PedAM

Pediatric Disease Annotations & Medicines


	malignant fibroxanthoma

Disease ID	1508
Disease	malignant fibroxanthoma
Definition	A soft tissue sarcoma that usually occurs in the limbs, most commonly the legs, and may also occur in the abdomen.
Synonym	[m]fibroxanthosarcoma [m]fibroxanthosarcoma (disorder) [m]fibroxanthosarcoma (morphologic abnormality) fibrohistiocytic tumor, malignant fibrohistiocytic tumors, malignant fibrous histiocytoma malignant fibrous histiocytoma, malignant fibrous histiocytoma, malignant (morphologic abnormality) fibrous histiocytomas, malignant fibroxanthoma, malignant fibroxanthosarcoma histiocytoma, fibrous, malignant histiocytoma, malignant fibrous histiocytoma, malignant fibrous [disease/finding] histiocytomas, malignant fibrous malignant fibrohistiocytic tumor malignant fibrohistiocytic tumors malignant fibrous cytoma malignant fibrous histiocytoma malignant fibrous histiocytoma (disorder) malignant fibrous histiocytoma of soft tissue and bone malignant fibrous histiocytoma of the soft tissue and bone malignant fibrous histiocytomas mfh storiform-pleomorphic fibrous histiocytoma storiform-pleomorphic malignant fibrous histiocytoma storiform-pleomorphic mfh tumor, malignant fibrohistiocytic tumors, malignant fibrohistiocytic unclassified pleomorphic sarcoma unclassified pleomorphic sarcoma (formerly malignant fibrous histiocytoma) unclassified pleomorphic sarcoma (formerly mfh) undifferentiated high grade pleomorphic sarcoma undifferentiated pleomorphic sarcoma undifferentiated pleomorphic soft tissue sarcoma ups
Orphanet	ORPHANET:2023
DOID	DOID:1907
UMLS	C0334463
MeSH	D051677
SNOMED-CT	SNOMEDCT_US_2016_09_01:443439001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:20) C1261473 \| sarcoma \| 7 C0023827 \| liposarcoma \| 1 C0007847 \| cervical cancer \| 1 C0238198 \| gastrointestinal stromal tumor \| 1 C0008479 \| chondrosarcoma \| 1 C1334699 \| mesenchymal neoplasm \| 1 C0018213 \| graves disease \| 1 C1509147 \| histiocytoma \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0205945 \| spindle cell sarcoma \| 1 C0023448 \| lymphocytic leukemia \| 1 C0040100 \| thymoma \| 1 C0153676 \| lung metastases \| 1 C0023418 \| leukemia \| 1 C0302592 \| cervical ca \| 1 C0007137 \| squamous cell carcinoma \| 1 C0018801 \| heart failure \| 1 C0879615 \| stromal tumor \| 1 C0153676 \| lung metastasis \| 1 C0206644 \| fibrous histiocytoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:153) 4706 \| NDUFAB1 \| DISEASES 972 \| CD74 \| DISEASES 7216 \| TRO \| DISEASES 7049 \| TGFBR3 \| DISEASES 282808 \| RAB40AL \| DISEASES 54 \| ACP5 \| DISEASES 4324 \| MMP15 \| DISEASES 1048 \| CEACAM5 \| DISEASES 2662 \| GDF10 \| DISEASES 1440 \| CSF3 \| DISEASES 8402 \| SLC25A11 \| DISEASES 1277 \| COL1A1 \| DISEASES 4254 \| KITLG \| DISEASES 11272 \| PRR4 \| DISEASES 11103 \| KRR1 \| DISEASES 2026 \| ENO2 \| DISEASES 10804 \| GJB6 \| DISEASES 4656 \| MYOG \| DISEASES 11017 \| SNRNP27 \| DISEASES 9787 \| DLGAP5 \| DISEASES 5300 \| PIN1 \| DISEASES 3315 \| HSPB1 \| DISEASES 4654 \| MYOD1 \| DISEASES 968 \| CD68 \| DISEASES 3852 \| KRT5 \| DISEASES 5589 \| PRKCSH \| DISEASES 2521 \| FUS \| DISEASES 22856 \| CHSY1 \| DISEASES 3845 \| KRAS \| DISEASES 1019 \| CDK4 \| DISEASES 6302 \| TSPAN31 \| DISEASES 3569 \| IL6 \| DISEASES 4069 \| LYZ \| DISEASES 466 \| ATF1 \| DISEASES 6855 \| SYP \| DISEASES 943 \| TNFRSF8 \| DISEASES 119 \| ADD2 \| DISEASES 84162 \| KIAA1109 \| DISEASES 2162 \| F13A1 \| DISEASES 1462 \| VCAN \| DISEASES 29999 \| FSCN3 \| DISEASES 7157 \| TP53 \| DISEASES 57410 \| SCYL1 \| DISEASES 6769 \| STAC \| DISEASES 1956 \| EGFR \| DISEASES 9258 \| MFHAS1 \| DISEASES 4613 \| MYCN \| DISEASES 654 \| BMP6 \| DISEASES 84779 \| NAA11 \| DISEASES 3815 \| KIT \| DISEASES 23516 \| SLC39A14 \| DISEASES 9965 \| FGF19 \| DISEASES 25976 \| TIPARP \| DISEASES 9833 \| MELK \| DISEASES 7486 \| WRN \| DISEASES 9317 \| PTER \| DISEASES 55027 \| HEATR3 \| DISEASES 290 \| ANPEP \| DISEASES 8988 \| HSPB3 \| DISEASES 54360 \| CYTL1 \| DISEASES 26287 \| ANKRD2 \| DISEASES 794 \| CALB2 \| DISEASES 57124 \| CD248 \| DISEASES 4323 \| MMP14 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 9092 \| SART1 \| DISEASES 7094 \| TLN1 \| DISEASES 55884 \| WSB2 \| DISEASES 55342 \| STRBP \| DISEASES 3039 \| HBA1 \| DISEASES 23362 \| PSD3 \| DISEASES 5499 \| PPP1CA \| DISEASES 2303 \| FOXC2 \| DISEASES 3052 \| HCCS \| DISEASES 633 \| BGN \| DISEASES 57121 \| LPAR5 \| DISEASES 64764 \| CREB3L2 \| DISEASES 3855 \| KRT7 \| DISEASES 5155 \| PDGFB \| DISEASES 682 \| BSG \| DISEASES 5501 \| PPP1CC \| DISEASES 23583 \| SMUG1 \| DISEASES 473 \| RERE \| DISEASES 7430 \| EZR \| DISEASES 23193 \| GANAB \| DISEASES 55893 \| ZNF395 \| DISEASES 347 \| APOD \| DISEASES 1739 \| DLG1 \| DISEASES 23386 \| NUDCD3 \| DISEASES 5265 \| SERPINA1 \| DISEASES 9961 \| MVP \| DISEASES 23224 \| SYNE2 \| DISEASES 4763 \| NF1 \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 1999 \| ELF3 \| DISEASES 4151 \| MB \| DISEASES 2157 \| F8 \| DISEASES 25942 \| SIN3A \| DISEASES 4311 \| MME \| DISEASES 800 \| CALD1 \| DISEASES 10724 \| MGEA5 \| DISEASES 9853 \| RUSC2 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 25802 \| LMOD1 \| DISEASES 5788 \| PTPRC \| DISEASES 632 \| BGLAP \| DISEASES 6277 \| S100A6 \| DISEASES 6280 \| S100A9 \| DISEASES 10360 \| NPM3 \| DISEASES 5236 \| PGM1 \| DISEASES 5728 \| PTEN \| DISEASES 10103 \| TSPAN1 \| DISEASES 26301 \| GBGT1 \| DISEASES 4303 \| FOXO4 \| DISEASES 1896 \| EDA \| DISEASES 727837 \| SSX2B \| DISEASES 6756 \| SSX1 \| DISEASES 80036 \| TRPM3 \| DISEASES 4609 \| MYC \| DISEASES 650 \| BMP2 \| DISEASES 57118 \| CAMK1D \| DISEASES 4507 \| MTAP \| DISEASES 6456 \| SH3GL2 \| DISEASES 22902 \| RUFY3 \| DISEASES 4267 \| CD99 \| DISEASES 2315 \| MLANA \| DISEASES 192668 \| CYS1 \| DISEASES 6624 \| FSCN1 \| DISEASES 79705 \| LRRK1 \| DISEASES 238 \| ALK \| DISEASES 12 \| SERPINA3 \| DISEASES 5803 \| PTPRZ1 \| DISEASES 389136 \| VGLL3 \| DISEASES 6222 \| RPS18 \| DISEASES 1029 \| CDKN2A \| DISEASES 8823 \| FGF16 \| DISEASES 6878 \| TAF6 \| DISEASES 2130 \| EWSR1 \| DISEASES 10046 \| MAMLD1 \| DISEASES 9053 \| MAP7 \| DISEASES 51071 \| DERA \| DISEASES 4193 \| MDM2 \| DISEASES 5515 \| PPP2CA \| DISEASES 221223 \| CES5A \| DISEASES 90993 \| CREB3L1 \| DISEASES 4857 \| NOVA1 \| DISEASES 3316 \| HSPB2 \| DISEASES 85316 \| BAGE5 \| DISEASES 104564225 \| MHRT \| DISEASES 26810 \| SNORD41 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1508
Disease	malignant fibroxanthoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0100242 \| Sarcoma \| 7 HP:0002664 \| Neoplasia \| 4 HP:0001289 \| Confusion \| 2 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0030731 \| Carcinoma \| 1 HP:0100647 \| Morbus Basedow \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0100522 \| Thymoma \| 1 HP:0001909 \| Leukemia \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0012315 \| Histiocytoma \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0012034 \| Liposarcoma \| 1 HP:0006765 \| Chondrosarcoma \| 1 HP:0100723 \| Gastrointestinal stroma tumor \| 1

Disease ID	1508
Disease	malignant fibroxanthoma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1346044	18271933	7486	WRN	umls:C0334463	BeFree	An exploratory subgroup analysis without multiple comparison adjustment suggested that the WRN-Cys1367Arg SNP is associated with soft tissue sarcomas, sarcomas with reciprocal chromosomal translocations and malignant fibrous histiocytoma.	0.002995792	2008	WRN;LOC105379359	8	31167138	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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