PedAM

Pediatric Disease Annotations & Medicines


	necrotizing fasciitis

Disease ID	429
Disease	necrotizing fasciitis
Definition	A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.
Synonym	fasciitides, necrotizing fasciitis necrotising fasciitis necrotize fasciitis necrotizing fasciitis, necrotizing fasciitis, necrotizing [disease/finding] fascitides, necrotizing fascitis necrotizing fascitis, necrotizing gangrene, hemolytic streptococcus necrotising cellulitis necrotising erysipelas necrotising fasciitis necrotising fasciitis (disorder) necrotising myositis necrotizing cellulitis necrotizing erysipelas necrotizing fasciitides necrotizing fasciitis (disorder) necrotizing fascitides necrotizing fascitis necrotizing myositis streptococcal gangrene
DOID	DOID:9602
ICD10	ICD10CM:M72.6
UMLS	C0238124
MeSH	D019115
SNOMED-CT	SNOMEDCT_US_2016_09_01:52486002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:52) C0025064 \| mediastinitis \| 3 C0032285 \| pneumoniae \| 2 C0003873 \| rheumatoid arthritis \| 2 C0024081 \| ludwig's angina \| 2 C0007642 \| cellulitis \| 2 C0007113 \| rectal cancer \| 2 C0029443 \| osteomyelitis \| 2 C0600327 \| toxic shock syndrome \| 2 C0003864 \| arthritis \| 2 C0278554 \| recurrent rectal cancer \| 1 C0015029 \| ethmoid sinusitis \| 1 C0006142 \| breast cancer \| 1 C0015645 \| fasciitis \| 1 C0334277 \| metastatic adenocarcinoma \| 1 C0011849 \| diabetes mellitus \| 1 C0021400 \| influenza \| 1 C0025289 \| meningitis \| 1 C0409974 \| lupus erythematosus \| 1 C0023418 \| leukemia \| 1 C0001418 \| adenocarcinoma \| 1 C0030805 \| pemphigoid \| 1 C0021845 \| bowel perforation \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0019196 \| hepatitis c \| 1 C0034150 \| purpura \| 1 C0398623 \| thrombophilia \| 1 C0013990 \| emphysema \| 1 C0023895 \| liver disease \| 1 C0023890 \| liver cirrhosis \| 1 C0040053 \| thrombosis \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0009492 \| compartment syndrome \| 1 C0002874 \| aplastic anemia \| 1 C0149507 \| orbital cellulitis \| 1 C0019112 \| hemorrhoids \| 1 C0008049 \| varicella \| 1 C0029408 \| osteoarthritis \| 1 C0600327 \| toxic-shock syndrome \| 1 C0030805 \| bullous pemphigoid \| 1 C0003177 \| cutaneous anthrax \| 1 C0011847 \| diabetes \| 1 C0003874 \| septic arthritis \| 1 C0011127 \| pressure ulcers \| 1 C0004623 \| bacterial infection \| 1 C0010414 \| cryptococcosis \| 1 C0034888 \| rectal prolapse \| 1 C0019158 \| hepatitis \| 1 C0008049 \| varicella infection \| 1 C0017105 \| gas gangrene \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0026946 \| fungal infection \| 1 C0520459 \| necrotizing enterocolitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:99) 266 \| AMELY \| DISEASES 158 \| ADSL \| DISEASES 1457 \| CSNK2A1 \| DISEASES 5961 \| PRPH2 \| DISEASES 566 \| AZU1 \| DISEASES 80218 \| NAA50 \| DISEASES 5335 \| PLCG1 \| DISEASES 718 \| C3 \| DISEASES 6217 \| RPS16 \| DISEASES 27112 \| FAM155B \| DISEASES 2161 \| F12 \| DISEASES 8431 \| NR0B2 \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 11019 \| LIAS \| DISEASES 9172 \| MYOM2 \| DISEASES 4591 \| TRIM37 \| DISEASES 443 \| ASPA \| DISEASES 3553 \| IL1B \| DISEASES 26273 \| FBXO3 \| DISEASES 5286 \| PIK3C2A \| DISEASES 150094 \| SIK1 \| DISEASES 710 \| SERPING1 \| DISEASES 1737 \| DLAT \| DISEASES 3606 \| IL18 \| DISEASES 26040 \| SETBP1 \| DISEASES 55079 \| FEZF2 \| DISEASES 8365 \| HIST1H4H \| DISEASES 213 \| ALB \| DISEASES 327 \| APEH \| DISEASES 5267 \| SERPINA4 \| DISEASES 90678 \| LRSAM1 \| DISEASES 3816 \| KLK1 \| DISEASES 2147 \| F2 \| DISEASES 10290 \| SPEG \| DISEASES 4179 \| CD46 \| DISEASES 2629 \| GBA \| DISEASES 5551 \| PRF1 \| DISEASES 55511 \| SAGE1 \| DISEASES 3052 \| HCCS \| DISEASES 51218 \| GLRX5 \| DISEASES 2689 \| GH2 \| DISEASES 5104 \| SERPINA5 \| DISEASES 2152 \| F3 \| DISEASES 25870 \| SUMF2 \| DISEASES 8360 \| HIST1H4D \| DISEASES 4771 \| NF2 \| DISEASES 6218 \| RPS17 \| DISEASES 8294 \| HIST1H4I \| DISEASES 8363 \| HIST1H4J \| DISEASES 8368 \| HIST1H4L \| DISEASES 273 \| AMPH \| DISEASES 135250 \| RAET1E \| DISEASES 8362 \| HIST1H4K \| DISEASES 121504 \| HIST4H4 \| DISEASES 8359 \| HIST1H4A \| DISEASES 3164 \| NR4A1 \| DISEASES 8367 \| HIST1H4E \| DISEASES 58484 \| NLRC4 \| DISEASES 56259 \| CTNNBL1 \| DISEASES 1660 \| DHX9 \| DISEASES 462 \| SERPINC1 \| DISEASES 55811 \| ADCY10 \| DISEASES 3645 \| INSRR \| DISEASES 1755 \| DMBT1 \| DISEASES 554313 \| HIST2H4B \| DISEASES 8370 \| HIST2H4A \| DISEASES 6491 \| STIL \| DISEASES 8473 \| OGT \| DISEASES 7099 \| TLR4 \| DISEASES 23569 \| PADI4 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 8366 \| HIST1H4B \| DISEASES 8361 \| HIST1H4F \| DISEASES 8364 \| HIST1H4C \| DISEASES 8434 \| RECK \| DISEASES 6197 \| RPS6KA3 \| DISEASES 2813 \| GP2 \| DISEASES 23475 \| QPRT \| DISEASES 899 \| CCNF \| DISEASES 23308 \| ICOSLG \| DISEASES 3778 \| KCNMA1 \| DISEASES 22848 \| AAK1 \| DISEASES 7124 \| TNF \| DISEASES 6635 \| SNRPE \| DISEASES 204801 \| NLRP11 \| DISEASES 389549 \| FEZF1 \| DISEASES 8801 \| SUCLG2 \| DISEASES 6949 \| TCOF1 \| DISEASES 6196 \| RPS6KA2 \| DISEASES 7033 \| TFF3 \| DISEASES 6195 \| RPS6KA1 \| DISEASES 6207 \| RPS13 \| DISEASES 83695 \| RHNO1 \| DISEASES 26150 \| RIBC2 \| DISEASES 820 \| CAMP \| DISEASES 100128252 \| ZNF667-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	429
Disease	necrotizing fasciitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:28) HP:0100806 \| Sepsis \| 3 HP:0100758 \| Gangrene \| 3 HP:0100658 \| Bacterial infection of skin \| 2 HP:0002754 \| Bone infection \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0001369 \| Arthritis \| 2 HP:0012115 \| Liver inflammation \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0030757 \| Dental abscess \| 1 HP:0100790 \| Hernia \| 1 HP:0001909 \| Leukemia \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0012531 \| Pain \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0002035 \| Rectal prolapse \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001287 \| Meningitis \| 1 HP:0000969 \| Dropsy \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0000979 \| Purpura \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0012399 \| Bedsore \| 1

Disease ID	429
Disease	necrotizing fasciitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2364133 \| infection C1704437 \| respiratory distress syndrome C0948600 \| organ failure C0343532 \| streptococcal toxic shock syndrome C0334533 \| arteriovenous malformation C0038395 \| streptococcal infection C0034067 \| emphysema C0023885 \| liver abscess
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0009450 \| infection \| 6 C0013990 \| emphysema \| 1 C0948600 \| organ failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002097	Emphysema	MP:0001835	abnormal antigen presentation;HP:0100026	Arteriovenous malformation

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0238124	bortezomib	D000069286	-	fasciitis, necrotizing	MESH:D019115	marker/mechanism	24671324

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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