PedAM

Pediatric Disease Annotations & Medicines


	miliary tuberculosis

Disease ID	1293
Disease	miliary tuberculosis
Definition	An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.
Synonym	[x]miliary tuberculosis, unspecified [x]miliary tuberculosis, unspecified (disorder) miliary tb miliary tb nos-unspec miliary tuberculoses miliary tuberculosis (disorder) miliary tuberculosis nos miliary tuberculosis nos (disorder) miliary tuberculosis, nos miliary tuberculosis, unspecified, unspecified mtb - miliary tuberculosis tuberculoses, miliary tuberculosis, miliary tuberculosis, miliary [disease/finding] unspecified miliary tuberculosis
DOID	DOID:9861
UMLS	C0041321
MeSH	D014391
SNOMED-CT	SNOMEDCT_US_2016_09_01:47604008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:28) C0035222 \| acute respiratory distress syndrome \| 7 C1704437 \| respiratory distress syndrome \| 7 C0032326 \| pneumothorax \| 4 C0041296 \| tuberculosis \| 2 C0036202 \| sarcoidosis \| 2 C0010346 \| crohn's disease \| 2 C0020538 \| hypertension \| 2 C0032285 \| pneumonia \| 2 C0679362 \| extrapulmonary tuberculosis \| 1 C0010692 \| cystitis \| 1 C0040034 \| thrombocytopenia \| 1 C0409974 \| lupus erythematosus \| 1 C0878544 \| cardiomyopathy \| 1 C0007193 \| dilated cardiomyopathy \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0029443 \| osteomyelitis \| 1 C1565489 \| renal insufficiency \| 1 C0031039 \| pericardial effusion \| 1 C0032285 \| pneumonitis \| 1 C0030312 \| pancytopenia \| 1 C0003467 \| anxiety \| 1 C0020542 \| pulmonary hypertension \| 1 C0024312 \| lymphocytopenia \| 1 C0001623 \| adrenal insufficiency \| 1 C0024115 \| lung disease \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0029882 \| otitis media \| 1 C0949690 \| spondyloarthritis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:45) 973 \| CD79A \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 4852 \| NPY \| DISEASES 1401 \| CRP \| DISEASES 6521 \| SLC4A1 \| DISEASES 943 \| TNFRSF8 \| DISEASES 941 \| CD80 \| DISEASES 5443 \| POMC \| DISEASES 7535 \| ZAP70 \| DISEASES 4885 \| NPTX2 \| DISEASES 27163 \| NAAA \| DISEASES 1636 \| ACE \| DISEASES 6285 \| S100B \| DISEASES 114757 \| CYGB \| DISEASES 213 \| ALB \| DISEASES 7399 \| USH2A \| DISEASES 6504 \| SLAMF1 \| DISEASES 23592 \| LEMD3 \| DISEASES 1555 \| CYP2B6 \| DISEASES 9146 \| HGS \| DISEASES 682 \| BSG \| DISEASES 23583 \| SMUG1 \| DISEASES 3266 \| ERAS \| DISEASES 3329 \| HSPD1 \| DISEASES 3683 \| ITGAL \| DISEASES 1805 \| DPT \| DISEASES 1520 \| CTSS \| DISEASES 959 \| CD40LG \| DISEASES 80712 \| ESX1 \| DISEASES 2833 \| CXCR3 \| DISEASES 94027 \| CGB7 \| DISEASES 7905 \| REEP5 \| DISEASES 54790 \| TET2 \| DISEASES 551 \| AVP \| DISEASES 5214 \| PFKP \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 60489 \| APOBEC3G \| DISEASES 7124 \| TNF \| DISEASES 7072 \| TIA1 \| DISEASES 94115 \| CGB8 \| DISEASES 5158 \| PDE6B \| DISEASES 727897 \| MUC5B \| DISEASES 246734 \| NPCDR1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1293
Disease	miliary tuberculosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0002098 \| Respiratory distress \| 6 HP:0002107 \| Collapsed lung \| 4 HP:0100280 \| Morbus Crohn \| 2 HP:0002090 \| Pneumonia \| 2 HP:0001945 \| Fever \| 2 HP:0000822 \| Hypertension \| 2 HP:0002108 \| Spontaneous pneumothorax \| 2 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0000846 \| Hypoadrenalism \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0001644 \| Congestive cardiomyopathy \| 1 HP:0002091 \| Restrictive ventilatory defect \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0000739 \| Anxiety \| 1 HP:0000388 \| Otitis media \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0001888 \| Lymphocytopenia \| 1 HP:0001873 \| Low platelet count \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002754 \| Bone infection \| 1

Disease ID	1293
Disease	miliary tuberculosis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0035222 \| acute respiratory distress syndrome \| 6 C0032326 \| pneumothorax \| 4 C0041295 \| tuberculoma \| 4 C0032285 \| pneumonia \| 2 C0149781 \| spontaneous pneumothorax \| 2 C2362319 \| acute respiratory distress syndrome (ards) \| 1 C0030312 \| pancytopenia \| 1 C0040034 \| thrombocytopenia \| 1 C0876991 \| hemophagocytosis \| 1 C0010692 \| cystitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs17235409	16461017	6556	SLC11A1	umls:C0041321	BeFree	No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P=0.08) was suggested.	0.000271442	2006	SLC11A1	2	218395009	G	A,C
rs3804099	17554342	7097	TLR2	umls:C0041321	BeFree	These results demonstrate a strong association of TLR2 SNP T597C with the development of TBM and miliary TB and indicate that TLR2 influences the dissemination of M. tuberculosis.	0.000271442	2007	TLR2	4	153703504	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0041321	ethambutol	D004977	74-55-5	tuberculosis, miliary	MESH:D014391	therapeutic	18709970

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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