PedAM

Pediatric Disease Annotations & Medicines


	neuritis

Disease ID	1359
Disease	neuritis
Definition	A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
Synonym	neuritides neuritides, peripheral neuritis (disorder) neuritis -retired- neuritis [disease/finding] neuritis peripheral neuritis unspecified neuritis unspecified (disorder) neuritis, nos neuritis, peripheral peripheral neuritides peripheral neuritis peripheral neuritis (disorder) peripheral neuritis, nos
DOID	DOID:1803
UMLS	C0027813
MeSH	D009443
SNOMED-CT	SNOMEDCT_US_2016_09_01:84299009;SNOMEDCT_US_2016_09_01:128192007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:98) C0026769 \| multiple sclerosis \| 34 C0027873 \| neuromyelitis optica \| 9 C0011303 \| demyelinating disease \| 6 C0456909 \| blindness \| 4 C0014070 \| encephalomyelitis \| 3 C0019158 \| hepatitis \| 3 C0023343 \| leprosy \| 3 C0392662 \| angiostrongyliasis \| 3 C0019360 \| zoster \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0019360 \| herpes zoster \| 3 C0021053 \| immune disease \| 2 C0034362 \| q fever \| 2 C0019163 \| hepatitis b \| 2 C0271051 \| macular edema \| 2 C0021400 \| influenza \| 2 C0029124 \| optic atrophy \| 2 C0028738 \| nystagmus \| 2 C0011303 \| demyelinating diseases \| 2 C0036454 \| visual field defect \| 2 C0019364 \| herpes zoster ophthalmicus \| 2 C0026975 \| myelitis \| 2 C0442874 \| neuropathy \| 2 C1527336 \| sjogren's syndrome \| 2 C0547030 \| visual disturbance \| 2 C0042164 \| uveitis \| 2 C0042384 \| vasculitis \| 1 C0004943 \| behcet's disease \| 1 C0007959 \| charcot-marie-tooth disease \| 1 C0002736 \| amyotrophic lateral sclerosis \| 1 C0524851 \| neurodegenerative diseases \| 1 C0013990 \| emphysema \| 1 C0003864 \| arthritis \| 1 C0038522 \| subacute sclerosing panencephalitis (sspe) \| 1 C0026764 \| myeloma \| 1 C0020450 \| hyperemesis gravidarum \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0015464 \| facial palsy \| 1 C0024419 \| macroglobulinemia \| 1 C0019360 \| herpes zoster infection \| 1 C0032285 \| pneumoniae \| 1 C0008049 \| chicken pox \| 1 C0028754 \| obesity \| 1 C0024419 \| waldenstrom macroglobulinemia \| 1 C0036472 \| scrub typhus \| 1 C0037928 \| myelopathy \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1 C0042721 \| viral hepatitis \| 1 C1692886 \| pyogenic arthritis \| 1 C0155502 \| benign paroxysmal positional vertigo \| 1 C0025297 \| viral meningitis \| 1 C0270911 \| charcot-marie-tooth disease type 1a \| 1 C1834580 \| ramsay hunt syndrome \| 1 C0004943 \| behcet's syndrome \| 1 C0008049 \| chickenpox \| 1 C0011303 \| demyelinating disorders \| 1 C0026896 \| myasthenia gravis \| 1 C0042373 \| vascular disorder \| 1 C0009782 \| connective tissue disorder \| 1 C0030353 \| papilloedema \| 1 C0456909 \| vision loss \| 1 C0023351 \| tuberculoid leprosy \| 1 C0040128 \| thyroid disease \| 1 C0007570 \| celiac disease \| 1 C0020514 \| hyperprolactinaemia \| 1 C0042165 \| anterior uveitis \| 1 C0024198 \| borrelia burgdorferi infection \| 1 C0010346 \| crohn disease \| 1 C0206178 \| cytomegalovirus retinitis \| 1 C0004134 \| ataxia \| 1 C0026764 \| multiple myeloma \| 1 C0014038 \| encephalitis \| 1 C0039128 \| syphilis \| 1 C0524851 \| neurodegenerative disease \| 1 C0042373 \| vascular disorders \| 1 C0598589 \| hereditary neuropathy \| 1 C0235660 \| galactorrhea \| 1 C0036454 \| visual field defects \| 1 C0220754 \| biotinidase deficiency \| 1 C0019364 \| zoster ophthalmicus \| 1 C0243010 \| viral encephalitis \| 1 C0035333 \| retinitis \| 1 C0033953 \| sexual dysfunction \| 1 C0025289 \| meningitis \| 1 C0547030 \| visual disturbances \| 1 C0005122 \| beriberi \| 1 C0043092 \| wegener's granulomatosis \| 1 C0409974 \| lupus erythematosus \| 1 C0041296 \| tuberculosis \| 1 C0235250 \| hyperemesis \| 1 C0042769 \| virus infection \| 1 C0334121 \| inflammatory pseudotumor \| 1 C0014544 \| epilepsy \| 1 C0010346 \| crohn's disease \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0015397 \| ocular disease \| 1 C0038358 \| gastric ulcer \| 1 C0025309 \| meningoencephalitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:148) 6376 \| CX3CL1 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 4804 \| NGFR \| DISEASES 9423 \| NTN1 \| DISEASES 1723 \| DHODH \| DISEASES 7040 \| TGFB1 \| DISEASES 5949 \| RBP3 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 3820 \| KLRB1 \| DISEASES 3565 \| IL4 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 84918 \| LRP11 \| DISEASES 23435 \| TARDBP \| DISEASES 10804 \| GJB6 \| DISEASES 27019 \| DNAI1 \| DISEASES 84329 \| HVCN1 \| DISEASES 9098 \| USP6 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 3630 \| INS \| DISEASES 348 \| APOE \| DISEASES 4298 \| MLLT1 \| DISEASES 2056 \| EPO \| DISEASES 314 \| AOC2 \| DISEASES 6737 \| TRIM21 \| DISEASES 123811 \| FOPNL \| DISEASES 5375 \| PMP2 \| DISEASES 53 \| ACP2 \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 109 \| ADCY3 \| DISEASES 6741 \| SSB \| DISEASES 9172 \| MYOM2 \| DISEASES 8731 \| RNMT \| DISEASES 3553 \| IL1B \| DISEASES 23095 \| KIF1B \| DISEASES 1371 \| CPOX \| DISEASES 3383 \| ICAM1 \| DISEASES 388 \| RHOB \| DISEASES 4851 \| NOTCH1 \| DISEASES 9638 \| FEZ1 \| DISEASES 3606 \| IL18 \| DISEASES 7292 \| TNFSF4 \| DISEASES 57105 \| CYSLTR2 \| DISEASES 351 \| APP \| DISEASES 56896 \| DPYSL5 \| DISEASES 6285 \| S100B \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 92304 \| SCGB3A1 \| DISEASES 6352 \| CCL5 \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 94234 \| FOXQ1 \| DISEASES 2020 \| EN2 \| DISEASES 4714 \| NDUFB8 \| DISEASES 94274 \| PPP1R14A \| DISEASES 1632 \| ECI1 \| DISEASES 3627 \| CXCL10 \| DISEASES 64446 \| DNAI2 \| DISEASES 344561 \| GPR148 \| DISEASES 5376 \| PMP22 \| DISEASES 8534 \| CHST1 \| DISEASES 4744 \| NEFH \| DISEASES 5551 \| PRF1 \| DISEASES 80381 \| CD276 \| DISEASES 491 \| ATP2B2 \| DISEASES 9033 \| PKD2L1 \| DISEASES 55748 \| CNDP2 \| DISEASES 2187 \| FANCB \| DISEASES 1668 \| DEFA3 \| DISEASES 83733 \| SLC25A18 \| DISEASES 64782 \| AEN \| DISEASES 942 \| CD86 \| DISEASES 90249 \| UNC5A \| DISEASES 5133 \| PDCD1 \| DISEASES 342035 \| GLDN \| DISEASES 5025 \| P2RX4 \| DISEASES 3363 \| HTR7 \| DISEASES 6622 \| SNCA \| DISEASES 59277 \| NTN4 \| DISEASES 921 \| CD5 \| DISEASES 3605 \| IL17A \| DISEASES 23114 \| NFASC \| DISEASES 9600 \| PITPNM1 \| DISEASES 3177 \| SLC29A2 \| DISEASES 1524 \| CX3CR1 \| DISEASES 4133 \| MAP2 \| DISEASES 54106 \| TLR9 \| DISEASES 9846 \| GAB2 \| DISEASES 4538 \| MT-ND4 \| DISEASES 5743 \| PTGS2 \| DISEASES 962 \| CD48 \| DISEASES 115352 \| FCRL3 \| DISEASES 914 \| CD2 \| DISEASES 4803 \| NGF \| DISEASES 282991 \| BLOC1S2 \| DISEASES 2334 \| AFF2 \| DISEASES 959 \| CD40LG \| DISEASES 680 \| BRS3 \| DISEASES 958 \| CD40 \| DISEASES 4318 \| MMP9 \| DISEASES 9469 \| CHST3 \| DISEASES 10800 \| CYSLTR1 \| DISEASES 6191 \| RPS4X \| DISEASES 2833 \| CXCR3 \| DISEASES 1896 \| EDA \| DISEASES 3339 \| HSPG2 \| DISEASES 54829 \| ASPN \| DISEASES 6392 \| SDHD \| DISEASES 199 \| AIF1 \| DISEASES 50943 \| FOXP3 \| DISEASES 1041 \| CDSN \| DISEASES 7454 \| WAS \| DISEASES 4340 \| MOG \| DISEASES 9445 \| ITM2B \| DISEASES 4897 \| NRCAM \| DISEASES 646480 \| FABP9 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 22866 \| CNKSR2 \| DISEASES 3456 \| IFNB1 \| DISEASES 3662 \| IRF4 \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 4099 \| MAG \| DISEASES 9244 \| CRLF1 \| DISEASES 2596 \| GAP43 \| DISEASES 374654 \| KIF7 \| DISEASES 64400 \| AKTIP \| DISEASES 6164 \| RPL34 \| DISEASES 9255 \| AIMP1 \| DISEASES 4905 \| NSF \| DISEASES 25983 \| NGDN \| DISEASES 7124 \| TNF \| DISEASES 4049 \| LTA \| DISEASES 4152 \| MBD1 \| DISEASES 388372 \| CCL4L1 \| DISEASES 81704 \| DOCK8 \| DISEASES 2668 \| GDNF \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 4359 \| MPZ \| DISEASES 54970 \| TTC12 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1359
Disease	neuritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:57) HP:0000572 \| Visual loss \| 8 HP:0011096 \| Demyelination \| 5 HP:0000618 \| Blindness \| 4 HP:0040078 \| Axonal degeneration \| 3 HP:0001945 \| Fever \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0000639 \| Nystagmus \| 2 HP:0012531 \| Pain \| 2 HP:0012486 \| Inflammation of spinal cord \| 2 HP:0040049 \| Macular edema \| 2 HP:0002321 \| Vertigo \| 2 HP:0100829 \| Galactorrhoea \| 2 HP:0000505 \| Poor vision \| 2 HP:0002180 \| Neurodegeneration \| 2 HP:0000648 \| Optic-nerve degeneration \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0001123 \| Partial loss of field of vision \| 2 HP:0000554 \| Uveitis \| 2 HP:0030528 \| Paracentral scotoma \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0001287 \| Meningitis \| 1 HP:0005318 \| Cerebral vasculitis \| 1 HP:0001251 \| Ataxia \| 1 HP:0005508 \| Waldenstrom macroglobulinemia \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0002664 \| Neoplasia \| 1 HP:0000016 \| Urinary retention \| 1 HP:0002383 \| Encephalitis \| 1 HP:0001513 \| Obesity \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0000870 \| Hyperprolactinemia \| 1 HP:0000820 \| Thyroid abnormality \| 1 HP:0007354 \| Amyotrophic lateral sclerosis \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0000529 \| Slowly progressive visual loss \| 1 HP:0003447 \| Axonal loss \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0100561 \| Spinal cord lesion \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0007663 \| Central visual loss \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0002592 \| Stomach ulcer \| 1 HP:0001369 \| Arthritis \| 1 HP:0001171 \| Hand ectrodactyly \| 1 HP:0002608 \| Celiac disease \| 1 HP:0012188 \| Hyperemesis gravidarum \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0002196 \| Myelopathy \| 1 HP:0002883 \| Rapid breathing \| 1 HP:0000969 \| Dropsy \| 1 HP:0100246 \| Osteoma \| 1 HP:0002633 \| Vasculitis \| 1 HP:0000603 \| Central scotomata \| 1

Disease ID	1359
Disease	neuritis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0030193 \| pain \| 2 C0030353 \| papilloedema \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:9)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0027813	fluorouracil	D005472	51-21-8	neuritis	MESH:D009443	marker/mechanism	17430663
C0027813	leucovorin	D002955	1958/5/9	neuritis	MESH:D009443	marker/mechanism	17430663
C0027813	foscarnet	D017245	4428-95-9	neuritis	MESH:D009443	marker/mechanism	9761526
C0027813	lidocaine	D008012	137-58-6	neuritis	MESH:D009443	marker/mechanism	19224819
C0027813	oxaliplatin	C030110	-	neuritis	MESH:D009443	marker/mechanism	17430663
C0027813	paclitaxel	D017239	-	neuritis	MESH:D009443	marker/mechanism	8893892
C0027813	thalidomide	D013792	50-35-1	neuritis	MESH:D009443	marker/mechanism	7579470
C0027813	vinblastine	D014747	865-21-4	neuritis	MESH:D009443	marker/mechanism	5768441
C0027813	vinorelbine	C030852	71486-22-1	neuritis	MESH:D009443	marker/mechanism	18819904

FDA approved drug and dosage information(Total Drugs:3)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D009443	eloxatin	oxaliplatin	50MG/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	INJECTABLE;IV (INFUSION)	Discontinued	None	Yes	No
MESH:D009443	eloxatin	oxaliplatin	50MG/10ML (5MG/ML)	INJECTABLE;IV (INFUSION)	Prescription	AP	Yes	Yes
MESH:D009443	oxaliplatin	oxaliplatin	50MG/10ML (5MG/ML)	INJECTABLE;IV (INFUSION)	Prescription	AP	Yes	Yes

FDA labeling changes(Total Drugs:3)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D009443	10/1/2007	eloxatin	oxaliplatin	Solid tumors	The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs	Labeling	B	-	-	-	Sanofi-Aventis	09/27/2006	FALSE'
MESH:D009443	10/1/2007	eloxatin	oxaliplatin	Solid tumors	The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs	Labeling	B	-	-	-	Sanofi-Aventis	09/27/2006	FALSE'
MESH:D009443	10/1/2007	eloxatin	oxaliplatin	Solid tumors	The effectiveness of oxaliplatin in children has not been established No significant activity observed in 2 Phase I and 2 Phase II trials in 159 patients ages 7 months to 22 years with solid tumors Information on clinical studies and AEs	Labeling	B	-	-	-	Sanofi-Aventis	09/27/2006	FALSE'

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