PedAM
Pediatric Disease Annotations & Medicines
| lymphoproliferative disorders | ||||
| Disease ID | 1028 |
|---|---|
| Disease | lymphoproliferative disorders |
| Definition | Disorders characterized by proliferation of lymphoid tissue, general or unspecified. |
| Synonym | diseases lymphoproliferative disorder, lymphoproliferative disorders lymphoproliferative disorders, lymphoproliferative duncan syndrome duncan's syndrome duncans syndrome lymphoproliferative dis lymphoproliferative disease lymphoproliferative disease (morphologic abnormality) lymphoproliferative disease, no icd-o subtype lymphoproliferative disease, no icd-o subtype (morphologic abnormality) lymphoproliferative disease, no international classification of diseases for oncology subtype lymphoproliferative disease, no international classification of diseases for oncology subtype (morphologic abnormality) lymphoproliferative disease, nos lymphoproliferative disorder lymphoproliferative disorder (disorder) lymphoproliferative disorder (morphologic abnormality) lymphoproliferative disorder nos lymphoproliferative disorders [disease/finding] |
| DOID | |
| UMLS | C0024314 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:59) C0019158 | hepatitis | 7 C0042769 | virus infection | 5 C0021390 | inflammatory bowel disease | 4 C0019196 | hepatitis c | 4 C0023418 | leukemia | 4 C0003873 | rheumatoid arthritis | 4 C0021831 | bowel disease | 3 C0024299 | lymphoma | 3 C0024299 | lymphomas | 3 C0036220 | kaposi sarcoma | 2 C0019829 | hodgkin's lymphoma | 2 C0162855 | mucinosis | 2 C0002871 | anemia | 2 C1527336 | sjogren's syndrome | 2 C0003864 | arthritis | 2 C0024305 | non-hodgkin's lymphoma | 2 C0020538 | hypertension | 2 C1261473 | sarcoma | 2 C0002173 | follicular mucinosis | 2 C0023470 | myeloid leukemia | 2 C0021053 | immune dysfunction | 2 C0026948 | mycosis fungoides | 1 C0007570 | celiac disease | 1 C0398623 | thrombophilia | 1 C0079731 | b-cell non-hodgkin's lymphoma | 1 C0023448 | lymphocytic leukemia | 1 C0019163 | hepatitis b | 1 C0010346 | crohn disease | 1 C0002880 | autoimmune hemolytic anemia | 1 C0023465 | acute monocytic leukemia | 1 C0020541 | portal hypertension | 1 C0079773 | primary cutaneous t-cell lymphoma | 1 C0032285 | pneumonia | 1 C0023473 | chronic myeloid leukemia | 1 C0023434 | chronic lymphocytic leukemia | 1 C0021053 | immune disease | 1 C0026764 | myeloma | 1 C0018202 | granulomatous vasculitis | 1 C0002874 | erythroid aplasia | 1 C0042721 | viral hepatitis | 1 C0242379 | lung cancer | 1 C0017658 | glomerulonephritis | 1 C0598894 | monocytic leukemia | 1 C0345967 | malignant mesothelioma | 1 C0010403 | cryoglobulinemia | 1 C0042384 | vasculitis | 1 C0026946 | mycosis | 1 C0002878 | hemolytic anemia | 1 C0023467 | acute myeloid leukemia | 1 C0032305 | pneumocystis | 1 C0024141 | systemic lupus erythematosus | 1 C0235270 | keratopathy | 1 C1136085 | monoclonal gammopathy | 1 C0409974 | lupus erythematosus | 1 C0030489 | paraproteinemia | 1 C0026896 | myasthenia gravis | 1 C0019618 | histiocytosis | 1 C1619734 | pulmonary arterial hypertension | 1 C0079774 | peripheral t-cell lymphoma | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:3) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:21) 5243 | ABCB1 | infer 578 | BAK1 | infer 2147 | F2 | infer 2153 | F5 | infer 2623 | GATA1 | infer 2811 | GP1BA | infer 3105 | HLA-A | infer 3106 | HLA-B | infer 3586 | IL10 | infer 3587 | IL10RA | infer 3552 | IL1A | infer 3554 | IL1R1 | infer 3569 | IL6 | infer 3690 | ITGB3 | infer 4049 | LTA | infer 4524 | MTHFR | infer 7124 | TNF | infer 7132 | TNFRSF1A | infer 7133 | TNFRSF1B | infer 7157 | TP53 | infer 7172 | TPMT | infer |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1028 |
|---|---|
| Disease | lymphoproliferative disorders |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:7) C0009450 | infection | 15 C0042769 | virus infection | 5 C0024299 | lymphomas | 3 C0017658 | glomerulonephritis | 1 C0002880 | autoimmune hemolytic anemia | 1 C0002878 | hemolytic anemia | 1 C1136085 | monoclonal gammopathy | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:12) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs113488022 | 23161722 | 673 | BRAF | umls:C0024314 | BeFree | Investigation of the BRAF V600E mutation by pyrosequencing in lymphoproliferative disorders. | 0.000542884 | 2012 | BRAF | 7 | 140753336 | A | T,G,C |
| rs386626619 | 19816006 | 3717 | JAK2 | umls:C0024314 | BeFree | Absence of the V617F JAK2 mutation in the lymphoid compartment in a patient with essential thrombocythemia and B-chronic lymphocytic leukemia and in two relatives with lymphoproliferative disorders. | 0.003181358 | 2009 | NA | NA | NA | NA | NA |
| rs386626619 | 18032883 | 3717 | JAK2 | umls:C0024314 | BeFree | The JAK2(V617F) mutation, which has been found in patients with myeloproliferative disorders (MPD), has not yet been evaluated in lymphoproliferative disorders by any adequately sensitive techniques. | 0.003181358 | 2007 | NA | NA | NA | NA | NA |
| rs387907272 | 24573383 | 4615 | MYD88 | umls:C0024314 | BeFree | This has fueled major interest in the field and as newer evidence accumulates, it is clear that that discovery of MYD88 L265P mutation may represent an important breakthrough in understanding the pathogenesis of WM and lymphoproliferative disorders. | 0.001628651 | 2014 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 24143001 | 28395 | IGHV4-34 | umls:C0024314 | BeFree | The absence of plasmacytoid cells, the presence of plasma cells predominantly outside the nodular lymphoid infiltrates, IGHV4-34 restriction and absence of MYD88 L265P mutation strongly suggest that cold agglutinin-associated lymphoproliferative disease is a distinct entity that is different from lymphoplasmacytic lymphoma. | 0.000542884 | 2015 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 24842316 | 4615 | MYD88 | umls:C0024314 | BeFree | An oncogenic gain-of-function mutation (L265P) in the human MYD88 gene has been found to be present in most cases of WM/LPL, yet is absent in most other cases of B-cell chronic lymphoproliferative disorders (LPD), including SMZL. | 0.001628651 | 2014 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 24143001 | 4615 | MYD88 | umls:C0024314 | BeFree | The absence of plasmacytoid cells, the presence of plasma cells predominantly outside the nodular lymphoid infiltrates, IGHV4-34 restriction and absence of MYD88 L265P mutation strongly suggest that cold agglutinin-associated lymphoproliferative disease is a distinct entity that is different from lymphoplasmacytic lymphoma. | 0.001628651 | 2015 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 24992174 | 4615 | MYD88 | umls:C0024314 | BeFree | To sum up, ASO-RQ-PCR is an inexpensive, robust, and optimized method for the detection of MYD88 L265P mutation, which could be considered as a useful molecular tool during the diagnostic work-up of B-cell lymphoproliferative disorders. | 0.001628651 | 2015 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 23955458 | 4615 | MYD88 | umls:C0024314 | BeFree | MYD88 L265P somatic mutation: its usefulness in the differential diagnosis of bone marrow involvement by B-cell lymphoproliferative disorders. | 0.001628651 | 2013 | MYD88 | 3 | 38141150 | T | C |
| rs387907272 | 23446312 | 4615 | MYD88 | umls:C0024314 | BeFree | We evaluated the MYD88 L265P mutation in Waldenström's macroglobulinemia (WM) and B-cell lymphoproliferative disorders by specific polymerase chain reaction (PCR) (sensitivity ∼10(-3)). | 0.001628651 | 2013 | MYD88 | 3 | 38141150 | T | C |
| rs77375493 | 18032883 | 3717 | JAK2 | umls:C0024314 | BeFree | The JAK2(V617F) mutation, which has been found in patients with myeloproliferative disorders (MPD), has not yet been evaluated in lymphoproliferative disorders by any adequately sensitive techniques. | 0.003181358 | 2007 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs77375493 | 19816006 | 3717 | JAK2 | umls:C0024314 | BeFree | Absence of the V617F JAK2 mutation in the lymphoid compartment in a patient with essential thrombocythemia and B-chronic lymphocytic leukemia and in two relatives with lymphoproliferative disorders. | 0.003181358 | 2009 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0024314 | epirubicin | D015251 | 56420-45-2 | lymphoproliferative disorders | MESH:D008232 | therapeutic | 2624510 | ||
| C0024314 | lindane | D001556 | 58-89-9 | lymphoproliferative disorders | MESH:D008232 | marker/mechanism | 86552 | ||
| C0024314 | methotrexate | D008727 | 1959/5/2 | lymphoproliferative disorders | MESH:D008232 | marker/mechanism | 19001256 | ||
| C0024314 | methotrexate | D008727 | 1959/5/2 | lymphoproliferative disorders | MESH:D008232 | therapeutic | 9164227 | ||
| C0024314 | mitoxantrone | D008942 | 65271-80-9 | lymphoproliferative disorders | MESH:D008232 | therapeutic | 2624510 | ||
| C0024314 | tacrolimus | D016559 | 109581-93-3 | lymphoproliferative disorders | MESH:D008232 | marker/mechanism | 10743694 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |