PedAM

Pediatric Disease Annotations & Medicines


	microscopic polyangiitis

Disease ID	218
Disease	microscopic polyangiitis
Definition	A systemic necrotizing vasculitis that typically affects the small and medium-sized muscular arteries. In some cases, however, microscopic vessels are also affected (e.g., in the kidneys), a condition that has been called microscopic polyarteritis or polyangiitis; this disorder is felt to be more closely associated with Wegener granulomatosis than to classic polyarteritis nodosa.
Synonym	microscopic polyangiitides microscopic polyangiitis [disease/finding] microscopic polyarteritis microscopic polyarteritis nodosa microscopic polyarteritis nodosa (disorder) polyangiitides, microscopic polyangiitis, microscopic polyarteritis nodosa microscopic
Orphanet	ORPHANET:727
ICD10	ICD10CM:M31.7
UMLS	C2347126
MeSH	D055953
SNOMED-CT	SNOMEDCT_US_2016_09_01:239928004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:41) C0034069 \| pulmonary fibrosis \| 9 C0042384 \| vasculitis \| 4 C0017658 \| glomerulonephritis \| 3 C0008312 \| biliary cirrhosis \| 2 C0019158 \| hepatitis \| 2 C0023890 \| cirrhosis \| 2 C0013990 \| emphysema \| 2 C0008312 \| primary biliary cirrhosis \| 2 C0008728 \| churg-strauss syndrome \| 2 C0152025 \| polyneuropathy \| 1 C0003864 \| arthritis \| 1 C0036421 \| systemic sclerosis \| 1 C0442874 \| neuropathy \| 1 C0040053 \| thrombus \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0007785 \| cerebral infarction \| 1 C0040053 \| thrombosis \| 1 C0024143 \| lupus nephritis \| 1 C1800706 \| idiopathic pulmonary fibrosis \| 1 C0034050 \| pulmonary alveolar proteinosis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0042769 \| virus infection \| 1 C0019196 \| hepatitis c \| 1 C0034065 \| pulmonary embolism \| 1 C0007785 \| cerebral infarct \| 1 C0043092 \| wegener's granulomatosis \| 1 C0039483 \| giant cell arteritis \| 1 C0014121 \| bacterial endocarditis \| 1 C0037116 \| silicosis \| 1 C0034050 \| alveolar proteinosis \| 1 C0002878 \| hemolytic anemia \| 1 C0003504 \| aortic valve insufficiency \| 1 C0010051 \| coronary aneurysm \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C0026934 \| mycoplasma \| 1 C0241910 \| autoimmune hepatitis \| 1 C0028866 \| oculomotor nerve palsy \| 1 C0042373 \| vascular disease \| 1 C0019196 \| hepatitis c infection \| 1 C0032285 \| pneumonitis \| 1 C0027697 \| nephritis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 3123 \| HLA-DRB1 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	218
Disease	microscopic polyangiitis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:37) HP:0011675 \| Arrhythmia HP:0100534 \| Episcleritis HP:0002239 \| Gastrointestinal hemorrhage HP:0002829 \| Arthralgia HP:0001635 \| Congestive heart failure HP:0000988 \| Skin rash HP:0100820 \| Glomerulopathy HP:0002014 \| Diarrhea HP:0009830 \| Peripheral neuropathy HP:0002960 \| Autoimmunity HP:0003326 \| Myalgia HP:0001945 \| Fever HP:0004936 \| Venous thrombosis HP:0100758 \| Gangrene HP:0000083 \| Renal insufficiency HP:0001933 \| Subcutaneous hemorrhage HP:0000246 \| Sinusitis HP:0002105 \| Hemoptysis HP:0200042 \| Skin ulcer HP:0002633 \| Vasculitis HP:0000790 \| Hematuria HP:0000421 \| Epistaxis HP:0000554 \| Uveitis HP:0001369 \| Arthritis HP:0001701 \| Pericarditis HP:0001733 \| Pancreatitis HP:0002017 \| Nausea and vomiting HP:0100520 \| Oliguria HP:0005244 \| Gastrointestinal infarctions HP:0002586 \| Peritonitis HP:0012649 \| Increased inflammatory response HP:0008046 \| Abnormality of the retinal vasculature HP:0000965 \| Cutis marmorata HP:0001482 \| Subcutaneous nodule HP:0003401 \| Paresthesia HP:0002027 \| Abdominal pain HP:0010783 \| Erythema
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0002955 \| Granulomatosis \| 33 HP:0002206 \| Pulmonary fibrosis \| 9 HP:0002617 \| Aneurysmal dilatation \| 4 HP:0002633 \| Vasculitis \| 4 HP:0000099 \| Glomerular nephritis \| 3 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0002097 \| Pulmonary emphysema \| 2 HP:0002613 \| Biliary cirrhosis \| 2 HP:0006689 \| Bacterial endocarditis \| 1 HP:0040184 \| Oral hemorrhage \| 1 HP:0011854 \| Hemoperitoneum \| 1 HP:0006517 \| Alveolar proteinosis \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0001369 \| Arthritis \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0012281 \| Chylous ascites \| 1 HP:0006515 \| Interstitial pneumonitis \| 1 HP:0001410 \| Decreased liver function \| 1

Disease ID	218
Disease	microscopic polyangiitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:27) C2697391 \| rheumatoid arthritis C2364133 \| infection C2186530 \| kidney disease C2072946 \| aortic aneurysm C2046121 \| aortic dissection C1963274 \| vasculitis C1801950 \| g syndrome C1739395 \| takotsubo cardiomyopathy C0878544 \| cardiomyopathy C0748159 \| pulmonary involvement C0600260 \| obstructive lung disease C0267953 \| pancreatic necrosis C0155002 \| sudden visual loss C0151295 \| mononeuritis multiplex C0041349 \| tubulointerstitial nephritis C0039445 \| hereditary hemorrhagic telangiectasia C0034069 \| pulmonary fibrosis C0032453 \| relapsing polychondritis C0030167 \| pachymeningitis C0022658 \| renal disease C0019080 \| hemorrhage C0017661 \| iga glomerulonephritis C0017658 \| glomerulonephritis C0017658 \| glomerulonephritides C0007785 \| cerebral infarctions C0006902 \| capillaritis C0002940 \| aneurysms
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0034069 \| pulmonary fibrosis \| 9 C0042384 \| vasculitis \| 4 C0017658 \| glomerulonephritis \| 3 C0748159 \| pulmonary involvement \| 2 C0009450 \| infection \| 2 C0019080 \| hemorrhage \| 2 C0003873 \| rheumatoid arthritis \| 1 C0002940 \| aneurysms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001933	Subcutaneous hemorrhage	MP:0006185	retinal hemorrhage;HP:0008046	Abnormality of the retinal vasculature

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000246	Sinusitis	MP:0011250	abdominal situs ambiguus;HP:0002586	Peritonitis

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C2347126	cyclophosphamide	D003520	50-18-0	microscopic polyangiitis	MESH:D055953	therapeutic	19184066
C2347126	methotrexate	D008727	1959/5/2	microscopic polyangiitis	MESH:D055953	therapeutic	19184066
C2347126	propylthiouracil	D011441	51-52-5	microscopic polyangiitis	MESH:D055953	marker/mechanism	17039123

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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