PedAM

Pediatric Disease Annotations & Medicines


	mycosis fungoides

Disease ID	93
Disease	mycosis fungoides
Definition	A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
Synonym	[m]mycosis fungoides [m]mycosis fungoides (disorder) [m]mycosis fungoides nos [m]mycosis fungoides nos (morphologic abnormality) ctcl/ mycosis fungoides cutaneous t-cell lymphoma/mycosis fungoides granuloma, fungoides mf - mycosis fungoides mycosis fungoides (clinical) mycosis fungoides (disorder) mycosis fungoides (morphologic abnormality) mycosis fungoides [disease/finding] mycosis fungoides lymphoma mycosis fungoides nos mycosis fungoides nos (disorder) mycosis fungoides of unspecified site mycosis fungoides of unspecified site (disorder)
OMIM	OMIM:254400
DOID	DOID:8691
UMLS	C0026948
MeSH	D009182
SNOMED-CT	SNOMEDCT_US_2016_09_01:118618005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:42) C0002173 \| follicular mucinosis \| 5 C0024299 \| lymphoma \| 4 C0162855 \| mucinosis \| 4 C1276146 \| cutaneous lymphoma \| 2 C0002726 \| amyloidosis \| 2 C0206180 \| anaplastic large-cell lymphoma \| 1 C0037274 \| dermatosis \| 1 C0024299 \| lymphomas \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0017661 \| iga nephropathy \| 1 C0037998 \| splenic infarction \| 1 C0002170 \| alopecia \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0042373 \| vascular disease \| 1 C0000889 \| acanthosis nigricans \| 1 C0409974 \| lupus erythematosus \| 1 C0334254 \| lymphoepithelioma \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0030805 \| bullous pemphigoid \| 1 C0033860 \| psoriasis \| 1 C0520679 \| obstructive sleep apnea \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0268397 \| cutaneous amyloidosis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0016436 \| folliculitis \| 1 C0039590 \| testicular cancer \| 1 C1332362 \| b-cell neoplasm \| 1 C0023448 \| lymphocytic leukaemia \| 1 C0020437 \| hypercalcemia \| 1 C0011603 \| dermatitis \| 1 C0036920 \| sezary syndrome \| 1 C1302772 \| primary cutaneous lymphoma \| 1 C0023434 \| chronic lymphocytic leukaemia \| 1 C0007222 \| cardiovascular disease \| 1 C0079773 \| cutaneous t-cell lymphoma \| 1 C0019829 \| hodgkin lymphoma \| 1 C0037315 \| sleep apnea \| 1 C0022658 \| nephropathy \| 1 C0023348 \| lepromatous leprosy \| 1 C0152965 \| staphylococcal sepsis \| 1 C0042109 \| urticarial \| 1 C0021843 \| bowel obstruction \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) TNFRSF1B \| 7133 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:206) 6362 \| CCL18 \| DISEASES 10344 \| CCL26 \| DISEASES 933 \| CD22 \| DISEASES 3385 \| ICAM3 \| DISEASES 9319 \| TRIP13 \| DISEASES 30009 \| TBX21 \| DISEASES 3002 \| GZMB \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 973 \| CD79A \| DISEASES 4818 \| NKG7 \| DISEASES 3558 \| IL2 \| DISEASES 55801 \| IL26 \| DISEASES 3458 \| IFNG \| DISEASES 4172 \| MCM3 \| DISEASES 4188 \| MDFI \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 604 \| BCL6 \| DISEASES 5948 \| RBP2 \| DISEASES 11126 \| CD160 \| DISEASES 6402 \| SELL \| DISEASES 3070 \| HELLS \| DISEASES 4360 \| MRC1 \| DISEASES 79441 \| HAUS3 \| DISEASES 5335 \| PLCG1 \| DISEASES 10893 \| MMP24 \| DISEASES 1236 \| CCR7 \| DISEASES 10875 \| FGL2 \| DISEASES 968 \| CD68 \| DISEASES 1036 \| CDO1 \| DISEASES 79977 \| GRHL2 \| DISEASES 83483 \| PLVAP \| DISEASES 3727 \| JUND \| DISEASES 10752 \| CHL1 \| DISEASES 29969 \| MDFIC \| DISEASES 4836 \| NMT1 \| DISEASES 6366 \| CCL21 \| DISEASES 10850 \| CCL27 \| DISEASES 9099 \| USP2 \| DISEASES 10113 \| PREB \| DISEASES 5862 \| RAB2A \| DISEASES 5264 \| PHYH \| DISEASES 3682 \| ITGAE \| DISEASES 3574 \| IL7 \| DISEASES 10578 \| GNLY \| DISEASES 943 \| TNFRSF8 \| DISEASES 867 \| CBL \| DISEASES 10382 \| TUBB4A \| DISEASES 6774 \| STAT3 \| DISEASES 3383 \| ICAM1 \| DISEASES 27074 \| LAMP3 \| DISEASES 7112 \| TMPO \| DISEASES 54509 \| RHOF \| DISEASES 7157 \| TP53 \| DISEASES 1939 \| EIF2D \| DISEASES 2052 \| EPHX1 \| DISEASES 9180 \| OSMR \| DISEASES 3001 \| GZMA \| DISEASES 1030 \| CDKN2B \| DISEASES 3439 \| IFNA1 \| DISEASES 7424 \| VEGFC \| DISEASES 4154 \| MBNL1 \| DISEASES 3672 \| ITGA1 \| DISEASES 925 \| CD8A \| DISEASES 7070 \| THY1 \| DISEASES 7345 \| UCHL1 \| DISEASES 7508 \| XPC \| DISEASES 9337 \| CNOT8 \| DISEASES 10563 \| CXCL13 \| DISEASES 9372 \| ZFYVE9 \| DISEASES 9437 \| NCR1 \| DISEASES 1234 \| CCR5 \| DISEASES 6777 \| STAT5B \| DISEASES 10630 \| PDPN \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 3577 \| CXCR1 \| DISEASES 3600 \| IL15 \| DISEASES 9265 \| CYTH3 \| DISEASES 10922 \| FASTK \| DISEASES 10206 \| TRIM13 \| DISEASES 94235 \| GNG8 \| DISEASES 353514 \| LILRA5 \| DISEASES 3603 \| IL16 \| DISEASES 3689 \| ITGB2 \| DISEASES 3688 \| ITGB1 \| DISEASES 121355 \| GTSF1 \| DISEASES 171558 \| PTCRA \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 6373 \| CXCL11 \| DISEASES 27087 \| B3GAT1 \| DISEASES 8763 \| CD164 \| DISEASES 947 \| CD34 \| DISEASES 924 \| CD7 \| DISEASES 666 \| BOK \| DISEASES 1191 \| CLU \| DISEASES 6047 \| RNF4 \| DISEASES 30835 \| CD209 \| DISEASES 6773 \| STAT2 \| DISEASES 57381 \| RHOJ \| DISEASES 4684 \| NCAM1 \| DISEASES 29851 \| ICOS \| DISEASES 10938 \| EHD1 \| DISEASES 9235 \| IL32 \| DISEASES 3812 \| KIR3DL2 \| DISEASES 64332 \| NFKBIZ \| DISEASES 1237 \| CCR8 \| DISEASES 6401 \| SELE \| DISEASES 3838 \| KPNA2 \| DISEASES 5133 \| PDCD1 \| DISEASES 9094 \| UNC119 \| DISEASES 112744 \| IL17F \| DISEASES 8631 \| SKAP1 \| DISEASES 23583 \| SMUG1 \| DISEASES 7060 \| THBS4 \| DISEASES 6776 \| STAT5A \| DISEASES 54345 \| SOX18 \| DISEASES 921 \| CD5 \| DISEASES 56940 \| DUSP22 \| DISEASES 80705 \| TSGA10 \| DISEASES 355 \| FAS \| DISEASES 5358 \| PLS3 \| DISEASES 140885 \| SIRPA \| DISEASES 3683 \| ITGAL \| DISEASES 64919 \| BCL11B \| DISEASES 5079 \| PAX5 \| DISEASES 26052 \| DNM3 \| DISEASES 6775 \| STAT4 \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 7037 \| TFRC \| DISEASES 6693 \| SPN \| DISEASES 170482 \| CLEC4C \| DISEASES 4311 \| MME \| DISEASES 1803 \| DPP4 \| DISEASES 9760 \| TOX \| DISEASES 4283 \| CXCL9 \| DISEASES 80342 \| TRAF3IP3 \| DISEASES 1380 \| CR2 \| DISEASES 5788 \| PTPRC \| DISEASES 51696 \| HECA \| DISEASES 2214 \| FCGR3A \| DISEASES 51744 \| CD244 \| DISEASES 115352 \| FCRL3 \| DISEASES 6278 \| S100A7 \| DISEASES 6280 \| S100A9 \| DISEASES 4942 \| OAT \| DISEASES 5406 \| PNLIP \| DISEASES 914 \| CD2 \| DISEASES 6847 \| SYCP1 \| DISEASES 959 \| CD40LG \| DISEASES 1791 \| DNTT \| DISEASES 51213 \| LUZP4 \| DISEASES 2833 \| CXCR3 \| DISEASES 3561 \| IL2RG \| DISEASES 1043 \| CD52 \| DISEASES 6257 \| RXRB \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 548313 \| SSX4B \| DISEASES 6759 \| SSX4 \| DISEASES 386653 \| IL31 \| DISEASES 4609 \| MYC \| DISEASES 10497 \| UNC13B \| DISEASES 7293 \| TNFRSF4 \| DISEASES 2625 \| GATA3 \| DISEASES 3559 \| IL2RA \| DISEASES 4507 \| MTAP \| DISEASES 3440 \| IFNA2 \| DISEASES 3662 \| IRF4 \| DISEASES 51378 \| ANGPT4 \| DISEASES 6624 \| FSCN1 \| DISEASES 238 \| ALK \| DISEASES 3811 \| KIR3DL1 \| DISEASES 9349 \| RPL23 \| DISEASES 56666 \| PANX2 \| DISEASES 3676 \| ITGA4 \| DISEASES 7110 \| TMF1 \| DISEASES 50489 \| CD207 \| DISEASES 3718 \| JAK3 \| DISEASES 1029 \| CDKN2A \| DISEASES 147920 \| IGFL2 \| DISEASES 7124 \| TNF \| DISEASES 6304 \| SATB1 \| DISEASES 7072 \| TIA1 \| DISEASES 54900 \| LAX1 \| DISEASES 3586 \| IL10 \| DISEASES 338376 \| IFNE \| DISEASES 5793 \| PTPRG \| DISEASES 30816 \| ERVW-1 \| DISEASES 2533 \| FYB \| DISEASES 930 \| CD19 \| DISEASES 387357 \| THEMIS \| DISEASES 488 \| ATP2A2 \| DISEASES 7694 \| ZNF135 \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 605 \| BCL7A \| DISEASES 89795 \| NAV3 \| DISEASES 567 \| B2M \| DISEASES 85316 \| BAGE5 \| DISEASES 100302740 \| FAS-AS1 \| DISEASES 407975 \| MIR17HG \| DISEASES 26801 \| SNORD48 \| DISEASES
Locus	(Waiting for update.)

Disease ID	93
Disease	mycosis fungoides
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:7) HP:0002665 \| Lymphoma HP:0008069 \| Neoplasm of the skin HP:0000964 \| Eczema HP:0000989 \| pruritis HP:0200035 \| Skin plaque HP:0010783 \| Erythema HP:0002716 \| Lymph node hyperplasia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:25) HP:0002665 \| Lymphoma \| 4 HP:0012190 \| T cell lymphoma \| 3 HP:0001596 \| Hair loss \| 2 HP:0011034 \| Amyloid disease \| 2 HP:0002664 \| Neoplasia \| 2 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0010783 \| Erythema \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0012192 \| Cutaneous T-cell lymphoma \| 1 HP:0012193 \| Anaplastic large-cell lymphoma \| 1 HP:0000956 \| Keratosis nigricans \| 1 HP:0003765 \| Psoriasis \| 1 HP:0002835 \| Aspiration \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0000112 \| Nephropathy \| 1 HP:0012309 \| Cutaneous amyloidosis \| 1 HP:0030731 \| Carcinoma \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0000966 \| Decreased sweating \| 1 HP:0003072 \| Hypercalcemia \| 1

Disease ID	93
Disease	mycosis fungoides
Manually Symptom	UMLS \| Name(Total Manually Symptoms:77) C2717981 \| poromas C2697310 \| sarcoidosis C2240374 \| eosinophilia C2116082 \| thyroid nodule C1963254 \| tumor lysis syndrome C1963139 \| hypopigmentation C1565489 \| renal insufficiency C1373218 \| immunosuppression C1368404 \| hypopharyngeal carcinoma C1367970 \| pagetoid reticulosis C1336753 \| lymphoma of the thyroid gland C1333177 \| lymphoproliferative disorder of the skin C1000483 \| anemia C0936250 \| eczema herpeticum C0920350 \| hashimoto thyroiditis C0870082 \| hyperkeratosis C0748159 \| pulmonary involvement C0545080 \| composite lymphoma C0497156 \| lymphadenopathy C0475858 \| generalized pruritus C0442874 \| neuropathy C0403766 \| phimosis C0272398 \| dermatopathic lymphadenopathy C0271683 \| motor polyneuropathy C0268749 \| immunotactoid glomerulopathy C0268397 \| cutaneous amyloidosis C0263396 \| pigmented purpuric eruption C0238790 \| bone destruction C0238419 \| fournier's gangrene C0235896 \| lung infiltration C0221348 \| yellow nail syndrome C0221207 \| cold urticaria C0206744 \| idiopathic cd4+ t lymphocytopenia C0206182 \| lymphomatoid papulosis C0162855 \| mucinosis C0155365 \| disorder of vitreous C0150988 \| sclerodactyly C0085636 \| light sensitivity C0079772 \| t-cell lymphomas C0051981 \| leprosy C0043325 \| xanthomatosis C0042338 \| herpes zoster C0037926 \| spinal cord compression C0037299 \| skin ulcers C0037285 \| skin manifestation C0037284 \| skin lesions C0031117 \| peripheral neuropathy C0029166 \| oral manifestations C0027697 \| nephritis C0025202 \| malignant melanoma C0024958 \| maxillary sinus tumor C0024299 \| lymphomas C0024299 \| lymphoma C0022660 \| acute renal failure C0022603 \| seborrheic keratosis C0022568 \| keratitis C0022504 \| kaposi's varicelliform eruption C0022354 \| obstructive jaundice C0021843 \| intestinal obstruction C0021051 \| immunologic deficiency syndromes C0020598 \| hypocalcemia C0020097 \| htlv-i infection C0020097 \| htlv-i C0019829 \| hodgkin's lymphoma C0019829 \| hodgkin's disease C0019829 \| hodgkin lymphoma C0019372 \| herpes infection C0010043 \| ulcerative keratitis C0008489 \| chorea C0007137 \| squamous cell carcinomas C0007117 \| basal cell carcinomas C0003864 \| arthritis C0002880 \| autoimmune hemolytic anemia C0002514 \| hyperaminoaciduria C0002173 \| follicular mucinosis C0002173 \| alopecia mucinosa C0000889 \| acanthosis nigricans
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:12) C0002173 \| follicular mucinosis \| 5 C0162855 \| mucinosis \| 4 C0024299 \| lymphoma \| 4 C0206182 \| lymphomatoid papulosis \| 2 C0014457 \| eosinophilia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0037284 \| skin lesions \| 1 C0024299 \| lymphomas \| 1 C1367970 \| pagetoid reticulosis \| 1 C1333177 \| lymphoproliferative disorder of the skin \| 1 C0000889 \| acanthosis nigricans \| 1 C0268397 \| cutaneous amyloidosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042522	17107393	7157	TP53	umls:C0026948	BeFree	Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides.	0.001900093	2006	TP53	17	7676154	G	T,C
rs112445441	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	KRAS	12	25245347	C	A,G,T
rs11540654	17107393	7157	TP53	umls:C0026948	BeFree	Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides.	0.001900093	2006	TP53	17	7676040	C	T,G,A
rs121434596	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	NRAS	1	114716123	C	T,G,A
rs121913238	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	KRAS	12	25227343	G	T,C
rs121913254	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	NRAS	1	114713909	G	T,C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001890	Autoimmune hemolytic anemia	MP:0001577	anemia;HP:0012189	Hodgkin lymphoma

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002716	Lymphadenopathy	MP:0002420	abnormal adaptive immunity;HP:0001890	Autoimmune hemolytic anemia

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0026948	arsenic trioxide	C006632	1327-53-3	mycosis fungoides	MESH:D009182	therapeutic	18349030
C0026948	carmustine	D002330	154-93-8	mycosis fungoides	MESH:D009182	therapeutic	16631939
C0026948	methoxsalen	D008730	298-81-7	mycosis fungoides	MESH:D009182	therapeutic	16259964
C0026948	vincristine	D014750	-	mycosis fungoides	MESH:D009182	therapeutic	1850399

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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