PedAM

Pediatric Disease Annotations & Medicines


	meningitis

Disease ID	534
Disease	meningitis
Definition	Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Synonym	meningitides meningitis (disorder) meningitis [disease/finding] meningitis nos meningitis of unspecified cause meningitis of unspecified cause (disorder) meningitis, nos meningitis, unspecified unspecified meningitis unspecified meningitis (disorder)
DOID	DOID:9471
ICD10	ICD10CM:G03.9
UMLS	C0025289
MeSH	D008581
SNOMED-CT	SNOMEDCT_US_2016_09_01:7180009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:214) C0020255 \| hydrocephalus \| 33 C0032285 \| pneumoniae \| 17 C0032285 \| pneumonia \| 15 C0041296 \| tuberculosis \| 11 C0014038 \| encephalitis \| 9 C0018784 \| sensorineural hearing loss \| 8 C0029882 \| otitis media \| 7 C0025303 \| meningococcal disease \| 7 C0151740 \| intracranial hypertension \| 7 C0023860 \| listeriosis \| 5 C0042769 \| virus infection \| 5 C0014118 \| endocarditis \| 5 C0270629 \| epidural abscess \| 5 C0151740 \| raised intracranial pressure \| 5 C0019158 \| hepatitis \| 5 C0024530 \| malaria \| 5 C0004623 \| bacterial infection \| 5 C0442874 \| neuropathy \| 4 C0020538 \| hypertension \| 4 C0271429 \| acute otitis media \| 4 C0026975 \| myelitis \| 4 C0021400 \| influenzae \| 4 C0037198 \| sinus thrombosis \| 4 C0032269 \| pneumococcal infection \| 4 C0009451 \| communicating hydrocephalus \| 4 C0007785 \| cerebral infarction \| 3 C0014236 \| endophthalmitis \| 3 C0029443 \| osteomyelitis \| 3 C0238454 \| cavernous sinus thrombosis \| 3 C0014070 \| encephalomyelitis \| 3 C0549423 \| obstructive hydrocephalus \| 3 C0010414 \| cryptococcosis \| 3 C0042769 \| viral infection \| 3 C0037199 \| sinusitis \| 3 C0456909 \| blindness \| 3 C0040053 \| thrombosis \| 3 C0007785 \| cerebral infarct \| 3 C0038463 \| strongyloidiasis \| 3 C0085437 \| bacterial meningitis \| 3 C0019348 \| herpes simplex \| 3 C0497327 \| dementia \| 3 C0011847 \| diabetes \| 3 C0042384 \| vasculitis \| 3 C0026934 \| mycoplasma \| 3 C0242379 \| lung cancer \| 2 C0019196 \| hepatitis c \| 2 C0151740 \| elevated intracranial pressure \| 2 C0024299 \| lymphoma \| 2 C0023890 \| liver cirrhosis \| 2 C0019360 \| zoster \| 2 C0025309 \| meningoencephalitis \| 2 C0162293 \| papillitis \| 2 C0010346 \| crohn's disease \| 2 C0038220 \| status epilepticus \| 2 C0022893 \| labyrinthitis \| 2 C0030353 \| papilledema \| 2 C0021400 \| influenza \| 2 C0008049 \| chickenpox \| 2 C0085253 \| adult-onset still's disease \| 2 C0035078 \| renal failure \| 2 C0014059 \| acute disseminated encephalomyelitis \| 2 C0151740 \| increased intracranial pressure \| 2 C0519030 \| klebsiella pneumonia \| 2 C0004623 \| bacterial infections \| 2 C0015230 \| rash \| 2 C0014544 \| epilepsy \| 2 C0026780 \| mumps \| 2 C0035204 \| respiratory diseases \| 2 C0011849 \| diabetes mellitus \| 2 C0035204 \| respiratory disease \| 2 C0040558 \| toxoplasmosis \| 2 C0029132 \| optic neuropathy \| 2 C0456909 \| vision loss \| 2 C1527311 \| brain edema \| 2 C0038539 \| subdural empyema \| 2 C0025290 \| aseptic meningitis \| 2 C0025306 \| meningococcemia \| 2 C0037886 \| sphenoid sinusitis \| 2 C0041327 \| pulmonary tb \| 2 C0270612 \| leukoencephalopathy \| 1 C0027813 \| neuritis \| 1 C0019937 \| horner's syndrome \| 1 C0007682 \| cns disease \| 1 C0002766 \| analgesia \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0024796 \| marfan's syndrome \| 1 C0029882 \| middle ear infection \| 1 C0392662 \| angiostrongyliasis \| 1 C0023418 \| leukemia \| 1 C0026764 \| myeloma \| 1 C0025295 \| pneumococcal meningitis \| 1 C0007847 \| cervical cancer \| 1 C0024534 \| cerebral malaria \| 1 C0376545 \| hematological malignancies \| 1 C0042384 \| angiitis \| 1 C0276028 \| haemophilus influenzae meningitis \| 1 C1140680 \| ovarian cancer \| 1 C0015230 \| exanthema \| 1 C0030305 \| pancreatitis \| 1 C0023890 \| cirrhosis \| 1 C0040553 \| toxocara infection \| 1 C0027059 \| myocarditis \| 1 C0035222 \| acute respiratory distress syndrome \| 1 C0014121 \| infective endocarditis \| 1 C0009782 \| connective tissue disorders \| 1 C0043117 \| immune thrombocytopenic purpura \| 1 C0037928 \| myelopathy \| 1 C0026764 \| multiple myeloma \| 1 C0271355 \| sixth nerve palsy \| 1 C0011570 \| depression \| 1 C0003874 \| septic arthritis \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0014068 \| encephalomalacia \| 1 C0679466 \| cognitive deficits \| 1 C0011603 \| dermatitis \| 1 C1565489 \| renal insufficiency \| 1 C0302592 \| uterine cervical cancer \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0023467 \| acute myeloid leukemia \| 1 C1704437 \| respiratory distress syndrome \| 1 C0019163 \| hepatitis b \| 1 C0019360 \| herpes zoster \| 1 C0023524 \| progressive multifocal leucoencephalopathy \| 1 C0001623 \| adrenal insufficiency \| 1 C0025299 \| meningocele \| 1 C0152021 \| congenital heart disease \| 1 C0748616 \| sellar tumor \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0027765 \| neurological disorders \| 1 C0034372 \| quadriplegia \| 1 C0015645 \| fasciitis \| 1 C0014544 \| seizure disorder \| 1 C0276688 \| pulmonary cryptococcosis \| 1 C0003708 \| arachnoiditis \| 1 C0149931 \| migraine \| 1 C0023470 \| myeloid leukemia \| 1 C0026896 \| myasthenia gravis \| 1 C0041321 \| miliary tb \| 1 C0042170 \| harada disease \| 1 C0087086 \| thrombi \| 1 C0011854 \| type 1 diabetes \| 1 C0155320 \| cortical blindness \| 1 C0002871 \| anemia \| 1 C0018799 \| heart disease \| 1 C0042075 \| urological disorders \| 1 C0015464 \| facial palsy \| 1 C0035319 \| acute retinal necrosis \| 1 C0007789 \| cerebral palsy \| 1 C0003175 \| anthrax \| 1 C0023448 \| lymphocytic leukemia \| 1 C0007131 \| non-small cell lung cancer \| 1 C0039144 \| syringomyelia \| 1 C0008354 \| cholera \| 1 C0409974 \| lupus erythematosus \| 1 C0019348 \| herpes simplex virus infection \| 1 C0026946 \| fungal infection \| 1 C0001418 \| adenocarcinoma \| 1 C0014541 \| epiglottitis \| 1 C0025007 \| measles \| 1 C0349006 \| staphylococcus aureus septicemia \| 1 C0153392 \| nasopharyngeal cancer \| 1 C0025229 \| melioidosis \| 1 C0025297 \| viral meningitis \| 1 C0003864 \| arthritis \| 1 C0031046 \| pericarditis \| 1 C0010414 \| cryptococcus neoformans \| 1 C0149925 \| small cell lung cancer \| 1 C0919659 \| oropharyngeal candidiasis \| 1 C0238124 \| necrotizing fasciitis \| 1 C0029134 \| optic neuritis \| 1 C0152013 \| lung adenocarcinoma \| 1 C0031347 \| pharyngeal cancer \| 1 C0026709 \| mps vi \| 1 C0743039 \| progressive dementia \| 1 C0009782 \| connective tissue disorder \| 1 C0013261 \| duane syndrome \| 1 C0002878 \| hemolytic anemia \| 1 C0014060 \| encephalitis c \| 1 C0025362 \| mental retardation \| 1 C0013595 \| eczematous dermatitis \| 1 C0025294 \| meningococcal meningitis \| 1 C0032269 \| pneumococcal infections \| 1 C0078981 \| arachnoid cyst \| 1 C0241910 \| autoimmune hepatitis \| 1 C0008311 \| cholangitis \| 1 C0267917 \| acute cholangitis \| 1 C0019045 \| haemoglobinopathy \| 1 C0013371 \| shigella \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0004943 \| behcet's disease \| 1 C1847523 \| abducens palsy \| 1 C0042373 \| vascular disease \| 1 C0007758 \| cerebellar ataxia \| 1 C0162429 \| malnourished \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0025306 \| meningococcal sepsis \| 1 C0024205 \| lymphadenitis \| 1 C0024115 \| pulmonary disease \| 1 C0343525 \| lemierre's syndrome \| 1 C0086543 \| cataract \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C1140680 \| ovarian ca \| 1 C0302592 \| cervical ca \| 1 C0027947 \| neutropenia \| 1 C0751955 \| brain infarct \| 1 C0008049 \| varicella \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0013182 \| drug hypersensitivity \| 1 C0042170 \| vogt-koyanagi-harada disease \| 1 C0007131 \| nsclc \| 1 C0026769 \| multiple sclerosis \| 1 C0006840 \| candidiasis \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0027765 \| neurological disorder \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) C8B \| 732 \| CTD_human CRP \| 1401 \| CTD_human C8A \| 731 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:485) 100506492 \| DSCAM-AS1 \| DISEASES 6362 \| CCL18 \| DISEASES 920 \| CD4 \| DISEASES 6591 \| SNAI2 \| DISEASES 84245 \| MRI1 \| DISEASES 3385 \| ICAM3 \| DISEASES 634 \| CEACAM1 \| DISEASES 4710 \| NDUFB4 \| DISEASES 27248 \| ERLEC1 \| DISEASES 23505 \| TMEM131 \| DISEASES 9812 \| KIAA0141 \| DISEASES 7066 \| THPO \| DISEASES 54187 \| NANS \| DISEASES 4282 \| MIF \| DISEASES 158 \| ADSL \| DISEASES 5411 \| PNN \| DISEASES 5020 \| OXT \| DISEASES 3929 \| LBP \| DISEASES 10857 \| PGRMC1 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 11151 \| CORO1A \| DISEASES 4210 \| MEFV \| DISEASES 3163 \| HMOX2 \| DISEASES 1512 \| CTSH \| DISEASES 2137 \| EXTL3 \| DISEASES 5327 \| PLAT \| DISEASES 2765 \| GML \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 10392 \| NOD1 \| DISEASES 6369 \| CCL24 \| DISEASES 5054 \| SERPINE1 \| DISEASES 113263 \| GLCCI1 \| DISEASES 727 \| C5 \| DISEASES 733 \| C8G \| DISEASES 7431 \| VIM \| DISEASES 29760 \| BLNK \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 6346 \| CCL1 \| DISEASES 7448 \| VTN \| DISEASES 3558 \| IL2 \| DISEASES 51166 \| AADAT \| DISEASES 3732 \| CD82 \| DISEASES 4048 \| LTA4H \| DISEASES 4940 \| OAS3 \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 2026 \| ENO2 \| DISEASES 55856 \| ACOT13 \| DISEASES 6908 \| TBP \| DISEASES 9450 \| LY86 \| DISEASES 23438 \| HARS2 \| DISEASES 1839 \| HBEGF \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 6556 \| SLC11A1 \| DISEASES 3336 \| HSPE1 \| DISEASES 566 \| AZU1 \| DISEASES 6402 \| SELL \| DISEASES 4317 \| MMP8 \| DISEASES 7276 \| TTR \| DISEASES 22936 \| ELL2 \| DISEASES 64895 \| PAPOLG \| DISEASES 51248 \| PDZD11 \| DISEASES 51747 \| LUC7L3 \| DISEASES 10804 \| GJB6 \| DISEASES 11328 \| FKBP9 \| DISEASES 3623 \| INHA \| DISEASES 140686 \| WFDC3 \| DISEASES 54210 \| TREM1 \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 387332 \| TBPL2 \| DISEASES 53947 \| A4GALT \| DISEASES 6351 \| CCL4 \| DISEASES 417 \| ART1 \| DISEASES 5894 \| RAF1 \| DISEASES 3110 \| MNX1 \| DISEASES 4294 \| MAP3K10 \| DISEASES 2670 \| GFAP \| DISEASES 60678 \| EEFSEC \| DISEASES 1401 \| CRP \| DISEASES 3656 \| IRAK2 \| DISEASES 10752 \| CHL1 \| DISEASES 10468 \| FST \| DISEASES 7024 \| TFCP2 \| DISEASES 3569 \| IL6 \| DISEASES 4836 \| NMT1 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 6386 \| SDCBP \| DISEASES 2230 \| FDX1 \| DISEASES 23314 \| SATB2 \| DISEASES 4069 \| LYZ \| DISEASES 1800 \| DPEP1 \| DISEASES 8099 \| CDK2AP1 \| DISEASES 8120 \| AP3B2 \| DISEASES 4053 \| LTBP2 \| DISEASES 9043 \| SPAG9 \| DISEASES 9172 \| MYOM2 \| DISEASES 4591 \| TRIM37 \| DISEASES 11316 \| COPE \| DISEASES 671 \| BPI \| DISEASES 25939 \| SAMHD1 \| DISEASES 10156 \| RASA4 \| DISEASES 5595 \| MAPK3 \| DISEASES 829 \| CAPZA1 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 735 \| C9 \| DISEASES 729 \| C6 \| DISEASES 492 \| ATP2B3 \| DISEASES 28960 \| DCPS \| DISEASES 3574 \| IL7 \| DISEASES 3299 \| HSF4 \| DISEASES 5000 \| ORC4 \| DISEASES 941 \| CD80 \| DISEASES 55008 \| HERC6 \| DISEASES 1356 \| CP \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 950 \| SCARB2 \| DISEASES 1462 \| VCAN \| DISEASES 7416 \| VDAC1 \| DISEASES 1390 \| CREM \| DISEASES 54504 \| CPVL \| DISEASES 7982 \| ST7 \| DISEASES 5286 \| PIK3C2A \| DISEASES 84920 \| ALG10 \| DISEASES 11081 \| KERA \| DISEASES 23344 \| ESYT1 \| DISEASES 3687 \| ITGAX \| DISEASES 7157 \| TP53 \| DISEASES 3454 \| IFNAR1 \| DISEASES 2212 \| FCGR2A \| DISEASES 10899 \| JTB \| DISEASES 10130 \| PDIA6 \| DISEASES 805 \| CALM2 \| DISEASES 9027 \| NAT8 \| DISEASES 23233 \| EXOC6B \| DISEASES 5868 \| RAB5A \| DISEASES 10667 \| FARS2 \| DISEASES 4841 \| NONO \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 133 \| ADM \| DISEASES 4863 \| NPAT \| DISEASES 3606 \| IL18 \| DISEASES 54842 \| MFSD6 \| DISEASES 7082 \| TJP1 \| DISEASES 55079 \| FEZF2 \| DISEASES 84959 \| UBASH3B \| DISEASES 4900 \| NRGN \| DISEASES 23643 \| LY96 \| DISEASES 1525 \| CXADR \| DISEASES 351 \| APP \| DISEASES 56934 \| CA10 \| DISEASES 10563 \| CXCL13 \| DISEASES 123720 \| WHAMM \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 6285 \| S100B \| DISEASES 2220 \| FCN2 \| DISEASES 1173 \| AP2M1 \| DISEASES 6352 \| CCL5 \| DISEASES 4041 \| LRP5 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 10109 \| ARPC2 \| DISEASES 213 \| ALB \| DISEASES 2921 \| CXCL3 \| DISEASES 5648 \| MASP1 \| DISEASES 10085 \| EDIL3 \| DISEASES 4724 \| NDUFS4 \| DISEASES 9607 \| CARTPT \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 27343 \| POLL \| DISEASES 7184 \| HSP90B1 \| DISEASES 4314 \| MMP3 \| DISEASES 7529 \| YWHAB \| DISEASES 64127 \| NOD2 \| DISEASES 762 \| CA4 \| DISEASES 5617 \| PRL \| DISEASES 6356 \| CCL11 \| DISEASES 2990 \| GUSB \| DISEASES 116984 \| ARAP2 \| DISEASES 3688 \| ITGB1 \| DISEASES 6869 \| TACR1 \| DISEASES 260434 \| PYDC1 \| DISEASES 171558 \| PTCRA \| DISEASES 23491 \| CES3 \| DISEASES 3596 \| IL13 \| DISEASES 5046 \| PCSK6 \| DISEASES 9455 \| HOMER2 \| DISEASES 3627 \| CXCL10 \| DISEASES 81851 \| KRTAP1-1 \| DISEASES 2353 \| FOS \| DISEASES 7532 \| YWHAG \| DISEASES 6699 \| SPRR1B \| DISEASES 4968 \| OGG1 \| DISEASES 285335 \| SLC9C1 \| DISEASES 57124 \| CD248 \| DISEASES 695 \| BTK \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 144245 \| ALG10B \| DISEASES 116512 \| MRGPRD \| DISEASES 2286 \| FKBP2 \| DISEASES 836 \| CASP3 \| DISEASES 5511 \| PPP1R8 \| DISEASES 196883 \| ADCY4 \| DISEASES 246777 \| SPESP1 \| DISEASES 653499 \| LGALS7B \| DISEASES 64689 \| GORASP1 \| DISEASES 4179 \| CD46 \| DISEASES 998 \| CDC42 \| DISEASES 30835 \| CD209 \| DISEASES 6440 \| SFTPC \| DISEASES 1776 \| DNASE1L3 \| DISEASES 79966 \| SCD5 \| DISEASES 5551 \| PRF1 \| DISEASES 3291 \| HSD11B2 \| DISEASES 1775 \| DNASE1L2 \| DISEASES 9377 \| COX5A \| DISEASES 4684 \| NCAM1 \| DISEASES 10730 \| YME1L1 \| DISEASES 26526 \| TSPAN16 \| DISEASES 6764 \| ST5 \| DISEASES 80381 \| CD276 \| DISEASES 8289 \| ARID1A \| DISEASES 6863 \| TAC1 \| DISEASES 23017 \| FAIM2 \| DISEASES 730 \| C7 \| DISEASES 56975 \| FAM20C \| DISEASES 4312 \| MMP1 \| DISEASES 26061 \| HACL1 \| DISEASES 57125 \| PLXDC1 \| DISEASES 2 \| A2M \| DISEASES 55432 \| YOD1 \| DISEASES 24140 \| FTSJ1 \| DISEASES 2318 \| FLNC \| DISEASES 4843 \| NOS2 \| DISEASES 1435 \| CSF1 \| DISEASES 716 \| C1S \| DISEASES 151056 \| PLB1 \| DISEASES 7850 \| IL1R2 \| DISEASES 2242 \| FES \| DISEASES 1538 \| CYLC1 \| DISEASES 25834 \| MGAT4C \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 338440 \| ANO9 \| DISEASES 3916 \| LAMP1 \| DISEASES 8986 \| RPS6KA4 \| DISEASES 170392 \| OIT3 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 139886 \| SPIN4 \| DISEASES 2009 \| EML1 \| DISEASES 245711 \| SPDYA \| DISEASES 9094 \| UNC119 \| DISEASES 114548 \| NLRP3 \| DISEASES 2042 \| EPHA3 \| DISEASES 51477 \| ISYNA1 \| DISEASES 554 \| AVPR2 \| DISEASES 23583 \| SMUG1 \| DISEASES 63826 \| SRR \| DISEASES 3329 \| HSPD1 \| DISEASES 10383 \| TUBB4B \| DISEASES 54681 \| P4HTM \| DISEASES 25870 \| SUMF2 \| DISEASES 1508 \| CTSB \| DISEASES 3146 \| HMGB1 \| DISEASES 7177 \| TPSAB1 \| DISEASES 11276 \| SYNRG \| DISEASES 6818 \| SULT1A3 \| DISEASES 3605 \| IL17A \| DISEASES 4771 \| NF2 \| DISEASES 128859 \| BPIFB6 \| DISEASES 7549 \| ZNF2 \| DISEASES 25813 \| SAMM50 \| DISEASES 6483 \| ST3GAL2 \| DISEASES 3921 \| RPSA \| DISEASES 79971 \| WLS \| DISEASES 2551 \| GABPA \| DISEASES 728 \| C5AR1 \| DISEASES 100506658 \| OCLN \| DISEASES 5265 \| SERPINA1 \| DISEASES 283420 \| CLEC9A \| DISEASES 3240 \| HP \| DISEASES 140885 \| SIRPA \| DISEASES 5284 \| PIGR \| DISEASES 6288 \| SAA1 \| DISEASES 801 \| CALM1 \| DISEASES 83658 \| DYNLRB1 \| DISEASES 135250 \| RAET1E \| DISEASES 5169 \| ENPP3 \| DISEASES 6714 \| SRC \| DISEASES 157680 \| VPS13B \| DISEASES 6364 \| CCL20 \| DISEASES 5294 \| PIK3CG \| DISEASES 493911 \| PHOSPHO2 \| DISEASES 7037 \| TFRC \| DISEASES 5599 \| MAPK8 \| DISEASES 54106 \| TLR9 \| DISEASES 100049587 \| SIGLEC14 \| DISEASES 219972 \| MPEG1 \| DISEASES 9267 \| CYTH1 \| DISEASES 731 \| C8A \| DISEASES 4512 \| MT-CO1 \| DISEASES 115265 \| DDIT4L \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 9851 \| KIAA0753 \| DISEASES 1270 \| CNTF \| DISEASES 6905 \| TBCE \| DISEASES 28514 \| DLL1 \| DISEASES 142 \| PARP1 \| DISEASES 3664 \| IRF6 \| DISEASES 1378 \| CR1 \| DISEASES 6993 \| DYNLT1 \| DISEASES 5788 \| PTPRC \| DISEASES 1805 \| DPT \| DISEASES 2214 \| FCGR3A \| DISEASES 9439 \| MED23 \| DISEASES 9447 \| AIM2 \| DISEASES 10763 \| NES \| DISEASES 6281 \| S100A10 \| DISEASES 1755 \| DMBT1 \| DISEASES 2209 \| FCGR1A \| DISEASES 1081 \| CGA \| DISEASES 3654 \| IRAK1 \| DISEASES 51750 \| RTEL1 \| DISEASES 4534 \| MTM1 \| DISEASES 2633 \| GBP1 \| DISEASES 81894 \| SLC25A28 \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 642489 \| FKBP1C \| DISEASES 10026 \| PIGK \| DISEASES 3725 \| JUN \| DISEASES 732 \| C8B \| DISEASES 202500 \| TCTE1 \| DISEASES 5730 \| PTGDS \| DISEASES 7422 \| VEGFA \| DISEASES 2889 \| RAPGEF1 \| DISEASES 958 \| CD40 \| DISEASES 729238 \| SFTPA2 \| DISEASES 4318 \| MMP9 \| DISEASES 93643 \| TJAP1 \| DISEASES 401262 \| CRIP3 \| DISEASES 5328 \| PLAU \| DISEASES 51148 \| CERCAM \| DISEASES 100 \| ADA \| DISEASES 55315 \| SLC29A3 \| DISEASES 2833 \| CXCR3 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 7580 \| ZNF32 \| DISEASES 2582 \| GALE \| DISEASES 5774 \| PTPN3 \| DISEASES 359710 \| BPIFB3 \| DISEASES 25805 \| BAMBI \| DISEASES 10919 \| EHMT2 \| DISEASES 3376 \| IARS \| DISEASES 199 \| AIF1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 22921 \| MSRB2 \| DISEASES 160897 \| GPR180 \| DISEASES 94027 \| CGB7 \| DISEASES 765 \| CA6 \| DISEASES 5100 \| PCDH8 \| DISEASES 768 \| CA9 \| DISEASES 6354 \| CCL7 \| DISEASES 3963 \| LGALS7 \| DISEASES 1906 \| EDN1 \| DISEASES 79625 \| NDNF \| DISEASES 2683 \| B4GALT1 \| DISEASES 3559 \| IL2RA \| DISEASES 1993 \| ELAVL2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 51284 \| TLR7 \| DISEASES 2874 \| GPS2 \| DISEASES 4267 \| CD99 \| DISEASES 2280 \| FKBP1A \| DISEASES 427 \| ASAH1 \| DISEASES 5555 \| PRH2 \| DISEASES 10333 \| TLR6 \| DISEASES 93978 \| CLEC6A \| DISEASES 4155 \| MBP \| DISEASES 2706 \| GJB2 \| DISEASES 361 \| AQP4 \| DISEASES 9467 \| SH3BP5 \| DISEASES 8812 \| CCNK \| DISEASES 22900 \| CARD8 \| DISEASES 4099 \| MAG \| DISEASES 114609 \| TIRAP \| DISEASES 2719 \| GPC3 \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 6164 \| RPL34 \| DISEASES 5530 \| PPP3CA \| DISEASES 4145 \| MATK \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 2919 \| CXCL1 \| DISEASES 174 \| AFP \| DISEASES 1859 \| DYRK1A \| DISEASES 8091 \| HMGA2 \| DISEASES 7018 \| TF \| DISEASES 1052 \| CEBPD \| DISEASES 6295 \| SAG \| DISEASES 57703 \| CWC22 \| DISEASES 5349 \| FXYD3 \| DISEASES 51135 \| IRAK4 \| DISEASES 1936 \| EEF1D \| DISEASES 653269 \| POTEI \| DISEASES 146713 \| RBFOX3 \| DISEASES 23705 \| CADM1 \| DISEASES 117246 \| FTSJ3 \| DISEASES 720 \| C4A \| DISEASES 653509 \| SFTPA1 \| DISEASES 4908 \| NTF3 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 4615 \| MYD88 \| DISEASES 5817 \| PVR \| DISEASES 4049 \| LTA \| DISEASES 94115 \| CGB8 \| DISEASES 26168 \| SENP3 \| DISEASES 388372 \| CCL4L1 \| DISEASES 9498 \| SLC4A8 \| DISEASES 84148 \| KAT8 \| DISEASES 5578 \| PRKCA \| DISEASES 2668 \| GDNF \| DISEASES 1154 \| CISH \| DISEASES 283337 \| ZNF740 \| DISEASES 834 \| CASP1 \| DISEASES 389549 \| FEZF1 \| DISEASES 4140 \| MARK3 \| DISEASES 3586 \| IL10 \| DISEASES 5554 \| PRH1 \| DISEASES 627 \| BDNF \| DISEASES 51164 \| DCTN4 \| DISEASES 721 \| C4B \| DISEASES 4753 \| NELL2 \| DISEASES 6565 \| SLC15A2 \| DISEASES 4700 \| NDUFA6 \| DISEASES 8801 \| SUCLG2 \| DISEASES 5478 \| PPIA \| DISEASES 56244 \| BTNL2 \| DISEASES 5158 \| PDE6B \| DISEASES 51428 \| DDX41 \| DISEASES 27071 \| DAPP1 \| DISEASES 8649 \| LAMTOR3 \| DISEASES 2920 \| CXCL2 \| DISEASES 2994 \| GYPB \| DISEASES 9788 \| MTSS1 \| DISEASES 6230 \| RPS25 \| DISEASES 4586 \| MUC5AC \| DISEASES 930 \| CD19 \| DISEASES 83695 \| RHNO1 \| DISEASES 3684 \| ITGAM \| DISEASES 83857 \| TMTC1 \| DISEASES 3939 \| LDHA \| DISEASES 8972 \| MGAM \| DISEASES 3851 \| KRT4 \| DISEASES 51303 \| FKBP11 \| DISEASES 567 \| B2M \| DISEASES 8778 \| SIGLEC5 \| DISEASES 820 \| CAMP \| DISEASES 246734 \| NPCDR1 \| DISEASES 102723508 \| KANTR \| DISEASES 100885779 \| LINC-ROR \| DISEASES 79104 \| MEG8 \| DISEASES 654321 \| SNORA75 \| DISEASES 9298 \| SNORD31 \| DISEASES 26769 \| SNORD81 \| DISEASES
Locus	(Waiting for update.)

Disease ID	534
Disease	meningitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:157) HP:0000238 \| Nonsyndromal hydrocephalus \| 30 HP:0002315 \| Headaches \| 22 HP:0001945 \| Fever \| 18 HP:0100806 \| Sepsis \| 15 HP:0002090 \| Pneumonia \| 15 HP:0001297 \| Cerebral vascular events \| 13 HP:0000365 \| Hearing impairment \| 11 HP:0001250 \| Seizures \| 10 HP:0002721 \| Immunodeficiency \| 9 HP:0002383 \| Encephalitis \| 9 HP:0000407 \| sensorineural hearing loss \| 9 HP:0000388 \| Otitis media \| 8 HP:0002516 \| Intracranial pressure elevation \| 6 HP:0030049 \| Brain abscess \| 5 HP:0100584 \| Endocarditis \| 5 HP:0012115 \| Liver inflammation \| 5 HP:0000016 \| Urinary retention \| 4 HP:0002013 \| Emesis \| 4 HP:0000371 \| Acute middle ear infection \| 4 HP:0012486 \| Inflammation of spinal cord \| 4 HP:0000822 \| Hypertension \| 4 HP:0002754 \| Bone infection \| 3 HP:0012531 \| Pain \| 3 HP:0002181 \| Cerebral edema \| 3 HP:0001334 \| Communicating hydrocephalus \| 3 HP:0001259 \| Coma \| 3 HP:0002633 \| Vasculitis \| 3 HP:0002018 \| Nausea \| 3 HP:0000083 \| Renal insufficiency \| 3 HP:0000969 \| Dropsy \| 3 HP:0000618 \| Blindness \| 3 HP:0008619 \| Bilateral sensorineural hearing impairment \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0002716 \| Lymph node hyperplasia \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0012089 \| Arteritis \| 2 HP:0001085 \| Papilledema \| 2 HP:0100280 \| Morbus Crohn \| 2 HP:0002170 \| Intracranial hemorrhage \| 2 HP:0100754 \| Mania \| 2 HP:0100523 \| Hepatic abscess \| 2 HP:0011349 \| Sixth nerve palsy \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0002665 \| Lymphoma \| 2 HP:0100543 \| Cognitive deficits \| 2 HP:0000246 \| Sinus inflammation \| 2 HP:0002401 \| Strokelike episodes \| 2 HP:0000010 \| Frequent urinary tract infections \| 2 HP:0000572 \| Visual loss \| 2 HP:0001880 \| Eosinophilia \| 2 HP:0001138 \| Damaged optic nerve \| 2 HP:0000726 \| Dementia \| 2 HP:0001269 \| Hemiparesis \| 2 HP:0004326 \| Cachexia \| 2 HP:0012229 \| Cerebrospinal fluid pleocytosis \| 2 HP:0001289 \| Confusion \| 2 HP:0002133 \| Status epilepticus \| 1 HP:0002329 \| Drowsiness \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0012683 \| Pineal cyst \| 1 HP:0040197 \| Encephalomalacia \| 1 HP:0001701 \| Pericarditis \| 1 HP:0005224 \| Rectal abscess \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0001548 \| Overgrowth \| 1 HP:0002321 \| Vertigo \| 1 HP:0012541 \| Cephalohaematoma \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0012532 \| Chronic pain \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0001909 \| Leukemia \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0001974 \| Leukocytosis \| 1 HP:0100704 \| Cortical visual impairment \| 1 HP:0100774 \| Hyperostosis \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0002781 \| Upper airway obstruction \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0011986 \| Ectopic bone formation \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0003470 \| Inability to move \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0002277 \| Horner's syndrome \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0100702 \| Arachnoid cyst \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0100246 \| Osteoma \| 1 HP:0030692 \| Brain tumor \| 1 HP:0012219 \| Erythema nodosum \| 1 HP:0002196 \| Myelopathy \| 1 HP:0002435 \| Meningocele \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0012199 \| Cluster headache \| 1 HP:0007293 \| Anterior sacral meningocele \| 1 HP:0100847 \| Pustulosis palmaris et plantaris \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0030358 \| Non-small cell lung carcinoma \| 1 HP:0000127 \| Salt wasting \| 1 HP:0030746 \| Intraventricular hemorrhage \| 1 HP:0010783 \| Erythema \| 1 HP:0012735 \| Coughing \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0000737 \| Irritability \| 1 HP:0030151 \| Cholangitis \| 1 HP:0100017 \| Capsular cataract \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0001369 \| Arthritis \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0002144 \| Occult spinal dysraphism \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0002410 \| Aqueductal stenosis \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0000952 \| Yellow skin \| 1 HP:0005765 \| Sacral meningocele \| 1 HP:0000716 \| Depression \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0001251 \| Ataxia \| 1 HP:0001988 \| hypoglycemia, recurrent \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001903 \| Anemia \| 1 HP:0012819 \| Myocarditis \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0007824 \| Total ophthalmoplegia \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0003396 \| Syringomyelia \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0011450 \| CNS infection \| 1 HP:0012820 \| Bilateral vocal cord paralysis \| 1 HP:0001291 \| Cranial nerve disease \| 1 HP:0002324 \| Hydrancephaly \| 1 HP:0000518 \| Cataract \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0100796 \| Orchitis \| 1 HP:0003401 \| Paresthesia \| 1 HP:0000389 \| Chronic otitis media \| 1 HP:0001875 \| Neutropenia \| 1 HP:0001249 \| Mental retardation \| 1 HP:0012714 \| Severe hearing loss \| 1 HP:0002039 \| Anorexia \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002253 \| Colonic diverticulosis \| 1 HP:0001268 \| Mental deterioration \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0200119 \| Acute liver inflammation \| 1

Disease ID	534
Disease	meningitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:41) C0009450 \| infection \| 56 C0021311 \| infections \| 35 C0020255 \| hydrocephalus \| 30 C0018681 \| headache \| 21 C0032285 \| pneumoniae \| 17 C1384666 \| hearing loss \| 16 C0036690 \| sepsis \| 15 C0032268 \| pneumocephalus \| 9 C0011053 \| deafness \| 8 C0036572 \| seizures \| 6 C0016169 \| fistula \| 5 C0426768 \| o sign \| 5 C0341742 \| acute urinary retention \| 4 C0021400 \| influenzae \| 4 C1260880 \| rhinorrhea \| 4 C0151740 \| intracranial hypertension \| 4 C1839611 \| n syndrome \| 3 C0019348 \| herpes simplex \| 3 C0021308 \| infarction \| 3 C1384666 \| hearing impairment \| 3 C1393529 \| vascular complications \| 2 C0030353 \| papilledema \| 2 C0040558 \| toxoplasmosis \| 2 C0018483 \| haemophilus influenzae \| 2 C0085584 \| encephalopathy \| 2 C1510428 \| cerebral abscess \| 2 C0037886 \| sphenoid sinusitis \| 2 C0014236 \| endophthalmitis \| 2 C0025306 \| meningococcemia \| 2 C0024141 \| systemic lupus erythematosus \| 1 C0003864 \| arthritis \| 1 C0007785 \| cerebral infarction \| 1 C0019270 \| herniation \| 1 C0038525 \| subarachnoid hemorrhage \| 1 C1141920 \| shunt infection \| 1 C0038220 \| status epilepticus \| 1 C0011052 \| prelingual deafness \| 1 C1320474 \| nuchal rigidity \| 1 C0031046 \| pericarditis \| 1 C0025299 \| meningocele \| 1 C0004623 \| bacterial infections \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:12)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1052133	21651918	142	PARP1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	OGG1;CAMK1	3	9757089	C	G
rs1052133	21651918	4968	OGG1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	OGG1;CAMK1	3	9757089	C	G
rs1052133	21651918	328	APEX1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	OGG1;CAMK1	3	9757089	C	G
rs1136410	21651918	142	PARP1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	PARP1	1	226367601	A	G
rs1136410	21651918	328	APEX1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	PARP1	1	226367601	A	G
rs1136410	21651918	4968	OGG1	umls:C0025289	BeFree	In this work, we have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis.	0.000271442	2011	PARP1	1	226367601	A	G
rs1293762	21050126	4940	OAS3	umls:C0025289	BeFree	Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.	0.000271442	2010	OAS2	12	112993031	T	G
rs15895	21050126	4940	OAS3	umls:C0025289	BeFree	Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.	0.000271442	2010	OAS2	12	113010483	A	G
rs1732778	21050126	4940	OAS3	umls:C0025289	BeFree	Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.	0.000271442	2010	NA	12	113019120	G	A
rs2072136	21050126	4940	OAS3	umls:C0025289	BeFree	Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.	0.000271442	2010	OAS3	12	112961114	G	C,A
rs2285932	21050126	4940	OAS3	umls:C0025289	BeFree	Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group.	0.000271442	2010	OAS3	12	112949145	T	C
rs5743704	20500688	7097	TLR2	umls:C0025289	BeFree	Our data, in combination with a report by others show that the TLR2-P631H allele could be associated with protection to meningococcal meningitis, suggest that by dominantly inhibiting the response of cells important in the immune response this mutant might confer either protection or susceptibility to meningitis or tuberculosis, respectively.	0.000542884	2010	TLR2	4	153704799	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:102)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	94511717	rs3789399	G	C	rs3789399	20694013	8.67E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
1	94512893	rs544830	C	T	rs544830	20694013	3.60E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
1	94516985	rs1191231	A	C	rs1191231	20694013	6.89E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
1	94523113	rs497511	G	A	rs497511	20694013	1.76E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
1	94524784	rs550060	A	G	rs550060	20694013	1.84E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
1	165622207	rs2297765	C	T	rs2297765	20694013	6.84E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
1	178661341	rs16853243	C	T	rs16853243	20694013	4.32E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
1	178686331	rs16853302	A	C	rs16853302	20694013	4.39E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
1	194035948	rs634899	T	C	rs634899	20694013	1.80E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
1	196709774	rs1065489	G	T	rs1065489	20694013	4.74E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
1	196710157	rs11582939	C	T	rs11582939	20694013	6.13E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
1	196760417	rs426736	A	G	rs426736	20694013	5.00E-13	NA	1.59	[1.41-1.82]	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
1	209779953	rs880782	G	A	rs880782	20694013	9.11E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
2	125217386	rs2420864	T	C	rs2420864	20694013	2.77E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
2	174999188	rs4972431	C	T	rs4972431	20694013	1.38E-07	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
2	207453310	rs3821170	C	T	rs3821170	20694013	7.01E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
2	215790001	rs10204986	T	G	rs10204986	20694013	8.07E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
3	105135987	rs13070790	C	T	rs13070790	20694013	5.00E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
3	117200934	rs2927279	A	G	rs2927279	20694013	4.44E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
3	191412597	rs779506	G	A	rs779506	20694013	7.01E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
4	23266728	rs10938932	C	T	rs10938932	20694013	6.17E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
4	23274625	rs6835555	G	A	rs6835555	20694013	3.98E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G,A
4	23309835	rs12502492	A	C	rs12502492	20694013	5.00E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
4	23483330	rs740834	T	C	rs740834	20694013	4.82E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
4	31760859	rs11730273	G	T	rs11730273	20694013	6.88E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G,A
4	41713665	rs11728925	C	A	rs11728925	20694013	2.37E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
4	78192318	rs10491463	T	C	rs10491463	20694013	1.49E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
4	149379537	rs6535611	A	G	rs6535611	20694013	9.59E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
5	55878971	rs12697148	G	T	rs12697148	20694013	8.76E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
5	117943259	rs6870913	C	T	rs6870913	20694013	9.20E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
6	7266055	rs2842362	G	T	rs2842362	20694013	4.15E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
6	7600469	rs6597271	A	G	rs6597271	20694013	9.69E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
6	7601436	rs17398289	T	C	rs17398289	20694013	9.04E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
6	40670716	rs9369226	A	G	rs9369226	20694013	9.63E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
6	58340472	rs12209098	A	C	rs12209098	20694013	5.14E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
6	72603664	rs2040055	C	T	rs2040055	20694013	3.34E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
6	105551229	rs13196925	T	G	rs13196925	20694013	2.25E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
6	131673070	rs4897509	A	G	rs4897509	20694013	8.45E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
6	131675201	rs9483254	A	G	rs9483254	20694013	5.87E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
6	137532751	rs9376268	G	A	rs9376268	20694013	4.00E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
7	29428760	rs7797836	C	T	rs7797836	20694013	5.52E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
7	29431552	rs2391757	A	G	rs2391757	20694013	4.41E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
7	127182308	rs6962882	C	T	rs6962882	20694013	6.82E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
7	127795804	rs10447854	T	C	rs10447854	20694013	1.44E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
8	13395662	rs10089628	T	C	rs10089628	20694013	6.87E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
8	39068176	rs7830326	A	G	rs7830326	20694013	2.70E-26	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
8	41623602	rs11780780	G	A	rs11780780	20694013	3.67E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
8	51337745	rs7839067	G	T	rs7839067	20694013	9.52E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
8	105641573	rs2880074	G	A	rs2880074	20694013	9.75E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
8	125561755	rs3829038	G	A	rs3829038	20694013	5.62E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
8	135030615	rs4897668	A	G	rs4897668	20694013	8.30E-26	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
8	142323189	rs7818687	T	C	rs7818687	20694013	4.41E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
8	143681457	rs11167150	A	G	rs11167150	20694013	8.70E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
9	343981	rs4741821	T	C	rs4741821	20694013	7.21E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
9	89419847	rs7048294	C	T	rs7048294	20694013	3.89E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
10	80923862	rs1749824	C	A	rs1749824	20694013	6.50E-13	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
10	85072264	rs10886114	A	G	rs10886114	20694013	9.22E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
10	113094037	rs10749071	A	G	rs10749071	20694013	1.23E-16	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
10	123913330	rs17103138	T	C	rs17103138	20694013	3.44E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
11	40135242	rs11035693	G	A	rs11035693	20694013	4.74E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
11	42649538	rs11604506	C	T	rs11604506	20694013	4.75E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
11	45181682	rs10838427	C	T	rs10838427	20694013	1.46E-10	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
11	49672943	rs10769599	G	A	rs10769599	20694013	4.10E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
11	57040720	rs1892964	C	A	rs1892964	20694013	9.71E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
11	57060562	rs12792781	T	C	rs12792781	20694013	5.30E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
11	86108112	rs10431169	T	C	rs10431169	20694013	3.03E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
11	88676854	rs655683	G	T	rs655683	20694013	2.15E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
11	93921810	rs1792624	G	A	rs1792624	20694013	9.64E-266	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
11	96528019	rs1371352	A	G	rs1371352	20694013	9.63E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
13	47528545	rs2026692	T	C	rs2026692	20694013	3.63E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
13	61618853	rs9570428	C	T	rs9570428	20694013	4.52E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
13	74449179	rs9573320	A	G	rs9573320	20694013	3.93E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
13	74457689	rs9573322	C	A	rs9573322	20694013	8.73E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
13	86551371	rs9547465	C	T	rs9547465	20694013	3.95E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
13	109821211	rs4976846	T	C	rs4976846	20694013	1.72E-17	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
15	33551767	rs17817048	G	T	rs17817048	20694013	3.75E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
15	33564482	rs8035094	C	T	rs8035094	20694013	5.00E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
15	49102037	rs2899423	G	A	rs2899423	20694013	6.25E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
15	54288558	rs2616917	C	T	rs2616917	20694013	4.74E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
15	89996874	rs10162967	C	T	rs10162967	20694013	2.94E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
15	90000871	rs1020145	G	T	rs1020145	20694013	1.83E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
16	4404620	rs10974	C	T	rs10974	20694013	9.53E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
16	19331458	rs1023441	G	A	rs1023441	20694013	5.56E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
16	55844617	rs2244614	G	A	rs2244614	20694013	9.51E-07	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
17	37341235	rs2301775	A	G	rs2301775	20694013	3.08E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G,A
17	64410915	rs4790911	T	C	rs4790911	20694013	8.27E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
18	61281648	rs2168312	G	A	rs2168312	20694013	2.67E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
18	61344012	rs1011947	G	A	rs1011947	20694013	3.41E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
18	61508463	rs1243056	A	G	rs1243056	20694013	9.94E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
18	61509286	rs1243059	A	G	rs1243059	20694013	4.84E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
18	61512366	rs1243062	G	A	rs1243062	20694013	7.08E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
18	71805503	rs4556879	C	T	rs4556879	20694013	9.75E-07	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T,C
18	71811235	rs9952197	G	A	rs9952197	20694013	1.47E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G,A
18	71816278	rs3737512	G	A	rs3737512	20694013	1.11E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
18	71828924	rs17088883	C	T	rs17088883	20694013	5.48E-06	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
19	50419399	rs1299491	A	C	rs1299491	20694013	8.70E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	C
20	42672411	rs6031318	G	A	rs6031318	20694013	7.35E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
20	52501962	rs4809944	A	G	rs4809944	20694013	5.51E-08	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	G
21	19719426	rs2406176	T	G	rs2406176	20694013	8.86E-12	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	T
22	17152611	rs4819849	A	G	rs4819849	20694013	1.47E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	NA
22	17310741	rs175149	A	G	rs175149	20694013	1.60E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A
22	29456699	rs9625679	A	G	rs9625679	20694013	4.61E-05	NA	NA	NA	475 UK Caucasian cases; 4,703 UK controls	UK(4703)	UK Caucasian(475)	ALL(5178)	EUR(5178)	ALL(5178)	Meningococcal disease	HPOID:0001287	Meningitis	DOID:9931	Waterhouse-Friderichsen syndrome	D008585	Meningitis, Meningococcal	EFOID:0004249	meningococcal infection	Adrenal gland hypofunction	NA	Research Support, Non-U.S. Gov't	A

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:19)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0025289	amikacin	D000583	37517-28-5	meningitis	MESH:D008581	therapeutic	6688276
C0025289	azithromycin	D017963	83905-01-5	meningitis	MESH:D008581	marker/mechanism	12043408
C0025289	aztreonam	D001398	78110-38-0	meningitis	MESH:D008581	therapeutic	3909319
C0025289	baclofen	D001418	1134-47-0	meningitis	MESH:D008581	marker/mechanism	8638810
C0025289	bupivacaine	D002045	2180-92-9	meningitis	MESH:D008581	marker/mechanism	10480179
C0025289	cefotaxime	D002439	63527-52-6	meningitis	MESH:D008581	therapeutic	2041948
C0025289	ceftazidime	D002442	78439-06-2	meningitis	MESH:D008581	therapeutic	3578331
C0025289	chloramphenicol	D002701	56-75-7	meningitis	MESH:D008581	therapeutic	2041948
C0025289	ciprofloxacin	D002939	85721-33-1	meningitis	MESH:D008581	therapeutic	3578331
C0025289	erythromycin	D004917	114-07-8	meningitis	MESH:D008581	therapeutic	947847
C0025289	indomethacin	D007213	53-86-1	meningitis	MESH:D008581	marker/mechanism	20197477
C0025289	linezolid	D000069349	-	meningitis	MESH:D008581	therapeutic	18380704
C0025289	methotrexate	D008727	1959/5/2	meningitis	MESH:D008581	marker/mechanism	285924
C0025289	methotrexate	D008727	1959/5/2	meningitis	MESH:D008581	therapeutic	16864827
C0025289	propylthiouracil	D011441	51-52-5	meningitis	MESH:D008581	marker/mechanism	17329921
C0025289	rifampin	D012293	13292-46-1	meningitis	MESH:D008581	therapeutic	18380704
C0025289	sulfadiazine	D013411	68-35-9	meningitis	MESH:D008581	therapeutic	4761062
C0025289	trimethoprim	D014295	738-70-5	meningitis	MESH:D008581	marker/mechanism	2320959
C0025289	vancomycin	D014640	1404-90-6	meningitis	MESH:D008581	therapeutic	18380704

FDA approved drug and dosage information(Total Drugs:8)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D008581	zyvox	linezolid	400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	TABLET;ORAL	Discontinued	None	Yes	No
MESH:D008581	zyvox	linezolid	200MG/100ML (2MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	No
MESH:D008581	zyvox	linezolid	100MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	Yes
MESH:D008581	zyvox	linezolid	400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	TABLET;ORAL	Discontinued	None	Yes	No
MESH:D008581	zyvox	linezolid	200MG/100ML (2MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	No
MESH:D008581	zyvox	linezolid	100MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	Yes
MESH:D008581	cipro	ciprofloxacin	400MG/40ML (10MG/ML)	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D008581	cipro	ciprofloxacin	250MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:8)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D008581	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D008581	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'
MESH:D008581	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'