive model | 1.46 | [1.04-2.07] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11924318-T | Research Support, Non-U.S. Gov't |
| 3 | 192562429 | rs9870609 | A | G | rs9870609 | 23648065 | 3.83E-05 | Recessive model | 1.33 | [1.11-1.59] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9870609-G | Research Support, Non-U.S. Gov't |
| 3 | 194000979 | rs9862745 | C | T | rs9862745 | 23648065 | 5.74E-05 | Allelic model | 1.6 | [1.27-2.01] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9862745-T | Research Support, Non-U.S. Gov't |
| 3 | 196369163 | rs76036994 | GA | G | rs843522 | 23648065 | 5.04E-05 | Dominant model | 1.58 | [1.22-2.03] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs843522-G | Research Support, Non-U.S. Gov't |
| 3 | 196369163 | rs843522 | G | A | rs843522 | 23648065 | 5.04E-05 | Dominant model | 1.58 | [1.22-2.03] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs843522-G | Research Support, Non-U.S. Gov't |
| 4 | 4333387 | rs6855893 | T | C | rs6855893 | 23648065 | 6.13E-05 | Recessive model | 1.58 | [1.19-2.10] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6855893-G | Research Support, Non-U.S. Gov't |
| 4 | 6065298 | rs17766228 | T | C | rs17766228 | 23648065 | 8.44E-05 | Recessive model | 1.63 | [1.16-2.30] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17766228-A | Research Support, Non-U.S. Gov't |
| 4 | 6116456 | rs11930138 | A | G | rs11930138 | pha003095 | 4.13E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11930138-G | NA |
| 4 | 6367467 | rs6831971 | T | C | rs6831971 | 23648065 | 7.66E-05 | Recessive model | 1.28 | [1.07-1.53] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6831971-G | Research Support, Non-U.S. Gov't |
| 4 | 7262170 | rs904989 | C | T | rs904989 | 23648065 | 8.39E-05 | Recessive model | 1.27 | [1.07-1.52] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs904989-G | Research Support, Non-U.S. Gov't |
| 4 | 10883658 | rs1483660 | T | C | rs1483660 | 23648065 | 1.31E-05 | Recessive model | 1.35 | [1.13-1.61] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1483660-G | Research Support, Non-U.S. Gov't |
| 4 | 31718284 | rs10489008 | A | C | rs10489008 | 23648065 | 4.30E-05 | Recessive model | 2.14 | [1.33-3.45] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10489008-A | Research Support, Non-U.S. Gov't |
| 4 | 36021619 | rs872322 | G | A | rs872322 | 23648065 | 1.40E-05 | Allelic model | 2.63 | [1.63-4.26] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs872322-A | Research Support, Non-U.S. Gov't |
| 4 | 36021619 | rs872322 | G | A | rs872322 | 23648065 | 2.12E-05 | Allelic model | 1.96 | [1.41-2.73] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs872322-A | Research Support, Non-U.S. Gov't |
| 4 | 36026747 | rs1567482 | T | C | rs1567482 | 23648065 | 6.00E-06 | Allelic model | 2.85 | [1.72-4.72] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1567482-G | Research Support, Non-U.S. Gov't |
| 4 | 46898265 | rs7683552 | T | C | rs7683552 | 23648065 | 5.82E-05 | Allelic model | 2.01 | [1.43-2.82] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7683552-C | Research Support, Non-U.S. Gov't |
| 4 | 46941018 | rs1028005 | A | G | rs1028005 | 23648065 | 8.56E-05 | Allelic model | 1.98 | [1.41-2.78] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1028005-G | Research Support, Non-U.S. Gov't |
| 4 | 52798624 | rs1996617 | T | C | rs1996617 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1996617-A | Research Support, Non-U.S. Gov't |
| 4 | 52810307 | rs6829655 | T | C | rs6829655 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6829655-T | Research Support, Non-U.S. Gov't |
| 4 | 52830444 | rs11735705 | T | G | rs11735705 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11735705-T | Research Support, Non-U.S. Gov't |
| 4 | 52860156 | rs1519588 | C | T | rs1519588 | 23648065 | 4.82E-05 | Allelic model | 3.66 | [1.95-6.86] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1519588-G | Research Support, Non-U.S. Gov't |
| 4 | 52867437 | rs7695726 | A | C | rs7695726 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7695726-A | Research Support, Non-U.S. Gov't |
| 4 | 52871894 | rs4610396 | G | T | rs4610396 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4610396-C | Research Support, Non-U.S. Gov't |
| 4 | 52888026 | rs170424 | A | C | rs170424 | 23648065 | 8.87E-05 | Allelic model | 3.52 | [1.88-6.61] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs170424-C | Research Support, Non-U.S. Gov't |
| 4 | 55913934 | rs7441352 | A | G | rs7441352 | 23648065 | 5.78E-05 | Allelic model | 1.67 | [1.30-2.13] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7441352-A | Research Support, Non-U.S. Gov't |
| 4 | 57300557 | rs1520026 | C | T | rs1520026 | 23648065 | 5.21E-05 | Allelic model | 1.43 | [1.21-1.71] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1520026-T | Research Support, Non-U.S. Gov't |
| 4 | 62240526 | rs6858223 | A | G | rs6858223 | 23648065 | 1.39E-05 | Allelic model | 1.65 | [1.32-2.06] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6858223-G | Research Support, Non-U.S. Gov't |
| 4 | 63407579 | rs2168267 | C | T | rs2168267 | 23648065 | 5.48E-05 | Allelic model | 1.8 | [1.35-2.40] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2168267-A | Research Support, Non-U.S. Gov't |
| 4 | 63424089 | rs11944965 | C | T | rs11944965 | 23648065 | 2.00E-06 | Dominant model | 1.99 | [1.48-2.68] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11944965-T | Research Support, Non-U.S. Gov't |
| 4 | 64337600 | rs2090189 | C | T | rs2090189 | pha003095 | 7.97E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2090189-T | NA |
| 4 | 82133264 | rs989445 | C | A | rs989445 | 23648065 | 3.88E-05 | Dominant model | 3.84 | [1.93-7.63] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs989445-C | Research Support, Non-U.S. Gov't |
| 4 | 82616045 | rs6535273 | T | C | rs6535273 | 23648065 | 2.80E-05 | Recessive model | 1.29 | [1.08-1.54] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6535273-A | Research Support, Non-U.S. Gov't |
| 4 | 85205214 | rs1495151 | G | A | rs1495151 | 23648065 | 9.46E-05 | Allelic model | 1.69 | [1.30-2.19] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1495151-A | Research Support, Non-U.S. Gov't |
| 4 | 87473776 | rs4478147 | G | A | rs4478147 | 23648065 | 4.00E-05 | Dominant model | 1.51 | [1.18-1.93] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4478147-G | Research Support, Non-U.S. Gov't |
| 4 | 91253355 | rs10015182 | C | T | rs10015182 | 23648065 | 1.75E-05 | Recessive model | 1.3 | [1.09-1.55] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10015182-T | Research Support, Non-U.S. Gov't |
| 4 | 96300827 | rs10222858 | T | C | rs10222858 | pha003095 | 5.37E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10222858-C | NA |
| 4 | 96311257 | rs10440376 | A | G | rs10440376 | pha003095 | 3.05E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10440376-G | NA |
| 4 | 99459528 | rs2037832 | C | T | rs2037832 | 23648065 | 9.50E-05 | Recessive model | 1.68 | [1.16-2.42] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2037832-G | Research Support, Non-U.S. Gov't |
| 4 | 99485507 | rs17801290 | T | C | rs17801290 | pha003095 | 4.05E-05 | phs000221 | phs000501 | 0.42 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17801290-C | NA |
| 4 | 104545224 | rs3796974 | T | C | rs3796974 | 23648065 | 1.73E-05 | Allelic model | 1.76 | [1.36-2.28] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3796974-A | Research Support, Non-U.S. Gov't |
| 4 | 104552687 | rs12641703 | G | A | rs12641703 | 23648065 | 3.02E-05 | Allelic model | 1.74 | [1.35-2.25] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12641703-C | Research Support, Non-U.S. Gov't |
| 4 | 105921314 | rs12500787 | G | T | rs12500787 | 23648065 | 3.28E-05 | Allelic model | 3.64 | [1.89-7.00] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12500787-T | Research Support, Non-U.S. Gov't |
| 4 | 112557798 | rs983966 | G | A | rs983966 | 23648065 | 5.34E-05 | Dominant model | 1.92 | [1.30-2.83] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs983966-T | Research Support, Non-U.S. Gov't |
| 4 | 112588951 | rs1450781 | T | C | rs1450781 | 23648065 | 1.93E-05 | Dominant model | 2 | [1.35-2.95] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1450781-G | Research Support, Non-U.S. Gov't |
| 4 | 113328078 | rs6838440 | C | T | rs6838440 | 21799462 | 3.00E-06 | NA | 2.1 | [1.49-2.96] | 67 Japanese ancestry cases; 203 Japanese ancestry controls | Japanese(270) | ALL(270) | ASN(270) | ALL(270) | Epirubicin-induced leukopenia | HPOID:0001882 | Leukopenia | DOID:615 | leukopenia | D007970 | Leukopenia | EFOID:0004233 | leukopenia | Leukopenia | rs6838440-C | Research Support, Non-U.S. Gov't | C | ALPK1 |
| 4 | 118651823 | rs4422476 | T | C | rs4422476 | 21507922 | 8.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 4 | 120756608 | rs17363983 | T | G | rs17363983 | 23648065 | 2.56E-05 | Recessive model | 1.5 | [1.19-1.91] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17363983-C | Research Support, Non-U.S. Gov't |
| 4 | 120760872 | rs7688177 | T | C | rs7688177 | 23648065 | 2.72E-05 | Allelic model | 1.86 | [1.40-2.48] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7688177-C | Research Support, Non-U.S. Gov't |
| 4 | 125298963 | rs1159819 | G | A | rs1159819 | 23648065 | 9.20E-05 | Allelic model | 1.52 | [1.23-1.89] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1159819-T | Research Support, Non-U.S. Gov't |
| 4 | 125320611 | rs17008117 | C | T | rs17008117 | 23648065 | 9.20E-05 | Allelic model | 1.52 | [1.23-1.89] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17008117-G | Research Support, Non-U.S. Gov't |
| 4 | 130185974 | rs9994767 | C | T | rs9994767 | 23648065 | 4.62E-05 | Recessive model | 1.38 | [1.09-1.75] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9994767-C | Research Support, Non-U.S. Gov't |
| 4 | 130375150 | rs1433384 | T | C | rs1433384 | 23648065 | 1.33E-05 | Allelic model | 1.52 | [1.26-1.83] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1433384-C | Research Support, Non-U.S. Gov't |
| 4 | 130731072 | rs2391504 | A | G | rs2391504 | 23648065 | 5.68E-05 | Dominant model | 1.91 | [1.40-2.61] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2391504-T | Research Support, Non-U.S. Gov't |
| 4 | 130767230 | rs10028795 | G | A | rs10028795 | 23648065 | 6.09E-05 | Recessive model | 1.31 | [1.10-1.56] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10028795-G | Research Support, Non-U.S. Gov't |
| 4 | 130767899 | rs17050689 | T | C | rs17050689 | 23648065 | 6.09E-05 | Recessive model | 1.31 | [1.10-1.56] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17050689-T | Research Support, Non-U.S. Gov't |
| 4 | 131238094 | rs1022079 | C | A | rs1022079 | 23648065 | 6.10E-05 | Allelic model | 1.88 | [1.39-2.55] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1022079-A | Research Support, Non-U.S. Gov't |
| 4 | 133858930 | rs11099230 | A | G | rs11099230 | 23648065 | 2.05E-05 | Dominant model | 1.79 | [1.30-2.47] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11099230-G | Research Support, Non-U.S. Gov't |
| 4 | 133862954 | rs12641896 | A | G | rs12641896 | 23648065 | 3.23E-05 | Dominant model | 1.67 | [1.25-2.25] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12641896-C | Research Support, Non-U.S. Gov't |
| 4 | 137953807 | rs515800 | T | C | rs515800 | 23648065 | 7.32E-05 | Dominant model | 1.51 | [1.16-1.98] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs515800-T | Research Support, Non-U.S. Gov't |
| 4 | 138161364 | rs4561979 | T | C | rs4561979 | 23648065 | 5.08E-05 | Dominant model | 1.65 | [1.27-2.14] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4561979-T | Research Support, Non-U.S. Gov't |
| 4 | 138367052 | rs7698992 | T | C | rs7698992 | 23648065 | 3.39E-05 | Dominant model | 1.99 | [1.36-2.90] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7698992-T | Research Support, Non-U.S. Gov't |
| 4 | 138369786 | rs10519425 | G | A | rs10519425 | 23648065 | 3.39E-05 | Dominant model | 1.99 | [1.36-2.90] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10519425-G | Research Support, Non-U.S. Gov't |
| 4 | 139336708 | rs2976499 | C | T | rs2976499 | 23648065 | 8.38E-05 | Dominant model | 1.59 | [1.12-2.25] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2976499-G | Research Support, Non-U.S. Gov't |
| 4 | 139336851 | rs11732157 | C | T | rs11732157 | 23648065 | 8.88E-05 | Dominant model | 1.79 | [1.22-2.63] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11732157-G | Research Support, Non-U.S. Gov't |
| 4 | 139494811 | rs1376086 | A | G | rs1376086 | 23648065 | 7.91E-05 | Dominant model | 1.52 | [1.19-1.93] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1376086-C | Research Support, Non-U.S. Gov't |
| 4 | 140497312 | rs11726931 | T | C | rs11726931 | 23648065 | 9.06E-05 | Allelic model | 2.54 | [1.56-4.12] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11726931-A | Research Support, Non-U.S. Gov't |
| 4 | 142792211 | rs17015119 | G | A | rs17015119 | 23648065 | 8.53E-05 | Dominant model | 1.33 | [1.06-1.67] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17015119-T | Research Support, Non-U.S. Gov't |
| 4 | 146867376 | rs6537382 | C | A | rs6537382 | 23648065 | 2.37E-05 | Allelic model | 2.28 | [1.56-3.32] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6537382-C | Research Support, Non-U.S. Gov't |
| 4 | 153879878 | rs11737767 | C | T | rs11737767 | 23648065 | 3.33E-05 | Recessive model | 1.61 | [1.28-2.03] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11737767-T | Research Support, Non-U.S. Gov't |
| 4 | 154369706 | rs13105829 | C | T | rs13105829 | 23648065 | 3.62E-05 | Allelic model | 1.48 | [1.23-1.78] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13105829-T | Research Support, Non-U.S. Gov't |
| 4 | 154369706 | rs13105829 | C | T | rs13105829 | 23648065 | 8.34E-05 | Allelic model | 1.46 | [1.21-1.76] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13105829-T | Research Support, Non-U.S. Gov't |
| 4 | 154371229 | rs11941933 | C | T | rs11941933 | 23648065 | 3.03E-05 | Allelic model | 1.48 | [1.23-1.79] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11941933-A | Research Support, Non-U.S. Gov't |
| 4 | 154371229 | rs11941933 | C | T | rs11941933 | 23648065 | 6.86E-05 | Allelic model | 1.47 | [1.22-1.77] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11941933-A | Research Support, Non-U.S. Gov't |
| 4 | 154373196 | rs11728644 | G | A | rs11728644 | 23648065 | 2.06E-05 | Allelic model | 1.5 | [1.25-1.80] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11728644-A | Research Support, Non-U.S. Gov't |
| 4 | 154373196 | rs11728644 | G | A | rs11728644 | 23648065 | 2.55E-05 | Allelic model | 1.5 | [1.24-1.80] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11728644-A | Research Support, Non-U.S. Gov't |
| 4 | 154374984 | rs6817170 | T | C | rs6817170 | 23648065 | 9.00E-06 | Allelic model | 1.52 | [1.26-1.82] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6817170-G | Research Support, Non-U.S. Gov't |
| 4 | 154376222 | rs11732163 | G | A | rs11732163 | 23648065 | 1.35E-05 | Allelic model | 1.51 | [1.26-1.81] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11732163-T | Research Support, Non-U.S. Gov't |
| 4 | 154376222 | rs11732163 | G | A | rs11732163 | 23648065 | 2.66E-05 | Allelic model | 1.48 | [1.24-1.78] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11732163-T | Research Support, Non-U.S. Gov't |
| 4 | 154378572 | rs1560940 | A | G | rs1560940 | 23648065 | 2.67E-05 | Allelic model | 1.49 | [1.24-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1560940-C | Research Support, Non-U.S. Gov't |
| 4 | 154389653 | rs1836401 | A | G | rs1836401 | 23648065 | 2.36E-05 | Allelic model | 1.49 | [1.24-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1836401-C | Research Support, Non-U.S. Gov't |
| 4 | 154389653 | rs1836401 | A | G | rs1836401 | 23648065 | 3.87E-05 | Allelic model | 1.47 | [1.23-1.77] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1836401-C | Research Support, Non-U.S. Gov't |
| 4 | 154408454 | rs713248 | A | G | rs713248 | 23648065 | 1.63E-05 | Allelic model | 1.5 | [1.25-1.79] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs713248-C | Research Support, Non-U.S. Gov't |
| 4 | 154408454 | rs713248 | A | G | rs713248 | 23648065 | 1.92E-05 | Allelic model | 1.49 | [1.25-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs713248-C | Research Support, Non-U.S. Gov't |
| 4 | 156311510 | rs7663620 | G | A | rs7663620 | 23648065 | 7.77E-05 | Dominant model | 1.81 | [1.31-2.49] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7663620-A | Research Support, Non-U.S. Gov't |
| 4 | 156322989 | rs11100000 | C | T | rs11100000 | 23648065 | 4.59E-05 | Dominant model | 1.85 | [1.33-2.58] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11100000-A | Research Support, Non-U.S. Gov't |
| 4 | 157683685 | rs1425486 | C | T | rs1425486 | 23648065 | 7.87E-05 | Recessive model | 3.77 | [1.95-7.29] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1425486-C | Research Support, Non-U.S. Gov't |
| 4 | 162953565 | rs1471693 | G | A | rs1471693 | 23648065 | 3.64E-05 | Allelic model | 1.85 | [1.38-2.49] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1471693-G | Research Support, Non-U.S. Gov't |
| 4 | 162985367 | rs1492457 | G | A | rs1492457 | 23648065 | 3.68E-05 | Dominant model | 1.66 | [1.30-2.11] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1492457-T | Research Support, Non-U.S. Gov't |
| 4 | 162992246 | rs2086754 | A | C | rs2086754 | 23648065 | 5.58E-05 | Dominant model | 1.62 | [1.28-2.05] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2086754-C | Research Support, Non-U.S. Gov't |
| 4 | 163243053 | rs4440177 | G | A | rs4440177 | 23648065 | 4.16E-05 | Allelic model | 1.75 | [1.34-2.28] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4440177-T | Research Support, Non-U.S. Gov't |
| 4 | 170975204 | rs12650424 | T | C | rs12650424 | 23648065 | 2.35E-05 | Recessive model | 1.23 | [1.03-1.48] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12650424-C | Research Support, Non-U.S. Gov't |
| 4 | 174751009 | rs6833126 | T | C | rs6833126 | 23648065 | 9.06E-05 | Dominant model | 2 | [1.36-2.96] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6833126-A | Research Support, Non-U.S. Gov't |
| 4 | 175674144 | rs13113891 | A | G | rs13113891 | 23648065 | 9.39E-05 | Dominant model | 1.88 | [1.30-2.71] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13113891-A | Research Support, Non-U.S. Gov't |
| 4 | 178201257 | rs4690504 | C | T | rs4690504 | 23648065 | 5.07E-05 | Dominant model | 1.81 | [1.28-2.55] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4690504-G | Research Support, Non-U.S. Gov't |
| 4 | 180537212 | rs17067866 | T | C | rs17067866 | 23648065 | 6.23E-05 | Allelic model | 2.48 | [1.56-3.95] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17067866-T | Research Support, Non-U.S. Gov't |
| 4 | 181907769 | rs10016729 | A | G | rs10016729 | 23648065 | 1.40E-05 | Recessive model | 1.39 | [1.14-1.70] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10016729-T | Research Support, Non-U.S. Gov't |
| 4 | 185946538 | rs6851788 | T | C | rs6851788 | 23648065 | 7.39E-05 | Dominant model | 1.84 | [1.15-2.94] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6851788-C | Research Support, Non-U.S. Gov't |
| 4 | 186695208 | rs4487396 | C | T | rs4487396 | 23648065 | 2.76E-05 | Recessive model | 1.44 | [1.00-2.07] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4487396-C | Research Support, Non-U.S. Gov't |
| 4 | 187382294 | rs12506228 | C | A | rs12506228 | 23648065 | 2.67E-05 | Allelic model | 1.89 | [1.41-2.53] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12506228-A | Research Support, Non-U.S. Gov't |
| 4 | 187851352 | rs7657521 | C | T | rs7657521 | 23648065 | 1.49E-05 | Recessive model | 1.35 | [1.09-1.67] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7657521-C | Research Support, Non-U.S. Gov't |
| 4 | 188114879 | rs7692743 | G | A | rs7692743 | 23648065 | 2.95E-05 | Allelic model | 2.87 | [1.76-4.69] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7692743-C | Research Support, Non-U.S. Gov't |
| 4 | 189342369 | rs713507 | G | A | rs713507 | pha003095 | 6.19E-05 | phs000221 | phs000501 | 0.28 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs713507-A | NA |
| 5 | 1468287 | rs4975648 | C | A | rs4975648 | 23648065 | 9.76E-05 | Recessive model | 2.52 | [1.57-4.03] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4975648-G | Research Support, Non-U.S. Gov't |
| 5 | 1936443 | rs2129470 | C | A | rs2129470 | 23648065 | 4.56E-05 | Recessive model | 1.13 | [0.83-1.53] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2129470-C | Research Support, Non-U.S. Gov't |
| 5 | 3132559 | rs469508 | C | T | rs469508 | 23648065 | 4.22E-05 | Allelic model | 1.87 | [1.39-2.52] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs469508-T | Research Support, Non-U.S. Gov't |
| 5 | 3174785 | rs12657403 | G | A | rs12657403 | 23648065 | 9.91E-05 | Allelic model | 1.83 | [1.35-2.48] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12657403-A | Research Support, Non-U.S. Gov't |
| 5 | 5407814 | rs2964475 | T | G | rs2964475 | 23648065 | 4.00E-06 | Allelic model | 2.25 | [1.59-3.17] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2964475-C | Research Support, Non-U.S. Gov't |
| 5 | 5415012 | rs2913356 | T | C | rs2913356 | 23648065 | 4.94E-05 | Allelic model | 2.04 | [1.44-2.87] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2913356-G | Research Support, Non-U.S. Gov't |
| 5 | 13816740 | rs16902777 | G | A | rs16902777 | 23648065 | 8.38E-05 | Allelic model | 3.41 | [1.85-6.29] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16902777-G | Research Support, Non-U.S. Gov't |
| 5 | 14989823 | rs2402022 | T | C | rs2402022 | 23648065 | 6.36E-05 | Dominant model | 1.69 | [1.10-2.60] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2402022-T | Research Support, Non-U.S. Gov't |
| 5 | 16662297 | rs13537 | G | A | rs13537 | pha003095 | 7.42E-05 | phs000221 | phs000501 | 0.11 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs13537-T | NA |
| 5 | 27343904 | rs2329426 | T | C | rs2329426 | 23648065 | 5.72E-05 | Allelic model | 1.62 | [1.27-2.06] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2329426-T | Research Support, Non-U.S. Gov't |
| 5 | 27987104 | rs4537065 | G | A | rs4537065 | 23648065 | 6.50E-05 | Recessive model | 2.01 | [1.43-2.83] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4537065-A | Research Support, Non-U.S. Gov't |
| 5 | 27992491 | rs2876936 | C | T | rs2876936 | 23648065 | 6.50E-05 | Recessive model | 2.01 | [1.43-2.83] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2876936-A | Research Support, Non-U.S. Gov't |
| 5 | 28006650 | rs4398645 | T | C | rs4398645 | 23648065 | 6.50E-05 | Recessive model | 2.01 | [1.43-2.83] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4398645-G | Research Support, Non-U.S. Gov't |
| 5 | 28017229 | rs1494617 | T | C | rs1494617 | 23648065 | 6.50E-05 | Recessive model | 2.01 | [1.43-2.83] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1494617-C | Research Support, Non-U.S. Gov't |
| 5 | 31838491 | rs6874198 | A | G | rs6874198 | 23648065 | 2.81E-05 | Allelic model | 1.59 | [1.27-1.98] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6874198-A | Research Support, Non-U.S. Gov't |
| 5 | 35799994 | rs3822735 | A | G | rs3822735 | 23648065 | 2.00E-06 | Dominant model | 2.06 | [1.50-2.83] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3822735-G | Research Support, Non-U.S. Gov't |
| 5 | 38203031 | rs6451374 | G | T | rs6451374 | 23648065 | 4.22E-05 | Allelic model | 1.75 | [1.34-2.28] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6451374-T | Research Support, Non-U.S. Gov't |
| 5 | 38425008 | rs3812046 | G | A | rs3812046 | pha003095 | 5.61E-06 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3812046-A | NA |
| 5 | 40401509 | rs17234657 | T | G | rs17234657 | pha003095 | 8.82E-05 | phs000221 | phs000501 | 0.31 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17234657-G | NA |
| 5 | 40573745 | rs9292780 | T | C | rs9292780 | pha003095 | 7.42E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9292780-T | NA |
| 5 | 50391229 | rs17820197 | C | T | rs17820197 | 23648065 | 7.17E-05 | Recessive model | 1.3 | [1.04-1.62] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17820197-A | Research Support, Non-U.S. Gov't |
| 5 | 51124949 | rs7713485 | C | T | rs7713485 | 23648065 | 8.20E-05 | Recessive model | 1.43 | [0.93-2.20] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7713485-A | Research Support, Non-U.S. Gov't |
| 5 | 52003387 | rs351929 | A | C | rs351929 | 23648065 | 7.69E-05 | Allelic model | 1.59 | [1.26-1.99] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs351929-C | Research Support, Non-U.S. Gov't |
| 5 | 53969773 | rs4865859 | G | A | rs4865859 | pha003095 | 6.56E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4865859-A | NA |
| 5 | 54184663 | rs2075401 | A | C | rs2075401 | 23648065 | 8.83E-05 | Allelic model | 2.46 | [1.59-3.80] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2075401-G | Research Support, Non-U.S. Gov't |
| 5 | 58713680 | rs2547917 | G | A | rs2547917 | 23648065 | 3.00E-06 | Recessive model | 2 | [1.35-2.96] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2547917-A | Research Support, Non-U.S. Gov't |
| 5 | 58721609 | rs2607347 | T | C | rs2607347 | 23648065 | 9.97E-06 | Recessive model | 1.87 | [1.26-2.77] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2607347-G | Research Support, Non-U.S. Gov't |
| 5 | 68038077 | rs12516844 | T | G | rs12516844 | 23648065 | 3.51E-05 | Dominant model | 2.47 | [1.47-4.17] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12516844-T | Research Support, Non-U.S. Gov't |
| 5 | 72995398 | rs17552357 | C | T | rs17552357 | 23648065 | 9.89E-05 | Allelic model | 2.23 | [1.47-3.37] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17552357-T | Research Support, Non-U.S. Gov't |
| 5 | 73016810 | rs16870743 | A | G | rs16870743 | 23648065 | 1.51E-05 | Dominant model | 9.52 | [2.31-39.17] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16870743-T | Research Support, Non-U.S. Gov't |
| 5 | 75623689 | rs2913251 | A | G | rs2913251 | 23648065 | 5.19E-05 | Allelic model | 1.77 | [1.34-2.34] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2913251-T | Research Support, Non-U.S. Gov't |
| 5 | 75632745 | rs2913248 | G | A | rs2913248 | 23648065 | 2.61E-05 | Allelic model | 1.85 | [1.39-2.46] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2913248-G | Research Support, Non-U.S. Gov't |
| 5 | 75871279 | rs3756514 | G | T | rs3756514 | 23648065 | 3.68E-05 | Allelic model | 1.68 | [1.31-2.14] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3756514-T | Research Support, Non-U.S. Gov't |
| 5 | 75874655 | rs17680811 | T | C | rs17680811 | 23648065 | 4.56E-05 | Recessive model | 1.63 | [1.28-2.08] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17680811-G | Research Support, Non-U.S. Gov't |
| 5 | 75875629 | rs17748322 | T | C | rs17748322 | 23648065 | 8.46E-05 | Allelic model | 1.64 | [1.28-2.10] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17748322-C | Research Support, Non-U.S. Gov't |
| 5 | 75890020 | rs1501788 | C | T | rs1501788 | 23648065 | 5.78E-05 | Recessive model | 1.57 | [1.23-2.00] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1501788-A | Research Support, Non-U.S. Gov't |
| 5 | 78261957 | rs921945 | A | G | rs921945 | pha003095 | 8.72E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs921945-G | NA |
| 5 | 78282670 | rs163125 | G | A | rs163125 | pha003095 | 9.24E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs163125-G | NA |
| 5 | 79401417 | rs421837 | T | C | rs421837 | 23648065 | 2.28E-05 | Dominant model | 1.98 | [1.41-2.80] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs421837-T | Research Support, Non-U.S. Gov't |
| 5 | 79888450 | rs2405867 | G | A | rs2405867 | 23648065 | 2.22E-05 | Dominant model | 1.7 | [1.21-2.38] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2405867-G | Research Support, Non-U.S. Gov't |
| 5 | 79952034 | rs380691 | A | G | rs380691 | 23648065 | 5.52E-05 | Dominant model | 1.57 | [1.12-2.21] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs380691-T | Research Support, Non-U.S. Gov't |
| 5 | 79966029 | rs1805355 | G | A | rs1805355 | 23648065 | 3.04E-05 | Recessive model | 1.72 | [1.20-2.46] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1805355-G | Research Support, Non-U.S. Gov't |
| 5 | 80008704 | rs1428030 | T | C | rs1428030 | 23648065 | 4.94E-05 | Recessive model | 1.73 | [1.20-2.49] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1428030-T | Research Support, Non-U.S. Gov't |
| 5 | 80080681 | rs6151826 | A | G | rs6151826 | 23648065 | 2.47E-05 | Recessive model | 1.66 | [1.15-2.40] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6151826-T | Research Support, Non-U.S. Gov't |
| 5 | 80168005 | rs16878204 | T | C | rs16878204 | 23648065 | 2.57E-05 | Recessive model | 1.75 | [1.22-2.53] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16878204-T | Research Support, Non-U.S. Gov't |
| 5 | 80187929 | rs12522063 | T | G | rs12522063 | 23648065 | 4.22E-05 | Recessive model | 1.74 | [1.20-2.51] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12522063-T | Research Support, Non-U.S. Gov't |
| 5 | 80201284 | rs6864713 | G | A | rs6864713 | 23648065 | 7.11E-05 | Recessive model | 1.72 | [1.19-2.48] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6864713-C | Research Support, Non-U.S. Gov't |
| 5 | 85687037 | rs10059045 | A | C | rs10059045 | 23648065 | 7.35E-05 | Dominant model | 1.39 | [1.11-1.75] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10059045-A | Research Support, Non-U.S. Gov't |
| 5 | 85746871 | rs1500258 | A | G | rs1500258 | 23648065 | 2.85E-05 | Recessive model | 1.38 | [1.10-1.74] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1500258-C | Research Support, Non-U.S. Gov't |
| 5 | 85764555 | rs1553241 | A | C | rs1553241 | 23648065 | 5.35E-05 | Dominant model | 1.43 | [1.14-1.79] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1553241-C | Research Support, Non-U.S. Gov't |
| 5 | 86155113 | rs4133446 | T | C | rs4133446 | pha003095 | 7.15E-05 | phs000221 | phs000501 | 0.2 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4133446-T | NA |
| 5 | 86727027 | rs7702514 | C | T | rs7702514 | 23648065 | 2.16E-05 | Allelic model | 3.46 | [1.92-6.26] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7702514-A | Research Support, Non-U.S. Gov't |
| 5 | 92110386 | rs258959 | C | T | rs258959 | 23648065 | 9.17E-05 | Recessive model | 1.35 | NA | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs258959-A | Research Support, Non-U.S. Gov't |
| 5 | 92149000 | rs1429056 | T | C | rs1429056 | 23648065 | 9.20E-05 | Recessive model | 1.44 | [1.06-1.94] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1429056-G | Research Support, Non-U.S. Gov't |
| 5 | 92980916 | rs12186878 | C | A | rs12186878 | 23648065 | 2.07E-05 | Dominant model | 1.81 | [1.32-2.47] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12186878-G | Research Support, Non-U.S. Gov't |
| 5 | 98273862 | rs161937 | A | G | rs161937 | 23648065 | 4.05E-05 | Allelic model | 2.27 | [1.51-3.40] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs161937-A | Research Support, Non-U.S. Gov't |
| 5 | 98644175 | rs4702966 | C | T | rs4702966 | 23648065 | 5.78E-05 | Recessive model | 2.01 | [1.37-2.95] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4702966-A | Research Support, Non-U.S. Gov't |
| 5 | 98802762 | rs6885370 | C | T | rs6885370 | 23648065 | 7.86E-05 | Dominant model | 4.78 | [2.23-10.22] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6885370-A | Research Support, Non-U.S. Gov't |
| 5 | 99959205 | rs247932 | C | T | rs247932 | 23648065 | 9.67E-05 | Allelic model | 1.44 | [1.20-1.73] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs247932-G | Research Support, Non-U.S. Gov't |
| 5 | 104199060 | rs1632744 | T | C | rs1632744 | 23648065 | 5.00E-06 | Recessive model | 1.39 | [0.96-2.01] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1632744-T | Research Support, Non-U.S. Gov't |
| 5 | 104208013 | rs10074959 | G | A | rs10074959 | 23648065 | 1.00E-06 | Recessive model | 1.52 | [1.05-2.22] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10074959-T | Research Support, Non-U.S. Gov't |
| 5 | 107721366 | rs11240962 | C | A | rs11240962 | 23648065 | 1.81E-05 | Dominant model | 4.47 | [2.20-9.08] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11240962-T | Research Support, Non-U.S. Gov't |
| 5 | 107724017 | rs10035966 | T | G | rs10035966 | 23648065 | 1.81E-05 | Dominant model | 4.47 | [2.20-9.08] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10035966-G | Research Support, Non-U.S. Gov't |
| 5 | 107731684 | rs4634342 | G | T | rs4634342 | 23648065 | 1.12E-05 | Dominant model | 2.48 | [1.63-3.75] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4634342-C | Research Support, Non-U.S. Gov't |
| 5 | 107732317 | rs1122826 | G | A | rs1122826 | 23648065 | 1.81E-05 | Dominant model | 4.47 | [2.20-9.08] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1122826-A | Research Support, Non-U.S. Gov't |
| 5 | 107742569 | rs10455007 | A | C | rs10455007 | 23648065 | 4.10E-05 | Allelic model | 2.21 | [1.50-3.25] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10455007-A | Research Support, Non-U.S. Gov't |
| 5 | 107768782 | rs12187433 | T | C | rs12187433 | 23648065 | 2.44E-05 | Dominant model | 4.57 | [2.20-9.50] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12187433-G | Research Support, Non-U.S. Gov't |
| 5 | 120049065 | rs9285894 | A | G | rs9285894 | 23648065 | 1.10E-05 | Recessive model | 1.27 | [0.97-1.67] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9285894-G | Research Support, Non-U.S. Gov't |
| 5 | 121826721 | rs1000590 | G | A | rs1000590 | 23648065 | 6.89E-05 | Dominant model | 1.68 | [1.20-2.36] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1000590-A | Research Support, Non-U.S. Gov't |
| 5 | 121826941 | rs2407209 | G | A | rs2407209 | 23648065 | 6.89E-05 | Dominant model | 1.68 | [1.20-2.36] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2407209-T | Research Support, Non-U.S. Gov't |
| 5 | 124006906 | rs6895878 | T | C | rs6895878 | 23648065 | 9.06E-05 | Allelic model | 1.85 | [1.33-2.57] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6895878-C | Research Support, Non-U.S. Gov't |
| 5 | 124038251 | rs12513661 | G | A | rs12513661 | 23648065 | 7.21E-05 | Allelic model | 2.52 | [1.57-4.05] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12513661-T | Research Support, Non-U.S. Gov't |
| 5 | 134846824 | rs12374511 | A | C | rs12374511 | 23648065 | 4.61E-05 | Dominant model | 1.38 | [1.13-1.68] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12374511-C | Research Support, Non-U.S. Gov't |
| 5 | 134876123 | rs13356152 | T | C | rs13356152 | 23648065 | 7.95E-05 | Dominant model | 1.42 | [1.18-1.70] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13356152-G | Research Support, Non-U.S. Gov't |
| 5 | 140519166 | rs246723 | A | G | rs246723 | 23648065 | 9.85E-05 | Allelic model | 1.64 | [1.28-2.09] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs246723-C | Research Support, Non-U.S. Gov't |
| 5 | 140606802 | rs2907320 | C | T | rs2907320 | 23648065 | 2.56E-05 | Allelic model | 2.55 | [1.66-3.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2907320-A | Research Support, Non-U.S. Gov't |
| 5 | 140614038 | rs2907309 | G | A | rs2907309 | 23648065 | 2.56E-05 | Allelic model | 2.55 | [1.66-3.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2907309-A | Research Support, Non-U.S. Gov't |
| 5 | 140614830 | rs2907308 | G | A | rs2907308 | 23648065 | 2.56E-05 | Allelic model | 2.55 | [1.66-3.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2907308-T | Research Support, Non-U.S. Gov't |
| 5 | 140615269 | rs2907307 | A | G | rs2907307 | 23648065 | 2.56E-05 | Allelic model | 2.55 | [1.66-3.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2907307-C | Research Support, Non-U.S. Gov't |
| 5 | 140631925 | rs2910337 | T | G | rs2910337 | 23648065 | 2.56E-05 | Allelic model | 2.55 | [1.66-3.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2910337-G | Research Support, Non-U.S. Gov't |
| 5 | 142020380 | rs10070885 | C | T | rs10070885 | 23648065 | 6.34E-05 | Allelic model | 1.71 | [1.31-2.23] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10070885-C | Research Support, Non-U.S. Gov't |
| 5 | 146126245 | rs7715375 | G | A | rs7715375 | 23648065 | 4.06E-05 | Dominant model | 1.5 | [1.21-1.87] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7715375-G | Research Support, Non-U.S. Gov't |
| 5 | 149443298 | rs216140 | C | T | rs216140 | 23648065 | 7.00E-05 | Recessive model | 1.77 | [1.12-2.81] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs216140-A | Research Support, Non-U.S. Gov't |
| 5 | 150967836 | rs766206 | C | T | rs766206 | 23648065 | 4.17E-05 | Dominant model | 2.15 | [1.45-3.19] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs766206-A | Research Support, Non-U.S. Gov't |
| 5 | 158418490 | rs10447210 | C | T | rs10447210 | 23648065 | 7.75E-06 | Recessive model | 1.45 | [1.11-1.89] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10447210-G | Research Support, Non-U.S. Gov't |
| 5 | 158424391 | rs10040979 | G | A | rs10040979 | 23648065 | 5.00E-07 | Recessive model | 1.45 | [1.12-1.88] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10040979-G | Research Support, Non-U.S. Gov't |
| 5 | 158459721 | rs7720283 | T | C | rs7720283 | 23648065 | 4.15E-06 | Recessive model | 1.43 | [1.08-1.90] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7720283-C | Research Support, Non-U.S. Gov't |
| 5 | 158658012 | rs10515778 | A | G | rs10515778 | 23648065 | 8.07E-05 | Allelic model | 3.95 | [1.74-8.96] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10515778-T | Research Support, Non-U.S. Gov't |
| 5 | 159001299 | rs4315909 | A | G | rs4315909 | 23648065 | 2.81E-05 | Recessive model | 2 | [1.30-3.08] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4315909-G | Research Support, Non-U.S. Gov't |
| 5 | 159870611 | rs4921283 | G | A | rs4921283 | 23648065 | 3.73E-05 | Allelic model | 2.52 | [1.62-3.94] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4921283-G | Research Support, Non-U.S. Gov't |
| 5 | 160689448 | rs173564 | T | C | rs173564 | 23648065 | 5.31E-05 | Allelic model | 2.21 | [1.49-3.27] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs173564-C | Research Support, Non-U.S. Gov't |
| 5 | 166268258 | rs12656909 | C | A | rs12656909 | 23648065 | 2.73E-05 | Dominant model | 2.41 | [1.55-3.76] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12656909-C | Research Support, Non-U.S. Gov't |
| 5 | 167051620 | rs17068860 | A | G | rs17068860 | 23648065 | 6.69E-05 | Allelic model | 1.82 | [1.36-2.45] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17068860-T | Research Support, Non-U.S. Gov't |
| 5 | 167147874 | rs10057680 | A | G | rs10057680 | 23648065 | 7.95E-05 | Allelic model | 2.19 | [1.48-3.26] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10057680-T | Research Support, Non-U.S. Gov't |
| 5 | 168170445 | rs10462978 | T | C | rs10462978 | 23648065 | 1.80E-05 | Dominant model | 2.19 | [1.51-3.17] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10462978-A | Research Support, Non-U.S. Gov't |
| 5 | 168847968 | rs13177680 | A | C | rs13177680 | 23648065 | 7.87E-05 | Allelic model | 6.82 | [2.09-22.23] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13177680-T | Research Support, Non-U.S. Gov't |
| 5 | 169538372 | rs4867918 | G | A | rs4867918 | 23648065 | 3.78E-05 | Recessive model | 1.29 | [1.09-1.52] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4867918-C | Research Support, Non-U.S. Gov't |
| 5 | 169540547 | rs12653012 | G | A | rs12653012 | 23648065 | 4.22E-05 | Recessive model | 1.29 | [1.09-1.53] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12653012-G | Research Support, Non-U.S. Gov't |
| 5 | 169542600 | rs1895302 | C | T | rs1895302 | 23648065 | 7.00E-06 | Dominant model | 1.34 | [1.13-1.59] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1895302-C | Research Support, Non-U.S. Gov't |
| 5 | 169551625 | rs4867922 | C | T | rs4867922 | 23648065 | 1.36E-05 | Dominant model | 1.31 | [1.10-1.55] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4867922-C | Research Support, Non-U.S. Gov't |
| 5 | 172269595 | rs792978 | C | T | rs792978 | 23648065 | 1.69E-05 | Allelic model | 1.69 | [1.33-2.15] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs792978-G | Research Support, Non-U.S. Gov't |
| 5 | 172271007 | rs792975 | A | G | rs792975 | 23648065 | 8.00E-06 | Allelic model | 1.75 | [1.37-2.23] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs792975-T | Research Support, Non-U.S. Gov't |
| 5 | 172272207 | rs792969 | T | C | rs792969 | 23648065 | 9.94E-06 | Allelic model | 1.74 | [1.36-2.22] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs792969-G | Research Support, Non-U.S. Gov't |
| 5 | 172272571 | rs710109 | G | A | rs710109 | 23648065 | 1.74E-05 | Allelic model | 1.72 | [1.34-2.19] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs710109-C | Research Support, Non-U.S. Gov't |
| 5 | 172272571 | rs710109 | G | A | rs710109 | 23648065 | 6.66E-05 | Dominant model | 1.4 | [1.17-1.67] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs710109-C | Research Support, Non-U.S. Gov't |
| 5 | 173625154 | rs6863418 | T | C | rs6863418 | 23648065 | 7.00E-06 | Dominant model | 3.62 | [2.04-6.43] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6863418-A | Research Support, Non-U.S. Gov't |
| 5 | 175980113 | rs4868648 | T | C | rs4868648 | 23648065 | 3.62E-05 | Dominant model | 1.53 | [1.19-1.97] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4868648-T | Research Support, Non-U.S. Gov't |
| 5 | 176011264 | rs752139 | T | C | rs752139 | 23648065 | 7.65E-05 | Dominant model | 1.5 | [1.15-1.94] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs752139-A | Research Support, Non-U.S. Gov't |
| 6 | 477738 | rs7750350 | C | T | rs7750350 | 23648065 | 7.45E-05 | Dominant model | 1.56 | [1.22-1.99] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7750350-G | Research Support, Non-U.S. Gov't |
| 6 | 3837198 | rs17318866 | G | A | rs17318866 | 23648065 | 1.00E-06 | Allelic model | 7.56 | [2.69-21.26] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17318866-G | Research Support, Non-U.S. Gov't |
| 6 | 8945690 | rs9406226 | G | A | rs9406226 | 23648065 | 5.69E-05 | Dominant model | 1.84 | [1.30-2.61] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9406226-C | Research Support, Non-U.S. Gov't |
| 6 | 15215150 | rs12664987 | C | T | rs12664987 | 23648065 | 5.95E-05 | Allelic model | 1.9 | [1.39-2.59] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12664987-C | Research Support, Non-U.S. Gov't |
| 6 | 21259328 | rs6935795 | G | T | rs6935795 | 23648065 | 5.97E-05 | Recessive model | 1.43 | [1.12-1.83] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6935795-G | Research Support, Non-U.S. Gov't |
| 6 | 22046317 | rs1736512 | A | G | rs1736512 | 23648065 | 1.10E-05 | Recessive model | 1.88 | [1.22-2.91] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1736512-T | Research Support, Non-U.S. Gov't |
| 6 | 22046317 | rs1736512 | A | G | rs1736512 | 23648065 | 2.95E-05 | Recessive model | 1.49 | [1.08-2.06] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1736512-T | Research Support, Non-U.S. Gov't |
| 6 | 24749413 | rs17419851 | C | T | rs17419851 | 21507922 | 9.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 6 | 28466442 | rs12661782 | A | G | rs12661782 | 23648065 | 3.07E-05 | Allelic model | 2.53 | [1.64-3.90] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12661782-C | Research Support, Non-U.S. Gov't |
| 6 | 28473325 | rs2071966 | T | G | rs2071966 | 23648065 | 3.07E-05 | Allelic model | 2.53 | [1.64-3.90] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2071966-C | Research Support, Non-U.S. Gov't |
| 6 | 28500235 | rs769189 | T | C | rs769189 | 23648065 | 5.21E-05 | Allelic model | 2.44 | [1.58-3.76] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs769189-C | Research Support, Non-U.S. Gov't |
| 6 | 32914613 | rs194682 | C | T | rs194682 | 23648065 | 7.58E-05 | Recessive model | 1.46 | [1.14-1.87] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs194682-T | Research Support, Non-U.S. Gov't |
| 6 | 32932150 | rs206783 | C | A | rs206783 | 23648065 | 5.94E-05 | Recessive model | 1.48 | [1.15-1.89] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs206783-T | Research Support, Non-U.S. Gov't |
| 6 | 32935179 | rs206786 | A | C | rs206786 | 23648065 | 5.94E-05 | Recessive model | 1.48 | [1.15-1.89] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs206786-C | Research Support, Non-U.S. Gov't |
| 6 | 41296090 | rs9471566 | C | A | rs9471566 | 23648065 | 2.45E-05 | Dominant model | 1.68 | [1.30-2.16] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9471566-T | Research Support, Non-U.S. Gov't |
| 6 | 41925304 | rs11968166 | G | A | rs11968166 | 21507922 | 8.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 6 | 42025318 | rs12208813 | G | A | rs12208813 | 23648065 | 7.37E-05 | Allelic model | 3.25 | [1.74-6.09] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12208813-C | Research Support, Non-U.S. Gov't |
| 6 | 42037167 | rs12194513 | C | T | rs12194513 | 23648065 | 7.37E-05 | Allelic model | 3.25 | [1.74-6.09] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12194513-C | Research Support, Non-U.S. Gov't |
| 6 | 43882612 | rs9472153 | G | A | rs9472153 | 23648065 | 1.28E-05 | Dominant model | 1.62 | [1.23-2.12] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9472153-C | Research Support, Non-U.S. Gov't |
| 6 | 44051221 | rs6458368 | T | C | rs6458368 | 23648065 | 8.63E-05 | Allelic model | 1.88 | [1.38-2.57] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6458368-A | Research Support, Non-U.S. Gov't |
| 6 | 44081718 | rs6883 | G | A | rs6883 | 23648065 | 7.33E-05 | Dominant model | 1.79 | [1.34-2.41] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6883-G | Research Support, Non-U.S. Gov't |
| 6 | 44191920 | rs693955 | A | C | rs693955 | 23648065 | 5.65E-05 | Dominant model | 2.85 | [1.64-4.95] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs693955-C | Research Support, Non-U.S. Gov't |
| 6 | 47187915 | rs4629675 | T | C | rs4629675 | 23648065 | 6.52E-05 | Recessive model | 1.42 | [1.11-1.83] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4629675-T | Research Support, Non-U.S. Gov't |
| 6 | 50522228 | rs984329 | C | T | rs984329 | 23648065 | 1.27E-05 | Allelic model | 1.74 | [1.36-2.22] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs984329-T | Research Support, Non-U.S. Gov't |
| 6 | 50522228 | rs984329 | C | T | rs984329 | 23648065 | 3.42E-05 | Allelic model | 1.43 | [1.21-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs984329-T | Research Support, Non-U.S. Gov't |
| 6 | 50528436 | rs280344 | T | C | rs280344 | 23648065 | 3.40E-05 | Allelic model | 1.68 | [1.32-2.15] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs280344-G | Research Support, Non-U.S. Gov't |
| 6 | 50548918 | rs9367402 | C | T | rs9367402 | 23648065 | 1.25E-05 | Allelic model | 1.74 | [1.36-2.23] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9367402-A | Research Support, Non-U.S. Gov't |
| 6 | 50548918 | rs9367402 | C | T | rs9367402 | 23648065 | 2.88E-05 | Allelic model | 1.44 | [1.21-1.70] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9367402-A | Research Support, Non-U.S. Gov't |
| 6 | 50576468 | rs1161444 | C | T | rs1161444 | 23648065 | 4.36E-05 | Allelic model | 1.68 | [1.31-2.15] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1161444-A | Research Support, Non-U.S. Gov't |
| 6 | 51572515 | rs9395707 | G | A | rs9395707 | 23648065 | 6.10E-05 | Allelic model | 2.05 | [1.44-2.93] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9395707-A | Research Support, Non-U.S. Gov't |
| 6 | 54310853 | rs243799 | C | T | rs243799 | 23648065 | 1.87E-05 | Dominant model | 2.11 | [1.48-3.00] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs243799-C | Research Support, Non-U.S. Gov't |
| 6 | 54424937 | rs6459009 | T | G | rs6459009 | 23648065 | 3.32E-05 | Dominant model | 1.9 | [1.36-2.68] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6459009-G | Research Support, Non-U.S. Gov't |
| 6 | 54441359 | rs1853335 | G | A | rs1853335 | 23648065 | 5.86E-05 | Dominant model | 1.96 | [1.39-2.76] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1853335-A | Research Support, Non-U.S. Gov't |
| 6 | 66106319 | rs9453294 | T | C | rs9453294 | 23648065 | 3.46E-05 | Recessive model | 1.69 | [1.08-2.65] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9453294-A | Research Support, Non-U.S. Gov't |
| 6 | 66112409 | rs974110 | A | G | rs974110 | 23648065 | 3.46E-05 | Recessive model | 1.69 | [1.08-2.65] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs974110-T | Research Support, Non-U.S. Gov't |
| 6 | 73740864 | rs10498887 | G | A,C | rs10498887 | 23648065 | 5.09E-05 | Dominant model | 2.17 | [1.41-3.35] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10498887-G | Research Support, Non-U.S. Gov't |
| 6 | 77266188 | rs4235898 | G | A | rs4235898 | 23648065 | 1.00E-06 | Allelic model | 1.72 | [1.38-2.14] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4235898-A | Research Support, Non-U.S. Gov't |
| 6 | 78531689 | rs9359294 | A | G | rs9359294 | 23648065 | 8.61E-05 | Allelic model | 2.1 | [1.45-3.04] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9359294-T | Research Support, Non-U.S. Gov't |
| 6 | 80512765 | rs9448824 | G | T | rs9448824 | 23648065 | 4.25E-05 | Dominant model | 2.27 | [1.42-3.62] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9448824-C | Research Support, Non-U.S. Gov't |
| 6 | 82496434 | rs194615 | T | C | rs194615 | 23648065 | 8.76E-05 | Dominant model | 2.51 | [1.54-4.08] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs194615-C | Research Support, Non-U.S. Gov't |
| 6 | 90465626 | rs6942026 | T | G | rs6942026 | 23648065 | 4.39E-05 | Dominant model | 2.9 | [1.57-5.34] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6942026-C | Research Support, Non-U.S. Gov't |
| 6 | 95202197 | rs1022787 | G | A | rs1022787 | 23648065 | 9.44E-05 | Allelic model | 1.64 | [1.28-2.10] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1022787-G | Research Support, Non-U.S. Gov't |
| 6 | 96008082 | rs7748108 | T | C | rs7748108 | 23648065 | 7.66E-05 | Dominant model | 3.47 | [1.59-7.54] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7748108-C | Research Support, Non-U.S. Gov't |
| 6 | 98361795 | rs6934784 | A | C | rs6934784 | 23648065 | 3.31E-05 | Allelic model | 1.68 | [1.32-2.14] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6934784-C | Research Support, Non-U.S. Gov't |
| 6 | 98379027 | rs6940021 | G | A | rs6940021 | 23648065 | 3.40E-05 | Allelic model | 1.67 | [1.31-2.13] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6940021-A | Research Support, Non-U.S. Gov't |
| 6 | 98470233 | rs17813462 | T | C | rs17813462 | 23648065 | 4.49E-05 | Allelic model | 1.83 | [1.38-2.44] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17813462-C | Research Support, Non-U.S. Gov't |
| 6 | 98489654 | rs4839936 | C | T | rs4839936 | 23648065 | 1.03E-05 | Allelic model | 1.75 | [1.37-2.23] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4839936-T | Research Support, Non-U.S. Gov't |
| 6 | 98495952 | rs2505059 | A | G | rs2505059 | 23648065 | 5.00E-06 | Allelic model | 1.77 | [1.38-2.25] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2505059-G | Research Support, Non-U.S. Gov't |
| 6 | 98560826 | rs1906251 | C | A | rs1906251 | 23648065 | 9.48E-06 | Allelic model | 1.74 | [1.37-2.22] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1906251-C | Research Support, Non-U.S. Gov't |
| 6 | 98597689 | rs1487452 | C | T | rs1487452 | 23648065 | 7.61E-06 | Allelic model | 1.75 | [1.37-2.23] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1487452-T | Research Support, Non-U.S. Gov't |
| 6 | 98626561 | rs9372752 | G | A | rs9372752 | 23648065 | 1.68E-05 | Allelic model | 1.72 | [1.34-2.19] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9372752-G | Research Support, Non-U.S. Gov't |
| 6 | 98634277 | rs2505081 | C | T | rs2505081 | 23648065 | 6.95E-05 | Allelic model | 1.64 | [1.29-2.10] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2505081-G | Research Support, Non-U.S. Gov't |
| 6 | 98652595 | rs1376499 | C | A | rs1376499 | 23648065 | 2.25E-05 | Allelic model | 1.7 | [1.33-2.17] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1376499-C | Research Support, Non-U.S. Gov't |
| 6 | 101976291 | rs2518251 | T | G | rs2518251 | 23648065 | 6.92E-05 | Recessive model | 1.63 | [1.15-2.29] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2518251-G | Research Support, Non-U.S. Gov't |
| 6 | 105757070 | rs1617445 | C | T | rs1617445 | 23648065 | 6.33E-05 | Allelic model | 2.29 | [1.50-3.48] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1617445-G | Research Support, Non-U.S. Gov't |
| 6 | 106329055 | rs9386485 | C | T | rs9386485 | 23648065 | 1.00E-06 | Allelic model | 1.82 | [1.43-2.32] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9386485-T | Research Support, Non-U.S. Gov't |
| 6 | 106329055 | rs9386485 | C | T | rs9386485 | 23648065 | 3.00E-06 | Allelic model | 1.52 | [1.28-1.82] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9386485-T | Research Support, Non-U.S. Gov't |
| 6 | 118117246 | rs11755280 | T | C | rs11755280 | 23648065 | 9.09E-05 | Dominant model | 1.35 | [1.12-1.63] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11755280-A | Research Support, Non-U.S. Gov't |
| 6 | 119320313 | rs794266 | A | G | rs794266 | pha003095 | 2.18E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs794266-A | NA |
| 6 | 120284989 | rs9401193 | A | C | rs9401193 | 23648065 | 3.23E-05 | Dominant model | 2.89 | [1.68-4.97] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9401193-C | Research Support, Non-U.S. Gov't |
| 6 | 124681503 | rs12204812 | C | A | rs12204812 | 23648065 | 4.16E-05 | Dominant model | 5.51 | [2.18-13.93] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12204812-T | Research Support, Non-U.S. Gov't |
| 6 | 124681503 | rs12204812 | C | A | rs12204812 | 23648065 | 5.69E-05 | Dominant model | 2.33 | [1.52-3.56] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12204812-T | Research Support, Non-U.S. Gov't |
| 6 | 124688755 | rs911959 | T | C | rs911959 | 23648065 | 3.97E-05 | Allelic model | 8.75 | [2.55-29.98] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs911959-G | Research Support, Non-U.S. Gov't |
| 6 | 129673689 | rs9385488 | T | C | rs9385488 | 23648065 | 5.47E-05 | Allelic model | 3.83 | [1.94-7.60] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9385488-C | Research Support, Non-U.S. Gov't |
| 6 | 129674757 | rs3813367 | G | T | rs3813367 | 23648065 | 5.09E-05 | Allelic model | 4.13 | [1.98-8.61] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3813367-A | Research Support, Non-U.S. Gov't |
| 6 | 129700998 | rs17057200 | C | T | rs17057200 | 23648065 | 5.09E-05 | Allelic model | 4.13 | [1.98-8.61] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17057200-T | Research Support, Non-U.S. Gov't |
| 6 | 130005667 | rs6920979 | G | T | rs6920979 | 23648065 | 8.50E-06 | Dominant model | 2.34 | [1.59-3.44] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6920979-C | Research Support, Non-U.S. Gov't |
| 6 | 130008445 | rs12660691 | A | C | rs12660691 | 23648065 | 4.00E-06 | Allelic model | 3.2 | [1.90-5.39] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12660691-A | Research Support, Non-U.S. Gov't |
| 6 | 130021128 | rs2157460 | A | G | rs2157460 | 23648065 | 7.07E-06 | Allelic model | 3.01 | [1.81-5.03] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2157460-T | Research Support, Non-U.S. Gov't |
| 6 | 130029839 | rs2068685 | G | A | rs2068685 | 23648065 | 8.90E-06 | Allelic model | 2.94 | [1.78-4.85] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2068685-G | Research Support, Non-U.S. Gov't |
| 6 | 132203432 | rs7768480 | A | G | rs7768480 | pha003095 | 3.62E-05 | phs000221 | phs000501 | 0.42 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7768480-G | NA |
| 6 | 141428255 | rs9389870 | T | C | rs9389870 | 23648065 | 7.81E-05 | Allelic model | 1.95 | [1.40-2.71] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9389870-T | Research Support, Non-U.S. Gov't |
| 6 | 142093922 | rs9496139 | A | G | rs9496139 | 23648065 | 7.02E-05 | Allelic model | 2.44 | [1.59-3.75] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9496139-C | Research Support, Non-U.S. Gov't |
| 6 | 142822217 | rs9496398 | T | C | rs9496398 | 21507922 | 4.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 6 | 147326634 | rs1406537 | C | T | rs1406537 | 23648065 | 7.45E-05 | Dominant model | 1.61 | [1.20-2.17] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1406537-A | Research Support, Non-U.S. Gov't |
| 6 | 147366538 | rs11969474 | T | C | rs11969474 | 23648065 | 8.24E-05 | Allelic model | 2.72 | [1.64-4.53] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11969474-A | Research Support, Non-U.S. Gov't |
| 6 | 147368934 | rs6907758 | C | T | rs6907758 | 23648065 | 8.24E-05 | Allelic model | 2.72 | [1.64-4.53] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6907758-C | Research Support, Non-U.S. Gov't |
| 6 | 147409180 | rs12664682 | G | A | rs12664682 | 23648065 | 3.88E-05 | Allelic model | 3.13 | [1.78-5.51] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12664682-C | Research Support, Non-U.S. Gov't |
| 6 | 147409235 | rs12661753 | A | G | rs12661753 | 23648065 | 3.88E-05 | Allelic model | 3.13 | [1.78-5.51] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12661753-A | Research Support, Non-U.S. Gov't |
| 6 | 147414032 | rs7771711 | G | A | rs7771711 | 23648065 | 3.88E-05 | Allelic model | 3.13 | [1.78-5.51] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7771711-G | Research Support, Non-U.S. Gov't |
| 6 | 147635547 | rs1039085 | C | T | rs1039085 | 23648065 | 5.39E-05 | Allelic model | 2 | [1.42-2.82] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1039085-G | Research Support, Non-U.S. Gov't |
| 6 | 152229850 | rs2347867 | G | A | rs2347867 | 23648065 | 3.14E-05 | Allelic model | 1.79 | [1.37-2.34] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2347867-A | Research Support, Non-U.S. Gov't |
| 6 | 156582195 | rs12661043 | T | C | rs12661043 | 23648065 | 5.09E-05 | Allelic model | 1.89 | [1.36-2.60] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12661043-T | Research Support, Non-U.S. Gov't |
| 6 | 157265752 | rs10485203 | T | C | rs10485203 | 23648065 | 7.94E-05 | Dominant model | 1.48 | [1.20-1.84] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10485203-T | Research Support, Non-U.S. Gov't |
| 6 | 158689753 | rs9355613 | T | C | rs9355613 | 23648065 | 9.89E-05 | Allelic model | 1.64 | [1.28-2.10] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9355613-G | Research Support, Non-U.S. Gov't |
| 6 | 161988513 | rs9456684 | G | A | rs9456684 | 23648065 | 3.79E-05 | Allelic model | 2.21 | [1.52-3.20] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9456684-G | Research Support, Non-U.S. Gov't |
| 6 | 161988767 | rs9355351 | A | G | rs9355351 | 23648065 | 5.53E-05 | Allelic model | 2.18 | [1.50-3.16] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9355351-T | Research Support, Non-U.S. Gov't |
| 6 | 161989903 | rs885782 | A | C | rs885782 | 23648065 | 1.07E-05 | Recessive model | 2.17 | [1.51-3.14] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs885782-T | Research Support, Non-U.S. Gov't |
| 6 | 162006836 | rs9364605 | C | T | rs9364605 | 23648065 | 2.16E-05 | Allelic model | 2.24 | [1.54-3.26] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9364605-C | Research Support, Non-U.S. Gov't |
| 6 | 162575299 | rs869298 | C | T | rs869298 | 23648065 | 5.27E-05 | Dominant model | 2.06 | [1.46-2.90] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs869298-G | Research Support, Non-U.S. Gov't |
| 6 | 162577258 | rs2849609 | C | T | rs2849609 | 23648065 | 1.92E-05 | Dominant model | 1.71 | [1.34-2.18] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2849609-C | Research Support, Non-U.S. Gov't |
| 6 | 162577258 | rs2849609 | C | T | rs2849609 | 23648065 | 3.08E-05 | Dominant model | 2 | [1.46-2.75] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2849609-C | Research Support, Non-U.S. Gov't |
| 6 | 167398071 | rs394522 | A | C | rs394522 | 23648065 | 5.81E-05 | Recessive model | 1.38 | [1.10-1.74] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs394522-C | Research Support, Non-U.S. Gov't |
| 6 | 167398071 | rs394522 | A | C | rs394522 | 23648065 | 8.97E-05 | Recessive model | 1.28 | [1.08-1.52] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs394522-C | Research Support, Non-U.S. Gov't |
| 6 | 170347127 | rs1466749 | G | A | rs1466749 | 23648065 | 7.57E-05 | Allelic model | 1.99 | [1.41-2.80] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1466749-A | Research Support, Non-U.S. Gov't |
| 7 | 2032803 | rs11764590 | C | T | rs11764590 | pha003095 | 5.84E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11764590-T | NA |
| 7 | 5396955 | rs7805732 | A | G | rs7805732 | 23648065 | 5.93E-05 | Dominant model | 1.61 | [1.23-2.11] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7805732-G | Research Support, Non-U.S. Gov't |
| 7 | 9247266 | rs4720829 | T | C | rs4720829 | 23648065 | 2.70E-05 | Dominant model | 1.6 | [1.24-2.06] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4720829-A | Research Support, Non-U.S. Gov't |
| 7 | 11677126 | rs12154996 | A | G | rs12154996 | 23648065 | 4.45E-05 | Allelic model | 2.51 | [1.62-3.87] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12154996-G | Research Support, Non-U.S. Gov't |
| 7 | 12094966 | rs1035147 | A | C | rs1035147 | 23648065 | 4.00E-06 | Allelic model | 7.29 | [2.59-20.56] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1035147-T | Research Support, Non-U.S. Gov't |
| 7 | 12708504 | rs13226473 | A | G | rs13226473 | 23648065 | 3.36E-05 | Allelic model | 2.03 | [1.47-2.79] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13226473-G | Research Support, Non-U.S. Gov't |
| 7 | 12713070 | rs10488226 | G | T | rs10488226 | 23648065 | 3.00E-06 | Dominant model | 2.03 | [1.50-2.74] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10488226-A | Research Support, Non-U.S. Gov't |
| 7 | 13238496 | rs16877717 | G | A | rs16877717 | 23648065 | 1.85E-05 | Recessive model | 1.85 | [1.17-2.91] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16877717-T | Research Support, Non-U.S. Gov't |
| 7 | 16861849 | rs10253216 | G | A | rs10253216 | 23648065 | 2.00E-07 | Dominant model | 1.48 | [1.16-1.89] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10253216-T | Research Support, Non-U.S. Gov't |
| 7 | 16862235 | rs7797977 | G | T | rs7797977 | 23648065 | 2.17E-06 | Recessive model | 1.46 | [1.13-1.88] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7797977-C | Research Support, Non-U.S. Gov't |
| 7 | 16863727 | rs11768848 | C | A | rs11768848 | 23648065 | 2.16E-06 | Recessive model | 1.46 | [1.13-1.89] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11768848-C | Research Support, Non-U.S. Gov't |
| 7 | 16878113 | rs10232481 | T | G | rs10232481 | 23648065 | 3.47E-07 | Dominant model | 1.49 | [1.16-1.90] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10232481-C | Research Support, Non-U.S. Gov't |
| 7 | 16882053 | rs1404966 | A | G | rs1404966 | 23648065 | 5.58E-06 | Dominant model | 1.45 | [1.13-1.85] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1404966-G | Research Support, Non-U.S. Gov't |
| 7 | 16884241 | rs17136737 | T | G | rs17136737 | 23648065 | 4.90E-06 | Dominant model | 1.46 | [1.15-1.87] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17136737-C | Research Support, Non-U.S. Gov't |
| 7 | 16884241 | rs17136737 | T | G | rs17136737 | 23648065 | 8.73E-05 | Dominant model | 1.3 | [1.10-1.54] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17136737-C | Research Support, Non-U.S. Gov't |
| 7 | 17028698 | rs4529355 | C | T | rs4529355 | pha003095 | 9.29E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4529355-T | NA |
| 7 | 17085321 | rs6961860 | C | T | rs6961860 | 23648065 | 5.00E-06 | Recessive model | 1.28 | [1.08-1.53] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6961860-G | Research Support, Non-U.S. Gov't |
| 7 | 17277084 | rs1476079 | C | A | rs1476079 | 23648065 | 7.43E-05 | Recessive model | 1.48 | [1.17-1.86] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1476079-A | Research Support, Non-U.S. Gov't |
| 7 | 19371245 | rs9654950 | A | G | rs9654950 | 23648065 | 2.42E-05 | Recessive model | 1.99 | [1.28-3.08] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9654950-G | Research Support, Non-U.S. Gov't |
| 7 | 20255705 | rs3095008 | G | A | rs3095008 | 23648065 | 9.00E-06 | Dominant model | NA | NA | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3095008-T | Research Support, Non-U.S. Gov't |
| 7 | 21980773 | rs6946675 | A | C | rs6946675 | 23648065 | 5.81E-05 | Allelic model | 1.73 | [1.32-2.25] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6946675-T | Research Support, Non-U.S. Gov't |
| 7 | 26191698 | rs2073536 | T | C | rs2073536 | 23648065 | 9.86E-05 | Recessive model | 1.54 | [1.14-2.07] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2073536-C | Research Support, Non-U.S. Gov't |
| 7 | 32255322 | rs4723134 | C | T | rs4723134 | 23648065 | 9.09E-05 | Allelic model | 1.97 | [1.41-2.74] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4723134-A | Research Support, Non-U.S. Gov't |
| 7 | 34178283 | rs12673452 | G | A | rs12673452 | 23648065 | 1.61E-05 | Allelic model | 4.27 | [2.16-8.42] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12673452-A | Research Support, Non-U.S. Gov't |
| 7 | 34405042 | rs17169771 | A | G | rs17169771 | 23648065 | 4.68E-05 | Recessive model | 1.38 | [1.09-1.74] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17169771-A | Research Support, Non-U.S. Gov't |
| 7 | 34407843 | rs10280909 | A | G | rs10280909 | 23648065 | 4.71E-05 | Recessive model | 1.37 | [1.08-1.74] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10280909-A | Research Support, Non-U.S. Gov't |
| 7 | 37562368 | rs1425132 | A | G | rs1425132 | 23648065 | 5.00E-06 | Recessive model | 1.43 | [1.01-2.02] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1425132-T | Research Support, Non-U.S. Gov't |
| 7 | 39304125 | rs4302750 | A | G | rs4302750 | 23648065 | 9.89E-05 | Dominant model | 1.64 | [1.27-2.11] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4302750-G | Research Support, Non-U.S. Gov't |
| 7 | 43506158 | rs2304328 | T | C | rs2304328 | 23648065 | 8.17E-05 | Recessive model | 1.38 | [1.09-1.75] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2304328-G | Research Support, Non-U.S. Gov't |
| 7 | 45554986 | rs7793106 | A | G | rs7793106 | 23648065 | 5.27E-05 | Dominant model | 2.4 | [1.54-3.73] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7793106-C | Research Support, Non-U.S. Gov't |
| 7 | 47432669 | rs2470996 | A | C | rs2470996 | 23648065 | 2.45E-05 | Recessive model | 1.75 | [1.23-2.48] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2470996-T | Research Support, Non-U.S. Gov't |
| 7 | 50243488 | rs1037676 | A | C | rs1037676 | 23648065 | 5.76E-05 | Allelic model | 4.89 | [1.95-12.26] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1037676-A | Research Support, Non-U.S. Gov't |
| 7 | 50249013 | rs11761913 | C | T | rs11761913 | 23648065 | 1.26E-05 | Allelic model | 2.06 | [1.48-2.86] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11761913-A | Research Support, Non-U.S. Gov't |
| 7 | 50249013 | rs11761913 | C | T | rs11761913 | 23648065 | 5.57E-05 | Allelic model | 2.42 | [1.56-3.77] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11761913-A | Research Support, Non-U.S. Gov't |
| 7 | 50460096 | rs6964823 | G | A | rs6964823 | 23648065 | 2.45E-05 | Recessive model | 1.25 | [1.00-1.56] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6964823-A | Research Support, Non-U.S. Gov't |
| 7 | 50476139 | rs12719019 | C | T | rs12719019 | 23648065 | 5.19E-05 | Recessive model | 1.18 | [0.94-1.47] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12719019-T | Research Support, Non-U.S. Gov't |
| 7 | 54976715 | rs10277377 | C | T | rs10277377 | 23648065 | 2.38E-05 | Allelic model | 2.5 | [1.64-3.81] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10277377-T | Research Support, Non-U.S. Gov't |
| 7 | 55169291 | rs4947491 | A | G | rs4947491 | 23648065 | 9.76E-05 | Dominant model | 2.35 | [1.41-3.94] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4947491-C | Research Support, Non-U.S. Gov't |
| 7 | 81225029 | rs2098560 | C | T | rs2098560 | 23648065 | 8.14E-05 | Dominant model | 3.99 | [1.99-8.00] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2098560-G | Research Support, Non-U.S. Gov't |
| 7 | 86965599 | rs996745 | C | T | rs996745 | pha003095 | 4.12E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs996745-C | NA |
| 7 | 86983715 | rs7808249 | A | G | rs7808249 | pha003095 | 7.08E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7808249-A | NA |
| 7 | 89635741 | rs10259230 | T | C | rs10259230 | 23648065 | 8.74E-05 | Recessive model | 1.56 | [1.04-2.34] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10259230-C | Research Support, Non-U.S. Gov't |
| 7 | 91680974 | rs10275125 | G | A | rs10275125 | 23648065 | 9.15E-05 | Allelic model | 4.2 | [2.04-8.65] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10275125-T | Research Support, Non-U.S. Gov't |
| 7 | 91691070 | rs2961024 | G | T | rs2961024 | 23648065 | 9.15E-05 | Allelic model | 4.2 | [2.04-8.65] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2961024-T | Research Support, Non-U.S. Gov't |
| 7 | 91736464 | rs12538678 | T | G | rs12538678 | 23648065 | 4.78E-05 | Allelic model | 4.43 | [2.15-9.12] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12538678-G | Research Support, Non-U.S. Gov't |
| 7 | 91892459 | rs17164470 | A | G | rs17164470 | 23648065 | 3.91E-05 | Allelic model | 4.94 | [2.27-10.73] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17164470-T | Research Support, Non-U.S. Gov't |
| 7 | 92031948 | rs38795 | G | A | rs38795 | 23648065 | 4.55E-05 | Allelic model | 4.38 | [2.12-9.05] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs38795-G | Research Support, Non-U.S. Gov't |
| 7 | 93787413 | rs7357193 | C | A | rs7357193 | 23648065 | 3.01E-05 | Recessive model | 1.34 | [1.12-1.62] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7357193-T | Research Support, Non-U.S. Gov't |
| 7 | 93930713 | rs12704714 | C | T | rs12704714 | 23648065 | 7.88E-05 | Dominant model | 1.66 | [1.27-2.17] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12704714-G | Research Support, Non-U.S. Gov't |
| 7 | 97425721 | rs1229568 | C | T | rs1229568 | 23648065 | 9.68E-05 | Recessive model | 1.5 | [1.00-2.25] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1229568-A | Research Support, Non-U.S. Gov't |
| 7 | 97432533 | rs1229553 | T | C | rs1229553 | 23648065 | 9.68E-05 | Recessive model | 1.5 | [1.00-2.25] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1229553-C | Research Support, Non-U.S. Gov't |
| 7 | 97854393 | rs2291745 | G | A | rs2291745 | 23648065 | 2.16E-05 | Allelic model | 2.24 | [1.54-3.26] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2291745-A | Research Support, Non-U.S. Gov't |
| 7 | 97863145 | rs2291750 | G | A | rs2291750 | 23648065 | 2.16E-05 | Allelic model | 2.24 | [1.54-3.26] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2291750-A | Research Support, Non-U.S. Gov't |
| 7 | 103396604 | rs579030 | T | C | rs579030 | pha003095 | 6.13E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs579030-C | NA |
| 7 | 106398153 | rs10953517 | G | A | rs10953517 | 23648065 | 7.73E-05 | Dominant model | 2.2 | [1.43-3.40] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10953517-C | Research Support, Non-U.S. Gov't |
| 7 | 107968803 | rs2267887 | G | A | rs2267887 | 23648065 | 9.09E-05 | Dominant model | 1.43 | [1.05-1.94] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2267887-T | Research Support, Non-U.S. Gov't |
| 7 | 122696223 | rs1404838 | T | C | rs1404838 | 23648065 | 7.69E-06 | Dominant model | 2.07 | [1.49-2.88] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1404838-A | Research Support, Non-U.S. Gov't |
| 7 | 122759980 | rs4727963 | C | T | rs4727963 | 23648065 | 1.00E-06 | Dominant model | 2.09 | [1.50-2.91] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4727963-C | Research Support, Non-U.S. Gov't |
| 7 | 122766907 | rs2204292 | C | T | rs2204292 | 23648065 | 1.04E-06 | Dominant model | 2.09 | [1.50-2.91] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2204292-T | Research Support, Non-U.S. Gov't |
| 7 | 122785428 | rs2470975 | A | G | rs2470975 | 23648065 | 5.29E-06 | Dominant model | 2 | [1.44-2.79] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2470975-G | Research Support, Non-U.S. Gov't |
| 7 | 122790213 | rs2462150 | C | G | rs2462150 | 23648065 | 3.27E-06 | Dominant model | 2.02 | [1.45-2.81] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2462150-G | Research Support, Non-U.S. Gov't |
| 7 | 130696720 | rs1588769 | C | T | rs1588769 | 23648065 | 8.07E-05 | Recessive model | 1.18 | [0.89-1.57] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1588769-A | Research Support, Non-U.S. Gov't |
| 7 | 131334612 | rs199973478 | T | TC | rs2909679 | 23648065 | 5.74E-05 | Recessive model | 1.4 | [1.16-1.68] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2909679-C | Research Support, Non-U.S. Gov't |
| 7 | 131334612 | rs2909679 | T | C | rs2909679 | 23648065 | 5.74E-05 | Recessive model | 1.4 | [1.16-1.68] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2909679-C | Research Support, Non-U.S. Gov't |
| 7 | 136339058 | rs10435421 | C | T | rs10435421 | 23648065 | 7.57E-05 | Allelic model | 4.53 | [2.03-10.09] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10435421-C | Research Support, Non-U.S. Gov't |
| 7 | 146751635 | rs10266239 | G | A | rs10266239 | 23648065 | 1.08E-05 | Allelic model | 2.34 | [1.59-3.44] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10266239-G | Research Support, Non-U.S. Gov't |
| 7 | 146751635 | rs10266239 | G | A | rs10266239 | 23648065 | 6.76E-05 | Allelic model | 2.68 | [1.62-4.43] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10266239-G | Research Support, Non-U.S. Gov't |
| 7 | 154934501 | rs4146256 | C | A | rs4146256 | 23648065 | 6.66E-05 | Allelic model | 15.24 | [2.08-111.82] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4146256-A | Research Support, Non-U.S. Gov't |
| 7 | 155057997 | rs4506162 | A | G | rs4506162 | 23648065 | 1.27E-05 | Allelic model | 5.76 | [2.26-14.72] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4506162-G | Research Support, Non-U.S. Gov't |
| 7 | 156025003 | rs9638164 | A | C | rs9638164 | pha003095 | 3.57E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9638164-A | NA |
| 7 | 156025396 | rs1175446 | T | C | rs1175446 | pha003095 | 2.64E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1175446-T | NA |
| 7 | 158038989 | rs10235911 | C | T | rs10235911 | 23648065 | 5.91E-05 | Recessive model | 1.35 | [1.06-1.71] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10235911-C | Research Support, Non-U.S. Gov't |
| 8 | 1033625 | rs2336695 | A | G | rs2336695 | 23648065 | 8.16E-05 | Allelic model | 1.71 | [1.31-2.23] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2336695-T | Research Support, Non-U.S. Gov't |
| 8 | 1842729 | rs3758004 | C | T | rs3758004 | 23648065 | 3.28E-05 | Allelic model | 3.36 | [1.87-6.06] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3758004-A | Research Support, Non-U.S. Gov't |
| 8 | 2064121 | rs12548396 | C | T | rs12548396 | 23648065 | 9.11E-05 | Allelic model | 1.63 | [1.28-2.08] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12548396-G | Research Support, Non-U.S. Gov't |
| 8 | 4060604 | rs4875308 | G | A | rs4875308 | 23648065 | 9.39E-05 | Allelic model | 1.65 | [1.29-2.11] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4875308-A | Research Support, Non-U.S. Gov't |
| 8 | 4105147 | rs1714746 | G | A | rs1714746 | 23648065 | 7.00E-06 | Recessive model | 1.61 | [1.26-2.06] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1714746-G | Research Support, Non-U.S. Gov't |
| 8 | 6323278 | rs2916733 | G | A | rs2916733 | 21799462 | 2.00E-09 | NA | 2.74 | [1.96-3.83] | 67 Japanese ancestry cases; 203 Japanese ancestry controls | Japanese(270) | ALL(270) | ASN(270) | ALL(270) | Epirubicin-induced leukopenia | HPOID:0001882 | Leukopenia | DOID:615 | leukopenia | D007970 | Leukopenia | EFOID:0004233 | leukopenia | Leukopenia | rs2916733-C | Research Support, Non-U.S. Gov't | T,C | MCPH1 |
| 8 | 6352358 | rs1031309 | A | C | rs1031309 | 23648065 | 4.69E-05 | Dominant model | 1.93 | [1.35-2.76] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1031309-C | Research Support, Non-U.S. Gov't |
| 8 | 9313017 | rs6995907 | T | C | rs6995907 | 23648065 | 6.88E-05 | Dominant model | 2 | [1.41-2.85] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6995907-T | Research Support, Non-U.S. Gov't |
| 8 | 9323515 | rs10105543 | C | T | rs10105543 | 23648065 | 6.56E-05 | Allelic model | 1.87 | [1.38-2.54] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10105543-C | Research Support, Non-U.S. Gov't |
| 8 | 10331754 | rs9329223 | A | G | rs9329223 | 23648065 | 7.02E-05 | Dominant model | 1.81 | [1.35-2.42] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9329223-A | Research Support, Non-U.S. Gov't |
| 8 | 11404514 | rs7820492 | G | A | rs7820492 | 23648065 | 9.01E-05 | Dominant model | 6.01 | [2.21-16.38] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7820492-T | Research Support, Non-U.S. Gov't |
| 8 | 11638244 | rs6601606 | A | G | rs6601606 | 21507922 | 1.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 8 | 14450366 | rs1510424 | A | G | rs1510424 | 23648065 | 6.75E-05 | Recessive model | 1.37 | [1.03-1.82] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1510424-A | Research Support, Non-U.S. Gov't |
| 8 | 15503648 | rs766472 | T | C | rs766472 | pha003095 | 8.14E-05 | phs000221 | phs000501 | 0.08 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs766472-G | NA |
| 8 | 15599492 | rs17121874 | C | T | rs17121874 | pha003095 | 9.89E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17121874-T | NA |
| 8 | 15636187 | rs12677979 | T | C | rs12677979 | pha003095 | 8.49E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs12677979-C | NA |
| 8 | 15646708 | rs17121980 | G | A | rs17121980 | pha003095 | 3.67E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17121980-A | NA |
| 8 | 16406371 | rs12681937 | G | T | rs12681937 | 23648065 | 8.67E-05 | Dominant model | 1.33 | [1.11-1.58] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12681937-T | Research Support, Non-U.S. Gov't |
| 8 | 17056651 | rs2904671 | G | A | rs2904671 | 23648065 | 3.26E-05 | Allelic model | 1.94 | [1.41-2.67] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2904671-A | Research Support, Non-U.S. Gov't |
| 8 | 18233582 | rs7006687 | C | T | rs7006687 | 23648065 | 6.63E-05 | Allelic model | 1.67 | [1.30-2.14] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7006687-T | Research Support, Non-U.S. Gov't |
| 8 | 18243603 | rs10109286 | T | C | rs10109286 | 23648065 | 3.33E-05 | Allelic model | 1.69 | [1.32-2.16] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10109286-C | Research Support, Non-U.S. Gov't |
| 8 | 18782047 | rs4921617 | C | T | rs4921617 | 21507922 | 4.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 8 | 18839091 | rs1426919 | A | C | rs1426919 | 23648065 | 9.51E-05 | Dominant model | 1.52 | [1.17-1.98] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1426919-C | Research Support, Non-U.S. Gov't |
| 8 | 18844382 | rs10216388 | C | A | rs10216388 | 23648065 | 9.87E-05 | Dominant model | 1.51 | [1.16-1.96] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10216388-G | Research Support, Non-U.S. Gov't |
| 8 | 21615817 | rs11786696 | C | T | rs11786696 | 23648065 | 8.26E-05 | Allelic model | 2.67 | [1.60-4.46] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11786696-G | Research Support, Non-U.S. Gov't |
| 8 | 22608029 | rs11781835 | A | G | rs11781835 | 23648065 | 9.16E-05 | Allelic model | 2.06 | [1.43-2.96] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11781835-T | Research Support, Non-U.S. Gov't |
| 8 | 26298209 | rs11781866 | T | C | rs11781866 | 23648065 | 1.11E-05 | Allelic model | 1.87 | [1.41-2.49] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11781866-T | Research Support, Non-U.S. Gov't |
| 8 | 26298209 | rs11781866 | T | C | rs11781866 | 23648065 | 8.16E-05 | Allelic model | 2.15 | [1.47-3.16] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11781866-T | Research Support, Non-U.S. Gov't |
| 8 | 27539370 | rs559251 | T | C | rs559251 | 23648065 | 1.17E-05 | Dominant model | 1.83 | [1.35-2.49] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs559251-T | Research Support, Non-U.S. Gov't |
| 8 | 27740066 | rs6999359 | G | A | rs6999359 | 23648065 | 1.68E-05 | Dominant model | 1.62 | [1.26-2.10] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6999359-T | Research Support, Non-U.S. Gov't |
| 8 | 27740417 | rs11774576 | C | T | rs11774576 | 23648065 | 3.00E-06 | Dominant model | 1.7 | [1.31-2.21] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11774576-A | Research Support, Non-U.S. Gov't |
| 8 | 27740693 | rs10103507 | A | G | rs10103507 | 23648065 | 4.45E-06 | Dominant model | 1.68 | [1.29-2.19] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10103507-G | Research Support, Non-U.S. Gov't |
| 8 | 29838800 | rs16876298 | G | A | rs16876298 | 23648065 | 1.96E-05 | Dominant model | 1.68 | [1.24-2.27] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16876298-C | Research Support, Non-U.S. Gov't |
| 8 | 33806910 | rs11780927 | G | A | rs11780927 | pha003095 | 3.66E-05 | phs000221 | phs000501 | 0.29 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11780927-A | NA |
| 8 | 33853868 | rs7465297 | G | A | rs7465297 | pha003095 | 3.70E-06 | phs000221 | phs000501 | 0.29 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7465297-G | NA |
| 8 | 33936891 | rs10954951 | A | G | rs10954951 | pha003095 | 5.76E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10954951-G | NA |
| 8 | 33955849 | rs7818248 | G | A | rs7818248 | pha003095 | 7.27E-06 | phs000221 | phs000501 | 0.29 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7818248-A | NA |
| 8 | 37118078 | rs6468400 | T | G | rs6468400 | 23648065 | 9.85E-05 | Dominant model | 1.5 | [1.18-1.91] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6468400-A | Research Support, Non-U.S. Gov't |
| 8 | 37660948 | rs4976893 | G | A | rs4976893 | 23648065 | 6.46E-05 | Recessive model | 1.35 | [1.14-1.61] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4976893-C | Research Support, Non-U.S. Gov't |
| 8 | 55779565 | rs1396895 | T | C | rs1396895 | 23648065 | 2.26E-05 | Recessive model | 1.49 | [0.99-2.25] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1396895-T | Research Support, Non-U.S. Gov't |
| 8 | 61056493 | rs2681543 | T | G | rs2681543 | pha003095 | 6.92E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2681543-T | NA |
| 8 | 61057832 | rs2611339 | G | T | rs2611339 | pha003095 | 6.92E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2611339-G | NA |
| 8 | 63915482 | rs16930073 | G | A | rs16930073 | 23648065 | 9.67E-05 | Allelic model | 1.46 | [1.21-1.77] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16930073-A | Research Support, Non-U.S. Gov't |
| 8 | 68527890 | rs900114 | G | T | rs900114 | 23648065 | 6.72E-05 | Dominant model | 1.78 | [1.29-2.45] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs900114-T | Research Support, Non-U.S. Gov't |
| 8 | 69119721 | rs9792403 | T | C | rs9792403 | 23648065 | 4.34E-05 | Recessive model | 1.31 | [0.92-1.87] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9792403-G | Research Support, Non-U.S. Gov't |
| 8 | 69119721 | rs9792403 | T | C | rs9792403 | 23648065 | 6.71E-05 | Recessive model | 1.31 | [0.84-2.06] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9792403-G | Research Support, Non-U.S. Gov't |
| 8 | 71449445 | rs10106858 | T | C | rs10106858 | 23648065 | 9.80E-05 | Recessive model | 1.37 | [0.92-2.05] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10106858-T | Research Support, Non-U.S. Gov't |
| 8 | 71454529 | rs4556114 | G | A | rs4556114 | 23648065 | 9.80E-05 | Recessive model | 1.35 | [0.90-2.02] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4556114-G | Research Support, Non-U.S. Gov't |
| 8 | 73702832 | rs1866739 | G | A | rs1866739 | 23648065 | 6.95E-05 | Allelic model | 2.54 | [1.59-4.07] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1866739-G | Research Support, Non-U.S. Gov't |
| 8 | 74230223 | rs6989495 | G | T | rs6989495 | 23648065 | 1.65E-05 | Recessive model | 1.69 | [1.31-2.19] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6989495-A | Research Support, Non-U.S. Gov't |
| 8 | 74230223 | rs6989495 | G | T | rs6989495 | 23648065 | 6.08E-05 | Recessive model | 1.57 | [1.22-2.01] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6989495-A | Research Support, Non-U.S. Gov't |
| 8 | 81470120 | rs272594 | A | C | rs272594 | 21507922 | 1.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 8 | 98080225 | rs2513399 | A | C | rs2513399 | 23648065 | 5.66E-05 | Allelic model | 2.49 | [1.59-3.89] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2513399-C | Research Support, Non-U.S. Gov't |
| 8 | 98260909 | rs17739295 | G | A | rs17739295 | pha003095 | 8.88E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17739295-A | NA |
| 8 | 98963817 | rs897189 | C | T | rs897189 | 23648065 | 5.58E-05 | Allelic model | 1.48 | [1.22-1.79] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs897189-A | Research Support, Non-U.S. Gov't |
| 8 | 98969239 | rs2512032 | T | G | rs2512032 | 23648065 | 4.78E-05 | Allelic model | 1.49 | [1.23-1.81] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2512032-C | Research Support, Non-U.S. Gov't |
| 8 | 98969239 | rs2512032 | T | G | rs2512032 | 23648065 | 7.93E-05 | Dominant model | 1.72 | [1.31-2.27] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2512032-C | Research Support, Non-U.S. Gov't |
| 8 | 99022009 | rs2444896 | C | A | rs2444896 | 23648065 | 2.00E-06 | Dominant model | 1.75 | [1.36-2.27] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2444896-T | Research Support, Non-U.S. Gov't |
| 8 | 101024505 | rs7006527 | A | C | rs7006527 | 23648065 | 4.57E-05 | Allelic model | 3.81 | [2.04-7.11] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7006527-G | Research Support, Non-U.S. Gov't |
| 8 | 101043237 | rs11779445 | T | C | rs11779445 | 23648065 | 6.11E-05 | Recessive model | 2.09 | [1.45-3.01] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11779445-C | Research Support, Non-U.S. Gov't |
| 8 | 101671221 | rs7002825 | T | C | rs7002825 | 23648065 | 2.95E-05 | Recessive model | 1.23 | [1.02-1.48] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7002825-A | Research Support, Non-U.S. Gov't |
| 8 | 101671221 | rs7002825 | T | C | rs7002825 | 23648065 | 7.44E-05 | Recessive model | 1.27 | [0.98-1.66] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7002825-A | Research Support, Non-U.S. Gov't |
| 8 | 108383641 | rs1672195 | T | C | rs1672195 | pha003095 | 6.53E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1672195-T | NA |
| 8 | 108385748 | rs1654712 | G | A | rs1654712 | pha003095 | 6.53E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1654712-G | NA |
| 8 | 108387747 | rs1672184 | A | G | rs1672184 | pha003095 | 1.37E-05 | phs000221 | phs000501 | 0.29 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1672184-A | NA |
| 8 | 109924310 | rs12681052 | C | A | rs12681052 | 23648065 | 3.66E-05 | Allelic model | 2.41 | [1.56-3.71] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12681052-C | Research Support, Non-U.S. Gov't |
| 8 | 114822319 | rs11998298 | G | T | rs11998298 | pha003095 | 5.01E-05 | phs000221 | phs000501 | 0.47 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11998298-T | NA |
| 8 | 117462506 | rs13263375 | T | C | rs13263375 | 23648065 | 1.81E-05 | Allelic model | 1.53 | [1.26-1.87] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13263375-T | Research Support, Non-U.S. Gov't |
| 8 | 117462992 | rs13270180 | G | A | rs13270180 | 23648065 | 2.21E-05 | Allelic model | 1.53 | [1.25-1.86] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13270180-G | Research Support, Non-U.S. Gov't |
| 8 | 121377780 | rs7821312 | C | T | rs7821312 | 23648065 | 3.83E-05 | Allelic model | 1.58 | [1.27-1.95] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7821312-A | Research Support, Non-U.S. Gov't |
| 8 | 121377780 | rs7821312 | C | T | rs7821312 | 23648065 | 4.26E-05 | Allelic model | 2.38 | [1.56-3.63] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7821312-A | Research Support, Non-U.S. Gov't |
| 8 | 121386925 | rs4870728 | C | T | rs4870728 | 23648065 | 5.20E-05 | Allelic model | 1.56 | [1.26-1.92] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4870728-T | Research Support, Non-U.S. Gov't |
| 8 | 126380443 | rs4871589 | T | C | rs4871589 | 23648065 | 5.77E-05 | Dominant model | 1.63 | [1.23-2.15] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4871589-G | Research Support, Non-U.S. Gov't |
| 8 | 135870334 | rs1000394 | T | C | rs1000394 | 23648065 | 8.48E-05 | Recessive model | 1.37 | [0.92-2.04] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1000394-A | Research Support, Non-U.S. Gov't |
| 8 | 135870334 | rs1000394 | T | C | rs1000394 | 23648065 | 9.24E-05 | Recessive model | 1.98 | [1.23-3.19] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1000394-A | Research Support, Non-U.S. Gov't |
| 8 | 136522558 | rs11779943 | G | A | rs11779943 | 23648065 | 6.61E-05 | Recessive model | 1.43 | [1.00-2.06] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11779943-C | Research Support, Non-U.S. Gov't |
| 8 | 136526248 | rs10092358 | A | G | rs10092358 | 23648065 | 6.61E-05 | Recessive model | 1.43 | [1.00-2.06] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10092358-T | Research Support, Non-U.S. Gov't |
| 8 | 136539132 | rs16905387 | T | G | rs16905387 | 23648065 | 4.23E-05 | Recessive model | 1.47 | [1.03-2.09] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16905387-A | Research Support, Non-U.S. Gov't |
| 8 | 136624184 | rs11166605 | A | G | rs11166605 | 23648065 | 4.23E-05 | Recessive model | 1.47 | [1.02-2.09] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11166605-A | Research Support, Non-U.S. Gov't |
| 8 | 145677011 | rs2721195 | T | C | rs2721195 | 23648065 | 8.99E-05 | Dominant model | 1.95 | [1.38-2.75] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2721195-G | Research Support, Non-U.S. Gov't |
| 8 | 145701453 | rs750472 | A | C | rs750472 | 23648065 | 8.99E-05 | Dominant model | 1.93 | [1.37-2.73] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs750472-G | Research Support, Non-U.S. Gov't |
| 9 | 4096451 | rs806034 | G | T | rs806034 | pha003095 | 3.21E-05 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs806034-T | NA |
| 9 | 4096642 | rs806033 | C | A | rs806033 | pha003095 | 3.04E-05 | phs000221 | phs000501 | 0.34 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs806033-A | NA |
| 9 | 8737316 | rs6477333 | A | G | rs6477333 | 23648065 | 2.98E-05 | Dominant model | 2.52 | [1.57-4.03] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6477333-A | Research Support, Non-U.S. Gov't |
| 9 | 8922089 | rs10977361 | G | A | rs10977361 | pha003095 | 6.38E-05 | phs000221 | phs000501 | 0.36 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10977361-A | NA |
| 9 | 10270339 | rs2475357 | T | G | rs2475357 | 23648065 | 6.10E-05 | Recessive model | 1.33 | [1.12-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2475357-C | Research Support, Non-U.S. Gov't |
| 9 | 10546257 | rs2181158 | G | T | rs2181158 | 23648065 | 7.13E-05 | Allelic model | 1.78 | [1.34-2.36] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2181158-A | Research Support, Non-U.S. Gov't |
| 9 | 10561180 | rs10756061 | T | C | rs10756061 | 23648065 | 7.97E-05 | Allelic model | 1.75 | [1.33-2.30] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10756061-G | Research Support, Non-U.S. Gov't |
| 9 | 10586527 | rs13298283 | A | C | rs13298283 | 23648065 | 2.55E-05 | Dominant model | 1.89 | [1.41-2.54] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13298283-G | Research Support, Non-U.S. Gov't |
| 9 | 11101956 | rs7044787 | G | A | rs7044787 | 23648065 | 8.45E-05 | Allelic model | 1.97 | [1.38-2.82] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7044787-C | Research Support, Non-U.S. Gov't |
| 9 | 11606348 | rs10511567 | T | C | rs10511567 | 23648065 | 1.30E-05 | Dominant model | 1.72 | [1.30-2.29] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10511567-C | Research Support, Non-U.S. Gov't |
| 9 | 15059821 | rs7040444 | G | T | rs7040444 | 23648065 | 4.77E-05 | Recessive model | 1.54 | [1.11-2.15] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7040444-A | Research Support, Non-U.S. Gov't |
| 9 | 16349953 | rs4961706 | G | T | rs4961706 | 23648065 | 2.63E-05 | Allelic model | 2.07 | [1.47-2.91] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4961706-G | Research Support, Non-U.S. Gov't |
| 9 | 18127068 | rs10810904 | A | G | rs10810904 | 23648065 | 6.29E-05 | Dominant model | 2.25 | [1.53-3.32] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10810904-C | Research Support, Non-U.S. Gov't |
| 9 | 19033058 | rs10963922 | C | A | rs10963922 | 23648065 | 8.43E-05 | Dominant model | 1.24 | [1.04-1.48] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10963922-A | Research Support, Non-U.S. Gov't |
| 9 | 26205694 | rs2217796 | A | G | rs2217796 | 23648065 | 3.65E-05 | Allelic model | 2.24 | [1.55-3.25] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2217796-G | Research Support, Non-U.S. Gov't |
| 9 | 27546890 | rs13691 | G | A | rs13691 | 23648065 | 6.33E-05 | Recessive model | 1.8 | [1.15-2.81] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13691-A | Research Support, Non-U.S. Gov't |
| 9 | 30413575 | rs12351836 | G | A | rs12351836 | 23648065 | 2.66E-05 | Allelic model | 2.08 | [1.48-2.93] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12351836-A | Research Support, Non-U.S. Gov't |
| 9 | 30467137 | rs10813259 | A | G | rs10813259 | 23648065 | 5.24E-05 | Dominant model | 1.71 | [1.29-2.27] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10813259-T | Research Support, Non-U.S. Gov't |
| 9 | 30591737 | rs1104787 | G | A | rs1104787 | 23648065 | 6.92E-05 | Dominant model | 2.22 | [1.47-3.34] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1104787-G | Research Support, Non-U.S. Gov't |
| 9 | 31977623 | rs1038268 | A | G | rs1038268 | 23648065 | 4.73E-05 | Allelic model | 2.33 | [1.53-3.54] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1038268-C | Research Support, Non-U.S. Gov't |
| 9 | 31989998 | rs2375811 | A | G | rs2375811 | 23648065 | 3.17E-05 | Allelic model | 2.38 | [1.57-3.63] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2375811-G | Research Support, Non-U.S. Gov't |
| 9 | 32007381 | rs201642778 | T | TG,TT | rs2375814 | 23648065 | 8.30E-05 | Dominant model | 2.32 | [1.51-3.56] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2375814-C | Research Support, Non-U.S. Gov't |
| 9 | 32007381 | rs2375814 | T | G | rs2375814 | 23648065 | 8.30E-05 | Dominant model | 2.32 | [1.51-3.56] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2375814-C | Research Support, Non-U.S. Gov't |
| 9 | 34978431 | rs3739873 | G | A | rs3739873 | 23648065 | 8.19E-05 | Recessive model | 1.52 | [1.20-1.94] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3739873-C | Research Support, Non-U.S. Gov't |
| 9 | 35648950 | rs3138083 | A | G | rs3138083 | 23648065 | 4.00E-06 | Allelic model | 2.14 | [1.55-2.94] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3138083-A | Research Support, Non-U.S. Gov't |
| 9 | 38380350 | rs4878797 | C | A | rs4878797 | 23648065 | 8.84E-05 | Allelic model | 2.1 | [1.44-3.06] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4878797-G | Research Support, Non-U.S. Gov't |
| 9 | 79236165 | rs786320 | G | A | rs786320 | 23648065 | 6.83E-05 | Recessive model | 1.83 | [1.16-2.89] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs786320-C | Research Support, Non-U.S. Gov't |
| 9 | 80181751 | rs7849646 | C | T | rs7849646 | 23648065 | 7.92E-05 | Recessive model | 1.39 | [1.16-1.66] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7849646-A | Research Support, Non-U.S. Gov't |
| 9 | 87844016 | rs11140900 | C | T | rs11140900 | 23648065 | 2.95E-05 | Recessive model | 1.42 | [1.05-1.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11140900-T | Research Support, Non-U.S. Gov't |
| 9 | 87845035 | rs11140902 | C | T | rs11140902 | 23648065 | 9.50E-05 | Recessive model | 1.43 | [1.06-1.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11140902-A | Research Support, Non-U.S. Gov't |
| 9 | 88847477 | rs942284 | C | T | rs942284 | 23648065 | 2.42E-05 | Dominant model | 1.91 | [1.24-2.96] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs942284-G | Research Support, Non-U.S. Gov't |
| 9 | 89191784 | rs10780771 | A | G | rs10780771 | 23648065 | 6.04E-05 | Recessive model | 1.35 | [1.10-1.65] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10780771-A | Research Support, Non-U.S. Gov't |
| 9 | 94414784 | rs2076773 | G | A | rs2076773 | 23648065 | 6.11E-05 | Dominant model | 2.26 | [1.55-3.29] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2076773-A | Research Support, Non-U.S. Gov't |
| 9 | 94414784 | rs2076773 | G | A | rs2076773 | 23648065 | 9.85E-05 | Dominant model | 4.91 | [2.18-11.06] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2076773-A | Research Support, Non-U.S. Gov't |
| 9 | 94420140 | rs7032274 | T | C | rs7032274 | 23648065 | 6.40E-05 | Dominant model | 1.42 | [1.13-1.78] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7032274-C | Research Support, Non-U.S. Gov't |
| 9 | 94420140 | rs7032274 | T | C | rs7032274 | 23648065 | 7.08E-05 | Dominant model | 1.29 | [1.09-1.53] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7032274-C | Research Support, Non-U.S. Gov't |
| 9 | 114780290 | rs10981210 | T | C | rs10981210 | 23648065 | 4.87E-05 | Dominant model | 1.88 | [1.28-2.76] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10981210-G | Research Support, Non-U.S. Gov't |
| 9 | 114981378 | rs14255 | T | G | rs14255 | 23648065 | 3.07E-05 | Allelic model | 1.54 | [1.26-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs14255-T | Research Support, Non-U.S. Gov't |
| 9 | 114989616 | rs6477900 | A | G | rs6477900 | 23648065 | 1.46E-05 | Allelic model | 1.56 | [1.28-1.90] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6477900-A | Research Support, Non-U.S. Gov't |
| 9 | 115039845 | rs7875779 | T | C | rs7875779 | 23648065 | 1.86E-05 | Allelic model | 1.55 | [1.27-1.89] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7875779-T | Research Support, Non-U.S. Gov't |
| 9 | 115088669 | rs4542000 | T | C | rs4542000 | 23648065 | 1.38E-05 | Allelic model | 1.56 | [1.28-1.90] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4542000-T | Research Support, Non-U.S. Gov't |
| 9 | 115095743 | rs7040447 | T | C | rs7040447 | 23648065 | 1.37E-05 | Allelic model | 1.56 | [1.28-1.90] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7040447-A | Research Support, Non-U.S. Gov't |
| 9 | 116125789 | rs10981769 | T | C | rs10981769 | 23648065 | 3.50E-05 | Allelic model | 4.31 | [2.13-8.76] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10981769-A | Research Support, Non-U.S. Gov't |
| 9 | 118433442 | rs10817809 | T | C | rs10817809 | 23648065 | 2.25E-05 | Allelic model | 2.1 | [1.49-2.96] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10817809-T | Research Support, Non-U.S. Gov't |
| 9 | 118451241 | rs10817817 | A | G | rs10817817 | 23648065 | 3.18E-05 | Allelic model | 2.08 | [1.48-2.93] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10817817-T | Research Support, Non-U.S. Gov't |
| 9 | 118475932 | rs12380012 | C | T | rs12380012 | 23648065 | 2.40E-05 | Allelic model | 2.09 | [1.48-2.94] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12380012-G | Research Support, Non-U.S. Gov't |
| 9 | 120035769 | rs6478300 | C | A | rs6478300 | 23648065 | 1.32E-05 | Dominant model | 1.54 | [1.20-1.96] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6478300-C | Research Support, Non-U.S. Gov't |
| 9 | 120054021 | rs7862566 | C | T | rs7862566 | 23648065 | 3.15E-05 | Recessive model | 1.65 | [1.25-2.18] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7862566-C | Research Support, Non-U.S. Gov't |
| 9 | 120054021 | rs7862566 | C | T | rs7862566 | 23648065 | 5.72E-05 | Recessive model | 1.44 | [1.12-1.86] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7862566-C | Research Support, Non-U.S. Gov't |
| 9 | 120277096 | rs549493 | T | C | rs549493 | pha003095 | 4.73E-05 | phs000221 | phs000501 | 0.37 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs549493-C | NA |
| 9 | 121452706 | rs10984174 | G | A | rs10984174 | 23648065 | 6.30E-05 | Dominant model | 1.38 | [1.12-1.70] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10984174-T | Research Support, Non-U.S. Gov't |
| 9 | 124521260 | rs3747851 | G | A | rs3747851 | 23648065 | 6.00E-07 | Allelic model | 2.38 | [1.69-3.34] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3747851-T | Research Support, Non-U.S. Gov't |
| 9 | 126304553 | rs10513428 | C | T | rs10513428 | 23648065 | 8.87E-05 | Dominant model | 3.13 | [1.79-5.47] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10513428-T | Research Support, Non-U.S. Gov't |
| 9 | 126855342 | rs7858299 | G | T | rs7858299 | 23648065 | 5.69E-05 | Allelic model | 1.91 | [1.38-2.64] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7858299-C | Research Support, Non-U.S. Gov't |
| 9 | 126860775 | rs7860363 | C | T | rs7860363 | 23648065 | 6.73E-05 | Allelic model | 1.91 | [1.38-2.65] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7860363-G | Research Support, Non-U.S. Gov't |
| 9 | 126862478 | rs7868364 | G | T | rs7868364 | 23648065 | 7.47E-05 | Allelic model | 1.88 | [1.36-2.61] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7868364-G | Research Support, Non-U.S. Gov't |
| 9 | 131960870 | rs2417135 | C | T | rs2417135 | 23648065 | 4.08E-05 | Allelic model | 9.92 | [2.31-42.53] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2417135-G | Research Support, Non-U.S. Gov't |
| 9 | 133629184 | rs4740363 | A | G | rs4740363 | pha003095 | 9.30E-05 | phs000221 | phs000501 | 0.43 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4740363-G | NA |
| 9 | 133630622 | rs4740366 | A | G | rs4740366 | pha003095 | 9.84E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4740366-G | NA |
| 9 | 133636808 | rs4740203 | C | T | rs4740203 | pha003095 | 4.23E-05 | phs000221 | phs000501 | 0.31 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4740203-T | NA |
| 9 | 135139826 | rs3739927 | T | C | rs3739927 | 23648065 | 8.25E-05 | Dominant model | 1.58 | [1.24-2.02] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3739927-C | Research Support, Non-U.S. Gov't |
| 9 | 136454105 | rs28666751 | C | T | rs28666751 | 23648065 | 8.49E-05 | Dominant model | 1.78 | [1.26-2.51] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs28666751-T | Research Support, Non-U.S. Gov't |
| 9 | 137098042 | rs7872110 | T | C | rs7872110 | 23648065 | 8.70E-05 | Allelic model | 2.23 | [1.48-3.37] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7872110-G | Research Support, Non-U.S. Gov't |
| 9 | 137120661 | rs7848481 | T | C | rs7848481 | 23648065 | 8.60E-05 | Allelic model | 2.18 | [1.47-3.24] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7848481-C | Research Support, Non-U.S. Gov't |
| 9 | 137125501 | rs10785877 | G | A | rs10785877 | 23648065 | 7.00E-07 | Allelic model | 2.58 | [1.77-3.77] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10785877-T | Research Support, Non-U.S. Gov't |
| 9 | 139535714 | rs10735657 | G | T | rs10735657 | 23648065 | 1.92E-05 | Recessive model | 1.53 | [1.21-1.93] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10735657-C | Research Support, Non-U.S. Gov't |
| 9 | 139544437 | rs7871194 | A | C | rs7871194 | 23648065 | 3.83E-05 | Recessive model | 1.41 | [1.18-1.69] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7871194-A | Research Support, Non-U.S. Gov't |
| 10 | 2027751 | rs7915592 | C | T | rs7915592 | 23648065 | 6.38E-05 | Dominant model | 2.62 | [1.44-4.77] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7915592-G | Research Support, Non-U.S. Gov't |
| 10 | 2291522 | rs11817443 | T | C | rs11817443 | 23648065 | 2.66E-05 | Allelic model | 4.35 | [2.13-8.89] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11817443-G | Research Support, Non-U.S. Gov't |
| 10 | 2351833 | rs768628 | T | C | rs768628 | 23648065 | 6.52E-05 | Dominant model | 3.34 | [1.82-6.11] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs768628-C | Research Support, Non-U.S. Gov't |
| 10 | 3949166 | rs9651513 | G | A | rs9651513 | 23648065 | 9.90E-05 | Dominant model | 1.36 | [1.14-1.63] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9651513-G | Research Support, Non-U.S. Gov't |
| 10 | 4380623 | rs4261192 | G | T | rs4261192 | 23648065 | 5.97E-05 | Recessive model | 1.55 | [1.04-2.32] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4261192-C | Research Support, Non-U.S. Gov't |
| 10 | 4382152 | rs10795158 | T | C | rs10795158 | 23648065 | 5.97E-05 | Recessive model | 1.55 | [1.04-2.32] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10795158-T | Research Support, Non-U.S. Gov't |
| 10 | 4384056 | rs9633757 | C | T | rs9633757 | 23648065 | 5.88E-05 | Recessive model | 1.59 | [1.06-2.37] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9633757-A | Research Support, Non-U.S. Gov't |
| 10 | 4390097 | rs11252477 | A | G | rs11252477 | 23648065 | 5.88E-05 | Recessive model | 1.79 | [1.19-2.70] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11252477-G | Research Support, Non-U.S. Gov't |
| 10 | 7259446 | rs2692840 | C | T | rs2692840 | 23648065 | 3.98E-05 | Dominant model | 18.59 | [2.44-141.40] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2692840-C | Research Support, Non-U.S. Gov't |
| 10 | 7265468 | rs2692812 | T | C | rs2692812 | 23648065 | 3.98E-05 | Dominant model | 18.59 | [2.44-141.40] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2692812-A | Research Support, Non-U.S. Gov't |
| 10 | 7276215 | rs10905124 | G | A | rs10905124 | 23648065 | 3.41E-05 | Dominant model | 19.02 | [2.50-144.80] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10905124-C | Research Support, Non-U.S. Gov't |
| 10 | 7280550 | rs10905129 | T | C | rs10905129 | 23648065 | 3.98E-05 | Dominant model | 18.59 | [2.44-141.40] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10905129-T | Research Support, Non-U.S. Gov't |
| 10 | 8545524 | rs10795650 | A | G | rs10795650 | 23648065 | 4.54E-05 | Dominant model | 1.63 | [1.27-2.09] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10795650-C | Research Support, Non-U.S. Gov't |
| 10 | 11394809 | rs3847424 | A | G | rs3847424 | 23648065 | 6.17E-05 | Allelic model | 2.21 | [1.50-3.27] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3847424-A | Research Support, Non-U.S. Gov't |
| 10 | 11396152 | rs12245515 | G | A | rs12245515 | 23648065 | 6.17E-05 | Allelic model | 2.21 | [1.50-3.27] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12245515-G | Research Support, Non-U.S. Gov't |
| 10 | 11491077 | rs1530375 | C | T | rs1530375 | 23648065 | 1.50E-05 | Allelic model | 1.8 | [1.37-2.36] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1530375-A | Research Support, Non-U.S. Gov't |
| 10 | 11671268 | rs7094839 | T | G | rs7094839 | 23648065 | 6.75E-05 | Allelic model | 1.92 | [1.38-2.66] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7094839-T | Research Support, Non-U.S. Gov't |
| 10 | 12959026 | rs281849 | G | T | rs281849 | 23648065 | 3.24E-05 | Dominant model | 17.95 | [2.38-135.60] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs281849-T | Research Support, Non-U.S. Gov't |
| 10 | 13000495 | rs13377047 | G | A | rs13377047 | 23648065 | 4.10E-05 | Recessive model | 1.37 | [1.07-1.74] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13377047-A | Research Support, Non-U.S. Gov't |
| 10 | 20674653 | rs12772794 | A | G | rs12772794 | 21507922 | 7.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 10 | 25144730 | rs10741068 | C | T | rs10741068 | 23648065 | 9.09E-05 | Dominant model | 2.11 | [1.44-3.08] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10741068-G | Research Support, Non-U.S. Gov't |
| 10 | 25459750 | rs11014431 | A | G | rs11014431 | 23648065 | 5.19E-05 | Recessive model | 1.43 | [1.20-1.71] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11014431-T | Research Support, Non-U.S. Gov't |
| 10 | 25459750 | rs11014431 | A | G | rs11014431 | 23648065 | 7.34E-05 | Recessive model | 1.64 | [1.26-2.15] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11014431-T | Research Support, Non-U.S. Gov't |
| 10 | 25531636 | rs915028 | A | C | rs915028 | 23648065 | 8.64E-05 | Allelic model | 1.69 | [1.30-2.20] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs915028-A | Research Support, Non-U.S. Gov't |
| 10 | 25532099 | rs1339999 | C | T | rs1339999 | 23648065 | 1.70E-05 | Allelic model | 1.79 | [1.37-2.35] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1339999-C | Research Support, Non-U.S. Gov't |
| 10 | 25532099 | rs1339999 | C | T | rs1339999 | 23648065 | 7.82E-05 | Allelic model | 1.43 | [1.20-1.72] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1339999-C | Research Support, Non-U.S. Gov't |
| 10 | 25533536 | rs1416995 | T | C | rs1416995 | 23648065 | 5.31E-05 | Allelic model | 1.71 | [1.31-2.22] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1416995-T | Research Support, Non-U.S. Gov't |
| 10 | 25576492 | rs7902135 | G | A | rs7902135 | 23648065 | 5.56E-05 | Allelic model | 1.7 | [1.31-2.21] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7902135-G | Research Support, Non-U.S. Gov't |
| 10 | 28734355 | rs7085106 | C | T | rs7085106 | 23648065 | 5.94E-05 | Dominant model | 3.15 | [1.74-5.69] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7085106-T | Research Support, Non-U.S. Gov't |
| 10 | 29056628 | rs787111 | C | A | rs787111 | 23648065 | 3.26E-05 | Dominant model | 4.32 | [2.10-8.87] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs787111-A | Research Support, Non-U.S. Gov't |
| 10 | 30099778 | rs2986974 | A | G | rs2986974 | 23648065 | 9.51E-05 | Dominant model | 1.58 | [1.20-2.08] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2986974-G | Research Support, Non-U.S. Gov't |
| 10 | 30639220 | rs11008005 | A | G | rs11008005 | 23648065 | 7.19E-05 | Recessive model | 1.62 | [1.21-2.17] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11008005-A | Research Support, Non-U.S. Gov't |
| 10 | 32044641 | rs2778646 | A | C | rs2778646 | 23648065 | 3.73E-05 | Allelic model | 2.37 | [1.56-3.61] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2778646-G | Research Support, Non-U.S. Gov't |
| 10 | 44911999 | rs11239035 | C | T | rs11239035 | 23648065 | 7.13E-05 | Dominant model | 3.94 | [1.93-8.03] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11239035-G | Research Support, Non-U.S. Gov't |
| 10 | 48471020 | rs12414155 | T | C | rs12414155 | 23648065 | 6.59E-05 | Recessive model | 1.25 | [1.06-1.49] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12414155-G | Research Support, Non-U.S. Gov't |
| 10 | 49930541 | rs17781278 | G | A | rs17781278 | 23648065 | 6.32E-05 | Dominant model | 4.62 | [1.81-11.74] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17781278-A | Research Support, Non-U.S. Gov't |
| 10 | 51570152 | rs10740051 | G | A | rs10740051 | 23648065 | 9.45E-05 | Dominant model | 1.61 | [1.26-2.05] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10740051-A | Research Support, Non-U.S. Gov't |
| 10 | 52370312 | rs4935737 | T | G | rs4935737 | pha003095 | 8.41E-05 | phs000221 | phs000501 | 0.2 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4935737-G | NA |
| 10 | 54715100 | rs10824843 | A | G | rs10824843 | 23648065 | 2.44E-05 | Allelic model | 2.1 | [1.48-2.97] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10824843-A | Research Support, Non-U.S. Gov't |
| 10 | 55955444 | rs4935502 | T | G | rs4935502 | 23648065 | 3.62E-05 | Dominant model | 2.69 | [1.64-4.39] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4935502-T | Research Support, Non-U.S. Gov't |
| 10 | 61113993 | rs284609 | G | A | rs284609 | 23648065 | 8.68E-05 | Recessive model | 1.26 | [0.90-1.78] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs284609-A | Research Support, Non-U.S. Gov't |
| 10 | 61820631 | rs7893313 | T | C | rs7893313 | 23648065 | 1.01E-05 | Recessive model | 1.36 | [1.15-1.61] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7893313-T | Research Support, Non-U.S. Gov't |
| 10 | 61902023 | rs2288359 | T | C | rs2288359 | 23648065 | 3.64E-05 | Dominant model | 1.89 | [1.39-2.58] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2288359-T | Research Support, Non-U.S. Gov't |
| 10 | 64260847 | rs12245332 | T | C | rs12245332 | 23648065 | 2.03E-05 | Dominant model | 1.9 | [1.35-2.67] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12245332-G | Research Support, Non-U.S. Gov't |
| 10 | 71052508 | rs10762277 | G | A | rs10762277 | 23648065 | 8.23E-05 | Dominant model | 1.91 | [1.31-2.80] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10762277-G | Research Support, Non-U.S. Gov't |
| 10 | 71376076 | rs1903791 | C | T | rs1903791 | pha003095 | 5.49E-05 | phs000221 | phs000501 | 0.31 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1903791-T | NA |
| 10 | 72331540 | rs10762393 | A | G | rs10762393 | 23648065 | 2.43E-05 | Dominant model | 4 | [1.85-8.64] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10762393-A | Research Support, Non-U.S. Gov't |
| 10 | 72343117 | rs10823577 | T | C | rs10823577 | pha003095 | 3.31E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10823577-T | NA |
| 10 | 74182400 | rs11000295 | G | A | rs11000295 | 23648065 | 4.38E-05 | Allelic model | 2.47 | [1.62-3.78] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11000295-A | Research Support, Non-U.S. Gov't |
| 10 | 74183251 | rs7069357 | G | A | rs7069357 | 23648065 | 4.46E-05 | Allelic model | 2.46 | [1.61-3.77] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7069357-A | Research Support, Non-U.S. Gov't |
| 10 | 74204929 | rs1004256 | G | A | rs1004256 | 23648065 | 4.38E-05 | Allelic model | 2.47 | [1.62-3.78] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1004256-A | Research Support, Non-U.S. Gov't |
| 10 | 74224647 | rs4561121 | C | T | rs4561121 | 23648065 | 4.38E-05 | Allelic model | 2.47 | [1.62-3.78] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4561121-T | Research Support, Non-U.S. Gov't |
| 10 | 74482123 | rs3009547 | T | C | rs3009547 | 23648065 | 9.08E-05 | Allelic model | 2.36 | [1.55-3.59] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3009547-G | Research Support, Non-U.S. Gov't |
| 10 | 76540987 | rs3862556 | C | T | rs3862556 | 23648065 | 8.47E-05 | Allelic model | 1.83 | [1.36-2.46] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3862556-A | Research Support, Non-U.S. Gov't |
| 10 | 76643827 | rs11001192 | G | A | rs11001192 | 23648065 | 8.58E-05 | Allelic model | 3.02 | [1.73-5.26] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11001192-A | Research Support, Non-U.S. Gov't |
| 10 | 76685101 | rs11001204 | A | G | rs11001204 | 23648065 | 6.41E-05 | Allelic model | 3.16 | [1.80-5.56] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11001204-C | Research Support, Non-U.S. Gov't |
| 10 | 79525505 | rs11002284 | C | T | rs11002284 | 23648065 | 8.33E-05 | Recessive model | 1.37 | [1.07-1.75] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11002284-T | Research Support, Non-U.S. Gov't |
| 10 | 83602560 | rs2207657 | T | C | rs2207657 | 23648065 | 8.22E-05 | Allelic model | 1.42 | [1.19-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2207657-T | Research Support, Non-U.S. Gov't |
| 10 | 83608508 | rs10883825 | T | C | rs10883825 | 23648065 | 3.43E-05 | Allelic model | 1.43 | [1.21-1.70] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10883825-A | Research Support, Non-U.S. Gov't |
| 10 | 86004269 | rs10887261 | C | T | rs10887261 | pha003095 | 5.72E-05 | phs000221 | phs000501 | 0.38 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs10887261-T | NA |
| 10 | 92688298 | rs1539479 | A | G | rs1539479 | 23648065 | 1.72E-05 | Dominant model | 2.9 | [1.71-4.92] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1539479-T | Research Support, Non-U.S. Gov't |
| 10 | 92719584 | rs7099299 | C | T | rs7099299 | 23648065 | 8.76E-05 | Allelic model | 2.73 | [1.64-4.54] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7099299-G | Research Support, Non-U.S. Gov't |
| 10 | 92720630 | rs1334583 | A | G | rs1334583 | 23648065 | 8.75E-05 | Allelic model | 2.73 | [1.64-4.55] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1334583-A | Research Support, Non-U.S. Gov't |
| 10 | 92770051 | rs4933637 | A | C | rs4933637 | 23648065 | 2.97E-05 | Allelic model | 2.08 | [1.48-2.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4933637-C | Research Support, Non-U.S. Gov't |
| 10 | 92779580 | rs4933203 | T | C | rs4933203 | 23648065 | 6.94E-05 | Allelic model | 3.46 | [1.84-6.50] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4933203-T | Research Support, Non-U.S. Gov't |
| 10 | 103111057 | rs7916830 | T | C | rs7916830 | 23648065 | 8.13E-05 | Recessive model | 2.22 | [1.44-3.41] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7916830-A | Research Support, Non-U.S. Gov't |
| 10 | 103124457 | rs7090670 | A | C | rs7090670 | 23648065 | 8.64E-05 | Recessive model | 2.12 | [1.38-3.26] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7090670-A | Research Support, Non-U.S. Gov't |
| 10 | 103133249 | rs10450405 | T | C | rs10450405 | 23648065 | 8.13E-05 | Recessive model | 2.14 | [1.39-3.29] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10450405-A | Research Support, Non-U.S. Gov't |
| 10 | 103186838 | rs7901883 | G | A | rs7901883 | 23648065 | 8.13E-05 | Recessive model | 2.14 | [1.39-3.29] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7901883-G | Research Support, Non-U.S. Gov't |
| 10 | 107460228 | rs10509794 | T | C | rs10509794 | 23648065 | 8.48E-05 | Allelic model | 16.13 | [2.13-122.07] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10509794-A | Research Support, Non-U.S. Gov't |
| 10 | 107523565 | rs17119496 | T | C | rs17119496 | 23648065 | 7.67E-05 | Dominant model | 1.68 | [1.29-2.18] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17119496-C | Research Support, Non-U.S. Gov't |
| 10 | 117842360 | rs4751949 | C | T | rs4751949 | 23648065 | 5.27E-05 | Allelic model | 3.6 | [1.95-6.67] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4751949-G | Research Support, Non-U.S. Gov't |
| 10 | 121186001 | rs1889432 | A | G | rs1889432 | 23648065 | 7.69E-05 | Dominant model | 1.5 | [1.23-1.84] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1889432-G | Research Support, Non-U.S. Gov't |
| 10 | 121202677 | rs11198927 | G | A | rs11198927 | 23648065 | 9.67E-05 | Recessive model | 1.36 | [0.98-1.87] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11198927-A | Research Support, Non-U.S. Gov't |
| 10 | 124692586 | rs4980169 | A | G | rs4980169 | 23648065 | 9.56E-05 | Allelic model | 1.83 | [1.33-2.52] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4980169-G | Research Support, Non-U.S. Gov't |
| 10 | 126144839 | rs908366 | C | T | rs908366 | 23648065 | 7.00E-06 | Allelic model | 2.2 | [1.56-3.09] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs908366-A | Research Support, Non-U.S. Gov't |
| 10 | 126275914 | rs12773846 | G | A | rs12773846 | 23648065 | 1.30E-05 | Dominant model | 1.68 | [1.27-2.22] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12773846-C | Research Support, Non-U.S. Gov't |
| 10 | 127115598 | rs7897813 | G | A | rs7897813 | pha003095 | 8.42E-05 | phs000221 | phs000501 | 0.35 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7897813-A | NA |
| 10 | 127118333 | rs7896776 | T | C | rs7896776 | pha003095 | 8.26E-05 | phs000221 | phs000501 | 0.35 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs7896776-C | NA |
| 10 | 128141955 | rs4962558 | T | C | rs4962558 | 23648065 | 6.04E-05 | Allelic model | 2.44 | [1.54-3.87] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4962558-A | Research Support, Non-U.S. Gov't |
| 10 | 129713541 | rs11018401 | G | T | rs11018401 | 23648065 | 2.43E-05 | Dominant model | 2.79 | [1.71-4.56] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11018401-T | Research Support, Non-U.S. Gov't |
| 11 | 710139 | rs7942569 | G | A | rs7942569 | 23648065 | 6.07E-05 | Allelic model | 2.46 | [1.59-3.83] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7942569-A | Research Support, Non-U.S. Gov't |
| 11 | 1941946 | rs909116 | T | C | rs909116 | 23648065 | 9.63E-05 | Allelic model | 3.43 | [1.86-6.30] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs909116-G | Research Support, Non-U.S. Gov't |
| 11 | 4406483 | rs2269330 | A | G | rs2269330 | 23648065 | 9.05E-05 | Recessive model | 1.46 | [1.07-1.99] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2269330-A | Research Support, Non-U.S. Gov't |
| 11 | 5904497 | rs10500657 | T | C | rs10500657 | 23648065 | 3.56E-05 | Dominant model | 1.54 | [1.26-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10500657-T | Research Support, Non-U.S. Gov't |
| 11 | 5906048 | rs4758168 | G | A | rs4758168 | 23648065 | 3.57E-05 | Dominant model | 1.54 | [1.26-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4758168-G | Research Support, Non-U.S. Gov't |
| 11 | 5906073 | rs4757986 | G | T | rs4757986 | 23648065 | 3.58E-05 | Dominant model | 1.54 | [1.26-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4757986-G | Research Support, Non-U.S. Gov't |
| 11 | 5906192 | rs1453435 | A | C | rs1453435 | 23648065 | 3.58E-05 | Dominant model | 1.54 | [1.26-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1453435-T | Research Support, Non-U.S. Gov't |
| 11 | 7696338 | rs12292013 | G | T | rs12292013 | 23648065 | 7.73E-05 | Dominant model | 5.88 | [2.08-16.63] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12292013-G | Research Support, Non-U.S. Gov't |
| 11 | 9389875 | rs4910048 | C | T | rs4910048 | 23648065 | 7.33E-05 | Dominant model | 1.54 | [1.19-1.99] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4910048-C | Research Support, Non-U.S. Gov't |
| 11 | 9825447 | rs6483726 | C | T | rs6483726 | 23648065 | 9.84E-05 | Recessive model | 1.32 | [0.91-1.93] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6483726-G | Research Support, Non-U.S. Gov't |
| 11 | 13625439 | rs1502243 | G | A | rs1502243 | 23648065 | 5.62E-05 | Allelic model | 1.8 | [1.35-2.40] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1502243-C | Research Support, Non-U.S. Gov't |
| 11 | 13625439 | rs1502243 | G | A | rs1502243 | 23648065 | 7.18E-05 | Allelic model | 2.07 | [1.42-3.03] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1502243-C | Research Support, Non-U.S. Gov't |
| 11 | 15166201 | rs12226609 | C | T | rs12226609 | 23648065 | 2.74E-05 | Allelic model | 1.75 | [1.34-2.27] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12226609-G | Research Support, Non-U.S. Gov't |
| 11 | 18822037 | rs4627050 | A | G | rs4627050 | 23648065 | 4.00E-06 | Allelic model | 1.93 | [1.45-2.57] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4627050-G | Research Support, Non-U.S. Gov't |
| 11 | 18903604 | rs7946938 | C | T | rs7946938 | 23648065 | 9.86E-05 | Allelic model | 1.84 | [1.36-2.51] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7946938-T | Research Support, Non-U.S. Gov't |
| 11 | 19532506 | rs1055543 | T | C | rs1055543 | 23648065 | 8.47E-05 | Recessive model | 1.5 | [1.06-2.13] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1055543-A | Research Support, Non-U.S. Gov't |
| 11 | 19668438 | rs714585 | A | G | rs714585 | 23648065 | 5.52E-05 | Dominant model | 11.31 | [2.55-50.15] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs714585-A | Research Support, Non-U.S. Gov't |
| 11 | 22717120 | rs1628924 | T | C | rs1628924 | 23648065 | 2.25E-05 | Dominant model | 1.34 | [1.11-1.61] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1628924-T | Research Support, Non-U.S. Gov't |
| 11 | 22729464 | rs337454 | A | G | rs337454 | 23648065 | 2.81E-05 | Dominant model | 1.35 | [1.13-1.63] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs337454-T | Research Support, Non-U.S. Gov't |
| 11 | 22730694 | rs440991 | A | G | rs440991 | 23648065 | 2.82E-05 | Dominant model | 1.35 | [1.13-1.63] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs440991-T | Research Support, Non-U.S. Gov't |
| 11 | 23581968 | rs11027318 | G | A | rs11027318 | 23648065 | 7.05E-05 | Recessive model | 1.49 | [1.06-2.10] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11027318-T | Research Support, Non-U.S. Gov't |
| 11 | 28581430 | rs1596300 | T | C | rs1596300 | 23648065 | 9.37E-05 | Dominant model | 1.9 | [1.33-2.71] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1596300-G | Research Support, Non-U.S. Gov't |
| 11 | 35074000 | rs737503 | C | T | rs737503 | 23648065 | 5.59E-05 | Allelic model | 3.55 | [1.76-7.13] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs737503-G | Research Support, Non-U.S. Gov't |
| 11 | 36134670 | rs4756281 | T | C | rs4756281 | 23648065 | 3.07E-05 | Allelic model | 1.74 | [1.35-2.24] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4756281-C | Research Support, Non-U.S. Gov't |
| 11 | 36202307 | rs4755440 | G | A | rs4755440 | 23648065 | 9.52E-05 | Dominant model | 3.78 | [1.78-8.03] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4755440-A | Research Support, Non-U.S. Gov't |
| 11 | 36215938 | rs12574525 | G | T | rs12574525 | 23648065 | 4.85E-05 | Dominant model | 4.54 | [1.93-10.69] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12574525-C | Research Support, Non-U.S. Gov't |
| 11 | 36221890 | rs11601619 | C | T | rs11601619 | 23648065 | 2.81E-05 | Dominant model | 4.7 | [2.00-11.05] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11601619-C | Research Support, Non-U.S. Gov't |
| 11 | 36233751 | rs1374376 | G | A | rs1374376 | 23648065 | 1.36E-05 | Dominant model | 4.56 | [2.06-10.10] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1374376-G | Research Support, Non-U.S. Gov't |
| 11 | 36235024 | rs12420852 | C | T | rs12420852 | 23648065 | 4.86E-05 | Dominant model | 4.62 | [1.97-10.87] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12420852-G | Research Support, Non-U.S. Gov't |
| 11 | 40320791 | rs16934689 | A | G | rs16934689 | 23648065 | 3.58E-05 | Dominant model | 2.85 | [1.73-4.69] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16934689-C | Research Support, Non-U.S. Gov't |
| 11 | 40904848 | rs11036136 | A | G | rs11036136 | 23648065 | 7.81E-05 | Dominant model | 3.65 | [1.73-7.71] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11036136-A | Research Support, Non-U.S. Gov't |
| 11 | 43105620 | rs9645617 | G | A | rs9645617 | 23648065 | 9.84E-05 | Dominant model | 4.48 | [1.88-10.68] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9645617-C | Research Support, Non-U.S. Gov't |
| 11 | 44784540 | rs7104896 | G | A | rs7104896 | 23648065 | 4.44E-05 | Recessive model | 1.21 | [0.82-1.79] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7104896-C | Research Support, Non-U.S. Gov't |
| 11 | 69078912 | rs10896464 | T | C | rs10896464 | 23648065 | 5.69E-05 | Dominant model | 1.72 | [1.31-2.27] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10896464-A | Research Support, Non-U.S. Gov't |
| 11 | 69256899 | rs4980627 | G | A | rs4980627 | 23648065 | 9.03E-05 | Recessive model | 1.47 | [1.15-1.89] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4980627-G | Research Support, Non-U.S. Gov't |
| 11 | 79941934 | rs1628460 | G | T | rs1628460 | 23648065 | 1.62E-05 | Dominant model | 1.7 | [1.26-2.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1628460-G | Research Support, Non-U.S. Gov't |
| 11 | 80790181 | rs1916054 | G | A | rs1916054 | 23648065 | 9.84E-05 | Allelic model | 1.44 | [1.20-1.73] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1916054-G | Research Support, Non-U.S. Gov't |
| 11 | 83503404 | rs7479949 | T | C | rs7479949 | 23648065 | 3.40E-05 | Dominant model | 2.19 | [1.42-3.37] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7479949-G | Research Support, Non-U.S. Gov't |
| 11 | 83512154 | rs10898155 | C | T | rs10898155 | 23648065 | 6.31E-05 | Dominant model | 2.06 | [1.34-3.18] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10898155-T | Research Support, Non-U.S. Gov't |
| 11 | 84298844 | rs7119459 | T | C | rs7119459 | 23648065 | 9.77E-05 | Allelic model | 2.49 | [1.53-4.04] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7119459-T | Research Support, Non-U.S. Gov't |
| 11 | 86376739 | rs507211 | G | A | rs507211 | 23648065 | 2.35E-05 | Allelic model | 2.79 | [1.74-4.47] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs507211-G | Research Support, Non-U.S. Gov't |
| 11 | 86383994 | rs682915 | T | C | rs682915 | 23648065 | 1.57E-05 | Allelic model | 2.81 | [1.75-4.50] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs682915-T | Research Support, Non-U.S. Gov't |
| 11 | 86386784 | rs594361 | A | G | rs594361 | 23648065 | 1.57E-05 | Allelic model | 2.81 | [1.75-4.50] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs594361-T | Research Support, Non-U.S. Gov't |
| 11 | 86389000 | rs1938936 | C | A | rs1938936 | 23648065 | 1.98E-05 | Allelic model | 2.84 | [1.77-4.57] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1938936-A | Research Support, Non-U.S. Gov't |
| 11 | 86389536 | rs642245 | G | A | rs642245 | 23648065 | 2.10E-05 | Allelic model | 2.81 | [1.75-4.52] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs642245-C | Research Support, Non-U.S. Gov't |
| 11 | 86414027 | rs2512988 | A | G | rs2512988 | 23648065 | 7.58E-06 | Allelic model | 2.94 | [1.83-4.74] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2512988-T | Research Support, Non-U.S. Gov't |
| 11 | 86414282 | rs2512987 | A | G | rs2512987 | 23648065 | 7.00E-06 | Allelic model | 2.99 | [1.86-4.80] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2512987-T | Research Support, Non-U.S. Gov't |
| 11 | 87819271 | rs2220304 | G | A | rs2220304 | 23648065 | 3.65E-05 | Allelic model | 1.69 | [1.31-2.19] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2220304-C | Research Support, Non-U.S. Gov't |
| 11 | 88982718 | rs10741305 | T | C | rs10741305 | 23648065 | 5.32E-05 | Allelic model | 1.69 | [1.31-2.18] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10741305-C | Research Support, Non-U.S. Gov't |
| 11 | 92807679 | rs1703086 | A | G | rs1703086 | pha003095 | 1.71E-05 | phs000221 | phs000501 | 0.01 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1703086-C | NA |
| 11 | 95854094 | rs10765791 | C | T | rs10765791 | 23648065 | 6.60E-05 | Dominant model | 1.47 | [1.15-1.86] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10765791-G | Research Support, Non-U.S. Gov't |
| 11 | 98302817 | rs10790062 | C | T | rs10790062 | 23648065 | 6.28E-05 | Dominant model | 2.73 | [1.56-4.77] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10790062-A | Research Support, Non-U.S. Gov't |
| 11 | 99041999 | rs12789966 | A | G | rs12789966 | 23648065 | 9.74E-05 | Dominant model | 1.33 | [1.12-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12789966-C | Research Support, Non-U.S. Gov't |
| 11 | 99044554 | rs7114546 | C | A | rs7114546 | 23648065 | 9.74E-05 | Dominant model | 1.32 | [1.11-1.57] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7114546-C | Research Support, Non-U.S. Gov't |
| 11 | 103589094 | rs1917445 | C | T | rs1917445 | 21507922 | 6.00E-07 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 11 | 110162430 | rs1676536 | T | C | rs1676536 | 23648065 | 7.72E-05 | Dominant model | 2.06 | [1.40-3.03] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1676536-G | Research Support, Non-U.S. Gov't |
| 11 | 113696653 | rs7111825 | C | T | rs7111825 | 23648065 | 9.01E-05 | Recessive model | 1.29 | [1.08-1.53] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7111825-C | Research Support, Non-U.S. Gov't |
| 11 | 116559002 | rs1145210 | C | T | rs1145210 | 23648065 | 9.42E-05 | Recessive model | 1.33 | [1.07-1.65] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1145210-A | Research Support, Non-U.S. Gov't |
| 11 | 117963766 | rs11216740 | G | A | rs11216740 | 23648065 | 6.93E-05 | Dominant model | 1.86 | [1.22-2.86] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11216740-A | Research Support, Non-U.S. Gov't |
| 11 | 121985367 | rs630852 | A | G | rs630852 | 23648065 | 1.12E-05 | Allelic model | 2 | [1.44-2.79] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs630852-T | Research Support, Non-U.S. Gov't |
| 11 | 128231995 | rs1557477 | T | C | rs1557477 | 23648065 | 5.34E-05 | Recessive model | 1.16 | [0.95-1.42] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1557477-T | Research Support, Non-U.S. Gov't |
| 11 | 134503242 | rs3019643 | A | G | rs3019643 | 23648065 | 3.75E-05 | Allelic model | 1.99 | [1.42-2.78] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3019643-G | Research Support, Non-U.S. Gov't |
| 11 | 134508438 | rs3017963 | A | G | rs3017963 | 23648065 | 2.83E-05 | Allelic model | 2 | [1.43-2.80] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3017963-C | Research Support, Non-U.S. Gov't |
| 11 | 134510309 | rs3018015 | T | C | rs3018015 | 23648065 | 2.83E-05 | Allelic model | 2 | [1.43-2.80] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3018015-G | Research Support, Non-U.S. Gov't |
| 12 | 1416592 | rs16928347 | C | T | rs16928347 | 23648065 | 2.42E-05 | Dominant model | 1.94 | [1.37-2.74] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16928347-A | Research Support, Non-U.S. Gov't |
| 12 | 3556350 | rs6489469 | G | A | rs6489469 | 23648065 | 5.35E-05 | Dominant model | 3.01 | [1.71-5.30] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6489469-T | Research Support, Non-U.S. Gov't |
| 12 | 4325316 | rs7307707 | G | A,C,T | rs7307707 | 23648065 | 1.50E-05 | Dominant model | 1.82 | [1.38-2.41] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7307707-T | Research Support, Non-U.S. Gov't |
| 12 | 5712164 | rs4930766 | T | C | rs4930766 | 23648065 | 7.78E-05 | Allelic model | 2.9 | [1.69-4.97] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4930766-A | Research Support, Non-U.S. Gov't |
| 12 | 6062853 | rs3759320 | C | T | rs3759320 | 23648065 | 5.26E-05 | Dominant model | 3.79 | [1.75-8.18] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3759320-A | Research Support, Non-U.S. Gov't |
| 12 | 6062878 | rs3759321 | G | A | rs3759321 | 23648065 | 9.96E-05 | Dominant model | 3.65 | [1.69-7.91] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3759321-T | Research Support, Non-U.S. Gov't |
| 12 | 6442001 | rs4149639 | T | C | rs4149639 | 23648065 | 3.00E-07 | Allelic model | 4.44 | [2.57-7.68] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4149639-C | Research Support, Non-U.S. Gov't |
| 12 | 6442001 | rs4149639 | T | C | rs4149639 | 23648065 | 7.00E-06 | Allelic model | 2.76 | [1.78-4.29] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4149639-C | Research Support, Non-U.S. Gov't |
| 12 | 6451561 | rs4149621 | T | C | rs4149621 | 23648065 | 6.59E-06 | Allelic model | 3.03 | [1.91-4.81] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4149621-C | Research Support, Non-U.S. Gov't |
| 12 | 6451590 | rs4149570 | A | C | rs4149570 | 23648065 | 6.82E-05 | Allelic model | 1.68 | [1.30-2.17] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4149570-G | Research Support, Non-U.S. Gov't |
| 12 | 14263954 | rs17399790 | C | T | rs17399790 | 23648065 | 4.85E-05 | Dominant model | 1.94 | [1.36-2.77] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17399790-G | Research Support, Non-U.S. Gov't |
| 12 | 14266144 | rs10845883 | T | G | rs10845883 | 23648065 | 3.50E-05 | Allelic model | 4.31 | [2.13-8.76] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10845883-C | Research Support, Non-U.S. Gov't |
| 12 | 14919862 | rs10846059 | T | C | rs10846059 | 23648065 | 6.43E-05 | Allelic model | 7.15 | [2.17-23.57] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10846059-A | Research Support, Non-U.S. Gov't |
| 12 | 23091991 | rs4964061 | C | T | rs4964061 | 23648065 | 9.29E-05 | Recessive model | 1.35 | [1.08-1.69] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4964061-C | Research Support, Non-U.S. Gov't |
| 12 | 25834871 | rs10771232 | A | G | rs10771232 | 23648065 | 1.58E-05 | Dominant model | 1.43 | [1.19-1.73] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10771232-A | Research Support, Non-U.S. Gov't |
| 12 | 31957496 | rs4931558 | T | C | rs4931558 | 23648065 | 6.65E-05 | Recessive model | 1.36 | [1.11-1.66] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4931558-T | Research Support, Non-U.S. Gov't |
| 12 | 32657276 | rs10844223 | G | A | rs10844223 | 23648065 | 6.61E-05 | Allelic model | 2.67 | [1.62-4.40] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10844223-T | Research Support, Non-U.S. Gov't |
| 12 | 39130885 | rs1352122 | G | A | rs1352122 | 23648065 | 9.70E-05 | Dominant model | 2.17 | [1.46-3.23] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1352122-G | Research Support, Non-U.S. Gov't |
| 12 | 40732394 | rs1427271 | T | C | rs1427271 | pha003095 | 9.83E-05 | phs000221 | phs000501 | 0.28 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1427271-T | NA |
| 12 | 45543754 | rs9787988 | A | G | rs9787988 | 23648065 | 6.10E-05 | Recessive model | 1.36 | [1.14-1.63] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9787988-G | Research Support, Non-U.S. Gov't |
| 12 | 45573620 | rs1025090 | T | G | rs1025090 | 23648065 | 8.93E-05 | Recessive model | 1.34 | [1.13-1.60] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1025090-G | Research Support, Non-U.S. Gov't |
| 12 | 54319727 | rs894734 | A | G | rs894734 | 23648065 | 4.00E-06 | Dominant model | 1.62 | [1.28-2.05] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs894734-G | Research Support, Non-U.S. Gov't |
| 12 | 54320805 | rs979013 | C | A | rs979013 | 23648065 | 8.22E-05 | Dominant model | 1.53 | [1.21-1.94] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs979013-A | Research Support, Non-U.S. Gov't |
| 12 | 54324069 | rs2366144 | C | A | rs2366144 | 23648065 | 6.05E-05 | Dominant model | 1.55 | [1.22-1.97] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2366144-A | Research Support, Non-U.S. Gov't |
| 12 | 54737701 | rs2141587 | A | G | rs2141587 | 23648065 | 6.50E-05 | Dominant model | 1.77 | [1.33-2.35] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2141587-T | Research Support, Non-U.S. Gov't |
| 12 | 54737701 | rs2141587 | A | G | rs2141587 | 23648065 | 7.87E-05 | Allelic model | 1.49 | [1.22-1.82] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2141587-T | Research Support, Non-U.S. Gov't |
| 12 | 54748626 | rs4758960 | G | A | rs4758960 | 23648065 | 1.97E-05 | Dominant model | 1.48 | [1.22-1.80] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4758960-C | Research Support, Non-U.S. Gov't |
| 12 | 54748626 | rs4758960 | G | A | rs4758960 | 23648065 | 2.28E-05 | Dominant model | 1.78 | [1.35-2.36] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4758960-C | Research Support, Non-U.S. Gov't |
| 12 | 64209976 | rs10506464 | C | T | rs10506464 | 23648065 | 1.46E-05 | Allelic model | 2.86 | [1.78-4.59] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10506464-G | Research Support, Non-U.S. Gov't |
| 12 | 64210746 | rs12578452 | G | A | rs12578452 | 23648065 | 2.06E-05 | Recessive model | 2.45 | [1.53-3.92] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12578452-G | Research Support, Non-U.S. Gov't |
| 12 | 64213103 | rs4497499 | T | C | rs4497499 | 23648065 | 5.02E-05 | Recessive model | 2.41 | [1.51-3.84] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4497499-A | Research Support, Non-U.S. Gov't |
| 12 | 65280719 | rs1144424 | C | T | rs1144424 | 23648065 | 6.38E-05 | Allelic model | 2.28 | [1.50-3.46] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1144424-G | Research Support, Non-U.S. Gov't |
| 12 | 67245090 | rs905697 | C | T | rs905697 | pha003095 | 2.64E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs905697-T | NA |
| 12 | 67257435 | rs12319870 | G | A | rs12319870 | pha003095 | 6.55E-06 | phs000221 | phs000501 | 0.33 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs12319870-A | NA |
| 12 | 68658270 | rs4913287 | C | T | rs4913287 | 23648065 | 1.84E-05 | Recessive model | 1.5 | [1.07-2.10] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4913287-A | Research Support, Non-U.S. Gov't |
| 12 | 68667462 | rs10506557 | A | C | rs10506557 | 23648065 | 3.34E-05 | Recessive model | 1.66 | [1.18-2.33] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10506557-C | Research Support, Non-U.S. Gov't |
| 12 | 69567211 | rs10878930 | G | A | rs10878930 | 23648065 | 7.73E-05 | Recessive model | 1.61 | [1.17-2.22] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10878930-A | Research Support, Non-U.S. Gov't |
| 12 | 70024023 | rs710745 | T | C | rs710745 | 23648065 | 4.80E-05 | Recessive model | 1.47 | [1.15-1.89] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs710745-C | Research Support, Non-U.S. Gov't |
| 12 | 70067766 | rs710722 | G | A | rs710722 | 23648065 | 7.49E-05 | Recessive model | 1.51 | [1.18-1.93] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs710722-A | Research Support, Non-U.S. Gov't |
| 12 | 70072916 | rs775490 | G | T | rs775490 | 23648065 | 1.78E-05 | Recessive model | 1.6 | [1.25-2.04] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs775490-T | Research Support, Non-U.S. Gov't |
| 12 | 70074492 | rs775484 | A | G | rs775484 | 23648065 | 4.99E-05 | Recessive model | 1.55 | [1.21-1.98] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs775484-G | Research Support, Non-U.S. Gov't |
| 12 | 72903301 | rs954147 | G | A | rs954147 | 23648065 | 2.04E-05 | Dominant model | 1.43 | [1.14-1.80] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs954147-T | Research Support, Non-U.S. Gov't |
| 12 | 72914831 | rs7295506 | C | T | rs7295506 | 23648065 | 7.68E-05 | Dominant model | 1.5 | [1.19-1.88] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7295506-T | Research Support, Non-U.S. Gov't |
| 12 | 74429110 | rs1829127 | G | A | rs1829127 | 23648065 | 4.79E-05 | Dominant model | 1.64 | [1.25-2.16] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1829127-C | Research Support, Non-U.S. Gov't |
| 12 | 75422205 | rs10506678 | G | T | rs10506678 | 23648065 | 6.69E-05 | Recessive model | 1.35 | [1.02-1.78] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10506678-G | Research Support, Non-U.S. Gov't |
| 12 | 81918056 | rs7306960 | C | T | rs7306960 | 23648065 | 9.19E-05 | Dominant model | 2.27 | [1.47-3.50] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7306960-T | Research Support, Non-U.S. Gov't |
| 12 | 84465510 | rs12426820 | T | C | rs12426820 | 23648065 | 3.24E-05 | Dominant model | 2.81 | [1.67-4.73] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12426820-A | Research Support, Non-U.S. Gov't |
| 12 | 84477383 | rs10746307 | A | C | rs10746307 | 23648065 | 4.88E-05 | Allelic model | 2.77 | [1.65-4.67] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10746307-G | Research Support, Non-U.S. Gov't |
| 12 | 90705400 | rs17836993 | G | A | rs17836993 | 23648065 | 3.81E-05 | Dominant model | 3.57 | [1.74-7.31] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17836993-G | Research Support, Non-U.S. Gov't |
| 12 | 95490248 | rs12310399 | T | C | rs12310399 | 23648065 | 2.00E-07 | Recessive model | 1.85 | [1.33-2.58] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12310399-A | Research Support, Non-U.S. Gov't |
| 12 | 95493336 | rs4762311 | T | C | rs4762311 | 23648065 | 2.65E-07 | Recessive model | 1.96 | [1.39-2.76] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4762311-A | Research Support, Non-U.S. Gov't |
| 12 | 95502747 | rs6538592 | G | A | rs6538592 | 23648065 | 5.05E-07 | Recessive model | 1.94 | [1.38-2.74] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6538592-A | Research Support, Non-U.S. Gov't |
| 12 | 103813706 | rs10467022 | C | T | rs10467022 | 23648065 | 3.60E-05 | Dominant model | 2.46 | [1.58-3.81] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10467022-C | Research Support, Non-U.S. Gov't |
| 12 | 103813706 | rs10467022 | C | T | rs10467022 | 23648065 | 5.40E-05 | Dominant model | 1.88 | [1.34-2.65] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10467022-C | Research Support, Non-U.S. Gov't |
| 12 | 103817326 | rs10745966 | C | T | rs10745966 | 23648065 | 1.61E-05 | Dominant model | 1.8 | [1.35-2.41] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10745966-G | Research Support, Non-U.S. Gov't |
| 12 | 103849908 | rs2374076 | A | C | rs2374076 | 23648065 | 3.63E-05 | Dominant model | 1.78 | [1.33-2.38] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2374076-T | Research Support, Non-U.S. Gov't |
| 12 | 103864665 | rs4506750 | A | G | rs4506750 | 23648065 | 1.49E-05 | Dominant model | 1.86 | [1.39-2.48] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4506750-T | Research Support, Non-U.S. Gov't |
| 12 | 103866354 | rs2888731 | T | G | rs2888731 | 23648065 | 1.61E-05 | Dominant model | 1.84 | [1.38-2.46] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2888731-A | Research Support, Non-U.S. Gov't |
| 12 | 110227965 | rs10735104 | C | T | rs10735104 | 23648065 | 2.06E-05 | Allelic model | 4.44 | [2.22-8.90] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10735104-A | Research Support, Non-U.S. Gov't |
| 12 | 113238728 | rs1156817 | A | G | rs1156817 | pha003095 | 9.98E-05 | phs000221 | phs000501 | 0.38 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1156817-G | NA |
| 12 | 122630909 | rs1043763 | G | A | rs1043763 | 23648065 | 7.00E-06 | Dominant model | 1.5 | [1.25-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1043763-T | Research Support, Non-U.S. Gov't |
| 12 | 124894184 | rs12582168 | T | C | rs12582168 | 23648065 | 9.00E-06 | Dominant model | 1.45 | [1.21-1.75] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12582168-C | Research Support, Non-U.S. Gov't |
| 12 | 126944404 | rs4765391 | T | C | rs4765391 | 23648065 | 7.17E-05 | Dominant model | 4.91 | [2.18-11.06] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4765391-A | Research Support, Non-U.S. Gov't |
| 12 | 127846842 | rs1684227 | T | G | rs1684227 | 23648065 | 6.22E-05 | Recessive model | 1.28 | [1.08-1.52] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1684227-G | Research Support, Non-U.S. Gov't |
| 12 | 128762741 | rs12302898 | G | A | rs12302898 | 23648065 | 4.75E-05 | Allelic model | 5.55 | [2.09-14.74] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12302898-A | Research Support, Non-U.S. Gov't |
| 12 | 128916550 | rs10773542 | G | T | rs10773542 | 23648065 | 5.62E-05 | Allelic model | 2.14 | [1.48-3.08] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10773542-A | Research Support, Non-U.S. Gov't |
| 12 | 130770170 | rs7960284 | C | T | rs7960284 | 23648065 | 4.58E-05 | Recessive model | 1.99 | [1.23-3.21] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7960284-C | Research Support, Non-U.S. Gov't |
| 12 | 130893588 | rs7304899 | A | G | rs7304899 | 23648065 | 8.85E-05 | Dominant model | 1.8 | [1.31-2.46] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7304899-A | Research Support, Non-U.S. Gov't |
| 13 | 21043086 | rs4573790 | G | A | rs4573790 | 23648065 | 6.76E-05 | Dominant model | 5.86 | [2.23-15.43] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4573790-T | Research Support, Non-U.S. Gov't |
| 13 | 21047858 | rs9506494 | C | T | rs9506494 | 23648065 | 7.17E-05 | Dominant model | 1.3 | [1.08-1.56] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9506494-A | Research Support, Non-U.S. Gov't |
| 13 | 21048924 | rs9552195 | G | A | rs9552195 | 23648065 | 4.41E-05 | Dominant model | 1.31 | [1.09-1.58] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9552195-T | Research Support, Non-U.S. Gov't |
| 13 | 21050575 | rs7989332 | A | C | rs7989332 | 23648065 | 5.00E-06 | Allelic model | 2.06 | [1.51-2.81] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7989332-G | Research Support, Non-U.S. Gov't |
| 13 | 21057250 | rs9552196 | C | T | rs9552196 | 23648065 | 6.12E-05 | Dominant model | 1.3 | [1.07-1.57] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9552196-C | Research Support, Non-U.S. Gov't |
| 13 | 22753687 | rs9510015 | T | C | rs9510015 | 23648065 | 9.29E-06 | Dominant model | 1.33 | [1.12-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9510015-C | Research Support, Non-U.S. Gov't |
| 13 | 22754093 | rs9580312 | A | G | rs9580312 | 23648065 | 8.00E-06 | Dominant model | 1.33 | [1.12-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9580312-G | Research Support, Non-U.S. Gov't |
| 13 | 22762222 | rs9510029 | A | G | rs9510029 | 23648065 | 6.47E-05 | Dominant model | 1.34 | [1.13-1.59] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9510029-G | Research Support, Non-U.S. Gov't |
| 13 | 22770518 | rs10781825 | A | C | rs10781825 | 23648065 | 2.33E-05 | Dominant model | 1.33 | [1.12-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10781825-G | Research Support, Non-U.S. Gov't |
| 13 | 24525604 | rs2147995 | A | C | rs2147995 | 23648065 | 3.63E-05 | Recessive model | 1.25 | [1.03-1.53] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2147995-C | Research Support, Non-U.S. Gov't |
| 13 | 24525604 | rs35747503 | A | AG | rs2147995 | 23648065 | 3.63E-05 | Recessive model | 1.25 | [1.03-1.53] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2147995-C | Research Support, Non-U.S. Gov't |
| 13 | 24878466 | rs3803218 | A | G | rs3803218 | 23648065 | 2.11E-05 | Allelic model | 2.25 | [1.54-3.29] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3803218-C | Research Support, Non-U.S. Gov't |
| 13 | 25331027 | rs3803217 | A | C | rs3803217 | 23648065 | 8.52E-05 | Dominant model | 2.61 | [1.53-4.46] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3803217-C | Research Support, Non-U.S. Gov't |
| 13 | 28360487 | rs1923834 | C | T | rs1923834 | 23648065 | 5.00E-06 | Dominant model | 3.24 | [1.82-5.74] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1923834-G | Research Support, Non-U.S. Gov't |
| 13 | 30448063 | rs9551757 | C | T | rs9551757 | pha003095 | 1.65E-05 | phs000221 | phs000501 | 0.42 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9551757-T | NA |
| 13 | 30453522 | rs17631397 | A | G | rs17631397 | pha003095 | 2.67E-05 | phs000221 | phs000501 | 0.42 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17631397-G | NA |
| 13 | 31031884 | rs1360485 | C | T | rs1360485 | pha003095 | 1.16E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1360485-C | NA |
| 13 | 33561520 | rs527337 | G | A | rs527337 | 23648065 | 3.20E-05 | Recessive model | 1.52 | [1.19-1.94] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs527337-A | Research Support, Non-U.S. Gov't |
| 13 | 39786449 | rs9532354 | G | A | rs9532354 | 23648065 | 9.93E-05 | Dominant model | 1.77 | [1.25-2.49] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9532354-C | Research Support, Non-U.S. Gov't |
| 13 | 46288145 | rs7317245 | A | G | rs7317245 | 23648065 | 7.89E-05 | Allelic model | 1.59 | NA | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7317245-T | Research Support, Non-U.S. Gov't |
| 13 | 46290082 | rs9316155 | T | C | rs9316155 | 23648065 | 1.51E-05 | Allelic model | 1.66 | [1.32-2.08] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9316155-A | Research Support, Non-U.S. Gov't |
| 13 | 46291526 | rs9534199 | T | C | rs9534199 | 23648065 | 1.69E-05 | Allelic model | 1.67 | [1.33-2.10] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9534199-A | Research Support, Non-U.S. Gov't |
| 13 | 46750002 | rs2209090 | A | G | rs2209090 | 23648065 | 2.67E-05 | Recessive model | 1.76 | [1.19-2.58] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2209090-G | Research Support, Non-U.S. Gov't |
| 13 | 51701547 | rs1340544 | T | C | rs1340544 | 23648065 | 1.78E-05 | Allelic model | 2.14 | [1.52-3.02] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1340544-C | Research Support, Non-U.S. Gov't |
| 13 | 51709017 | rs9563028 | C | A | rs9563028 | 23648065 | 1.66E-05 | Recessive model | 1.99 | [1.41-2.79] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9563028-A | Research Support, Non-U.S. Gov't |
| 13 | 51709017 | rs9563028 | C | A | rs9563028 | 23648065 | 8.13E-05 | Recessive model | 2.14 | [1.39-3.29] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9563028-A | Research Support, Non-U.S. Gov't |
| 13 | 59477851 | rs9597893 | T | C | rs9597893 | 23648065 | 7.87E-05 | Recessive model | 2.12 | [1.15-3.91] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9597893-T | Research Support, Non-U.S. Gov't |
| 13 | 60250843 | rs1350361 | G | A | rs1350361 | 23648065 | 5.14E-05 | Dominant model | 2.4 | [1.52-3.77] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1350361-G | Research Support, Non-U.S. Gov't |
| 13 | 60273298 | rs7336489 | C | T | rs7336489 | 23648065 | 4.82E-05 | Dominant model | 2.42 | [1.53-3.83] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7336489-G | Research Support, Non-U.S. Gov't |
| 13 | 60818288 | rs9570280 | C | A | rs9570280 | 23648065 | 5.58E-05 | Allelic model | 2.22 | [1.50-3.28] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9570280-C | Research Support, Non-U.S. Gov't |
| 13 | 61729112 | rs7994213 | T | C | rs7994213 | 23648065 | 4.47E-05 | Recessive model | 1.37 | [1.04-1.80] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7994213-G | Research Support, Non-U.S. Gov't |
| 13 | 61738208 | rs993877 | C | T | rs993877 | 23648065 | 3.54E-05 | Recessive model | 1.3 | [0.99-1.69] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs993877-A | Research Support, Non-U.S. Gov't |
| 13 | 61867517 | rs9539095 | C | T | rs9539095 | 23648065 | 1.82E-05 | Recessive model | 1.53 | [1.13-2.06] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9539095-A | Research Support, Non-U.S. Gov't |
| 13 | 67267982 | rs7322694 | A | G | rs7322694 | 23648065 | 7.49E-05 | Dominant model | 2.46 | [1.48-4.09] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7322694-A | Research Support, Non-U.S. Gov't |
| 13 | 67379709 | rs956277 | C | T | rs956277 | 23648065 | 4.46E-05 | Dominant model | 1.79 | [1.33-2.40] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs956277-C | Research Support, Non-U.S. Gov't |
| 13 | 71983341 | rs1999603 | A | G | rs1999603 | 23648065 | 1.47E-05 | Recessive model | 1.37 | [1.00-1.86] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1999603-G | Research Support, Non-U.S. Gov't |
| 13 | 71999805 | rs8000025 | A | C | rs8000025 | 23648065 | 2.38E-05 | Recessive model | 1.37 | [1.01-1.87] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8000025-G | Research Support, Non-U.S. Gov't |
| 13 | 72031460 | rs9529897 | C | T | rs9529897 | 23648065 | 1.49E-05 | Recessive model | 1.47 | [1.07-2.01] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9529897-T | Research Support, Non-U.S. Gov't |
| 13 | 77540631 | rs592425 | C | T | rs592425 | 23648065 | 6.93E-05 | Allelic model | 2.11 | [1.47-3.02] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs592425-C | Research Support, Non-U.S. Gov't |
| 13 | 91188066 | rs1929045 | A | G | rs1929045 | pha003095 | 7.72E-05 | phs000221 | phs000501 | 0.28 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1929045-G | NA |
| 13 | 93088651 | rs4771859 | T | C | rs4771859 | 23648065 | 1.00E-06 | Recessive model | 1.33 | [1.09-1.62] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4771859-G | Research Support, Non-U.S. Gov't |
| 13 | 94861913 | rs7984149 | T | C | rs7984149 | 23648065 | 7.39E-05 | Allelic model | 2.14 | [1.48-3.10] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7984149-C | Research Support, Non-U.S. Gov't |
| 13 | 95853870 | rs1751027 | A | G | rs1751027 | 23648065 | 9.40E-05 | Allelic model | 1.63 | [1.29-2.06] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1751027-C | Research Support, Non-U.S. Gov't |
| 13 | 96128857 | rs7984974 | G | A | rs7984974 | 23648065 | 3.74E-05 | Dominant model | 1.64 | [1.28-2.10] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7984974-C | Research Support, Non-U.S. Gov't |
| 13 | 96129510 | rs946232 | A | G | rs946232 | 23648065 | 3.74E-05 | Dominant model | 1.64 | [1.28-2.10] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs946232-T | Research Support, Non-U.S. Gov't |
| 13 | 96852913 | rs4771929 | G | A | rs4771929 | 23648065 | 9.95E-05 | Dominant model | 2 | [1.32-3.02] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4771929-C | Research Support, Non-U.S. Gov't |
| 13 | 96965955 | rs7331682 | T | C | rs7331682 | 23648065 | 6.88E-05 | Dominant model | 1.83 | [1.30-2.56] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7331682-G | Research Support, Non-U.S. Gov't |
| 13 | 106596719 | rs488248 | C | T | rs488248 | 23648065 | 3.00E-06 | Allelic model | 2.9 | [1.80-4.67] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs488248-T | Research Support, Non-U.S. Gov't |
| 13 | 106614005 | rs7317081 | G | T | rs7317081 | 23648065 | 9.21E-06 | Allelic model | 2.82 | [1.74-4.58] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7317081-A | Research Support, Non-U.S. Gov't |
| 13 | 106862224 | rs7338679 | G | A | rs7338679 | 23648065 | 2.54E-05 | Allelic model | 1.85 | [1.38-2.48] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7338679-C | Research Support, Non-U.S. Gov't |
| 13 | 108129963 | rs1323679 | T | C | rs1323679 | 23648065 | 9.84E-05 | Allelic model | 2.07 | [1.45-2.96] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1323679-G | Research Support, Non-U.S. Gov't |
| 13 | 108151476 | rs1555637 | C | A | rs1555637 | 23648065 | 7.18E-05 | Allelic model | 2.04 | [1.44-2.90] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1555637-A | Research Support, Non-U.S. Gov't |
| 13 | 110653926 | rs9559702 | T | C | rs9559702 | 23648065 | 7.79E-05 | Allelic model | 2.14 | [1.47-3.11] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9559702-G | Research Support, Non-U.S. Gov't |
| 13 | 111049623 | rs9515203 | T | C | rs9515203 | 23648065 | 1.78E-05 | Dominant model | 1.95 | [1.43-2.67] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9515203-C | Research Support, Non-U.S. Gov't |
| 13 | 112606210 | rs9577173 | C | T | rs9577173 | pha003095 | 3.42E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9577173-T | NA |
| 13 | 112624185 | rs523042 | T | C | rs523042 | pha003095 | 1.39E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs523042-C | NA |
| 13 | 112628831 | rs11164131 | G | T | rs11164131 | pha003095 | 1.19E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11164131-T | NA |
| 13 | 112865110 | rs928195 | T | C | rs928195 | 23648065 | 5.49E-05 | Recessive model | 1.59 | [1.24-2.03] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs928195-G | Research Support, Non-U.S. Gov't |
| 13 | 112870029 | rs7321489 | A | G | rs7321489 | 23648065 | 9.89E-05 | Dominant model | 1.57 | [1.22-2.02] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7321489-G | Research Support, Non-U.S. Gov't |
| 14 | 21770681 | rs17792599 | A | G | rs17792599 | 23648065 | 8.45E-05 | Dominant model | 19.45 | [2.47-153.09] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17792599-T | Research Support, Non-U.S. Gov't |
| 14 | 22586392 | rs2331494 | C | T | rs2331494 | pha003095 | 4.02E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2331494-T | NA |
| 14 | 22886319 | rs3811236 | C | A,G,T | rs3811236 | 23648065 | 9.63E-05 | Allelic model | 2 | [1.41-2.85] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3811236-A | Research Support, Non-U.S. Gov't |
| 14 | 22915816 | rs12147516 | G | T | rs12147516 | 23648065 | 7.05E-05 | Recessive model | 1.4 | [1.19-1.66] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12147516-A | Research Support, Non-U.S. Gov't |
| 14 | 22937656 | rs12589282 | A | C | rs12589282 | 23648065 | 4.00E-06 | Recessive model | 1.48 | [1.25-1.75] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12589282-G | Research Support, Non-U.S. Gov't |
| 14 | 23311480 | rs17243048 | G | A | rs17243048 | 23648065 | 7.27E-05 | Recessive model | 1.63 | [1.16-2.28] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17243048-A | Research Support, Non-U.S. Gov't |
| 14 | 26654291 | rs4349058 | C | T | rs4349058 | 23648065 | 5.23E-05 | Recessive model | 1.29 | [1.06-1.56] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4349058-T | Research Support, Non-U.S. Gov't |
| 14 | 27508742 | rs1998462 | A | C | rs1998462 | pha003095 | 1.96E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1998462-A | NA |
| 14 | 27510849 | rs9323896 | C | T | rs9323896 | pha003095 | 4.21E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9323896-T | NA |
| 14 | 27510897 | rs9323897 | G | A | rs9323897 | pha003095 | 6.05E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs9323897-A | NA |
| 14 | 27520111 | rs11850868 | T | G | rs11850868 | pha003095 | 8.48E-06 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs11850868-T | NA |
| 14 | 27528240 | rs1951755 | T | G | rs1951755 | pha003095 | 6.96E-05 | phs000221 | phs000501 | 0.2 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1951755-T | NA |
| 14 | 29198059 | rs968045 | G | A | rs968045 | 23648065 | 9.63E-05 | Recessive model | 1.66 | [1.19-2.32] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs968045-T | Research Support, Non-U.S. Gov't |
| 14 | 29243242 | rs17114266 | G | T | rs17114266 | 23648065 | 3.50E-05 | Recessive model | 1.28 | [1.07-1.52] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17114266-A | Research Support, Non-U.S. Gov't |
| 14 | 30003238 | rs1191545 | G | T | rs1191545 | 23648065 | 9.47E-05 | Dominant model | 1.78 | [1.32-2.41] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1191545-A | Research Support, Non-U.S. Gov't |
| 14 | 33011647 | rs1998242 | G | A | rs1998242 | 23648065 | 7.09E-05 | Allelic model | 1.69 | [1.31-2.19] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1998242-A | Research Support, Non-U.S. Gov't |
| 14 | 36402546 | rs1168978 | T | C | rs1168978 | 23648065 | 8.11E-05 | Dominant model | 1.3 | [1.10-1.55] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1168978-C | Research Support, Non-U.S. Gov't |
| 14 | 41194262 | rs11157160 | G | A | rs11157160 | 23648065 | 3.29E-05 | Recessive model | 1.84 | [1.27-2.67] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11157160-G | Research Support, Non-U.S. Gov't |
| 14 | 42547320 | rs4451874 | A | G | rs4451874 | 23648065 | 8.20E-05 | Recessive model | 1.41 | [1.10-1.81] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4451874-G | Research Support, Non-U.S. Gov't |
| 14 | 44623260 | rs10147827 | A | G | rs10147827 | 23648065 | 7.37E-05 | Allelic model | 14.26 | [3.08-66.11] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10147827-C | Research Support, Non-U.S. Gov't |
| 14 | 56231800 | rs7494275 | A | C | rs7494275 | 23648065 | 9.00E-06 | Recessive model | 1.73 | [1.23-2.43] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7494275-C | Research Support, Non-U.S. Gov't |
| 14 | 56238629 | rs10150228 | T | G | rs10150228 | 23648065 | 5.40E-05 | Allelic model | 2.44 | [1.58-3.78] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10150228-C | Research Support, Non-U.S. Gov't |
| 14 | 62611803 | rs12147829 | C | T | rs12147829 | pha003095 | 8.16E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs12147829-T | NA |
| 14 | 67949074 | rs17249111 | A | G | rs17249111 | 23648065 | 9.26E-05 | Dominant model | 2.54 | [1.57-4.13] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17249111-G | Research Support, Non-U.S. Gov't |
| 14 | 69984560 | rs2756966 | G | A | rs2756966 | 23648065 | 6.24E-05 | Recessive model | 1.37 | [0.97-1.94] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2756966-G | Research Support, Non-U.S. Gov't |
| 14 | 71649124 | rs11623881 | C | T | rs11623881 | 23648065 | 1.17E-05 | Recessive model | 1.47 | [1.07-2.00] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11623881-C | Research Support, Non-U.S. Gov't |
| 14 | 75795136 | rs12895755 | C | T | rs12895755 | 23648065 | 7.43E-05 | Recessive model | 1.49 | [1.22-1.83] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12895755-A | Research Support, Non-U.S. Gov't |
| 14 | 84438074 | rs1015277 | A | C | rs1015277 | 23648065 | 3.63E-05 | Dominant model | 2.1 | [1.46-3.01] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1015277-C | Research Support, Non-U.S. Gov't |
| 14 | 84463633 | rs7140245 | T | G | rs7140245 | 23648065 | 2.57E-05 | Dominant model | 2.13 | [1.51-3.02] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7140245-C | Research Support, Non-U.S. Gov't |
| 14 | 84485390 | rs17119456 | A | G | rs17119456 | 23648065 | 7.57E-05 | Dominant model | 1.96 | [1.41-2.75] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17119456-C | Research Support, Non-U.S. Gov't |
| 14 | 84509670 | rs17119553 | A | G | rs17119553 | 23648065 | 4.02E-05 | Dominant model | 1.79 | [1.36-2.36] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17119553-G | Research Support, Non-U.S. Gov't |
| 14 | 86850928 | rs804930 | C | T | rs804930 | 23648065 | 1.09E-05 | Dominant model | 1.5 | [1.24-1.82] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs804930-C | Research Support, Non-U.S. Gov't |
| 14 | 86898200 | rs10484102 | G | A | rs10484102 | 23648065 | 1.11E-05 | Allelic model | 1.62 | [1.30-2.02] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10484102-G | Research Support, Non-U.S. Gov't |
| 14 | 86902054 | rs12882718 | C | T | rs12882718 | 23648065 | 6.00E-06 | Dominant model | 1.56 | [1.28-1.88] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12882718-T | Research Support, Non-U.S. Gov't |
| 14 | 86923368 | rs10132264 | T | C | rs10132264 | 23648065 | 4.28E-05 | Allelic model | 1.56 | [1.26-1.94] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10132264-A | Research Support, Non-U.S. Gov't |
| 14 | 87672957 | rs1484981 | C | A | rs1484981 | 23648065 | 9.67E-05 | Recessive model | 1.17 | [0.81-1.69] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1484981-T | Research Support, Non-U.S. Gov't |
| 14 | 87740087 | rs17123224 | C | T | rs17123224 | 23648065 | 4.32E-05 | Recessive model | 1.26 | [0.87-1.83] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17123224-A | Research Support, Non-U.S. Gov't |
| 14 | 87741025 | rs1756650 | C | T | rs1756650 | 23648065 | 2.00E-06 | Recessive model | 1.39 | [0.95-2.01] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1756650-G | Research Support, Non-U.S. Gov't |
| 14 | 87752261 | rs7142552 | A | G | rs7142552 | 23648065 | 3.18E-05 | Recessive model | 1.44 | [1.07-1.94] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7142552-C | Research Support, Non-U.S. Gov't |
| 14 | 87770671 | rs1365524 | T | G | rs1365524 | 23648065 | 6.54E-05 | Recessive model | 1.61 | [1.20-2.15] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1365524-C | Research Support, Non-U.S. Gov't |
| 14 | 87795892 | rs1430561 | G | A | rs1430561 | 23648065 | 8.02E-05 | Recessive model | 1.6 | [1.19-2.14] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1430561-A | Research Support, Non-U.S. Gov't |
| 14 | 88355122 | rs10133218 | G | T | rs10133218 | 23648065 | 6.16E-05 | Dominant model | 1.38 | [1.16-1.65] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10133218-T | Research Support, Non-U.S. Gov't |
| 14 | 90031107 | rs243183 | G | A | rs243183 | 23648065 | 3.41E-05 | Allelic model | 1.68 | [1.32-2.15] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs243183-T | Research Support, Non-U.S. Gov't |
| 14 | 92534915 | rs8004149 | C | T | rs8004149 | 23648065 | 9.63E-05 | Recessive model | 1.31 | [1.10-1.57] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8004149-G | Research Support, Non-U.S. Gov't |
| 14 | 92548785 | rs1048755 | C | T | rs1048755 | 23648065 | 7.45E-05 | Recessive model | 1.31 | [1.10-1.56] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1048755-C | Research Support, Non-U.S. Gov't |
| 14 | 92559862 | rs1997919 | C | T | rs1997919 | 23648065 | 7.38E-05 | Recessive model | 1.31 | [1.10-1.56] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1997919-C | Research Support, Non-U.S. Gov't |
| 14 | 94422192 | rs12882974 | C | T | rs12882974 | 23648065 | 4.88E-05 | Allelic model | 1.7 | [1.32-2.19] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12882974-T | Research Support, Non-U.S. Gov't |
| 14 | 94422346 | rs730959 | A | G | rs730959 | 23648065 | 7.93E-05 | Allelic model | 1.7 | [1.31-2.21] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs730959-T | Research Support, Non-U.S. Gov't |
| 14 | 96206070 | rs2369304 | G | A | rs2369304 | 21507922 | 9.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 14 | 97345806 | rs4905558 | G | A | rs4905558 | 21507922 | 8.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 14 | 97983221 | rs1001504 | C | A | rs1001504 | 23648065 | 3.99E-05 | Recessive model | 1.27 | [1.04-1.53] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1001504-G | Research Support, Non-U.S. Gov't |
| 14 | 97987857 | rs8022296 | G | A | rs8022296 | 23648065 | 7.00E-06 | Recessive model | 1.27 | [1.06-1.52] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8022296-G | Research Support, Non-U.S. Gov't |
| 14 | 98000813 | rs17095542 | G | A | rs17095542 | 23648065 | 3.75E-05 | Recessive model | 1.25 | [1.03-1.50] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17095542-C | Research Support, Non-U.S. Gov't |
| 14 | 99387545 | rs200331 | A | G | rs200331 | pha003095 | 4.33E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs200331-A | NA |
| 14 | 99390803 | rs200324 | T | G | rs200324 | pha003095 | 3.42E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs200324-T | NA |
| 14 | 99782579 | rs8018158 | C | T | rs8018158 | 23648065 | 8.33E-05 | Recessive model | 1.57 | [1.11-2.21] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8018158-G | Research Support, Non-U.S. Gov't |
| 15 | 26990651 | rs8038471 | G | A | rs8038471 | 23648065 | 7.57E-05 | Allelic model | 1.99 | [1.42-2.79] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8038471-G | Research Support, Non-U.S. Gov't |
| 15 | 31463378 | rs7169523 | G | A | rs7169523 | 23648065 | 7.99E-05 | Recessive model | 1.39 | [0.97-1.98] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7169523-A | Research Support, Non-U.S. Gov't |
| 15 | 35537031 | rs318339 | G | T | rs318339 | 23648065 | 6.97E-05 | Allelic model | 1.75 | [1.32-2.33] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs318339-G | Research Support, Non-U.S. Gov't |
| 15 | 35548468 | rs2622756 | A | G | rs2622756 | 23648065 | 6.86E-05 | Allelic model | 1.76 | [1.33-2.34] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2622756-A | Research Support, Non-U.S. Gov't |
| 15 | 38739298 | rs12905733 | T | G | rs12905733 | 23648065 | 7.40E-05 | Dominant model | 1.57 | [1.21-2.04] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12905733-G | Research Support, Non-U.S. Gov't |
| 15 | 38779626 | rs12591633 | A | G | rs12591633 | 23648065 | 7.05E-05 | Dominant model | 1.59 | [1.22-2.08] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12591633-G | Research Support, Non-U.S. Gov't |
| 15 | 38783682 | rs7181389 | G | A | rs7181389 | 23648065 | 7.40E-05 | Dominant model | 1.61 | [1.23-2.09] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7181389-T | Research Support, Non-U.S. Gov't |
| 15 | 38791826 | rs4334257 | A | C | rs4334257 | 23648065 | 7.70E-05 | Dominant model | 1.59 | [1.22-2.08] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4334257-G | Research Support, Non-U.S. Gov't |
| 15 | 40728036 | rs12368 | C | T | rs12368 | 23648065 | 5.82E-05 | Recessive model | 1.42 | [1.02-1.97] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12368-T | Research Support, Non-U.S. Gov't |
| 15 | 41249871 | rs3887640 | T | G | rs3887640 | 23648065 | 3.69E-05 | Dominant model | 2.29 | [1.50-3.47] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3887640-T | Research Support, Non-U.S. Gov't |
| 15 | 42233077 | rs17687882 | C | T | rs17687882 | pha003095 | 5.28E-05 | phs000221 | phs000501 | 0.3 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs17687882-T | NA |
| 15 | 46640863 | rs1564781 | T | C | rs1564781 | 23648065 | 5.18E-05 | Allelic model | 2.25 | [1.52-3.31] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1564781-T | Research Support, Non-U.S. Gov't |
| 15 | 51471700 | rs12441919 | A | C | rs12441919 | 23648065 | 9.97E-05 | Allelic model | 1.62 | [1.27-2.06] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12441919-C | Research Support, Non-U.S. Gov't |
| 15 | 53702840 | rs12911817 | T | G | rs12911817 | 23648065 | 4.41E-05 | Dominant model | 1.52 | [1.18-1.95] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12911817-G | Research Support, Non-U.S. Gov't |
| 15 | 53709744 | rs4776147 | T | C | rs4776147 | 23648065 | 4.20E-05 | Dominant model | 1.52 | [1.19-1.95] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4776147-C | Research Support, Non-U.S. Gov't |
| 15 | 53758922 | rs671948 | A | C | rs671948 | 23648065 | 4.37E-05 | Allelic model | 1.69 | [1.31-2.18] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs671948-G | Research Support, Non-U.S. Gov't |
| 15 | 55456510 | rs16976033 | A | G | rs16976033 | 21507922 | 7.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 15 | 55946732 | rs9920546 | C | T | rs9920546 | 23648065 | 5.06E-06 | Dominant model | 3.69 | [2.01-6.78] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9920546-T | Research Support, Non-U.S. Gov't |
| 15 | 55950082 | rs11071200 | C | A | rs11071200 | 23648065 | 9.00E-07 | Dominant model | 8.24 | [2.89-23.52] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11071200-T | Research Support, Non-U.S. Gov't |
| 15 | 56000063 | rs2414424 | C | T | rs2414424 | 23648065 | 4.30E-05 | Allelic model | 1.8 | [1.36-2.39] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2414424-A | Research Support, Non-U.S. Gov't |
| 15 | 58733512 | rs166362 | G | A | rs166362 | 23648065 | 7.74E-05 | Recessive model | 1.62 | [1.26-2.09] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs166362-G | Research Support, Non-U.S. Gov't |
| 15 | 60001060 | rs11071474 | T | C | rs11071474 | 23648065 | 4.29E-05 | Recessive model | 1.47 | [1.03-2.10] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11071474-T | Research Support, Non-U.S. Gov't |
| 15 | 61223718 | rs1482050 | A | C | rs1482050 | 23648065 | 9.76E-05 | Allelic model | 1.59 | [1.26-2.00] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1482050-T | Research Support, Non-U.S. Gov't |
| 15 | 62764680 | rs370873 | C | T | rs370873 | 23648065 | 4.25E-05 | Recessive model | 2.42 | [1.52-3.87] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs370873-C | Research Support, Non-U.S. Gov't |
| 15 | 63161831 | rs625901 | A | G | rs625901 | 23648065 | 6.53E-05 | Allelic model | 2.9 | [1.72-4.89] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs625901-G | Research Support, Non-U.S. Gov't |
| 15 | 63566702 | rs1017546 | A | C | rs1017546 | 23648065 | 2.48E-05 | Recessive model | 1.57 | [1.19-2.07] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1017546-G | Research Support, Non-U.S. Gov't |
| 15 | 63569017 | rs3784672 | G | T | rs3784672 | 23648065 | 8.39E-05 | Recessive model | 1.52 | [1.08-2.15] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3784672-T | Research Support, Non-U.S. Gov't |
| 15 | 63569184 | rs3784671 | C | A | rs3784671 | 23648065 | 1.47E-05 | Recessive model | 1.59 | [1.21-2.10] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3784671-A | Research Support, Non-U.S. Gov't |
| 15 | 67241653 | rs266300 | T | C | rs266300 | 23648065 | 6.25E-05 | Allelic model | 1.67 | [1.30-2.15] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs266300-T | Research Support, Non-U.S. Gov't |
| 15 | 71449398 | rs5024066 | A | G | rs5024066 | 23648065 | 7.43E-05 | Allelic model | 1.64 | [1.29-2.09] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs5024066-T | Research Support, Non-U.S. Gov't |
| 15 | 71904835 | rs11858418 | A | G | rs11858418 | 23648065 | 2.43E-05 | Recessive model | 1.41 | [1.05-1.89] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11858418-T | Research Support, Non-U.S. Gov't |
| 15 | 71904835 | rs11858418 | A | G | rs11858418 | 23648065 | 6.47E-05 | Recessive model | 1.16 | [0.97-1.38] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11858418-T | Research Support, Non-U.S. Gov't |
| 15 | 71905049 | rs13329645 | G | A | rs13329645 | 23648065 | 2.43E-05 | Recessive model | 1.41 | [1.05-1.89] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13329645-C | Research Support, Non-U.S. Gov't |
| 15 | 71905049 | rs13329645 | G | A | rs13329645 | 23648065 | 6.47E-05 | Recessive model | 1.16 | [0.97-1.38] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13329645-C | Research Support, Non-U.S. Gov't |
| 15 | 74770334 | rs8027459 | G | A | rs8027459 | 23648065 | 9.26E-05 | Allelic model | 3.38 | [1.87-6.12] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8027459-A | Research Support, Non-U.S. Gov't |
| 15 | 75128501 | rs9210 | T | C | rs9210 | 23648065 | 1.18E-05 | Dominant model | 1.7 | [1.30-2.22] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9210-G | Research Support, Non-U.S. Gov't |
| 15 | 75131661 | rs4886615 | A | G | rs4886615 | 23648065 | 1.76E-05 | Dominant model | 1.68 | [1.29-2.20] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4886615-G | Research Support, Non-U.S. Gov't |
| 15 | 75132319 | rs936229 | A | G | rs936229 | 23648065 | 4.00E-06 | Dominant model | 1.69 | [1.30-2.18] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs936229-G | Research Support, Non-U.S. Gov't |
| 15 | 75140854 | rs3765066 | G | A | rs3765066 | 23648065 | 4.98E-05 | Recessive model | 1.28 | [1.08-1.52] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3765066-T | Research Support, Non-U.S. Gov't |
| 15 | 75140854 | rs3765066 | G | A | rs3765066 | 23648065 | 8.90E-05 | Recessive model | 1.32 | [1.03-1.69] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3765066-T | Research Support, Non-U.S. Gov't |
| 15 | 75159433 | rs11072511 | A | G | rs11072511 | 23648065 | 8.80E-05 | Recessive model | 1.41 | [0.98-2.03] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11072511-C | Research Support, Non-U.S. Gov't |
| 15 | 75189930 | rs1130741 | A | G | rs1130741 | 23648065 | 8.66E-05 | Recessive model | 1.4 | [0.97-2.02] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1130741-G | Research Support, Non-U.S. Gov't |
| 15 | 75196176 | rs4886636 | G | A | rs4886636 | 23648065 | 8.66E-05 | Recessive model | 1.4 | [0.97-2.02] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4886636-T | Research Support, Non-U.S. Gov't |
| 15 | 75255322 | rs6495132 | C | T | rs6495132 | 23648065 | 6.28E-05 | Allelic model | 1.42 | [1.19-1.68] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6495132-C | Research Support, Non-U.S. Gov't |
| 15 | 75344451 | rs4886651 | C | T | rs4886651 | 23648065 | 5.66E-05 | Allelic model | 3.31 | [1.86-5.90] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4886651-G | Research Support, Non-U.S. Gov't |
| 15 | 75385622 | rs7162941 | C | T | rs7162941 | 23648065 | 2.08E-05 | Allelic model | 1.45 | [1.22-1.71] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7162941-G | Research Support, Non-U.S. Gov't |
| 15 | 75449674 | rs4886670 | G | T | rs4886670 | 23648065 | 1.00E-06 | Allelic model | 1.61 | [1.33-1.94] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4886670-A | Research Support, Non-U.S. Gov't |
| 15 | 75449674 | rs4886670 | G | T | rs4886670 | 23648065 | 7.00E-06 | Allelic model | 1.84 | [1.41-2.38] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4886670-A | Research Support, Non-U.S. Gov't |
| 15 | 75472094 | rs16966785 | A | G | rs16966785 | 23648065 | 8.78E-05 | Dominant model | 1.37 | [1.14-1.64] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16966785-A | Research Support, Non-U.S. Gov't |
| 15 | 78164706 | rs11857176 | T | C | rs11857176 | 23648065 | 8.00E-07 | Recessive model | 1.8 | [1.13-2.87] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11857176-A | Research Support, Non-U.S. Gov't |
| 15 | 83387752 | rs7182320 | G | A | rs7182320 | 23648065 | 9.24E-05 | Recessive model | 1.94 | [1.17-3.25] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7182320-A | Research Support, Non-U.S. Gov't |
| 15 | 85405369 | rs306198 | A | G | rs306198 | 23648065 | 6.83E-05 | Recessive model | 2.06 | [1.26-3.35] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs306198-C | Research Support, Non-U.S. Gov't |
| 15 | 85415386 | rs12900463 | T | C | rs12900463 | 23648065 | 4.00E-06 | Recessive model | 2.15 | [1.34-3.46] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12900463-C | Research Support, Non-U.S. Gov't |
| 15 | 85415799 | rs4842994 | C | T | rs4842994 | 23648065 | 4.03E-06 | Recessive model | 2.15 | [1.34-3.46] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4842994-A | Research Support, Non-U.S. Gov't |
| 15 | 86068022 | rs12910789 | C | T | rs12910789 | 23648065 | 7.46E-05 | Recessive model | 1.47 | [1.10-1.95] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12910789-G | Research Support, Non-U.S. Gov't |
| 15 | 88756201 | rs4887212 | T | C | rs4887212 | 23648065 | 8.17E-05 | Dominant model | 1.52 | [1.09-2.13] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4887212-T | Research Support, Non-U.S. Gov't |
| 15 | 89238255 | rs6496520 | A | C | rs6496520 | 23648065 | 4.72E-05 | Recessive model | 1.29 | [1.08-1.54] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6496520-T | Research Support, Non-U.S. Gov't |
| 15 | 94179432 | rs4777936 | T | C | rs4777936 | 23648065 | 8.80E-05 | Dominant model | 1.53 | [1.10-2.11] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4777936-C | Research Support, Non-U.S. Gov't |
| 15 | 94371122 | rs7172139 | C | T | rs7172139 | 23648065 | 8.38E-05 | Recessive model | 1.35 | [1.12-1.64] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7172139-C | Research Support, Non-U.S. Gov't |
| 15 | 94669167 | rs7174567 | G | A | rs7174567 | 23648065 | 2.75E-05 | Recessive model | 2.44 | [1.29-4.59] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7174567-T | Research Support, Non-U.S. Gov't |
| 15 | 96809782 | rs1437588 | A | G | rs1437588 | 23648065 | 4.77E-05 | Dominant model | 1.94 | [1.39-2.70] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1437588-T | Research Support, Non-U.S. Gov't |
| 15 | 96809782 | rs1437588 | A | G | rs1437588 | 23648065 | 7.82E-05 | Dominant model | 1.51 | [1.19-1.92] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1437588-T | Research Support, Non-U.S. Gov't |
| 15 | 101972931 | rs8024621 | G | A | rs8024621 | 23648065 | 1.22E-05 | Dominant model | 1.8 | [1.35-2.40] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8024621-T | Research Support, Non-U.S. Gov't |
| 16 | 3550147 | rs11077346 | C | A | rs11077346 | 23648065 | 8.75E-05 | Dominant model | 1.39 | [1.09-1.77] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11077346-C | Research Support, Non-U.S. Gov't |
| 16 | 5409673 | rs1358489 | C | T | rs1358489 | 23648065 | 1.46E-05 | Allelic model | 2.14 | [1.51-3.03] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1358489-A | Research Support, Non-U.S. Gov't |
| 16 | 8044973 | rs9933906 | C | T | rs9933906 | 23648065 | 7.83E-05 | Recessive model | 1.81 | [1.12-2.92] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9933906-G | Research Support, Non-U.S. Gov't |
| 16 | 10769958 | rs2719710 | T | C | rs2719710 | pha003095 | 9.52E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2719710-C | NA |
| 16 | 13043431 | rs7189560 | T | C | rs7189560 | 23648065 | 4.89E-05 | Dominant model | 2.28 | [1.46-3.54] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7189560-C | Research Support, Non-U.S. Gov't |
| 16 | 13046720 | rs924546 | A | G | rs924546 | 23648065 | 7.91E-05 | Dominant model | 2.23 | [1.44-3.45] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs924546-C | Research Support, Non-U.S. Gov't |
| 16 | 13467705 | rs2051738 | T | C | rs2051738 | 23648065 | 6.76E-05 | Dominant model | 2.42 | [1.33-4.39] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2051738-C | Research Support, Non-U.S. Gov't |
| 16 | 17271327 | rs752482 | T | C | rs752482 | 23648065 | 3.39E-05 | Allelic model | 1.8 | [1.37-2.36] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs752482-G | Research Support, Non-U.S. Gov't |
| 16 | 22885421 | rs2238486 | G | A | rs2238486 | 23648065 | 1.09E-05 | Dominant model | 1.63 | [1.25-2.12] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2238486-T | Research Support, Non-U.S. Gov't |
| 16 | 22889186 | rs2519974 | G | A | rs2519974 | 23648065 | 4.00E-06 | Dominant model | 1.65 | [1.26-2.15] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2519974-T | Research Support, Non-U.S. Gov't |
| 16 | 22891084 | rs916670 | C | T | rs916670 | 23648065 | 9.96E-05 | Recessive model | 1.48 | [1.15-1.91] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs916670-G | Research Support, Non-U.S. Gov't |
| 16 | 24456837 | rs8054383 | A | G | rs8054383 | pha003095 | 5.47E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs8054383-G | NA |
| 16 | 24486366 | rs271011 | C | T | rs271011 | pha003095 | 1.83E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs271011-T | NA |
| 16 | 24488497 | rs271015 | C | T | rs271015 | pha003095 | 3.49E-07 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs271015-T | NA |
| 16 | 25011619 | rs8061484 | C | T | rs8061484 | 23648065 | 8.92E-05 | Allelic model | 1.63 | [1.28-2.08] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8061484-G | Research Support, Non-U.S. Gov't |
| 16 | 30500761 | rs3087438 | G | A | rs3087438 | 23648065 | 2.77E-05 | Recessive model | 1.3 | [1.08-1.55] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3087438-G | Research Support, Non-U.S. Gov't |
| 16 | 46644903 | rs35313904 | G | A | rs35313904 | 23648065 | 3.40E-05 | Dominant model | 1.97 | [1.28-3.03] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs35313904-G | Research Support, Non-U.S. Gov't |
| 16 | 48602733 | rs12443883 | C | T | rs12443883 | 23648065 | 3.90E-05 | Dominant model | 1.61 | [1.24-2.08] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12443883-A | Research Support, Non-U.S. Gov't |
| 16 | 51658435 | rs2647967 | C | T | rs2647967 | 23648065 | 8.44E-05 | Recessive model | 1.24 | [1.01-1.51] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2647967-G | Research Support, Non-U.S. Gov't |
| 16 | 51666146 | rs2647969 | T | G | rs2647969 | 23648065 | 9.36E-05 | Recessive model | 1.22 | [1.00-1.48] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2647969-A | Research Support, Non-U.S. Gov't |
| 16 | 51666246 | rs2647970 | A | G | rs2647970 | 23648065 | 9.44E-05 | Recessive model | 1.22 | [1.00-1.49] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2647970-A | Research Support, Non-U.S. Gov't |
| 16 | 54514123 | rs12929998 | A | C | rs12929998 | 23648065 | 2.77E-05 | Dominant model | 2.1 | [1.44-3.06] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12929998-C | Research Support, Non-U.S. Gov't |
| 16 | 54527296 | rs12051408 | T | C | rs12051408 | 23648065 | 8.16E-05 | Dominant model | 1.41 | [1.13-1.74] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12051408-T | Research Support, Non-U.S. Gov't |
| 16 | 54733746 | rs1420562 | T | C | rs1420562 | 23648065 | 8.27E-05 | Recessive model | 1.33 | [1.12-1.58] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1420562-T | Research Support, Non-U.S. Gov't |
| 16 | 54851741 | rs4410070 | A | C | rs4410070 | 23648065 | 7.11E-05 | Dominant model | 1.35 | [1.13-1.60] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4410070-C | Research Support, Non-U.S. Gov't |
| 16 | 56812300 | rs13329802 | C | T | rs13329802 | 23648065 | 6.34E-05 | Allelic model | 1.6 | [1.27-2.01] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13329802-A | Research Support, Non-U.S. Gov't |
| 16 | 60577200 | rs1530795 | T | C | rs1530795 | 23648065 | 6.37E-05 | Recessive model | 1.35 | [1.06-1.72] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1530795-T | Research Support, Non-U.S. Gov't |
| 16 | 62131626 | rs9938191 | T | C | rs9938191 | 23648065 | 1.40E-05 | Allelic model | 2.33 | [1.61-3.37] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9938191-C | Research Support, Non-U.S. Gov't |
| 16 | 62137472 | rs9924310 | G | A | rs9924310 | 23648065 | 5.16E-05 | Allelic model | 2.22 | [1.53-3.23] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9924310-T | Research Support, Non-U.S. Gov't |
| 16 | 74861095 | rs6564173 | A | G | rs6564173 | 23648065 | 5.41E-05 | Recessive model | 1.6 | [1.25-2.05] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6564173-C | Research Support, Non-U.S. Gov't |
| 16 | 77310808 | rs7201773 | A | G | rs7201773 | 23648065 | 7.87E-05 | Recessive model | 2.31 | [1.22-4.36] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7201773-C | Research Support, Non-U.S. Gov't |
| 16 | 77319899 | rs12934894 | A | G | rs12934894 | 23648065 | 8.33E-05 | Recessive model | 1.46 | [1.19-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12934894-G | Research Support, Non-U.S. Gov't |
| 16 | 77322254 | rs17712956 | A | G | rs17712956 | 23648065 | 3.14E-05 | Recessive model | 1.45 | [1.18-1.79] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17712956-C | Research Support, Non-U.S. Gov't |
| 16 | 77328895 | rs12935229 | C | T | rs12935229 | 23648065 | 4.00E-06 | Recessive model | 1.5 | [1.21-1.84] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12935229-A | Research Support, Non-U.S. Gov't |
| 16 | 77328990 | rs12935394 | C | A | rs12935394 | 23648065 | 4.40E-06 | Recessive model | 1.5 | [1.21-1.84] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12935394-T | Research Support, Non-U.S. Gov't |
| 16 | 78872859 | rs11649397 | G | A | rs11649397 | 23648065 | 4.02E-05 | Dominant model | 2.11 | [1.46-3.05] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11649397-A | Research Support, Non-U.S. Gov't |
| 16 | 79063156 | rs2550698 | T | G | rs2550698 | 23648065 | 4.10E-05 | Allelic model | 3.46 | [1.80-6.66] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2550698-A | Research Support, Non-U.S. Gov't |
| 16 | 79067690 | rs2656641 | C | T | rs2656641 | 23648065 | 3.02E-05 | Allelic model | 3.68 | [1.86-7.27] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2656641-G | Research Support, Non-U.S. Gov't |
| 16 | 80032104 | rs11645885 | C | A | rs11645885 | 23648065 | 6.33E-05 | Recessive model | 1.85 | [1.18-2.89] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11645885-G | Research Support, Non-U.S. Gov't |
| 16 | 80050661 | rs11642717 | A | G | rs11642717 | 23648065 | 5.63E-05 | Allelic model | 2.47 | [1.59-3.84] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11642717-T | Research Support, Non-U.S. Gov't |
| 16 | 80568573 | rs4577099 | C | T | rs4577099 | 23648065 | 3.50E-05 | Allelic model | 1.94 | [1.42-2.65] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4577099-A | Research Support, Non-U.S. Gov't |
| 16 | 81774798 | rs12446319 | T | C | rs12446319 | 23648065 | 9.00E-06 | Allelic model | 2.03 | [1.48-2.77] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12446319-A | Research Support, Non-U.S. Gov't |
| 16 | 81984437 | rs4888197 | A | G | rs4888197 | 23648065 | 1.32E-05 | Allelic model | 2.45 | [1.66-3.62] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4888197-G | Research Support, Non-U.S. Gov't |
| 16 | 83412113 | rs1013465 | T | G | rs1013465 | 23648065 | 6.50E-05 | Dominant model | 1.46 | [1.18-1.80] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1013465-C | Research Support, Non-U.S. Gov't |
| 16 | 83417673 | rs12050931 | A | C | rs12050931 | 23648065 | 2.76E-05 | Recessive model | 1.34 | [1.13-1.60] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12050931-C | Research Support, Non-U.S. Gov't |
| 16 | 83626088 | rs16960938 | G | A | rs16960938 | 23648065 | 3.60E-05 | Recessive model | 1.61 | [1.19-2.17] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16960938-T | Research Support, Non-U.S. Gov't |
| 16 | 83662293 | rs16961072 | C | T | rs16961072 | 23648065 | 6.94E-05 | Allelic model | 1.84 | [1.37-2.49] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16961072-G | Research Support, Non-U.S. Gov't |
| 16 | 84304674 | rs244844 | T | C | rs244844 | pha003095 | 1.30E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs244844-C | NA |
| 16 | 84654935 | rs2925055 | A | G | rs2925055 | 23648065 | 1.69E-05 | Allelic model | 1.45 | [1.23-1.72] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2925055-C | Research Support, Non-U.S. Gov't |
| 16 | 86093721 | rs4843897 | A | G | rs4843897 | 23648065 | 1.99E-05 | Dominant model | 1.41 | [1.19-1.67] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4843897-T | Research Support, Non-U.S. Gov't |
| 16 | 89703424 | rs445537 | A | G | rs445537 | 23648065 | 9.77E-05 | Allelic model | 2.56 | [1.61-4.08] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs445537-C | Research Support, Non-U.S. Gov't |
| 17 | 1866892 | rs4525525 | G | T | rs4525525 | 23648065 | 4.64E-05 | Allelic model | 1.69 | [1.32-2.16] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4525525-T | Research Support, Non-U.S. Gov't |
| 17 | 2589022 | rs7216704 | C | T | rs7216704 | 23648065 | 9.29E-05 | Dominant model | 1.94 | NA | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7216704-T | Research Support, Non-U.S. Gov't |
| 17 | 3313127 | rs11656466 | C | T | rs11656466 | 23648065 | 3.63E-05 | Dominant model | 1.57 | [1.21-2.02] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11656466-C | Research Support, Non-U.S. Gov't |
| 17 | 3342002 | rs9303174 | A | C | rs9303174 | 23648065 | 7.50E-05 | Dominant model | 1.57 | [1.20-2.05] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9303174-T | Research Support, Non-U.S. Gov't |
| 17 | 4955206 | rs8072032 | G | T | rs8072032 | 23648065 | 8.31E-05 | Dominant model | 3.51 | [1.82-6.76] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8072032-G | Research Support, Non-U.S. Gov't |
| 17 | 4989326 | rs4790741 | A | G | rs4790741 | 23648065 | 3.34E-05 | Allelic model | 4.58 | [2.24-9.35] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4790741-G | Research Support, Non-U.S. Gov't |
| 17 | 5770670 | rs7218232 | C | T | rs7218232 | 23648065 | 5.03E-05 | Recessive model | 1.69 | [1.22-2.35] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7218232-G | Research Support, Non-U.S. Gov't |
| 17 | 9808571 | rs2286531 | T | G | rs2286531 | 23648065 | 9.67E-05 | Recessive model | 1.51 | [1.16-1.97] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2286531-A | Research Support, Non-U.S. Gov't |
| 17 | 9874145 | rs3826529 | G | A | rs3826529 | 23648065 | 8.01E-06 | Recessive model | 1.55 | [1.22-1.97] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3826529-A | Research Support, Non-U.S. Gov't |
| 17 | 9875205 | rs3786094 | T | C | rs3786094 | 23648065 | 6.00E-06 | Recessive model | 1.53 | [1.21-1.94] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3786094-C | Research Support, Non-U.S. Gov't |
| 17 | 10681423 | rs8080671 | A | G | rs8080671 | 23648065 | 7.90E-05 | Recessive model | 1.45 | NA | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8080671-G | Research Support, Non-U.S. Gov't |
| 17 | 12777402 | rs11651483 | A | G | rs11651483 | 23648065 | 3.00E-07 | Recessive model | 1.36 | [1.12-1.64] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11651483-C | Research Support, Non-U.S. Gov't |
| 17 | 16315919 | rs7217735 | A | G | rs7217735 | 23648065 | 3.05E-05 | Allelic model | 2.08 | [1.47-2.93] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7217735-T | Research Support, Non-U.S. Gov't |
| 17 | 16318932 | rs3813769 | T | C | rs3813769 | 23648065 | 3.53E-05 | Allelic model | 2.09 | [1.47-2.96] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3813769-T | Research Support, Non-U.S. Gov't |
| 17 | 30206059 | rs11658318 | T | C | rs11658318 | 23648065 | 1.94E-05 | Recessive model | 2.25 | [1.52-3.32] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11658318-T | Research Support, Non-U.S. Gov't |
| 17 | 30809455 | rs4523973 | G | A | rs4523973 | 23648065 | 5.32E-05 | Allelic model | 2.61 | [1.58-4.30] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4523973-C | Research Support, Non-U.S. Gov't |
| 17 | 30812845 | rs756785 | T | C | rs756785 | 23648065 | 5.41E-05 | Allelic model | 2.63 | [1.60-4.34] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs756785-T | Research Support, Non-U.S. Gov't |
| 17 | 30820176 | rs2285428 | T | C | rs2285428 | 23648065 | 5.41E-05 | Allelic model | 2.63 | [1.60-4.34] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2285428-T | Research Support, Non-U.S. Gov't |
| 17 | 31938138 | rs12943567 | T | C | rs12943567 | 23648065 | 5.62E-05 | Dominant model | 3.51 | [1.82-6.78] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12943567-T | Research Support, Non-U.S. Gov't |
| 17 | 32797925 | rs1367955 | G | T | rs1367955 | pha003095 | 5.19E-07 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1367955-G | NA |
| 17 | 32810443 | rs891754 | A | C | rs891754 | pha003095 | 7.35E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs891754-C | NA |
| 17 | 36034423 | rs3110647 | A | G | rs3110647 | 23648065 | 6.44E-05 | Allelic model | 1.65 | [1.29-2.11] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3110647-G | Research Support, Non-U.S. Gov't |
| 17 | 38156712 | rs4794822 | C | T | rs4794822 | 20172861 | 6.00E-10 | NA | 0.1 | [0.07-0.13] unit decrease | 5,771 Japanese individuals | Japanese(5771) | ALL(5771) | ASN(5771) | ALL(5771) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4794822-C |
| 17 | 39444101 | rs12451126 | C | T | rs12451126 | 23648065 | 8.95E-05 | Dominant model | 1.38 | [1.15-1.66] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12451126-T | Research Support, Non-U.S. Gov't |
| 17 | 39453510 | rs12449502 | C | T | rs12449502 | 23648065 | 9.05E-05 | Dominant model | 1.38 | [1.15-1.65] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12449502-A | Research Support, Non-U.S. Gov't |
| 17 | 43733264 | rs1706719 | C | T | rs1706719 | 23648065 | 8.57E-05 | Allelic model | 1.98 | [1.43-2.75] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1706719-G | Research Support, Non-U.S. Gov't |
| 17 | 44868187 | rs12452064 | G | A | rs12452064 | 23648065 | 9.10E-05 | Allelic model | 2 | [1.42-2.82] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12452064-C | Research Support, Non-U.S. Gov't |
| 17 | 45406167 | rs11867160 | A | G | rs11867160 | 23648065 | 9.25E-05 | Allelic model | 3.5 | [1.86-6.56] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11867160-A | Research Support, Non-U.S. Gov't |
| 17 | 45490251 | rs3883318 | C | T | rs3883318 | 23648065 | 9.25E-05 | Allelic model | 3.5 | [1.86-6.56] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3883318-G | Research Support, Non-U.S. Gov't |
| 17 | 47591609 | rs734194 | T | G | rs734194 | pha003095 | 6.28E-05 | phs000221 | phs000501 | 0.32 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs734194-G | NA |
| 17 | 48718531 | rs4148409 | T | C,G | rs4148409 | 23648065 | 4.27E-05 | Allelic model | 2.57 | [1.61-4.11] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4148409-C | Research Support, Non-U.S. Gov't |
| 17 | 49853021 | rs2319453 | T | C | rs2319453 | 23648065 | 4.18E-05 | Recessive model | 1.46 | [1.14-1.87] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2319453-A | Research Support, Non-U.S. Gov't |
| 17 | 54262845 | rs9911043 | G | A | rs9911043 | 23648065 | 7.90E-05 | Allelic model | 4 | [1.99-8.03] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9911043-C | Research Support, Non-U.S. Gov't |
| 17 | 54813751 | rs227665 | A | C | rs227665 | 23648065 | 3.24E-05 | Recessive model | 1.48 | [1.17-1.87] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs227665-G | Research Support, Non-U.S. Gov't |
| 17 | 58907917 | rs9899338 | T | G | rs9899338 | 23648065 | 4.68E-05 | Dominant model | 2.38 | [1.51-3.73] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9899338-T | Research Support, Non-U.S. Gov't |
| 17 | 58921974 | rs4456565 | T | C | rs4456565 | 23648065 | 4.92E-05 | Dominant model | 2.35 | [1.50-3.69] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4456565-T | Research Support, Non-U.S. Gov't |
| 17 | 58998658 | rs6504006 | C | T | rs6504006 | 23648065 | 5.14E-05 | Dominant model | 2.34 | [1.49-3.67] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6504006-C | Research Support, Non-U.S. Gov't |
| 17 | 59003189 | rs7213603 | T | C | rs7213603 | 23648065 | 9.79E-05 | Dominant model | 2.19 | [1.45-3.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7213603-T | Research Support, Non-U.S. Gov't |
| 17 | 59017025 | rs8080784 | T | C | rs8080784 | 23648065 | 9.79E-05 | Dominant model | 2.19 | [1.45-3.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8080784-A | Research Support, Non-U.S. Gov't |
| 17 | 59022395 | rs9914370 | A | G | rs9914370 | 23648065 | 9.79E-05 | Dominant model | 2.19 | [1.45-3.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9914370-A | Research Support, Non-U.S. Gov't |
| 17 | 59087808 | rs9652858 | G | A | rs9652858 | 23648065 | 6.44E-05 | Dominant model | 2.21 | [1.47-3.33] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9652858-G | Research Support, Non-U.S. Gov't |
| 17 | 61616959 | rs4968656 | A | G | rs4968656 | 23648065 | 4.07E-05 | Recessive model | 1.31 | [1.10-1.57] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4968656-G | Research Support, Non-U.S. Gov't |
| 17 | 61619379 | rs12949197 | C | T | rs12949197 | 23648065 | 4.07E-05 | Recessive model | 1.32 | [1.10-1.58] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12949197-T | Research Support, Non-U.S. Gov't |
| 17 | 62259376 | rs9896542 | A | G | rs9896542 | 23648065 | 8.09E-05 | Dominant model | 2.26 | [1.44-3.56] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9896542-A | Research Support, Non-U.S. Gov't |
| 17 | 62266253 | rs4968701 | C | T | rs4968701 | 23648065 | 2.03E-05 | Dominant model | 2.47 | [1.57-3.88] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4968701-C | Research Support, Non-U.S. Gov't |
| 17 | 62268147 | rs1010940 | A | G | rs1010940 | 23648065 | 4.93E-05 | Dominant model | 2.34 | [1.49-3.67] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1010940-T | Research Support, Non-U.S. Gov't |
| 17 | 62268535 | rs11079531 | G | A | rs11079531 | 23648065 | 4.93E-05 | Dominant model | 2.34 | [1.49-3.67] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11079531-G | Research Support, Non-U.S. Gov't |
| 17 | 62317999 | rs9915054 | A | G | rs9915054 | 23648065 | 4.93E-05 | Dominant model | 2.34 | [1.49-3.67] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9915054-T | Research Support, Non-U.S. Gov't |
| 17 | 67215712 | rs12941264 | C | T | rs12941264 | 23648065 | 2.69E-05 | Recessive model | 1.41 | [1.16-1.72] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12941264-C | Research Support, Non-U.S. Gov't |
| 17 | 68666455 | rs2367005 | T | G | rs2367005 | 23648065 | 9.80E-05 | Dominant model | 1.61 | [1.25-2.07] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2367005-A | Research Support, Non-U.S. Gov't |
| 17 | 69980044 | rs2190492 | G | T | rs2190492 | 23648065 | 1.70E-05 | Dominant model | 4.09 | [1.87-8.96] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2190492-T | Research Support, Non-U.S. Gov't |
| 17 | 69986412 | rs10512580 | C | A | rs10512580 | 23648065 | 2.71E-05 | Dominant model | 4.05 | [1.85-8.87] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10512580-A | Research Support, Non-U.S. Gov't |
| 17 | 70091433 | rs9903394 | A | G | rs9903394 | 23648065 | 4.99E-05 | Dominant model | 1.38 | [1.16-1.65] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9903394-T | Research Support, Non-U.S. Gov't |
| 17 | 70721707 | rs8071840 | A | G | rs8071840 | 23648065 | 8.72E-05 | Allelic model | 3.45 | [1.88-6.35] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8071840-G | Research Support, Non-U.S. Gov't |
| 17 | 70735225 | rs9944510 | G | T | rs9944510 | 23648065 | 8.72E-05 | Allelic model | 3.45 | [1.88-6.35] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9944510-A | Research Support, Non-U.S. Gov't |
| 17 | 71600245 | rs790092 | T | C | rs790092 | 23648065 | 8.40E-05 | Allelic model | 5.07 | [2.12-12.15] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs790092-C | Research Support, Non-U.S. Gov't |
| 17 | 72422081 | rs16978038 | T | C | rs16978038 | 23648065 | 8.90E-05 | Allelic model | 2.2 | [1.49-3.25] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16978038-C | Research Support, Non-U.S. Gov't |
| 17 | 72751663 | rs9904111 | C | T | rs9904111 | 23648065 | 5.23E-05 | Allelic model | 2.35 | [1.52-3.65] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9904111-C | Research Support, Non-U.S. Gov't |
| 17 | 72769739 | rs2305213 | A | G | rs2305213 | 23648065 | 6.83E-05 | Allelic model | 2.8 | [1.63-4.80] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2305213-T | Research Support, Non-U.S. Gov't |
| 17 | 72769739 | rs2305213 | A | G | rs2305213 | 23648065 | 8.93E-05 | Allelic model | 2.11 | [1.42-3.13] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2305213-T | Research Support, Non-U.S. Gov't |
| 17 | 75608685 | rs1077759 | C | T | rs1077759 | 23648065 | 4.23E-05 | Dominant model | 2.1 | [1.39-3.18] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1077759-G | Research Support, Non-U.S. Gov't |
| 17 | 76613675 | rs4796808 | G | T | rs4796808 | 23648065 | 9.24E-05 | Recessive model | 1.85 | [1.27-2.70] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4796808-G | Research Support, Non-U.S. Gov't |
| 17 | 77268173 | rs4274472 | G | A | rs4274472 | 23648065 | 6.94E-05 | Recessive model | 1.62 | [1.19-2.22] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4274472-G | Research Support, Non-U.S. Gov't |
| 17 | 77909438 | rs3169601 | T | C | rs3169601 | 23648065 | 7.04E-05 | Recessive model | 1.42 | [0.99-2.02] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3169601-A | Research Support, Non-U.S. Gov't |
| 18 | 954465 | rs1610274 | G | A | rs1610274 | 23648065 | 2.45E-05 | Recessive model | 1.55 | [1.21-1.98] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1610274-C | Research Support, Non-U.S. Gov't |
| 18 | 958056 | rs8090931 | G | A | rs8090931 | 23648065 | 1.09E-05 | Recessive model | 1.58 | [1.24-2.03] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8090931-C | Research Support, Non-U.S. Gov't |
| 18 | 3670649 | rs1675244 | A | G | rs1675244 | 23648065 | 8.96E-05 | Recessive model | 1.7 | [1.11-2.60] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1675244-T | Research Support, Non-U.S. Gov't |
| 18 | 3671652 | rs1116345 | T | C | rs1116345 | 23648065 | 9.68E-05 | Recessive model | 1.68 | [1.10-2.56] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1116345-A | Research Support, Non-U.S. Gov't |
| 18 | 4074007 | rs7240625 | T | G | rs7240625 | 23648065 | 6.22E-05 | Dominant model | 2.65 | [1.59-4.44] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7240625-C | Research Support, Non-U.S. Gov't |
| 18 | 4539085 | rs7228133 | G | T | rs7228133 | 23648065 | 2.00E-06 | Recessive model | 1.26 | [1.03-1.52] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7228133-C | Research Support, Non-U.S. Gov't |
| 18 | 8711942 | rs1249489 | G | A | rs1249489 | 23648065 | 3.67E-05 | Recessive model | 2.07 | [1.41-3.04] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1249489-C | Research Support, Non-U.S. Gov't |
| 18 | 11259831 | rs1566198 | G | T | rs1566198 | 23648065 | 5.80E-05 | Recessive model | 1.42 | [1.11-1.82] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1566198-G | Research Support, Non-U.S. Gov't |
| 18 | 20885221 | rs6507580 | T | C | rs6507580 | pha003095 | 8.53E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6507580-T | NA |
| 18 | 25507049 | rs12709794 | C | T | rs12709794 | 23648065 | 3.02E-05 | Dominant model | 2.33 | [1.38-3.92] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12709794-C | Research Support, Non-U.S. Gov't |
| 18 | 28110019 | rs972697 | G | A | rs972697 | 23648065 | 9.00E-05 | Allelic model | 1.81 | [1.35-2.43] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs972697-C | Research Support, Non-U.S. Gov't |
| 18 | 29407057 | rs639595 | G | A | rs639595 | 23648065 | 8.20E-05 | Recessive model | 1.27 | [1.06-1.51] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs639595-C | Research Support, Non-U.S. Gov't |
| 18 | 29424289 | rs9966530 | A | G | rs9966530 | 23648065 | 6.04E-05 | Recessive model | 1.27 | [1.07-1.52] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9966530-T | Research Support, Non-U.S. Gov't |
| 18 | 29561668 | rs4799615 | C | A | rs4799615 | 23648065 | 9.79E-05 | Recessive model | 1.38 | [1.15-1.64] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4799615-A | Research Support, Non-U.S. Gov't |
| 18 | 36884204 | rs2032268 | T | C | rs2032268 | 23648065 | 8.83E-05 | Allelic model | 1.83 | [1.36-2.48] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2032268-C | Research Support, Non-U.S. Gov't |
| 18 | 36886378 | rs10502722 | T | G | rs10502722 | 23648065 | 6.73E-05 | Allelic model | 1.84 | [1.36-2.49] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10502722-C | Research Support, Non-U.S. Gov't |
| 18 | 46283912 | rs1542593 | G | A | rs1542593 | 23648065 | 6.77E-05 | Allelic model | 2.18 | [1.51-3.15] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1542593-A | Research Support, Non-U.S. Gov't |
| 18 | 48243318 | rs7240429 | T | C | rs7240429 | 23648065 | 1.69E-05 | Allelic model | 2.32 | [1.57-3.43] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7240429-T | Research Support, Non-U.S. Gov't |
| 18 | 50903050 | rs17504372 | C | T | rs17504372 | 23648065 | 5.99E-05 | Allelic model | 3.02 | [1.82-5.03] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17504372-A | Research Support, Non-U.S. Gov't |
| 18 | 53693949 | rs1364417 | C | A | rs1364417 | 23648065 | 5.91E-05 | Recessive model | 2.39 | [1.29-4.43] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1364417-T | Research Support, Non-U.S. Gov't |
| 18 | 56165164 | rs2277720 | G | A | rs2277720 | 23648065 | 4.41E-05 | Allelic model | 1.69 | [1.31-2.19] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2277720-C | Research Support, Non-U.S. Gov't |
| 18 | 58208260 | rs12455135 | C | T | rs12455135 | 23648065 | 5.17E-05 | Dominant model | 1.33 | [1.12-1.57] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12455135-T | Research Support, Non-U.S. Gov't |
| 18 | 58869249 | rs1008632 | C | T | rs1008632 | 23648065 | 8.30E-05 | Recessive model | 1.53 | [1.18-1.98] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1008632-G | Research Support, Non-U.S. Gov't |
| 18 | 61840388 | rs6567416 | T | C | rs6567416 | pha003095 | 5.55E-07 | phs000221 | phs000501 | 0.32 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6567416-C | NA |
| 18 | 62164462 | rs9960678 | T | C | rs9960678 | 23648065 | 2.17E-05 | Recessive model | 1.48 | [1.05-2.08] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9960678-A | Research Support, Non-U.S. Gov't |
| 18 | 62170726 | rs4553720 | T | C | rs4553720 | 23648065 | 7.00E-06 | Recessive model | 1.55 | [1.13-2.12] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4553720-T | Research Support, Non-U.S. Gov't |
| 18 | 67363227 | rs4312402 | T | C | rs4312402 | 23648065 | 1.73E-05 | Recessive model | 1.5 | [1.10-2.05] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4312402-G | Research Support, Non-U.S. Gov't |
| 18 | 74484734 | rs4890871 | G | A | rs4890871 | 23648065 | 6.14E-06 | Dominant model | 1.67 | [1.30-2.14] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4890871-T | Research Support, Non-U.S. Gov't |
| 18 | 74488280 | rs2406342 | G | T | rs2406342 | 23648065 | 2.00E-06 | Dominant model | 1.7 | [1.32-2.18] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2406342-T | Research Support, Non-U.S. Gov't |
| 18 | 75605399 | rs9961113 | T | C | rs9961113 | 23648065 | 1.00E-06 | Allelic model | 2.47 | [1.71-3.58] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9961113-C | Research Support, Non-U.S. Gov't |
| 18 | 76426068 | rs2941853 | C | T | rs2941853 | pha003095 | 6.88E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2941853-T | NA |
| 19 | 5421962 | rs11667049 | A | G | rs11667049 | 23648065 | 9.16E-05 | Dominant model | 1.35 | [1.14-1.60] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11667049-A | Research Support, Non-U.S. Gov't |
| 19 | 5423643 | rs1384936 | C | T | rs1384936 | 23648065 | 1.56E-05 | Allelic model | 1.49 | [1.25-1.78] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1384936-C | Research Support, Non-U.S. Gov't |
| 19 | 5425795 | rs4807760 | T | C | rs4807760 | 23648065 | 4.48E-05 | Allelic model | 1.51 | [1.24-1.84] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4807760-T | Research Support, Non-U.S. Gov't |
| 19 | 6042059 | rs2288846 | C | T | rs2288846 | 23648065 | 9.76E-05 | Allelic model | 1.94 | [1.38-2.72] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2288846-C | Research Support, Non-U.S. Gov't |
| 19 | 6095431 | rs17304450 | G | A | rs17304450 | 23648065 | 8.34E-05 | Allelic model | 1.66 | [1.28-2.15] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs17304450-C | Research Support, Non-U.S. Gov't |
| 19 | 6475613 | rs3745571 | T | C | rs3745571 | 23648065 | 8.00E-06 | Dominant model | 1.73 | [1.28-2.34] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3745571-T | Research Support, Non-U.S. Gov't |
| 19 | 7487313 | rs4804602 | G | A | rs4804602 | 23648065 | 5.12E-05 | Dominant model | 1.46 | [1.14-1.86] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4804602-G | Research Support, Non-U.S. Gov't |
| 19 | 7488671 | rs11260076 | A | G | rs11260076 | 23648065 | 8.67E-05 | Dominant model | 1.47 | [1.15-1.87] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11260076-T | Research Support, Non-U.S. Gov't |
| 19 | 9401159 | rs12975784 | C | T | rs12975784 | pha003095 | 3.52E-05 | phs000221 | phs000501 | 0.41 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs12975784-T | NA |
| 19 | 10596780 | rs9676881 | G | A | rs9676881 | 23648065 | 9.12E-05 | Recessive model | 1.41 | [1.05-1.89] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9676881-T | Research Support, Non-U.S. Gov't |
| 19 | 14574252 | rs4926214 | A | G | rs4926214 | 23648065 | 8.55E-05 | Allelic model | 1.71 | [1.30-2.24] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4926214-A | Research Support, Non-U.S. Gov't |
| 19 | 15133787 | rs10424547 | C | A | rs10424547 | 23648065 | 2.64E-05 | Dominant model | 1.54 | [1.21-1.97] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10424547-C | Research Support, Non-U.S. Gov't |
| 19 | 15133926 | rs8112667 | C | A | rs8112667 | 23648065 | 3.60E-05 | Dominant model | 1.54 | [1.21-1.96] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8112667-C | Research Support, Non-U.S. Gov't |
| 19 | 15133926 | rs8112667 | C | A | rs8112667 | 23648065 | 9.33E-05 | Dominant model | 1.73 | [1.25-2.39] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8112667-C | Research Support, Non-U.S. Gov't |
| 19 | 17546710 | rs7254837 | T | C | rs7254837 | 23648065 | 3.93E-05 | Allelic model | 2.02 | [1.41-2.89] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7254837-G | Research Support, Non-U.S. Gov't |
| 19 | 20054823 | rs6511061 | G | A | rs6511061 | 23648065 | 7.51E-05 | Recessive model | 1.17 | [0.97-1.41] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6511061-T | Research Support, Non-U.S. Gov't |
| 19 | 20108062 | rs8104863 | T | C | rs8104863 | 23648065 | 5.27E-05 | Allelic model | 3.4 | [1.84-6.30] | 83 Japanese ancestry cases; 66 Japanese ancestry controls | Japanese(149) | ALL(149) | ASN(149) | ALL(149) | Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8104863-G | Research Support, Non-U.S. Gov't |
| 19 | 20238148 | rs1725939 | A | C | rs1725939 | 23648065 | 2.00E-05 | Allelic model | 1.71 | [1.33-2.18] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1725939-G | Research Support, Non-U.S. Gov't |
| 19 | 20242274 | rs1618723 | G | A | rs1618723 | 23648065 | 1.52E-05 | Allelic model | 1.72 | [1.34-2.20] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1618723-T | Research Support, Non-U.S. Gov't |
| 19 | 20291263 | rs836896 | T | C | rs836896 | 23648065 | 1.40E-05 | Recessive model | 1.72 | [1.35-2.21] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs836896-G | Research Support, Non-U.S. Gov't |
| 19 | 20329111 | rs1654260 | G | A | rs1654260 | 23648065 | 8.00E-06 | Allelic model | 1.75 | [1.37-2.24] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1654260-A | Research Support, Non-U.S. Gov't |
| 19 | 20329637 | rs1654261 | G | A | rs1654261 | 23648065 | 8.49E-06 | Allelic model | 1.75 | [1.37-2.24] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1654261-T | Research Support, Non-U.S. Gov't |
| 19 | 20411543 | rs7247148 | A | G | rs7247148 | 23648065 | 8.87E-05 | Allelic model | 1.61 | [1.27-2.04] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7247148-C | Research Support, Non-U.S. Gov't |
| 19 | 20466055 | rs7254670 | T | C | rs7254670 | 23648065 | 5.99E-05 | Recessive model | 1.51 | [1.20-1.90] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7254670-C | Research Support, Non-U.S. Gov't |
| 19 | 22438069 | rs283147 | A | C | rs283147 | 23648065 | 4.25E-05 | Recessive model | 1.57 | [1.11-2.21] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs283147-T | Research Support, Non-U.S. Gov't |
| 19 | 23468966 | rs431270 | A | C | rs431270 | 23648065 | 3.17E-05 | Allelic model | 2.86 | [1.76-4.64] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs431270-A | Research Support, Non-U.S. Gov't |
| 19 | 23545250 | rs1044095 | A | G | rs1044095 | 23648065 | 3.17E-05 | Allelic model | 2.86 | [1.76-4.64] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1044095-G | Research Support, Non-U.S. Gov't |
| 19 | 23685823 | rs2640203 | T | C | rs2640203 | 23648065 | 7.01E-05 | Allelic model | 2.81 | [1.71-4.60] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2640203-T | Research Support, Non-U.S. Gov't |
| 19 | 28597809 | rs2867823 | C | A | rs2867823 | 23648065 | 9.94E-05 | Dominant model | 1.98 | [1.36-2.89] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2867823-T | Research Support, Non-U.S. Gov't |
| 19 | 28835571 | rs2159327 | G | A | rs2159327 | 23648065 | 2.66E-06 | Dominant model | 1.87 | [1.35-2.60] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2159327-C | Research Support, Non-U.S. Gov't |
| 19 | 28866596 | rs995834 | G | A | rs995834 | 23648065 | 1.00E-06 | Dominant model | 1.87 | [1.36-2.57] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs995834-C | Research Support, Non-U.S. Gov't |
| 19 | 29757697 | rs2193516 | G | A | rs2193516 | 23648065 | 3.29E-05 | Allelic model | 1.87 | [1.39-2.50] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2193516-C | Research Support, Non-U.S. Gov't |
| 19 | 29761748 | rs888301 | T | C | rs888301 | 23648065 | 6.06E-05 | Allelic model | 1.84 | [1.38-2.47] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs888301-A | Research Support, Non-U.S. Gov't |
| 19 | 29764587 | rs12460869 | T | C | rs12460869 | 23648065 | 3.58E-05 | Recessive model | 1.83 | [1.37-2.46] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs12460869-T | Research Support, Non-U.S. Gov't |
| 19 | 29784673 | rs7408479 | A | G | rs7408479 | 23648065 | 8.69E-05 | Allelic model | 1.83 | [1.36-2.46] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7408479-T | Research Support, Non-U.S. Gov't |
| 19 | 30920536 | rs7247381 | T | C | rs7247381 | 23648065 | 8.60E-05 | Recessive model | 1.5 | [1.22-1.84] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7247381-G | Research Support, Non-U.S. Gov't |
| 19 | 30937843 | rs33428 | A | G | rs33428 | 23648065 | 3.00E-06 | Dominant model | 1.38 | [1.16-1.63] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs33428-G | Research Support, Non-U.S. Gov't |
| 19 | 31651267 | rs750499 | T | C | rs750499 | pha003095 | 3.11E-05 | phs000221 | phs000501 | 0.13 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs750499-T | NA |
| 19 | 31654615 | rs6510186 | T | C | rs6510186 | pha003095 | 3.95E-05 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6510186-T | NA |
| 19 | 37171202 | rs3108207 | T | G | rs3108207 | pha003095 | 2.77E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3108207-G | NA |
| 19 | 37179123 | rs3108558 | A | G | rs3108558 | pha003095 | 4.27E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3108558-G | NA |
| 19 | 37217437 | rs3108581 | T | C | rs3108581 | pha003095 | 3.82E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3108581-C | NA |
| 19 | 49610389 | rs3795055 | T | C | rs3795055 | 23648065 | 4.74E-05 | Dominant model | 1.56 | [1.20-2.03] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs3795055-G | Research Support, Non-U.S. Gov't |
| 19 | 50483541 | rs16981612 | C | T | rs16981612 | 23648065 | 6.03E-05 | Dominant model | 1.72 | [1.29-2.31] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16981612-C | Research Support, Non-U.S. Gov't |
| 19 | 50540471 | rs11883067 | G | A | rs11883067 | 23648065 | 2.68E-05 | Dominant model | 1.76 | [1.31-2.36] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11883067-G | Research Support, Non-U.S. Gov't |
| 19 | 56900486 | rs9636161 | C | T | rs9636161 | 23648065 | 7.12E-05 | Dominant model | 2.65 | [1.60-4.40] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9636161-G | Research Support, Non-U.S. Gov't |
| 19 | 58830261 | rs7359922 | T | C | rs7359922 | 23648065 | 1.27E-05 | Allelic model | 2.96 | [1.82-4.82] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7359922-G | Research Support, Non-U.S. Gov't |
| 20 | 344079 | rs6037430 | T | C | rs6037430 | 23648065 | 9.74E-06 | Allelic model | 3.11 | [1.81-5.36] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6037430-G | Research Support, Non-U.S. Gov't |
| 20 | 934313 | rs6140734 | G | A | rs6140734 | 23648065 | 5.70E-05 | Recessive model | 1.6 | [1.18-2.17] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6140734-T | Research Support, Non-U.S. Gov't |
| 20 | 1175894 | rs6078104 | G | A | rs6078104 | 23648065 | 8.71E-05 | Allelic model | 3.44 | [1.85-6.38] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6078104-T | Research Support, Non-U.S. Gov't |
| 20 | 3630107 | rs2595582 | G | A | rs2595582 | 23648065 | 9.95E-05 | Allelic model | 1.83 | [1.36-2.47] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2595582-T | Research Support, Non-U.S. Gov't |
| 20 | 4731022 | rs6037950 | C | T | rs6037950 | 23648065 | 7.52E-05 | Dominant model | 1.43 | [1.17-1.74] | 428 Japanese ancestry cases; 743 Japanese ancestry controls | Japanese(1171) | ALL(1171) | ASN(1171) | ALL(1171) | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6037950-C | Research Support, Non-U.S. Gov't |
| 20 | 5813582 | rs237084 | C | T | rs237084 | 23648065 | 1.59E-05 | Allelic model | 1.89 | [1.41-2.53] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs237084-G | Research Support, Non-U.S. Gov't |
| 20 | 5821185 | rs237091 | G | A | rs237091 | 23648065 | 1.54E-05 | Allelic model | 1.89 | [1.41-2.54] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs237091-C | Research Support, Non-U.S. Gov't |
| 20 | 7624747 | rs6086143 | A | C | rs6086143 | 23648065 | 2.17E-05 | Recessive model | 1.3 | [0.92-1.83] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6086143-A | Research Support, Non-U.S. Gov't |
| 20 | 7654897 | rs6055249 | A | G | rs6055249 | 23648065 | 2.18E-05 | Recessive model | 1.32 | [0.94-1.86] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6055249-G | Research Support, Non-U.S. Gov't |
| 20 | 7752366 | rs6077251 | C | T | rs6077251 | 23648065 | 3.00E-06 | Allelic model | 2.07 | [1.54-2.77] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6077251-T | Research Support, Non-U.S. Gov't |
| 20 | 7756027 | rs2092380 | G | A | rs2092380 | 23648065 | 3.87E-06 | Dominant model | 2.01 | [1.49-2.70] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2092380-T | Research Support, Non-U.S. Gov't |
| 20 | 7836143 | rs6077278 | C | T | rs6077278 | 23648065 | 6.99E-06 | Allelic model | 2 | [1.49-2.67] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6077278-T | Research Support, Non-U.S. Gov't |
| 20 | 7838533 | rs8116938 | G | A | rs8116938 | 23648065 | 6.99E-06 | Allelic model | 2 | [1.49-2.67] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8116938-T | Research Support, Non-U.S. Gov't |
| 20 | 7847156 | rs16994091 | C | T | rs16994091 | 23648065 | 6.99E-06 | Allelic model | 2 | [1.49-2.67] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16994091-A | Research Support, Non-U.S. Gov't |
| 20 | 8639474 | rs2076639 | C | A | rs2076639 | 23648065 | 5.38E-05 | Dominant model | 2.42 | [1.53-3.83] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2076639-C | Research Support, Non-U.S. Gov't |
| 20 | 9365303 | rs2072910 | T | C | rs2072910 | 20172861 | 3.00E-10 | NA | 0.11 | [0.07-0.15] unit decrease | 5,771 Japanese individuals | Japanese(5771) | ALL(5771) | ASN(5771) | ALL(5771) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2072910-C |
| 20 | 10165933 | rs883382 | A | G | rs883382 | 23648065 | 2.79E-05 | Dominant model | 5.62 | [2.07-15.25] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs883382-T | Research Support, Non-U.S. Gov't |
| 20 | 10183517 | rs6039763 | A | G | rs6039763 | 23648065 | 2.00E-06 | Dominant model | 5.97 | [2.50-14.23] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6039763-A | Research Support, Non-U.S. Gov't |
| 20 | 10197086 | rs1889189 | T | C | rs1889189 | 23648065 | 1.89E-05 | Dominant model | 5.51 | [2.18-13.93] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1889189-A | Research Support, Non-U.S. Gov't |
| 20 | 10198954 | rs6039769 | A | C | rs6039769 | 23648065 | 4.98E-05 | Dominant model | 6.17 | [2.06-18.46] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6039769-T | Research Support, Non-U.S. Gov't |
| 20 | 10975841 | rs6108793 | T | C | rs6108793 | 23648065 | 8.42E-05 | Allelic model | 1.53 | [1.24-1.88] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6108793-C | Research Support, Non-U.S. Gov't |
| 20 | 13134768 | rs6078938 | T | C | rs6078938 | 23648065 | 1.96E-05 | Dominant model | 2.06 | [1.45-2.92] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6078938-C | Research Support, Non-U.S. Gov't |
| 20 | 13143562 | rs7264061 | A | C | rs7264061 | 23648065 | 5.65E-05 | Dominant model | 1.97 | [1.39-2.78] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs7264061-G | Research Support, Non-U.S. Gov't |
| 20 | 16045679 | rs775122 | A | G | rs775122 | 23648065 | 9.03E-05 | Allelic model | 2.57 | [1.61-4.09] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs775122-A | Research Support, Non-U.S. Gov't |
| 20 | 19414947 | rs6136727 | G | A | rs6136727 | pha003095 | 7.07E-06 | phs000221 | phs000501 | 0.25 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6136727-A | NA |
| 20 | 19420941 | rs2328385 | C | T | rs2328385 | pha003095 | 1.74E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2328385-T | NA |
| 20 | 19437539 | rs6081600 | A | G | rs6081600 | pha003095 | 2.03E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6081600-A | NA |
| 20 | 19440011 | rs6035345 | C | T | rs6035345 | pha003095 | 1.93E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6035345-C | NA |
| 20 | 19441650 | rs3790217 | A | C | rs3790217 | pha003095 | 1.64E-05 | phs000221 | phs000501 | 0.23 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs3790217-A | NA |
| 20 | 19442549 | rs6046109 | A | G | rs6046109 | pha003095 | 6.67E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs6046109-A | NA |
| 20 | 19449783 | rs2206638 | A | G | rs2206638 | pha003095 | 5.19E-05 | phs000221 | phs000501 | 0.21 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2206638-A | NA |
| 20 | 22431290 | rs11907086 | A | G | rs11907086 | 23648065 | 5.38E-05 | Recessive model | 1.63 | [1.12-2.39] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11907086-G | Research Support, Non-U.S. Gov't |
| 20 | 23011468 | rs11696134 | A | G | rs11696134 | 23648065 | 7.50E-05 | Dominant model | 1.53 | [1.17-2.00] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs11696134-T | Research Support, Non-U.S. Gov't |
| 20 | 31366243 | rs6141813 | A | G | rs6141813 | 23648065 | 9.55E-05 | Dominant model | 1.42 | [1.08-1.86] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6141813-T | Research Support, Non-U.S. Gov't |
| 20 | 31402217 | rs853858 | G | A | rs853858 | 23648065 | 6.99E-05 | Dominant model | 1.45 | [1.10-1.90] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs853858-A | Research Support, Non-U.S. Gov't |
| 20 | 36997632 | rs1780627 | T | C | rs1780627 | 23648065 | 6.56E-05 | Dominant model | 1.55 | [1.23-1.96] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1780627-T | Research Support, Non-U.S. Gov't |
| 20 | 39611802 | rs734532 | G | A | rs734532 | 23648065 | 3.33E-05 | Allelic model | 2.38 | [1.61-3.52] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs734532-C | Research Support, Non-U.S. Gov't |
| 20 | 46566785 | rs2426053 | C | A | rs2426053 | 23648065 | 5.44E-05 | Allelic model | 1.68 | [1.31-2.15] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2426053-G | Research Support, Non-U.S. Gov't |
| 20 | 47110130 | rs6012446 | C | T | rs6012446 | 23648065 | 1.69E-05 | Recessive model | 1.88 | [1.21-2.93] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6012446-G | Research Support, Non-U.S. Gov't |
| 20 | 47110130 | rs6012446 | C | T | rs6012446 | 23648065 | 5.16E-05 | Recessive model | 1.48 | [1.04-2.12] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6012446-G | Research Support, Non-U.S. Gov't |
| 20 | 47144037 | rs1321010 | C | T | rs1321010 | 23648065 | 2.81E-05 | Recessive model | 1.84 | [1.20-2.84] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1321010-C | Research Support, Non-U.S. Gov't |
| 20 | 52551750 | rs16998568 | C | T | rs16998568 | 23648065 | 3.05E-05 | Dominant model | 2.2 | [1.39-3.49] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs16998568-A | Research Support, Non-U.S. Gov't |
| 20 | 54239617 | rs1337245 | A | G | rs1337245 | 23648065 | 6.74E-05 | Allelic model | 1.66 | [1.30-2.12] | 261 Japanese ancestry cases; 262 Japanese ancestry controls | Japanese(523) | ALL(523) | ASN(523) | ALL(523) | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1337245-C | Research Support, Non-U.S. Gov't |
| 20 | 55252119 | rs4811724 | C | T | rs4811724 | 23648065 | 4.79E-05 | Recessive model | 1.32 | [1.01-1.72] | 177 Japanese ancestry cases; 952 Japanese ancestry controls | Japanese(1129) | ALL(1129) | ASN(1129) | ALL(1129) | Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4811724-A | Research Support, Non-U.S. Gov't |
| 20 | 59185488 | rs6128870 | G | A | rs6128870 | 23648065 | 2.48E-05 | Recessive model | 1.7 | [1.27-2.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs6128870-A | Research Support, Non-U.S. Gov't |
| 20 | 59315127 | rs1202031 | A | G | rs1202031 | 23648065 | 1.21E-05 | Recessive model | 1.53 | [1.20-1.95] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1202031-C | Research Support, Non-U.S. Gov't |
| 20 | 59348278 | rs1885008 | T | C | rs1885008 | pha003095 | 4.64E-05 | phs000221 | phs000501 | 0.27 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1885008-C | NA |
| 20 | 59350288 | rs1202075 | C | T | rs1202075 | pha003095 | 3.49E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1202075-C | NA |
| 20 | 59352330 | rs1629243 | A | G | rs1629243 | pha003095 | 3.49E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs1629243-A | NA |
| 20 | 60097129 | rs767725 | A | G | rs767725 | 23648065 | 2.23E-05 | Dominant model | 1.45 | [1.20-1.77] | 371 Japanese ancestry cases; 825 Japanese ancestry controls | Japanese(1196) | ALL(1196) | ASN(1196) | ALL(1196) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs767725-A | Research Support, Non-U.S. Gov't |
| 21 | 19481354 | rs2055011 | G | A | rs2055011 | 23648065 | 9.00E-06 | Recessive model | 1.35 | [1.08-1.69] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2055011-C | Research Support, Non-U.S. Gov't |
| 21 | 19481895 | rs1491783 | T | C | rs1491783 | 23648065 | 4.68E-05 | Recessive model | 1.37 | [1.09-1.71] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1491783-T | Research Support, Non-U.S. Gov't |
| 21 | 20740552 | rs2825544 | T | C | rs2825544 | 23648065 | 7.78E-05 | Recessive model | 1.59 | [1.12-2.25] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2825544-T | Research Support, Non-U.S. Gov't |
| 21 | 20773423 | rs2825560 | T | C | rs2825560 | 23648065 | 1.46E-05 | Recessive model | 1.64 | [1.15-2.32] | 106 Japanese ancestry cases; 187 Japanese ancestry controls | Japanese(293) | ALL(293) | ASN(293) | ALL(293) | Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2825560-T | Research Support, Non-U.S. Gov't |
| 21 | 21804099 | rs8133125 | G | A | rs8133125 | 23648065 | 2.27E-05 | Dominant model | 1.61 | [1.24-2.08] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8133125-C | Research Support, Non-U.S. Gov't |
| 21 | 26825565 | rs2829750 | G | A | rs2829750 | 23648065 | 2.58E-05 | Dominant model | 1.53 | [1.23-1.91] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2829750-C | Research Support, Non-U.S. Gov't |
| 21 | 26826514 | rs8127977 | T | C | rs8127977 | 23648065 | 2.00E-06 | Dominant model | 1.59 | [1.28-1.97] | 294 Japanese ancestry cases; 2,249 Japanese ancestry controls | Japanese(2543) | ALL(2543) | ASN(2543) | ALL(2543) | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8127977-A | Research Support, Non-U.S. Gov't |
| 21 | 31460885 | rs10432780 | A | G | rs10432780 | 23648065 | 9.83E-05 | Recessive model | 1.47 | [1.04-2.08] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs10432780-C | Research Support, Non-U.S. Gov't |
| 21 | 33437648 | rs4817450 | T | C | rs4817450 | 23648065 | 2.22E-05 | Recessive model | 1.31 | [0.95-1.81] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4817450-T | Research Support, Non-U.S. Gov't |
| 21 | 37120781 | rs2835123 | A | G | rs2835123 | 23648065 | 9.19E-05 | Dominant model | 1.7 | [1.23-2.33] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2835123-C | Research Support, Non-U.S. Gov't |
| 21 | 40489027 | rs2836891 | C | T | rs2836891 | 23648065 | 4.51E-05 | Recessive model | 2.11 | [1.36-3.28] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2836891-G | Research Support, Non-U.S. Gov't |
| 21 | 41278302 | rs2244189 | C | T | rs2244189 | 23648065 | 4.69E-05 | Allelic model | 7.1 | [2.53-19.92] | 54 Japanese ancestry cases; 39 Japanese ancestry controls | Japanese(93) | ALL(93) | ASN(93) | ALL(93) | Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs2244189-G | Research Support, Non-U.S. Gov't |
| 21 | 42105119 | rs13049429 | T | C | rs13049429 | 23648065 | 7.90E-05 | Dominant model | 2.61 | [1.52-4.48] | 176 Japanese ancestry cases; 471 Japanese ancestry controls | Japanese(647) | ALL(647) | ASN(647) | ALL(647) | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13049429-T | Research Support, Non-U.S. Gov't |
| 21 | 42174960 | rs2837828 | A | G | rs2837828 | 21507922 | 1.00E-06 | NA | NA | NA | 115 African ancestry HIV-negative individuals | African(115) | ALL(115) | AFR(115) | ALL(115) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | NA |
| 21 | 42485808 | rs13050861 | A | G | rs13050861 | 23648065 | 5.16E-05 | Allelic model | 2.11 | [1.48-3.03] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs13050861-G | Research Support, Non-U.S. Gov't |
| 21 | 43674122 | rs225376 | G | C | rs225376 | 23648065 | 7.05E-05 | Allelic model | 2.01 | [1.43-2.84] | 83 Japanese ancestry cases; 370 Japanese ancestry controls | Japanese(453) | ALL(453) | ASN(453) | ALL(453) | Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs225376-C | Research Support, Non-U.S. Gov't |
| 21 | 46505979 | rs870144 | A | C | rs870144 | pha003095 | 6.15E-05 | phs000221 | phs000501 | 0.24 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs870144-C | NA |
| 22 | 17318150 | rs165611 | T | C | rs165611 | 23648065 | 8.13E-05 | Recessive model | 2.27 | [1.47-3.49] | 59 Japanese ancestry cases; 155 Japanese ancestry controls | Japanese(214) | ALL(214) | ASN(214) | ALL(214) | Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs165611-T | Research Support, Non-U.S. Gov't |
| 22 | 19692751 | rs8142156 | C | T | rs8142156 | 23648065 | 9.12E-05 | Dominant model | 2.53 | [1.53-4.17] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs8142156-G | Research Support, Non-U.S. Gov't |
| 22 | 19694333 | rs9618670 | C | T | rs9618670 | 23648065 | 9.12E-05 | Dominant model | 2.53 | [1.53-4.17] | 184 Japanese ancestry cases; 459 Japanese ancestry controls | Japanese(643) | ALL(643) | ASN(643) | ALL(643) | Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9618670-C | Research Support, Non-U.S. Gov't |
| 22 | 21318433 | rs756875 | G | A | rs756875 | 23648065 | 6.65E-05 | Dominant model | 1.48 | [1.13-1.92] | 168 Japanese ancestry cases; 335 Japanese ancestry controls | Japanese(503) | ALL(503) | ASN(503) | ALL(503) | Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs756875-A | Research Support, Non-U.S. Gov't |
| 22 | 26729721 | rs4822706 | T | C | rs4822706 | pha003095 | 7.43E-05 | phs000221 | phs000501 | 0.26 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs4822706-C | NA |
| 22 | 31153276 | rs9609078 | G | A | rs9609078 | 23648065 | 4.00E-06 | Allelic model | 10.89 | [3.53-33.61] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9609078-T | Research Support, Non-U.S. Gov't |
| 22 | 33006503 | rs5749471 | A | C | rs5749471 | 23648065 | 1.50E-05 | Dominant model | 2.5 | [1.63-3.85] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs5749471-A | Research Support, Non-U.S. Gov't |
| 22 | 33013062 | rs9621508 | A | C | rs9621508 | 23648065 | 2.47E-05 | Allelic model | 2.46 | [1.60-3.78] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs9621508-T | Research Support, Non-U.S. Gov't |
| 22 | 34120608 | rs239319 | T | C | rs239319 | 23648065 | 1.89E-05 | Dominant model | 1.52 | [1.20-1.93] | 218 Japanese ancestry cases; 364 Japanese controls | Japanese(582) | ALL(582) | ASN(582) | ALL(582) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs239319-G | Research Support, Non-U.S. Gov't |
| 22 | 35742524 | rs129433 | C | T | rs129433 | 23648065 | 1.03E-05 | Dominant model | 1.7 | [1.26-2.29] | 147 Japanese ancestry cases; 233 Japanese ancestry controls | Japanese(380) | ALL(380) | ASN(380) | ALL(380) | Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs129433-C | Research Support, Non-U.S. Gov't |
| 22 | 36517932 | rs1476029 | C | T | rs1476029 | 23648065 | 8.00E-06 | Allelic model | 6.43 | [2.43-17.00] | 150 Japanese ancestry cases; 166 Japanese ancestry controls | Japanese(316) | ALL(316) | ASN(316) | ALL(316) | Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs1476029-A | Research Support, Non-U.S. Gov't |
| 22 | 40034593 | rs2092179 | T | C | rs2092179 | pha003095 | 8.73E-05 | phs000221 | phs000501 | 0.22 | NA | NA | ALL(0) | ALL(0) | Neutrophil count | HPOID:0001874 | Abnormality of neutrophils | DOID:74 | DOID:526 | hematopoietic system disease | Human immunodeficiency virus infectious disease | D009503 | Neutropenia | EFOID:0004833 | neutrophil count | AIDS | Hematopoietic system disease | rs2092179-C | NA |
| 22 | 47557638 | rs4823603 | G | A | rs4823603 | 23648065 | 6.43E-05 | Recessive model | 1.86 | [1.26-2.76] | 80 Japanese ancestry cases; 226 Japanese ancestry controls | Japanese(306) | ALL(306) | ASN(306) | ALL(306) | Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) | HPOID:0001875 | HPOID:0001882 | Neutropenia | Leukopenia | DOID:1227 | neutropenia | NA | NA | NA | NA | Neutropenia | rs4823603-C | Research Support, Non-U.S. Gov't |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:126) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0023530 | acetaminophen | D000082 | 103-90-2 | leukopenia | MESH:D007970 | marker/mechanism | 18377375 | ||
| C0023530 | bleomycin | D001761 | 11056-06-7 | leukopenia | MESH:D007970 | marker/mechanism | 10526668 | ||
| C0023530 | busulfan | D002066 | 55-98-1 | leukopenia | MESH:D007970 | marker/mechanism | 3332186 | ||
| C0023530 | carbamazepine | D002220 | 298-46-4 | leukopenia | MESH:D007970 | marker/mechanism | 2089834 | ||
| C0023530 | carmustine | D002330 | 154-93-8 | leukopenia | MESH:D007970 | marker/mechanism | 4343318 | ||
| C0023530 | cefdinir | C056814 | - | leukopenia | MESH:D007970 | marker/mechanism | 18377375 | ||
| C0023530 | chlorambucil | D002699 | 305-03-3 | leukopenia | MESH:D007970 | marker/mechanism | 1206673 | ||
| C0023530 | chloramphenicol | D002701 | 56-75-7 | leukopenia | MESH:D007970 | marker/mechanism | 11295484 | ||
| C0023530 | chlorotrianisene | D002741 | 569-57-3 | leukopenia | MESH:D007970 | marker/mechanism | 1142528 | ||
| C0023530 | cimetidine | D002927 | 51481-61-9 | leukopenia | MESH:D007970 | marker/mechanism | 12601542 | ||
| C0023530 | ciprofloxacin | D002939 | 85721-33-1 | leukopenia | MESH:D007970 | therapeutic | 17846019 | ||
| C0023530 | clozapine | D003024 | 5786-21-0 | leukopenia | MESH:D007970 | marker/mechanism | 12095078 | ||
| C0023530 | colchicine | D003078 | 64-86-8 | leukopenia | MESH:D007970 | marker/mechanism | 16240705 | ||
| C0023530 | cyclophosphamide | D003520 | 50-18-0 | leukopenia | MESH:D007970 | marker/mechanism | 10052129 | ||
| C0023530 | dapsone | D003622 | 80-08-0 | leukopenia | MESH:D007970 | marker/mechanism | 11710542 | ||
| C0023530 | cisplatin | D002945 | 15663-27-1 | leukopenia | MESH:D007970 | marker/mechanism | 10396320 | ||
| C0023530 | doxycycline | D004318 | 564-25-0 | leukopenia | MESH:D007970 | marker/mechanism | 9145823 | ||
| C0023530 | epirubicin | D015251 | 56420-45-2 | leukopenia | MESH:D007970 | marker/mechanism | 10526668 | ||
| C0023530 | fluorouracil | D005472 | 51-21-8 | leukopenia | MESH:D007970 | marker/mechanism | 10396320 | ||
| C0023530 | leucovorin | D002955 | 1958/5/9 | leukopenia | MESH:D007970 | marker/mechanism | 12119460 | ||
| C0023530 | leucovorin | D002955 | 1958/5/9 | leukopenia | MESH:D007970 | therapeutic | 6607976 | ||
| C0023530 | gefitinib | C419708 | 184475-35-2 | leukopenia | MESH:D007970 | marker/mechanism | 15196742 | ||
| C0023530 | gemcitabine | C056507 | 103882-84-4 | leukopenia | MESH:D007970 | marker/mechanism | 11325490 | ||
| C0023530 | haloperidol | D006220 | 52-86-8 | leukopenia | MESH:D007970 | marker/mechanism | 4556089 | ||
| C0023530 | hydroxyurea | D006918 | 127-07-1 | leukopenia | MESH:D007970 | marker/mechanism | 1142528 | ||
| C0023530 | ifosfamide | D007069 | 3778-73-2 | leukopenia | MESH:D007970 | marker/mechanism | 1100226 | ||
| C0023530 | imipramine | D007099 | 50-49-7 | leukopenia | MESH:D007970 | marker/mechanism | 3578343 | ||
| C0023530 | indomethacin | D007213 | 53-86-1 | leukopenia | MESH:D007970 | marker/mechanism | 16240705 | ||
| C0023530 | melphalan | D008558 | 148-82-3 | leukopenia | MESH:D007970 | marker/mechanism | 3597002 | ||
| C0023530 | mesna | D015080 | 19767-45-4 | leukopenia | MESH:D007970 | marker/mechanism | 1677714 | ||
| C0023530 | mesna | D015080 | 19767-45-4 | leukopenia | MESH:D007970 | therapeutic | 1392448 | ||
| C0023530 | methotrexate | D008727 | 1959/5/2 | leukopenia | MESH:D007970 | marker/mechanism | 11135211 | ||
| C0023530 | methylphenidate | D008774 | 113-45-1 | leukopenia | MESH:D007970 | marker/mechanism | 7751253 | ||
| C0023530 | mitomycin | D016685 | 1950/7/7 | leukopenia | MESH:D007970 | marker/mechanism | 10928138 | ||
| C0023530 | mitoxantrone | D008942 | 65271-80-9 | leukopenia | MESH:D007970 | marker/mechanism | 11290867 | ||
| C0023530 | nafcillin | D009254 | 147-52-4 | leukopenia | MESH:D007970 | marker/mechanism | 7467307 | ||
| C0023530 | oxaliplatin | C030110 | - | leukopenia | MESH:D007970 | marker/mechanism | 15274380 | ||
| C0023530 | paclitaxel | D017239 | - | leukopenia | MESH:D007970 | marker/mechanism | 12601542 | ||
| C0023530 | pegfilgrastim | C455861 | - | leukopenia | MESH:D007970 | therapeutic | 17846019 | ||
| C0023530 | phenytoin | D010672 | 57-41-0 | leukopenia | MESH:D007970 | marker/mechanism | 1147459 | ||
| C0023530 | piperacillin | D010878 | 61477-96-1 | leukopenia | MESH:D007970 | marker/mechanism | 3945861 | ||
| C0023530 | pipobroman | D010885 | 54-91-1 | leukopenia | MESH:D007970 | marker/mechanism | 11736962 | ||
| C0023530 | propylthiouracil | D011441 | 51-52-5 | leukopenia | MESH:D007970 | marker/mechanism | 6179348 | ||
| C0023530 | ribavirin | D012254 | 36791-04-5 | leukopenia | MESH:D007970 | marker/mechanism | 10770762 | ||
| C0023530 | rifabutin | D017828 | 72559-06-9 | leukopenia | MESH:D007970 | marker/mechanism | 11310523 | ||
| C0023530 | sirolimus | D020123 | 53123-88-9 | leukopenia | MESH:D007970 | marker/mechanism | 10221490 | ||
| C0023530 | streptozocin | D013311 | 18883-66-4 | leukopenia | MESH:D007970 | marker/mechanism | 135666 | ||
| C0023530 | tacrolimus | D016559 | 109581-93-3 | leukopenia | MESH:D007970 | therapeutic | 10385251 | ||
| C0023530 | temozolomide | C047246 | 85622-93-1 | leukopenia | MESH:D007970 | marker/mechanism | 16648049 | ||
| C0023530 | teniposide | D013713 | 29767-20-2 | leukopenia | MESH:D007970 | marker/mechanism | 4609765 | ||
| C0023530 | thiotepa | D013852 | 52-24-4 | leukopenia | MESH:D007970 | marker/mechanism | 7786825 | ||
| C0023530 | valproic acid | D014635 | 99-66-1 | leukopenia | MESH:D007970 | marker/mechanism | 7864268 | ||
| C0023530 | vinblastine | D014747 | 865-21-4 | leukopenia | MESH:D007970 | marker/mechanism | 3686684 | ||
| C0023530 | vincristine | D014750 | - | leukopenia | MESH:D007970 | marker/mechanism | 2997407 | ||
| C0023530 | vindesine | D014751 | 53643-48-4 | leukopenia | MESH:D007970 | marker/mechanism | 10928138 | ||
| C0023530 | vinorelbine | C030852 | 71486-22-1 | leukopenia | MESH:D007970 | marker/mechanism | 15196742 | ||
| C0023530 | zidovudine | D015215 | 30516-87-1 | leukopenia | MESH:D007970 | marker/mechanism | 2257294 | ||
| C0023530 | allopurinol | D000493 | 315-30-0 | neutropenia | MESH:D009503 | therapeutic | 6457698 | ||
| C0023530 | amifostine | D004999 | 20537-88-6 | neutropenia | MESH:D009503 | marker/mechanism | 10812192 | ||
| C0023530 | amodiaquine | D000655 | 86-42-0 | neutropenia | MESH:D009503 | marker/mechanism | 974497 | ||
| C0023530 | bleomycin | D001761 | 11056-06-7 | neutropenia | MESH:D009503 | marker/mechanism | 10526668 | ||
| C0023530 | bortezomib | D000069286 | - | neutropenia | MESH:D009503 | marker/mechanism | 16763792 | ||
| C0023530 | busulfan | D002066 | 55-98-1 | neutropenia | MESH:D009503 | marker/mechanism | 16543071 | ||
| C0023530 | carbamazepine | D002220 | 298-46-4 | neutropenia | MESH:D009503 | marker/mechanism | 9855327 | ||
| C0023530 | carbimazole | D002231 | 22232-54-8 | neutropenia | MESH:D009503 | marker/mechanism | 10848805 | ||
| C0023530 | carmustine | D002330 | 154-93-8 | neutropenia | MESH:D009503 | marker/mechanism | 12494480 | ||
| C0023530 | caspofungin | C105417 | - | neutropenia | MESH:D009503 | therapeutic | 20606829 | ||
| C0023530 | chlorambucil | D002699 | 305-03-3 | neutropenia | MESH:D009503 | marker/mechanism | 2797556 | ||
| C0023530 | cladribine | D017338 | 4291-63-8 | neutropenia | MESH:D009503 | marker/mechanism | 15654901 | ||
| C0023530 | cidofovir | C059262 | 113852-37-2 | neutropenia | MESH:D009503 | marker/mechanism | 12093990 | ||
| C0023530 | cimetidine | D002927 | 51481-61-9 | neutropenia | MESH:D009503 | marker/mechanism | 12601542 | ||
| C0023530 | ciprofloxacin | D002939 | 85721-33-1 | neutropenia | MESH:D009503 | therapeutic | 17846019 | ||
| C0023530 | clozapine | D003024 | 5786-21-0 | neutropenia | MESH:D009503 | marker/mechanism | 10340918 | ||
| C0023530 | crizotinib | C551994 | - | neutropenia | MESH:D009503 | marker/mechanism | 22954507 | ||
| C0023530 | cyclophosphamide | D003520 | 50-18-0 | neutropenia | MESH:D009503 | marker/mechanism | 10526668 | ||
| C0023530 | cyclosporine | D016572 | 59865-13-3 | neutropenia | MESH:D009503 | marker/mechanism | 7666081 | ||
| C0023530 | cisplatin | D002945 | 15663-27-1 | neutropenia | MESH:D009503 | marker/mechanism | 10812192 | ||
| C0023530 | cisplatin | D002945 | 15663-27-1 | neutropenia | MESH:D009503 | therapeutic | 24158386 | ||
| C0023530 | doxycycline | D004318 | 564-25-0 | neutropenia | MESH:D009503 | marker/mechanism | 9145823 | ||
| C0023530 | epirubicin | D015251 | 56420-45-2 | neutropenia | MESH:D009503 | marker/mechanism | 10526668 | ||
| C0023530 | filgrastim | D000069585 | - | neutropenia | MESH:D009503 | therapeutic | 15597026 | ||
| C0023530 | fluorouracil | D005472 | 51-21-8 | neutropenia | MESH:D009503 | marker/mechanism | 11432626 | ||
| C0023530 | folic acid | D005492 | 59-30-3 | neutropenia | MESH:D009503 | therapeutic | 16322990 | ||
| C0023530 | leucovorin | D002955 | 1958/5/9 | neutropenia | MESH:D009503 | marker/mechanism | 11432626 | ||
| C0023530 | foscarnet | D017245 | 4428-95-9 | neutropenia | MESH:D009503 | marker/mechanism | 7802522 | ||
| C0023530 | ganciclovir | D015774 | 82410-32-0 | neutropenia | MESH:D009503 | marker/mechanism | 12915819 | ||
| C0023530 | gefitinib | C419708 | 184475-35-2 | neutropenia | MESH:D009503 | marker/mechanism | 15196742 | ||
| C0023530 | gemcitabine | C056507 | 103882-84-4 | neutropenia | MESH:D009503 | marker/mechanism | 10526274 | ||
| C0023530 | ifosfamide | D007069 | 3778-73-2 | neutropenia | MESH:D009503 | marker/mechanism | 11290867 | ||
| C0023530 | lenalidomide | C467567 | - | neutropenia | MESH:D009503 | marker/mechanism | 17723971 | ||
| C0023530 | linezolid | D000069349 | - | neutropenia | MESH:D009503 | marker/mechanism | 14520145 | ||
| C0023530 | melphalan | D008558 | 148-82-3 | neutropenia | MESH:D009503 | marker/mechanism | 10656432 | ||
| C0023530 | methotrexate | D008727 | 1959/5/2 | neutropenia | MESH:D009503 | marker/mechanism | 16246977 | ||
| C0023530 | mitomycin | D016685 | 1950/7/7 | neutropenia | MESH:D009503 | marker/mechanism | 15724837 | ||
| C0023530 | mitoxantrone | D008942 | 65271-80-9 | neutropenia | MESH:D009503 | marker/mechanism | 10597740 | ||
| C0023530 | nafcillin | D009254 | 147-52-4 | neutropenia | MESH:D009503 | marker/mechanism | 7467307 | ||
| C0023530 | octreotide | D015282 | 83150-76-9 | neutropenia | MESH:D009503 | marker/mechanism | 20857844 | ||
| C0023530 | olanzapine | C076029 | 132539-06-1 | neutropenia | MESH:D009503 | marker/mechanism | 20176014 | ||
| C0023530 | oxaliplatin | C030110 | - | neutropenia | MESH:D009503 | marker/mechanism | 11432626 | ||
| C0023530 | paclitaxel | D017239 | - | neutropenia | MESH:D009503 | marker/mechanism | 10472783 | ||
| C0023530 | paclitaxel | D017239 | - | neutropenia | MESH:D009503 | therapeutic | 16332718 | ||
| C0023530 | pefloxacin | D015366 | 70458-92-3 | neutropenia | MESH:D009503 | therapeutic | 1524911 | ||
| C0023530 | pegfilgrastim | C455861 | - | neutropenia | MESH:D009503 | marker/mechanism | 14565651 | ||
| C0023530 | pegfilgrastim | C455861 | - | neutropenia | MESH:D009503 | therapeutic | 16293865 | ||
| C0023530 | peginterferon alfa-2b | C417083 | - | neutropenia | MESH:D009503 | marker/mechanism | 16462543 | ||
| C0023530 | phenytoin | D010672 | 57-41-0 | neutropenia | MESH:D009503 | marker/mechanism | 9855327 | ||
| C0023530 | piperacillin | D010878 | 61477-96-1 | neutropenia | MESH:D009503 | therapeutic | 1524911 | ||
| C0023530 | propylthiouracil | D011441 | 51-52-5 | neutropenia | MESH:D009503 | marker/mechanism | 12521217 | ||
| C0023530 | quinine | D011803 | 130-95-0 | neutropenia | MESH:D009503 | marker/mechanism | 1421383 | ||
| C0023530 | raltitrexed | C068874 | - | neutropenia | MESH:D009503 | marker/mechanism | 11528249 | ||
| C0023530 | ribavirin | D012254 | 36791-04-5 | neutropenia | MESH:D009503 | marker/mechanism | 15081101 | ||
| C0023530 | ritonavir | D019438 | - | neutropenia | MESH:D009503 | marker/mechanism | 17378895 | ||
| C0023530 | temozolomide | C047246 | 85622-93-1 | neutropenia | MESH:D009503 | marker/mechanism | 15360003 | ||
| C0023530 | temsirolimus | C401859 | - | neutropenia | MESH:D009503 | marker/mechanism | 20430774 | ||
| C0023530 | thalidomide | D013792 | 50-35-1 | neutropenia | MESH:D009503 | marker/mechanism | 10871741 | ||
| C0023530 | thiotepa | D013852 | 52-24-4 | neutropenia | MESH:D009503 | marker/mechanism | 9676843 | ||
| C0023530 | ticlopidine | D013988 | 55142-85-3 | neutropenia | MESH:D009503 | marker/mechanism | 1448821 | ||
| C0023530 | trabectedin | C099150 | 114899-77-3 | neutropenia | MESH:D009503 | marker/mechanism | 20406837 | ||
| C0023530 | tretinoin | D014212 | 302-79-4 | neutropenia | MESH:D009503 | marker/mechanism | 20060166 | ||
| C0023530 | valproic acid | D014635 | 99-66-1 | neutropenia | MESH:D009503 | marker/mechanism | 17195721 | ||
| C0023530 | vancomycin | D014640 | 1404-90-6 | neutropenia | MESH:D009503 | marker/mechanism | 14520145 | ||
| C0023530 | vinblastine | D014747 | 865-21-4 | neutropenia | MESH:D009503 | marker/mechanism | 11104554 | ||
| C0023530 | vincristine | D014750 | - | neutropenia | MESH:D009503 | marker/mechanism | 11305414 | ||
| C0023530 | vindesine | D014751 | 53643-48-4 | neutropenia | MESH:D009503 | marker/mechanism | 6707719 | ||
| C0023530 | vinorelbine | C030852 | 71486-22-1 | neutropenia | MESH:D009503 | marker/mechanism | 10526274 | ||
| C0023530 | zidovudine | D015215 | 30516-87-1 | neutropenia | MESH:D009503 | marker/mechanism | 11710542 | ||
FDA approved drug and dosage information(Total Drugs:30) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D009503 | zyvox | linezolid | 400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET;ORAL | Discontinued | None | Yes | No |
| MESH:D009503 | zyvox | linezolid | 200MG/100ML (2MG/ML) | SOLUTION;IV (INFUSION) | Prescription | AP | Yes | No |
| MESH:D009503 | zyvox | linezolid | 100MG/5ML | FOR SUSPENSION;ORAL | Prescription | AB | Yes | Yes |
| MESH:D009503 | zyvox | linezolid | 400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET;ORAL | Discontinued | None | Yes | No |
| MESH:D009503 | zyvox | linezolid | 200MG/100ML (2MG/ML) | SOLUTION;IV (INFUSION) | Prescription | AP | Yes | No |
| MESH:D009503 | zyvox | linezolid | 100MG/5ML | FOR SUSPENSION;ORAL | Prescription | AB | Yes | Yes |
| MESH:D009503 | busulfex | busulfan | 6MG/ML | INJECTABLE;INJECTION | Prescription | AP | Yes | Yes |
| MESH:D009503 | temodar | temozolomide | 5MG | CAPSULE;ORAL | Prescription | AB | Yes | No |
| MESH:D009503 | temodar | temozolomide | 100MG/VIAL | POWDER;INTRAVENOUS | Prescription | None | Yes | Yes |
| MESH:D009503 | cipro | ciprofloxacin | 400MG/40ML (10MG/ML) | INJECTABLE;INJECTION | Discontinued | None | Yes | No |
| MESH:D009503 | cipro | ciprofloxacin | 250MG/5ML | FOR SUSPENSION;ORAL | Prescription | AB | Yes | No |
| MESH:D009503 | norvir | ritonavir | 80MG/ML | SOLUTION;ORAL | Prescription | None | Yes | Yes |
| MESH:D009503 | norvir | ritonavir | 100MG | CAPSULE;ORAL | Discontinued | None | No | No |
| MESH:D009503 | norvir | ritonavir | 100MG | CAPSULE;ORAL | Prescription | None | Yes | Yes |
| MESH:D009503 | norvir | ritonavir | 100MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D009503 | eloxatin | oxaliplatin | 50MG/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | INJECTABLE;IV (INFUSION) | Discontinued | None | Yes | No |
| MESH:D009503 | eloxatin | oxaliplatin | 50MG/10ML (5MG/ML) | INJECTABLE;IV (INFUSION) | Prescription | AP | Yes | Yes |
| MESH:D009503 | oxaliplatin | oxaliplatin | 50MG/10ML (5MG/ML) | INJECTABLE;IV (INFUSION) | Prescription | AP | Yes | Yes |
| MESH:D009503 | zyprexa | olanzapine | 2.5MG | TABLET;ORAL | Prescription | AB | Yes | No |
| MESH:D009503 | zyprexa | olanzapine | 10MG/VIAL | INJECTABLE;INTRAMUSCULAR | Prescription | AP | Yes | Yes |
| MESH:D009503 | zyprexa | olanzapine | 2.5MG | TABLET;ORAL | Prescription | AB | Yes | No |
| MESH:D009503 | zyprexa | olanzapine | 10MG/VIAL | INJECTABLE;INTRAMUSCULAR | Prescription | AP | Yes | Yes |
| MESH:D009503 | retrovir | zidovudine | 100MG | CAPSULE;ORAL | Prescription | AB | Yes | Yes |
| MESH:D009503 | retrovir | zidovudine | 50MG/5ML | SYRUP;ORAL | Prescription | AA | Yes | Yes |
| MESH:D009503 | retrovir | zidovudine | 10MG/ML | INJECTABLE;INJECTION | Prescription | AP | Yes | Yes |
| MESH:D009503 | retrovir | zidovudine | 200MG | TABLET;ORAL | Discontinued | None | No | No |
| MESH:D009503 | zidovudine | zidovudine | 60MG | TABLET;ORAL | Discontinued | None | No | No |
| MESH:D009503 | zidovudine | zidovudine | 60MG | TABLET;ORAL | Discontinued | None | No | No |
| MESH:D009503 | torisel | temsirolimus | 25MG/ML (25MG/ML) | SOLUTION;INTRAVENOUS | Prescription | None | Yes | Yes |
| MESH:D009503 | velcade | bortezomib | 3.5MG/VIAL | INJECTABLE;INTRAVENOUS, SUBCUTANEOUS | Prescription | None | Yes | Yes |
FDA labeling changes(Total Drugs:30) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D009503 | 12/19/2002 | zyvox | linezolid | Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains | Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 12/19/2002 | zyvox | linezolid | Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains | Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 12/19/2002 | zyvox | linezolid | Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains | Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 12/5/2005 | zyvox | linezolid | Central nervous system infections | PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 12/5/2005 | zyvox | linezolid | Central nervous system infections | PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 12/5/2005 | zyvox | linezolid | Central nervous system infections | PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium | Labeling | B | - | - | - | Pfizer | 11/2/2005 | FALSE' |
| MESH:D009503 | 01/13/2003 | busulfex | busulfan | Part of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseases | The population pharmacokinetic estimates of busulfan for clearance and volume of distribution were determined in an open-label, uncontrolled PK study in 24 pediatric patients 5 months to 16 years who received busulfan as part of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseases Suggested dosing regimen | Labeling | B | - | - | - | Orphan Medical | 12/3/2002 | FALSE' |
| MESH:D009503 | 11/3/2003 | temodar | temozolomide | Recurrent CNS tumors | Temozolomide effectiveness in children has not been demonstrated New data from 2 open-label Phase 2 studies in pediatric patients 3-18 years of age. In one study there were 29 patients with recurrent brain stem glioma and 34 patients with recurrent high grade astrocyoma. In a second study there were 122 patients enrolled with various types of tumors; 113 CNS tumors and 9 non-CNS tumors. The temozolomide toxicity profile in children is similar to adults | Labeling | B | - | - | - | Schering | 11/20/2002 | FALSE' |
| MESH:D009503 | 11/3/2003 | temodar | temozolomide | Recurrent CNS tumors | Temozolomide effectiveness in children has not been demonstrated New data from 2 open-label Phase 2 studies in pediatric patients 3-18 years of age. In one study there were 29 patients with recurrent brain stem glioma and 34 patients with recurrent high grade astrocyoma. In a second study there were 122 patients enrolled with various types of tumors; 113 CNS tumors and 9 non-CNS tumors. The temozolomide toxicity profile in children is similar to adults | Labeling | B | - | - | - | Schering | 11/20/2002 | FALSE' |
| MESH:D009503 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |
| MESH:D009503 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |
| MESH:D009503 | 6/10/2005 | norvir | ritonavir | Treatment of HIV-infection in combination with other antiretroviral agents | Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters | Labeling | B | - | - | - | Abbott | 06/14/2005 | FALSE' |
| MESH:D009503 | 6/10/2005 | norvir | ritonavir | Treatment of HIV-infection in combination with other antiretroviral agents | Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters | Labeling | B | - | - | - | Abbott | 06/14/2005 | FALSE' |
| MESH:D009503 | 6/10/2005 | norvir | ritonavir | Treatment of HIV-infection in combination with other antiretroviral agents | Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters | Labeling | B | - | - | - | Abbott | 06/14/2005 | FALSE' |
| MESH:D009503 | 6/10/2005 | norvir | ritonavir | Treatment of HIV-infection in combination with other antiretroviral agents | Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters | Labeling | B | - | - | - | Abbott | 06/14/2005 | FALSE' |
| MESH:D009503 | 10/1/2007 | eloxatin | oxaliplatin | Solid tumors | The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs | Labeling | B | - | - | - | Sanofi-Aventis | 09/27/2006 | FALSE' |
| MESH:D009503 | 10/1/2007 | eloxatin | oxaliplatin | Solid tumors | The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs | Labeling | B | - | - | - | Sanofi-Aventis | 09/27/2006 | FALSE' |
| MESH:D009503 | 10/1/2007 | eloxatin | oxaliplatin | Solid tumors | The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs | Labeling | B | - | - | - | Sanofi-Aventis | 09/27/2006 | FALSE' |
| MESH:D009503 | 08/14/2008 | zyprexa | olanzapine | schizophrenia; bipolar disorder | Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg | - | B | - | - | - | Lilly | 10/1/2007 | FALSE' |
| MESH:D009503 | 08/14/2008 | zyprexa | olanzapine | schizophrenia; bipolar disorder | Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg | - | B | - | - | - | Lilly | 10/1/2007 | FALSE' |
| MESH:D009503 | 4/12/2009 | zyprexa | olanzapine | Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17 | Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies | Labeling | B | - | - | - | Lilly | 10/1/2007 | TRUE' |
| MESH:D009503 | 4/12/2009 | zyprexa | olanzapine | Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17 | Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies | Labeling | B | - | - | - | Lilly | 10/1/2007 | TRUE' |
| MESH:D009503 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 09/19/2008 | retrovir syrup, capsules and tablets | zidovudine | Used in combination with 18 other antiretroviral agents for the treatment of HIV-1 infection | Dosing and administration information provided to children 6 weeks to less than 18 years of age Macrocytosis was reported in the majority of pediatric patients receiving Retrovir 180 mg/m2 every 6 hours in open-label studies New dosing regimen | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D009503 | 05/30/2012 | torisel | temsirolimus | Advanced recurrent/refractory solid tumors | Effectiveness in pediatric patients has not been established Torisel was studied in 59 patients 1 - 17 years and 12 patients 18 to 21 years in a phase 1-2 safety and exploratory pharmacodynamic study Adverse reactions were similar to those observedd in adults Information on dosing, clinical trials and PK parameters | Labeling | B | - | - | - | - | - | FALSE' |
| MESH:D009503 | 09/14/2015 | velcade | bortezomib | Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL) | Effectiveness in pediatric patients with relapsed pre-B ALL has not been established. The activity and safety of Velcade in combination with intensive reinduction chemotherapy was evaluated in pediatric and young adult patients with lymphoid malignancies. There were 140 patients with ALL or LL enrolled and evaluated for safety. No new safety concerns were observed | Labeling | B | - | - | - | Millennium Pharmaceuticals, Inc. | - | FALSE |