PedAM

Pediatric Disease Annotations & Medicines


	middle cerebral artery infarction

Disease ID	1280
Disease	middle cerebral artery infarction
Definition	NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Synonym	cerebral infarct middle cerebral artery cerebral infarction, middle cerebral artery infarct mca infarction, middle cerebral artery infarction, middle cerebral artery [disease/finding] mca infarct mca infarction middle cerebral artery circ infarct middle cerebral artery circulation infarction middle cerebral artery infarct middle cerebral artery stroke stroke, middle cerebral artery
DOID	DOID:3525
UMLS	C0740392
MeSH	D020244
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:10) C0338585 \| carotid artery dissection \| 1 C1527311 \| brain edema \| 1 C0032001 \| pituitary apoplexy \| 1 C0026654 \| moyamoya disease \| 1 C0026654 \| moyamoya \| 1 C0014068 \| encephalomalacia \| 1 C0018991 \| hemiplegia \| 1 C0007787 \| transient cerebral ischemia \| 1 C0007785 \| cerebral ischemia \| 1 C0003537 \| aphasia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:25) IL6 \| 3569 \| CTD_human JUNB \| 3726 \| CTD_human SOD2 \| 6648 \| CTD_human ICAM1 \| 3383 \| CTD_human STAT3 \| 6774 \| CTD_human PLAU \| 5328 \| CTD_human XDH \| 7498 \| CTD_human CXCL2 \| 2920 \| CTD_human CCL2 \| 6347 \| CTD_human EDN1 \| 1906 \| CTD_human PLAT \| 5327 \| CTD_human MMP9 \| 4318 \| CTD_human HSPD1 \| 3329 \| CTD_human FOS \| 2353 \| CTD_human ALOX5 \| 240 \| CTD_human C3 \| 718 \| CTD_human NGF \| 4803 \| CTD_human IL6ST \| 3572 \| CTD_human ATF3 \| 467 \| CTD_human SERPINH1 \| 871 \| CTD_human CCL7 \| 6354 \| CTD_human ADORA1 \| 134 \| CTD_human SPHK2 \| 56848 \| CTD_human PLD1 \| 5337 \| CTD_human TNFAIP6 \| 7130 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1636 \| ACE \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:26) 7076 \| TIMP1 \| DISEASES 5327 \| PLAT \| DISEASES 2026 \| ENO2 \| DISEASES 7035 \| TFPI \| DISEASES 6117 \| RPA1 \| DISEASES 10894 \| LYVE1 \| DISEASES 10312 \| TCIRG1 \| DISEASES 3934 \| LCN2 \| DISEASES 4319 \| MMP10 \| DISEASES 6285 \| S100B \| DISEASES 3489 \| IGFBP6 \| DISEASES 5340 \| PLG \| DISEASES 4312 \| MMP1 \| DISEASES 3052 \| HCCS \| DISEASES 10871 \| CD300C \| DISEASES 5154 \| PDGFA \| DISEASES 2547 \| XRCC6 \| DISEASES 6391 \| SDHC \| DISEASES 4318 \| MMP9 \| DISEASES 1025 \| CDK9 \| DISEASES 2155 \| F7 \| DISEASES 57380 \| MRS2 \| DISEASES 427 \| ASAH1 \| DISEASES 9842 \| PLEKHM1 \| DISEASES 6949 \| TCOF1 \| DISEASES 56342 \| PPAN \| DISEASES
Locus	(Waiting for update.)

Disease ID	1280
Disease	middle cerebral artery infarction
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0000969 \| Dropsy \| 4 HP:0002637 \| Brain ischemia \| 1 HP:0002301 \| Hemiplegia \| 1 HP:0002381 \| Aphasia \| 1 HP:0002181 \| Cerebral edema \| 1 HP:0012158 \| Carotid artery dissection \| 1 HP:0001269 \| Hemiparesis \| 1 HP:0012162 \| Common carotid artery dissection \| 1 HP:0002018 \| Nausea \| 1 HP:0040197 \| Encephalomalacia \| 1

Disease ID	1280
Disease	middle cerebral artery infarction
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C1527311 \| brain edema \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0740392	amphetamine	D000661	300-62-9	infarction, middle cerebral artery	MESH:D020244	marker/mechanism	17689416
C0740392	gemcitabine	C056507	103882-84-4	infarction, middle cerebral artery	MESH:D020244	therapeutic	19427843
C0740392	nortriptyline	D009661	72-69-5	infarction, middle cerebral artery	MESH:D020244	therapeutic	18174477
C0740392	progesterone	D011374	57-83-0	infarction, middle cerebral artery	MESH:D020244	therapeutic	15869954
C0740392	rosiglitazone	C089730	-	infarction, middle cerebral artery	MESH:D020244	therapeutic	16034372

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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