PedAM

Pediatric Disease Annotations & Medicines


	neurogenic bladder

Disease ID	1276
Disease	neurogenic bladder
Definition	dysfunction of the urinary bladder due to disease of the central or peripheral nervous system pathways involved in the control of micturition.
Synonym	bladder dis neurogenic bladder disorder, neurogenic bladder neurogenic bladder, neurogenic neurogenic bladder (finding) neurogenic bladder dis neurogenic bladder disorder neurogenic bladder disorders neurogenic bladder nos neurogenic dysfunction of the urinary bladder neurogenic dysfunction of the urinary bladder (finding) neurogenic urinary bladder neurogenic urinary bladder dis neurogenic urinary bladder disorder neuropathic bladder neuropathic bladder (disorder) urinary bladder dis neurogenic urinary bladder disorder, neurogenic urinary bladder neurogenic dysfunction urinary bladder, neurogenic urinary bladder, neurogenic [disease/finding]
DOID	DOID:12143
UMLS	C0005697
MeSH	D001750
SNOMED-CT	SNOMEDCT_US_2016_09_01:397732007;SNOMEDCT_US_2016_09_01:398064005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:31) C0080178 \| spina bifida \| 5 C0042580 \| vesicoureteral reflux \| 3 C0020295 \| hydronephrosis \| 2 C0005683 \| bladder stone \| 2 C0080178 \| spinal dysraphism \| 2 C0026769 \| multiple sclerosis \| 2 C1561644 \| chronic kidney disease (ckd) \| 1 C0005694 \| bladder outlet obstruction \| 1 C0011849 \| diabetes mellitus \| 1 C0030305 \| pancreatitis \| 1 C0037928 \| myelopathy \| 1 C0700101 \| urethral ca \| 1 C0027765 \| neurological disease \| 1 C0392548 \| cauda equina syndrome \| 1 C0037928 \| myelopathies \| 1 C0178879 \| obstructive uropathy \| 1 C0005684 \| bladder cancer \| 1 C0004659 \| bacteriuria \| 1 C0376358 \| prostate cancer \| 1 C0024198 \| lyme disease \| 1 C0043019 \| lateral medullary syndrome \| 1 C0011860 \| type ii diabetes mellitus \| 1 C0265343 \| vertebral anomalies \| 1 C2004461 \| bowel dysfunction \| 1 C0042075 \| uropathy \| 1 C0026975 \| myelitis \| 1 C0011847 \| diabetes \| 1 C0011860 \| type ii diabetes \| 1 C0042267 \| vaginitis \| 1 C0010692 \| cystitis \| 1 C0039223 \| tabes dorsalis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) CHRM2 \| 1129 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:117) 126393 \| HSPB6 \| DISEASES 440 \| ASNS \| DISEASES 6583 \| SLC22A4 \| DISEASES 26517 \| TIMM13 \| DISEASES 7380 \| UPK3A \| DISEASES 10598 \| AHSA1 \| DISEASES 51285 \| RASL12 \| DISEASES 9333 \| TGM5 \| DISEASES 7040 \| TGFB1 \| DISEASES 5023 \| P2RX1 \| DISEASES 952 \| CD38 \| DISEASES 24145 \| PANX1 \| DISEASES 55640 \| FLVCR2 \| DISEASES 54800 \| KLHL24 \| DISEASES 30833 \| NT5C \| DISEASES 7408 \| VASP \| DISEASES 2006 \| ELN \| DISEASES 10343 \| PKDREJ \| DISEASES 6616 \| SNAP25 \| DISEASES 3508 \| IGHMBP2 \| DISEASES 1131 \| CHRM3 \| DISEASES 57498 \| KIDINS220 \| DISEASES 187 \| APLNR \| DISEASES 10017 \| BCL2L10 \| DISEASES 4223 \| MEOX2 \| DISEASES 5024 \| P2RX3 \| DISEASES 492 \| ATP2B3 \| DISEASES 3299 \| HSF4 \| DISEASES 590 \| BCHE \| DISEASES 2247 \| FGF2 \| DISEASES 793 \| CALB1 \| DISEASES 51083 \| GAL \| DISEASES 55749 \| CCAR1 \| DISEASES 150094 \| SIK1 \| DISEASES 6282 \| S100A11 \| DISEASES 4915 \| NTRK2 \| DISEASES 6876 \| TAGLN \| DISEASES 2697 \| GJA1 \| DISEASES 8209 \| C21orf33 \| DISEASES 4760 \| NEUROD1 \| DISEASES 6228 \| RPS23 \| DISEASES 6866 \| TAC3 \| DISEASES 4054 \| LTBP3 \| DISEASES 5368 \| PNOC \| DISEASES 79058 \| ASPSCR1 \| DISEASES 5734 \| PTGER4 \| DISEASES 6870 \| TACR3 \| DISEASES 6869 \| TACR1 \| DISEASES 171558 \| PTCRA \| DISEASES 5354 \| PLP1 \| DISEASES 10855 \| HPSE \| DISEASES 81839 \| VANGL1 \| DISEASES 354 \| KLK3 \| DISEASES 1909 \| EDNRA \| DISEASES 64755 \| C16orf58 \| DISEASES 4026 \| LPP \| DISEASES 27319 \| BHLHE22 \| DISEASES 58492 \| ZNF77 \| DISEASES 10938 \| EHD1 \| DISEASES 6863 \| TAC1 \| DISEASES 547 \| KIF1A \| DISEASES 2027 \| ENO3 \| DISEASES 3052 \| HCCS \| DISEASES 5813 \| PURA \| DISEASES 9939 \| RBM8A \| DISEASES 10052 \| GJC1 \| DISEASES 23396 \| PIP5K1C \| DISEASES 4987 \| OPRL1 \| DISEASES 3363 \| HTR7 \| DISEASES 10755 \| GIPC1 \| DISEASES 80320 \| SP6 \| DISEASES 2804 \| GOLGB1 \| DISEASES 22953 \| P2RX2 \| DISEASES 155 \| ADRB3 \| DISEASES 53827 \| FXYD5 \| DISEASES 8654 \| PDE5A \| DISEASES 140885 \| SIRPA \| DISEASES 273 \| AMPH \| DISEASES 5733 \| PTGER3 \| DISEASES 157680 \| VPS13B \| DISEASES 9860 \| LRIG2 \| DISEASES 7432 \| VIP \| DISEASES 5996 \| RGS1 \| DISEASES 4803 \| NGF \| DISEASES 60495 \| HPSE2 \| DISEASES 6491 \| STIL \| DISEASES 6865 \| TACR2 \| DISEASES 84890 \| ADO \| DISEASES 6572 \| SLC18A3 \| DISEASES 8518 \| IKBKAP \| DISEASES 3055 \| HCK \| DISEASES 4340 \| MOG \| DISEASES 1471 \| CST3 \| DISEASES 551 \| AVP \| DISEASES 51109 \| RDH11 \| DISEASES 192668 \| CYS1 \| DISEASES 361 \| AQP4 \| DISEASES 57019 \| CIAPIN1 \| DISEASES 4828 \| NMB \| DISEASES 5744 \| PTHLH \| DISEASES 3652 \| IPP \| DISEASES 7442 \| TRPV1 \| DISEASES 2260 \| FGFR1 \| DISEASES 8671 \| SLC4A4 \| DISEASES 4908 \| NTF3 \| DISEASES 83876 \| MRO \| DISEASES 9498 \| SLC4A8 \| DISEASES 54900 \| LAX1 \| DISEASES 196527 \| ANO6 \| DISEASES 2632 \| GBE1 \| DISEASES 116 \| ADCYAP1 \| DISEASES 627 \| BDNF \| DISEASES 6229 \| RPS24 \| DISEASES 4359 \| MPZ \| DISEASES 5027 \| P2RX7 \| DISEASES 6510 \| SLC1A5 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1276
Disease	neurogenic bladder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:30) HP:0000010 \| Frequent urinary tract infections \| 9 HP:0002414 \| Spina bifida \| 5 HP:0000020 \| Bladder incontinence \| 4 HP:0000016 \| Urinary retention \| 3 HP:0002475 \| Myelomeningocele \| 3 HP:0000076 \| Vesicoureteric reflux \| 3 HP:0010301 \| Spinal dysraphism \| 2 HP:0007199 \| Progressive spastic paraparesis \| 2 HP:0000126 \| Hydronephrosis \| 2 HP:0002025 \| Narrowing of anal opening \| 1 HP:0100518 \| Painful or difficult urination \| 1 HP:0002196 \| Myelopathy \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0012461 \| Bacteria in urine \| 1 HP:0000072 \| Megaureter \| 1 HP:0030683 \| Vaginitis \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0000790 \| Hematuria \| 1 HP:0010480 \| Urethral fistula \| 1 HP:0002385 \| Paraparesis \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0002313 \| Spastic paraparesis \| 1 HP:0009725 \| Bladder neoplasm \| 1 HP:0003416 \| Spinal canal stenosis \| 1 HP:0005978 \| Noninsulin dependent diabetes mellitus \| 1 HP:0000047 \| Hypospadias \| 1 HP:0001941 \| acidemia \| 1 HP:0003468 \| Vertebral anomalies \| 1 HP:0012486 \| Inflammation of spinal cord \| 1

Disease ID	1276
Disease	neurogenic bladder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0009450 \| infection \| 6 C0042029 \| urinary tract infection \| 5 C0021167 \| incontinence \| 4 C0042024 \| urinary incontinence \| 4 C0042580 \| vesicoureteral reflux \| 3 C0042029 \| urinary tract infections \| 2 C0262655 \| recurrent urinary tract infections \| 1 C0004659 \| bacteriuria \| 1 C0149525 \| prostatic calculus \| 1 C1839611 \| n syndrome \| 1 C0238015 \| autonomic dysreflexia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0005697	baclofen	D001418	1134-47-0	urinary bladder, neurogenic	MESH:D001750	therapeutic	1442218
C0005697	bupivacaine	D002045	2180-92-9	urinary bladder, neurogenic	MESH:D001750	marker/mechanism	11685017
C0005697	methotrexate	D008727	1959/5/2	urinary bladder, neurogenic	MESH:D001750	marker/mechanism	17949753
C0005697	phenytoin	D010672	57-41-0	urinary bladder, neurogenic	MESH:D001750	marker/mechanism	2492459
C0005697	valproic acid	D014635	99-66-1	urinary bladder, neurogenic	MESH:D001750	marker/mechanism	2492459
C0005697	vincristine	D014750	-	urinary bladder, neurogenic	MESH:D001750	marker/mechanism	18176183

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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