PedAM

Pediatric Disease Annotations & Medicines


	meningococcal meningitis

Disease ID	88
Disease	meningococcal meningitis
Definition	A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Synonym	epidemic meningitis epidemics meningitis meningitis meningococcal meningitis, meningococcal meningitis, meningococcal [disease/finding] meningitis, meningococcic meningococcal meningitis (disorder) meningococcal meningitis (disorder) [ambiguous] meningococcic meningitis
Orphanet	ORPHANET:33475
DOID	DOID:9929
ICD10	ICD10CM:A39.0
UMLS	C0025294
MeSH	D008585
SNOMED-CT	SNOMEDCT_US_2016_09_01:192644005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:8) C0442874 \| neuropathy \| 1 C0024530 \| malaria \| 1 C0031046 \| pericarditis \| 1 C0025289 \| meningitis \| 1 C0022656 \| renal cortical necrosis \| 1 C0019158 \| hepatitis \| 1 C0014057 \| japanese encephalitis \| 1 C0008354 \| cholera \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) C9 \| 735 \| CTD_human SLC11A1 \| 6556 \| CTD_human CFP \| 5199 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:60) 4074 \| M6PR \| DISEASES 4320 \| MMP11 \| DISEASES 10392 \| NOD1 \| DISEASES 727 \| C5 \| DISEASES 7448 \| VTN \| DISEASES 6688 \| SPI1 \| DISEASES 6556 \| SLC11A1 \| DISEASES 3554 \| IL1R1 \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 23314 \| SATB2 \| DISEASES 735 \| C9 \| DISEASES 729 \| C6 \| DISEASES 492 \| ATP2B3 \| DISEASES 5000 \| ORC4 \| DISEASES 55008 \| HERC6 \| DISEASES 1421 \| CRYGD \| DISEASES 7416 \| VDAC1 \| DISEASES 3394 \| IRF8 \| DISEASES 4794 \| NFKBIE \| DISEASES 4319 \| MMP10 \| DISEASES 23643 \| LY96 \| DISEASES 1173 \| AP2M1 \| DISEASES 11167 \| FSTL1 \| DISEASES 4724 \| NDUFS4 \| DISEASES 64127 \| NOD2 \| DISEASES 5940 \| RBMY1A1 \| DISEASES 154 \| ADRB2 \| DISEASES 6764 \| ST5 \| DISEASES 730 \| C7 \| DISEASES 64332 \| NFKBIZ \| DISEASES 1789 \| DNMT3B \| DISEASES 8398 \| PLA2G6 \| DISEASES 2152 \| F3 \| DISEASES 25870 \| SUMF2 \| DISEASES 7177 \| TPSAB1 \| DISEASES 2224 \| FDPS \| DISEASES 54106 \| TLR9 \| DISEASES 7096 \| TLR1 \| DISEASES 3664 \| IRF6 \| DISEASES 1805 \| DPT \| DISEASES 959 \| CD40LG \| DISEASES 2889 \| RAPGEF1 \| DISEASES 4318 \| MMP9 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 25805 \| BAMBI \| DISEASES 7709 \| ZBTB17 \| DISEASES 10333 \| TLR6 \| DISEASES 6295 \| SAG \| DISEASES 720 \| C4A \| DISEASES 7124 \| TNF \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 4700 \| NDUFA6 \| DISEASES 246734 \| NPCDR1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	88
Disease	meningococcal meningitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:4) HP:0001287 \| Meningitis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0001701 \| Pericarditis \| 1

Disease ID	88
Disease	meningococcal meningitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:22) C2364050 \| hypothermia C1963266 \| uveitis C1963211 \| pericarditis C1963154 \| renal failure C1868998 \| cytotoxic edema C1510428 \| cerebral abscess C1384666 \| hearing impairment C0686709 \| meningococcal conjunctivitis C0155320 \| cortical blindness C0149754 \| periorbital cellulitis C0085650 \| purpura fulminans C0037284 \| skin lesions C0034063 \| pulmonary oedema C0034063 \| pulmonary edema C0032231 \| pleuritis C0026976 \| transverse myelitis C0026837 \| muscle rigidity C0024535 \| falciparum malaria C0017662 \| mesangiocapillary glomerulonephritis C0009450 \| infectious diseases C0008513 \| chorioretinitis C0003864 \| arthritis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0031046 \| pericarditis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743704	20500688	7097	TLR2	umls:C0025294	BeFree	Our data, in combination with a report by others show that the TLR2-P631H allele could be associated with protection to meningococcal meningitis, suggest that by dominantly inhibiting the response of cells important in the immune response this mutant might confer either protection or susceptibility to meningitis or tuberculosis, respectively.	0.003181358	2010	TLR2	4	153704799	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000083	Renal insufficiency	MP:0003335	exocrine pancreatic insufficiency;

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000365	Hearing impairment	MP:0010465	aberrant origin of the right subclavian artery;HP:0001701	Pericarditis

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0025294	ciprofloxacin	D002939	85721-33-1	meningitis, meningococcal	MESH:D008585	therapeutic	7876629
C0025294	rifampin	D012293	13292-46-1	meningitis, meningococcal	MESH:D008585	therapeutic	7876629

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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