PedAM

Pediatric Disease Annotations & Medicines


	migraine with aura

Disease ID	661
Disease	migraine with aura
Definition	A migraine disorder characterized by episodes that are preceded by focal neurological symptoms.
Synonym	aura migraine aura migraines auras migraines classic migraine classic migraines classical migraine migraine aura migraine auras migraine classical migraine preceded or accompanied by transient focal neurological phenomena migraine with aura (disorder) migraine with aura [disease/finding] migraine with auras
DOID	DOID:10024
UMLS	C0154723
MeSH	D020325
SNOMED-CT	SNOMEDCT_US_2016_09_01:4473006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C0154723 \| migraine with aura \| 316 C0149931 \| migraine \| 285 C0011570 \| depression \| 5 C1735856 \| classic migraine \| 3 C0007222 \| cardiovascular disease \| 2 C0338480 \| migraine without aura \| 2 C0042373 \| vascular disease \| 2 C0027765 \| neurological disorders \| 1 C0020538 \| hypertension \| 1 C0155626 \| acute mi \| 1 C0042075 \| urological disorders \| 1 C0027765 \| neurological disorder \| 1 C0016522 \| patent foramen ovale \| 1 C0024623 \| gastric cancer \| 1 C0036341 \| schizophrenia \| 1 C0338480 \| common migraine \| 1 C0002986 \| fabry disease \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0035258 \| restless legs syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) ATP1A2 \| 477 \| GHR SCN1A \| 6323 \| GHR CACNA1A \| 773 \| GHR PRRT2 \| 112476 \| GHR NEDD4L \| 23327 \| GWASCAT TRPM8 \| 79054 \| GWASCAT VSTM4 \| 196740 \| GWASCAT ADARB2 \| 105 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:24) 1636 \| ACE \| infer 477 \| ATP1A2 \| infer 773 \| CACNA1A \| infer 777 \| CACNA1E \| infer 54897 \| CASZ1 \| infer 1621 \| DBH \| infer 1813 \| DRD2 \| infer 1909 \| EDNRA \| infer 1910 \| EDNRB \| infer 2099 \| ESR1 \| infer 356 \| FASLG \| infer 2558 \| GABRA5 \| infer 3351 \| HTR1B \| infer 3352 \| HTR1D \| infer 3356 \| HTR2A \| infer 3358 \| HTR2C \| infer 3643 \| INSR \| infer 3766 \| KCNJ10 \| infer 3765 \| KCNJ9 \| infer 4524 \| MTHFR \| infer 4538 \| MT-ND4 \| infer 4846 \| NOS3 \| infer 6531 \| SLC6A3 \| infer 6532 \| SLC6A4 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:141) 100506492 \| DSCAM-AS1 \| DISEASES 1815 \| DRD4 \| DISEASES 53405 \| CLIC5 \| DISEASES 2099 \| ESR1 \| DISEASES 10627 \| MYL12A \| DISEASES 55512 \| SMPD3 \| DISEASES 6804 \| STX1A \| DISEASES 4619 \| MYH1 \| DISEASES 116449 \| CLNK \| DISEASES 24145 \| PANX1 \| DISEASES 41 \| ASIC1 \| DISEASES 103910 \| MYL12B \| DISEASES 3218 \| HOXB8 \| DISEASES 5300 \| PIN1 \| DISEASES 8220 \| DGCR14 \| DISEASES 5589 \| PRKCSH \| DISEASES 8864 \| PER2 \| DISEASES 10267 \| RAMP1 \| DISEASES 1401 \| CRP \| DISEASES 10955 \| SERINC3 \| DISEASES 3357 \| HTR2B \| DISEASES 51719 \| CAB39 \| DISEASES 4836 \| NMT1 \| DISEASES 1419 \| CRYGB \| DISEASES 6532 \| SLC6A4 \| DISEASES 9914 \| ATP2C2 \| DISEASES 443 \| ASPA \| DISEASES 5024 \| P2RX3 \| DISEASES 4854 \| NOTCH3 \| DISEASES 2892 \| GRIA3 \| DISEASES 4552 \| MTRR \| DISEASES 64083 \| GOLPH3 \| DISEASES 1181 \| CLCN2 \| DISEASES 775 \| CACNA1C \| DISEASES 6895 \| TARBP2 \| DISEASES 8620 \| NPFF \| DISEASES 3705 \| ITPK1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 63976 \| PRDM16 \| DISEASES 3782 \| KCNN3 \| DISEASES 25953 \| PNKD \| DISEASES 3358 \| HTR2C \| DISEASES 7564 \| ZNF16 \| DISEASES 288 \| ANK3 \| DISEASES 6326 \| SCN2A \| DISEASES 23250 \| ATP11A \| DISEASES 2890 \| GRIA1 \| DISEASES 4325 \| MMP16 \| DISEASES 54102 \| CLIC6 \| DISEASES 57369 \| GJD2 \| DISEASES 1636 \| ACE \| DISEASES 8209 \| C21orf33 \| DISEASES 3060 \| HCRT \| DISEASES 57465 \| TBC1D24 \| DISEASES 476 \| ATP1A1 \| DISEASES 5196 \| PF4 \| DISEASES 54859 \| ELP6 \| DISEASES 4846 \| NOS3 \| DISEASES 7001 \| PRDX2 \| DISEASES 1632 \| ECI1 \| DISEASES 51305 \| KCNK9 \| DISEASES 478 \| ATP1A3 \| DISEASES 9196 \| KCNAB3 \| DISEASES 6323 \| SCN1A \| DISEASES 3643 \| INSR \| DISEASES 3790 \| KCNS3 \| DISEASES 2353 \| FOS \| DISEASES 435 \| ASL \| DISEASES 2147 \| F2 \| DISEASES 3265 \| HRAS \| DISEASES 54207 \| KCNK10 \| DISEASES 93107 \| KCNG4 \| DISEASES 4281 \| MID1 \| DISEASES 5062 \| PAK2 \| DISEASES 1909 \| EDNRA \| DISEASES 783 \| CACNB2 \| DISEASES 6863 \| TAC1 \| DISEASES 10229 \| COQ7 \| DISEASES 79054 \| TRPM8 \| DISEASES 8204 \| NRIP1 \| DISEASES 56660 \| KCNK12 \| DISEASES 6331 \| SCN5A \| DISEASES 221692 \| PHACTR1 \| DISEASES 57419 \| SLC24A3 \| DISEASES 338567 \| KCNK18 \| DISEASES 3363 \| HTR7 \| DISEASES 4128 \| MAOA \| DISEASES 5828 \| PEX2 \| DISEASES 112476 \| PRRT2 \| DISEASES 8913 \| CACNA1G \| DISEASES 8021 \| NUP214 \| DISEASES 773 \| CACNA1A \| DISEASES 1284 \| COL4A2 \| DISEASES 477 \| ATP1A2 \| DISEASES 1312 \| COMT \| DISEASES 916 \| CD3E \| DISEASES 10781 \| ZNF266 \| DISEASES 1813 \| DRD2 \| DISEASES 23038 \| WDTC1 \| DISEASES 4548 \| MTR \| DISEASES 3775 \| KCNK1 \| DISEASES 777 \| CACNA1E \| DISEASES 844 \| CASQ1 \| DISEASES 480 \| ATP1A4 \| DISEASES 3765 \| KCNJ9 \| DISEASES 3766 \| KCNJ10 \| DISEASES 23376 \| UFL1 \| DISEASES 10100 \| TSPAN2 \| DISEASES 3351 \| HTR1B \| DISEASES 3062 \| HCRTR2 \| DISEASES 6015 \| RING1 \| DISEASES 4855 \| NOTCH4 \| DISEASES 4524 \| MTHFR \| DISEASES 8573 \| CASK \| DISEASES 57380 \| MRS2 \| DISEASES 170302 \| ARX \| DISEASES 1906 \| EDN1 \| DISEASES 114899 \| C1QTNF3 \| DISEASES 1814 \| DRD3 \| DISEASES 1621 \| DBH \| DISEASES 145270 \| PRIMA1 \| DISEASES 50801 \| KCNK4 \| DISEASES 4784 \| NFIX \| DISEASES 23365 \| ARHGEF12 \| DISEASES 594857 \| NPS \| DISEASES 7442 \| TRPV1 \| DISEASES 6335 \| SCN9A \| DISEASES 11277 \| TREX1 \| DISEASES 3776 \| KCNK2 \| DISEASES 57506 \| MAVS \| DISEASES 4049 \| LTA \| DISEASES 2900 \| GRIK4 \| DISEASES 9312 \| KCNB2 \| DISEASES 123041 \| SLC24A4 \| DISEASES 785 \| CACNB4 \| DISEASES 10198 \| MPHOSPH9 \| DISEASES 4522 \| MTHFD1 \| DISEASES 162514 \| TRPV3 \| DISEASES 102723508 \| KANTR \| DISEASES 104564225 \| MHRT \| DISEASES 4553 \| MT-TA \| DISEASES
Locus	(Waiting for update.)

Disease ID	661
Disease	migraine with aura
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:16) HP:0002077 \| Migraine with aura \| 316 HP:0002076 \| Migraine headaches \| 285 HP:0002315 \| Headaches \| 6 HP:0001297 \| Cerebral vascular events \| 6 HP:0000716 \| Depression \| 5 HP:0002140 \| Ischemic stroke \| 2 HP:0002083 \| Migraine without aura \| 2 HP:0012531 \| Pain \| 2 HP:0002647 \| Aortic dissection \| 1 HP:0001250 \| Seizures \| 1 HP:0000822 \| Hypertension \| 1 HP:0100753 \| Schizophrenia \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0001655 \| Patent foramen ovale \| 1 HP:0001694 \| Right-to-left shunt \| 1 HP:0002321 \| Vertigo \| 1

Disease ID	661
Disease	migraine with aura
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0018681 \| headache \| 5 C0235169 \| excitability \| 2 C0016522 \| patent foramen ovale \| 1 C0036572 \| seizures \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:53)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs104894561	23636092	1453	CSNK1D	umls:C0154723	BeFree	CKIδ-T44A mice also exhibited a reduced threshold for cortical spreading depression (believed to be the physiological analog of migraine aura) and greater arterial dilation during cortical spreading depression.	0.000271442	2014	CSNK1D	17	82265743	T	C
rs11172113	24852292	4035	LRP1	umls:C0154723	BeFree	Five loci met stringent significance for association with migraine, among which four were selective for sub-classified migraine, including rs11172113 (LRP1) for MO.	0.000271442	2014	LRP1	12	57133500	T	C
rs12273363	24708359	627	BDNF	umls:C0154723	BeFree	Five SNPs in the BDNF locus (rs1519480, rs6265, rs712507, rs2049046, and rs12273363) were genotyped initially in a cohort of 277 migraine cases, including 172 diagnosed with migraine with aura (MA) and 105 with migraine without aura (MO), and 277 age- and sex-matched controls.	0.000271442	2014	BDNF	11	27723312	T	C
rs12454023	23793025	23327	NEDD4L	umls:C0154723	GWASCAT	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	0.12	2013	NEDD4L	18	58342372	C	T
rs1519480	24708359	627	BDNF	umls:C0154723	BeFree	Five SNPs in the BDNF locus (rs1519480, rs6265, rs712507, rs2049046, and rs12273363) were genotyped initially in a cohort of 277 migraine cases, including 172 diagnosed with migraine with aura (MA) and 105 with migraine without aura (MO), and 277 age- and sex-matched controls.	0.000271442	2014	BDNF-AS	11	27654165	C	T
rs1799864	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	CCR2	3	46357717	G	A
rs1799864	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	CCR2	3	46357717	G	A
rs1799864	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	CCR2	3	46357717	G	A
rs1799864	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	CCR2	3	46357717	G	A
rs1799864	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	CCR2	3	46357717	G	A
rs1799971	22752568	4988	OPRM1	umls:C0154723	BeFree	The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a clinical cohort of female migraine with aura patients.	0.000271442	2012	OPRM1	6	154039662	A	G
rs1799983	17115991	4846	NOS3	umls:C0154723	BeFree	Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura.	0.002638474	2006	NOS3	7	150999023	T	G
rs1800469	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TGFB1;B9D2	19	41354391	A	G
rs1800469	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	TGFB1;B9D2	19	41354391	A	G
rs1800469	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TGFB1;B9D2	19	41354391	A	G
rs1800469	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TGFB1;B9D2	19	41354391	A	G
rs1800469	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TGFB1;B9D2	19	41354391	A	G
rs1800629	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	TNF	6	31575254	G	A
rs1800629	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575254	G	A
rs1800629	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575254	G	A
rs1800629	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575254	G	A
rs1800629	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575254	G	A
rs1800750	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575186	G	A
rs1800750	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575186	G	A
rs1800750	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	TNF	6	31575186	G	A
rs1800750	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575186	G	A
rs1800750	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	TNF	6	31575186	G	A
rs2049046	24708359	627	BDNF	umls:C0154723	BeFree	Five SNPs in the BDNF locus (rs1519480, rs6265, rs712507, rs2049046, and rs12273363) were genotyped initially in a cohort of 277 migraine cases, including 172 diagnosed with migraine with aura (MA) and 105 with migraine without aura (MO), and 277 age- and sex-matched controls.	0.000271442	2014	BDNF	11	27702228	T	A
rs2069885	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	IL9	5	135892476	G	A
rs2069885	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	IL9	5	135892476	G	A
rs2069885	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	IL9	5	135892476	G	A
rs2069885	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	IL9	5	135892476	G	A
rs2069885	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	IL9	5	135892476	G	A
rs2137920	23793025	196740	VSTM4	umls:C0154723	GWASCAT	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	0.12	2013	VSTM4	10	49021593	T	A
rs222741	22162417	7442	TRPV1	umls:C0154723	BeFree	In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group.	0.000271442	2012	TRPV1	17	3605586	G	A
rs222741	22162417	162514	TRPV3	umls:C0154723	BeFree	In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group.	0.000271442	2012	TRPV1	17	3605586	G	A
rs2234693	22511967	2099	ESR1	umls:C0154723	BeFree	Out of four ESR1 polymorphisms, only rs2234693 variant allele was significantly associated in migraine with aura.	0.003181358	2012	ESR1	6	151842200	T	C
rs2820651	23793025	105	ADARB2	umls:C0154723	GWASCAT	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	0.12	2013	ADARB2	10	1429570	C	A
rs386596107	25295643	6648	SOD2	umls:C0154723	BeFree	Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?	0.000271442	2015	NA	NA	NA	NA	NA
rs3918226	19559392	7124	TNF	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000542884	2009	NOS3	7	150993088	C	T
rs3918226	19559392	3578	IL9	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	NOS3	7	150993088	C	T
rs3918226	19559392	7040	TGFB1	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	NOS3	7	150993088	C	T
rs3918226	19559392	729230	CCR2	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	NOS3	7	150993088	C	T
rs3918226	19559392	342977	NANOS3	umls:C0154723	BeFree	Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885.	0.000271442	2009	NOS3	7	150993088	C	T
rs41276886	20080591	773	CACNA1A	umls:C0154723	BeFree	We now report on a mutation identified in the first intracellular loop of CACNA1A (alpha(1A(A454T))) that does not cause FHM but is associated with the absence of sensorimotor symptoms in a migraine with aura pedigree.	0.016435859	2010	CACNA1A	19	13317310	C	T
rs4880	25295643	6648	SOD2	umls:C0154723	BeFree	Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?	0.000271442	2015	SOD2	6	159692840	A	G
rs6265	24708359	627	BDNF	umls:C0154723	BeFree	Five SNPs in the BDNF locus (rs1519480, rs6265, rs712507, rs2049046, and rs12273363) were genotyped initially in a cohort of 277 migraine cases, including 172 diagnosed with migraine with aura (MA) and 105 with migraine without aura (MO), and 277 age- and sex-matched controls.	0.000271442	2014	BDNF;BDNF-AS	11	27658369	C	T
rs6318	17901921	3358	HTR2C	umls:C0154723	BeFree	Our study did not confirm the HTR2C Cys23Ser polymorphism as a risk factor for migraine and MA.	0.008630058	2007	HTR2C;LOC105373313	X	114731326	C	G
rs6318	15147464	3358	HTR2C	umls:C0154723	BeFree	The present study provides that 5HTR2c Cys23Ser polymorphism may be associated with MWA in Japanese population.	0.008630058	2004	HTR2C;LOC105373313	X	114731326	C	G
rs6741751	23793025	79054	TRPM8	umls:C0154723	GWASCAT	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	0.12	2013	TRPM8	2	233919016	G	A
rs712507	24708359	627	BDNF	umls:C0154723	BeFree	Five SNPs in the BDNF locus (rs1519480, rs6265, rs712507, rs2049046, and rs12273363) were genotyped initially in a cohort of 277 migraine cases, including 172 diagnosed with migraine with aura (MA) and 105 with migraine without aura (MO), and 277 age- and sex-matched controls.	0.000271442	2014	PHLDB2	3	111936542	T	C
rs7217270	22162417	7442	TRPV1	umls:C0154723	BeFree	In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group.	0.000271442	2012	TRPV3	17	3518181	A	G
rs7217270	22162417	162514	TRPV3	umls:C0154723	BeFree	In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group.	0.000271442	2012	TRPV3	17	3518181	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:41)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	3083712	rs2651899	T	C	rs2651899	23793025	2.54E-04	NA	NA	NA	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	PRDM16
1	4183006	rs10915437	A	G	rs10915437	23793025	1.56E-04	NA	1.11	[0.86-0.95]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	NA
1	5661009	rs7528859	T	A	rs7528859	23793025	5.00E-06	NA	1.12	[1.07-1.18]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs7528859-A	Meta-Analysis	A	NA
1	115677946	rs12134493	C	A	rs12134493	23793025	6.19E-04	NA	1.13	[1.05-1.21]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs12134493-A	Meta-Analysis	C	NA
1	246223120	rs6693295	C	T	rs6693295	23793025	6.00E-06	NA	1.14	[1.08-1.21]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs6693295-T	Meta-Analysis	T	SMYD3
2	234825093	rs10166942	T	C	rs10166942	23793025	1.69E-06	NA	NA	NA	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	NA
2	234827661	rs6741751	G	A	rs6741751	23793025	1.00E-07	NA	1.23	[1.14-1.33]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	TRPM8
3	71464335	rs13063872	G	A	rs13063872	23793025	3.62E-05	NA	1.22	[0.75-0.90]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	FOXP1
4	41639516	rs4345220	A	G	rs4345220	23793025	2.00E-06	NA	1.15	[1.09-1.20]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	LIMCH1
5	127716567	rs17608902	C	A	rs17608902	23793025	9.00E-06	NA	1.19	[1.10-1.28]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs17608902-A	Meta-Analysis	C	FBN2
5	142899801	rs12153243	A	T	rs12153243	23793025	3.66E-04	NA	1.09	[1.04-1.14]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs12153243-T	Meta-Analysis	A	NA
6	131446791	rs602848	C	G	rs602848	23793025	5.00E-06	NA	1.16	[1.09-1.24]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs602848-C	Meta-Analysis	G	NA
7	15758000	rs2159222	A	T	rs2159222	23793025	8.00E-06	NA	1.16	[1.09-1.23]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	NA
7	136584363	rs1364402	T	C	rs1364402	23793025	4.00E-06	NA	1.19	[1.11-1.28]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	T	CHRM2
8	20967551	rs7015657	C	G	rs7015657	23793025	8.00E-08	NA	1.15	[1.09-1.21]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs7015657-G	Meta-Analysis	G	NA
8	24044301	rs11777116	C	T	rs11777116	23793025	5.36E-05	NA	1.19	[1.09-1.30]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs11777116-T	Meta-Analysis	C	NA
8	56599777	rs4738393	G	A	rs4738393	23793025	2.03E-04	NA	1.12	[0.84-0.95]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	NA
8	98166913	rs1835740	T	C	rs1835740	23793025	1.49E-04	NA	NA	NA	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	NA
9	73094535	rs963265	T	C	rs963265	23793025	1.00E-06	NA	1.12	[1.08-1.18]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	NA
9	99132044	rs10820447	C	T	rs10820447	23793025	6.00E-06	NA	1.16	[1.09-1.23]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs10820447-T	Meta-Analysis	C	SLC35D2
10	1471765	rs2820651	C	A	rs2820651	23793025	4.00E-07	NA	1.22	[1.13-1.31]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs2820651-A	Meta-Analysis	G	ADARB2
10	6924444	rs11816922	C	A	rs11816922	23793025	2.06E-04	NA	1.17	[1.08-1.27]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs11816922-A	Meta-Analysis	C	NA
10	8091377	rs1244181	A	C,G,T	rs1244181	23793025	1.71E-06	NA	1.15	[0.82-0.92]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	NA
10	29364697	rs10826566	G	A	rs10826566	23793025	4.00E-06	NA	1.16	[1.09-1.23]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs10826566-A	Meta-Analysis	G	NA
10	30087359	rs2986961	C	T	rs2986961	23793025	5.00E-07	NA	1.14	[1.08-1.20]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs2986961-C	Meta-Analysis	C	NA
10	50229638	rs2137920	T	A	rs2137920	23793025	1.00E-06	NA	1.15	[1.09-1.22]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs2137920-T	Meta-Analysis	T	VSTM4
10	97196978	rs2274491	T	A	rs2274491	23793025	7.88E-04	NA	1.09	[0.88-0.97]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	SORBS1
10	117973597	rs12413355	A	G	rs12413355	23793025	3.00E-06	NA	1.14	[1.08-1.19]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	GFRA1
11	10673739	rs4909945	T	C	rs4909945	23793025	1.22E-04	NA	1.1	[0.87-0.95]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	MRVI1
12	4523456	rs10849061	C	T	rs10849061	23793025	2.83E-04	NA	1.09	[0.88-0.96]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	NA
12	47771429	rs2074193	T	G	rs2074193	23793025	5.00E-07	NA	1.15	[1.09-1.21]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs2074193-C	Meta-Analysis	G	NA
12	57527283	rs11172113	T	C	rs11172113	23793025	1.11E-05	NA	NA	NA	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	LRP1
12	101151475	rs10778070	C	A	rs10778070	23793025	5.88E-04	NA	1.09	[0.88-0.96]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	NA
12	118272871	rs2723279	C	A	rs2723279	23793025	9.60E-05	NA	1.11	[0.86-0.95]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	KSR2
13	35768789	rs17051917	C	T	rs17051917	23793025	9.00E-06	NA	1.19	[1.10-1.28]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	T	NBEA
15	70634709	rs11072158	A	C,T	rs11072158	23793025	3.00E-06	NA	1.18	[1.10-1.27]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	T	NA
18	44860264	rs9947662	G	A	rs9947662	23793025	8.44E-04	NA	1.09	[0.87-0.96]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	G	NA
18	46336702	rs7227892	A	T	rs7227892	23793025	2.00E-06	NA	1.14	[1.08-1.19]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	CTIF
18	56009604	rs12454023	C	T	rs12454023	23793025	8.00E-07	NA	1.12	[1.08-1.18]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	C	NEDD4L
19	39174332	rs973009	G	A	rs973009	23793025	4.00E-06	NA	1.18	[1.10-1.27]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	NA	Meta-Analysis	A	ACTN4
22	32832874	rs2076054	C	T	rs2076054	23793025	8.00E-06	NA	1.12	[1.07-1.18]	5,118 European ancestry cases; 74,239 European ancestry controls	European(79357)	ALL(79357)	EUR(79357)	ALL(79357)	Migraine with aura	HPOID:0002077	Migraine with aura	DOID:10024	migraine with aura	NA	NA	NA	NA	Migraine	rs2076054-C	Meta-Analysis	T	BPIFC

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0154723	fluoxetine	D005473	54910-89-3	migraine with aura	MESH:D020325	marker/mechanism	8331094
C0154723	propranolol	D011433	525-66-6	migraine with aura	MESH:D020325	therapeutic	10759905
C0154723	tacrolimus	D016559	109581-93-3	migraine with aura	MESH:D020325	marker/mechanism	15836601

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)