PedAM

Pediatric Disease Annotations & Medicines


	nephrotic syndrome

Disease ID	185
Disease	nephrotic syndrome
Definition	A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Synonym	#NAME? nephrotic syndrome (disorder) nephrotic syndrome [disease/finding] nephrotic syndrome nos nephrotic syndrome nos (disorder) nephrotic syndrome, nos nephrotic syndromes ns - nephrotic syndrome syndrome nephrotic syndrome, nephrotic syndromes, nephrotic
DOID	DOID:1184
UMLS	C0027726
MeSH	D009404
SNOMED-CT	SNOMEDCT_US_2016_09_01:52254009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:196) C0033687 \| proteinuria \| 54 C0022658 \| nephropathy \| 36 C0017665 \| membranous nephropathy \| 21 C0035078 \| renal failure \| 16 C0040053 \| thrombosis \| 15 C0017658 \| glomerulonephritis \| 15 C0178664 \| glomerulosclerosis \| 15 C0017668 \| focal segmental glomerulosclerosis \| 11 C0002726 \| amyloidosis \| 10 C0017661 \| iga nephropathy \| 9 C0027697 \| nephritis \| 9 C0022658 \| kidney disease \| 8 C0398623 \| hypercoagulable state \| 6 C0020676 \| hypothyroidism \| 5 C0033838 \| kimura's disease \| 5 C0022660 \| acute renal failure \| 5 C0007785 \| cerebral infarction \| 4 C0024143 \| lupus nephritis \| 4 C0011881 \| diabetic nephropathy \| 4 C0031154 \| peritonitis \| 4 C0149985 \| secondary syphilis \| 4 C0039128 \| syphilis \| 4 C0007785 \| cerebral infarct \| 4 C0022658 \| renal disease \| 4 C0024141 \| systemic lupus erythematosus \| 3 C0238198 \| gastrointestinal stromal tumor \| 3 C0019163 \| hepatitis b \| 3 C1565489 \| renal insufficiency \| 3 C0022679 \| cystic kidney \| 3 C0034150 \| purpura \| 3 C0024299 \| lymphoma \| 3 C0019158 \| hepatitis \| 3 C0085413 \| autosomal dominant polycystic kidney \| 3 C0004153 \| atherosclerosis \| 3 C0879615 \| stromal tumor \| 3 C0398623 \| hypercoagulability \| 3 C0085413 \| autosomal dominant polycystic kidney disease \| 3 C0034065 \| pulmonary embolism \| 3 C0017665 \| membranous glomerulonephritis \| 2 C0021831 \| bowel disease \| 2 C0040100 \| thymoma \| 2 C0018801 \| heart failure \| 2 C0009324 \| ulcerative colitis \| 2 C0235618 \| proliferative glomerulonephritis \| 2 C0022661 \| chronic renal failure \| 2 C0035078 \| kidney failure \| 2 C0022661 \| end-stage renal disease \| 2 C0022661 \| chronic kidney disease \| 2 C0032285 \| pneumonia \| 2 C0026691 \| kawasaki disease \| 2 C0010414 \| cryptococcosis \| 2 C0031069 \| familial mediterranean fever \| 2 C0019196 \| hepatitis c \| 2 C0025958 \| microcephaly \| 2 C0020757 \| ichthyosis \| 2 C0020443 \| hypercholesterolemia \| 2 C0409974 \| lupus erythematosus \| 2 C0020538 \| hypertension \| 2 C0010346 \| crohn's disease \| 2 C0037198 \| sinus thrombosis \| 2 C0029456 \| osteoporosis \| 2 C0023281 \| leishmaniasis \| 1 C0027051 \| myocardial infarct \| 1 C0007134 \| renal cell carcinoma \| 1 C0040053 \| thrombus \| 1 C0013502 \| hydatid cyst \| 1 C0020538 \| vascular hypertension \| 1 C0220647 \| carcinoma of unknown primary \| 1 C0007177 \| pericardial tamponade \| 1 C0015190 \| euthyroid sick syndrome \| 1 C0152025 \| polyneuropathy \| 1 C0302592 \| carcinoma of the cervix \| 1 C0376545 \| hematological malignancies \| 1 C0040147 \| thyroiditis \| 1 C0023234 \| perthes disease \| 1 C0024530 \| malaria \| 1 C0021933 \| intussusception \| 1 C0006267 \| bronchiectasis \| 1 C0302592 \| cervical ca \| 1 C0011991 \| diarrhoea \| 1 C0018802 \| congestive heart failure \| 1 C0018378 \| guillain-barre syndrome \| 1 C0023195 \| lcat deficiency \| 1 C0345967 \| malignant mesothelioma \| 1 C0002871 \| anemia \| 1 C0030328 \| weber-christian disease \| 1 C0032461 \| polycythaemia \| 1 C0028242 \| nocardiosis \| 1 C0021390 \| inflammatory bowel disease \| 1 C0042769 \| virus infection \| 1 C0280131 \| ovarian teratoma \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0152013 \| lung adenocarcinoma \| 1 C0019829 \| hodgkin lymphoma \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0027708 \| wilms' tumor \| 1 C0004623 \| bacterial infection \| 1 C0278846 \| invasive thymoma \| 1 C0152018 \| esophageal carcinoma \| 1 C0017665 \| membranous glomerulopathy \| 1 C0039730 \| thalassemia \| 1 C0036319 \| schistosoma mansoni \| 1 C0001418 \| adenocarcinoma \| 1 C2717836 \| steroid sulfatase deficiency \| 1 C0687720 \| central diabetes insipidus \| 1 C0001126 \| renal tubular acidosis \| 1 C0015519 \| factor x deficiency \| 1 C0340305 \| inferior myocardial infarction \| 1 C0036472 \| tsutsugamushi \| 1 C0027819 \| neuroblastoma \| 1 C0010068 \| coronary heart disease \| 1 C1527336 \| sjogren's syndrome \| 1 C0024419 \| macroglobulinaemia \| 1 C0302592 \| cervical carcinoma \| 1 C1527411 \| retinal vein thrombosis \| 1 C0011884 \| diabetic retinopathy \| 1 C0001363 \| acute mesenteric ischemia \| 1 C0018799 \| heart disease \| 1 C0018051 \| gonadal dysgenesis \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0033838 \| kimura disease \| 1 C0007785 \| cerebral infarctions \| 1 C0035309 \| retinopathy \| 1 C0878544 \| cardiomyopathy \| 1 C0024236 \| lymphedema \| 1 C0684249 \| lung carcinoma \| 1 C0079774 \| peripheral t cell lymphoma \| 1 C0524988 \| schnitzler syndrome \| 1 C0032305 \| pneumocystis jiroveci pneumonia \| 1 C0022672 \| acute tubular necrosis \| 1 C0036472 \| tsutsugamushi disease \| 1 C0085655 \| polymyositis \| 1 C0151650 \| renal fibrosis \| 1 C0001621 \| adrenal disorders \| 1 C0346109 \| peritoneal mesothelioma \| 1 C0026946 \| mycosis \| 1 C0023484 \| plasma cell leukaemia \| 1 C0024419 \| waldenstrom's macroglobulinaemia \| 1 C0004623 \| bacterial infections \| 1 C0011847 \| diabetes \| 1 C0018802 \| congestive cardiac failure \| 1 C0015974 \| periodic fever \| 1 C0812413 \| malignant pleural mesothelioma \| 1 C0002895 \| sickle cell disease \| 1 C0014859 \| esophageal cancer \| 1 C0021053 \| immune disease \| 1 C0027708 \| wilms' tumour \| 1 C0001623 \| adrenal insufficiency \| 1 C0268713 \| congenital nephrotic syndrome \| 1 C0008354 \| vibrio cholerae \| 1 C0376545 \| hematological malignancy \| 1 C0001824 \| agranulocytosis \| 1 C0205969 \| malignant thymoma \| 1 C0268450 \| gitelman's syndrome \| 1 C0011615 \| atopic dermatitis \| 1 C0022661 \| end stage renal disease \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0178664 \| glomerular sclerosis \| 1 C0011848 \| diabetes insipidus \| 1 C0341950 \| severe pre-eclampsia \| 1 C0004096 \| asthma \| 1 C0023487 \| acute promyelocytic leukemia \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C0001175 \| acquired immunodeficiency syndrome \| 1 C0022658 \| renal disorders \| 1 C0041296 \| tuberculosis \| 1 C0008728 \| churg-strauss syndrome \| 1 C1377913 \| pleural mesothelioma \| 1 C0011860 \| type 2 diabetes \| 1 C0027051 \| myocardial infarction \| 1 C0017574 \| gingivitis \| 1 C0155550 \| neural deafness \| 1 C0022661 \| end-stage renal failure \| 1 C0041471 \| typhus \| 1 C0278678 \| metastatic renal cell carcinoma \| 1 C0020545 \| renovascular hypertension \| 1 C0079588 \| x-linked recessive ichthyosis \| 1 C0740394 \| hyperuricemia \| 1 C0242379 \| lung cancer \| 1 C0038013 \| ankylosing spondylitis \| 1 C0032587 \| polyradiculoneuropathy \| 1 C0268407 \| cardiac amyloidosis \| 1 C0036202 \| sarcoidosis \| 1 C0079584 \| ichthyosis vulgaris \| 1 C0018784 \| sensorineural deafness \| 1 C0007642 \| cellulitis \| 1 C0242647 \| malt lymphoma \| 1 C0017658 \| glomerulonephritides \| 1 C0026147 \| primary lymphedema \| 1 C0041956 \| ureteric obstruction \| 1 C0038012 \| spondylitis \| 1 C0026769 \| multiple sclerosis \| 1 C0018801 \| cardiac failure \| 1 C0007194 \| hypertrophic cardiomyopathy \| 1 C0036472 \| scrub typhus \| 1 C0699791 \| gastric carcinoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:21) HLA-DRB1 \| 3123 \| CTD_human SOD2 \| 6648 \| CTD_human TGFB1 \| 7040 \| CTD_human COL4A1 \| 1282 \| CTD_human COL1A1 \| 1277 \| CTD_human NPHS2 \| 7827 \| CTD_human GUCA2B \| 2981 \| CTD_human ALB \| 213 \| CTD_human IL2 \| 3558 \| CTD_human SERPINE1 \| 5054 \| CTD_human HSD11B2 \| 3291 \| CTD_human SERPINC1 \| 462 \| CTD_human TF \| 7018 \| CTD_human GPC5 \| 2262 \| CTD_human;GWASCAT F3 \| 2152 \| CTD_human A2M \| 2 \| CTD_human FGF2 \| 2247 \| CTD_human CD2 \| 914 \| CTD_human COL4A2 \| 1284 \| CTD_human NCK2 \| 8440 \| CTD_human NCK1 \| 4690 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:27) 5243 \| ABCB1 \| infer 1636 \| ACE \| infer 348 \| APOE \| infer 2207 \| FCER1G \| infer 2262 \| GPC5 \| infer 2944 \| GSTM1 \| infer 2950 \| GSTP1 \| infer 2952 \| GSTT1 \| infer 3105 \| HLA-A \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3596 \| IL13 \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer 3569 \| IL6 \| infer 3913 \| LAMB2 \| infer 4282 \| MIF \| infer 4868 \| NPHS1 \| infer 7827 \| NPHS2 \| infer 2908 \| NR3C1 \| infer 170552 \| SRMP1 \| infer 6778 \| STAT6 \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer 7490 \| WT1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:347) 3675 \| ITGA3 \| DISEASES 5536 \| PPP5C \| DISEASES 608 \| TNFRSF17 \| DISEASES 340533 \| KIAA2022 \| DISEASES 3566 \| IL4R \| DISEASES 359 \| AQP2 \| DISEASES 1071 \| CETP \| DISEASES 3053 \| SERPIND1 \| DISEASES 4282 \| MIF \| DISEASES 57026 \| PDXP \| DISEASES 4627 \| MYH9 \| DISEASES 412 \| STS \| DISEASES 2158 \| F9 \| DISEASES 4210 \| MEFV \| DISEASES 8797 \| TNFRSF10A \| DISEASES 2217 \| FCGRT \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 5444 \| PON1 \| DISEASES 8976 \| WASL \| DISEASES 5054 \| SERPINE1 \| DISEASES 113263 \| GLCCI1 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 345 \| APOC3 \| DISEASES 3458 \| IFNG \| DISEASES 57122 \| NUP107 \| DISEASES 2597 \| GAPDH \| DISEASES 55907 \| CMAS \| DISEASES 3565 \| IL4 \| DISEASES 2908 \| NR3C1 \| DISEASES 3273 \| HRG \| DISEASES 7035 \| TFPI \| DISEASES 338 \| APOB \| DISEASES 3485 \| IGFBP2 \| DISEASES 5657 \| PRTN3 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 5311 \| PKD2 \| DISEASES 29094 \| LGALSL \| DISEASES 718 \| C3 \| DISEASES 10047 \| CST8 \| DISEASES 5199 \| CFP \| DISEASES 821 \| CANX \| DISEASES 391013 \| PLA2G2C \| DISEASES 3315 \| HSPB1 \| DISEASES 968 \| CD68 \| DISEASES 3630 \| INS \| DISEASES 80714 \| PBX4 \| DISEASES 5894 \| RAF1 \| DISEASES 348 \| APOE \| DISEASES 81 \| ACTN4 \| DISEASES 2056 \| EPO \| DISEASES 3911 \| LAMA5 \| DISEASES 10343 \| PKDREJ \| DISEASES 2161 \| F12 \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 6341 \| SCO1 \| DISEASES 4608 \| MYBPH \| DISEASES 271 \| AMPD2 \| DISEASES 81494 \| CFHR5 \| DISEASES 4677 \| NARS \| DISEASES 2799 \| GNS \| DISEASES 5279 \| PIGC \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 27179 \| IL36A \| DISEASES 27283 \| TINAG \| DISEASES 51196 \| PLCE1 \| DISEASES 9360 \| PPIG \| DISEASES 4069 \| LYZ \| DISEASES 29121 \| CLEC2D \| DISEASES 55746 \| NUP133 \| DISEASES 7450 \| VWF \| DISEASES 57534 \| MIB1 \| DISEASES 949 \| SCARB1 \| DISEASES 9172 \| MYOM2 \| DISEASES 56052 \| ALG1 \| DISEASES 57017 \| COQ9 \| DISEASES 25939 \| SAMHD1 \| DISEASES 1 \| A1BG \| DISEASES 23523 \| CABIN1 \| DISEASES 3553 \| IL1B \| DISEASES 6403 \| SELP \| DISEASES 4036 \| LRP2 \| DISEASES 3931 \| LCAT \| DISEASES 941 \| CD80 \| DISEASES 8916 \| HERC3 \| DISEASES 23530 \| NNT \| DISEASES 3818 \| KLKB1 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 306 \| ANXA3 \| DISEASES 6550 \| SLC9A3 \| DISEASES 3827 \| KNG1 \| DISEASES 259 \| AMBP \| DISEASES 56302 \| TRPV5 \| DISEASES 5243 \| ABCB1 \| DISEASES 6595 \| SMARCA2 \| DISEASES 3263 \| HPX \| DISEASES 1583 \| CYP11A1 \| DISEASES 8128 \| ST8SIA2 \| DISEASES 8826 \| IQGAP1 \| DISEASES 6687 \| SPG7 \| DISEASES 396 \| ARHGDIA \| DISEASES 5972 \| REN \| DISEASES 185 \| AGTR1 \| DISEASES 10699 \| CORIN \| DISEASES 10788 \| IQGAP2 \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 2206 \| MS4A2 \| DISEASES 3606 \| IL18 \| DISEASES 5800 \| PTPRO \| DISEASES 7082 \| TJP1 \| DISEASES 5741 \| PTH \| DISEASES 22925 \| PLA2R1 \| DISEASES 55079 \| FEZF2 \| DISEASES 8526 \| DGKE \| DISEASES 23165 \| NUP205 \| DISEASES 2040 \| STOM \| DISEASES 3156 \| HMGCR \| DISEASES 4643 \| MYO1E \| DISEASES 4690 \| NCK1 \| DISEASES 1636 \| ACE \| DISEASES 56894 \| AGPAT3 \| DISEASES 3046 \| HBE1 \| DISEASES 6352 \| CCL5 \| DISEASES 58191 \| CXCL16 \| DISEASES 2215 \| FCGR3B \| DISEASES 4880 \| NPPC \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 7098 \| TLR3 \| DISEASES 55582 \| KIF27 \| DISEASES 11244 \| ZHX1 \| DISEASES 360 \| AQP3 \| DISEASES 5267 \| SERPINA4 \| DISEASES 90678 \| LRSAM1 \| DISEASES 51117 \| COQ4 \| DISEASES 51129 \| ANGPTL4 \| DISEASES 3479 \| IGF1 \| DISEASES 255738 \| PCSK9 \| DISEASES 8988 \| HSPB3 \| DISEASES 1493 \| CTLA4 \| DISEASES 3596 \| IL13 \| DISEASES 4330 \| MN1 \| DISEASES 9655 \| SOCS5 \| DISEASES 7369 \| UMOD \| DISEASES 157570 \| ESCO2 \| DISEASES 6383 \| SDC2 \| DISEASES 54205 \| CYCS \| DISEASES 10855 \| HPSE \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 23529 \| CLCF1 \| DISEASES 4023 \| LPL \| DISEASES 9688 \| NUP93 \| DISEASES 9024 \| BRSK2 \| DISEASES 27235 \| COQ2 \| DISEASES 4118 \| MAL \| DISEASES 358 \| AQP1 \| DISEASES 5319 \| PLA2G1B \| DISEASES 404217 \| CTXN1 \| DISEASES 998 \| CDC42 \| DISEASES 22882 \| ZHX2 \| DISEASES 1191 \| CLU \| DISEASES 3936 \| LCP1 \| DISEASES 8542 \| APOL1 \| DISEASES 9377 \| COX5A \| DISEASES 5652 \| PRSS8 \| DISEASES 4018 \| LPA \| DISEASES 5345 \| SERPINF2 \| DISEASES 64089 \| SNX16 \| DISEASES 2 \| A2M \| DISEASES 9622 \| KLK4 \| DISEASES 6097 \| RORC \| DISEASES 4094 \| MAF \| DISEASES 6906 \| SERPINA7 \| DISEASES 2811 \| GP1BA \| DISEASES 7490 \| WT1 \| DISEASES 8214 \| DGCR6 \| DISEASES 1287 \| COL4A5 \| DISEASES 55328 \| RNLS \| DISEASES 51004 \| COQ6 \| DISEASES 342184 \| FMN1 \| DISEASES 2152 \| F3 \| DISEASES 23760 \| PITPNB \| DISEASES 3320 \| HSP90AA1 \| DISEASES 8710 \| SERPINB7 \| DISEASES 64412 \| GZF1 \| DISEASES 7430 \| EZR \| DISEASES 5329 \| PLAUR \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 1180 \| CLCN1 \| DISEASES 6609 \| SMPD1 \| DISEASES 7225 \| TRPC6 \| DISEASES 4306 \| NR3C2 \| DISEASES 6187 \| RPS2 \| DISEASES 866 \| SERPINA6 \| DISEASES 5498 \| PPOX \| DISEASES 26762 \| HAVCR1 \| DISEASES 1861 \| TOR1A \| DISEASES 9863 \| MAGI2 \| DISEASES 2335 \| FN1 \| DISEASES 79661 \| NEIL1 \| DISEASES 954 \| ENTPD2 \| DISEASES 4010 \| LMX1B \| DISEASES 7328 \| UBE2H \| DISEASES 1785 \| DNM2 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 6288 \| SAA1 \| DISEASES 2224 \| FDPS \| DISEASES 50485 \| SMARCAL1 \| DISEASES 60 \| ACTB \| DISEASES 23556 \| PIGN \| DISEASES 5699 \| PSMB10 \| DISEASES 55243 \| KIRREL \| DISEASES 23607 \| CD2AP \| DISEASES 2013 \| EMP2 \| DISEASES 84063 \| KIRREL2 \| DISEASES 4311 \| MME \| DISEASES 6721 \| SREBF2 \| DISEASES 10724 \| MGEA5 \| DISEASES 23038 \| WDTC1 \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 28514 \| DLL1 \| DISEASES 1378 \| CR1 \| DISEASES 3075 \| CFH \| DISEASES 9213 \| XPR1 \| DISEASES 7827 \| NPHS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 6446 \| SGK1 \| DISEASES 2214 \| FCGR3A \| DISEASES 1490 \| CTGF \| DISEASES 336 \| APOA2 \| DISEASES 632 \| BGLAP \| DISEASES 284486 \| THEM5 \| DISEASES 57107 \| PDSS2 \| DISEASES 128344 \| PIFO \| DISEASES 3744 \| KCNA10 \| DISEASES 50814 \| NSDHL \| DISEASES 1369 \| CPN1 \| DISEASES 2334 \| AFF2 \| DISEASES 959 \| CD40LG \| DISEASES 27329 \| ANGPTL3 \| DISEASES 163782 \| KANK4 \| DISEASES 953 \| ENTPD1 \| DISEASES 7422 \| VEGFA \| DISEASES 2889 \| RAPGEF1 \| DISEASES 2981 \| GUCA2B \| DISEASES 8879 \| SGPL1 \| DISEASES 23051 \| ZHX3 \| DISEASES 286204 \| CRB2 \| DISEASES 4702 \| NDUFA8 \| DISEASES 2934 \| GSN \| DISEASES 27293 \| SMPDL3B \| DISEASES 7099 \| TLR4 \| DISEASES 1896 \| EDA \| DISEASES 3339 \| HSPG2 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 23352 \| UBR4 \| DISEASES 2155 \| F7 \| DISEASES 50943 \| FOXP3 \| DISEASES 23590 \| PDSS1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 4878 \| NPPA \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 2262 \| GPC5 \| DISEASES 7056 \| THBD \| DISEASES 8718 \| TNFRSF25 \| DISEASES 83715 \| ESPN \| DISEASES 8029 \| CUBN \| DISEASES 6520 \| SLC3A2 \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 375790 \| AGRN \| DISEASES 1906 \| EDN1 \| DISEASES 79886 \| CAAP1 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 150084 \| IGSF5 \| DISEASES 6557 \| SLC12A1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 55858 \| TMEM165 \| DISEASES 23189 \| KANK1 \| DISEASES 402682 \| UFSP1 \| DISEASES 64423 \| INF2 \| DISEASES 11346 \| SYNPO \| DISEASES 3426 \| CFI \| DISEASES 5530 \| PPP3CA \| DISEASES 6696 \| SPP1 \| DISEASES 174 \| AFP \| DISEASES 1285 \| COL4A3 \| DISEASES 1286 \| COL4A4 \| DISEASES 30011 \| SH3KBP1 \| DISEASES 340990 \| OTOG \| DISEASES 11281 \| POU6F2 \| DISEASES 10525 \| HYOU1 \| DISEASES 7018 \| TF \| DISEASES 221935 \| SDK1 \| DISEASES 4648 \| MYO7B \| DISEASES 10213 \| PSMD14 \| DISEASES 154810 \| AMOTL1 \| DISEASES 84942 \| WDR73 \| DISEASES 11277 \| TREX1 \| DISEASES 23109 \| DDN \| DISEASES 6457 \| SH3GL3 \| DISEASES 197 \| AHSG \| DISEASES 5005 \| ORM2 \| DISEASES 25959 \| KANK2 \| DISEASES 5076 \| PAX2 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 6559 \| SLC12A3 \| DISEASES 2195 \| FAT1 \| DISEASES 221981 \| THSD7A \| DISEASES 9351 \| SLC9A3R2 \| DISEASES 8867 \| SYNJ1 \| DISEASES 389549 \| FEZF1 \| DISEASES 3586 \| IL10 \| DISEASES 55230 \| USP40 \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 2638 \| GC \| DISEASES 373156 \| GSTK1 \| DISEASES 917 \| CD3G \| DISEASES 1207 \| CLNS1A \| DISEASES 84623 \| KIRREL3 \| DISEASES 4798 \| NFRKB \| DISEASES 930 \| CD19 \| DISEASES 80790 \| CMIP \| DISEASES 8972 \| MGAM \| DISEASES 4157 \| MC1R \| DISEASES 567 \| B2M \| DISEASES 6139 \| RPL17 \| DISEASES 344 \| APOC2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	185
Disease	nephrotic syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:131) HP:0000093 \| Proteinuria \| 54 HP:0000112 \| Nephropathy \| 36 HP:0012578 \| Membranous glomerulonephritis \| 23 HP:0000083 \| Renal insufficiency \| 19 HP:0000969 \| Dropsy \| 18 HP:0000099 \| Glomerular nephritis \| 15 HP:0000096 \| Glomerulosclerosis \| 15 HP:0001919 \| Acute renal failure \| 14 HP:0000097 \| focal glomerulosclerosis \| 12 HP:0001907 \| Thromboembolic disease \| 10 HP:0000123 \| Nephritis \| 9 HP:0012579 \| Minimal change glomerulonephritis \| 8 HP:0002907 \| Microhematuria \| 8 HP:0011034 \| Amyloid disease \| 8 HP:0002664 \| Neoplasia \| 7 HP:0003774 \| End-stage renal failure \| 6 HP:0000790 \| Hematuria \| 6 HP:0000821 \| Underactive thyroid \| 5 HP:0003073 \| Hypoalbuminaemia \| 5 HP:0100820 \| Glomerulopathy \| 4 HP:0003077 \| Hyperlipidemia \| 4 HP:0012597 \| Heavy proteinuria \| 4 HP:0004936 \| Blood clot in vein \| 4 HP:0002586 \| Peritonitis \| 4 HP:0030731 \| Carcinoma \| 3 HP:0012050 \| Anasarca \| 3 HP:0002665 \| Lymphoma \| 3 HP:0002621 \| Atherosclerosis \| 3 HP:0001541 \| Ascites \| 3 HP:0001635 \| Congestive heart failure \| 3 HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0000979 \| Purpura \| 3 HP:0000113 \| Polycystic kidney dysplasia \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0012592 \| Albuminuria \| 3 HP:0100724 \| Hypercoagulability \| 3 HP:0100723 \| Gastrointestinal stroma tumor \| 3 HP:0003124 \| Elevated serum cholesterol \| 2 HP:0012281 \| Chylous ascites \| 2 HP:0012398 \| Peripheral edema \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0004420 \| Arterial thrombosis \| 2 HP:0001917 \| Renal amyloidosis \| 2 HP:0100522 \| Thymoma \| 2 HP:0011947 \| Respiratory infection \| 2 HP:0000822 \| Hypertension \| 2 HP:0002204 \| Pulmonary embolism \| 2 HP:0012531 \| Pain \| 2 HP:0002090 \| Pneumonia \| 2 HP:0001945 \| Fever \| 2 HP:0008064 \| Ichthyosis \| 2 HP:0000252 \| Small head circumference \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0100280 \| Morbus Crohn \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0000855 \| Insulin resistance \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0001941 \| acidemia \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0002110 \| Bronchiectasis \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0100003 \| Peritoneal mesothelioma \| 1 HP:0012594 \| High urine albumin levels \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0100001 \| Malignant mesothelioma \| 1 HP:0001872 \| Platelet abnormalities \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0002576 \| Intussusception \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0010524 \| Agnosia \| 1 HP:0001999 \| Facial dysmorphism \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0002099 \| Asthma \| 1 HP:0002153 \| Elevated serum potassium levels \| 1 HP:0001920 \| Renal artery stenosis \| 1 HP:0003075 \| Hypoproteinemia \| 1 HP:0002155 \| Increased triglycerides \| 1 HP:0000230 \| Inflamed gums \| 1 HP:0004746 \| Dense deposit disease \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0000832 \| Primary hypothyroidism \| 1 HP:0011459 \| Esophageal carcinoma \| 1 HP:0012234 \| Agranulocytosis \| 1 HP:0003259 \| Increased serum creatinine \| 1 HP:0001967 \| Diffuse mesangial sclerosis \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0030760 \| Kidney fibrosis \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0100806 \| Sepsis \| 1 HP:0004713 \| Reversible renal failure \| 1 HP:0008677 \| Congenital nephrosis \| 1 HP:0001004 \| Lymphatic obstruction \| 1 HP:0005576 \| Renal interstitial fibrosis \| 1 HP:0007430 \| Generalized edema \| 1 HP:0008682 \| Renal tubular necrosis \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0100817 \| Renovascular hypertension \| 1 HP:0011967 \| Hypocupremia \| 1 HP:0030843 \| Cardiac amyloidosis \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0100002 \| Pleural mesothelioma \| 1 HP:0012226 \| Ovarian teratoma \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0002149 \| Hyperuricemia \| 1 HP:0004836 \| Acute promyelocytic leukemia \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0001250 \| Seizures \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0004313 \| Decreased immunoglobulin level \| 1 HP:0000133 \| Mixed gonadal dysgenesis \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0002013 \| Emesis \| 1 HP:0001639 \| Hypertrophic cardiomyopathy \| 1 HP:0003764 \| Naevus \| 1 HP:0011510 \| Drusen \| 1 HP:0002315 \| Headaches \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001903 \| Anemia \| 1 HP:0001892 \| Bleeding diathesis \| 1

Disease ID	185
Disease	nephrotic syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:202) C2700526 \| erythrocytosis C2700513 \| aplastic anemia C2585960 \| heterozygous protein c deficiency C2364133 \| infection C2062980 \| pneumococcal peritonitis C2062979 \| spontaneous bacterial peritonitis C2025995 \| cellulitis C1963266 \| uveitis C1963211 \| pericarditis C1963154 \| renal failure C1963138 \| hypertension C1963091 \| diarrhea C1962972 \| proteinuria C1962966 \| retinopathy C1961100 \| erectile dysfunction C1959629 \| seizure C1956391 \| temporal arteritis C1839611 \| n syndrome C1735914 \| recurrent pulmonary embolism C1704212 \| embolism C1567741 \| hereditary nephritis C1555754 \| cardiovascular disease C1522133 \| hypercholesterolemia C1421375 \| congenital erythropoietic porphyria C1412610 \| antithrombin iii deficiency C1398810 \| glomerulopathy C1373218 \| immunosuppression C1368829 \| hyperalimentation C1366529 \| familial hypercholesterolemia C1333523 \| factor vii deficiency C1253937 \| pericardial effusion C1000483 \| anemia C0878787 \| growth failure C0876993 \| ventricular thrombosis C0856759 \| unilateral renal artery stenosis C0856169 \| endothelial dysfunction C0854142 \| aortic thrombosis C0853689 \| secondary hyperlipidemia C0850705 \| acquired toxoplasmosis C0747111 \| ovarian vein thrombosis C0743971 \| chronic fever C0740985 \| acute anemia C0740577 \| acute abdominal pain C0730345 \| microalbuminuria C0730302 \| progressive outer retinal necrosis C0729233 \| dissecting aneurysm of the thoracic aorta C0699885 \| carcinoma of urinary bladder C0684249 \| lung cancer C0677886 \| ovarian carcinoma C0558354 \| carcinoma of the palate C0546817 \| fluid overload C0517555 \| venous thrombosis C0403447 \| chronic renal disease C0398625 \| protein c deficiency C0398623 \| thrombophilia C0398623 \| hypercoagulable state C0398623 \| hypercoagulability C0393972 \| spinal cord infarction C0376545 \| hematological malignancies C0376185 \| hyporeninemic hypoaldosteronism C0349530 \| early gastric cancer C0348996 \| disseminated strongyloidiasis C0342951 \| hypervitaminosis C0338575 \| superior sagittal sinus thrombosis C0338573 \| intracranial venous sinus thrombosis C0338573 \| cerebral venous sinus thrombosis C0334316 \| hypernephroid tumor C0334121 \| inflammatory myofibroblastic tumor C0333497 \| segmental glomerulosclerosis C0333245 \| massive oedema C0281479 \| systemic amyloidosis C0281479 \| primary systemic amyloidosis C0280089 \| pulmonary carcinoid tumor C0280089 \| carcinoid tumor of the lung C0276687 \| disseminated cryptococcosis C0275583 \| pulmonary nocardiosis C0272375 \| antithrombin deficiency C0270612 \| leukoencephalopathy C0268731 \| glomerular diseases C0268731 \| glomerular disease C0268709 \| renal tubular defect C0268382 \| renal amyloidosis C0265251 \| taybi syndrome C0265050 \| vena cava thrombosis C0263361 \| psoriasis vulgaris C0259744 \| dysproteinemia C0242339 \| dyslipidemias C0242339 \| dyslipidemia C0242339 \| dyslipidaemia C0240035 \| interstitial fibrosis C0238457 \| renal vein thrombosis C0235950 \| zinc deficiency C0235259 \| subcapsular cataracts C0221757 \| alpha 1-antitrypsin deficiency C0221406 \| cushing's disease C0221239 \| rapidly progressive glomerulonephritis C0221238 \| mesangial proliferative glomerulonephritis C0206182 \| lymphomatoid papulosis C0205721 \| nosocomial infection C0162557 \| fulminant hepatic failure C0154251 \| lipid metabolism disorders C0154251 \| lipid disorders C0154251 \| disorders of lipid metabolism C0152456 \| strawberry gallbladder C0151945 \| cerebral venous thrombosis C0151942 \| arterial thrombosis C0149985 \| secondary syphilis C0149937 \| acute interstitial nephritis C0149925 \| small cell lung cancer C0149871 \| deep-vein thrombosis C0087086 \| thrombi C0086438 \| hypogammaglobulinemia C0062527 \| hepatitis b C0043121 \| wernicke's encephalopathy C0042029 \| urinary tract infection C0041912 \| upper respiratory infections C0041782 \| deficiency anemia C0040560 \| congenital toxoplasmosis C0040558 \| toxoplasmosis C0040053 \| thrombosis C0040038 \| thromboembolism C0039263 \| takayasu's disease C0039263 \| takayasu's arteritis C0038463 \| strongyloidiasis C0038454 \| cerebral infarction C0037889 \| hereditary spherocytosis C0037278 \| skin infection C0036992 \| short bowel syndrome C0035305 \| retinal detachments C0034074 \| pulmonary infarction C0034065 \| pulmonary embolism C0033838 \| kimura's disease C0032587 \| polyradiculoneuropathy C0032461 \| polycythaemia C0032285 \| pneumonitis C0032285 \| pneumoniae C0031306 \| phagocytic dysfunction C0031154 \| peritonitis C0030804 \| cicatricial pemphigoid C0029405 \| hyperparathyroid bone disease C0027697 \| nephritis C0027092 \| myopia C0027051 \| myocardial infarction C0026764 \| myeloma C0026265 \| mitral valve disease C0025289 \| meningitis C0024419 \| macroglobulinemia C0024314 \| lymphoproliferative disease C0024141 \| systemic lupus erythematosus C0023890 \| liver cirrhosis C0023479 \| acute myelomonocytic leukemia C0023467 \| acute myeloid leukemia C0023434 \| chronic lymphocytic leukemia C0022679 \| cystic kidney C0022661 \| end-stage renal failure C0022661 \| chronic renal failure C0022660 \| acute renal failure C0022398 \| hyperimmunoglobulin e syndrome C0021933 \| intussusception C0020981 \| angioimmunoblastic lymphadenopathy with dysproteinemia (aild) C0020639 \| hypoproteinemia C0020625 \| hyponatremia C0020545 \| renovascular hypertension C0020488 \| sodium retention C0020476 \| hyperlipoproteinemia C0020473 \| hyperlipidemia C0020473 \| hyperlipidaemia C0020473 \| hyperlipemia C0020438 \| hypercalciuria C0020428 \| hyperaldosteronism C0020312 \| hydrothorax C0019104 \| hemorrhagic fever C0018021 \| goiter C0017668 \| focal segmental glomerulosclerosis C0017665 \| membranous nephropathy C0017662 \| membranoproliferative glomerulonephritis C0017661 \| iga nephropathy C0017658 \| glomerulonephritis C0015526 \| factor xii deficiency C0015499 \| factor v deficiency C0014118 \| endocarditis C0014009 \| empyema C0013604 \| oedema C0013502 \| hydatid disease C0011854 \| type 1 diabetes mellitus C0010481 \| cushing syndrome C0010346 \| crohn's disease C0010068 \| coronary heart disease C0008732 \| chylous ascites C0008732 \| chyloperitoneum C0008049 \| chickenpox C0006840 \| candidosis C0005944 \| metabolic bone disease C0005940 \| bone disease C0005779 \| coagulopathy C0004659 \| bacteriuria C0004623 \| bacterial infection C0004153 \| atherosclerosis C0002871 \| anaemia C0001197 \| acrodermatitis C0000737 \| abdominal pain C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:69) C0033687 \| proteinuria \| 54 C0017665 \| membranous nephropathy \| 21 C0035078 \| renal failure \| 16 C0017658 \| glomerulonephritis \| 15 C0040053 \| thrombosis \| 14 C0333497 \| segmental glomerulosclerosis \| 13 C0009450 \| infection \| 13 C0017668 \| focal segmental glomerulosclerosis \| 11 C0027697 \| nephritis \| 9 C0017661 \| iga nephropathy \| 8 C0040038 \| thromboembolism \| 7 C0398623 \| hypercoagulable state \| 6 C0033838 \| kimura's disease \| 5 C0022660 \| acute renal failure \| 5 C1839611 \| n syndrome \| 4 C0020473 \| hyperlipidemia \| 4 C0031154 \| peritonitis \| 4 C0149985 \| secondary syphilis \| 4 C0042487 \| venous thrombosis \| 4 C1398810 \| glomerulopathy \| 4 C0242339 \| dyslipidemia \| 3 C0019163 \| hepatitis b \| 3 C0004153 \| atherosclerosis \| 3 C0022679 \| cystic kidney \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0155776 \| renal vein thrombosis \| 3 C0007785 \| cerebral infarction \| 3 C0398623 \| hypercoagulability \| 3 C0276687 \| disseminated cryptococcosis \| 2 C0021079 \| immunosuppression \| 2 C0268382 \| renal amyloidosis \| 2 C0034065 \| pulmonary embolism \| 2 C0013604 \| oedema \| 2 C0151942 \| arterial thrombosis \| 2 C0268731 \| glomerular disease \| 2 C0020443 \| hypercholesterolemia \| 2 C0022661 \| chronic renal failure \| 2 C0013922 \| embolism \| 2 C0020488 \| sodium retention \| 2 C0020538 \| hypertension \| 2 C0010346 \| crohn's disease \| 2 C0854142 \| aortic thrombosis \| 1 C0032461 \| polycythaemia \| 1 C0240035 \| interstitial fibrosis \| 1 C0004623 \| bacterial infection \| 1 C0042029 \| urinary tract infection \| 1 C0856169 \| endothelial dysfunction \| 1 C0730345 \| microalbuminuria \| 1 C0020545 \| renovascular hypertension \| 1 C0022661 \| end-stage renal failure \| 1 C0008732 \| chylous ascites \| 1 C0007642 \| cellulitis \| 1 C0021933 \| intussusception \| 1 C0242379 \| lung cancer \| 1 C0010068 \| coronary heart disease \| 1 C0008732 \| chyloperitoneum \| 1 C0546817 \| fluid overload \| 1 C0005779 \| coagulopathy \| 1 C0000737 \| abdominal pain \| 1 C0086438 \| hypogammaglobulinemia \| 1 C0035309 \| retinopathy \| 1 C0338573 \| cerebral venous sinus thrombosis \| 1 C0002871 \| anemia \| 1 C0376545 \| hematological malignancies \| 1 C0027051 \| myocardial infarction \| 1 C0020639 \| hypoproteinemia \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0032587 \| polyradiculoneuropathy \| 1 C1527405 \| erythrocytosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:16)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	23994685	5243	ABCB1	umls:C0027726	BeFree	Our data suggested that MDR1 C3435T or G2677T/A gene polymorphisms are risk factors of increased susceptibility, earlier onset of NS, and steroid resistance.	0.003452799	2013	ABCB1	7	87509329	A	T,G
rs16946160	21441931	2262	GPC5	umls:C0027726	GAD	[Common variation in GPC5 is associated with acquired nephrotic syndrome.]	0.242638474	2011	GPC5	13	91551559	G	A
rs16946160	21441931	2262	GPC5	umls:C0027726	GWASCAT	Common variation in GPC5 is associated with acquired nephrotic syndrome.	0.242638474	2011	GPC5	13	91551559	G	A
rs200042397	16752799	7827	NPHS2	umls:C0027726	BeFree	A functional polymorphism of NPHS2 gene--R229Q was associated with a late-onset nephrotic syndrome and also with an increased risk of microalbuminuria in the general population.	0.300654662	2006	NPHS2;AXDND1	1	179552616	T	C
rs200042397	23515051	7827	NPHS2	umls:C0027726	BeFree	Of the autosomal recessive and the sporadic cases, 13 and 6%, respectively, were found to have podocin-associated nephrotic syndrome, and 56% of them were compound heterozygous for the nonneutral p.R229Q polymorphism.	0.300654662	2013	NPHS2;AXDND1	1	179552616	T	C
rs200042397	24072153	7827	NPHS2	umls:C0027726	BeFree	R229Q polymorphism of NPHS2 gene in patients with late-onset steroid-resistance nephrotic syndrome: a preliminary study.	0.300654662	2013	NPHS2;AXDND1	1	179552616	T	C
rs2032582	23994685	5243	ABCB1	umls:C0027726	BeFree	Our data suggested that MDR1 C3435T or G2677T/A gene polymorphisms are risk factors of increased susceptibility, earlier onset of NS, and steroid resistance.	0.003452799	2013	ABCB1	7	87531302	A	T,C
rs33388	18343955	595	CCND1	umls:C0027726	BeFree	We genotyped 118 children diagnosed with NS who initially responded to oral GC treatment [steroid-responsive nephrotic syndrome (SRNS) group] and 136 healthy children for three intron B single nucleotide polymorphisms of NR3C1, namely Bcl I (C/G), rs33389 (C/T) and rs33388 (A/T).	0.000271442	2008	NR3C1	5	143317730	A	T
rs33389	18343955	595	CCND1	umls:C0027726	BeFree	We genotyped 118 children diagnosed with NS who initially responded to oral GC treatment [steroid-responsive nephrotic syndrome (SRNS) group] and 136 healthy children for three intron B single nucleotide polymorphisms of NR3C1, namely Bcl I (C/G), rs33389 (C/T) and rs33388 (A/T).	0.000271442	2008	NR3C1	5	143320934	C	T
rs3814995	24231487	4868	NPHS1	umls:C0027726	BeFree	We report a child aged 4 months with steroid-resistant NS who had polymorphism of NPHS1 (E117K) and mutation of NPHS2 (P118L).	0.116148884	2014	NPHS1;KIRREL2	19	35851310	C	G,T
rs3814995	24231487	7827	NPHS2	umls:C0027726	BeFree	We report a child aged 4 months with steroid-resistant NS who had polymorphism of NPHS1 (E117K) and mutation of NPHS2 (P118L).	0.300654662	2014	NPHS1;KIRREL2	19	35851310	C	G,T
rs386833892	20172850	4868	NPHS1	umls:C0027726	BeFree	Surprisingly, out of the two siblings with the homozygous novel mutation L587R in NPHS1, only one developed nephrotic syndrome before the age of 90 days, while the other one did not manifest until the age of 2 years.	0.116148884	2010	NPHS1	19	35845538	A	C
rs437168	25599733	4868	NPHS1	umls:C0027726	BeFree	Our findings indicate that NPHS1 rs437168, but not NPHS2 rs61747728 variant, is associated with NS.	0.116148884	2014	NPHS1	19	35843517	G	A,C
rs437168	25599733	7827	NPHS2	umls:C0027726	BeFree	Our findings indicate that NPHS1 rs437168, but not NPHS2 rs61747728 variant, is associated with NS.	0.300654662	2014	NPHS1	19	35843517	G	A,C
rs61747728	25599733	4868	NPHS1	umls:C0027726	BeFree	Our findings indicate that NPHS1 rs437168, but not NPHS2 rs61747728 variant, is associated with NS.	0.116148884	2014	NPHS2	1	179557079	C	T
rs61747728	25599733	7827	NPHS2	umls:C0027726	BeFree	Our findings indicate that NPHS1 rs437168, but not NPHS2 rs61747728 variant, is associated with NS.	0.300654662	2014	NPHS2	1	179557079	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:2)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
13	92203813	rs16946160	G	A	rs16946160	21441931	3.00E-07	NA	1.39	[1.22-1.57]	195 Japanese ancestry cases; 1,546 Japanese ancestry controls	Japanese(1741)	ALL(1741)	ASN(1741)	ALL(1741)	Nephrotic syndrome (acquired)	HPOID:0000100	Nephrotic syndrome	DOID:1184	nephrotic syndrome	D009404	Nephrotic Syndrome	NA	NA	Nephrosis	rs16946160-A	Research Support, Non-U.S. Gov't	G	GPC5
20	46779235	rs11086243	C	T	rs11086243	21441931	3.00E-06	NA	1.37	[1.20-1.57]	195 Japanese ancestry cases; 1,546 Japanese ancestry controls	Japanese(1741)	ALL(1741)	ASN(1741)	ALL(1741)	Nephrotic syndrome (acquired)	HPOID:0000100	Nephrotic syndrome	DOID:1184	nephrotic syndrome	D009404	Nephrotic Syndrome	NA	NA	Nephrosis	rs11086243-T	Research Support, Non-U.S. Gov't	T	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:31)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0027726	aminocaproic acid	D015119	60-32-2	nephrotic syndrome	MESH:D009404	therapeutic	11304663
C0027726	ampicillin	D000667	69-53-4	nephrotic syndrome	MESH:D009404	marker/mechanism	1630702
C0027726	benazepril	C044946	86541-75-5	nephrotic syndrome	MESH:D009404	therapeutic	10515446
C0027726	chlorambucil	D002699	305-03-3	nephrotic syndrome	MESH:D009404	marker/mechanism	2797556
C0027726	chlorambucil	D002699	305-03-3	nephrotic syndrome	MESH:D009404	therapeutic	17211287
C0027726	cyclophosphamide	D003520	50-18-0	nephrotic syndrome	MESH:D009404	marker/mechanism	2797556
C0027726	cyclophosphamide	D003520	50-18-0	nephrotic syndrome	MESH:D009404	therapeutic	15334202
C0027726	cyclosporine	D016572	59865-13-3	nephrotic syndrome	MESH:D009404	marker/mechanism	17019561
C0027726	cyclosporine	D016572	59865-13-3	nephrotic syndrome	MESH:D009404	therapeutic	11598405
C0027726	diclofenac	D004008	15307-86-5	nephrotic syndrome	MESH:D009404	marker/mechanism	10444806
C0027726	ethosuximide	D005013	77-67-8	nephrotic syndrome	MESH:D009404	marker/mechanism	623072
C0027726	fenoprofen	D005279	31879-05-7	nephrotic syndrome	MESH:D009404	marker/mechanism	10052505
C0027726	foscarnet	D017245	4428-95-9	nephrotic syndrome	MESH:D009404	marker/mechanism	10231404
C0027726	griseofulvin	D006118	126-07-8	nephrotic syndrome	MESH:D009404	marker/mechanism	7577414
C0027726	indomethacin	D007213	53-86-1	nephrotic syndrome	MESH:D009404	therapeutic	7172499
C0027726	mephenytoin	D008617	1950/12/4	nephrotic syndrome	MESH:D009404	marker/mechanism	1246508
C0027726	nabumetone	C035605	42924-53-8	nephrotic syndrome	MESH:D009404	marker/mechanism	8570441
C0027726	pamidronate	C019248	40391-99-9	nephrotic syndrome	MESH:D009404	marker/mechanism	11979358
C0027726	peginterferon alfa-2b	C417083	-	nephrotic syndrome	MESH:D009404	marker/mechanism	17987400
C0027726	phenytoin	D010672	57-41-0	nephrotic syndrome	MESH:D009404	marker/mechanism	2496325
C0027726	piroxicam	D010894	36322-90-4	nephrotic syndrome	MESH:D009404	marker/mechanism	8298379
C0027726	propranolol	D011433	525-66-6	nephrotic syndrome	MESH:D009404	marker/mechanism	1268509
C0027726	ribavirin	D012254	36791-04-5	nephrotic syndrome	MESH:D009404	marker/mechanism	12080234
C0027726	rifampin	D012293	13292-46-1	nephrotic syndrome	MESH:D009404	marker/mechanism	2782777
C0027726	sirolimus	D020123	53123-88-9	nephrotic syndrome	MESH:D009404	marker/mechanism	16504675
C0027726	sulindac	D013467	38194-50-2	nephrotic syndrome	MESH:D009404	marker/mechanism	3208459
C0027726	thalidomide	D013792	50-35-1	nephrotic syndrome	MESH:D009404	therapeutic	15182131
C0027726	tiopronin	D008625	1953/2/2	nephrotic syndrome	MESH:D009404	marker/mechanism	2250412
C0027726	tolmetin	D014046	26171-23-3	nephrotic syndrome	MESH:D009404	marker/mechanism	2773972
C0027726	trimethadione	D014293	127-48-0	nephrotic syndrome	MESH:D009404	marker/mechanism	4631174
C0027726	vincristine	D014750	-	nephrotic syndrome	MESH:D009404	therapeutic	9655358

FDA approved drug and dosage information(Total Drugs:2)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D009404	rapamune	sirolimus	1MG/ML	SOLUTION;ORAL	Prescription	None	Yes	Yes
MESH:D009404	rapamune	sirolimus	1MG	TABLET;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:2)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D009404	11/3/2005	rapamune	sirolimus	Prophylaxis of organ rejection in patients undergoing renal transplants	Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric (	Labeling	B	-	-	-	Wyeth	11/17/2004	FALSE'
MESH:D009404	11/3/2005	rapamune	sirolimus	Prophylaxis of organ rejection in patients undergoing renal transplants	Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric (	Labeling	B	-	-	-	Wyeth	11/17/2004	FALSE'