PedAM

Pediatric Disease Annotations & Medicines


	malignant hypertension

Disease ID	1282
Disease	malignant hypertension
Definition	A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
Synonym	accelerated hypertension hypertension malignant hypertension, accelerated hypertension, malignant hypertension, malignant [disease/finding] malignant hypertension (disorder)
DOID	DOID:10824
UMLS	C0020540
MeSH	D006974
SNOMED-CT	SNOMEDCT_US_2016_09_01:70272006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:26) C0155765 \| microangiopathy \| 4 C0035078 \| renal failure \| 3 C0020538 \| hypertension \| 2 C0085580 \| essential hypertension \| 2 C0152132 \| hypertensive retinopathy \| 2 C0027697 \| nephritis \| 2 C0021933 \| intussusception \| 1 C0011991 \| diarrhea \| 1 C0016052 \| fibromuscular dysplasia \| 1 C0022661 \| chronic kidney disease \| 1 C0018802 \| congestive heart failure \| 1 C0024143 \| lupus nephritis \| 1 C0022658 \| kidney disease \| 1 C0151620 \| hypertensive encephalopathy \| 1 C0022658 \| renal disease \| 1 C0030421 \| paraganglioma \| 1 C0022661 \| end stage renal disease \| 1 C0027051 \| myocardial infarction \| 1 C0022658 \| nephropathy \| 1 C1565489 \| renal insufficiency \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0017661 \| iga nephropathy \| 1 C0022660 \| acute renal failure \| 1 C0027051 \| myocardial infarct \| 1 C1384514 \| primary aldosteronism \| 1 C0020540 \| accelerated hypertension \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) AGT \| 183 \| CTD_human CYP17A1 \| 1586 \| CTD_human REN \| 5972 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:60) 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 173 \| AFM \| DISEASES 10268 \| RAMP3 \| DISEASES 6939 \| TCF15 \| DISEASES 3346 \| HTN1 \| DISEASES 10266 \| RAMP2 \| DISEASES 7450 \| VWF \| DISEASES 25939 \| SAMHD1 \| DISEASES 22858 \| ICK \| DISEASES 5338 \| PLD2 \| DISEASES 5443 \| POMC \| DISEASES 3827 \| KNG1 \| DISEASES 5972 \| REN \| DISEASES 185 \| AGTR1 \| DISEASES 133 \| ADM \| DISEASES 1636 \| ACE \| DISEASES 213 \| ALB \| DISEASES 375611 \| SLC26A5 \| DISEASES 4179 \| CD46 \| DISEASES 1909 \| EDNRA \| DISEASES 8542 \| APOL1 \| DISEASES 25898 \| RCHY1 \| DISEASES 1585 \| CYP11B2 \| DISEASES 9622 \| KLK4 \| DISEASES 153571 \| C5orf38 \| DISEASES 1908 \| EDN3 \| DISEASES 126364 \| LRRC25 \| DISEASES 4306 \| NR3C2 \| DISEASES 23054 \| NCOA6 \| DISEASES 183 \| AGT \| DISEASES 3075 \| CFH \| DISEASES 7827 \| NPHS2 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 1907 \| EDN2 \| DISEASES 55937 \| APOM \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 11074 \| TRIM31 \| DISEASES 3105 \| HLA-A \| DISEASES 1910 \| EDNRB \| DISEASES 10159 \| ATP6AP2 \| DISEASES 2189 \| FANCG \| DISEASES 4868 \| NPHS1 \| DISEASES 1906 \| EDN1 \| DISEASES 7222 \| TRPC3 \| DISEASES 1543 \| CYP1A1 \| DISEASES 551 \| AVP \| DISEASES 6557 \| SLC12A1 \| DISEASES 415 \| ARSE \| DISEASES 51429 \| SNX9 \| DISEASES 10203 \| CALCRL \| DISEASES 11346 \| SYNPO \| DISEASES 3426 \| CFI \| DISEASES 25974 \| MMACHC \| DISEASES 3267 \| AGFG1 \| DISEASES 3550 \| IK \| DISEASES 279 \| AMY2A \| DISEASES 6171 \| RPL41 \| DISEASES 3347 \| HTN3 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1282
Disease	malignant hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0000083 \| Renal insufficiency \| 3 HP:0000822 \| Hypertension \| 2 HP:0000123 \| Nephritis \| 2 HP:0001919 \| Acute renal failure \| 2 HP:0001095 \| Hypertensive retinopathy \| 2 HP:0003774 \| End-stage renal failure \| 1 HP:0002576 \| Intussusception \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002105 \| Hemoptysis \| 1 HP:0002668 \| Paragangliomas \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0200114 \| Metabolic alkalosis \| 1 HP:0002900 \| Hypokalemia \| 1 HP:0001250 \| Seizures \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0002014 \| Diarrhea \| 1 HP:0002573 \| Bloody diarrhea \| 1 HP:0100735 \| Hypertensive crisis \| 1 HP:0000969 \| Dropsy \| 1 HP:0001920 \| Renal artery stenosis \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0005162 \| Left ventricular impairment \| 1 HP:0003470 \| Inability to move \| 1 HP:0001948 \| Alkalosis \| 1

Disease ID	1282
Disease	malignant hypertension
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C2717961 \| thrombotic microangiopathy \| 4 C0035078 \| renal failure \| 3 C0152132 \| hypertensive retinopathy \| 2 C0027697 \| nephritis \| 2 C0035067 \| renal artery stenosis \| 1 C0022660 \| acute renal failure \| 1 C0017661 \| iga nephropathy \| 1 C0022658 \| renal disease \| 1 C0341697 \| renal impairment \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020540	amitriptyline	D000639	50-48-6	hypertension, malignant	MESH:D006974	marker/mechanism	7123337
C0020540	atenolol	D001262	29122-68-7	hypertension, malignant	MESH:D006974	therapeutic	2493837
C0020540	caffeine	D002110	1958/8/2	hypertension, malignant	MESH:D006974	marker/mechanism	3020089
C0020540	chlorthalidone	D002752	77-36-1	hypertension, malignant	MESH:D006974	therapeutic	2493837
C0020540	enalapril	D004656	75847-73-3	hypertension, malignant	MESH:D006974	therapeutic	2493837
C0020540	minoxidil	D008914	38304-91-5	hypertension, malignant	MESH:D006974	therapeutic	21786
C0020540	norepinephrine	D009638	51-41-2	hypertension, malignant	MESH:D006974	marker/mechanism	6373596
C0020540	propranolol	D011433	525-66-6	hypertension, malignant	MESH:D006974	therapeutic	6112544
C0020540	spironolactone	D013148	1952/1/7	hypertension, malignant	MESH:D006974	therapeutic	8723367
C0020540	valsartan	D000068756	-	hypertension, malignant	MESH:D006974	therapeutic	11560862

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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