PedAM

Pediatric Disease Annotations & Medicines


	myocarditis

Disease ID	725
Disease	myocarditis
Definition	Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Synonym	myocardial inflammation myocardial inflammation (finding) myocarditides myocarditis (disorder) myocarditis [disease/finding] myocarditis nos myocarditis nos (disorder) myocarditis, nos myocarditis, unspecified
DOID	DOID:820
ICD10	ICD10CM:I51.4
UMLS	C0027059
MeSH	D009205
SNOMED-CT	SNOMEDCT_US_2016_09_01:50920009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:122) C0018801 \| heart failure \| 33 C0021400 \| influenza \| 18 C0878544 \| cardiomyopathy \| 16 C0007193 \| dilated cardiomyopathy \| 16 C0027051 \| myocardial infarction \| 6 C0042769 \| viral infection \| 6 C0027051 \| myocardial infarct \| 6 C0018801 \| cardiac failure \| 5 C0042769 \| virus infection \| 5 C0023364 \| leptospirosis \| 5 C0031046 \| pericarditis \| 5 C0026691 \| kawasaki disease \| 5 C0034063 \| pulmonary edema \| 4 C0004245 \| atrioventricular block \| 4 C0014038 \| encephalitis \| 4 C1442837 \| myocardial necrosis \| 4 C0018802 \| congestive heart failure \| 4 C0032285 \| pneumonia \| 3 C0009324 \| ulcerative colitis \| 3 C0042769 \| viral infections \| 3 C0031039 \| pericardial effusion \| 3 C0009319 \| colitis \| 3 C0085253 \| adult-onset still's disease \| 3 C0042384 \| vasculitis \| 3 C0026896 \| myasthenia gravis \| 3 C0018799 \| heart disease \| 3 C0024537 \| vivax malaria \| 3 C0041234 \| chagas disease \| 2 C0349788 \| arrhythmogenic right ventricular dysplasia \| 2 C0041466 \| typhoid fever \| 2 C0014070 \| encephalomyelitis \| 2 C0027121 \| myositis \| 2 C0085655 \| polymyositis \| 2 C0155626 \| acute myocardial infarction \| 2 C0021831 \| bowel disease \| 2 C0025309 \| meningoencephalitis \| 2 C0020437 \| hypercalcemia \| 2 C0085399 \| ehrlichiosis \| 2 C0041296 \| tuberculosis \| 2 C0040053 \| thrombus \| 2 C0021390 \| inflammatory bowel disease \| 2 C0040100 \| thymoma \| 2 C0008728 \| churg-strauss syndrome \| 2 C0041466 \| typhoid \| 2 C0004245 \| av block \| 2 C0009782 \| connective tissue disease \| 1 C0019100 \| dengue hemorrhagic fever \| 1 C0398623 \| hypercoagulable state \| 1 C0019158 \| hepatitis \| 1 C0343939 \| trichosporonosis \| 1 C0007570 \| celiac disease \| 1 C0022667 \| renal medullary necrosis \| 1 C0040034 \| thrombocytopenia \| 1 C0040553 \| toxocara infection \| 1 C0878544 \| myocardial disease \| 1 C0010073 \| coronary spasm \| 1 C0079731 \| b-cell lymphoma \| 1 C0026934 \| mycoplasma \| 1 C0002871 \| anemia \| 1 C0024537 \| plasmodium vivax malaria \| 1 C0014118 \| endocarditis \| 1 C0030305 \| pancreatitis \| 1 C0025306 \| meningococcemia \| 1 C0085253 \| adult-onset still disease \| 1 C0275982 \| campylobacter enteritis \| 1 C0007113 \| rectal cancer \| 1 C0036472 \| scrub typhus \| 1 C0039483 \| giant cell arteritis \| 1 C0264716 \| chronic heart failure \| 1 C0008312 \| biliary cirrhosis \| 1 C0017152 \| gastritis \| 1 C0004096 \| asthma \| 1 C0032453 \| relapsing polychondritis \| 1 C0022660 \| acute renal failure \| 1 C0040053 \| thrombosis \| 1 C0041227 \| trypanosomiasis \| 1 C0152105 \| hypertensive heart disease \| 1 C0034065 \| pulmonary embolism \| 1 C0023241 \| legionella pneumonia \| 1 C0012546 \| diphtheria \| 1 C0043092 \| wegener granulomatosis \| 1 C0018799 \| cardiac disease \| 1 C0011644 \| scleroderma \| 1 C0519030 \| klebsiella pneumonia \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0018818 \| ventricular septal defect \| 1 C0949691 \| spondyloarthropathy \| 1 C0032285 \| pneumoniae \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0032371 \| polio \| 1 C0031350 \| pharyngitis \| 1 C0153500 \| heart ca \| 1 C0026266 \| mitral insufficiency \| 1 C0013264 \| duchenne muscular dystrophy (dmd) \| 1 C0026848 \| myopathies \| 1 C0039263 \| takayasu arteritis \| 1 C0241910 \| autoimmune hepatitis \| 1 C0011849 \| diabetes mellitus \| 1 C0085253 \| adult onset still's disease \| 1 C0026691 \| kawasaki's disease \| 1 C0034063 \| pulmonary oedema \| 1 C0085253 \| adult still's disease \| 1 C0011854 \| type 1 diabetes \| 1 C0037354 \| smallpox \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0007177 \| cardiac tamponade \| 1 C0278846 \| invasive thymoma \| 1 C0008148 \| chlamydia \| 1 C0025289 \| meningitis \| 1 C0013182 \| drug hypersensitivity \| 1 C0030312 \| pancytopenia \| 1 C1565489 \| renal insufficiency \| 1 C0040100 \| thymomas \| 1 C0026272 \| mixed connective tissue disease \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0021390 \| inflammatory bowel diseases \| 1 C0011847 \| diabetes \| 1 C0043202 \| wolff-parkinson-white syndrome \| 1 C0015974 \| periodic fever \| 1 C0018802 \| congestive cardiac failure \| 1 C1135191 \| systolic heart failure \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) TNF \| 7124 \| CTD_human SLC22A5 \| 6584 \| CTD_human CRP \| 1401 \| CTD_human SLC22A4 \| 6583 \| CTD_human SLC22A3 \| 6581 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:341) 10344 \| CCL26 \| DISEASES 5318 \| PKP2 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 30009 \| TBX21 \| DISEASES 3162 \| HMOX1 \| DISEASES 5721 \| PSME2 \| DISEASES 6640 \| SNTA1 \| DISEASES 51311 \| TLR8 \| DISEASES 7076 \| TIMP1 \| DISEASES 123876 \| ACSM2A \| DISEASES 4313 \| MMP2 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 1158 \| CKM \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 858 \| CAV2 \| DISEASES 6369 \| CCL24 \| DISEASES 727 \| C5 \| DISEASES 944 \| TNFSF8 \| DISEASES 79176 \| FBXL15 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 6783 \| SULT1E1 \| DISEASES 3558 \| IL2 \| DISEASES 81622 \| UNC93B1 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 1337 \| COX6A1 \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 6402 \| SELL \| DISEASES 471 \| ATIC \| DISEASES 7128 \| TNFAIP3 \| DISEASES 103910 \| MYL12B \| DISEASES 84272 \| YIPF4 \| DISEASES 4360 \| MRC1 \| DISEASES 27434 \| POLM \| DISEASES 56829 \| ZC3HAV1 \| DISEASES 10647 \| SCGB1D2 \| DISEASES 3659 \| IRF1 \| DISEASES 8744 \| TNFSF9 \| DISEASES 970 \| CD70 \| DISEASES 7429 \| VIL1 \| DISEASES 4189 \| DNAJB9 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 10053 \| AP1M2 \| DISEASES 1215 \| CMA1 \| DISEASES 3741 \| KCNA5 \| DISEASES 1160 \| CKMT2 \| DISEASES 3958 \| LGALS3 \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 29958 \| DMGDH \| DISEASES 22800 \| RRAS2 \| DISEASES 9695 \| EDEM1 \| DISEASES 187 \| APLNR \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 6741 \| SSB \| DISEASES 23316 \| CUX2 \| DISEASES 1975 \| EIF4B \| DISEASES 9172 \| MYOM2 \| DISEASES 57017 \| COQ9 \| DISEASES 5595 \| MAPK3 \| DISEASES 29904 \| EEF2K \| DISEASES 50507 \| NOX4 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 10994 \| ILVBL \| DISEASES 64135 \| IFIH1 \| DISEASES 6403 \| SELP \| DISEASES 941 \| CD80 \| DISEASES 6476 \| SI \| DISEASES 6774 \| STAT3 \| DISEASES 3383 \| ICAM1 \| DISEASES 27125 \| AFF4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 939 \| CD27 \| DISEASES 3687 \| ITGAX \| DISEASES 207 \| AKT1 \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 51143 \| DYNC1LI1 \| DISEASES 10330 \| CNPY2 \| DISEASES 185 \| AGTR1 \| DISEASES 3001 \| GZMA \| DISEASES 84651 \| SPINK7 \| DISEASES 90523 \| MLIP \| DISEASES 4794 \| NFKBIE \| DISEASES 55909 \| BIN3 \| DISEASES 3439 \| IFNA1 \| DISEASES 138151 \| NACC2 \| DISEASES 3606 \| IL18 \| DISEASES 7292 \| TNFSF4 \| DISEASES 2697 \| GJA1 \| DISEASES 925 \| CD8A \| DISEASES 136991 \| ASZ1 \| DISEASES 1525 \| CXADR \| DISEASES 2528 \| FUT6 \| DISEASES 1339 \| COX6A2 \| DISEASES 7547 \| ZIC3 \| DISEASES 5468 \| PPARG \| DISEASES 653361 \| NCF1 \| DISEASES 70 \| ACTC1 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 1173 \| AP2M1 \| DISEASES 6352 \| CCL5 \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 4724 \| NDUFS4 \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 1152 \| CKB \| DISEASES 6901 \| TAZ \| DISEASES 5896 \| RAG1 \| DISEASES 4314 \| MMP3 \| DISEASES 6778 \| STAT6 \| DISEASES 1159 \| CKMT1B \| DISEASES 22974 \| TPX2 \| DISEASES 915 \| CD3D \| DISEASES 4909 \| NTF4 \| DISEASES 53342 \| IL17D \| DISEASES 10251 \| SPRY3 \| DISEASES 1493 \| CTLA4 \| DISEASES 171558 \| PTCRA \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 3669 \| ISG20 \| DISEASES 56246 \| MRAP \| DISEASES 121391 \| KRT74 \| DISEASES 54205 \| CYCS \| DISEASES 5897 \| RAG2 \| DISEASES 3661 \| IRF3 \| DISEASES 8884 \| SLC5A6 \| DISEASES 836 \| CASP3 \| DISEASES 3728 \| JUP \| DISEASES 84868 \| HAVCR2 \| DISEASES 94033 \| FTMT \| DISEASES 64689 \| GORASP1 \| DISEASES 11238 \| CA5B \| DISEASES 1909 \| EDNRA \| DISEASES 6773 \| STAT2 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 4261 \| CIITA \| DISEASES 1604 \| CD55 \| DISEASES 50649 \| ARHGEF4 \| DISEASES 80381 \| CD276 \| DISEASES 9370 \| ADIPOQ \| DISEASES 23765 \| IL17RA \| DISEASES 6181 \| RPLP2 \| DISEASES 4723 \| NDUFV1 \| DISEASES 30832 \| ZNF354C \| DISEASES 3309 \| HSPA5 \| DISEASES 29895 \| MYLPF \| DISEASES 81857 \| MED25 \| DISEASES 2187 \| FANCB \| DISEASES 117608 \| ZNF354B \| DISEASES 4843 \| NOS2 \| DISEASES 3739 \| KCNA4 \| DISEASES 6331 \| SCN5A \| DISEASES 706 \| TSPO \| DISEASES 3665 \| IRF7 \| DISEASES 8651 \| SOCS1 \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 8338 \| HIST2H2AC \| DISEASES 340075 \| ARSI \| DISEASES 3751 \| KCND2 \| DISEASES 51363 \| CHST15 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 2626 \| GATA4 \| DISEASES 5133 \| PDCD1 \| DISEASES 8856 \| NR1I2 \| DISEASES 115286 \| SLC25A26 \| DISEASES 6940 \| ZNF354A \| DISEASES 55146 \| ZDHHC4 \| DISEASES 3932 \| LCK \| DISEASES 50615 \| IL21R \| DISEASES 1981 \| EIF4G1 \| DISEASES 6444 \| SGCD \| DISEASES 23583 \| SMUG1 \| DISEASES 9529 \| BAG5 \| DISEASES 7137 \| TNNI3 \| DISEASES 3146 \| HMGB1 \| DISEASES 165904 \| XIRP1 \| DISEASES 10746 \| MAP3K2 \| DISEASES 7273 \| TTN \| DISEASES 10252 \| SPRY1 \| DISEASES 3605 \| IL17A \| DISEASES 309 \| ANXA6 \| DISEASES 64218 \| SEMA4A \| DISEASES 140885 \| SIRPA \| DISEASES 64319 \| FBRS \| DISEASES 4624 \| MYH6 \| DISEASES 801 \| CALM1 \| DISEASES 60 \| ACTB \| DISEASES 1121 \| CHM \| DISEASES 7867 \| MAPKAPK3 \| DISEASES 841 \| CASP8 \| DISEASES 5699 \| PSMB10 \| DISEASES 9332 \| CD163 \| DISEASES 5094 \| PCBP2 \| DISEASES 4151 \| MB \| DISEASES 127343 \| DMBX1 \| DISEASES 5599 \| MAPK8 \| DISEASES 7707 \| ZNF148 \| DISEASES 54106 \| TLR9 \| DISEASES 8662 \| EIF3B \| DISEASES 6772 \| STAT1 \| DISEASES 4519 \| MT-CYB \| DISEASES 2475 \| MTOR \| DISEASES 4283 \| CXCL9 \| DISEASES 1756 \| DMD \| DISEASES 8678 \| BECN1 \| DISEASES 23038 \| WDTC1 \| DISEASES 6262 \| RYR2 \| DISEASES 58480 \| RHOU \| DISEASES 2058 \| EPRS \| DISEASES 7139 \| TNNT2 \| DISEASES 5788 \| PTPRC \| DISEASES 5743 \| PTGS2 \| DISEASES 4688 \| NCF2 \| DISEASES 356 \| FASLG \| DISEASES 6375 \| XCL1 \| DISEASES 1490 \| CTGF \| DISEASES 9447 \| AIM2 \| DISEASES 912 \| CD1D \| DISEASES 6280 \| S100A9 \| DISEASES 4942 \| OAT \| DISEASES 262 \| AMD1 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 153 \| ADRB1 \| DISEASES 282996 \| RBM20 \| DISEASES 1147 \| CHUK \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 51086 \| TNNI3K \| DISEASES 8790 \| FPGT \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 26027 \| ACOT11 \| DISEASES 10422 \| UBAC1 \| DISEASES 3434 \| IFIT1 \| DISEASES 1757 \| SARDH \| DISEASES 958 \| CD40 \| DISEASES 4318 \| MMP9 \| DISEASES 1025 \| CDK9 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 7295 \| TXN \| DISEASES 1896 \| EDA \| DISEASES 5698 \| PSMB9 \| DISEASES 83737 \| ITCH \| DISEASES 5696 \| PSMB8 \| DISEASES 1460 \| CSNK2B \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 5611 \| DNAJC3 \| DISEASES 3105 \| HLA-A \| DISEASES 10529 \| NEBL \| DISEASES 3604 \| TNFRSF9 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 8516 \| ITGA8 \| DISEASES 51567 \| TDP2 \| DISEASES 6354 \| CCL7 \| DISEASES 1536 \| CYBB \| DISEASES 2782 \| GNB1 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 1906 \| EDN1 \| DISEASES 9636 \| ISG15 \| DISEASES 1832 \| DSP \| DISEASES 23586 \| DDX58 \| DISEASES 2665 \| GDI2 \| DISEASES 3440 \| IFNA2 \| DISEASES 3443 \| IFNA6 \| DISEASES 3456 \| IFNB1 \| DISEASES 51284 \| TLR7 \| DISEASES 90865 \| IL33 \| DISEASES 29126 \| CD274 \| DISEASES 1497 \| CTNS \| DISEASES 116534 \| MRGPRE \| DISEASES 3660 \| IRF2 \| DISEASES 9560 \| CCL4L2 \| DISEASES 64400 \| AKTIP \| DISEASES 6696 \| SPP1 \| DISEASES 3965 \| LGALS9 \| DISEASES 2919 \| CXCL1 \| DISEASES 133746 \| JMY \| DISEASES 8887 \| TAX1BP1 \| DISEASES 10379 \| IRF9 \| DISEASES 6161 \| RPL32 \| DISEASES 3269 \| HRH1 \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 4626 \| MYH8 \| DISEASES 23308 \| ICOSLG \| DISEASES 11277 \| TREX1 \| DISEASES 3718 \| JAK3 \| DISEASES 279 \| AMY2A \| DISEASES 79094 \| CHAC1 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 4615 \| MYD88 \| DISEASES 57506 \| MAVS \| DISEASES 3594 \| IL12RB1 \| DISEASES 91833 \| WDR20 \| DISEASES 548596 \| CKMT1A \| DISEASES 3920 \| LAMP2 \| DISEASES 834 \| CASP1 \| DISEASES 83871 \| RAB34 \| DISEASES 3586 \| IL10 \| DISEASES 27042 \| DIEXF \| DISEASES 30816 \| ERVW-1 \| DISEASES 30819 \| KCNIP2 \| DISEASES 813 \| CALU \| DISEASES 56034 \| PDGFC \| DISEASES 51428 \| DDX41 \| DISEASES 100506742 \| CASP12 \| DISEASES 6224 \| RPS20 \| DISEASES 84000 \| TMPRSS13 \| DISEASES 488 \| ATP2A2 \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 146227 \| BEAN1 \| DISEASES 1649 \| DDIT3 \| DISEASES 7138 \| TNNT1 \| DISEASES 246734 \| NPCDR1 \| DISEASES 102723508 \| KANTR \| DISEASES 196475 \| RMST \| DISEASES 654321 \| SNORA75 \| DISEASES 692225 \| SNORD94 \| DISEASES
Locus	(Waiting for update.)

Disease ID	725
Disease	myocarditis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:70) HP:0001635 \| Congestive heart failure \| 39 HP:0001638 \| Cardiomyopathy \| 16 HP:0001644 \| Congestive cardiomyopathy \| 16 HP:0030149 \| Cardiovascular shock \| 15 HP:0011675 \| Arrhythmias \| 13 HP:0000969 \| Dropsy \| 11 HP:0001658 \| Myocardial infarction \| 6 HP:0001701 \| Pericarditis \| 5 HP:0100598 \| Pulmonary oedema \| 5 HP:0100749 \| Thoracic pain \| 5 HP:0012531 \| Pain \| 5 HP:0001678 \| Atrioventricular block \| 4 HP:0001700 \| Myocardial necrosis \| 4 HP:0004756 \| Ventricular tachycardia \| 4 HP:0002633 \| Vasculitis \| 3 HP:0001698 \| Pericardial effusions \| 3 HP:0004308 \| Ventricular arrhythmia \| 3 HP:0002383 \| Encephalitis \| 3 HP:0001298 \| Encephalopathy \| 3 HP:0001649 \| Tachycardia \| 3 HP:0002583 \| Colitis \| 3 HP:0003473 \| Fatigable weakness \| 3 HP:0001945 \| Fever \| 3 HP:0001645 \| Sudden cardiac death \| 3 HP:0100279 \| Ulcerative colitis \| 3 HP:0003201 \| Rhabdomyolysis \| 2 HP:0001880 \| Eosinophilia \| 2 HP:0100614 \| Muscle inflammation \| 2 HP:0001640 \| Increased heart size \| 2 HP:0002090 \| Pneumonia \| 2 HP:0002119 \| Ventricular dilatation \| 2 HP:0005162 \| Left ventricular impairment \| 2 HP:0001685 \| Myocardial fibrosis \| 2 HP:0100522 \| Thymoma \| 2 HP:0003072 \| Hypercalcemia \| 2 HP:0001733 \| Pancreatic inflammation \| 1 HP:0006690 \| Myocardial calcification \| 1 HP:0002099 \| Asthma \| 1 HP:0001653 \| Mitral valve insufficiency \| 1 HP:0200127 \| Atrial cardiomyopathy \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0001903 \| Anemia \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0001693 \| Cardiac shunt \| 1 HP:0011841 \| Ventricular flutter \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0100806 \| Sepsis \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0100584 \| Endocarditis \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0001629 \| Ventricular septal defects \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0001287 \| Meningitis \| 1 HP:0012722 \| Heart block \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0012089 \| Arteritis \| 1 HP:0005263 \| Gastritis \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001709 \| Complete heart block \| 1 HP:0001716 \| Wolff-Parkinson-White syndrome \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0002608 \| Celiac disease \| 1

Disease ID	725
Disease	myocarditis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:16) C0018801 \| heart failure \| 33 C0009450 \| infection \| 27 C0030193 \| pain \| 5 C0042769 \| virus infection \| 5 C0026691 \| kawasaki disease \| 5 C0018802 \| congestive heart failure \| 4 C0021079 \| immunosuppression \| 3 C0039231 \| tachycardia \| 3 C0021311 \| infections \| 3 C0085274 \| parvovirus b19 \| 2 C1959583 \| myocardial failure \| 2 C0040100 \| thymoma \| 2 C0151517 \| complete heart block \| 1 C0019158 \| hepatitis \| 1 C0018801 \| cardiac insufficiency \| 1 C0018802 \| congestive cardiac failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs3775291	23962581	7098	TLR3	umls:C0027059	BeFree	A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.	0.003181358	2013	TLR3	4	186082920	C	T,G
rs386586050	23962581	7098	TLR3	umls:C0027059	BeFree	A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.	0.003181358	2013	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:22)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0027059	acetylcysteine	D000111	616-91-1	myocarditis	MESH:D009205	therapeutic	9261645
C0027059	amitriptyline	D000639	50-48-6	myocarditis	MESH:D009205	marker/mechanism	12638679
C0027059	amphetamine	D000661	300-62-9	myocarditis	MESH:D009205	marker/mechanism	18791201
C0027059	ampicillin	D000667	69-53-4	myocarditis	MESH:D009205	marker/mechanism	7919560
C0027059	carbamazepine	D002220	298-46-4	myocarditis	MESH:D009205	marker/mechanism	20129423
C0027059	cephalexin	D002506	15686-71-2	myocarditis	MESH:D009205	marker/mechanism	17111287
C0027059	clozapine	D003024	5786-21-0	myocarditis	MESH:D009205	marker/mechanism	10584719
C0027059	cyclophosphamide	D003520	50-18-0	myocarditis	MESH:D009205	marker/mechanism	11041571
C0027059	dapsone	D003622	80-08-0	myocarditis	MESH:D009205	marker/mechanism	19583683
C0027059	fluorouracil	D005472	51-21-8	myocarditis	MESH:D009205	marker/mechanism	7954023
C0027059	haloperidol	D006220	52-86-8	myocarditis	MESH:D009205	marker/mechanism	17965989
C0027059	ifosfamide	D007069	3778-73-2	myocarditis	MESH:D009205	marker/mechanism	4833912
C0027059	imipramine	D007099	50-49-7	myocarditis	MESH:D009205	marker/mechanism	2760582
C0027059	lindane	D001556	58-89-9	myocarditis	MESH:D009205	marker/mechanism	1702244
C0027059	metoprolol	D008790	37350-58-6	myocarditis	MESH:D009205	marker/mechanism	17593350
C0027059	phenytoin	D010672	57-41-0	myocarditis	MESH:D009205	marker/mechanism	3421797
C0027059	propylthiouracil	D011441	51-52-5	myocarditis	MESH:D009205	marker/mechanism	9219172
C0027059	ticlopidine	D013988	55142-85-3	myocarditis	MESH:D009205	marker/mechanism	10533962
C0027059	tretinoin	D014212	302-79-4	myocarditis	MESH:D009205	marker/mechanism	15842672
C0027059	vitamin e	D014810	1406-18-4	myocarditis	MESH:D009205	marker/mechanism	1926593
C0027059	vitamin e	D014810	1406-18-4	myocarditis	MESH:D009205	therapeutic	12924018
C0027059	zidovudine	D015215	30516-87-1	myocarditis	MESH:D009205	marker/mechanism	1733387

FDA approved drug and dosage information(Total Drugs:6)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D009205	retrovir	zidovudine	100MG	CAPSULE;ORAL	Prescription	AB	Yes	Yes
MESH:D009205	retrovir	zidovudine	50MG/5ML	SYRUP;ORAL	Prescription	AA	Yes	Yes
MESH:D009205	retrovir	zidovudine	10MG/ML	INJECTABLE;INJECTION	Prescription	AP	Yes	Yes
MESH:D009205	retrovir	zidovudine	200MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D009205	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No
MESH:D009205	zidovudine	zidovudine	60MG	TABLET;ORAL	Discontinued	None	No	No

FDA labeling changes(Total Drugs:6)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D009205	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D009205	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D009205	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D009205	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D009205	09/19/2008	retrovir syrup, capsules and tablets	zidovudine	Used in combination with 18 other antiretroviral agents for the treatment of HIV-1 infection	Dosing and administration information provided to children 6 weeks to less than 18 years of age Macrocytosis was reported in the majority of pediatric patients receiving Retrovir 180 mg/m2 every 6 hours in open-label studies New dosing regimen	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'
MESH:D009205	6/11/2009	retrovir	zidovudine	Treatment of HIV-1 infection in combination with other antiretroviral agents	Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg	Labeling	-	P	-	-	GlaxoSmithKline	-	TRUE'