PedAM

Pediatric Disease Annotations & Medicines


	myeloid sarcoma

Disease ID	598
Disease	myeloid sarcoma
Definition	An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.
Synonym	[m]chloroma [m]granulocytic sarcoma [m]myeloid sarcoma cancer, green chloroleukemia chloroma chloroma (disorder) chloromas chloromyeloma chlorosarcoma extramedullary myeloid cell tumor extramedullary myeloid tumor granulocytic sarcoma granulocytic sarcoma (disorder) granulocytic sarcomas myeloid cell tumor, extramedullary myeloid sarcoma nos myeloid sarcoma nos (disorder) myeloid sarcoma, disease myeloid sarcoma, disease (disorder) myeloid sarcoma, morphology myeloid sarcoma, morphology (morphologic abnormality) myeloid sarcomas myelosarcoma sarcoma granulocytic sarcoma, granulocytic sarcoma, granulocytic, malignant sarcoma, myeloid sarcoma, myeloid [disease/finding] sarcoma, myeloid, malignant sarcomas, granulocytic sarcomas, myeloid
Orphanet	ORPHANET:86850
DOID	DOID:8683
UMLS	C0152276
MeSH	D023981
SNOMED-CT	SNOMEDCT_US_2016_09_01:188737002;SNOMEDCT_US_2016_09_01:94719007;SNOMEDCT_US_2016_09_01:188738007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:20) C0023467 \| acute myeloid leukemia \| 9 C0023470 \| myeloid leukemia \| 7 C0023418 \| leukemia \| 7 C0023487 \| acute promyelocytic leukemia \| 2 C0023470 \| myelocytic leukemia \| 2 C0008625 \| chromosomal abnormality \| 2 C0026986 \| myelodysplastic syndrome \| 2 C0023487 \| promyelocytic leukemia \| 2 C0700251 \| brachial plexopathy \| 1 C0023470 \| myelogenous leukemia \| 1 C0080032 \| malignant pleural effusion \| 1 C0836924 \| thrombocythemia \| 1 C1261473 \| sarcomas \| 1 C0023473 \| chronic myelogenous leukemia \| 1 C0027022 \| myeloproliferative neoplasms \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0023467 \| acute myeloblastic leukemia \| 1 C0040028 \| essential thrombocythemia \| 1 C0021843 \| intestinal obstruction \| 1 C1335437 \| plexopathy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:80) 973 \| CD79A \| DISEASES 4353 \| MPO \| DISEASES 2703 \| GJA8 \| DISEASES 2322 \| FLT3 \| DISEASES 3223 \| HOXC6 \| DISEASES 968 \| CD68 \| DISEASES 7837 \| PXDN \| DISEASES 5914 \| RARA \| DISEASES 10752 \| CHL1 \| DISEASES 5156 \| PDGFRA \| DISEASES 9883 \| POM121 \| DISEASES 10113 \| PREB \| DISEASES 4069 \| LYZ \| DISEASES 4001 \| LMNB1 \| DISEASES 5687 \| PSMA6 \| DISEASES 3690 \| ITGB3 \| DISEASES 945 \| CD33 \| DISEASES 8178 \| ELL \| DISEASES 9410 \| SNRNP40 \| DISEASES 943 \| TNFRSF8 \| DISEASES 2208 \| FCER2 \| DISEASES 64374 \| SIL1 \| DISEASES 150094 \| SIK1 \| DISEASES 7345 \| UCHL1 \| DISEASES 3815 \| KIT \| DISEASES 3678 \| ITGA5 \| DISEASES 4869 \| NPM1 \| DISEASES 290 \| ANPEP \| DISEASES 861 \| RUNX1 \| DISEASES 3221 \| HOXC4 \| DISEASES 8028 \| MLLT10 \| DISEASES 794 \| CALB2 \| DISEASES 3222 \| HOXC5 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 924 \| CD7 \| DISEASES 4684 \| NCAM1 \| DISEASES 3563 \| IL3RA \| DISEASES 2811 \| GP1BA \| DISEASES 7490 \| WT1 \| DISEASES 284361 \| EMC10 \| DISEASES 81608 \| FIP1L1 \| DISEASES 23583 \| SMUG1 \| DISEASES 921 \| CD5 \| DISEASES 9218 \| VAPA \| DISEASES 3767 \| KCNJ11 \| DISEASES 3683 \| ITGAL \| DISEASES 5079 \| PAX5 \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 6693 \| SPN \| DISEASES 170482 \| CLEC4C \| DISEASES 4311 \| MME \| DISEASES 2993 \| GYPA \| DISEASES 5788 \| PTPRC \| DISEASES 962 \| CD48 \| DISEASES 6280 \| S100A9 \| DISEASES 2209 \| FCGR1A \| DISEASES 914 \| CD2 \| DISEASES 5236 \| PGM1 \| DISEASES 1791 \| DNTT \| DISEASES 25 \| ABL1 \| DISEASES 11040 \| PIM2 \| DISEASES 8418 \| CMAHP \| DISEASES 5420 \| PODXL \| DISEASES 6239 \| RREB1 \| DISEASES 54790 \| TET2 \| DISEASES 4300 \| MLLT3 \| DISEASES 4267 \| CD99 \| DISEASES 3717 \| JAK2 \| DISEASES 7750 \| ZMYM2 \| DISEASES 238 \| ALK \| DISEASES 3239 \| HOXD13 \| DISEASES 8301 \| PICALM \| DISEASES 55193 \| PBRM1 \| DISEASES 27040 \| LAT \| DISEASES 4629 \| MYH11 \| DISEASES 862 \| RUNX1T1 \| DISEASES 196527 \| ANO6 \| DISEASES 930 \| CD19 \| DISEASES
Locus	(Waiting for update.)

Disease ID	598
Disease	myeloid sarcoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0004808 \| Acute myelogenous leukemia \| 10 HP:0001909 \| Leukemia \| 7 HP:0012324 \| Myeloid leukemia \| 7 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0004836 \| Acute promyelocytic leukemia \| 2 HP:0005214 \| Bowel obstruction \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0011880 \| Acute disseminated intravascular coagulation \| 1 HP:0005506 \| Chronic myeloid leukemia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1

Disease ID	598
Disease	myeloid sarcoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:2) C0700594 \| radiculopathy C0221383 \| phlegmonous gastritis
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs386626619	22041374	3717	JAK2	umls:C0152276	BeFree	This report describes the first case of myeloid sarcoma with JAK2 V617F mutation and implication of its progression to AML.	0.000542884	2011	NA	NA	NA	NA	NA
rs386626619	24118374	3717	JAK2	umls:C0152276	BeFree	In addition, homozygous JAK2 V617F mutation was detected from the myeloid sarcoma specimen.	0.000542884	2013	NA	NA	NA	NA	NA
rs77375493	24118374	3717	JAK2	umls:C0152276	BeFree	In addition, homozygous JAK2 V617F mutation was detected from the myeloid sarcoma specimen.	0.000542884	2013	JAK2;INSL6	9	5073770	G	A,T
rs77375493	22041374	3717	JAK2	umls:C0152276	BeFree	This report describes the first case of myeloid sarcoma with JAK2 V617F mutation and implication of its progression to AML.	0.000542884	2011	JAK2;INSL6	9	5073770	G	A,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0152276	melphalan	D008558	148-82-3	sarcoma, myeloid	MESH:D023981	marker/mechanism	11099330

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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