PedAM

Pediatric Disease Annotations & Medicines


	multidrug-resistant tuberculosis

Disease ID	1829
Disease	multidrug-resistant tuberculosis
Definition	Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Synonym	mdr tuberculosis mdr-tb multi drug resistant tuberculosis multi-drug resistant tuberculosis multidrug resistant tuberculosis multidrug resistant tuberculosis (disorder) multidrug-resistant tb tuberculosis, mdr tuberculosis, multi drug resistant tuberculosis, multi-drug resistant tuberculosis, multidrug resistant tuberculosis, multidrug-resistant tuberculosis, multidrug-resistant [disease/finding]
DOID	DOID:401
UMLS	C0206526
MeSH	D018088
SNOMED-CT	SNOMEDCT_US_2016_09_01:423092005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:7) C0041296 \| tuberculosis \| 5 C0041327 \| pulmonary tuberculosis \| 1 C0024117 \| chronic obstructive pulmonary disease \| 1 C0600260 \| obstructive pulmonary disease \| 1 C0024115 \| pulmonary disease \| 1 C0020676 \| hypothyroidism \| 1 C0002726 \| amyloidosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:112) 158 \| ADSL \| DISEASES 1591 \| CYP24A1 \| DISEASES 6346 \| CCL1 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 6206 \| RPS12 \| DISEASES 6908 \| TBP \| DISEASES 6556 \| SLC11A1 \| DISEASES 847 \| CAT \| DISEASES 10804 \| GJB6 \| DISEASES 5552 \| SRGN \| DISEASES 3623 \| INHA \| DISEASES 7355 \| SLC35A2 \| DISEASES 7263 \| TST \| DISEASES 6299 \| SALL1 \| DISEASES 967 \| CD63 \| DISEASES 83888 \| FGFBP2 \| DISEASES 9360 \| PPIG \| DISEASES 5037 \| PEBP1 \| DISEASES 8099 \| CDK2AP1 \| DISEASES 10858 \| CYP46A1 \| DISEASES 6521 \| SLC4A1 \| DISEASES 25939 \| SAMHD1 \| DISEASES 8647 \| ABCB11 \| DISEASES 10578 \| GNLY \| DISEASES 80725 \| SRCIN1 \| DISEASES 25824 \| PRDX5 \| DISEASES 5244 \| ABCB4 \| DISEASES 10769 \| PLK2 \| DISEASES 391059 \| FRRS1 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 10085 \| EDIL3 \| DISEASES 1437 \| CSF2 \| DISEASES 1548 \| CYP2A6 \| DISEASES 143501 \| C11orf40 \| DISEASES 29 \| ABR \| DISEASES 375611 \| SLC26A5 \| DISEASES 3575 \| IL7R \| DISEASES 10102 \| TSFM \| DISEASES 163 \| AP2B1 \| DISEASES 30835 \| CD209 \| DISEASES 5551 \| PRF1 \| DISEASES 53347 \| UBASH3A \| DISEASES 8685 \| MARCO \| DISEASES 9322 \| TRIP10 \| DISEASES 10938 \| EHD1 \| DISEASES 2274 \| FHL2 \| DISEASES 4843 \| NOS2 \| DISEASES 5454 \| POU3F2 \| DISEASES 25834 \| MGAT4C \| DISEASES 9939 \| RBM8A \| DISEASES 340075 \| ARSI \| DISEASES 1908 \| EDN3 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3329 \| HSPD1 \| DISEASES 2804 \| GOLGB1 \| DISEASES 3921 \| RPSA \| DISEASES 26503 \| SLC17A5 \| DISEASES 91137 \| SLC25A46 \| DISEASES 51155 \| HN1 \| DISEASES 9600 \| PITPNM1 \| DISEASES 6775 \| STAT4 \| DISEASES 9464 \| HAND2 \| DISEASES 6772 \| STAT1 \| DISEASES 4519 \| MT-CYB \| DISEASES 4537 \| MT-ND3 \| DISEASES 2987 \| GUK1 \| DISEASES 6580 \| SLC22A1 \| DISEASES 1660 \| DHX9 \| DISEASES 26002 \| MOXD1 \| DISEASES 3645 \| INSRR \| DISEASES 103 \| ADAR \| DISEASES 7062 \| TCHH \| DISEASES 9124 \| PDLIM1 \| DISEASES 1558 \| CYP2C8 \| DISEASES 1557 \| CYP2C19 \| DISEASES 958 \| CD40 \| DISEASES 80712 \| ESX1 \| DISEASES 129685 \| TAF8 \| DISEASES 27286 \| SRPX2 \| DISEASES 5292 \| PIM1 \| DISEASES 4153 \| MBL2 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 23254 \| KAZN \| DISEASES 50943 \| FOXP3 \| DISEASES 3107 \| HLA-C \| DISEASES 160897 \| GPR180 \| DISEASES 387755 \| INSC \| DISEASES 79625 \| NDNF \| DISEASES 2762 \| GMDS \| DISEASES 56341 \| PRMT8 \| DISEASES 6710 \| SPTB \| DISEASES 114609 \| TIRAP \| DISEASES 29994 \| BAZ2B \| DISEASES 10379 \| IRF9 \| DISEASES 6335 \| SCN9A \| DISEASES 23759 \| PPIL2 \| DISEASES 7124 \| TNF \| DISEASES 862 \| RUNX1T1 \| DISEASES 2900 \| GRIK4 \| DISEASES 4152 \| MBD1 \| DISEASES 408 \| ARRB1 \| DISEASES 3586 \| IL10 \| DISEASES 5158 \| PDE6B \| DISEASES 23022 \| PALLD \| DISEASES 5027 \| P2RX7 \| DISEASES 8725 \| URI1 \| DISEASES 4549 \| MT-RNR1 \| DISEASES 23642 \| SNHG1 \| DISEASES 6082 \| SNORD20 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1829
Disease	multidrug-resistant tuberculosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:4) HP:0002721 \| Immunodeficiency \| 3 HP:0000821 \| Underactive thyroid \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0006510 \| Chronic obstructive pulmonary disease \| 1

Disease ID	1829
Disease	multidrug-resistant tuberculosis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0206526	aminosalicylic acid	D010131	65-49-6	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	18283911
C0206526	capreomycin	D002207	11003-38-6	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	15006956
C0206526	cycloserine	D003523	68-41-7	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	15182146
C0206526	entacapone	C071192	116314-67-1	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	19578428
C0206526	ethambutol	D004977	74-55-5	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	1096388
C0206526	ethionamide	D005000	536-33-4	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	18283911
C0206526	ofloxacin	D015242	82419-36-1	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	16178466
C0206526	pyrazinamide	D011718	98-96-4	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	18283911
C0206526	rifampin	D012293	13292-46-1	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	1096388
C0206526	tolcapone	C066340	134308-13-7	tuberculosis, multidrug-resistant	MESH:D018088	therapeutic	19578428

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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