All Snps(Total Genotypes:80) |
|---|
| snpId |
pubmedId |
geneId |
geneSymbol |
diseaseId |
sourceId |
sentence |
score |
Year |
geneSymbol_dbSNP |
CHROMOSOME |
POS |
REF |
ALT |
| rs1006737 | 24944871 | 160851 | DGKH | umls:C0525045 | BeFree | Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191). | 0.000271442 | 2014 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 21042317 | 775 | CACNA1C | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.002171535 | 2012 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 22957138 | 775 | CACNA1C | umls:C0525045 | BeFree | Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia as well as mood disorders. | 0.002171535 | 2012 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 21042317 | 51083 | GAL | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.000814326 | 2012 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 21042317 | 257144 | GCSAM | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.000271442 | 2012 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 24643163 | 775 | CACNA1C | umls:C0525045 | BeFree | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 0.002171535 | 2014 | CACNA1C | 12 | 2236129 | G | A |
| rs1006737 | 24643163 | 27445 | PCLO | umls:C0525045 | BeFree | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 0.000271442 | 2014 | CACNA1C | 12 | 2236129 | G | A |
| rs10994336 | 24944871 | 160851 | DGKH | umls:C0525045 | BeFree | Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191). | 0.000271442 | 2014 | ANK3 | 10 | 60420054 | C | T |
| rs1170191 | 24944871 | 160851 | DGKH | umls:C0525045 | BeFree | Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191). | 0.000271442 | 2014 | DGKH | 13 | 42101357 | A | G |
| rs147634553 | 15473915 | 3674 | ITGA2B | umls:C0525045 | BeFree | Haplotype analysis revealed a common GTA haplotype, formed by SNPs 684C/G, 1185C/T and 1832G/A, conferring risk for affective disorders. | 0.000271442 | 2005 | ITGA2B | 17 | 44383518 | G | A,T |
| rs1653625 | 23602648 | 5027 | P2RX7 | umls:C0525045 | BeFree | In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders. | 0.002985861 | 2013 | P2RX7;LOC105370032 | 12 | 121185082 | C | A |
| rs1657268 | 19381154 | 6532 | SLC6A4 | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.188499293 | 2010 | HTR5A | 7 | 155082904 | C | T |
| rs1657268 | 19381154 | 3350 | HTR1A | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.017707192 | 2010 | HTR5A | 7 | 155082904 | C | T |
| rs1800497 | 24655768 | 1813 | DRD2 | umls:C0525045 | BeFree | The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis. | 0.010358398 | 2014 | ANKK1 | 11 | 113400106 | G | A |
| rs1800532 | 21989108 | 7166 | TPH1 | umls:C0525045 | BeFree | Three hundred and ninety-eight patients diagnosed with mood disorders were genotyped for TPH1 G-6526A promoter polymorphism (rs4537731) and the A218C intron 7 polymorphism (rs1800532) and a set of ancestry informative markers, assessed for Diagnostic and Statistical Manual of Mental Disorders, 4th edition diagnoses, and assessed for a history of physical and sexual abuse. | 0.016645169 | 2012 | TPH1 | 11 | 18026269 | G | T |
| rs1801028 | 8723039 | 1813 | DRD2 | umls:C0525045 | BeFree | Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders. | 0.010358398 | 1996 | DRD2 | 11 | 113412762 | G | C |
| rs1801253 | 12815745 | 1041 | CDSN | umls:C0525045 | BeFree | A recently identified functional polymorphism in the beta(1)-adrenergic receptor (G1165C) leading to the amino acid variation Gly389Arg was associated with an enhanced coupling to the stimulatory G(s)-protein and increased adenylyl cyclase activation, disturbances which are often observed in affective disorders. | 0.000271442 | 2003 | ADRB1 | 10 | 114045297 | G | C |
| rs1801253 | 12815745 | 7448 | VTN | umls:C0525045 | BeFree | A recently identified functional polymorphism in the beta(1)-adrenergic receptor (G1165C) leading to the amino acid variation Gly389Arg was associated with an enhanced coupling to the stimulatory G(s)-protein and increased adenylyl cyclase activation, disturbances which are often observed in affective disorders. | 0.000271442 | 2003 | ADRB1 | 10 | 114045297 | G | C |
| rs1801253 | 12815745 | 153 | ADRB1 | umls:C0525045 | BeFree | A recently identified functional polymorphism in the beta(1)-adrenergic receptor (G1165C) leading to the amino acid variation Gly389Arg was associated with an enhanced coupling to the stimulatory G(s)-protein and increased adenylyl cyclase activation, disturbances which are often observed in affective disorders. | 0.000542884 | 2003 | ADRB1 | 10 | 114045297 | G | C |
| rs1805054 | 10581475 | 3362 | HTR6 | umls:C0525045 | BeFree | Association analysis of the 5-HT(6) receptor polymorphism (C267T) in mood disorders. | 0.002909916 | 1999 | HTR6 | 1 | 19666020 | C | T |
| rs181856615 | 20080186 | 56144 | PCDHA4 | umls:C0525045 | BeFree | These findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders. | 0.000542884 | 2010 | PCDHA9;PCDHA11;PCDHA10;PCDHA8;PCDHA7;PCDHA6;PCDHA5;PCDHA4;PCDHA3;PCDHA2;PCDHA1 | 5 | 140870462 | G | A |
| rs181856615 | 20080186 | 2166 | FAAH | umls:C0525045 | BeFree | These findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders. | 0.000542884 | 2010 | PCDHA9;PCDHA11;PCDHA10;PCDHA8;PCDHA7;PCDHA6;PCDHA5;PCDHA4;PCDHA3;PCDHA2;PCDHA1 | 5 | 140870462 | G | A |
| rs1997679 | 20951386 | 84062 | DTNBP1 | umls:C0525045 | BeFree | In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia. | 0.000814326 | 2011 | DTNBP1 | 6 | 15658674 | G | A |
| rs2072621 | 21565467 | 9248 | GPR50 | umls:C0525045 | BeFree | Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern. | 0.005362824 | 2012 | GPR50 | X | 151177387 | C | A |
| rs2230912 | 19330776 | 5027 | P2RX7 | umls:C0525045 | BeFree | Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders. | 0.002985861 | 2009 | P2RX7;LOC105370032 | 12 | 121184393 | A | G |
| rs2230912 | 23602648 | 5027 | P2RX7 | umls:C0525045 | BeFree | In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders. | 0.002985861 | 2013 | P2RX7;LOC105370032 | 12 | 121184393 | A | G |
| rs2230912 | 19160446 | 5027 | P2RX7 | umls:C0525045 | BeFree | Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders. | 0.002985861 | 2009 | P2RX7;LOC105370032 | 12 | 121184393 | A | G |
| rs2230912 | 24533115 | 5027 | P2RX7 | umls:C0525045 | BeFree | Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis. | 0.002985861 | 2014 | P2RX7;LOC105370032 | 12 | 121184393 | A | G |
| rs2251219 | 21042317 | 51083 | GAL | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.000814326 | 2012 | PBRM1 | 3 | 52550771 | T | C |
| rs2251219 | 20081856 | 55193 | PBRM1 | umls:C0525045 | GAD | [Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.] | 0.002367032 | 2010 | PBRM1 | 3 | 52550771 | T | C |
| rs2251219 | 21042317 | 257144 | GCSAM | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.000271442 | 2012 | PBRM1 | 3 | 52550771 | T | C |
| rs2251219 | 21042317 | 775 | CACNA1C | umls:C0525045 | BeFree | Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). | 0.002171535 | 2012 | PBRM1 | 3 | 52550771 | T | C |
| rs2522833 | 24643163 | 27445 | PCLO | umls:C0525045 | BeFree | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 0.000271442 | 2014 | PCLO | 7 | 82824392 | A | C |
| rs2522833 | 24643163 | 775 | CACNA1C | umls:C0525045 | BeFree | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 0.002171535 | 2014 | PCLO | 7 | 82824392 | A | C |
| rs3783641 | 22770721 | 2643 | GCH1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | GCH1 | 14 | 54893421 | T | A |
| rs3783641 | 22770721 | 92170 | MTG1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | GCH1 | 14 | 54893421 | T | A |
| rs3794808 | 19381154 | 6532 | SLC6A4 | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.188499293 | 2010 | SLC6A4 | 17 | 30204775 | C | T |
| rs3794808 | 19381154 | 3350 | HTR1A | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.017707192 | 2010 | SLC6A4 | 17 | 30204775 | C | T |
| rs386513644 | 20080186 | 2166 | FAAH | umls:C0525045 | BeFree | These findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders. | 0.000542884 | 2010 | NA | NA | NA | NA | NA |
| rs386513644 | 20080186 | 56144 | PCDHA4 | umls:C0525045 | BeFree | These findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders. | 0.000542884 | 2010 | NA | NA | NA | NA | NA |
| rs386602118 | 23823988 | 627 | BDNF | umls:C0525045 | BeFree | Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders. | 0.027283602 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 18450378 | 627 | BDNF | umls:C0525045 | BeFree | According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. | 0.027283602 | 2008 | NA | NA | NA | NA | NA |
| rs386602118 | 17392738 | 627 | BDNF | umls:C0525045 | BeFree | In the present study, we evaluated the impact of the BDNF Val66Met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (DAT VNTR). | 0.027283602 | 2007 | NA | NA | NA | NA | NA |
| rs386602118 | 21310593 | 627 | BDNF | umls:C0525045 | BeFree | The brain derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with affective disorders, but its role in emotion processing has not been fully established. | 0.027283602 | 2011 | NA | NA | NA | NA | NA |
| rs386602118 | 17392738 | 6532 | SLC6A4 | umls:C0525045 | BeFree | In the present study, we evaluated the impact of the BDNF Val66Met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (DAT VNTR). | 0.188499293 | 2007 | NA | NA | NA | NA | NA |
| rs386602118 | 22396415 | 627 | BDNF | umls:C0525045 | BeFree | The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is a common human single nucleotide polymorphism (SNP) that affects the regulated release of BDNF, and has been implicated in affective disorders and cognitive dysfunction. | 0.027283602 | 2012 | NA | NA | NA | NA | NA |
| rs386602118 | 19336781 | 627 | BDNF | umls:C0525045 | BeFree | Individuals with schizoaffective disorder and other affective disorders were significantly more likely to carry two copies of the most common BDNF haplotype (containing the valine allele of the Val66Met polymorphism) compared with healthy volunteers. | 0.027283602 | 2009 | NA | NA | NA | NA | NA |
| rs386602118 | 16649215 | 627 | BDNF | umls:C0525045 | BeFree | This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects. | 0.027283602 | 2006 | NA | NA | NA | NA | NA |
| rs386602118 | 18450378 | 6532 | SLC6A4 | umls:C0525045 | BeFree | Further investigations in larger samples are needed to clarify the usefulness of 5-HTTLPR and BDNF Val66Met genotyping in the optimization of non-pharmacological treatments in mood disorders. | 0.188499293 | 2008 | NA | NA | NA | NA | NA |
| rs386602118 | 22225729 | 627 | BDNF | umls:C0525045 | BeFree | The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. | 0.027283602 | 2012 | NA | NA | NA | NA | NA |
| rs386602118 | 19931400 | 627 | BDNF | umls:C0525045 | BeFree | A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. | 0.027283602 | 2010 | NA | NA | NA | NA | NA |
| rs386602276 | 10802129 | 3356 | HTR2A | umls:C0525045 | BeFree | Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese. | 0.01680699 | 2000 | NA | NA | NA | NA | NA |
| rs386602276 | 18783799 | 3356 | HTR2A | umls:C0525045 | BeFree | The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behaviour by a genetic association between the 5-HT2A T102C silent polymorphism and suicidality in patients with mood disorders and schizophrenia. | 0.01680699 | 2009 | NA | NA | NA | NA | NA |
| rs4537731 | 21989108 | 7166 | TPH1 | umls:C0525045 | BeFree | Three hundred and ninety-eight patients diagnosed with mood disorders were genotyped for TPH1 G-6526A promoter polymorphism (rs4537731) and the A218C intron 7 polymorphism (rs1800532) and a set of ancestry informative markers, assessed for Diagnostic and Statistical Manual of Mental Disorders, 4th edition diagnoses, and assessed for a history of physical and sexual abuse. | 0.016645169 | 2012 | NA | 11 | 18047335 | T | C |
| rs4680 | 25766270 | 1312 | COMT | umls:C0525045 | BeFree | Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. | 0.014168516 | 2015 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 22745815 | 1312 | COMT | umls:C0525045 | BeFree | Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. | 0.014168516 | 2012 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 18828035 | 1312 | COMT | umls:C0525045 | BeFree | No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders. | 0.014168516 | 2008 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4818 | 19699472 | 1312 | COMT | umls:C0525045 | GAD | [Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism.] | 0.014168516 | 2009 | COMT;MIR4761 | 22 | 19963684 | C | G,T |
| rs5443 | 11586049 | 2784 | GNB3 | umls:C0525045 | BeFree | The results reveal that it is not likely that the C825T polymorphism in the GNB3 gene subunit is involved in mood disorder pathogenesis. | 0.005362824 | 2001 | GNB3;CDCA3 | 12 | 6845711 | C | T |
| rs6265 | 24944871 | 160851 | DGKH | umls:C0525045 | BeFree | Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191). | 0.000271442 | 2014 | BDNF;BDNF-AS | 11 | 27658369 | C | T |
| rs6295 | 26001668 | 3350 | HTR1A | umls:C0525045 | BeFree | History of mood disorders and HTR1A G allele variation, the C-1019G polymorphism of the transcriptional control region of the 5-HT1A receptor, independently predicted the incidence of IFN-induced depression in HCV patients, whether separately or jointly considered and although not reciprocally associated. | 0.017707192 | 2015 | HTR1A | 5 | 63962738 | C | G |
| rs6296 | 19702551 | 3351 | HTR1B | umls:C0525045 | BeFree | Two common genetic polymorphisms of 5-HT(1B) receptors, G861C and C129T, have been implicated in affective disorders. | 0.003267234 | 2009 | HTR1B;LOC105377864 | 6 | 77462543 | C | G |
| rs6298 | 19702551 | 3351 | HTR1B | umls:C0525045 | BeFree | Two common genetic polymorphisms of 5-HT(1B) receptors, G861C and C129T, have been implicated in affective disorders. | 0.003267234 | 2009 | HTR1B;LOC105377864 | 6 | 77463275 | G | A |
| rs6313 | 18783799 | 3356 | HTR2A | umls:C0525045 | BeFree | The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behaviour by a genetic association between the 5-HT2A T102C silent polymorphism and suicidality in patients with mood disorders and schizophrenia. | 0.01680699 | 2009 | HTR2A | 13 | 46895805 | G | A |
| rs6313 | 10802129 | 3356 | HTR2A | umls:C0525045 | BeFree | Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese. | 0.01680699 | 2000 | HTR2A | 13 | 46895805 | G | A |
| rs6318 | 25596490 | 3358 | HTR2C | umls:C0525045 | BeFree | The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. | 0.001628651 | 2015 | HTR2C;LOC105373313 | X | 114731326 | C | G |
| rs6318 | 25596490 | 6532 | SLC6A4 | umls:C0525045 | BeFree | The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. | 0.188499293 | 2015 | HTR2C;LOC105373313 | X | 114731326 | C | G |
| rs6318 | 22764241 | 3358 | HTR2C | umls:C0525045 | BeFree | In humans, a common missense single-nucleotide change (rs6318, Cys23Ser) in the 5-HT(2C) receptor gene (HTR2C) has been associated with altered activity in vitro and with clinical mood disorders. | 0.001628651 | 2012 | HTR2C;LOC105373313 | X | 114731326 | C | G |
| rs6318 | 11526472 | 3358 | HTR2C | umls:C0525045 | BeFree | Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. | 0.001628651 | 2001 | HTR2C;LOC105373313 | X | 114731326 | C | G |
| rs662 | 25153516 | 5444 | PON1 | umls:C0525045 | BeFree | The study aimed to examine the relation between TRAP levels and PON1 activity, PON1 Q192R functional genotypes, smoking, interactions between PON1 genotypes and smoking, and mood disorders, while adjusting for effects of ethnicity, marital status, body mass index (BMI) and gender. | 0.001085767 | 2014 | PON1 | 7 | 95308134 | T | C |
| rs662 | 25037113 | 5444 | PON1 | umls:C0525045 | BeFree | Aims and methods This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. | 0.001085767 | 2015 | PON1 | 7 | 95308134 | T | C |
| rs734312 | 25074416 | 7466 | WFS1 | umls:C0525045 | BeFree | No association between wolframin gene H611R polymorphism and mood disorders: evidence from 2,570 subjects. | 0.009987267 | 2015 | WFS1 | 4 | 6301627 | G | A |
| rs734312 | 19328217 | 7466 | WFS1 | umls:C0525045 | BeFree | Wolframin gene H611R polymorphism: no direct association with suicidal behavior but possible link to mood disorders. | 0.009987267 | 2009 | WFS1 | 4 | 6301627 | G | A |
| rs8007267 | 22770721 | 2643 | GCH1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | NA | 14 | 54912273 | C | T |
| rs8007267 | 22770721 | 92170 | MTG1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | NA | 14 | 54912273 | C | T |
| rs841 | 22770721 | 2643 | GCH1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | GCH1 | 14 | 54843774 | G | A |
| rs841 | 22770721 | 92170 | MTG1 | umls:C0525045 | BeFree | Thus, we considered the GTP cyclohydrolase gene (GCH1) to be a good candidate gene in the pathophysiology of MDs and of the serotonin selective reuptake inhibitors (SSRIs) response in MDD, and conducted a case-control study utilizing three SNPs (rs8007267, rs3783641 and rs841) and moderate sample sizes (405 MDD patients, including 262 patients treated by SSRIs, 1022 BP patients and 1805 controls). | 0.000271442 | 2012 | GCH1 | 14 | 54843774 | G | A |
| rs878567 | 19381154 | 6532 | SLC6A4 | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.188499293 | 2010 | HTR1A | 5 | 63960164 | A | G |
| rs878567 | 19381154 | 3350 | HTR1A | umls:C0525045 | BeFree | Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). | 0.017707192 | 2010 | HTR1A | 5 | 63960164 | A | G |
| rs9370822 | 20951386 | 84062 | DTNBP1 | umls:C0525045 | BeFree | In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia. | 0.000814326 | 2011 | DTNBP1;LOC105374947 | 6 | 15544505 | A | C |
