nervous system disease |
Disease ID | 1070 |
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Disease | nervous system disease |
Integrated Phenotype | (Waiting for update.) |
Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:22) HP:0002665 | Lymphoma | 2 HP:0000127 | Salt wasting | 1 HP:0012531 | Pain | 1 HP:0100033 | Tic disorder | 1 HP:0004395 | Malnutrition | 1 HP:0004325 | Low body weight | 1 HP:0003006 | Neuroblastoma | 1 HP:0000716 | Depression | 1 HP:0002180 | Neurodegeneration | 1 HP:0100595 | Camptocormia | 1 HP:0001337 | Tremor | 1 HP:0002615 | Low blood pressure | 1 HP:0001278 | Orthostatic hypotension | 1 HP:0004808 | Acute myelogenous leukemia | 1 HP:0100614 | Muscle inflammation | 1 HP:0011096 | Demyelination | 1 HP:0002721 | Immunodeficiency | 1 HP:0012683 | Pineal cyst | 1 HP:0004326 | Cachexia | 1 HP:0000739 | Anxiety | 1 HP:0005523 | Lymphoproliferative disorder | 1 HP:0001250 | Seizures | 1 |
Disease ID | 1070 |
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Disease | nervous system disease |
Manually Symptom | (Waiting for update.) |
Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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(Waiting for update.) |
All Snps(Total Genotypes:6) | |||||||||||||
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snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
rs1064039 | 20849835 | 1471 | CST3 | umls:C0027765 | BeFree | Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3. | 0.002638474 | 2010 | CST3 | 20 | 23637790 | C | T |
rs121913223 | 21310277 | 1719 | DHFR | umls:C0027765 | BeFree | In conclusion, the homozygous DHFR mutation p.Asp153Val causes DHFR deficiency and leads to a complex hematological and neurological disease that can be successfully treated with folinic acid. | 0.120271442 | 2011 | DHFR | 5 | 80633904 | T | A |
rs28934908 | 11805248 | 4204 | MECP2 | umls:C0027765 | BeFree | The neurologic disorder associated with A140V MECP2 mutation is not necessarily lethal in men, but they are more severely affected than women of the same family. | 0.014048964 | 2002 | MECP2 | X | 154031409 | G | T,A |
rs35753505 | 25106628 | 3084 | NRG1 | umls:C0027765 | BeFree | Drugs targeting SNPrs35753505 of the NRG1 gene may prevent the association of neurological disorder schizophrenia in a Pakistani population. | 0.000271442 | 2014 | NA | 8 | 31616625 | T | C |
rs4680 | 25929431 | 1312 | COMT | umls:C0027765 | BeFree | Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms was performed on 380 unrelated migraine patients, and 132 healthy subjects matched for age, gender and race-ethnicity, with no clinical evidence or family history of migraine or other neurological diseases. | 0.001357209 | 2015 | COMT;MIR4761 | 22 | 19963748 | G | A |
rs4818 | 25929431 | 1312 | COMT | umls:C0027765 | BeFree | Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms was performed on 380 unrelated migraine patients, and 132 healthy subjects matched for age, gender and race-ethnicity, with no clinical evidence or family history of migraine or other neurological diseases. | 0.001357209 | 2015 | COMT;MIR4761 | 22 | 19963684 | C | G,T |
GWASdb Annotation(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Snp Trait(Total Genotypes:0) | |
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(Waiting for update.) |
Mapped by lexical matching(Total Items:0) |
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(Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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(Waiting for update.) |
Chemical(Total Drugs:87) | |||||||||
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CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
C0027765 | alpha-linolenic acid | D017962 | 463-40-1 | nervous system diseases | MESH:D009422 | therapeutic | 22884490 | ||
C0027765 | altretamine | D006585 | 645-05-6 | nervous system diseases | MESH:D009422 | marker/mechanism | 113095 | ||
C0027765 | amikacin | D000583 | 37517-28-5 | nervous system diseases | MESH:D009422 | marker/mechanism | 868909 | ||
C0027765 | amitriptyline | D000639 | 50-48-6 | nervous system diseases | MESH:D009422 | marker/mechanism | 15372388 | ||
C0027765 | amodiaquine | D000655 | 86-42-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 14717048 | ||
C0027765 | amphetamine | D000661 | 300-62-9 | nervous system diseases | MESH:D009422 | marker/mechanism | 10788568 | ||
C0027765 | ampicillin | D000667 | 69-53-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 9562146 | ||
C0027765 | arsenic trioxide | C006632 | 1327-53-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 11864496 | ||
C0027765 | atropine | D001285 | 51-55-8 | nervous system diseases | MESH:D009422 | therapeutic | 22796677 | ||
C0027765 | bleomycin | D001761 | 11056-06-7 | nervous system diseases | MESH:D009422 | marker/mechanism | 7534090 | ||
C0027765 | bortezomib | D000069286 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 17214983 | ||
C0027765 | bupivacaine | D002045 | 2180-92-9 | nervous system diseases | MESH:D009422 | marker/mechanism | 17277955 | ||
C0027765 | capsaicin | D002211 | 404-86-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 6847703 | ||
C0027765 | carbamazepine | D002220 | 298-46-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 1352629 | ||
C0027765 | carmustine | D002330 | 154-93-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 10918425 | ||
C0027765 | ceftazidime | D002442 | 78439-06-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 12627936 | ||
C0027765 | celecoxib | D000068579 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 17084549 | ||
C0027765 | chloramphenicol | D002701 | 56-75-7 | nervous system diseases | MESH:D009422 | marker/mechanism | 1158315 | ||
C0027765 | chloroquine | D002738 | 1954/5/7 | nervous system diseases | MESH:D009422 | marker/mechanism | 12493616 | ||
C0027765 | chlorpromazine | D002746 | 50-53-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 7254089 | ||
C0027765 | cimetidine | D002927 | 51481-61-9 | nervous system diseases | MESH:D009422 | marker/mechanism | 6104247 | ||
C0027765 | ciprofloxacin | D002939 | 85721-33-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11344971 | ||
C0027765 | clozapine | D003024 | 5786-21-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 10831017 | ||
C0027765 | clozapine | D003024 | 5786-21-0 | nervous system diseases | MESH:D009422 | therapeutic | 11927170 | ||
C0027765 | colchicine | D003078 | 64-86-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 2046950 | ||
C0027765 | cyclophosphamide | D003520 | 50-18-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 19274460 | ||
C0027765 | cyclosporine | D016572 | 59865-13-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 1818543 | ||
C0027765 | dapsone | D003622 | 80-08-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 7464425 | ||
C0027765 | cisplatin | D002945 | 15663-27-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11205470 | ||
C0027765 | diclofenac | D004008 | 15307-86-5 | nervous system diseases | MESH:D009422 | marker/mechanism | 8510483 | ||
C0027765 | diltiazem | D004110 | 42399-41-7 | nervous system diseases | MESH:D009422 | marker/mechanism | 3569036 | ||
C0027765 | doxycycline | D004318 | 564-25-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 8902563 | ||
C0027765 | droperidol | D004329 | 548-73-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 6370028 | ||
C0027765 | epirubicin | D015251 | 56420-45-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 18042835 | ||
C0027765 | ethambutol | D004977 | 74-55-5 | nervous system diseases | MESH:D009422 | marker/mechanism | 4345372 | ||
C0027765 | fenfluramine | D005277 | 458-24-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 12969273 | ||
C0027765 | fluorouracil | D005472 | 51-21-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 10099659 | ||
C0027765 | flutamide | D005485 | 13311-84-7 | nervous system diseases | MESH:D009422 | therapeutic | 15715105 | ||
C0027765 | folic acid | D005492 | 59-30-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 5343988 | ||
C0027765 | leucovorin | D002955 | 1958/5/9 | nervous system diseases | MESH:D009422 | therapeutic | 19736586 | ||
C0027765 | gemcitabine | C056507 | 103882-84-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 9164208 | ||
C0027765 | glutathione | D005978 | 70-18-8 | nervous system diseases | MESH:D009422 | therapeutic | 19287306 | ||
C0027765 | haloperidol | D006220 | 52-86-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 1134541 | ||
C0027765 | haloperidol | D006220 | 52-86-8 | nervous system diseases | MESH:D009422 | therapeutic | 11927170 | ||
C0027765 | hydroxyurea | D006918 | 127-07-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11061656 | ||
C0027765 | ifosfamide | D007069 | 3778-73-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 18719071 | ||
C0027765 | lamotrigine | C047781 | 84057-84-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 12821749 | ||
C0027765 | lansoprazole | D064747 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 15468341 | ||
C0027765 | lidocaine | D008012 | 137-58-6 | nervous system diseases | MESH:D009422 | marker/mechanism | 10994828 | ||
C0027765 | lidocaine | D008012 | 137-58-6 | nervous system diseases | MESH:D009422 | therapeutic | 17277955 | ||
C0027765 | lindane | D001556 | 58-89-9 | nervous system diseases | MESH:D009422 | marker/mechanism | 2459503 | ||
C0027765 | loxapine | D008152 | 1977/10/2 | nervous system diseases | MESH:D009422 | marker/mechanism | 2715145 | ||
C0027765 | mefloquine | D015767 | 53230-10-7 | nervous system diseases | MESH:D009422 | marker/mechanism | 12242605 | ||
C0027765 | melphalan | D008558 | 148-82-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 7802575 | ||
C0027765 | mesna | D015080 | 19767-45-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 18719071 | ||
C0027765 | dextromethorphan | D003915 | 125-71-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 16122622 | ||
C0027765 | dextromethorphan | D003915 | 125-71-3 | nervous system diseases | MESH:D009422 | therapeutic | 12078863 | ||
C0027765 | methotrexate | D008727 | 1959/5/2 | nervous system diseases | MESH:D009422 | marker/mechanism | 10963643 | ||
C0027765 | mitomycin | D016685 | 1950/7/7 | nervous system diseases | MESH:D009422 | marker/mechanism | 1260786 | ||
C0027765 | morphine | D009020 | 57-27-2 | nervous system diseases | MESH:D009422 | marker/mechanism | 12196588 | ||
C0027765 | nelarabine | C104457 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 20528871 | ||
C0027765 | nicotine | D009538 | - | nervous system diseases | MESH:D009422 | therapeutic | 9832142 | ||
C0027765 | olanzapine | C076029 | 132539-06-1 | nervous system diseases | MESH:D009422 | therapeutic | 11927170 | ||
C0027765 | oxaliplatin | C030110 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 19287306 | ||
C0027765 | paclitaxel | D017239 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 10362115 | ||
C0027765 | pegfilgrastim | C455861 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 20547415 | ||
C0027765 | phenytoin | D010672 | 57-41-0 | nervous system diseases | MESH:D009422 | marker/mechanism | 10192272 | ||
C0027765 | picrotoxin | D010852 | 124-87-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 17074045 | ||
C0027765 | progesterone | D011374 | 57-83-0 | nervous system diseases | MESH:D009422 | therapeutic | 11129103 | ||
C0027765 | pyridoxine | D011736 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 6457438 | ||
C0027765 | pyridoxine | D011736 | - | nervous system diseases | MESH:D009422 | therapeutic | 7283299 | ||
C0027765 | rifampin | D012293 | 13292-46-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 1573293 | ||
C0027765 | ritonavir | D019438 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 20736152 | ||
C0027765 | streptozocin | D013311 | 18883-66-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 19840221 | ||
C0027765 | tacrolimus | D016559 | 109581-93-3 | nervous system diseases | MESH:D009422 | marker/mechanism | 11100278 | ||
C0027765 | temozolomide | C047246 | 85622-93-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 20684359 | ||
C0027765 | thalidomide | D013792 | 50-35-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11090092 | ||
C0027765 | theophylline | D013806 | 58-55-9 | nervous system diseases | MESH:D009422 | marker/mechanism | 2038423 | ||
C0027765 | thiotepa | D013852 | 52-24-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 10918425 | ||
C0027765 | tinidazole | D014011 | 19387-91-8 | nervous system diseases | MESH:D009422 | marker/mechanism | 2091179 | ||
C0027765 | valproic acid | D014635 | 99-66-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11737171 | ||
C0027765 | vincristine | D014750 | - | nervous system diseases | MESH:D009422 | marker/mechanism | 12552058 | ||
C0027765 | vindesine | D014751 | 53643-48-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 17617780 | ||
C0027765 | vinorelbine | C030852 | 71486-22-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 11745280 | ||
C0027765 | vitamin e | D014810 | 1406-18-4 | nervous system diseases | MESH:D009422 | marker/mechanism | 15753152 | ||
C0027765 | vitamin e | D014810 | 1406-18-4 | nervous system diseases | MESH:D009422 | therapeutic | 15300460 | ||
C0027765 | zidovudine | D015215 | 30516-87-1 | nervous system diseases | MESH:D009422 | marker/mechanism | 7534090 |
FDA approved drug and dosage information(Total Drugs:0) | |
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(Waiting for update.) |
FDA labeling changes(Total Drugs:0) | |
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(Waiting for update.) |