PedAM
Pediatric Disease Annotations & Medicines
| malignant glioma | ||||
| Disease ID | 1185 |
|---|---|
| Disease | malignant glioma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:11) HP:0002664 | Neoplasia | 26 HP:0100843 | Glioblastoma | 3 HP:0001888 | Lymphocytopenia | 2 HP:0012174 | Glioblastoma multiforme | 2 HP:0001945 | Fever | 1 HP:0001907 | Thromboembolic disease | 1 HP:0002181 | Cerebral edema | 1 HP:0002667 | Wilms tumor | 1 HP:0009733 | Glioma | 1 HP:0002315 | Headaches | 1 HP:0001873 | Low platelet count | 1 |
| Disease ID | 1185 |
|---|---|
| Disease | malignant glioma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:10) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:3) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:9) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs121913500 | 23619925 | 3417 | IDH1 | umls:C0555198 | BeFree | c-Met/nestin/IDH1-R132H expression phenotypes recapitulate the molecular subgroups of malignant glioma. | 0.004614512 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 23934175 | 7157 | TP53 | umls:C0555198 | BeFree | cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. | 0.01601507 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 23619925 | 6664 | SOX11 | umls:C0555198 | BeFree | We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival. | 0.000542884 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 23934175 | 3417 | IDH1 | umls:C0555198 | BeFree | cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. | 0.004614512 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 23619925 | 10763 | NES | umls:C0555198 | BeFree | We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival. | 0.001085767 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 23619925 | 6774 | STAT3 | umls:C0555198 | BeFree | We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival. | 0.000814326 | 2013 | IDH1 | 2 | 208248388 | C | T |
| rs121913500 | 24929863 | 3417 | IDH1 | umls:C0555198 | BeFree | Isocitrate dehydrogenase 1 gene (IDH1) R132H mutation status was also recently identified as a prognostic factor for malignant gliomas. | 0.004614512 | 2014 | IDH1 | 2 | 208248388 | C | T |
| rs55819519 | 23934175 | 3417 | IDH1 | umls:C0555198 | BeFree | cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. | 0.004614512 | 2013 | TP53 | 17 | 7673751 | C | T |
| rs55819519 | 23934175 | 7157 | TP53 | umls:C0555198 | BeFree | cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. | 0.01601507 | 2013 | TP53 | 17 | 7673751 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |