PedAM

Pediatric Disease Annotations & Medicines


	mantle cell lymphoma

Disease ID	27
Disease	mantle cell lymphoma
Definition	A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Synonym	[m]malignant lymphoma, lymphocytic, intermediate differentiation, diffuse [m]malignant lymphoma, lymphocytic, intermediate differentiation, diffuse (morphologic abnormality) cell lymphoma mantle centrocytic small-cell lymphoma centrocytic small-cell lymphomas diffuse lymphocytic lymphoma poorly differ diffuse lymphocytic lymphoma, poorly differentiated diffuse lymphocytic lymphoma, poorly-differentiated diffuse pdl lymphoma diffuse poorly-differentiated lymphocytic lymphoma dpdl lymphoma lymphocytic lymphoma diffuse poorly differ lymphocytic lymphoma, diffuse, poorly differentiated lymphocytic lymphoma, diffuse, poorly-differentiated lymphoma lymphocytic diffuse intermediate differ lymphoma lymphocytic diffuse poorly differ lymphoma, centrocytic small cell lymphoma, centrocytic small-cell lymphoma, lymphocytic, diffuse, intermediate differentiated lymphoma, lymphocytic, diffuse, poorly-differentiated lymphoma, mantle cell lymphoma, mantle-cell lymphoma, mantle-cell [disease/finding] lymphoma, mantle-zone lymphoma, small-cell, centrocytic lymphomas, centrocytic small-cell lymphomas, mantle-cell lymphomas, mantle-zone malignant lymphoma, centrocytic [obs] malignant lymphoma, lymphocytic, intermediate differentiation, diffuse malignant lymphoma, lymphocytic, intermediate differentiation, diffuse [obs] malignant lymphoma, lymphocytic, intermediate differentiation, nodular [obs] malignant lymphoma, lymphocytic, poorly differentiated, diffuse malignant lymphoma, lymphocytic, poorly differentiated, diffuse [obs] mantle cell lymphoma (disorder) mantle cell lymphoma (morphologic abnormality) mantle cell lymphomas mantle zone lymphoma mantle zone lymphoma [obs] mantle-cell lymphoma mantle-cell lymphomas mantle-zone lymphoma mantle-zone lymphomas mcl small-cell lymphoma, centrocytic small-cell lymphomas, centrocytic
Orphanet	ORPHANET:52416
OMIM	OMIM:609964
DOID	DOID:0050746
UMLS	C0334634
MeSH	D020522
SNOMED-CT	SNOMEDCT_US_2016_09_01:443487006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:42) C0024299 \| lymphoma \| 4 C0023418 \| leukemia \| 4 C0040034 \| thrombocytopenia \| 2 C0002871 \| anaemia \| 2 C0023448 \| lymphocytic leukemia \| 2 C0002878 \| haemolytic anaemia \| 2 C0024301 \| follicular lymphoma \| 2 C0024299 \| lymphomas \| 2 C0002880 \| autoimmune haemolytic anaemia \| 2 C0017662 \| membranoproliferative glomerulonephritis \| 1 C0242379 \| lung malignancy \| 1 C1527336 \| sjogren's syndrome \| 1 C0178664 \| glomerulosclerosis \| 1 C0027051 \| myocardial infarct \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0026764 \| myeloma \| 1 C0003615 \| appendicitis \| 1 C1261473 \| sarcoma \| 1 C0023470 \| myeloid leukemia \| 1 C0007102 \| colon cancer \| 1 C0392548 \| cauda equina syndrome \| 1 C0004135 \| ataxia telangiectasia \| 1 C0034902 \| pure red cell aplasia \| 1 C0027662 \| multiple endocrine neoplasia \| 1 C0282548 \| leukostasis \| 1 C0035078 \| renal failure \| 1 C0025268 \| multiple endocrine neoplasia type 2 \| 1 C1522378 \| large granular lymphocytic leukemia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0004134 \| ataxia \| 1 C0026764 \| multiple myeloma \| 1 C0027051 \| myocardial infarction \| 1 C0022660 \| acute renal failure \| 1 C0023492 \| t cell leukemia \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0006413 \| burkitt lymphoma \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0281963 \| red cell aplasia \| 1 C0017658 \| glomerulonephritis \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0018213 \| graves' disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) AK1 \| 203 \| CTD_human CCND1 \| 595 \| CTD_human;ORPHANET WNT3 \| 7473 \| CTD_human CTNNB1 \| 1499 \| CTD_human MTOR \| 2475 \| CTD_human ARHGAP29 \| 9411 \| CTD_human GSK3B \| 2932 \| CTD_human EIF4EBP1 \| 1978 \| CTD_human IGH \| 3492 \| ORPHANET ATM \| 472 \| CLINVAR;ORPHANET PIK3CD \| 5293 \| CTD_human EIF4E \| 1977 \| CTD_human CLEC4D \| 338339 \| OMIM WNT10A \| 80326 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:301) 10301 \| DLEU1 \| DISEASES 8847 \| DLEU2 \| DISEASES 972 \| CD74 \| DISEASES 933 \| CD22 \| DISEASES 100271849 \| MEF2B \| DISEASES 602 \| BCL3 \| DISEASES 6634 \| SNRPD3 \| DISEASES 113791 \| PIK3IP1 \| DISEASES 638 \| BIK \| DISEASES 5427 \| POLE2 \| DISEASES 4792 \| NFKBIA \| DISEASES 55734 \| ZFP64 \| DISEASES 64743 \| WDR13 \| DISEASES 1445 \| CSK \| DISEASES 55824 \| PAG1 \| DISEASES 10535 \| RNASEH2A \| DISEASES 973 \| CD79A \| DISEASES 1440 \| CSF3 \| DISEASES 7473 \| WNT3 \| DISEASES 6198 \| RPS6KB1 \| DISEASES 230 \| ALDOC \| DISEASES 952 \| CD38 \| DISEASES 595 \| CCND1 \| DISEASES 10635 \| RAD51AP1 \| DISEASES 1027 \| CDKN1B \| DISEASES 57379 \| AICDA \| DISEASES 26271 \| FBXO5 \| DISEASES 55770 \| EXOC2 \| DISEASES 3565 \| IL4 \| DISEASES 6500 \| SKP1 \| DISEASES 51185 \| CRBN \| DISEASES 604 \| BCL6 \| DISEASES 7128 \| TNFAIP3 \| DISEASES 3007 \| HIST1H1D \| DISEASES 1026 \| CDKN1A \| DISEASES 6659 \| SOX4 \| DISEASES 8744 \| TNFSF9 \| DISEASES 970 \| CD70 \| DISEASES 1236 \| CCR7 \| DISEASES 482 \| ATP1B2 \| DISEASES 599 \| BCL2L2 \| DISEASES 1603 \| DAD1 \| DISEASES 3110 \| MNX1 \| DISEASES 6382 \| SDC1 \| DISEASES 1022 \| CDK7 \| DISEASES 4853 \| NOTCH2 \| DISEASES 902 \| CCNH \| DISEASES 29923 \| HILPDA \| DISEASES 60468 \| BACH2 \| DISEASES 1019 \| CDK4 \| DISEASES 55213 \| RCBTB1 \| DISEASES 10643 \| IGF2BP3 \| DISEASES 3569 \| IL6 \| DISEASES 9099 \| USP2 \| DISEASES 9411 \| ARHGAP29 \| DISEASES 894 \| CCND2 \| DISEASES 23495 \| TNFRSF13B \| DISEASES 3839 \| KPNA3 \| DISEASES 10426 \| TUBGCP3 \| DISEASES 79817 \| MOB3B \| DISEASES 945 \| CD33 \| DISEASES 1031 \| CDKN2C \| DISEASES 9620 \| CELSR1 \| DISEASES 5595 \| MAPK3 \| DISEASES 3682 \| ITGAE \| DISEASES 330 \| BIRC3 \| DISEASES 943 \| TNFRSF8 \| DISEASES 5290 \| PIK3CA \| DISEASES 2208 \| FCER2 \| DISEASES 941 \| CD80 \| DISEASES 54940 \| OCIAD1 \| DISEASES 59067 \| IL21 \| DISEASES 22794 \| CASC3 \| DISEASES 6774 \| STAT3 \| DISEASES 5276 \| SERPINI2 \| DISEASES 7535 \| ZAP70 \| DISEASES 51176 \| LEF1 \| DISEASES 1021 \| CDK6 \| DISEASES 8379 \| MAD1L1 \| DISEASES 939 \| CD27 \| DISEASES 1017 \| CDK2 \| DISEASES 6601 \| SMARCC2 \| DISEASES 3687 \| ITGAX \| DISEASES 1039 \| CDR2 \| DISEASES 7157 \| TP53 \| DISEASES 207 \| AKT1 \| DISEASES 8915 \| BCL10 \| DISEASES 5686 \| PSMA5 \| DISEASES 2212 \| FCGR2A \| DISEASES 83417 \| FCRL4 \| DISEASES 4794 \| NFKBIE \| DISEASES 7462 \| LAT2 \| DISEASES 26260 \| FBXO25 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 1030 \| CDKN2B \| DISEASES 4851 \| NOTCH1 \| DISEASES 472 \| ATM \| DISEASES 932 \| MS4A3 \| DISEASES 204219 \| CERS3 \| DISEASES 23460 \| ABCA6 \| DISEASES 10563 \| CXCL13 \| DISEASES 571 \| BACH1 \| DISEASES 11189 \| CELF3 \| DISEASES 115650 \| TNFRSF13C \| DISEASES 89858 \| SIGLEC12 \| DISEASES 6294 \| SAFB \| DISEASES 643 \| CXCR5 \| DISEASES 308 \| ANXA5 \| DISEASES 9607 \| CARTPT \| DISEASES 22974 \| TPX2 \| DISEASES 84790 \| TUBA1C \| DISEASES 332 \| BIRC5 \| DISEASES 598 \| BCL2L1 \| DISEASES 129025 \| ZNF280A \| DISEASES 3688 \| ITGB1 \| DISEASES 6726 \| SRP9 \| DISEASES 1901 \| S1PR1 \| DISEASES 25998 \| IBTK \| DISEASES 253782 \| CERS6 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 54205 \| CYCS \| DISEASES 695 \| BTK \| DISEASES 947 \| CD34 \| DISEASES 10125 \| RASGRP1 \| DISEASES 9743 \| ARHGAP32 \| DISEASES 27115 \| PDE7B \| DISEASES 8463 \| TEAD2 \| DISEASES 836 \| CASP3 \| DISEASES 1163 \| CKS1B \| DISEASES 5519 \| PPP2R1B \| DISEASES 10007 \| GNPDA1 \| DISEASES 924 \| CD7 \| DISEASES 8837 \| CFLAR \| DISEASES 81037 \| CLPTM1L \| DISEASES 2629 \| GBA \| DISEASES 3234 \| HOXD8 \| DISEASES 23512 \| SUZ12 \| DISEASES 4684 \| NCAM1 \| DISEASES 10419 \| PRMT5 \| DISEASES 10892 \| MALT1 \| DISEASES 2146 \| EZH2 \| DISEASES 6664 \| SOX11 \| DISEASES 951 \| CD37 \| DISEASES 5366 \| PMAIP1 \| DISEASES 8738 \| CRADD \| DISEASES 1850 \| DUSP8 \| DISEASES 596 \| BCL2 \| DISEASES 283869 \| NPW \| DISEASES 842 \| CASP9 \| DISEASES 79680 \| C22orf29 \| DISEASES 23180 \| RFTN1 \| DISEASES 3840 \| KPNA4 \| DISEASES 140890 \| SREK1 \| DISEASES 3320 \| HSP90AA1 \| DISEASES 10376 \| TUBA1B \| DISEASES 6622 \| SNCA \| DISEASES 23583 \| SMUG1 \| DISEASES 51338 \| MS4A4A \| DISEASES 53335 \| BCL11A \| DISEASES 2309 \| FOXO3 \| DISEASES 79469 \| DLEU2L \| DISEASES 966 \| CD59 \| DISEASES 1978 \| EIF4EBP1 \| DISEASES 5810 \| RAD1 \| DISEASES 921 \| CD5 \| DISEASES 10181 \| RBM5 \| DISEASES 400673 \| VMAC \| DISEASES 545 \| ATR \| DISEASES 5549 \| PRELP \| DISEASES 53827 \| FXYD5 \| DISEASES 1499 \| CTNNB1 \| DISEASES 900 \| CCNG1 \| DISEASES 5359 \| PLSCR1 \| DISEASES 2331 \| FMOD \| DISEASES 6666 \| SOX12 \| DISEASES 331 \| XIAP \| DISEASES 8764 \| TNFRSF14 \| DISEASES 355 \| FAS \| DISEASES 5905 \| RANGAP1 \| DISEASES 23035 \| PHLPP2 \| DISEASES 219844 \| HYLS1 \| DISEASES 3683 \| ITGAL \| DISEASES 126308 \| MOB3A \| DISEASES 1084 \| CEACAM3 \| DISEASES 3177 \| SLC29A2 \| DISEASES 5079 \| PAX5 \| DISEASES 841 \| CASP8 \| DISEASES 2213 \| FCGR2B \| DISEASES 2526 \| FUT4 \| DISEASES 5336 \| PLCG2 \| DISEASES 6693 \| SPN \| DISEASES 5599 \| MAPK8 \| DISEASES 4311 \| MME \| DISEASES 2475 \| MTOR \| DISEASES 2882 \| GPX7 \| DISEASES 83416 \| FCRL5 \| DISEASES 57213 \| SPRYD7 \| DISEASES 8556 \| CDC14A \| DISEASES 6665 \| SOX15 \| DISEASES 8476 \| CDC42BPA \| DISEASES 142 \| PARP1 \| DISEASES 1063 \| CENPF \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 26254 \| OPTC \| DISEASES 5788 \| PTPRC \| DISEASES 84824 \| FCRLA \| DISEASES 4332 \| MNDA \| DISEASES 115350 \| FCRL1 \| DISEASES 6016 \| RIT1 \| DISEASES 4082 \| MARCKS \| DISEASES 4288 \| MKI67 \| DISEASES 388697 \| HRNR \| DISEASES 4170 \| MCL1 \| DISEASES 639 \| PRDM1 \| DISEASES 914 \| CD2 \| DISEASES 1268 \| CNR1 \| DISEASES 1847 \| DUSP5 \| DISEASES 959 \| CD40LG \| DISEASES 5567 \| PRKACB \| DISEASES 541466 \| CT45A1 \| DISEASES 4919 \| ROR1 \| DISEASES 1791 \| DNTT \| DISEASES 2030 \| SLC29A1 \| DISEASES 6491 \| STIL \| DISEASES 5728 \| PTEN \| DISEASES 6838 \| SURF6 \| DISEASES 958 \| CD40 \| DISEASES 896 \| CCND3 \| DISEASES 1979 \| EIF4EBP2 \| DISEASES 1025 \| CDK9 \| DISEASES 1104 \| RCC1 \| DISEASES 1043 \| CD52 \| DISEASES 3014 \| H2AFX \| DISEASES 128864 \| C20orf144 \| DISEASES 6850 \| SYK \| DISEASES 3621 \| ING1 \| DISEASES 10673 \| TNFSF13B \| DISEASES 11040 \| PIM2 \| DISEASES 648 \| BMI1 \| DISEASES 2262 \| GPC5 \| DISEASES 10529 \| NEBL \| DISEASES 5293 \| PIK3CD \| DISEASES 5101 \| PCDH9 \| DISEASES 4609 \| MYC \| DISEASES 574028 \| CLLU1 \| DISEASES 3662 \| IRF4 \| DISEASES 11200 \| CHEK2 \| DISEASES 26524 \| LATS2 \| DISEASES 6736 \| SRY \| DISEASES 6419 \| SETMAR \| DISEASES 238 \| ALK \| DISEASES 8812 \| CCNK \| DISEASES 340152 \| ZC3H12D \| DISEASES 6003 \| RGS13 \| DISEASES 152137 \| CCDC50 \| DISEASES 11113 \| CIT \| DISEASES 974 \| CD79B \| DISEASES 10018 \| BCL2L11 \| DISEASES 347734 \| SLC35B2 \| DISEASES 6387 \| CXCL12 \| DISEASES 84433 \| CARD11 \| DISEASES 3676 \| ITGA4 \| DISEASES 23532 \| PRAME \| DISEASES 55614 \| KIF16B \| DISEASES 5970 \| RELA \| DISEASES 7514 \| XPO1 \| DISEASES 8115 \| TCL1A \| DISEASES 25983 \| NGDN \| DISEASES 122706 \| PSMB11 \| DISEASES 644150 \| WIPF3 \| DISEASES 7852 \| CXCR4 \| DISEASES 1111 \| CHEK1 \| DISEASES 1029 \| CDKN2A \| DISEASES 23705 \| CADM1 \| DISEASES 83700 \| JAM3 \| DISEASES 7155 \| TOP2B \| DISEASES 960 \| CD44 \| DISEASES 5795 \| PTPRJ \| DISEASES 4615 \| MYD88 \| DISEASES 26267 \| FBXO10 \| DISEASES 9351 \| SLC9A3R2 \| DISEASES 4050 \| LTB \| DISEASES 23158 \| TBC1D9 \| DISEASES 7153 \| TOP2A \| DISEASES 3586 \| IL10 \| DISEASES 4193 \| MDM2 \| DISEASES 4345 \| CD200 \| DISEASES 6091 \| ROBO1 \| DISEASES 7029 \| TFDP2 \| DISEASES 1977 \| EIF4E \| DISEASES 4067 \| LYN \| DISEASES 51366 \| UBR5 \| DISEASES 100423062 \| IGLL5 \| DISEASES 930 \| CD19 \| DISEASES 567 \| B2M \| DISEASES 1506 \| CTRL \| DISEASES 9212 \| AURKB \| DISEASES 407975 \| MIR17HG \| DISEASES 101927034 \| ROR1-AS1 \| DISEASES 102659353 \| THRIL \| DISEASES
Locus	Symbol \| Locus(Total Locus:3) CCND1 \| 11q13.3 IGH \| 14q32.33 ATM \| 11q22.3

Disease ID	27
Disease	mantle cell lymphoma
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:9) HP:0001945 \| Fever HP:0001824 \| Weight loss HP:0011024 \| Abnormality of the gastrointestinal tract HP:0001744 \| Splenomegaly HP:0012378 \| Fatigue HP:0005561 \| Abnormality of bone marrow cell morphology HP:0002039 \| Anorexia HP:0012191 \| B-cell lymphoma HP:0002716 \| Lymphadenopathy
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:33) HP:0002665 \| Lymphoma \| 4 HP:0002664 \| Neoplasia \| 4 HP:0001909 \| Leukemia \| 4 HP:0001890 \| Autoimmune hemolytic anemia \| 2 HP:0001903 \| Anemia \| 2 HP:0001873 \| Low platelet count \| 2 HP:0001878 \| Haemolytic anaemia \| 2 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001744 \| Splenomegaly \| 1 HP:0003003 \| Colon cancer \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0030731 \| Carcinoma \| 1 HP:0030080 \| Burkitt lymphoma \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0012223 \| Ruptured spleen \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0000793 \| Membranoproliferative glomerulonephritis \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0100806 \| Sepsis \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0012410 \| Pure red cell aplasia \| 1 HP:0100827 \| Lymphocytosis \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0000096 \| Glomerulosclerosis \| 1 HP:0100242 \| Sarcoma \| 1 HP:0001251 \| Ataxia \| 1 HP:0012579 \| Minimal change glomerulonephritis \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0100568 \| Endocrine neoplasia \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001541 \| Ascites \| 1

Disease ID	27
Disease	mantle cell lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:16) C2364133 \| infection C0334638 \| multiple lymphomatous polyposis C0334108 \| polyposis C0235618 \| proliferative glomerulonephritis C0154254 \| polyclonal hypergammaglobulinemia C0149937 \| acute tubulo-interstitial nephritis C0043117 \| idiopathic thrombocytopenic purpura (itp) C0043117 \| idiopathic thrombocytopenic purpura C0037285 \| skin manifestation C0037284 \| skin lesions C0030805 \| bullous pemphigoid C0024205 \| lymphadenitis C0022660 \| acute renal failure C0020625 \| hyponatremia C0015300 \| proptosis C0002880 \| autoimmune haemolytic anaemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0334638 \| multiple lymphomatous polyposis \| 3 C0002880 \| autoimmune haemolytic anaemia \| 2 C0037285 \| skin manifestation \| 2 C0334108 \| polyposis \| 2 C0022660 \| acute renal failure \| 1 C0235618 \| proliferative glomerulonephritis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:7)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs113488022	25511147	673	BRAF	umls:C0334634	BeFree	The performance of the BRAF V600E-specific VE1 antibody was compared with that of allele-specific polymerase chain reaction (PCR) in 22 formalin-fixed, paraffin-embedded (FFPE) specimens with HCL involvement, along with nine splenic marginal zone lymphomas (SMZLs), 10 follicular lymphomas (FLs), 10 mantle cell lymphomas (MCLs), and 10 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLLs).	0.000271442	2015	BRAF	7	140753336	A	T,G,C
rs11547328	22592113	1019	CDK4	umls:C0334634	BeFree	Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3'RR/p53+/- mice.	0.003810118	2012	CDK4;MARCH9	12	57751648	G	A
rs121434221	NA	472	ATM	umls:C0334634	CLINVAR	NA	0.246243163	NA	ATM	11	108329199	A	G
rs121434222	NA	472	ATM	umls:C0334634	CLINVAR	NA	0.246243163	NA	ATM	11	108287687	C	T
rs1800629	20087644	7124	TNF	umls:C0334634	BeFree	TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87).	0.000271442	2010	TNF	6	31575254	G	A
rs1800890	20087644	3586	IL10	umls:C0334634	BeFree	IL10 rs1800890 was associated with risk of diffuse large B-cell lymphoma (OR 1.41, CI 1.08-1.85 for minor allele homozygosity) and mantle cell lymphoma (OR 1.77, CI 1.04-3.00).	0.000542884	2010	IL10	1	206776020	A	T
rs796051857	NA	472	ATM	umls:C0334634	CLINVAR	NA	0.246243163	NA	ATM	11	108329184	-	GAA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001824	Weight loss	MP:0001263	weight loss;

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002716	Lymphadenopathy	MP:0002420	abnormal adaptive immunity;HP:0004377	Hematological neoplasm

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0334634	amifostine	D004999	20537-88-6	lymphoma, mantle-cell	MESH:D020522	therapeutic	11335791
C0334634	arsenic trioxide	C006632	1327-53-3	lymphoma, mantle-cell	MESH:D020522	therapeutic	23949314
C0334634	bendamustine hydrochloride	D000069461	-	lymphoma, mantle-cell	MESH:D020522	therapeutic	18980985
C0334634	bortezomib	D000069286	-	lymphoma, mantle-cell	MESH:D020522	therapeutic	16298074
C0334634	mitoxantrone	D008942	65271-80-9	lymphoma, mantle-cell	MESH:D020522	therapeutic	17228004
C0334634	paclitaxel	D017239	-	lymphoma, mantle-cell	MESH:D020522	therapeutic	7884419
C0334634	temsirolimus	C401859	-	lymphoma, mantle-cell	MESH:D020522	therapeutic	20828385

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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