PedAM

Pediatric Disease Annotations & Medicines


	miller fisher syndrome

Disease ID	619
Disease	miller fisher syndrome
Definition	A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)
Synonym	fisher miller syndrome fisher syndrome fisher's syndrome fisher's syndrome (disorder) guillain barre syndrome, miller fisher variant guillain-barre syndrome, miller fisher variant miller fisher syndrome [disease/finding] miller fisher variant of guillain barre syndrome miller-fisher syndrome miller-fisher variant of guillain-barre syndrome miller-fisher variant of guillain-barre syndrome (disorder) ophthalmoplegia, ataxia and areflexia syndrome ophthalmoplegia, ataxia, areflexia syndrome syndrome miller fisher syndrome, fisher syndrome, miller fisher syndrome, miller-fisher
Orphanet	ORPHANET:98919
DOID	DOID:12889
UMLS	C0393799
MeSH	D019846
SNOMED-CT	SNOMEDCT_US_2016_09_01:1767005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:9) C0029089 \| ophthalmoplegia \| 3 C0004134 \| ataxia \| 2 C0014038 \| encephalitis \| 1 C0154946 \| acute angle-closure glaucoma \| 1 C0015464 \| facial palsy \| 1 C0017601 \| glaucoma \| 1 C0017605 \| angle-closure glaucoma \| 1 C0015300 \| proptosis \| 1 C0021400 \| influenza \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:41) 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 55907 \| CMAS \| DISEASES 6402 \| SELL \| DISEASES 3375 \| IAPP \| DISEASES 55821 \| ALLC \| DISEASES 2581 \| GALC \| DISEASES 3093 \| UBE2K \| DISEASES 10681 \| GNB5 \| DISEASES 9172 \| MYOM2 \| DISEASES 4841 \| NONO \| DISEASES 3060 \| HCRT \| DISEASES 10085 \| EDIL3 \| DISEASES 5376 \| PMP22 \| DISEASES 6764 \| ST5 \| DISEASES 27036 \| SIGLEC7 \| DISEASES 2903 \| GRIN2A \| DISEASES 25870 \| SUMF2 \| DISEASES 124454 \| EARS2 \| DISEASES 875 \| CBS \| DISEASES 2204 \| FCAR \| DISEASES 117145 \| THEM4 \| DISEASES 4803 \| NGF \| DISEASES 959 \| CD40LG \| DISEASES 5730 \| PTGDS \| DISEASES 4593 \| MUSK \| DISEASES 7133 \| TNFRSF1B \| DISEASES 8573 \| CASK \| DISEASES 5251 \| PHEX \| DISEASES 5555 \| PRH2 \| DISEASES 4099 \| MAG \| DISEASES 2719 \| GPC3 \| DISEASES 8091 \| HMGA2 \| DISEASES 7122 \| CLDN5 \| DISEASES 146713 \| RBFOX3 \| DISEASES 4908 \| NTF3 \| DISEASES 7124 \| TNF \| DISEASES 5554 \| PRH1 \| DISEASES 11331 \| PHB2 \| DISEASES 6223 \| RPS19 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	619
Disease	miller fisher syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0000602 \| Ophthalmoplegia \| 3 HP:0001251 \| Ataxia \| 2 HP:0001284 \| Areflexia \| 1 HP:0009916 \| Asymmetric pupil sizes \| 1 HP:0000520 \| Anterior bulging of the globe of eye \| 1 HP:0000501 \| Glaucoma \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0002383 \| Encephalitis \| 1

Disease ID	619
Disease	miller fisher syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2598155 \| pain C1963184 \| nystagmus C1135207 \| ataxia C0852420 \| neuromuscular junction dysfunction C0847483 \| nerve lesion C0240991 \| sensory ataxia C0162292 \| external ophthalmoplegia C0029089 \| ophthalmoplegia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0029089 \| ophthalmoplegia \| 3 C0004134 \| ataxia \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0393799	tacrolimus	D016559	109581-93-3	miller fisher syndrome	MESH:D019846	marker/mechanism	15855240

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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