PedAM

Pediatric Disease Annotations & Medicines


	membranous nephropathy

Disease ID	247
Disease	membranous nephropathy
Definition	A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Synonym	chronic nephritic syndrome, diffuse membranous glomerulonephritis chronic nephritic syndrome, diffuse membranous glomerulonephritis (disorder) extramembranous glomerulopathy glomerulonephritides, membranous glomerulonephritis membranous glomerulonephritis, membranous glomerulonephritis, membranous [disease/finding] glomerulonephropathy, membranous glomerulopathy, extramembranous glomerulopathy, membranous membranous glomerulonephritides membranous glomerulonephritis membranous glomerulonephritis (disorder) membranous glomerulonephritis nos membranous glomerulonephropathy membranous glomerulopathy membranous nephropathy nos mgn mgn - membranous glomerulonephritis nephropathy, membranous
DOID	DOID:10976
UMLS	C0017665
MeSH	D015433
SNOMED-CT	SNOMEDCT_US_2016_09_01:77182004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:52) C0027726 \| nephrotic syndrome \| 35 C0033687 \| proteinuria \| 9 C0017658 \| glomerulonephritis \| 7 C0027697 \| nephritis \| 7 C0027707 \| interstitial nephritis \| 4 C0022658 \| kidney disease \| 3 C0008312 \| primary biliary cirrhosis \| 3 C0022658 \| renal disease \| 3 C0019163 \| hepatitis b \| 3 C0041349 \| tubulointerstitial nephritis \| 3 C0019158 \| hepatitis \| 3 C0008312 \| biliary cirrhosis \| 3 C0042384 \| vasculitis \| 2 C0022661 \| end-stage renal disease \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0033838 \| kimura's disease \| 2 C0023890 \| cirrhosis \| 2 C0022679 \| cystic kidney \| 2 C0026709 \| mucopolysaccharidosis type vi \| 1 C0040156 \| thyrotoxicosis \| 1 C0152025 \| polyneuropathy \| 1 C0398623 \| hypercoagulable state \| 1 C1509147 \| histiocytoma \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0206644 \| fibrous histiocytoma \| 1 C0524988 \| schnitzler syndrome \| 1 C0017662 \| membranoproliferative glomerulonephritis \| 1 C0041234 \| chagas disease \| 1 C0009402 \| colorectal cancer \| 1 C0023418 \| leukemia \| 1 C0032027 \| pityriasis rubra pilaris \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0018378 \| guillain-barre syndrome \| 1 C0008728 \| churg-strauss syndrome \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0041296 \| tuberculosis \| 1 C0023448 \| lymphocytic leukemia \| 1 C0403529 \| goodpasture's disease \| 1 C0023895 \| liver disease \| 1 C0178664 \| glomerulosclerosis \| 1 C0017661 \| iga nephropathy \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0011881 \| diabetic kidney disease \| 1 C0026703 \| mucopolysaccharidosis \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0035078 \| renal failure \| 1 C1565489 \| renal insufficiency \| 1 C0302592 \| cervical ca \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0949691 \| spondyloarthropathy \| 1 C0007113 \| rectal cancer \| 1 C0007847 \| cervical cancer \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) HLA-DRB1 \| 3123 \| CTD_human HLA-DQA1 \| 3117 \| CTD_human APOA1 \| 335 \| CTD_human ALB \| 213 \| CTD_human GAA \| 2548 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 1286 \| COL4A4 \| infer 3117 \| HLA-DQA1 \| infer 22925 \| PLA2R1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:181) 3385 \| ICAM3 \| DISEASES 7038 \| TG \| DISEASES 2217 \| FCGRT \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 3558 \| IL2 \| DISEASES 9450 \| LY86 \| DISEASES 3565 \| IL4 \| DISEASES 2908 \| NR3C1 \| DISEASES 5657 \| PRTN3 \| DISEASES 2023 \| ENO1 \| DISEASES 29094 \| LGALSL \| DISEASES 718 \| C3 \| DISEASES 10047 \| CST8 \| DISEASES 391013 \| PLA2G2C \| DISEASES 968 \| CD68 \| DISEASES 3998 \| LMAN1 \| DISEASES 81 \| ACTN4 \| DISEASES 10343 \| PKDREJ \| DISEASES 3975 \| LHX1 \| DISEASES 182 \| JAG1 \| DISEASES 4608 \| MYBPH \| DISEASES 81494 \| CFHR5 \| DISEASES 2799 \| GNS \| DISEASES 3915 \| LAMC1 \| DISEASES 3569 \| IL6 \| DISEASES 27283 \| TINAG \| DISEASES 3685 \| ITGAV \| DISEASES 4069 \| LYZ \| DISEASES 9097 \| USP14 \| DISEASES 114294 \| LACTB \| DISEASES 3959 \| LGALS3BP \| DISEASES 23523 \| CABIN1 \| DISEASES 9466 \| IL27RA \| DISEASES 4036 \| LRP2 \| DISEASES 4811 \| NID1 \| DISEASES 8916 \| HERC3 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 2028 \| ENPEP \| DISEASES 8395 \| PIP5K1B \| DISEASES 92912 \| UBE2Q2 \| DISEASES 6687 \| SPG7 \| DISEASES 8547 \| FCN3 \| DISEASES 57530 \| CGN \| DISEASES 29956 \| CERS2 \| DISEASES 5972 \| REN \| DISEASES 9027 \| NAT8 \| DISEASES 185 \| AGTR1 \| DISEASES 80854 \| SETD7 \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 5800 \| PTPRO \| DISEASES 7082 \| TJP1 \| DISEASES 22925 \| PLA2R1 \| DISEASES 7345 \| UCHL1 \| DISEASES 231 \| AKR1B1 \| DISEASES 1636 \| ACE \| DISEASES 643 \| CXCR5 \| DISEASES 3046 \| HBE1 \| DISEASES 6352 \| CCL5 \| DISEASES 58191 \| CXCL16 \| DISEASES 213 \| ALB \| DISEASES 57619 \| SHROOM3 \| DISEASES 5267 \| SERPINA4 \| DISEASES 3429 \| IFI27 \| DISEASES 7184 \| HSP90B1 \| DISEASES 915 \| CD3D \| DISEASES 51129 \| ANGPTL4 \| DISEASES 661 \| POLR3D \| DISEASES 4330 \| MN1 \| DISEASES 1602 \| DACH1 \| DISEASES 7275 \| TUB \| DISEASES 7369 \| UMOD \| DISEASES 157570 \| ESCO2 \| DISEASES 54205 \| CYCS \| DISEASES 5340 \| PLG \| DISEASES 118430 \| MUCL1 \| DISEASES 5319 \| PLA2G1B \| DISEASES 64236 \| PDLIM2 \| DISEASES 1191 \| CLU \| DISEASES 8542 \| APOL1 \| DISEASES 9377 \| COX5A \| DISEASES 28959 \| TMEM176B \| DISEASES 7173 \| TPO \| DISEASES 147179 \| WIPF2 \| DISEASES 3321 \| IGSF3 \| DISEASES 64089 \| SNX16 \| DISEASES 2 \| A2M \| DISEASES 3309 \| HSPA5 \| DISEASES 51330 \| TNFRSF12A \| DISEASES 1668 \| DEFA3 \| DISEASES 7490 \| WT1 \| DISEASES 5271 \| SERPINB8 \| DISEASES 8214 \| DGCR6 \| DISEASES 6401 \| SELE \| DISEASES 80128 \| TRIM46 \| DISEASES 8710 \| SERPINB7 \| DISEASES 64412 \| GZF1 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 966 \| CD59 \| DISEASES 7335 \| UBE2V1 \| DISEASES 26578 \| OSTF1 \| DISEASES 7225 \| TRPC6 \| DISEASES 26762 \| HAVCR1 \| DISEASES 55561 \| CDC42BPG \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 23556 \| PIGN \| DISEASES 55243 \| KIRREL \| DISEASES 23607 \| CD2AP \| DISEASES 4311 \| MME \| DISEASES 9181 \| ARHGEF2 \| DISEASES 10724 \| MGEA5 \| DISEASES 5891 \| MOK \| DISEASES 88 \| ACTN2 \| DISEASES 1378 \| CR1 \| DISEASES 5321 \| PLA2G4A \| DISEASES 7827 \| NPHS2 \| DISEASES 6675 \| UAP1 \| DISEASES 1490 \| CTGF \| DISEASES 922 \| CD5L \| DISEASES 4942 \| OAT \| DISEASES 9748 \| SLK \| DISEASES 959 \| CD40LG \| DISEASES 8569 \| MKNK1 \| DISEASES 286204 \| CRB2 \| DISEASES 27293 \| SMPDL3B \| DISEASES 4153 \| MBL2 \| DISEASES 3339 \| HSPG2 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 5320 \| PLA2G2A \| DISEASES 23509 \| POFUT1 \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 8718 \| TNFRSF25 \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 375790 \| AGRN \| DISEASES 3440 \| IFNA2 \| DISEASES 5272 \| SERPINB9 \| DISEASES 348801 \| LNP1 \| DISEASES 22908 \| SACM1L \| DISEASES 284217 \| LAMA1 \| DISEASES 28227 \| PPP2R3B \| DISEASES 51429 \| SNX9 \| DISEASES 162239 \| ZFP1 \| DISEASES 11346 \| SYNPO \| DISEASES 87 \| ACTN1 \| DISEASES 6696 \| SPP1 \| DISEASES 152330 \| CNTN4 \| DISEASES 8091 \| HMGA2 \| DISEASES 2909 \| ARHGAP35 \| DISEASES 7018 \| TF \| DISEASES 154810 \| AMOTL1 \| DISEASES 255743 \| NPNT \| DISEASES 8399 \| PLA2G10 \| DISEASES 25801 \| GCA \| DISEASES 720 \| C4A \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 3609 \| ILF3 \| DISEASES 221981 \| THSD7A \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 7029 \| TFDP2 \| DISEASES 51428 \| DDX41 \| DISEASES 84000 \| TMPRSS13 \| DISEASES 930 \| CD19 \| DISEASES 80790 \| CMIP \| DISEASES 8742 \| TNFSF12 \| DISEASES 4157 \| MC1R \| DISEASES 567 \| B2M \| DISEASES 3949 \| LDLR \| DISEASES
Locus	(Waiting for update.)

Disease ID	247
Disease	membranous nephropathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:35) HP:0000100 \| Nephrosis \| 35 HP:0000093 \| Proteinuria \| 9 HP:0000123 \| Nephritis \| 7 HP:0000099 \| Glomerular nephritis \| 6 HP:0001970 \| Interstitial nephritis \| 4 HP:0001907 \| Thromboembolic disease \| 3 HP:0002613 \| Biliary cirrhosis \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0002633 \| Vasculitis \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0000083 \| Renal insufficiency \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0000127 \| Salt wasting \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 1 HP:0002664 \| Neoplasia \| 1 HP:0012593 \| Nephrotic range proteinuria \| 1 HP:0001289 \| Confusion \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0000096 \| Glomerulosclerosis \| 1 HP:0004319 \| Mineralocorticoid insufficiency \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0012574 \| Mesangial hypercellularity \| 1 HP:0001909 \| Leukemia \| 1 HP:0012315 \| Histiocytoma \| 1 HP:0000793 \| Membranoproliferative glomerulonephritis \| 1 HP:0012597 \| Heavy proteinuria \| 1 HP:0001941 \| acidemia \| 1

Disease ID	247
Disease	membranous nephropathy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:35) C2697391 \| rheumatoid arthritis C2697310 \| sarcoidosis C2677535 \| ane syndrome C1963154 \| renal failure C1962974 \| chylothorax C1962972 \| proteinuria C1561644 \| chronic kidney disease (ckd) C1417247 \| glomerulosclerosis C1318533 \| secondary polycythemia C0949691 \| spondyloarthropathy C0850666 \| helicobacter pylori infection C0566602 \| primary sclerosing cholangitis C0521607 \| peritoneal fibrosis C0403416 \| crescentic glomerulonephritis C0268750 \| necrotizing glomerulonephritis C0265050 \| vena cava thrombosis C0238457 \| renal vein thrombosis C0221013 \| systemic mastocytosis C0206669 \| liver cell adenoma C0162678 \| neurofibromatosis C0162557 \| acute hepatic failure C0149678 \| epstein-barr virus infection C0041327 \| pulmonary tuberculosis C0041296 \| tuberculosis C0040053 \| thrombosis C0032461 \| polycythaemia C0030805 \| bullous pemphigoid C0027831 \| recklinghausen's neurofibromatosis C0027726 \| nephrotic syndrome C0027697 \| nephritis C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0017531 \| angiolymphoid hyperplasia C0015624 \| fanconi's syndrome C0011633 \| dermatomyositis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0027726 \| nephrotic syndrome \| 35 C0033687 \| proteinuria \| 9 C0027697 \| nephritis \| 7 C0022661 \| end-stage renal disease \| 2 C0041296 \| tuberculosis \| 1 C0949691 \| spondyloarthropathy \| 1 C0178664 \| glomerulosclerosis \| 1 C0268750 \| necrotizing glomerulonephritis \| 1 C0035078 \| renal failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs397507444	21500982	4524	MTHFR	umls:C0017665	BeFree	Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.	0.000542884	2011	MTHFR	1	11794407	T	G
rs397507444	21500982	2153	F5	umls:C0017665	BeFree	Cerebral sinovenous thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase A1298C mutation in adult membranous glomerulonephritis.	0.000542884	2011	MTHFR	1	11794407	T	G
rs4664308	21323541	22925	PLA2R1	umls:C0017665	GAD	[An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry. This allele may facilitate an autoimmune response against targets such as variants of PLA2R1. Our findings suggest a basi]	0.006905599	2011	PLA2R1;LOC105373717	2	160060986	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:2)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	160917497	rs4664308	A	G	rs4664308	21323541	9.00E-29	NA	2.28	[1.96-2.64]	556 European ancestry cases; 2,338 European ancestry controls	European(2894)	ALL(2894)	EUR(2894)	ALL(2894)	Nephropathy (idiopathic membranous)	HPOID:0000112	Nephropathy	DOID:10976	membranous glomerulonephritis	D015433	Glomerulonephritis, Membranous	EFOID:0004254	membranous glomerulonephritis	Glomerulonephritis	NA	Research Support, Non-U.S. Gov't	A	PLA2R1
6	32605884	rs2187668	C	T	rs2187668	21323541	8.00E-93	NA	4.32	[3.73-5.01]	556 European ancestry cases; 2,338 European ancestry controls	European(2894)	ALL(2894)	EUR(2894)	ALL(2894)	Nephropathy (idiopathic membranous)	HPOID:0000112	Nephropathy	DOID:10976	membranous glomerulonephritis	D015433	Glomerulonephritis, Membranous	EFOID:0004254	membranous glomerulonephritis	Glomerulonephritis	NA	Research Support, Non-U.S. Gov't	G	HLA-DQA1

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:13)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0017665	chlorambucil	D002699	305-03-3	glomerulonephritis, membranous	MESH:D015433	therapeutic	17211287
C0017665	cyclophosphamide	D003520	50-18-0	glomerulonephritis, membranous	MESH:D015433	therapeutic	16234291
C0017665	diclofenac	D004008	15307-86-5	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	7290298
C0017665	fenoprofen	D005279	31879-05-7	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	3146734
C0017665	fluconazole	D015725	86386-73-4	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	17261435
C0017665	gemcitabine	C056507	103882-84-4	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	10528031
C0017665	nabumetone	C035605	42924-53-8	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	8691554
C0017665	propylthiouracil	D011441	51-52-5	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	17472842
C0017665	sirolimus	D020123	53123-88-9	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	15112032
C0017665	tacrolimus	D016559	109581-93-3	glomerulonephritis, membranous	MESH:D015433	therapeutic	9794552
C0017665	tiopronin	D008625	1953/2/2	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	2250412
C0017665	tolmetin	D014046	26171-23-3	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	8691554
C0017665	vinorelbine	C030852	71486-22-1	glomerulonephritis, membranous	MESH:D015433	marker/mechanism	10528031

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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