PedAM

Pediatric Disease Annotations & Medicines


	membranoproliferative glomerulonephritis

Disease ID	599
Disease	membranoproliferative glomerulonephritis
Definition	Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Synonym	chronic glomerulonephritis, lobular glomerulonephritides, hypocomplementemic glomerulonephritides, membranoproliferative glomerulonephritides, mesangiocapillary glomerulonephritis, hypocomplementemic glomerulonephritis, hypocomplementemic, chronic glomerulonephritis, membranoproliferative glomerulonephritis, membranoproliferative [disease/finding] glomerulonephritis, mesangiocapillary hypocomplementemic glomerulonephritides hypocomplementemic glomerulonephritis lobular glomerulonephritis mcgn mcgn - mesangiocapillary glomerulonephritis membranoproliferative glomerulonephritides membranoproliferative glomerulonephritis (mpgn) membranoproliferative glomerulonephritis nos mesangiocapillary glomerulonephritides mesangiocapillary glomerulonephritis mesangiocapillary glomerulonephritis (disorder) mesangiocapillary glomerulonephritis, nos mpgn mpgn - membranoproliferative glomerulonephritis
DOID	DOID:2920
UMLS	C0017662
MeSH	D015432
SNOMED-CT	SNOMEDCT_US_2016_09_01:80321008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:34) C0010403 \| cryoglobulinemia \| 7 C0027726 \| nephrotic syndrome \| 3 C0019158 \| hepatitis \| 3 C0022658 \| nephropathy \| 2 C0010403 \| cryoglobulinaemia \| 2 C0019196 \| hepatitis c \| 2 C0038463 \| strongyloidiasis \| 2 C0035078 \| renal failure \| 2 C0017658 \| glomerulonephritis \| 2 C1136085 \| monoclonal gammopathy \| 2 C0022658 \| renal disease \| 1 C0022661 \| chronic renal failure \| 1 C0019061 \| hemolytic uremic syndrome \| 1 C0041228 \| african trypanosomiasis \| 1 C0042769 \| virus infection \| 1 C0334634 \| mantle cell lymphoma \| 1 C0020676 \| hypothyroidism \| 1 C0024198 \| lyme disease \| 1 C0022661 \| end-stage renal disease \| 1 C0032463 \| polycythaemia vera \| 1 C0001126 \| renal tubular acidosis \| 1 C0027121 \| myositis \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0041227 \| trypanosomiasis \| 1 C0007102 \| colon cancer \| 1 C1389280 \| basal ganglia calcification \| 1 C1527336 \| sjogren's syndrome \| 1 C0021400 \| influenza \| 1 C0015974 \| periodic fever \| 1 C0011633 \| dermatomyositis \| 1 C0796004 \| kabuki syndrome \| 1 C0019163 \| hepatitis b \| 1 C0032461 \| polycythaemia \| 1 C0021053 \| immune disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) PON1 \| 5444 \| CTD_human ALB \| 213 \| CTD_human C1QA \| 712 \| CTD_human CFH \| 3075 \| CTD_human TSLP \| 85480 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:105) 3385 \| ICAM3 \| DISEASES 4210 \| MEFV \| DISEASES 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 7448 \| VTN \| DISEASES 4598 \| MVK \| DISEASES 5657 \| PRTN3 \| DISEASES 1846 \| DUSP4 \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 968 \| CD68 \| DISEASES 1215 \| CMA1 \| DISEASES 5894 \| RAF1 \| DISEASES 10343 \| PKDREJ \| DISEASES 6341 \| SCO1 \| DISEASES 4608 \| MYBPH \| DISEASES 81494 \| CFHR5 \| DISEASES 5959 \| RDH5 \| DISEASES 2799 \| GNS \| DISEASES 3569 \| IL6 \| DISEASES 3685 \| ITGAV \| DISEASES 4069 \| LYZ \| DISEASES 10162 \| LPCAT3 \| DISEASES 9172 \| MYOM2 \| DISEASES 23523 \| CABIN1 \| DISEASES 55717 \| WDR11 \| DISEASES 3383 \| ICAM1 \| DISEASES 6687 \| SPG7 \| DISEASES 57530 \| CGN \| DISEASES 5972 \| REN \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 710 \| SERPING1 \| DISEASES 9056 \| SLC7A7 \| DISEASES 715 \| C1R \| DISEASES 1636 \| ACE \| DISEASES 6285 \| S100B \| DISEASES 1234 \| CCR5 \| DISEASES 3046 \| HBE1 \| DISEASES 5937 \| RBMS1 \| DISEASES 213 \| ALB \| DISEASES 7098 \| TLR3 \| DISEASES 203286 \| ANKS6 \| DISEASES 717 \| C2 \| DISEASES 661 \| POLR3D \| DISEASES 56945 \| MRPS22 \| DISEASES 4327 \| MMP19 \| DISEASES 4179 \| CD46 \| DISEASES 10294 \| DNAJA2 \| DISEASES 3078 \| CFHR1 \| DISEASES 6014 \| RIT2 \| DISEASES 716 \| C1S \| DISEASES 29940 \| DSE \| DISEASES 85480 \| TSLP \| DISEASES 6575 \| SLC20A2 \| DISEASES 6614 \| SIGLEC1 \| DISEASES 921 \| CD5 \| DISEASES 26762 \| HAVCR1 \| DISEASES 2335 \| FN1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3683 \| ITGAL \| DISEASES 23556 \| PIGN \| DISEASES 2526 \| FUT4 \| DISEASES 10724 \| MGEA5 \| DISEASES 4283 \| CXCL9 \| DISEASES 58 \| ACTA1 \| DISEASES 1378 \| CR1 \| DISEASES 10877 \| CFHR4 \| DISEASES 10878 \| CFHR3 \| DISEASES 3075 \| CFH \| DISEASES 7827 \| NPHS2 \| DISEASES 284486 \| THEM5 \| DISEASES 4942 \| OAT \| DISEASES 7272 \| TTK \| DISEASES 959 \| CD40LG \| DISEASES 11093 \| ADAMTS13 \| DISEASES 2889 \| RAPGEF1 \| DISEASES 286204 \| CRB2 \| DISEASES 4153 \| MBL2 \| DISEASES 7056 \| THBD \| DISEASES 8718 \| TNFRSF25 \| DISEASES 83715 \| ESPN \| DISEASES 4868 \| NPHS1 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 51199 \| NIN \| DISEASES 3426 \| CFI \| DISEASES 3029 \| HAGH \| DISEASES 340990 \| OTOG \| DISEASES 25983 \| NGDN \| DISEASES 255743 \| NPNT \| DISEASES 720 \| C4A \| DISEASES 960 \| CD44 \| DISEASES 3106 \| HLA-B \| DISEASES 2821 \| GPI \| DISEASES 7148 \| TNXB \| DISEASES 5270 \| SERPINE2 \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 4925 \| NUCB2 \| DISEASES 8972 \| MGAM \| DISEASES 51499 \| TRIAP1 \| DISEASES 2585 \| GALK2 \| DISEASES 4782 \| NFIC \| DISEASES 677807 \| SNORA22 \| DISEASES
Locus	(Waiting for update.)

Disease ID	599
Disease	membranoproliferative glomerulonephritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0100778 \| Cryoglobulinemia \| 7 HP:0000100 \| Nephrosis \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0003774 \| End-stage renal failure \| 2 HP:0000112 \| Nephropathy \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0000083 \| Renal insufficiency \| 2 HP:0002135 \| Basal ganglia calcification \| 1 HP:0012597 \| Heavy proteinuria \| 1 HP:0100699 \| Scarring \| 1 HP:0002049 \| Proximal renal tubular acidosis \| 1 HP:0001941 \| acidemia \| 1 HP:0011510 \| Drusen \| 1 HP:0003003 \| Colon cancer \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0001945 \| Fever \| 1 HP:0005575 \| Hemolytic-uremic syndrome \| 1 HP:0000821 \| Underactive thyroid \| 1

Disease ID	599
Disease	membranoproliferative glomerulonephritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:16) C1963154 \| renal failure C1963084 \| colitis C1962972 \| proteinuria C1962966 \| retinopathy C1623038 \| cirrhosis C0268731 \| glomerular diseases C0264383 \| organizing pneumonia C0085679 \| hyperchloremia C0085404 \| crow-fukase syndrome C0039263 \| takayasu's arteritis C0036330 \| schistosoma mansoni infection C0027726 \| nephrotic syndrome C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0022660 \| acute renal failure C0010403 \| cryoglobulinemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0010403 \| cryoglobulinemia \| 7 C0027726 \| nephrotic syndrome \| 3 C0035078 \| renal failure \| 2 C0022661 \| end-stage renal disease \| 1 C0022661 \| chronic renal failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0017662	creatine	D003401	57-00-1	glomerulonephritis, membranoproliferative	MESH:D015432	marker/mechanism	14725210
C0017662	phenytoin	D010672	57-41-0	glomerulonephritis, membranoproliferative	MESH:D015432	marker/mechanism	7099337
C0017662	sirolimus	D020123	53123-88-9	glomerulonephritis, membranoproliferative	MESH:D015432	marker/mechanism	15112032
C0017662	spironolactone	D013148	1952/1/7	glomerulonephritis, membranoproliferative	MESH:D015432	therapeutic	16928621
C0017662	tacrolimus	D016559	109581-93-3	glomerulonephritis, membranoproliferative	MESH:D015432	therapeutic	19406543
C0017662	tretinoin	D014212	302-79-4	glomerulonephritis, membranoproliferative	MESH:D015432	marker/mechanism	17686814
C0017662	valsartan	D000068756	-	glomerulonephritis, membranoproliferative	MESH:D015432	therapeutic	16928621

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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