PedAM
Pediatric Disease Annotations & Medicines
| measles | ||||
| Disease ID | 1005 |
|---|---|
| Disease | measles |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:28) HP:0001945 | Fever | 10 HP:0002090 | Pneumonia | 5 HP:0001250 | Seizures | 4 HP:0002383 | Encephalitis | 4 HP:0002664 | Neoplasia | 4 HP:0002099 | Asthma | 3 HP:0004905 | Vitamin A deficiency | 2 HP:0000618 | Blindness | 2 HP:0002885 | Medulloblastoma | 2 HP:0001888 | Lymphocytopenia | 2 HP:0200043 | Verrucae | 1 HP:0002014 | Diarrhea | 1 HP:0002878 | Respiratory failure | 1 HP:0000388 | Otitis media | 1 HP:0007957 | Corneal clouding | 1 HP:0001289 | Confusion | 1 HP:0100021 | Cerebral palsy | 1 HP:0001369 | Arthritis | 1 HP:0100796 | Orchitis | 1 HP:0002721 | Immunodeficiency | 1 HP:0002373 | Febrile convulsions | 1 HP:0000362 | Otosclerosis | 1 HP:0001909 | Leukemia | 1 HP:0004395 | Malnutrition | 1 HP:0011947 | Respiratory infection | 1 HP:0012384 | Nasal inflammation | 1 HP:0100653 | Optic neuritis | 1 HP:0030692 | Brain tumor | 1 |
| Disease ID | 1005 |
|---|---|
| Disease | measles |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:16) C0009450 | infection | 37 C0015967 | fever | 10 C0021311 | infections | 10 C0015230 | rash | 9 C0032285 | pneumonia | 5 C0014038 | encephalitis | 4 C0021079 | immunosuppression | 3 C0456909 | blindness | 2 C0221200 | koplik's spots | 2 C0024312 | lymphopenia | 2 C0264490 | acute respiratory failure | 1 C0004626 | bacterial pneumonia | 1 C0029882 | otitis media | 1 C0021079 | immune suppression | 1 C0029134 | optic neuritis | 1 C0011991 | diarrhea | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:47) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs104893941 | 21195346 | 8878 | SQSTM1 | umls:C0025007 | BeFree | Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease. | 0.000271442 | 2011 | SQSTM1 | 5 | 179836445 | C | T |
| rs10776909 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134396900 | T | C |
| rs10776909 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134396900 | T | C |
| rs11102986 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134393657 | A | G |
| rs11102986 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134393657 | A | G |
| rs11103473 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134395783 | T | A |
| rs11103473 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134395783 | T | A |
| rs11103482 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134396014 | T | C |
| rs11103482 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134396014 | T | C |
| rs11265452 | 22086389 | 3586 | IL10 | umls:C0025007 | BeFree | Two polymorphisms (coding rs164288 and intronic rs11265452) in the SLAM gene that were associated with measles antibody levels in our previous study were associated with IFN-γ Elispot (p = 0.04) and IL-10 responses (p = 0.0008), respectively, in this study. | 0.000814326 | 2011 | SLAMF1 | 1 | 160624448 | A | G |
| rs11265452 | 22086389 | 3458 | IFNG | umls:C0025007 | BeFree | Two polymorphisms (coding rs164288 and intronic rs11265452) in the SLAM gene that were associated with measles antibody levels in our previous study were associated with IFN-γ Elispot (p = 0.04) and IL-10 responses (p = 0.0008), respectively, in this study. | 0.007348794 | 2011 | SLAMF1 | 1 | 160624448 | A | G |
| rs12004589 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134398879 | G | T |
| rs12004589 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134398879 | G | T |
| rs164288 | 22086389 | 3586 | IL10 | umls:C0025007 | BeFree | Two polymorphisms (coding rs164288 and intronic rs11265452) in the SLAM gene that were associated with measles antibody levels in our previous study were associated with IFN-γ Elispot (p = 0.04) and IL-10 responses (p = 0.0008), respectively, in this study. | 0.000814326 | 2011 | SLAMF1 | 1 | 160634683 | G | A |
| rs164288 | 22086389 | 3458 | IFNG | umls:C0025007 | BeFree | Two polymorphisms (coding rs164288 and intronic rs11265452) in the SLAM gene that were associated with measles antibody levels in our previous study were associated with IFN-γ Elispot (p = 0.04) and IL-10 responses (p = 0.0008), respectively, in this study. | 0.007348794 | 2011 | SLAMF1 | 1 | 160634683 | G | A |
| rs1799964 | 18715339 | 7124 | TNF | umls:C0025007 | BeFree | Specifically, the minor allele variant of rs1799964 (TNFA -1211 C>T) was associated with primarily seronegative values (median enzyme immunoassay index values < or =0.87; P = 0.002; q = 0.23) in response to measles disease and/or vaccination. | 0.006091273 | 2008 | LTA;TNF;LOC100287329 | 6 | 31574531 | T | C |
| rs1800890 | 21875636 | 3558 | IL2 | umls:C0025007 | BeFree | Similarly, two previously reported promoter IL10 and IL2 polymorphisms (rs1800890 and rs2069762) demonstrated associations with measles-specific cellular immunity in Caucasians (p≤0.034). | 0.001628651 | 2011 | IL10 | 1 | 206776020 | A | T |
| rs1800890 | 21875636 | 3586 | IL10 | umls:C0025007 | BeFree | Similarly, two previously reported promoter IL10 and IL2 polymorphisms (rs1800890 and rs2069762) demonstrated associations with measles-specific cellular immunity in Caucasians (p≤0.034). | 0.000814326 | 2011 | IL10 | 1 | 206776020 | A | T |
| rs2069762 | 21875636 | 3558 | IL2 | umls:C0025007 | BeFree | Similarly, two previously reported promoter IL10 and IL2 polymorphisms (rs1800890 and rs2069762) demonstrated associations with measles-specific cellular immunity in Caucasians (p≤0.034). | 0.001628651 | 2011 | IL2 | 4 | 122456825 | A | C |
| rs2069762 | 21875636 | 3586 | IL10 | umls:C0025007 | BeFree | Similarly, two previously reported promoter IL10 and IL2 polymorphisms (rs1800890 and rs2069762) demonstrated associations with measles-specific cellular immunity in Caucasians (p≤0.034). | 0.000814326 | 2011 | IL2 | 4 | 122456825 | A | C |
| rs2069849 | 18715339 | 3569 | IL6 | umls:C0025007 | BeFree | A heterozygous variant CT for rs2069849 (IL6 +4272C>T; Phe201Phe) was also associated with seronegative values and a lower median level of antibody response to measles disease and/or vaccination (P = 0.004; q = 0.36) or measles vaccination alone (P = 0.008). | 0.003181358 | 2008 | IL6 | 7 | 22731537 | C | T |
| rs2229857 | 21939710 | 103 | ADAR | umls:C0025007 | BeFree | Genotype and haplotype-level associations demonstrated the role of ADAR genetic variants, including a non-synonymous SNP (rs2229857/Arg384Lys; p=0.01), in regulating measles virus-specific IFN-γ Elispot responses in Caucasians (haplotype global p-value=0.017). | 0.001085767 | 2011 | ADAR | 1 | 154601491 | T | C |
| rs2266677 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | NA | NA | NA | NA | NA |
| rs2266677 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | NA | NA | NA | NA | NA |
| rs2284552 | 25139337 | 3588 | IL10RB | umls:C0025007 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.002909916 | 2014 | IL10RB | 21 | 33271777 | G | T |
| rs2284552 | 25139337 | 3593 | IL12B | umls:C0025007 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.000814326 | 2014 | IL10RB | 21 | 33271777 | G | T |
| rs2546893 | 25139337 | 3593 | IL12B | umls:C0025007 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.000814326 | 2014 | IL12B | 5 | 159328952 | G | A |
| rs2546893 | 25139337 | 3588 | IL10RB | umls:C0025007 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.002909916 | 2014 | IL12B | 5 | 159328952 | G | A |
| rs3118571 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134426332 | C | T |
| rs3118571 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134426332 | C | T |
| rs3205166 | 21939710 | 5920 | RARRES3 | umls:C0025007 | BeFree | Genetic variants within the DDX58/RIG-I gene, including a coding polymorphism (rs3205166/Val800Val), were associated as single-SNPs (p≤0.017; although these SNPs did not remain significant after correction for false discovery rate/FDR) and in haplotype-level analysis, with measles-specific antibody variations in Caucasians (haplotype allele p-value=0.021; haplotype global p-value=0.076). | 0.002171535 | 2011 | DDX58;LOC101060445 | 9 | 32459452 | T | G |
| rs3212227 | 21875636 | 3593 | IL12B | umls:C0025007 | BeFree | Our study replicated an important previously found association of a functional IL12B genetic variant rs3212227 with variations in measles-specific humoral immunity (p=0.037). | 0.000814326 | 2011 | IL12B | 5 | 159315942 | T | G |
| rs35780541 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134399894 | C | T |
| rs35780541 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134399894 | C | T |
| rs3804100 | 21424379 | 7099 | TLR4 | umls:C0025007 | BeFree | The major alleles of coding SNPs in the TLR2 (rs3804100) and TLR4 (rs5030710) genes were associated with a dose-related increase (660 vs. 892 mIU/ml, p = 0.002) and a dose-related decrease (2,209 vs. 830 mIU/ml, p = 0.001) in measles-specific antibodies, respectively. | 0.000814326 | 2011 | TLR2 | 4 | 153704257 | T | C |
| rs386561757 | 21939710 | 103 | ADAR | umls:C0025007 | BeFree | Genotype and haplotype-level associations demonstrated the role of ADAR genetic variants, including a non-synonymous SNP (rs2229857/Arg384Lys; p=0.01), in regulating measles virus-specific IFN-γ Elispot responses in Caucasians (haplotype global p-value=0.017). | 0.001085767 | 2011 | NA | NA | NA | NA | NA |
| rs4986790 | 24690400 | 7099 | TLR4 | umls:C0025007 | BeFree | May TLR4 Asp299Gly and IL17 His161Arg polymorphism be associated with progression of primary measles infection to subacute sclerosing panencephalitis? | 0.000814326 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs5030710 | 21424379 | 7099 | TLR4 | umls:C0025007 | BeFree | The major alleles of coding SNPs in the TLR2 (rs3804100) and TLR4 (rs5030710) genes were associated with a dose-related increase (660 vs. 892 mIU/ml, p = 0.002) and a dose-related decrease (2,209 vs. 830 mIU/ml, p = 0.001) in measles-specific antibodies, respectively. | 0.000814326 | 2011 | TLR4 | 9 | 117712443 | T | C |
| rs6537944 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134420982 | T | C |
| rs6537944 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134420982 | T | C |
| rs6550976 | 22082653 | 7124 | TNF | umls:C0025007 | BeFree | The RARB haplotype (rs6800566/rs6550976/rs9834818) was significantly associated with variations in both measles antibody (global, P=0.013) and cytokine secretion levels, such as interleukin (IL)-10 (global, P=0.006), interferon (IFN)-α (global, P=0.008), and tumor necrosis factor-α (global, P=0.039) in the Caucasian subgroup. | 0.006091273 | 2012 | RARB | 3 | 25439187 | C | T |
| rs669260 | 25139337 | 23586 | DDX58 | umls:C0025007 | BeFree | An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). | 0.002442977 | 2014 | DDX58 | 9 | 32503442 | T | C |
| rs6800566 | 22082653 | 7124 | TNF | umls:C0025007 | BeFree | The RARB haplotype (rs6800566/rs6550976/rs9834818) was significantly associated with variations in both measles antibody (global, P=0.013) and cytokine secretion levels, such as interleukin (IL)-10 (global, P=0.006), interferon (IFN)-α (global, P=0.008), and tumor necrosis factor-α (global, P=0.039) in the Caucasian subgroup. | 0.006091273 | 2012 | RARB | 3 | 25439153 | G | A |
| rs6897932 | 21875636 | 3458 | IFNG | umls:C0025007 | BeFree | Multiple IL7R polymorphisms, including a non-synonymous functional SNP (rs6897932/Thr244Ile), were associated with humoral (p≤0.024) and/or cellular (IFNγ Elispot, p≤0.023) measles-specific immune responses in Caucasians, but not African-Americans. | 0.007348794 | 2011 | IL7R | 5 | 35874473 | C | T |
| rs875444 | 22082653 | 6256 | RXRA | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.000271442 | 2012 | RXRA | 9 | 134403458 | G | A |
| rs875444 | 22082653 | 3458 | IFNG | umls:C0025007 | BeFree | A significant association was found between lower measles-specific IFN-γ Enzyme-linked immunosorbent spot responses and haplotypes rs11102986/rs11103473/rs11103482/rs10776909/rs12004589/rs35780541/rs2266677/rs875444 (global, P=0.004) and rs6537944/rs3118571 (global, P<0.001) in the RXRA gene for Caucasians. | 0.007348794 | 2012 | RXRA | 9 | 134403458 | G | A |
| rs9834818 | 22082653 | 7124 | TNF | umls:C0025007 | BeFree | The RARB haplotype (rs6800566/rs6550976/rs9834818) was significantly associated with variations in both measles antibody (global, P=0.013) and cytokine secretion levels, such as interleukin (IL)-10 (global, P=0.006), interferon (IFN)-α (global, P=0.008), and tumor necrosis factor-α (global, P=0.039) in the Caucasian subgroup. | 0.006091273 | 2012 | RARB | 3 | 25439269 | G | C |
GWASdb Annotation(Total Genotypes:0) | |
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GWASdb Snp Trait(Total Genotypes:0) | |
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Mapped by lexical matching(Total Items:0) |
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Mapped by homologous gene(Total Items:0) |
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Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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