PedAM

Pediatric Disease Annotations & Medicines


	nephrolithiasis

Disease ID	282
Disease	nephrolithiasis
Definition	Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
Synonym	calculi, kidney calculi, renal calculus kidney calculus of kidney calculus, kidney calculus, renal kidney calculi kidney calculi [disease/finding] kidney calculus kidney stone kidney stone (disorder) kidney stones kidney, calculus kidneys--calculi nephrolith nephroliths renal calculi renal calculus renal calculus nos renal calculus nos (disorder) renal calculus or stone renal stone renal stones stone in kidney stone, kidney stones, kidney
OMIM	OMIM:167030
DOID	DOID:585
ICD10	ICD10CM:N20.0
UMLS	C0022650
MeSH	D007669 D053040
SNOMED-CT	SNOMEDCT_US_2016_09_01:95570007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:54) C0085413 \| autosomal dominant polycystic kidney disease \| 4 C0948265 \| metabolic syndrome \| 4 C0221002 \| primary hyperparathyroidism \| 4 C0085413 \| autosomal dominant polycystic kidney \| 4 C0027709 \| nephrocalcinosis \| 4 C0020502 \| hyperparathyroidism \| 3 C0022681 \| medullary sponge kidney \| 3 C0035078 \| renal failure \| 3 C0028754 \| obesity \| 3 C0020538 \| hypertension \| 3 C0033687 \| proteinuria \| 2 C0011847 \| diabetes \| 2 C0021831 \| bowel disease \| 2 C0022658 \| kidney disease \| 2 C0011860 \| type 2 diabetes \| 2 C0022679 \| cystic kidney \| 2 C0021390 \| inflammatory bowel disease \| 2 C0022661 \| end stage renal disease \| 1 C0004623 \| bacterial infection \| 1 C0010346 \| crohn's disease \| 1 C0151468 \| thyroid adenoma \| 1 C0020437 \| hypercalcemia \| 1 C0024623 \| gastric cancer \| 1 C0005283 \| beta thalassemia \| 1 C0029456 \| osteoporosis \| 1 C0262587 \| parathyroid adenoma \| 1 C0007570 \| celiac disease \| 1 C0028860 \| lowe syndrome \| 1 C1565489 \| renal insufficiency \| 1 C0027697 \| nephritis \| 1 C0010674 \| cystic fibrosis \| 1 C0022661 \| chronic kidney disease \| 1 C0020295 \| hydronephrosis \| 1 C0022661 \| end-stage renal disease \| 1 C0085113 \| neurofibromatosis \| 1 C0740394 \| hyperuricaemia \| 1 C0011334 \| cavities \| 1 C0001973 \| alcoholism \| 1 C0022658 \| renal disease \| 1 C0022658 \| nephropathy \| 1 C0022661 \| end stage kidney disease \| 1 C0001126 \| renal tubular acidosis \| 1 C0020501 \| primary hyperoxaluria \| 1 C1704375 \| hypophosphatemic rickets \| 1 C0019069 \| hemophilia \| 1 C0011849 \| diabetes mellitus \| 1 C0001430 \| adenoma \| 1 C0035579 \| rickets \| 1 C0018099 \| gout \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0034186 \| pyelonephritis \| 1 C0027022 \| myeloproliferative disease \| 1 C0023890 \| cirrhosis \| 1 C0026769 \| multiple sclerosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) SOD1 \| 6647 \| CTD_human POMC \| 5443 \| CTD_human SPP1 \| 6696 \| CTD_human CAT \| 847 \| CTD_human GSTP1 \| 2950 \| CTD_human TRPM7 \| 54822 \| CTD_human CLDN14 \| 23562 \| CTD_human;GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:20) 259 \| AMBP \| infer 846 \| CASR \| infer 23562 \| CLDN14 \| infer 2147 \| F2 \| infer 6283 \| S100A12 \| infer 6279 \| S100A8 \| infer 6280 \| S100A9 \| infer 6696 \| SPP1 \| infer 7031 \| TFF1 \| infer 7369 \| UMOD \| infer 7421 \| VDR \| infer 160851 \| DGKH \| infer 84182 \| FAM188B \| infer 2335 \| FN1 \| infer 3339 \| HSPG2 \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 5328 \| PLAU \| infer 10636 \| RGS14 \| infer 56606 \| SLC2A9 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:240) 1080 \| CFTR \| DISEASES 11136 \| SLC7A9 \| DISEASES 340533 \| KIAA2022 \| DISEASES 28962 \| OSTM1 \| DISEASES 9812 \| KIAA0141 \| DISEASES 6561 \| SLC13A1 \| DISEASES 368 \| ABCC6 \| DISEASES 2999 \| GZMH \| DISEASES 1591 \| CYP24A1 \| DISEASES 10005 \| ACOT8 \| DISEASES 479 \| ATP12A \| DISEASES 1666 \| DECR1 \| DISEASES 5444 \| PON1 \| DISEASES 6347 \| CCL2 \| DISEASES 9761 \| MLEC \| DISEASES 1594 \| CYP27B1 \| DISEASES 4256 \| MGP \| DISEASES 64902 \| AGXT2 \| DISEASES 2677 \| GGCX \| DISEASES 525 \| ATP6V1B1 \| DISEASES 1185 \| CLCN6 \| DISEASES 8074 \| FGF23 \| DISEASES 5507 \| PPP1R3C \| DISEASES 23397 \| NCAPH \| DISEASES 847 \| CAT \| DISEASES 7374 \| UNG \| DISEASES 10047 \| CST8 \| DISEASES 6779 \| STATH \| DISEASES 22863 \| ATG14 \| DISEASES 2678 \| GGT1 \| DISEASES 3630 \| INS \| DISEASES 259232 \| NALCN \| DISEASES 3854 \| KRT6B \| DISEASES 56301 \| SLC7A10 \| DISEASES 10343 \| PKDREJ \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 1401 \| CRP \| DISEASES 1131 \| CHRM3 \| DISEASES 2012 \| EMP1 \| DISEASES 6926 \| TBX3 \| DISEASES 3569 \| IL6 \| DISEASES 570 \| BAAT \| DISEASES 9581 \| PREPL \| DISEASES 6519 \| SLC3A1 \| DISEASES 1419 \| CRYGB \| DISEASES 4069 \| LYZ \| DISEASES 1182 \| CLCN3 \| DISEASES 999 \| CDH1 \| DISEASES 9368 \| SLC9A3R1 \| DISEASES 495 \| ATP4A \| DISEASES 8455 \| ATRN \| DISEASES 50507 \| NOX4 \| DISEASES 80271 \| ITPKC \| DISEASES 23476 \| BRD4 \| DISEASES 4036 \| LRP2 \| DISEASES 822 \| CAPG \| DISEASES 5443 \| POMC \| DISEASES 10686 \| CLDN16 \| DISEASES 56606 \| SLC2A9 \| DISEASES 10723 \| SLC12A7 \| DISEASES 6550 \| SLC9A3 \| DISEASES 259 \| AMBP \| DISEASES 56302 \| TRPV5 \| DISEASES 5243 \| ABCB1 \| DISEASES 3700 \| ITIH4 \| DISEASES 6523 \| SLC5A1 \| DISEASES 7112 \| TMPO \| DISEASES 5972 \| REN \| DISEASES 5746 \| PTH2R \| DISEASES 5868 \| RAB5A \| DISEASES 3697 \| ITIH1 \| DISEASES 3934 \| LCN2 \| DISEASES 64849 \| SLC13A3 \| DISEASES 7082 \| TJP1 \| DISEASES 5741 \| PTH \| DISEASES 5495 \| PPM1B \| DISEASES 3694 \| ITGB6 \| DISEASES 23250 \| ATP11A \| DISEASES 1105 \| CHD1 \| DISEASES 56934 \| CA10 \| DISEASES 1836 \| SLC26A2 \| DISEASES 286053 \| NSMCE2 \| DISEASES 163786 \| SASS6 \| DISEASES 653361 \| NCF1 \| DISEASES 1636 \| ACE \| DISEASES 7031 \| TFF1 \| DISEASES 84661 \| DPY30 \| DISEASES 9497 \| SLC4A7 \| DISEASES 213 \| ALB \| DISEASES 149461 \| CLDN19 \| DISEASES 308 \| ANXA5 \| DISEASES 3251 \| HPRT1 \| DISEASES 189 \| AGXT \| DISEASES 4543 \| MTNR1A \| DISEASES 140738 \| TMEM37 \| DISEASES 375611 \| SLC26A5 \| DISEASES 7369 \| UMOD \| DISEASES 7569 \| ZNF182 \| DISEASES 5002 \| SLC22A18 \| DISEASES 79660 \| PPP1R3B \| DISEASES 2147 \| F2 \| DISEASES 8534 \| CHST1 \| DISEASES 115111 \| SLC26A7 \| DISEASES 763 \| CA5A \| DISEASES 358 \| AQP1 \| DISEASES 26249 \| KLHL3 \| DISEASES 133522 \| PPARGC1B \| DISEASES 9380 \| GRHPR \| DISEASES 92745 \| SLC38A5 \| DISEASES 7592 \| ZNF41 \| DISEASES 4691 \| NCL \| DISEASES 56776 \| FMN2 \| DISEASES 1068 \| CETN1 \| DISEASES 65012 \| SLC26A10 \| DISEASES 6888 \| TALDO1 \| DISEASES 6569 \| SLC34A1 \| DISEASES 3615 \| IMPDH2 \| DISEASES 5745 \| PTH1R \| DISEASES 56975 \| FAM20C \| DISEASES 84876 \| ORAI1 \| DISEASES 57649 \| PHF12 \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 1187 \| CLCNKA \| DISEASES 51004 \| COQ6 \| DISEASES 4221 \| MEN1 \| DISEASES 160851 \| DGKH \| DISEASES 857 \| CAV1 \| DISEASES 23562 \| CLDN14 \| DISEASES 1180 \| CLCN1 \| DISEASES 9639 \| ARHGEF10 \| DISEASES 347344 \| ZNF81 \| DISEASES 115019 \| SLC26A9 \| DISEASES 54345 \| SOX18 \| DISEASES 5174 \| PDZK1 \| DISEASES 165904 \| XIRP1 \| DISEASES 875 \| CBS \| DISEASES 26762 \| HAVCR1 \| DISEASES 3614 \| IMPDH1 \| DISEASES 1811 \| SLC26A3 \| DISEASES 128637 \| TBC1D20 \| DISEASES 79849 \| PDZD3 \| DISEASES 11060 \| WWP2 \| DISEASES 26084 \| ARHGEF26 \| DISEASES 8794 \| TNFRSF10C \| DISEASES 22931 \| RAB18 \| DISEASES 345456 \| PFN3 \| DISEASES 25782 \| RAB3GAP2 \| DISEASES 55503 \| TRPV6 \| DISEASES 4860 \| PNP \| DISEASES 133308 \| SLC9B2 \| DISEASES 10861 \| SLC26A1 \| DISEASES 10724 \| MGEA5 \| DISEASES 142680 \| SLC34A3 \| DISEASES 284129 \| SLC26A11 \| DISEASES 5867 \| RAB4A \| DISEASES 79577 \| CDC73 \| DISEASES 10090 \| UST \| DISEASES 6045 \| RNF2 \| DISEASES 55811 \| ADCY10 \| DISEASES 5451 \| POU2F1 \| DISEASES 632 \| BGLAP \| DISEASES 6280 \| S100A9 \| DISEASES 1369 \| CPN1 \| DISEASES 112817 \| HOGA1 \| DISEASES 4952 \| OCRL \| DISEASES 7809 \| BSND \| DISEASES 84871 \| AGBL4 \| DISEASES 11182 \| SLC2A6 \| DISEASES 89891 \| WDR34 \| DISEASES 23637 \| RABGAP1 \| DISEASES 1896 \| EDA \| DISEASES 316 \| AOX1 \| DISEASES 22919 \| MAPRE1 \| DISEASES 1188 \| CLCNKB \| DISEASES 9371 \| KIF3B \| DISEASES 1184 \| CLCN5 \| DISEASES 55757 \| UGGT2 \| DISEASES 4943 \| TBC1D25 \| DISEASES 1471 \| CST3 \| DISEASES 116085 \| SLC22A12 \| DISEASES 8029 \| CUBN \| DISEASES 127262 \| TPRG1L \| DISEASES 353 \| APRT \| DISEASES 79823 \| CAMKMT \| DISEASES 3980 \| LIG3 \| DISEASES 9445 \| ITM2B \| DISEASES 54363 \| HAO1 \| DISEASES 9468 \| PCYT1B \| DISEASES 7498 \| XDH \| DISEASES 9365 \| KL \| DISEASES 145781 \| GCOM1 \| DISEASES 1183 \| CLCN4 \| DISEASES 6557 \| SLC12A1 \| DISEASES 1667 \| DEFA1 \| DISEASES 728358 \| DEFA1B \| DISEASES 1186 \| CLCN7 \| DISEASES 3758 \| KCNJ1 \| DISEASES 2591 \| GALNT3 \| DISEASES 91433 \| RCCD1 \| DISEASES 79001 \| VKORC1 \| DISEASES 6696 \| SPP1 \| DISEASES 65010 \| SLC26A6 \| DISEASES 5744 \| PTHLH \| DISEASES 10786 \| SLC17A3 \| DISEASES 152330 \| CNTN4 \| DISEASES 54890 \| ALKBH5 \| DISEASES 728441 \| GGT2 \| DISEASES 10636 \| RGS14 \| DISEASES 22891 \| ZNF365 \| DISEASES 85376 \| RIMBP3 \| DISEASES 9058 \| SLC13A2 \| DISEASES 8671 \| SLC4A4 \| DISEASES 197 \| AHSG \| DISEASES 25801 \| GCA \| DISEASES 960 \| CD44 \| DISEASES 83463 \| MXD3 \| DISEASES 6559 \| SLC12A3 \| DISEASES 2821 \| GPI \| DISEASES 7266 \| DNAJC7 \| DISEASES 2876 \| GPX1 \| DISEASES 9351 \| SLC9A3R2 \| DISEASES 1132 \| CHRM4 \| DISEASES 22930 \| RAB3GAP1 \| DISEASES 64283 \| ARHGEF28 \| DISEASES 10046 \| MAMLD1 \| DISEASES 54659 \| UGT1A3 \| DISEASES 846 \| CASR \| DISEASES 7033 \| TFF3 \| DISEASES 7178 \| TPT1 \| DISEASES 5833 \| PCYT2 \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 8437 \| RASAL1 \| DISEASES 9990 \| SLC12A6 \| DISEASES 567 \| B2M \| DISEASES 388588 \| SMIM1 \| DISEASES 54757 \| FAM20A \| DISEASES 692084 \| SNORD13 \| DISEASES 9299 \| SNORD30 \| DISEASES
Locus	(Waiting for update.)

Disease ID	282
Disease	nephrolithiasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:46) HP:0002150 \| Hypercalcinuria \| 6 HP:0000121 \| Nephrocalcinosis \| 4 HP:0000083 \| Renal insufficiency \| 4 HP:0008200 \| Primary hyperparathyroidism \| 4 HP:0012531 \| Pain \| 4 HP:0000822 \| Hypertension \| 3 HP:0000010 \| Frequent urinary tract infections \| 3 HP:0000843 \| Hyperparathyroidism \| 3 HP:0001513 \| Obesity \| 3 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0000093 \| Proteinuria \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0030157 \| Flank pain \| 2 HP:0000855 \| Insulin resistance \| 2 HP:0000790 \| Hematuria \| 2 HP:0000819 \| Diabetes mellitus \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0000123 \| Nephritis \| 1 HP:0001997 \| Gout \| 1 HP:0001941 \| acidemia \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002748 \| Rickets \| 1 HP:0002149 \| Hyperuricemia \| 1 HP:0003159 \| Hyperoxaluria \| 1 HP:0008341 \| Renal tubular acidosis, type I \| 1 HP:0000126 \| Hydronephrosis \| 1 HP:0000081 \| Double urinary collecting systems on intravenous pyelography \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0000854 \| Thyroid adenoma \| 1 HP:0003355 \| Aminoaciduria \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0004912 \| Hypophosphatemic rickets \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000085 \| Horseshoe kidney \| 1 HP:0010934 \| Increased urinary xanthine \| 1 HP:0000086 \| Ectopic kidney \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0003537 \| Low blood uric acid levels \| 1 HP:0100806 \| Sepsis \| 1 HP:0002897 \| Parathyroid adenoma \| 1 HP:0100033 \| Tic disorder \| 1

Disease ID	282
Disease	nephrolithiasis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:14) C0020438 \| hypercalciuria \| 6 C0030193 \| pain \| 4 C0009450 \| infection \| 4 C0221002 \| primary hyperparathyroidism \| 4 C0035078 \| renal failure \| 3 C0042029 \| urinary tract infection \| 3 C0020502 \| hyperparathyroidism \| 3 C0020538 \| hypertension \| 3 C0022681 \| medullary sponge kidney \| 3 C0232488 \| colic \| 2 C0025517 \| metabolic disorders \| 1 C0152169 \| renal colic \| 1 C0016169 \| fistula \| 1 C0020295 \| hydronephrosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:47)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1000597	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	NA	7	30897563	T	C
rs1000597	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	NA	7	30897563	T	C
rs1000597	22396660	10636	RGS14	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122638474	2012	NA	7	30897563	T	C
rs1000597	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	NA	7	30897563	T	C
rs1000597	22396660	84182	FAM188B	umls:C0392525	GAD	[A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.]	0.002367032	2012	NA	7	30897563	T	C
rs1000597	22396660	160851	DGKH	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122909916	2012	NA	7	30897563	T	C
rs1000597	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	NA	7	30897563	T	C
rs1170155	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	DGKH	13	42128575	C	T
rs1170155	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	DGKH	13	42128575	C	T
rs1170155	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42128575	C	T
rs1170155	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42128575	C	T
rs11746443	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	RGS14	5	177371305	G	A
rs11746443	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	RGS14	5	177371305	G	A
rs11746443	22396660	10636	RGS14	umls:C0392525	GAD	[Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; Pa=a8.51A10a>>A1A2, odds ratio (OR)a=a1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; Pa=a2.16A10a>>A1a', ORa=a1.22), and DGKH on 13q14.1 (rs4142110; Pa=a4.62A10a>>a1, ORa=a1.14).]	0.122638474	2012	RGS14	5	177371305	G	A
rs11746443	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	RGS14	5	177371305	G	A
rs11746443	22396660	10636	RGS14	umls:C0392525	GWASCAT	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122638474	2012	RGS14	5	177371305	G	A
rs11746443	22396660	10636	RGS14	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122638474	2012	RGS14	5	177371305	G	A
rs11746443	22396660	160851	DGKH	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122909916	2012	RGS14	5	177371305	G	A
rs11746443	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	RGS14	5	177371305	G	A
rs12654812	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	RGS14	5	177367190	G	A
rs12654812	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	RGS14	5	177367190	G	A
rs12654812	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	RGS14	5	177367190	G	A
rs12654812	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	RGS14	5	177367190	G	A
rs12669187	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	FAM188B;INMT-FAM188B	7	30875863	G	A
rs12669187	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	FAM188B;INMT-FAM188B	7	30875863	G	A
rs12669187	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	FAM188B;INMT-FAM188B	7	30875863	G	A
rs12669187	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	FAM188B;INMT-FAM188B	7	30875863	G	A
rs17251221	21966463	846	CASR	umls:C0392525	BeFree	A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.	0.001900093	2011	CASR	3	122274400	A	G
rs219780	19561606	23562	CLDN14	umls:C0022650	GAD	[Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density.]	0.243181358	2009	CLDN14;LOC105369301	21	36461009	C	T
rs219780	26554238	5741	PTH	umls:C0392525	BeFree	The C allele of the rs219780 SNP (single nucleotide polymorphism) of CLDN14 has been associated with renal lithiasis, high levels of parathormone (PTH), and with low bone mineral density (BMD) in healthy women.	0.001900093	2015	CLDN14;LOC105369301	21	36461009	C	T
rs219780	19561606	23562	CLDN14	umls:C0022650	GWASCAT	Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density.	0.243181358	2009	CLDN14;LOC105369301	21	36461009	C	T
rs219780	26554238	23562	CLDN14	umls:C0392525	BeFree	Our aim is to study the relationship between rs219780 SNP of CLDN14 and renal lithiasis, fractures, and BMD in patients with primary hyperparathyroidism (PHPT).	0.000542884	2015	CLDN14;LOC105369301	21	36461009	C	T
rs34116584	24344980	189	AGXT	umls:C0022650	BeFree	The AGT Pro11Leu polymorphism in the alanine:glyoxylate aminotransferase (AGT) enzyme has been suggested as possibly playing a role in the pathogenesis of idiopathic calcium oxalate kidney stones.	0.001628651	2014	AGXT;LOC105373969	2	240868897	C	A,G,T
rs4142110	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42180386	T	C
rs4142110	22396660	160851	DGKH	umls:C0392525	GWASCAT	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122909916	2012	DGKH	13	42180386	T	C
rs4142110	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42180386	T	C
rs4142110	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	DGKH	13	42180386	T	C
rs4142110	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	DGKH	13	42180386	T	C
rs4142110	22396660	160851	DGKH	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122909916	2012	DGKH	13	42180386	T	C
rs4142110	22396660	10636	RGS14	umls:C0392525	BeFree	Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14).	0.122638474	2012	DGKH	13	42180386	T	C
rs4142110	22396660	160851	DGKH	umls:C0392525	GAD	[Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; Pa=a8.51A10a>>A1A2, odds ratio (OR)a=a1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; Pa=a2.16A10a>>A1a', ORa=a1.22), and DGKH on 13q14.1 (rs4142110; Pa=a4.62A10a>>a1, ORa=a1.14).]	0.122909916	2012	DGKH	13	42180386	T	C
rs4236480	26089600	56302	TRPV5	umls:C0392525	BeFree	A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients.	0.000271442	2015	TRPV5	7	142929454	T	C,A
rs5896	23029076	2147	F2	umls:C0022650	BeFree	Association between human prothrombin variant (T165M) and kidney stone disease.	0.003181358	2012	F2	11	46723453	C	T
rs7981733	23719187	358	AQP1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42115924	C	T
rs7981733	23719187	6569	SLC34A1	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000814326	2013	DGKH	13	42115924	C	T
rs7981733	23719187	160851	DGKH	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.122909916	2013	DGKH	13	42115924	C	T
rs7981733	23719187	345456	PFN3	umls:C0392525	BeFree	We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis.	0.000271442	2013	DGKH	13	42115924	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:154)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	111821777	rs4838896	T	C	rs4838896	22396660	5.87E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C,T	NA
1	111829797	rs12401767	G	A	rs12401767	22396660	3.36E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
1	111832291	rs3806446	T	C	rs3806446	22396660	2.35E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
1	162187715	rs16858527	A	G	rs16858527	22396660	5.84E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NOS1AP
1	162193738	rs16858695	C	T	rs16858695	22396660	5.45E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NOS1AP
1	203472941	rs2279127	A	G	rs2279127	22396660	5.28E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	OPTC
2	12279879	rs916522	C	A	rs916522	22396660	6.82E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	19625636	rs2198161	G	A	rs2198161	22396660	6.86E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	19625818	rs703297	C	T	rs703297	22396660	4.11E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	27910706	rs13023094	A	C	rs13023094	22396660	7.05E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	SLC4A1AP
2	139258603	rs13405108	G	A	rs13405108	22396660	6.29E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	170175109	rs861239	T	C	rs861239	22396660	4.87E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	LRP2
2	170175334	rs2229263	T	C	rs2229263	22396660	4.51E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	LRP2
2	170196990	rs10930352	T	C	rs10930352	22396660	4.59E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	LRP2
2	234726058	rs13015369	G	T	rs13015369	22396660	4.02E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	HEATR7B1
3	28871595	rs11926073	G	A	rs11926073	22396660	1.74E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
5	33828203	rs977842	G	A	rs977842	22396660	4.62E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	ADAMTS12
5	106116276	rs13156926	G	T	rs13156926	22396660	9.58E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
5	176784439	rs4976688	T	C	rs4976688	22396660	3.45E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
5	176784512	rs4075958	G	A	rs4075958	22396660	3.74E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
5	176794191	rs12654812	G	A	rs12654812	22396660	1.98E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	RGS14
5	176797343	rs4074995	G	A	rs4074995	22396660	1.95E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	RGS14
5	176798306	rs11746443	G	A	rs11746443	22396660	9.00E-12	NA	1.19	[1.13-1.24]	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	RGS14
5	176801131	rs10866705	C	A	rs10866705	22396660	7.43E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
5	176806636	rs35716097	C	T	rs35716097	22396660	1.98E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
5	176813404	rs3812036	C	T	rs3812036	22396660	1.48E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	SLC34A1
5	176822512	rs6862195	G	T	rs6862195	22396660	9.41E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	SLC34A1
5	176827815	rs4976691	C	G	rs4976691	22396660	9.50E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	PFN3
6	24967294	rs400592	C	G	rs400592	21283782	5.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	24979164	rs7773555	T	A	rs7773555	21283782	7.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
6	25010999	rs10946741	G	A	rs10946741	21283782	9.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	25407778	rs12173289	A	G	rs12173289	21283782	1.20E-06	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
6	25409785	rs6912426	G	A	rs6912426	21283782	1.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	42039572	rs7763360	A	G	rs7763360	22396660	2.21E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	TAF8
6	43806609	rs881858	G	A	rs881858	22396660	9.90E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
6	106836299	rs2749083	A	C	rs2749083	22396660	3.00E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
6	136944063	rs3765258	A	G	rs3765258	22396660	7.38E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	MAP3K5
7	30879317	rs12672329	A	G	rs12672329	22396660	8.47E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	FAM188B
7	30886500	rs7791980	G	A	rs7791980	22396660	2.95E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	FAM188B
7	30886563	rs7792019	G	C	rs7792019	22396660	2.95E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	FAM188B
7	30887150	rs12673857	A	G	rs12673857	22396660	1.47E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	FAM188B
7	30887230	rs6959949	G	A	rs6959949	22396660	3.93E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	FAM188B
7	30887782	rs1468313	T	G	rs1468313	22396660	4.19E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	FAM188B
7	30890329	rs12671536	C	T	rs12671536	22396660	3.16E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	FAM188B
7	30895840	rs12670734	A	G	rs12670734	22396660	3.08E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	FAM188B
7	30899543	rs12674155	C	T	rs12674155	22396660	2.47E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	FAM188B
7	30915478	rs12669187	G	A	rs12669187	22396660	1.04E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	FAM188B
7	30934659	rs4723021	C	T	rs4723021	22396660	1.61E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
7	30937178	rs1000597	T	C	rs1000597	22396660	2.00E-14	NA	1.22	[1.16-1.29]	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G,A	NA
7	38046212	rs952368	C	T	rs952368	22396660	1.08E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
7	142137119	rs2040369	T	C	rs2040369	22396660	5.14E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
8	37409288	rs7003946	C	T	rs7003946	22396660	4.73E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
8	92406021	rs16912805	C	T	rs16912805	22396660	4.43E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	SLC26A7
10	2993191	rs11251596	C	T	rs11251596	22396660	2.05E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
10	72511528	rs12784847	G	A	rs12784847	21283782	7.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
10	72522189	rs3740434	A	G	rs3740434	21283782	8.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	72528564	rs11591930	T	A	rs11591930	21283782	3.00E-05	NA	NA	NA	73 Sardinian cases; 92 Sardinian controls	Sardinian(165)	ALL(165)	EUR(165)	ALL(165)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	124431063	rs2177831	G	A	rs2177831	22396660	3.76E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
10	124456562	rs4980250	C	T	rs4980250	22396660	5.96E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
10	124488143	rs2901344	T	C	rs2901344	22396660	6.30E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
10	124491040	rs17104017	G	A	rs17104017	22396660	6.69E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
10	124504595	rs13376724	A	G	rs13376724	22396660	1.57E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
10	124506648	rs4980182	A	C	rs4980182	22396660	9.84E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
11	105498095	rs1445604	G	T	rs1445604	22396660	1.22E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	GRIA4
11	122403463	rs10502250	A	G	rs10502250	22396660	3.63E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
11	123770186	rs2315027	A	G	rs2315027	22396660	1.02E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G,A	NA
12	62406171	rs1732362	A	G	rs1732362	22396660	5.22E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	FAM19A2
12	97529985	rs11108836	G	A	rs11108836	22396660	3.68E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
12	97553106	rs11108857	T	C	rs11108857	22396660	5.97E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
12	97588017	rs2160427	C	T	rs2160427	22396660	2.21E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
12	98029100	rs1450997	T	C	rs1450997	22396660	9.31E-07	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
12	98032566	rs6538815	G	A	rs6538815	22396660	3.59E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
12	98038863	rs34552	A	G	rs34552	22396660	2.01E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
12	98054607	rs10735355	G	A	rs10735355	22396660	2.19E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
12	98061146	rs248812	C	A	rs248812	22396660	9.38E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
13	24631796	rs9511023	A	G	rs9511023	22396660	4.86E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
13	42590075	rs9562369	C	T	rs9562369	22396660	2.78E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
13	42642546	rs9566906	G	A	rs9566906	22396660	1.18E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42651002	rs9566910	G	A	rs9566910	22396660	2.08E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42656841	rs2253650	C	T	rs2253650	22396660	7.16E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42657148	rs4994103	C	T	rs4994103	22396660	1.17E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42659480	rs9562373	G	A	rs9562373	22396660	1.22E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42660006	rs1900413	A	G	rs1900413	22396660	1.22E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42663251	rs9525568	A	G	rs9525568	22396660	5.78E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42675493	rs1170191	A	G	rs1170191	22396660	1.16E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42677238	rs912875	A	C	rs912875	22396660	4.09E-07	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42678357	rs7984523	C	T	rs7984523	22396660	5.48E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42678971	rs1170188	A	G	rs1170188	22396660	1.13E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42679835	rs1170187	G	A	rs1170187	22396660	1.13E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42685379	rs9562377	A	G	rs9562377	22396660	4.22E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42687004	rs9566921	A	G	rs9566921	22396660	4.22E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42689853	rs585206	A	G	rs585206	22396660	1.75E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42690060	rs7981733	C	T	rs7981733	22396660	4.08E-07	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42692823	rs1177637	G	A	rs1177637	22396660	1.40E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42697807	rs1170169	G	C	rs1170169	22396660	1.42E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42699079	rs9315891	C	T	rs9315891	22396660	4.12E-07	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42699907	rs9566924	T	C	rs9566924	22396660	2.12E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42701739	rs670676	A	T	rs670676	22396660	5.17E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42701941	rs1170158	G	T	rs1170158	22396660	6.25E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42702711	rs1170155	C	T	rs1170155	22396660	1.15E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42704451	rs1750017	G	A	rs1750017	22396660	2.13E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42705808	rs1170178	T	C	rs1170178	22396660	1.60E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42708389	rs9566928	A	G	rs9566928	22396660	1.44E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42708655	rs682573	G	T	rs682573	22396660	1.97E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42710235	rs9533007	A	G	rs9533007	22396660	1.94E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42711224	rs12585075	C	T	rs12585075	22396660	1.97E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42712741	rs12876965	A	T	rs12876965	22396660	1.65E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42748558	rs17701966	T	A	rs17701966	22396660	1.38E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42754522	rs4142110	T	C	rs4142110	22396660	5.00E-09	NA	1.14	[1.09-1.19]	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42759971	rs12585267	A	C	rs12585267	22396660	1.93E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42762871	rs4598803	A	G	rs4598803	22396660	1.89E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42763140	rs2122247	G	A	rs2122247	22396660	1.90E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42767185	rs9566935	T	G	rs9566935	22396660	1.29E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42767706	rs10492438	C	A	rs10492438	22396660	1.90E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	DGKH
13	42768720	rs12584544	G	A	rs12584544	22396660	1.90E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42772222	rs17598799	C	G	rs17598799	22396660	4.00E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42776117	rs1170102	G	A	rs1170102	22396660	1.67E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
13	42777027	rs1170103	G	C	rs1170103	22396660	1.86E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42779694	rs1170109	G	T	rs1170109	22396660	2.50E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42780628	rs9562385	C	A	rs9562385	22396660	2.21E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42782887	rs9566939	C	A	rs9566939	22396660	9.21E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	DGKH
13	42787040	rs347413	G	A	rs347413	22396660	2.61E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	DGKH
13	42789366	rs347403	A	G	rs347403	22396660	1.10E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	DGKH
17	59444758	rs1990292	G	A	rs1990292	22396660	2.25E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	BCAS3
17	59450441	rs9905274	T	C	rs9905274	22396660	2.81E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	BCAS3
18	3086065	rs3765623	C	T	rs3765623	22396660	3.83E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	MYOM1
18	20664430	rs9807753	G	A	rs9807753	22396660	1.04E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
18	20672555	rs8098316	T	G	rs8098316	22396660	4.77E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	NA
18	20683093	rs6507498	T	C	rs6507498	22396660	4.55E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
18	20709123	rs8093542	A	C	rs8093542	22396660	3.21E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
18	20716805	rs4800451	C	T	rs4800451	22396660	3.30E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	CABLES1
18	20724328	rs4800148	G	A	rs4800148	22396660	6.35E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	CABLES1
18	20724810	rs7235010	G	A	rs7235010	22396660	7.59E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	CABLES1
18	20727611	rs4800452	C	T	rs4800452	22396660	7.74E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	CABLES1
18	20731930	rs4239436	A	G	rs4239436	22396660	4.97E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	CABLES1
18	55995721	rs4058287	A	G	rs4058287	22396660	9.29E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A,G	NEDD4L
19	4013389	rs7257356	C	T	rs7257356	22396660	7.34E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	PIAS4
19	4014065	rs8113562	G	A	rs8113562	22396660	5.12E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	PIAS4
19	14557821	rs3786654	A	G	rs3786654	22396660	3.30E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	PKN1
19	14573654	rs2420538	A	G	rs2420538	22396660	3.96E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	T	PKN1
19	17952930	rs867174	A	G	rs867174	22396660	2.75E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	JAK3
19	18004912	rs12327843	T	C	rs12327843	22396660	2.26E-06	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	SLC5A5
19	18517767	rs13344313	G	A	rs13344313	22396660	3.21E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
19	48531216	rs2560966	T	G	rs2560966	22396660	3.49E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
19	48543862	rs8105198	G	A	rs8105198	22396660	2.52E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	CABP5
20	2812772	rs6084184	A	G	rs6084184	22396660	6.67E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
20	52742590	rs17217119	A	G	rs17217119	22396660	7.85E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	A	NA
21	37794921	rs218634	G	A	rs218634	19561606	1.40E-06	NA	NA	NA	1,507 European ancestry cases; 34,033 European ancestry controls	European(35540)	ALL(35540)	EUR(35540)	ALL(35540)	Kidney stones	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D007669	Kidney Calculi	EFOID:0003845	kidney stone	Kidney disease	NA	NA	C	NA
21	37814114	rs2835349	T	C	rs2835349	22396660	6.33E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA
21	37832621	rs219781	G	T	rs219781	19561606	3.20E-08	NA	NA	NA	1,507 European ancestry cases; 34,033 European ancestry controls	European(35540)	ALL(35540)	EUR(35540)	ALL(35540)	Kidney stones	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D007669	Kidney Calculi	EFOID:0003845	kidney stone	Kidney disease	NA	NA	A	CLDN14
21	37833307	rs219780	C	T	rs219780	19561606	4.00E-12	NA	1.25	[1.17-1.33]	1,507 European ancestry cases; 34,033 European ancestry controls	European(35540)	ALL(35540)	EUR(35540)	ALL(35540)	Kidney stones	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D007669	Kidney Calculi	EFOID:0003845	kidney stone	Kidney disease	rs219780-C	NA	G	CLDN14
21	37834641	rs219778	A	G	rs219778	19561606	3.20E-08	NA	NA	NA	1,507 European ancestry cases; 34,033 European ancestry controls	European(35540)	ALL(35540)	EUR(35540)	ALL(35540)	Kidney stones	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D007669	Kidney Calculi	EFOID:0003845	kidney stone	Kidney disease	NA	NA	T	CLDN14
22	23742105	rs2003752	G	A	rs2003752	22396660	5.89E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	G	NA
22	23779822	rs5759802	C	T	rs5759802	22396660	1.51E-05	NA	NA	NA	904 Japanese ancestry cases; 7,471 Japanese ancestry controls	Japanese(8375)	ALL(8375)	ASN(8375)	ALL(8375)	Nephrolithiasis	HPOID:0000787	Nephrolithiasis	DOID:585	nephrolithiasis	D053040	Nephrolithiasis	EFOID:0004253	nephrolithiasis	Kidney disease	NA	Research Support, Non-U.S. Gov't	C	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:21)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022650	allopurinol	D000493	315-30-0	kidney calculi	MESH:D007669	therapeutic	1682578
C0022650	calcitriol	D002117	32222-06-3	kidney calculi	MESH:D007669	marker/mechanism	7571189
C0022650	felbamate	C047360	25451-15-4	kidney calculi	MESH:D007669	marker/mechanism	9848129
C0022650	glutathione	D005978	70-18-8	kidney calculi	MESH:D007669	marker/mechanism	24360074
C0022650	indinavir	D019469	150378-17-9	kidney calculi	MESH:D007669	marker/mechanism	10081842
C0022650	nelfinavir	D019888	159989-64-7	kidney calculi	MESH:D007669	marker/mechanism	11832739
C0022650	phenytoin	D010672	57-41-0	kidney calculi	MESH:D007669	marker/mechanism	18620500
C0022650	pyrimethamine	D011739	58-14-0	kidney calculi	MESH:D007669	marker/mechanism	8773165
C0022650	streptozocin	D013311	18883-66-4	kidney calculi	MESH:D007669	marker/mechanism	2827466
C0022650	sulfadiazine	D013411	68-35-9	kidney calculi	MESH:D007669	marker/mechanism	10939760
C0022650	triamterene	D014223	396-01-0	kidney calculi	MESH:D007669	marker/mechanism	2321916
C0022650	vitamin e	D014810	1406-18-4	kidney calculi	MESH:D007669	therapeutic	8112761
C0022650	calcitriol	D002117	32222-06-3	nephrolithiasis	MESH:D053040	marker/mechanism	20578617
C0022650	indinavir	D019469	150378-17-9	nephrolithiasis	MESH:D053040	marker/mechanism	10476752
C0022650	potassium citrate	D019357	6100/5/6	nephrolithiasis	MESH:D053040	therapeutic	11475849
C0022650	ribavirin	D012254	36791-04-5	nephrolithiasis	MESH:D053040	marker/mechanism	11330434
C0022650	ritonavir	D019438	-	nephrolithiasis	MESH:D053040	marker/mechanism	12473836
C0022650	sulfadiazine	D013411	68-35-9	nephrolithiasis	MESH:D053040	marker/mechanism	15025231
C0022650	topiramate	C052342	97240-79-4	nephrolithiasis	MESH:D053040	marker/mechanism	12042105
C0022650	triamterene	D014223	396-01-0	nephrolithiasis	MESH:D053040	marker/mechanism	2231920
C0022650	zidovudine	D015215	30516-87-1	nephrolithiasis	MESH:D053040	marker/mechanism	10877738

FDA approved drug and dosage information(Total Drugs:19)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D053040	calcijex	calcitriol	0.001MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D053040	norvir	ritonavir	80MG/ML	SOLUTION;ORAL	Prescription	None	Yes	Yes
MESH:D053040	norvir	ritonavir	100MG	CAPSULE;ORAL	Discontinued	None	No	No
MESH:D053040	norvir	ritonavir	100MG	CAPSULE;ORAL	Prescription	None	Yes	Yes
MESH:D053040	norvir	ritonavir	100MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	retrovir	zidovudine	100MG	CAPSULE;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	retrovir	zidovudine	50MG/5ML	SYRUP;ORAL	Prescription	AA	Yes	Yes
MESH:D053040	retrovir	zidovudine	10MG/ML	INJECTABLE;INJECTION	Prescription	AP	Yes	Yes
MESH:D053040	retrovir	zidovudine	200MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D053040	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D053040	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D053040	topamax	topiramate	100MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	topamax	topiramate	15MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D053040	topamax	topiramate	100MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	topamax	topiramate	15MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D053040	topamax	topiramate	100MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	topamax	topiramate	15MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D053040	topamax	topiramate	100MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D053040	topamax	topiramate	15MG	CAPSULE;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:19)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D053040	11/16/2001	calcijex	calcitriol	Management of hypocalcemia in patients undergoing chronic renal dialysis	The safety and effectiveness of calcitriol was examined in a double-blind placebo-controlled trial of 35 pediatric patients (13-18 years of age) with end-stage renal disease and on dialysis. The primary efficacy endpoint favored the calcitriol-treated versus the placebo-treated patients Transient hypercalcemia was seen in 1 of 16 calcitriol-treated patients; 6 of 16 (38%) calcitriol-treated patients and 2 of 19 (11%) placebo-treated patients had Ca x P >75	Labeling	B	-	-	-	Abbott	02/16/2001	FALSE'
MESH:D053040	6/10/2005	norvir	ritonavir	Treatment of HIV-infection in combination with other antiretroviral agents	Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters	Labeling	B	-	-	-	Abbott	06/14/2005	FALSE'
MESH:D053040	6/10/2005	norvir	ritonavir	Treatment of HIV-infection in combination with other antiretroviral agents	Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters	Labeling	B	-	-	-	Abbott	06/14/2005	FALSE'
MESH:D053040	6/10/2005	norvir	ritonavir	Treatment of HIV-infection in combination with other antiretroviral agents	Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters	Labeling	B	-	-	-	Abbott	06/14/2005	FALSE'
MESH:D053040	6/10/2005	norvir	ritonavir	Treatment of HIV-infection in combination with other antiretroviral agents	Extended age range from 2 years down to 1 month AE profile in the pediatric population was similar to that for adults Information on dose and PK parameters	Labeling	B	-	-	-	Abbott	06/14/2005	FALSE'
MESH:D053040	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	09/19/2008	retrovir syrup, capsules and tablets	zidovudine	Used in combination with 18 other antiretroviral agents for the treatment of HIV-1 infection	Dosing and administration information provided to children 6 weeks to less than 18 years of age Macrocytosis was reported in the majority of pediatric patients receiving Retrovir 180 mg/m2 every 6 hours in open-label studies New dosing regimen	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D053040	12/22/2009	topamax	topiramate	Migraine Prophylaxis	Safety and effectiveness for migraine prevention in pediatric patients have not been established Dose-related increased shift in serum creatinine in adolescent patients occurred in a clinical study Information added to Warnings and Precautions and Pediatric Use	Labeling	-	P	-	-	Ortho-McNeil-Janssen	-	FALSE'
MESH:D053040	12/22/2009	topamax	topiramate	Migraine Prophylaxis	Safety and effectiveness for migraine prevention in pediatric patients have not been established Dose-related increased shift in serum creatinine in adolescent patients occurred in a clinical study Information added to Warnings and Precautions and Pediatric Use	Labeling	-	P	-	-	Ortho-McNeil-Janssen	-	FALSE'
MESH:D053040	12/22/2009	topamax	topiramate	Adjunctive Treatment for Partial Onset Epilepsy in Infants and Toddlers 1 to 24 months	Effectiveness was not demonstrated as adjunctive therapy in a randomized, double-blind trial in infants/toddlers 1 to 24 months of age with refractory partial onset seizures Trials in infants/toddlers 1 to 24 months suggested some adverse reactions/toxicities not previously observed in older pediatric patients and adults; i.e, growth/length retardation, certain clinical laboratory abnormalities, and other adverse reactions/toxicities that occurred with a greater frequency and/or greater severity than had been recognized previously from studies in older pediatric patients or adults for various indications. Information added to Warnings and Precautions and Pediatric Use	Labeling	B	-	-	-	Ortho-McNeil-Janssen	07/24/2008	FALSE'
MESH:D053040	12/22/2009	topamax	topiramate	Adjunctive Treatment for Partial Onset Epilepsy in Infants and Toddlers 1 to 24 months	Effectiveness was not demonstrated as adjunctive therapy in a randomized, double-blind trial in infants/toddlers 1 to 24 months of age with refractory partial onset seizures Trials in infants/toddlers 1 to 24 months suggested some adverse reactions/toxicities not previously observed in older pediatric patients and adults; i.e, growth/length retardation, certain clinical laboratory abnormalities, and other adverse reactions/toxicities that occurred with a greater frequency and/or greater severity than had been recognized previously from studies in older pediatric patients or adults for various indications. Information added to Warnings and Precautions and Pediatric Use	Labeling	B	-	-	-	Ortho-McNeil-Janssen	07/24/2008	FALSE'
MESH:D053040	07/15/2011	topamax	topiramate	Monotherapy for partial onset or primary generalized tonic-clonic seizures	Expanded age range down to 2 years; previously approved for monotherapy for partial onset or primary generalized tonic-clonic seizures in patients10 years and older Information on weight based dosing in 2 to < 10 yearsPostmarketing study	Labeling	-	P	-	-	Janssen	-	FALSE'
MESH:D053040	07/15/2011	topamax	topiramate	Monotherapy for partial onset or primary generalized tonic-clonic seizures	Expanded age range down to 2 years; previously approved for monotherapy for partial onset or primary generalized tonic-clonic seizures in patients10 years and older Information on weight based dosing in 2 to < 10 yearsPostmarketing study	Labeling	-	P	-	-	Janssen	-	FALSE'
MESH:D053040	03/28/2014	topamax	topiramate	Prophylaxis of migraine headache	Approved for use in pediatric patients 12 years and older Safety and effectiveness in pediatric patients less than12 years have not been established for the prophylaxis treatment of migraine headache In the adolescent migraine trials (12 to 17 years), the most commonly observed adverse reactions were: paresthesia, upper respiratory tract infection, anorexia, and abdominal pain The most common cognitive adverse reaction in pooled double-blind studies in adolescent patients 12 to 17 years was difficulty with concentration/attention Markedly abnormally low serum bicarbonate values indicative of metabolic acidosis were reported in topiramate-treated adolescent migraine patients In topiramate-treated patients 12 to 17 years compared to placebo-treated patients, abnormally increased results were more frequent for creatinine, BUN, uric acid, chloride, ammonia, total protein, and platelets. Abnormally decreased results were observed with topiramate vs placebo treatment for phosphorus and bicarbonate Notable changes (increases and decreases) from baseline in systolic blood pressure, diastolic blood pressure, and pulse were observed more commonly in adolescents treated with topiramate compared to adolescents treated with placebo Information on dosing, adverse reactions, laboratory abnormalities, and clinical trials Postmarketing study	Labeling	-	P	-	-	Janssen	-	FALSE'
MESH:D053040	03/28/2014	topamax	topiramate	Prophylaxis of migraine headache	Approved for use in pediatric patients 12 years and older Safety and effectiveness in pediatric patients less than12 years have not been established for the prophylaxis treatment of migraine headache In the adolescent migraine trials (12 to 17 years), the most commonly observed adverse reactions were: paresthesia, upper respiratory tract infection, anorexia, and abdominal pain The most common cognitive adverse reaction in pooled double-blind studies in adolescent patients 12 to 17 years was difficulty with concentration/attention Markedly abnormally low serum bicarbonate values indicative of metabolic acidosis were reported in topiramate-treated adolescent migraine patients In topiramate-treated patients 12 to 17 years compared to placebo-treated patients, abnormally increased results were more frequent for creatinine, BUN, uric acid, chloride, ammonia, total protein, and platelets. Abnormally decreased results were observed with topiramate vs placebo treatment for phosphorus and bicarbonate Notable changes (increases and decreases) from baseline in systolic blood pressure, diastolic blood pressure, and pulse were observed more commonly in adolescents treated with topiramate compared to adolescents treated with placebo Information on dosing, adverse reactions, laboratory abnormalities, and clinical trials Postmarketing study	Labeling	-	P	-	-	Janssen	-	FALSE'