PedAM

Pediatric Disease Annotations & Medicines


	meconium aspiration syndrome

Disease ID	376
Disease	meconium aspiration syndrome
Definition	A serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date.
Synonym	aspiration meconium aspiration meconium syndrome aspiration of meconium aspiration of meconium (disorder) aspiration of meconium -retired- aspiration syndrome, meconium aspiration, meconium mas mas - meconium aspiration syndrome meconium aspiration meconium aspiration nos meconium aspiration syndrome (disorder) meconium aspiration syndrome (finding) meconium aspiration syndrome (finding) [ambiguous] meconium aspiration syndrome [disease/finding] meconium aspiration syndrome nos meconium aspirations meconium inhalation neonatal aspiration of meconium neonatal aspiration of meconium (disorder) of meconium aspiration syndrome, meconium aspiration
Orphanet	ORPHANET:70588
OMIM	OMIM:174800
DOID	DOID:11049
UMLS	C0025048
MeSH	D008471
SNOMED-CT	SNOMEDCT_US_2016_09_01:278927005;SNOMEDCT_US_2016_09_01:206292002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:7) C0020542 \| pulmonary hypertension \| 2 C1145670 \| respiratory failure \| 2 C0004045 \| birth asphyxia \| 1 C1704437 \| respiratory distress syndrome \| 1 C0011570 \| depression \| 1 C0020538 \| hypertension \| 1 C0035229 \| respiratory insufficiency \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:73) 10911 \| UTS2 \| DISEASES 6583 \| SLC22A4 \| DISEASES 9567 \| GTPBP1 \| DISEASES 5020 \| OXT \| DISEASES 8797 \| TNFRSF10A \| DISEASES 6348 \| CCL3 \| DISEASES 55907 \| CMAS \| DISEASES 9450 \| LY86 \| DISEASES 7291 \| TWIST1 \| DISEASES 35 \| ACADS \| DISEASES 6945 \| MLX \| DISEASES 6351 \| CCL4 \| DISEASES 6538 \| SLC6A11 \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 25939 \| SAMHD1 \| DISEASES 1 \| A1BG \| DISEASES 3553 \| IL1B \| DISEASES 1991 \| ELANE \| DISEASES 3930 \| LBR \| DISEASES 196743 \| PAOX \| DISEASES 7356 \| SCGB1A1 \| DISEASES 23643 \| LY96 \| DISEASES 5739 \| PTGIR \| DISEASES 213 \| ALB \| DISEASES 4724 \| NDUFS4 \| DISEASES 115825 \| WDFY2 \| DISEASES 6356 \| CCL11 \| DISEASES 5354 \| PLP1 \| DISEASES 54498 \| SMOX \| DISEASES 27165 \| GLS2 \| DISEASES 5319 \| PLA2G1B \| DISEASES 835 \| CASP2 \| DISEASES 1909 \| EDNRA \| DISEASES 6440 \| SFTPC \| DISEASES 4843 \| NOS2 \| DISEASES 7273 \| TTN \| DISEASES 3005 \| H1F0 \| DISEASES 9464 \| HAND2 \| DISEASES 5742 \| PTGS1 \| DISEASES 4582 \| MUC1 \| DISEASES 1755 \| DMBT1 \| DISEASES 2316 \| FLNA \| DISEASES 129685 \| TAF8 \| DISEASES 5320 \| PLA2G2A \| DISEASES 3055 \| HCK \| DISEASES 4878 \| NPPA \| DISEASES 1906 \| EDN1 \| DISEASES 551 \| AVP \| DISEASES 2813 \| GP2 \| DISEASES 1010 \| CDH12 \| DISEASES 5799 \| PTPRN2 \| DISEASES 55022 \| PID1 \| DISEASES 347734 \| SLC35B2 \| DISEASES 6439 \| SFTPB \| DISEASES 9560 \| CCL4L2 \| DISEASES 9255 \| AIMP1 \| DISEASES 4295 \| MLN \| DISEASES 8399 \| PLA2G10 \| DISEASES 7124 \| TNF \| DISEASES 5817 \| PVR \| DISEASES 9278 \| ZBTB22 \| DISEASES 388372 \| CCL4L1 \| DISEASES 408 \| ARRB1 \| DISEASES 1028 \| CDKN1C \| DISEASES 3684 \| ITGAM \| DISEASES 55922 \| NKRF \| DISEASES 8972 \| MGAM \| DISEASES 820 \| CAMP \| DISEASES 9300 \| SNORD28 \| DISEASES 9297 \| SNORD29 \| DISEASES 26810 \| SNORD41 \| DISEASES 26806 \| SNORD44 \| DISEASES
Locus	(Waiting for update.)

Disease ID	376
Disease	meconium aspiration syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0002878 \| Respiratory failure \| 2 HP:0002093 \| progressive respiratory failure \| 2 HP:0000716 \| Depression \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0012420 \| Meconium staining of amniotic fluid \| 1 HP:0100806 \| Sepsis \| 1 HP:0012758 \| Neurodevelopmental delay \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0000822 \| Hypertension \| 1

Disease ID	376
Disease	meconium aspiration syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:7) C2362319 \| acute respiratory distress syndrome (ards) C1963220 \| pulmonary hypertension C1145670 \| respiratory failure C1135361 \| persistent pulmonary hypertension C0032285 \| pneumonitis C0032285 \| lung inflammation C0031190 \| persistent pulmonary hypertension of the newborn
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C1145670 \| respiratory failure \| 2 C1135361 \| persistent pulmonary hypertension \| 1 C0020542 \| pulmonary hypertension \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0025048	nitric oxide	D009569	10102-43-9	meconium aspiration syndrome	MESH:D008471	therapeutic	10565465

FDA approved drug and dosage information(Total Drugs:1)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D008471	inomax	nitric oxide	100PPM Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	GAS;INHALATION	Discontinued	None	Yes	No

FDA labeling changes(Total Drugs:1)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D008471	12/21/2010	inomax	nitric oxide	Prevention of bronchopulmonary dysplasia	INOmax is not indicated for prevention of BPD in preterm neonates d 34 weeks gestational age.Efficacy for the prevention of BPD in preterm infants was not established in three ldouble-blind, placebo-controlled clinical trials in a total of 2,149 preterm infants Information on clinical trials, adverse reaction	Labeling	B	-	-	-	INO Therapeutics	2/11/2010	FALSE'

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