PedAM

Pediatric Disease Annotations & Medicines


	motion sickness

Disease ID	488
Disease	motion sickness
Definition	Disorder caused by motion, as sea sickness, train sickness, car sickness, air sickness, or SPACE MOTION SICKNESS. It may include nausea, vomiting and dizziness.
Synonym	motion sickness (disorder) motion sickness (finding) motion sickness [disease/finding] motion sickness nos motion sickness nos (disorder) motion sickness nos (finding) motion sickness, nos riders' vertigo sickness, motion travel sickness travel sickness (disorder) travel sickness, unspecified travel sickness, unspecified (disorder) travel sickness, unspecified (finding)
OMIM	OMIM:158280
DOID	DOID:2951
UMLS	C0026603
MeSH	D009041
SNOMED-CT	SNOMEDCT_US_2016_09_01:37031009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:10) C0149931 \| migraine \| 6 C0028754 \| obesity \| 5 C0021831 \| intestinal disease \| 1 C0037274 \| skin disease \| 1 C0020538 \| hypertension \| 1 C0003615 \| appendicitis \| 1 C0017178 \| gastrointestinal disease \| 1 C0008311 \| cholangitis \| 1 C0011847 \| diabetes \| 1 C0003467 \| anxiety \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:17) CELF2 \| 10659 \| GWASCAT MAP2K5 \| 5607 \| GWASCAT NLGN1 \| 22871 \| GWASCAT AUTS2 \| 26053 \| GWASCAT LINC00924 \| 145820 \| GWASCAT PRDM16 \| 63976 \| GWASCAT LRP1B \| 53353 \| GWASCAT HOXB3 \| 3213 \| GWASCAT POU6F2 \| 11281 \| GWASCAT LINC01243 \| 101929620 \| GWASCAT LINC01241 \| 101929582 \| GWASCAT GPD2 \| 2820 \| GWASCAT HOXD3 \| 3232 \| GWASCAT SDK1 \| 221935 \| GWASCAT ST18 \| 9705 \| GWASCAT CPNE4 \| 131034 \| GWASCAT PDZRN4 \| 29951 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 150 \| ADRA2A \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:97) 84908 \| FAM136A \| DISEASES 4320 \| MMP11 \| DISEASES 1690 \| COCH \| DISEASES 55916 \| NXT2 \| DISEASES 1577 \| CYP3A5 \| DISEASES 5539 \| PPY \| DISEASES 4848 \| CNOT2 \| DISEASES 56269 \| IRGC \| DISEASES 3232 \| HOXD3 \| DISEASES 10053 \| AP1M2 \| DISEASES 9360 \| PPIG \| DISEASES 9132 \| KCNQ4 \| DISEASES 8540 \| AGPS \| DISEASES 5443 \| POMC \| DISEASES 11343 \| MGLL \| DISEASES 6895 \| TARBP2 \| DISEASES 60314 \| C12orf10 \| DISEASES 5972 \| REN \| DISEASES 3358 \| HTR2C \| DISEASES 90525 \| SHF \| DISEASES 1173 \| AP2M1 \| DISEASES 4041 \| LRP5 \| DISEASES 152185 \| SPICE1 \| DISEASES 84315 \| MON1A \| DISEASES 364 \| AQP7 \| DISEASES 5617 \| PRL \| DISEASES 6869 \| TACR1 \| DISEASES 2353 \| FOS \| DISEASES 3213 \| HOXB3 \| DISEASES 1657 \| DMXL1 \| DISEASES 171389 \| NLRP6 \| DISEASES 358 \| AQP1 \| DISEASES 3352 \| HTR1D \| DISEASES 3350 \| HTR1A \| DISEASES 57217 \| TTC7A \| DISEASES 64388 \| GREM2 \| DISEASES 363 \| AQP6 \| DISEASES 10938 \| EHD1 \| DISEASES 6863 \| TAC1 \| DISEASES 10194 \| TSHZ1 \| DISEASES 51341 \| ZBTB7A \| DISEASES 131149 \| OTOL1 \| DISEASES 2520 \| GAST \| DISEASES 5797 \| PTPRM \| DISEASES 25987 \| TSKU \| DISEASES 9939 \| RBM8A \| DISEASES 51738 \| GHRL \| DISEASES 327657 \| SERPINA9 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3363 \| HTR7 \| DISEASES 2261 \| FGFR3 \| DISEASES 222236 \| NAPEPLD \| DISEASES 6609 \| SMPD1 \| DISEASES 9588 \| PRDX6 \| DISEASES 9536 \| PTGES \| DISEASES 1811 \| SLC26A3 \| DISEASES 2879 \| GPX4 \| DISEASES 3792 \| KEL \| DISEASES 3359 \| HTR3A \| DISEASES 3360 \| HTR4 \| DISEASES 1118 \| CHIT1 \| DISEASES 7432 \| VIP \| DISEASES 1268 \| CNR1 \| DISEASES 4803 \| NGF \| DISEASES 1137 \| CHRNA4 \| DISEASES 26036 \| ZNF451 \| DISEASES 26027 \| ACOT11 \| DISEASES 6406 \| SEMG1 \| DISEASES 9968 \| MED12 \| DISEASES 1269 \| CNR2 \| DISEASES 2159 \| F10 \| DISEASES 79180 \| EFHD2 \| DISEASES 127262 \| TPRG1L \| DISEASES 3980 \| LIG3 \| DISEASES 551 \| AVP \| DISEASES 5618 \| PRLR \| DISEASES 3786 \| KCNQ3 \| DISEASES 2524 \| FUT2 \| DISEASES 6046 \| BRD2 \| DISEASES 2132 \| EXT2 \| DISEASES 3269 \| HRH1 \| DISEASES 63915 \| BLOC1S5 \| DISEASES 1837 \| DTNA \| DISEASES 643418 \| LIPN \| DISEASES 7514 \| XPO1 \| DISEASES 1385 \| CREB1 \| DISEASES 4295 \| MLN \| DISEASES 4988 \| OPRM1 \| DISEASES 6464 \| SHC1 \| DISEASES 64084 \| CLSTN2 \| DISEASES 4152 \| MBD1 \| DISEASES 627 \| BDNF \| DISEASES 246744 \| STH \| DISEASES 5125 \| PCSK5 \| DISEASES 8972 \| MGAM \| DISEASES 5726 \| TAS2R38 \| DISEASES 101 \| ADAM8 \| DISEASES
Locus	(Waiting for update.)

Disease ID	488
Disease	motion sickness
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0000707 \| Neurological abnormality
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0002018 \| Nausea \| 10 HP:0002013 \| Emesis \| 10 HP:0002076 \| Migraine headaches \| 6 HP:0001513 \| Obesity \| 5 HP:0002017 \| Nausea and vomiting \| 4 HP:0100785 \| Insomnia \| 1 HP:0030151 \| Cholangitis \| 1 HP:0001751 \| Vestibular dysfunction \| 1 HP:0000822 \| Hypertension \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0001824 \| Weight loss \| 1 HP:0000739 \| Anxiety \| 1 HP:0002172 \| Postural instability \| 1

Disease ID	488
Disease	motion sickness
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0027497 \| nausea \| 10 C0042963 \| vomiting \| 9 C0231218 \| malaise \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:19)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10752212	25628336	10659	CELF2	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	NA	10	10875158	G	A
rs10970305	25628336	101929620	LINC01243	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	LINC01243	9	31372585	A	C
rs11713169	25628336	22871	NLGN1	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	NLGN1	3	173666799	A	C
rs17515225	25628336	53353	LRP1B	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	LRP1B	2	140788186	T	C
rs1782032	25628336	101929582	LINC01241	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	LINC01241	9	25804287	A	G
rs2360806	25628336	9705	ST18	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	ST18	8	52213174	A	C
rs2551802	25628336	3232	HOXD3	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	HOXD3	2	176157430	C	G
rs34311235	25628336	53353	LRP1B	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	LRP1B	2	142009864	C	T
rs34912216	25628336	221935	SDK1	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	SDK1	7	4078745	G	A
rs4343996	25628336	221935	SDK1	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	SDK1	7	3323010	G	A
rs56051278	25628336	2820	GPD2	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	GPD2	2	156525242	A	G
rs60464047	25628336	11281	POU6F2	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	POU6F2	7	39378939	T	A
rs61759167	25628336	63976	PRDM16	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	PRDM16	1	3175023	C	T
rs6946969	25628336	26053	AUTS2	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	AUTS2;LOC105375347	7	70746041	G	A
rs7170668	25628336	145820	LINC00924	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	LINC00924;LOC105370993	15	95470914	T	C
rs7957589	25628336	29951	PDZRN4	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	PDZRN4	12	41480480	A	T
rs9834560	25628336	131034	CPNE4	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	CPNE4;LOC105374112	3	131997261	C	A
rs9906289	25628336	3213	HOXB3	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	HOXB3	17	48567315	C	T
rs997295	25628336	5607	MAP2K5	umls:C0026603	GWASCAT	Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.	0.12	2015	MAP2K5	15	67724005	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0026603	nicotine	D009538	-	motion sickness	MESH:D009041	marker/mechanism	17990061

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)